carbamazepine has been researched along with Brain Injuries in 35 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years." | 9.14 | [Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010) |
| "Five patients with a moderate to severe degree of nonhereditary chorea were successfully treated with standard anticonvulsant doses of carbamazepine." | 7.67 | Carbamazepine: an alternative drug for the treatment of nonhereditary chorea. ( Gallart, A; Montserrat, L; Roig, M, 1988) |
| "Carbamazepine dosage was adjusted individually to provide serum levels within therapeutic range." | 6.65 | [Seizure prevention using carbamazepine following severe brain injuries]. ( Glötzner, FL; Haubitz, I; Kapp, G; Miltner, F; Pflughaupt, KW, 1983) |
| "DRESS syndrome is an idiosyncratic reaction to drugs, which can occur in both adults and children." | 5.39 | Carbamazepine-induced DRESS syndrome in a child: rapid response to pulsed corticosteroids. ( Tan, B; Teng, P, 2013) |
| "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years." | 5.14 | [Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010) |
| " Two years later she developed epilepsy secondary to brain trauma and as a result, she started receiving oxcarbamazepine treatment." | 3.77 | [The effect of oxcarbamazepine on the clinical effectiveness of dopamine agonists in the treatment of prolactinoma]. ( Kedzia, A; Krysiak, R; Okopień, B, 2011) |
| "Five patients with a moderate to severe degree of nonhereditary chorea were successfully treated with standard anticonvulsant doses of carbamazepine." | 3.67 | Carbamazepine: an alternative drug for the treatment of nonhereditary chorea. ( Gallart, A; Montserrat, L; Roig, M, 1988) |
| "Carbamazepine dosage was adjusted individually to provide serum levels within therapeutic range." | 2.65 | [Seizure prevention using carbamazepine following severe brain injuries]. ( Glötzner, FL; Haubitz, I; Kapp, G; Miltner, F; Pflughaupt, KW, 1983) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| "Antiepileptic prophylaxis reduces early seizures, but their use beyond 1 week does not prevent the development of post-traumatic epilepsy." | 1.43 | Antiepileptic prophylaxis following severe traumatic brain injury within a military cohort. ( Craner, M; Cranley, MR; McGilloway, E, 2016) |
| "The incidences of convulsion, coma, and respiratory failure were 14 (35%), 10 (25%), and 3 (7." | 1.43 | Severe Carbamazepine Intoxication in Children: Analysis of a 40-Case Series. ( Acikgoz, M; Alacam, A; Alacam, F; Guzel, A; Paksu, MS, 2016) |
| "Early treatment of epilepsy is warranted to avoid possible severe consequences." | 1.39 | Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013) |
| "DRESS syndrome is an idiosyncratic reaction to drugs, which can occur in both adults and children." | 1.39 | Carbamazepine-induced DRESS syndrome in a child: rapid response to pulsed corticosteroids. ( Tan, B; Teng, P, 2013) |
| "Fourteen patients developed seizures during that period and 25 did not." | 1.37 | Risk factors for late-onset seizures related to cerebral contusions in adults with a moderate traumatic brain injury. ( De Reuck, J, 2011) |
| " Carbamazepine at a dosage of 800 mg daily was the most effective medication used." | 1.33 | Auditory hallucinations after right temporal gyri resection. ( Brennan, DM; Stewart, B, 2005) |
| "Carbamazepine was added to her treatment regimen with good results." | 1.27 | Bipolar illness following traumatic brain injury: treatment with lithium and carbamazepine. ( Hemsath, RH; Stewart, JT, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 10 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rapinesi, C | 1 |
| Del Casale, A | 1 |
| Serata, D | 1 |
| Kotzalidis, GD | 1 |
| Scatena, P | 1 |
| Muzi, A | 1 |
| Lazanio, S | 1 |
| Savoja, V | 1 |
| Carbonetti, P | 1 |
| Fensore, C | 1 |
| Ferracuti, S | 1 |
| Angeletti, G | 1 |
| Tatarelli, R | 1 |
| Girardi, P | 1 |
| Teng, P | 1 |
| Tan, B | 1 |
| Cranley, MR | 1 |
| Craner, M | 1 |
| McGilloway, E | 1 |
| Acikgoz, M | 1 |
| Paksu, MS | 1 |
| Guzel, A | 1 |
| Alacam, A | 1 |
| Alacam, F | 1 |
| Prashantha, DK | 1 |
| Pal, PK | 1 |
| Bharath, RD | 1 |
| Waters, E | 1 |
| Morrall, MC | 1 |
| Murdoch-Eaton, D | 1 |
| De Reuck, J | 1 |
| Toledo, M | 1 |
| Munuera, J | 1 |
| Salas-Puig, X | 1 |
| Santamarina, E | 1 |
| Lacuey, N | 1 |
| Rovira, A | 1 |
| Krysiak, R | 1 |
| Kedzia, A | 1 |
| Okopień, B | 1 |
| Chang, BS | 1 |
| Lowenstein, DH | 1 |
| Richard, I | 1 |
| Perrouin-Verbe, B | 1 |
| Rome, J | 1 |
| Bernat, C | 1 |
| Mathé, JF | 1 |
| Beresford, TP | 1 |
| Arciniegas, D | 1 |
| Clapp, L | 1 |
| Martin, B | 1 |
| Alfers, J | 1 |
| Stewart, B | 1 |
| Brennan, DM | 1 |
| Glötzner, FL | 1 |
| Haubitz, I | 1 |
| Miltner, F | 1 |
| Kapp, G | 1 |
| Pflughaupt, KW | 1 |
| Baratz, R | 1 |
| Mesulam, MM | 1 |
| Karbowski, K | 2 |
| Smith, KR | 1 |
| Goulding, PM | 1 |
| Wilderman, D | 1 |
| Goldfader, PR | 1 |
| Holterman-Hommes, P | 1 |
| Wei, F | 1 |
| Pourcher, E | 1 |
| Filteau, MJ | 1 |
| Bouchard, RH | 1 |
| Baruch, P | 1 |
| Chatham-Showalter, PE | 1 |
| Persinger, MA | 1 |
| Perino, C | 1 |
| Rago, R | 1 |
| Cicolini, A | 1 |
| Torta, R | 1 |
| Monaco, F | 1 |
| Tobias, JD | 1 |
| Johnson, JO | 1 |
| Temkin, NR | 1 |
| Shucart, WA | 1 |
| Jackson, I | 1 |
| Jacobi, G | 1 |
| Fodstad, H | 1 |
| Ljunggren, BC | 1 |
| Dupuis, RE | 1 |
| Miranda-Massari, J | 1 |
| Massagli, TL | 1 |
| Heikkinen, ER | 1 |
| Rönty, HS | 1 |
| Tolonen, U | 1 |
| Pyhtinen, J | 1 |
| Roig, M | 1 |
| Montserrat, L | 1 |
| Gallart, A | 1 |
| Stewart, JT | 1 |
| Hemsath, RH | 1 |
| Borromei, A | 1 |
| Caramelli, R | 1 |
| Cipriani, G | 1 |
| Giancola, LC | 1 |
| Guerra, L | 1 |
| Lozito, A | 1 |
| Mistler, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates?[NCT03054285] | Phase 4 | 2,300 participants (Anticipated) | Interventional | 2017-07-01 | Recruiting | ||
| Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression: A 42-Day, Single-Site, Forced-Titration, Parallel Group, Randomized, Double-Blind, Placebo Controlled Trial[NCT00621751] | 70 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Study physician's impression of change since study onset. Clinicians Global Impressions of Change (CGI) is a sensitive, standardized tool to assess psychopharmacologic treatment response completed by the study physician. The Global Improvement (GI) CGI subscale documented the clinician's impression of change. The GI uses a 7-point scale to assess beneficial and negative effects. Low GI values (1 -3) indicate improvement; higher values (4-7) represent worsening. (NCT00621751)
Timeframe: 42 days
| Intervention | units on a scale (Mean) |
|---|---|
| Carbamazepine | 3.1 |
| Placebo | 2.9 |
Global Impression of Change (GIC) is a 5-item Likert Scale rated participants and observer impression of change in the person with TBI. Responses range 1 = much improved to 5 = much worse. (NCT00621751)
Timeframe: 42 days
| Intervention | units on a scale (Mean) |
|---|---|
| Carbamazepine | 3.3 |
| Placebo | 3.1 |
Global Impression of Change (GIC) is a 5-item Likert Scale rated participants and observer impression of change in the person with TBI. Responses range 1 = much improved to 5 = much worse. (NCT00621751)
Timeframe: Day-42
| Intervention | score on a scale (Mean) |
|---|---|
| Carbamazepine | 3.1 |
| Placebo | 3.1 |
Neuropsychiatry Inventory-Irritability (NPI-I) & Aggression domains (NPI-A): NPI is a 40-item assessment of 12 behavioral domains (NPI-I & NPI-A domains used in this study). The most problematic aspect of each domain is graded for severity (1=mild, to 3=severe) and frequency (1-4 with 4 representing highest frequency); the domain scores (0-12) are the product of severity and frequency. To best reflect treatment target intent and meet parametric statistical method criteria, the primary outcome was a composite measure of observer-rated NPI-I & -A domains transformed to a Rasch logit scale running from 0 (best) to 100 (worse) units (i.e., observer-rated NPI-I/A Rasch construct scores). Mean day-42 observer-rated NPI-I/A Rasch construct scores were compared between placebo vs. carbamazepine using ANCOVA with baseline score as covariate. (NCT00621751)
Timeframe: 42 days
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Carbamazepine | 37.7 |
| Placebo | 36.7 |
Neuropsychiatry Inventory-Irritability (NPI-I) & Aggression domains (NPI-A): NPI is a 40-item assessment of 12 behavioral domains (NPI-I & NPI-A domains used in this study). The most problematic aspect of each domain is graded for severity (1=mild, to 3=severe) and frequency (1-4 with 4 representing highest frequency); the domain scores (0-12) are the product of severity and frequency. To best reflect treatment target intent and meet parametric statistical method criteria, a composite measure of participant-rated NPI-I & -A domains transformed to a Rasch logit scale running from 0 (best) to 100 (worse) units (i.e., participant-rated NPI-I/A Rasch construct scores). Mean day-42 participant-rated NPI-I/A Rasch construct scores were compared between placebo vs. CBZ using ANCOVA with baseline score as covariate. (NCT00621751)
Timeframe: Day 42
| Intervention | score on a scale (Least Squares Mean) |
|---|---|
| Carbamazepine | 37.5 |
| Placebo | 36.4 |
Proportion of participants with Minimal Clinically Important Difference (MCID) on Neuropsychiatric Inventory Irritability-Aggression Composite Measure completed by Observer. Specifically, the proportion of participants that experienced a decrease of > 1 (MCID) in the NPI-I/A Rasch construct score (i.e., participants that are considered to have meaningful reduction in irritability/aggression) from baseline to day-42 between the groups using a chi-square test. MCID was defined as 0.5 times the standard deviation of baseline scores. (NCT00621751)
Timeframe: 42-day
| Intervention | Participants (Count of Participants) |
|---|---|
| Carbamazepine | 20 |
| Placebo | 26 |
Proportion of participants with Minimal Clinically Important Difference (MCID) on Neuropsychiatric Inventory Irritability-Aggression Composite Measure completed by Participant. Specifically, the proportion of participants that experienced a decrease of > 1 (MCID) in the NPI-I/A Rasch construct score (i.e., participants that are considered to have meaningful reduction in irritability/aggression) from baseline to day-42 between the groups using a chi-square test. MCID was defined as 0.5 times the standard deviation of baseline scores. (NCT00621751)
Timeframe: Day-42
| Intervention | Participants (Count of Participants) |
|---|---|
| Carbamazepine | 21 |
| Placebo | 16 |
11 reviews available for carbamazepine and Brain Injuries
| Article | Year |
|---|---|
Archimedes. Question 3. Should carbamazepine be administered to manage agitation and aggressive behaviour following paediatric acquired brain injury?
Topics: Adolescent; Anticonvulsants; Brain Injuries; Carbamazepine; Child Behavior Disorders; Evidence-Based | 2010 |
Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology.
Topics: Acute Disease; Adult; Animals; Anticonvulsants; Brain Injuries; Carbamazepine; Child; Controlled Cli | 2003 |
[Pharmacological treatment of post-traumatic behavioural disorders].
Topics: Adrenergic beta-Antagonists; Aggression; Anti-Anxiety Agents; Antidepressive Agents; Antimanic Agent | 2003 |
[The post-traumatic epilepsy (author's transl)].
Topics: Brain Concussion; Brain Injuries; Brain Neoplasms; Carbamazepine; Diagnostic Errors; Electroencephal | 1981 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
[The psycho-motor epilepsy (author's transl)].
Topics: Adolescent; Adult; Brain Injuries; Carbamazepine; Child; Diagnosis, Differential; Diseases in Twins; | 1978 |
Management of diabetes insipidus in neurosurgical patients.
Topics: Administration, Intranasal; Benzothiadiazines; Brain Injuries; Carbamazepine; Chlorpropamide; Deamin | 1976 |
[Post-traumatic epilepsy].
Topics: Brain Injuries; Carbamazepine; Child; Dose-Response Relationship, Drug; Electroencephalography; Epil | 1992 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
Neurobehavioral effects of phenytoin, carbamazepine, and valproic acid: implications for use in traumatic brain injury.
Topics: Barbiturates; Brain Injuries; Carbamazepine; Cognition; Contraindications; Humans; Phenytoin; Valpro | 1991 |
[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Child; Child, Preschool; Drug The | 1987 |
3 trials available for carbamazepine and Brain Injuries
| Article | Year |
|---|---|
[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children].
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Child; Epilepsies, Part | 2010 |
[Seizure prevention using carbamazepine following severe brain injuries].
Topics: Brain Concussion; Brain Injuries; Carbamazepine; Epilepsy, Post-Traumatic; Hematoma, Epidural, Crani | 1983 |
Neurobehavioral effects of phenytoin and carbamazepine in patients recovering from brain trauma: a comparative study.
Topics: Adult; Attention; Brain Injuries; Carbamazepine; Cognition; Double-Blind Method; Emotions; Female; H | 1994 |
21 other studies available for carbamazepine and Brain Injuries
| Article | Year |
|---|---|
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries | 2013 |
Carbamazepine-induced DRESS syndrome in a child: rapid response to pulsed corticosteroids.
Topics: Adolescent; Anti-Inflammatory Agents; Anticonvulsants; Brain Injuries; Carbamazepine; Drug Hypersens | 2013 |
Antiepileptic prophylaxis following severe traumatic brain injury within a military cohort.
Topics: Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Case-Control Studies; Chemoprevention; Cohort | 2016 |
Severe Carbamazepine Intoxication in Children: Analysis of a 40-Case Series.
Topics: Adolescent; Brain Injuries; Carbamazepine; Child; Child, Preschool; Coma; Female; Glasgow Coma Scale | 2016 |
Hyperventilation-induced painful tonic spasms secondary to a structural lesion of the pons.
Topics: Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Humans; Hyperventilation; Magnetic Resonance | 2010 |
Risk factors for late-onset seizures related to cerebral contusions in adults with a moderate traumatic brain injury.
Topics: Adult; Aged; Aging; Anticonvulsants; Brain; Brain Injuries; Carbamazepine; Electroencephalography; F | 2011 |
Localisation value of ictal arterial spin-labelled sequences in partial seizures.
Topics: Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Depressive Disorder; Diffusion Magnetic Reson | 2011 |
[The effect of oxcarbamazepine on the clinical effectiveness of dopamine agonists in the treatment of prolactinoma].
Topics: Adult; Brain Injuries; Bromocriptine; Carbamazepine; Dopamine Agonists; Drug Interactions; Drug Ther | 2011 |
Reduction of affective lability and alcohol use following traumatic brain injury: a clinical pilot study of anti-convulsant medications.
Topics: Adult; Alcoholism; Anticonvulsants; Anxiety Disorders; Brain Injuries; Carbamazepine; Female; Humans | 2005 |
Auditory hallucinations after right temporal gyri resection.
Topics: Adult; Affect; Anticonvulsants; Antipsychotic Agents; Brain Injuries; Carbamazepine; Electroencephal | 2005 |
Adult-onset stuttering treated with anticonvulsants.
Topics: Adult; Brain Injuries; Carbamazepine; Drug Therapy, Combination; Epilepsy, Post-Traumatic; Female; H | 1981 |
Efficacy of the combination of buspirone and carbamazepine in early posttraumatic delirium.
Topics: Adult; Brain Injuries; Buspirone; Carbamazepine; Delirium; Drug Therapy, Combination; Female; Head I | 1994 |
Carbamazepine for combativeness in acute traumatic brain injury.
Topics: Accidents, Traffic; Adult; Aggression; Brain Injuries; Carbamazepine; Critical Care; Female; Humans; | 1996 |
Subjective improvement following treatment with carbamazepine (Tegretol) for a subpopulation of patients with traumatic brain injuries.
Topics: Accidents, Traffic; Brain Injuries; Carbamazepine; Dichotic Listening Tests; Epilepsy; Factor Analys | 2000 |
Mood and behavioural disorders following traumatic brain injury: clinical evaluation and pharmacological management.
Topics: Adult; Antidepressive Agents; Brain Injuries; Brief Psychiatric Rating Scale; Carbamazepine; Citalop | 2001 |
Rapacuronium administration to patients receiving phenytoin or carbamazepine.
Topics: Adult; Anticonvulsants; Brain Injuries; Brain Neoplasms; Carbamazepine; Craniotomy; Drug Interaction | 2001 |
Baclofen and carbamazepine in supraspinal spasticity.
Topics: Administration, Oral; Adult; Baclofen; Brain Injuries; Carbamazepine; Drug Therapy, Combination; Fem | 1991 |
Development of posttraumatic epilepsy.
Topics: Adolescent; Adult; Aged; Alcoholism; Atrophy; Brain Injuries; Carbamazepine; Cerebral Cortex; Cerebr | 1990 |
Carbamazepine: an alternative drug for the treatment of nonhereditary chorea.
Topics: Brain Injuries; Carbamazepine; Child; Child, Preschool; Chorea; Drug Eruptions; Female; Humans; Male | 1988 |
Bipolar illness following traumatic brain injury: treatment with lithium and carbamazepine.
Topics: Adult; Bipolar Disorder; Brain Injuries; Carbamazepine; Female; Humans; Lithium; Lithium Carbonate; | 1988 |
[Preventive anticonvulsive treatment in recent brain injuries and brain diseases].
Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Electroencephalog | 1972 |