Page last updated: 2024-10-24

carbamazepine and Amentia

carbamazepine has been researched along with Amentia in 32 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Research Excerpts

ExcerptRelevanceReference
"The effects of long-term consequences of lithium, valproic acid, carbamazepine and antipsychotic agents on the development of dementia or cognitive impairments in patients with bipolar disorder were investigated."9.41[Effects of lithium, valproic acid, carbamazepine and antipsychotic agents on cognition in bipolar disorders-A systematic review]. ( Leopold, S; Quante, A, 2023)
"To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both."9.14Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. ( Aga, O; Cvancarova, M; Engedal, K; Olsen, IC; Selbaek, G; Sommer, OH, 2009)
"The aim of this study was to assess the effects of withdrawal from placebo and carbamazepine administered for agitation associated with dementia and to assess safety, tolerability, and efficacy of subsequent ongoing carbamazepine therapy."9.09Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, LJ; Lanning, B; Podgorski, CA; Tariot, PN, 1999)
"The efficacy, safety, and tolerability of carbamazepine in the treatment of agitation and aggression associated with dementia were assessed."9.08Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, L; Patel, S; Podgorski, CA; Tariot, PN, 1998)
"To determine the effects of carbamazepine versus placebo on ratings of behavior in agitated nursing home patients with dementia."9.07Carbamazepine treatment of agitation in nursing home patients with dementia: a preliminary study. ( Asnis, J; Cox, C; Erb, R; Irvine, C; Kolassa, J; Leibovici, A; Podgorski, CA; Tariot, PN, 1994)
" Controlled trials in elderly patients with epilepsy demonstrate efficacy and tolerability comparable to gabapentin."8.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"Carbamazepine was administered in an open pilot study to 13 patients with primary degenerative dementia characterized by aggressive and assaultive behavior refractory to conventional treatment."7.67A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. ( Patterson, JF, 1988)
"The effects of long-term consequences of lithium, valproic acid, carbamazepine and antipsychotic agents on the development of dementia or cognitive impairments in patients with bipolar disorder were investigated."5.41[Effects of lithium, valproic acid, carbamazepine and antipsychotic agents on cognition in bipolar disorders-A systematic review]. ( Leopold, S; Quante, A, 2023)
"Treatment with carbamazepine was evaluated in an open study design in 29 gerontopsychiatric inpatients."5.29[Therapeutic use of carbamazepine for treatment of agitation and affective disorders in geriatric psychiatry patients]. ( Lemke, MR; Stuhlmann, W, 1994)
"Dementia is an ailment that is becoming a major management problem."5.27Carbamazepine in dementia. ( Essa, M, 1986)
"To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both."5.14Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. ( Aga, O; Cvancarova, M; Engedal, K; Olsen, IC; Selbaek, G; Sommer, OH, 2009)
"The aim of this study was to assess the effects of withdrawal from placebo and carbamazepine administered for agitation associated with dementia and to assess safety, tolerability, and efficacy of subsequent ongoing carbamazepine therapy."5.09Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, LJ; Lanning, B; Podgorski, CA; Tariot, PN, 1999)
"The efficacy, safety, and tolerability of carbamazepine in the treatment of agitation and aggression associated with dementia were assessed."5.08Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, L; Patel, S; Podgorski, CA; Tariot, PN, 1998)
"To determine the effects of carbamazepine versus placebo on ratings of behavior in agitated nursing home patients with dementia."5.07Carbamazepine treatment of agitation in nursing home patients with dementia: a preliminary study. ( Asnis, J; Cox, C; Erb, R; Irvine, C; Kolassa, J; Leibovici, A; Podgorski, CA; Tariot, PN, 1994)
" The purpose of this review of the literature is to assess the interest and the limits of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate, oxcarbazepine) in the treatment of the so-called "noncognitive" symptoms of dementia."4.84[Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)]. ( Pinheiro, D, 2008)
" Controlled trials in elderly patients with epilepsy demonstrate efficacy and tolerability comparable to gabapentin."4.84Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia. ( Nanry, K; Ramsay, E; Sajatovic, M; Thompson, T, 2007)
"To review and summarize the currently available data on the use of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate) in the treatment of behavioral and psychological symptoms of dementia (BPSD); to determine whether these medications can be recommended for routine clinical use."4.84Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. ( Konovalov, S; Muralee, S; Tampi, RR, 2008)
" In epilepsy after trauma, levetiracetam had the highest retention rate at 80% (95% confidence interval [CI] = 65-89), exceeding that of the most commonly prescribed ASM, carbamazepine (p = ."4.02Potential for improved retention rate by personalized antiseizure medication selection: A register-based analysis. ( Garcia-Ptacek, S; Håkansson, S; Karlander, M; Larsson, D; Mahamud, Z; Zelano, J; Zelezniak, A, 2021)
"Carbamazepine was administered in an open pilot study to 13 patients with primary degenerative dementia characterized by aggressive and assaultive behavior refractory to conventional treatment."3.67A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. ( Patterson, JF, 1988)
"The phenytoin treatment causes cerebellar defect and anemia."2.82The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022)
" Although few studies are available, extrapolations from research in young people and elderly patients without dementia provide several recommendations for the management of seizures in patients with dementia: exclude symptomatic causes of seizures before committing to antiepileptic drug therapy; treat after a first seizure if there is evidence of focal neurological involvement or a risk of recurrent seizures; use antiepileptic drugs with minimal cognitive adverse effects, such as carbamazepine, valproic acid, gabapentin and lamotrigine; and use the lowest possible dosage and monitor antiepileptic drug levels, where possible."2.42Seizures in elderly patients with dementia: epidemiology and management. ( Lim, G; Mendez, M, 2003)
"Dementia affects 5% of persons over age 65 years and 20% of those over 80 years of age and is expected to increase further in the primary care setting as the population ages."2.39Management of the behavioral manifestations of dementia. ( Farnett, LE; Ruzicka, SA; Yeager, BF, 1995)
"The carbamazepine studies were inconclusive."2.38Nonneuroleptic treatment of disruptive behavior in organic mental syndromes. ( Perry, PJ; Smith, DA, 1992)
"We report on a 50-year-old man with mental retardation and right-sided hemi-paresis."1.32[Atypical epilepsy symptomatology as cause of a dementia like state in a mentally and physically retarded patient]. ( Huber, B; Seidel, M; Tomka-Hoffmeister, M, 2004)
"Treatment with carbamazepine was evaluated in an open study design in 29 gerontopsychiatric inpatients."1.29[Therapeutic use of carbamazepine for treatment of agitation and affective disorders in geriatric psychiatry patients]. ( Lemke, MR; Stuhlmann, W, 1994)
"Dementia is an ailment that is becoming a major management problem."1.27Carbamazepine in dementia. ( Essa, M, 1986)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19904 (12.50)18.7374
1990's12 (37.50)18.2507
2000's10 (31.25)29.6817
2010's3 (9.38)24.3611
2020's3 (9.38)2.80

Authors

AuthorsStudies
Panda, SP1
Dhurandhar, Y1
Agrawal, M1
Leopold, S1
Quante, A1
Håkansson, S1
Karlander, M1
Larsson, D1
Mahamud, Z1
Garcia-Ptacek, S1
Zelezniak, A1
Zelano, J1
Vilibić, M1
Jukić, V1
Vidović, A1
Brecić, P1
Meyer, JM1
Cummings, MA1
Proctor, G1
Stahl, SM1
Pinheiro, D1
Sommer, OH1
Aga, O1
Cvancarova, M1
Olsen, IC1
Selbaek, G1
Engedal, K1
Yeh, YC1
Ouyang, WC1
Gaber, TA1
Eshiett, M1
Mendez, M1
Lim, G1
Tomka-Hoffmeister, M1
Huber, B1
Seidel, M1
Freymann, N1
Michael, R1
Dodel, R1
Jessen, F1
Horvath, J1
Coeytaux, A1
Jallon, P1
Landis, T1
Temperli, P1
Burkhard, PR1
Sajatovic, M1
Ramsay, E1
Nanry, K1
Thompson, T1
Hollis, J1
Grayson, D1
Forrester, L1
Brodaty, H1
Touyz, S1
Cumming, R1
Konovalov, S1
Muralee, S1
Tampi, RR1
Tariot, PN4
Frederiksen, K1
Erb, R4
Leibovici, A2
Podgorski, CA4
Asnis, J2
Cox, C4
Yeager, BF1
Farnett, LE1
Ruzicka, SA1
Lemke, MR1
Stuhlmann, W1
Kolassa, J1
Irvine, C3
Mowadat, HR1
Kerr, EE1
StClair, D1
Mintzer, JE1
Brawman-Mintzer, O1
Gertz, HJ1
Göhringer, K1
Schimmelpfennig, C1
Patel, S1
Jakimovich, L1
Jakimovich, LJ1
Lanning, B1
Jokelainen, M1
Schneider, LS1
Sobin, PB1
Smith, DA1
Perry, PJ1
Risse, SC1
Barnes, R1
Essa, M1
Patterson, JF1
Nicholson, WJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Oxcarbazepine in the Treatment of Agitation / Aggression in Dementia (OBAD) - An Eight Week Prospective, Randomized, Double-Blind, Placebo-Controlled, Multi Center Trial. A Phase III Study[NCT00145691]Phase 3100 participants Interventional2005-09-30Completed
Levetiracetam for Alzheimer's Disease Neuropsychiatric Symptoms Related to Epilepsy Trial (LAPSE) - A Phase II Exploratory Study[NCT04004702]Phase 265 participants (Anticipated)Interventional2020-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for carbamazepine and Amentia

ArticleYear
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
    Mitochondrion, 2022, Volume: 66

    Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La

2022
[Effects of lithium, valproic acid, carbamazepine and antipsychotic agents on cognition in bipolar disorders-A systematic review].
    Der Nervenarzt, 2023, Volume: 94, Issue:5

    Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Cognition;

2023
Psychopharmacology of Persistent Violence and Aggression.
    The Psychiatric clinics of North America, 2016, Volume: 39, Issue:4

    Topics: Aggression; Antimanic Agents; Antipsychotic Agents; Brain Injuries, Traumatic; Carbamazepine; Clozap

2016
[Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)].
    L'Encephale, 2008, Volume: 34, Issue:4

    Topics: Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dementia; Fructose; Gabap

2008
Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: an update review.
    The Kaohsiung journal of medical sciences, 2012, Volume: 28, Issue:4

    Topics: Antipsychotic Agents; Carbamazepine; Dementia; Humans; Lamotrigine; Oxcarbazepine; Triazines; Valpro

2012
Seizures in elderly patients with dementia: epidemiology and management.
    Drugs & aging, 2003, Volume: 20, Issue:11

    Topics: Aged; Anticonvulsants; Carbamazepine; Case Management; Dementia; Epilepsy; Humans

2003
Lamotrigine therapy in elderly patients with epilepsy, bipolar disorder or dementia.
    International journal of geriatric psychiatry, 2007, Volume: 22, Issue:10

    Topics: Aged; Aged, 80 and over; Amines; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine;

2007
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
    International psychogeriatrics, 2008, Volume: 20, Issue:2

    Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids

2008
Management of the behavioral manifestations of dementia.
    Archives of internal medicine, 1995, Feb-13, Volume: 155, Issue:3

    Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antipsychotic Agents; Carbamazepine; Clinical Tria

1995
Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: toward a treatment approach.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 7

    Topics: Aged; Aggression; Antipsychotic Agents; Anxiety Disorders; Behavior Therapy; Buspirone; Carbamazepin

1996
Non-neuroleptic treatment of behavioral symptoms and agitation in Alzheimer's disease and other dementia.
    Psychopharmacology bulletin, 1992, Volume: 28, Issue:1

    Topics: Adrenergic beta-Antagonists; Alzheimer Disease; Buspirone; Carbamazepine; Dementia; Humans; Lithium;

1992
Nonneuroleptic treatment of disruptive behavior in organic mental syndromes.
    The Annals of pharmacotherapy, 1992, Volume: 26, Issue:11

    Topics: Adrenergic beta-Antagonists; Antisocial Personality Disorder; Autistic Disorder; Carbamazepine; Deme

1992
Pharmacologic treatment of agitation associated with dementia.
    Journal of the American Geriatrics Society, 1986, Volume: 34, Issue:5

    Topics: Affective Symptoms; Aged; Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antipsychotic Agents;

1986

Trials

5 trials available for carbamazepine and Amentia

ArticleYear
Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia.
    Dementia and geriatric cognitive disorders, 2009, Volume: 27, Issue:2

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Anticonvulsants; Carbamazepine; Dementia; De

2009
Lack of carbamazepine toxicity in frail nursing home patients: a controlled study.
    Journal of the American Geriatrics Society, 1995, Volume: 43, Issue:9

    Topics: Aged; Aged, 80 and over; Carbamazepine; Comorbidity; Cross-Over Studies; Dementia; Double-Blind Meth

1995
Carbamazepine treatment of agitation in nursing home patients with dementia: a preliminary study.
    Journal of the American Geriatrics Society, 1994, Volume: 42, Issue:11

    Topics: Aged; Aged, 80 and over; Carbamazepine; Cross-Over Studies; Dementia; Female; Homes for the Aged; Hu

1994
Efficacy and tolerability of carbamazepine for agitation and aggression in dementia.
    The American journal of psychiatry, 1998, Volume: 155, Issue:1

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Carbamazepine; Dementia; Dementia, Vascular;

1998
Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:10

    Topics: Aggression; Anticonvulsants; Brief Psychiatric Rating Scale; Carbamazepine; Dementia; Drug Administr

1999

Other Studies

14 other studies available for carbamazepine and Amentia

ArticleYear
Potential for improved retention rate by personalized antiseizure medication selection: A register-based analysis.
    Epilepsia, 2021, Volume: 62, Issue:9

    Topics: Anticonvulsants; Brain Injuries, Traumatic; Carbamazepine; Dementia; Epilepsy; Humans; Levetiracetam

2021
Cobalamin deficiency manifested with seizures, mood oscillations, psychotic features and reversible dementia in the absence of typical neurologic and hematologic signs and symptoms: a case report.
    Collegium antropologicum, 2013, Volume: 37, Issue:1

    Topics: Carbamazepine; Dementia; Diazepam; Electroencephalography; Haloperidol; Hematology; Humans; Hydroxoc

2013
Resolution of psychiatric symptoms secondary to herpes simplex encephalitis.
    Journal of neurology, neurosurgery, and psychiatry, 2003, Volume: 74, Issue:8

    Topics: Anticonvulsants; Carbamazepine; Dementia; Encephalitis, Herpes Simplex; Encephalomalacia; Female; Fo

2003
[Atypical epilepsy symptomatology as cause of a dementia like state in a mentally and physically retarded patient].
    Fortschritte der Neurologie-Psychiatrie, 2004, Volume: 72, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Dementia; Electroencephalography; Epilepsy; Humans; Intellectual Dis

2004
Successful treatment of sexual disinhibition in dementia with carbamazepine -- a case report.
    Pharmacopsychiatry, 2005, Volume: 38, Issue:3

    Topics: Aged; Anticonvulsants; Carbamazepine; Dementia; Humans; Male; Sexual Dysfunction, Physiological; Tre

2005
Carbamazepine encephalopathy masquerading as Creutzfeldt-Jakob disease.
    Neurology, 2005, Aug-23, Volume: 65, Issue:4

    Topics: Aged; Amines; Analgesics, Non-Narcotic; Atrophy; Basal Ganglia; Brain; Brain Damage, Chronic; Carbam

2005
Antipsychotic medication dispensing and risk of death in veterans and war widows 65 years and older.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2007, Volume: 15, Issue:11

    Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Australia; Benzodiazepi

2007
[Therapeutic use of carbamazepine for treatment of agitation and affective disorders in geriatric psychiatry patients].
    Psychiatrische Praxis, 1994, Volume: 21, Issue:4

    Topics: Aged; Carbamazepine; Dementia; Dose-Response Relationship, Drug; Drug Administration Schedule; Femal

1994
Sporadic Pick's disease in a 28-year-old woman.
    The British journal of psychiatry : the journal of mental science, 1993, Volume: 162

    Topics: Adult; Atrophy; Carbamazepine; Dementia; Electroconvulsive Therapy; Female; Frontal Lobe; Haloperido

1993
[Successful carbamazepine therapy of 2 cases of music hallucinations].
    Der Nervenarzt, 1996, Volume: 67, Issue:5

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Dementia; Female; Hallucinations; Humans; M

1996
[Dementia and carbamazepine medication in an elderly man].
    Duodecim; laaketieteellinen aikakauskirja, 1998, Volume: 114, Issue:6

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Humans; Hyponatremia; M

1998
Carbamazepine in dementia.
    Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:4

    Topics: Antipsychotic Agents; Carbamazepine; Dementia; Humans; Male; Middle Aged

1986
A preliminary study of carbamazepine in the treatment of assaultive patients with dementia.
    Journal of geriatric psychiatry and neurology, 1988, Volume: 1, Issue:1

    Topics: Aged; Aggression; Carbamazepine; Dementia; Dose-Response Relationship, Drug; Drug Administration Sch

1988
Medicine in old age. Disturbances of the special senses and other functions.
    British medical journal, 1974, Jan-05, Volume: 1, Issue:5896

    Topics: Aged; Carbamazepine; Deafness; Dementia; Epilepsy; Female; Geriatrics; Headache; Hematoma, Subdural;

1974