carbamazepine and Anterior Choroidal Artery Infarction studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Research Excerpts

Excerpt	Relevance	Reference
"To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy."	9.11	New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
"INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH)."	7.69	A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. ( Tigaran, S, 1994)
"To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy."	5.11	New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. ( Boardman, KD; Carter, GS; Collins, JF; Felicetta, J; Frederick, T; Marks, W; Pryor, F; Ramsay, RE; Rowan, AJ; Spitz, M; Tomyanovich, ML; Towne, A; Uthman, BM, 2005)
"INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH)."	3.69	A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. ( Tigaran, S, 1994)
"A 62-year-old woman, who frequently had numbness seizures in the right half of her body, is reported."	2.67	Pure sensory seizures. ( Fukunishi, I; Hosokawa, K; Kohira, I; Kugoh, T; Okudaira, A; Yamamoto, M, 1993)
"Treatment with carbamazepine was successful in only one patient; in the other two subjects, their hiccups were controlled with haloperidol or baclofen."	1.30	Intractable hiccups during stroke rehabilitation. ( Dromerick, AW; Kumar, A, 1998)
"Four patients with viral encephalitis, carbamazepine intoxication, head trauma, and left-side, space-occupying hemispheric infarction, respectively."	1.30	Favorable recovery from bilateral loss of somatosensory evoked potentials. ( Aschoff, A; Hacke, W; Schwab, S; Schwarz, S, 1999)
"Pretreatment with phenytoin and carbamazepine prevented a reduction of this activity, which, without either treatment, was observed in the cerebral hemisphere exposed to 30-minute ischemia resulting from unilateral middle cerebral artery occlusion."	1.29	Effects of the conventional anticonvulsants, phenytoin, carbamazepine, and valproic acid, on sodium-potassium-adenosine triphosphatase in acute ischemic brain. ( Furui, T; Murakami, A, 1994)

Research

Studies (19)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

58-week Retention Rate Measured by the Number of Drop Outs Due to Adverse Events or Seizures From Day 1 of Treatment

Percentage of Patients Remaining Seizure Free at Week 58 (Visit 6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (5.26)	18.7374
1990's	11 (57.89)	18.2507
2000's	5 (26.32)	29.6817
2010's	2 (10.53)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Kim, JB	1
Yu, S	1
Pae, CU	1
Katsuno, M	1
Teramoto, A	1
Sasaki, M	1
Rowan, AJ	1
Ramsay, RE	1
Collins, JF	1
Pryor, F	1
Boardman, KD	1
Uthman, BM	1
Spitz, M	1
Frederick, T	1
Towne, A	1
Carter, GS	1
Marks, W	1
Felicetta, J	1
Tomyanovich, ML	1
Nagata, T	1
Harada, D	1
Aoki, K	1
Kada, H	1
Miyata, H	1
Kasahara, H	1
Nakayama, K	1
Tigaran, S	1
Bahro, M	1
Katzmann, KJ	1
Gückel, F	1
Sungurtekin, I	1
Riemann, D	1
Murakami, A	1
Furui, T	1
Yamamoto, M	1
Okudaira, A	1
Kohira, I	1
Kugoh, T	1
Fukunishi, I	1
Hosokawa, K	1
Dantendorfer, K	1
Amering, M	1
Prayer, D	1
Maierhofer, D	1
Schnider, P	1
Katschnig, H	1
Böttcher, T	1
Buchmann, J	1
Zettl, UK	1
Benecke, R	1
Minato, H	1
Kikuta, C	1
Fujitani, B	1
Masuda, Y	1
Kumar, A	1
Dromerick, AW	1
Schwarz, S	1
Schwab, S	1
Aschoff, A	1
Hacke, W	1
Rösel, T	1
Schneider, J	1
Fischer, JT	1
Druschky, KF	1
Terrence, C	1
Costa, R	1
Fromm, G	1
Anttila, VJ	1
Valtonen, M	1
Signer, SF	1
Krelina, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Multicentre, Double-blind, Randomized, Phase IV Clinical Trial Comparing the Safety, Tolerability and Efficacy of Levetiracetam Versus Lamotrigine and Carbamazepine in the Oral Antiepileptic Therapy of Newly Diagnosed Elderly Patients With Focal Epileps[NCT00438451]	Phase 4	361 participants (Actual)	Interventional	2007-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	proportion of participants (Mean)
Levetiracetam	0.61
Carbamazepine	0.46
Lamotrigine	0.56

Percentage of patients experiencing no seizures until week 58 (Visit 6) and did not discontinue the study until week 58. (NCT00438451)
Timeframe: week 58

Percentage of Patients Remaining Seizure-free at Week 30 (Visit 4)

Intervention	percentage of participants (Number)
Levetiracetam	43
Carbamazepine	33
Lamotrigine	38

Percentage of patients experiencing no seizures until week 30 (Visit 4) and did not discontinue the study until week 30. (NCT00438451)
Timeframe: Week 30

Proportion of Seizure-free Days During the Maintenance Phase for Subjects Who Enter the Maintenance Phase

Results of Cognitive Testing (EpiTrack© by UCB) - Score at V6

Intervention	percentage of participants (Number)
Levetiracetam	48
Carbamazepine	39
Lamotrigine	49

Intervention	proportion of seizure-free days (Number)
Levetiracetam	0.99
Carbamazepine	0.99
Lamotrigine	0.99

EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. The results of EPITrack Score ranges between 7 and 45. (NCT00438451)
Timeframe: week 58

The Absolute Seizure Frequency During the Maintenance Phase (Weeks 7 - 58)

Intervention	units on a scale (Mean)
Levetiracetam	26.0
Carbamazepine	26.0
Lamotrigine	25.4

"Seizure frequency was assessed by investigators in the CRF at the Visits V3, V4, V5 and V6.~The absolute seizure frequency during the maintenance phase was defined as the sum of those entries." (NCT00438451)
Timeframe: over 52 weeks

The Time (in Days) to First Break-through Seizure (From Day 1 of Treatment)

Time to Drop Out

Intervention	number of seizures (Number)
Levetiracetam	168
Carbamazepine	131
Lamotrigine	130

Intervention	days (Median)
Levetiracetam	NA
Carbamazepine	NA
Lamotrigine	NA

number of days between randomization and premature discontinuation of the study (NCT00438451)
Timeframe: 58 weeks

Portland Neurotoxicity Scale (PNS) at V6

Intervention	days (Median)
Levetiracetam	NA
Carbamazepine	265
Lamotrigine	NA

"The PNS is a 15-item scale. Each item can be scored from 1 to 9. There are a total score (includes all items, range:15 to 135) and two subscores: The cognitive toxicity subscore (10 items: Energy Level, Memory, Interest, Concentration, Forgetfulness, Sleepliness, Moodiness, Alertness, Attention Span, Motivation, range:10 to 90) and the somatomoto subscore (5 items: Vision, Walking, Coordination, Tremor, Speech, range:5-45). The score is calculated by taking the mean of all non-missing values times the number of items.~Lower values indicate better quality of life." (NCT00438451)
Timeframe: at week 58

QOLIE-31 (Quality Of Life In Epilepsy) Results at V6

Intervention	units on a scale (Mean)
	Cognitive toxicity subscore	Somatomotor subscore	Total Score
Carbamazepine	27.3	11.4	38.7
Lamotrigine	23.7	10.8	34.5
Levetiracetam	22.2	10.5	32.7

The QOLIE-31 is a 31 item score that measures the quality of life in epilepsy (each item with a range of 0 to 100). There are 7 sub-scores seizure worry (items 11,21,22,23,25), overall quality of life (items 1,14), emotional well-being (items 3,4,5,7,9), energy/fatigue (items 2,6,8,10), cognitive functioning (items 12,15,16,17,18,26), medication effects (items 24,29,30) and social functioning (13,19,20,27,28). These scores were combined to a total score by Total score = seizure worry*0.08 + overall quality of life*0.14 + emotional well-being*0.15 + energy/fatigue*0.12 + cognitive functioning*0.27 + medication effects*0.03 + social functioning*0.21 For all scores, higher values indicate better quality of life. Each score has a possible range from 0 to 100. (NCT00438451)
Timeframe: 58 weeks, final visit

Intervention	units on a scale (Mean)
	Seizure worry	Overall quality of life	Emotional well-being	Energy/fatigue	Cognitive functioning	Medication effects	Social functioning	Total Score	Health Scale
Carbamazepine	75.4	65.0	69.8	54.5	68.9	70.6	76.3	68.9	65.7
Lamotrigine	75.0	67.1	67.4	59.8	68.0	72.6	76.7	69.1	67.5
Levetiracetam	85.1	67.2	72.0	60.8	75.1	77.6	81.1	73.9	69.5

"Evaluation of current testing at V6:~≥29 score points: Inconspicuous; 26 to 28 score points: Borderline;~≤25 score points: Impaired" (NCT00438451)
Timeframe: 58 weeks

Intervention	participants (Number)
	Without pathological findings	Borderline	Impaired
Carbamazepine	34	17	33
Lamotrigine	31	15	39
Levetiracetam	38	10	36

"Evaluation of Changes~Changes in the EpiTrack® Score were categorized as follows:~≥5 score points: Improved;~-3 to 4 score points: Unchanged;~≤-4 score points: Worsened" (NCT00438451)
Timeframe: week 58

Reviews

Trials

Other Studies

16 other studies available for carbamazepine and Anterior Choroidal Artery Infarction

Article	Year
New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology, 2005, Jun-14, Volume: 64, Issue:11 Topics: Aged; Aging; Amines; Anticonvulsants; Carbamazepine; Cerebral Infarction; Cyclohexanecarboxylic Acid	2005
Pure sensory seizures. Seizure, 1993, Volume: 2, Issue:1 Topics: Carbamazepine; Cerebral Infarction; Electroencephalography; Epilepsies, Partial; Female; Functional	1993

Article	Year
Neurological picture. Trigeminal neuralgia after pontine infarction affecting the ipsilateral trigeminal nerve. Journal of neurology, neurosurgery, and psychiatry, 2013, Volume: 84, Issue:8 Topics: Amines; Analgesics, Non-Narcotic; Carbamazepine; Cerebral Infarction; Cyclohexanecarboxylic Acids; G	2013
Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions. Psychiatry and clinical neurosciences, 2008, Volume: 62, Issue:4 Topics: Aggression; Anticonvulsants; Benzodiazepines; Carbamazepine; Cerebral Infarction; Disruptive, Impuls	2008
Secondary trigeminal neuropathy and neuralgia resulting from pontine infarction. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2010, Volume: 19, Issue:3 Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Carbamazepi	2010
Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions. Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:6 Topics: Aggression; Antimanic Agents; Benzodiazepines; Carbamazepine; Cerebral Infarction; Drug Resistance;	2007
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. Acta neurologica Scandinavica, 1994, Volume: 90, Issue:5 Topics: Adult; Carbamazepine; Cerebral Infarction; Dose-Response Relationship, Drug; Epilepsies, Partial; Fe	1994
[REM sleep parasomnia]. Der Nervenarzt, 1994, Volume: 65, Issue:8 Topics: Amitriptyline; Brain Stem; Carbamazepine; Cerebral Infarction; Dreams; Drug Therapy, Combination; Hu	1994
Effects of the conventional anticonvulsants, phenytoin, carbamazepine, and valproic acid, on sodium-potassium-adenosine triphosphatase in acute ischemic brain. Neurosurgery, 1994, Volume: 34, Issue:6 Topics: Animals; Carbamazepine; Cerebral Cortex; Cerebral Infarction; Dose-Response Relationship, Drug; Male	1994
Treatment of Koro and panic attacks after stroke. Anxiety, 1996, Volume: 2, Issue:1 Topics: Anticonvulsants; Carbamazepine; Cerebral Cortex; Cerebral Infarction; Clonazepam; Drug Therapy, Comb	1996
Carbamazepine-phenprocoumon interaction. European neurology, 1997, Volume: 38, Issue:2 Topics: Adult; Anticoagulants; Anticonvulsants; Carbamazepine; Cerebral Infarction; Cytochrome P-450 CYP3A;	1997
Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats. Epilepsia, 1997, Volume: 38, Issue:9 Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Body Temperature; Carbamazepine; Cerebral Art	1997
Intractable hiccups during stroke rehabilitation. Archives of physical medicine and rehabilitation, 1998, Volume: 79, Issue:6 Topics: Aged; Baclofen; Carbamazepine; Cerebral Infarction; Cerebrovascular Disorders; Chlorpromazine; Dopam	1998
Favorable recovery from bilateral loss of somatosensory evoked potentials. Critical care medicine, 1999, Volume: 27, Issue:1 Topics: Acute Disease; Adult; Carbamazepine; Cerebral Infarction; Craniocerebral Trauma; Encephalitis, Viral	1999
[Carbamazepine poisoning caused by confusing the drugs]. Deutsche medizinische Wochenschrift (1946), 2000, Mar-24, Volume: 125, Issue:12 Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cerebral Infarction; Diagnosis, Differential; Drug Over	2000
An unusual case of paroxysmal facial pain. Journal of neurology, 1979, Volume: 221, Issue:2 Topics: Brain Stem; Carbamazepine; Cerebral Infarction; Humans; Male; Middle Aged; Syndrome; Trigeminal Neur	1979
[Carbamazepine-induced diarrhea and eosinophilic inflammation of the colon]. Duodecim; laaketieteellinen aikakauskirja, 1990, Volume: 106, Issue:4 Topics: Carbamazepine; Cerebral Infarction; Colitis; Diarrhea; Eosinophilia; Humans; Male; Middle Aged; Seiz	1990
Hallucinations controlled with anticonvulsants. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:5 Topics: Carbamazepine; Cerebral Infarction; Depressive Disorder; Electroencephalography; Epilepsy, Temporal	1991

carbamazepine and Anterior Choroidal Artery Infarction