Page last updated: 2024-10-24

carbamazepine and Anxiety

carbamazepine has been researched along with Anxiety in 32 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"This study prospectively examined whether continued add-on treatment with oxcarbazepine (OXC) is associated with quantitative improvement in mood and anxiety symptoms in adult patients with partial epilepsy."9.12Oxcarbazepine improves mood in patients with epilepsy. ( Bria, P; Della Marca, G; Di Nicola, M; Janiri, L; Martinotti, G; Mazza, M; Mazza, S; Pozzi, G, 2007)
"Carbamazepine (CBZ) is one of the widely distributed pharmaceutical residues in aquatic environments, yet few researches have addressed its chronic effect on the anxiety of fish, and the mechanisms possibly involved remained elusive."8.31Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis. ( Chen, QL; Li, YW; Liu, ZH; Shen, YJ; Tan, ML; Xie, CT, 2023)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."7.78Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"This study prospectively examined whether continued add-on treatment with oxcarbazepine (OXC) is associated with quantitative improvement in mood and anxiety symptoms in adult patients with partial epilepsy."5.12Oxcarbazepine improves mood in patients with epilepsy. ( Bria, P; Della Marca, G; Di Nicola, M; Janiri, L; Martinotti, G; Mazza, M; Mazza, S; Pozzi, G, 2007)
"Carbamazepine (CBZ) is one of the widely distributed pharmaceutical residues in aquatic environments, yet few researches have addressed its chronic effect on the anxiety of fish, and the mechanisms possibly involved remained elusive."4.31Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis. ( Chen, QL; Li, YW; Liu, ZH; Shen, YJ; Tan, ML; Xie, CT, 2023)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."3.78Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"The successful use of antiepileptic drugs to treat a wide range of nonepileptic disorders led us to evaluate the potential efficacy of carbamazepine (CBZ) in anxiety disorders."3.75Role of ventral hippocampal GABA(A) and NMDA receptors in the anxiolytic effect of carbamazepine in rats using the elevated plus maze test. ( Bina, P; Rezvanfard, M; Zarrindast, MR, 2009)
"Medications targeting insomnia yielded mixed results."2.58Review: Adjunctive pharmacologic approaches for benzodiazepine tapers. ( Bogunovic, O; McHugh, RK; Tretyak, V; Weiss, RD; Welsh, JW, 2018)
"Levetiracetam was independently associated with anger/aggression, nervousness/agitation, upset stomach, depression, and sleep disturbance; lamotrigine with nervousness/agitation, upset stomach, and difficulty concentrating; and valproic acid with upset stomach and shaky hands."1.43Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study. ( Fidzinski, P; Gaus, V; Holtkamp, M; Kowski, AB; Losch, F; Weissinger, F, 2016)
" LGI1 gene dosage was performed by real-time quantitative PCR (qPCR)."1.38LGI1 microdeletion in autosomal dominant lateral temporal epilepsy. ( Barozzi, C; Cubeddu, T; de Falco, A; de Falco, FA; Errichiello, L; Fanciulli, M; Michelucci, R; Nobile, C; Rampazzo, A; Rigon, L; Santulli, L; Striano, P; Striano, S; Tomasi, L; Uzzau, S, 2012)
"To explore the time course of treatment-emergent adverse events (AEs) during topiramate (TPM) adjunctive therapy."1.33Time course of adverse events in patients with localization-related epilepsy receiving topiramate added to carbamazepine. ( Majkowski, J; Neto, W; Van Oene, J; Wapenaar, R, 2005)
") was antagonized by the chronic administration of lorazepam as well as sodium valproate, a GABA agonist."1.28The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate. ( de Angelis, L, 1992)
"Treatment with carbamazepine attenuated (P less than 0."1.28Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine. ( Browne, TR; Galpern, WR; Greenblatt, DJ; Miller, LG; Shader, RI; Szabo, GK, 1991)
"Fundamental withdrawal symptoms (like hypersensitivity to sensory stimuli, abnormal perception of movement, depersonalisation or derealisation) were also less severe in the group treated with CBZ compared with the group not receiving that treatment."1.28Treatment of benzodiazepine withdrawal symptoms with carbamazepine. ( Apelt, S; Bronisch, T; Emrich, HM; Garcia-Borreguero, D; Yassouridis, A, 1991)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19905 (15.63)18.7374
1990's8 (25.00)18.2507
2000's7 (21.88)29.6817
2010's9 (28.13)24.3611
2020's3 (9.38)2.80

Authors

AuthorsStudies
Xie, CT1
Tan, ML1
Li, YW1
Chen, QL1
Shen, YJ1
Liu, ZH1
Schmitz, B1
Dimova, S1
Zhang, Y1
Chellun, D1
De Backer, M1
Gasalla, T1
Hamed, SA1
Attiah, FA1
Gabra, RH1
Sherif, TK1
Häfele, CA1
Freitas, MP1
Gervini, BL1
de Carvalho, RM1
Rombaldi, AJ1
Welsh, JW1
Tretyak, V1
McHugh, RK1
Weiss, RD1
Bogunovic, O1
Silva, EF1
Silva, AI1
Asth, L1
Souza, LS1
Zaveri, NT1
Guerrini, R1
Calo', G1
Ruzza, C1
Gavioli, EC1
Barker-Haliski, ML1
Dahle, EJ1
Heck, TD1
Pruess, TH1
Vanegas, F1
Wilcox, KS1
White, HS1
Kowski, AB1
Weissinger, F1
Gaus, V1
Fidzinski, P1
Losch, F1
Holtkamp, M1
Rezvanfard, M1
Zarrindast, MR1
Bina, P1
Balogh, A1
Szentesi, A1
Jánosi, I1
Vadász, D1
Klivényi, P1
Vécsei, L1
Fanciulli, M1
Santulli, L1
Errichiello, L1
Barozzi, C1
Tomasi, L1
Rigon, L1
Cubeddu, T1
de Falco, A1
Rampazzo, A1
Michelucci, R1
Uzzau, S1
Striano, S1
de Falco, FA1
Striano, P1
Nobile, C1
Maschio, M1
Dinapoli, L1
Sperati, F1
Pace, A1
Fabi, A1
Vidiri, A1
Pompili, A1
Carapella, CM1
Kaufman, KR1
Gerner, R1
Majkowski, J1
Neto, W1
Wapenaar, R1
Van Oene, J1
Tölle, T1
Dukes, E1
Sadosky, A1
Mazza, M1
Della Marca, G1
Di Nicola, M1
Martinotti, G1
Pozzi, G1
Janiri, L1
Bria, P1
Mazza, S1
Borromei, A1
Bertocchi, S1
Kranzler, HR2
Bauer, LO2
Hersh, D1
Klinghoffer, V1
Gillen, RW1
Burleson, JA1
Samarel, D1
Morrison, DJ1
Paetzold, W1
Eronat, V1
Seifert, J1
Holze, I1
Emrich, HM2
Schneider, U1
Malcolm, R1
Myrick, H1
Roberts, J1
Wang, W1
Anton, RF1
de Angelis, L1
Kopchia, KL1
Altman, HJ1
Commissaris, RL1
Galpern, WR1
Miller, LG1
Greenblatt, DJ1
Szabo, GK1
Browne, TR1
Shader, RI1
Garcia-Borreguero, D1
Bronisch, T1
Apelt, S1
Yassouridis, A1
Altshuler, LL1
Devinsky, O1
Post, RM1
Theodore, W1
Almeida, RN1
Leite, JR2
Zangrossi Júnior, H1
Graeff, FG1
Risse, SC1
Barnes, R1
Lehmann, HE1
Ban, TA1
Babington, RG1
Horovitz, ZP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Monitoring of Seizures, EEG and Serum Antiepileptic Drug Concentrations in Patients With Uncontrolled Epilepsy[NCT00001149]900 participants Observational1975-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for carbamazepine and Anxiety

ArticleYear
Review: Adjunctive pharmacologic approaches for benzodiazepine tapers.
    Drug and alcohol dependence, 2018, 08-01, Volume: 189

    Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Carbamazepine; Humans; Hypnotics and

2018
Pharmacologic treatment of agitation associated with dementia.
    Journal of the American Geriatrics Society, 1986, Volume: 34, Issue:5

    Topics: Affective Symptoms; Aged; Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antipsychotic Agents;

1986

Trials

6 trials available for carbamazepine and Anxiety

ArticleYear
Tolerability and efficacy of lacosamide and controlled-release carbamazepine monotherapy in patients with newly diagnosed epilepsy and concomitant psychiatric conditions: Post hoc analysis of a prospective, randomized, double-blind trial.
    Epilepsy research, 2020, Volume: 159

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Delayed-Action Preparations; Depression; Doubl

2020
Oxcarbazepine improves mood in patients with epilepsy.
    Epilepsy & behavior : E&B, 2007, Volume: 10, Issue:3

    Topics: Adult; Analysis of Variance; Anticonvulsants; Antidepressive Agents; Anxiety; Carbamazepine; Case-Co

2007
Carbamazepine treatment of cocaine dependence: a placebo-controlled trial.
    Drug and alcohol dependence, 1995, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Alcoholism; Anticonvulsants; Anxiety; Carbamazepine; Cocaine; Comorbidity; Depres

1995
[Detoxification of poly-substance abusers with buprenorphine. Effects on affect, anxiety, and withdrawal symptoms].
    Der Nervenarzt, 2000, Volume: 71, Issue:9

    Topics: Adult; Affect; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Anxiety Agents; Anxiety; Bupreno

2000
The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification.
    The American journal on addictions, 2002,Spring, Volume: 11, Issue:2

    Topics: Adult; Affect; Alcoholism; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Carbamazepine; Double-Blin

2002
Studies with new drugs in the treatment of convulsive disorders.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1968, Volume: 1, Issue:3

    Topics: Adult; Aggression; Anticonvulsants; Anxiety; Carbamazepine; Clinical Trials as Topic; Diazepam; Dibe

1968

Other Studies

24 other studies available for carbamazepine and Anxiety

ArticleYear
Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2023, Volume: 266

    Topics: Animals; Anxiety; Carbamazepine; Female; gamma-Aminobutyric Acid; Hydrocortisone; Serotonin; Water P

2023
Sexual functions in women with focal epilepsy: Relationship to demographic, clinical, hormonal and psychological variables.
    Clinical neurology and neurosurgery, 2020, Volume: 191

    Topics: Adult; Anticonvulsants; Anxiety; Carbamazepine; Depression; Egypt; Epilepsy, Frontal Lobe; Epilepsy,

2020
Who are the individuals diagnosed with epilepsy using the Public Health System in the city of Pelotas, southern Brazil?
    Epilepsy & behavior : E&B, 2018, Volume: 78

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Anxiety; Brazil; Carbamazepine; Child; Cross-Sectional Stu

2018
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.
    Behavioural brain research, 2019, 01-01, Volume: 356

    Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Bipolar Disorder; Carbamazepine; Cycloheptanes; De

2019
Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 353, Issue:2

    Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carbamazepine; Cardiovirus Infections; Comorbid

2015
Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study.
    Epilepsy & behavior : E&B, 2016, Volume: 54

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Depression; Drug-Related Side Effects and Adve

2016
Role of ventral hippocampal GABA(A) and NMDA receptors in the anxiolytic effect of carbamazepine in rats using the elevated plus maze test.
    Pharmacology, 2009, Volume: 84, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbamazepine; Disease Models, Animal; GABA Agonists; GABA An

2009
[Multicenter observational study of the effect of oxcarbazepine on the general well-being of adults with partial epilepsy].
    Ideggyogyaszati szemle, 2010, Nov-30, Volume: 63, Issue:11-12

    Topics: Adult; Affect; Aged; Anticonvulsants; Anxiety; Carbamazepine; Epilepsies, Partial; Female; Happiness

2010
[Paroxysmal kinesigenic dyskinesia].
    Ideggyogyaszati szemle, 2011, Jan-30, Volume: 64, Issue:1-2

    Topics: Anticonvulsants; Anxiety; Carbamazepine; Chorea; Humans; Male; Quality of Life; Social Isolation; Yo

2011
LGI1 microdeletion in autosomal dominant lateral temporal epilepsy.
    Neurology, 2012, Apr-24, Volume: 78, Issue:17

    Topics: Adolescent; Adult; Anticonvulsants; Anxiety; Carbamazepine; Depressive Disorder, Major; Electroencep

2012
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
    Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr

2012
Adjunctive oxcarbazepine in comorbid anxiety and affective disorder with hyponatremic seizure: case analysis and literature review.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:6

    Topics: Adult; Anticonvulsants; Anxiety; Carbamazepine; Comorbidity; Drug Therapy, Combination; Follow-Up St

2003
Time course of adverse events in patients with localization-related epilepsy receiving topiramate added to carbamazepine.
    Epilepsia, 2005, Volume: 46, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Double-Blind Method; Drug Therapy,

2005
Patient burden of trigeminal neuralgia: results from a cross-sectional survey of health state impairment and treatment patterns in six European countries.
    Pain practice : the official journal of World Institute of Pain, 2006, Volume: 6, Issue:3

    Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antidepressive Agents; Anxiety; Carbamazep

2006
[Rational medical and surgical therapy of essential facial hemispasm. Experiences in 21 cases].
    Minerva medica, 1984, Oct-27, Volume: 75, Issue:41

    Topics: Adult; Aged; Angiography; Anxiety; Carbamazepine; Electroencephalography; Electromyography; Facial N

1984
Neuropsychologic findings in cocaine-dependent outpatients.
    Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:7

    Topics: Adult; Analgesics, Non-Narcotic; Anxiety; Carbamazepine; Cocaine-Related Disorders; Cognition; Human

1998
The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate.
    Methods and findings in experimental and clinical pharmacology, 1992, Volume: 14, Issue:10

    Topics: Animals; Anxiety; Behavior, Animal; Carbamazepine; Female; Lorazepam; Mice; Pentylenetetrazole; Valp

1992
Effects of lesions of the central nucleus of the amygdala on anxiety-like behaviors in the rat.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2

    Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbamazepine; Chlordiazepoxide; Conditioning, Operant

1992
Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine.
    Biochemical pharmacology, 1991, Dec-11, Volume: 42 Suppl

    Topics: Alprazolam; Animals; Anxiety; Carbamazepine; Cerebral Cortex; Disease Models, Animal; Drug Administr

1991
Treatment of benzodiazepine withdrawal symptoms with carbamazepine.
    European archives of psychiatry and clinical neuroscience, 1991, Volume: 241, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Carbamazepine; Crisis Intervention; Depression; Diazep

1991
Depression, anxiety, and temporal lobe epilepsy. Laterality of focus and symptoms.
    Archives of neurology, 1990, Volume: 47, Issue:3

    Topics: Adult; Analysis of Variance; Anxiety; Carbamazepine; Depression; Epilepsy, Temporal Lobe; Female; Fu

1990
Effects of acute or chronic carbamazepine on experimentally-induced conflict in the rat.
    Psychopharmacology, 1990, Volume: 100, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Carbamazepine; Conditioning, Operant; Conflict, Psychological; D

1990
Anxiolytic effect of carbamazepine measured in the elevated plus-maze.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1989, Volume: 22, Issue:6

    Topics: Animal Testing Alternatives; Animals; Anxiety; Carbamazepine; Exploratory Behavior; Male; Rats; Rats

1989
Neuropharmacology of SQ 10,996, a compound with several therapeutic indications.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 202, Issue:1

    Topics: Amides; Animals; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Carbamazepine; C

1973