carbamazepine has been researched along with Alcohol Withdrawal Associated Autonomic Hyperactivity in 28 studies
Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Outcomes included incident seizures, delirium tremens, AW severity scores, adverse events, dropouts, dropouts from adverse events, length of hospital stay, use of additional medications, total benzodiazepine requirements, and death." | 2.82 | Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis. ( Bach, P; Bahji, A; Crockford, D; Danilewitz, M; Devoe, DJ; El-Guebaly, N; Saitz, R, 2022) |
| " No serious medical complications or adverse events were observed except for one case of delirium tremens." | 2.72 | Efficacy and safety of outpatient alcohol detoxification with a combination of tiapride/carbamazepine: additional evidence. ( Schmidt, F; Schmidt, P; Soyka, M, 2006) |
| "Carbamazepine has demonstrated safety, tolerability and efficacy in treatment of moderate to severe symptoms of alcohol withdrawal in the inpatient setting." | 2.46 | The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome. ( Barrons, R; Roberts, N, 2010) |
| " Dosage should be individualized, based on withdrawal severity measured by withdrawal scales, comorbid illness, and history of withdrawal seizures." | 2.40 | Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. ( Mayo-Smith, MF, 1997) |
| " Its pharmacological properties and side-effects are well known and very effective dosage schedules already exist." | 2.39 | [Carbamazepine in treatment of alcohol withdrawal syndrome--an overview of current research]. ( Thome, J; Vince, GH; Wiesbeck, GA, 1994) |
| "Delirium tremens is linked with a chronic depression of the central nervous system by alcohol and a compensatory hyperactivity of neurotransmitters." | 2.38 | [Delirium tremens. Recent neurophysiologic concepts and therapeutic outlook]. ( Meignan, ML, 1992) |
| "Most patients with mild withdrawal symptoms respond to non-pharmacological supportive care, except for those with a history of withdrawal seizures." | 1.28 | [Alcohol withdrawal--biological background, diagnosis and treatment]. ( Johnsen, J; Mørland, J, 1990) |
| "Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program." | 1.27 | Should alcohol withdrawal seizures be treated with anti-epileptic drugs? ( Hillbom, ME; Hjelm-Jäger, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (42.86) | 18.7374 |
| 1990's | 11 (39.29) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Bahji, A | 1 |
| Bach, P | 1 |
| Danilewitz, M | 1 |
| Crockford, D | 1 |
| El-Guebaly, N | 1 |
| Devoe, DJ | 1 |
| Saitz, R | 1 |
| Barrons, R | 1 |
| Roberts, N | 1 |
| Soyka, M | 1 |
| Schmidt, F | 1 |
| Schmidt, P | 1 |
| Helland, A | 1 |
| Skjøtskift, S | 1 |
| Sillanpää, ML | 1 |
| Hillbom, ME | 1 |
| Hjelm-Jäger, M | 1 |
| Flygenring, J | 1 |
| Hansen, J | 1 |
| Holst, B | 1 |
| Petersen, E | 1 |
| Sørensen, A | 1 |
| Sillanpää, M | 1 |
| Lemke, MR | 1 |
| Thome, J | 1 |
| Wiesbeck, GA | 1 |
| Vince, GH | 1 |
| Mueller, TI | 1 |
| Stout, RL | 1 |
| Rudden, S | 1 |
| Brown, RA | 1 |
| Gordon, A | 1 |
| Solomon, DA | 1 |
| Recupero, PR | 1 |
| Mayo-Smith, MF | 1 |
| Franz, M | 1 |
| Dlabal, H | 1 |
| Kunz, S | 1 |
| Ulferts, J | 1 |
| Gruppe, H | 1 |
| Gallhofer, B | 1 |
| Lier, A | 1 |
| Lier, G | 1 |
| Gallant, DM | 2 |
| Meignan, ML | 1 |
| Bokström, K | 2 |
| Balldin, J | 2 |
| Rommelspacher, H | 1 |
| Schmidt, LG | 1 |
| Helmchen, H | 1 |
| Johnsen, J | 1 |
| Mørland, J | 1 |
| Ballard, CG | 1 |
| Mohan, RN | 1 |
| Handy, S | 1 |
| von Albert, HH | 1 |
| Malcolm, R | 1 |
| Ballenger, JC | 1 |
| Sturgis, ET | 1 |
| Anton, R | 1 |
| Schmickaly, R | 1 |
| Kursawe, HK | 1 |
| Elton, M | 1 |
| Dittmar, G | 1 |
| Lincke, HO | 1 |
| Schulte, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| Acamprosate for Central Nervous System Hyperexcitability and Neuroadaptation in Alcohol Withdrawal[NCT00106106] | Phase 2 | 56 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 25
| Intervention | Ratio of glutamate to creatine (Mean) |
|---|---|
| Placebo | 1.350375 |
| Acamprosate | 1.166667 |
The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 4
| Intervention | Ratio of glutamate to creatine (Mean) |
|---|---|
| Placebo | 1.256772 |
| Acamprosate | 1.294178 |
7 reviews available for carbamazepine and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Carbamazepine; Diazepam; Female; Hu | 2022 |
The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome.
Topics: Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Anticonvulsants; Benzodiazepines; Carbamaz | 2010 |
[Carbamazepine in treatment of alcohol withdrawal syndrome--an overview of current research].
Topics: Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Dose-Response Relationship, Drug; Drug Admin | 1994 |
Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal.
Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Antipsychotic Agents; Benzodiazepines; Car | 1997 |
[Delirium tremens. Recent neurophysiologic concepts and therapeutic outlook].
Topics: Alcohol Withdrawal Delirium; Carbamazepine; Chlormethiazole; Clonidine; Ethanol; Haloperidol; Humans | 1992 |
[Pathobiochemistry and pharmacotherapy of alcohol withdrawal delirium].
Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Benzodiazepines; Brain; Carbamazepine; Chlormethia | 1991 |
[Therapy in alcoholic delirium].
Topics: Alcohol Withdrawal Delirium; Carbamazepine; Chlormethiazole; Diazepam; Haloperidol; Humans; Phenytoi | 1987 |
8 trials available for carbamazepine and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Efficacy and safety of outpatient alcohol detoxification with a combination of tiapride/carbamazepine: additional evidence.
Topics: Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Antipsychotic Age | 2006 |
Treatment of alcohol withdrawal symptoms in hospitalized patients. A randomized, double-blind comparison of carbamazepine (Tegretol) and barbital (Diemal).
Topics: Adult; Alcohol Withdrawal Delirium; Barbital; Barbiturates; Carbamazepine; Dose-Response Relationshi | 1984 |
A double-blind, placebo-controlled pilot study of carbamazepine for the treatment of alcohol dependence.
Topics: Adult; Affect; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Double-Blind | 1997 |
One more look at carbamazepine in the treatment of alcohol withdrawal.
Topics: Adolescent; Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Double-Blind Method | 1992 |
Double-blind controlled trial comparing carbamazepine to oxazepam treatment of alcohol withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Et | 1989 |
Improvements in treatment of alcohol withdrawal syndromes.
Topics: Alcohol Withdrawal Delirium; Carbamazepine; Double-Blind Method; Humans; Oxazepam; Psychoses, Alcoho | 1989 |
Treatment of alcohol abstinence symptoms with the alpha 2-agonist clonidine.
Topics: Adult; Alcohol Withdrawal Delirium; Carbamazepine; Chlorprothixene; Clinical Trials as Topic; Clonid | 1986 |
[Therapy of pre-delirium alcohol withdrawal syndrome. Results of a comparative study of carbamazepine and clomethiazole].
Topics: Adult; Alcohol Withdrawal Delirium; Carbamazepine; Chlormethiazole; Humans; Psychoses, Alcoholic | 1987 |
13 other studies available for carbamazepine and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
[Drug treatment of alcohol withdrawal].
Topics: Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Anticonvulsants; Benzodiazepines; Carbamaz | 2008 |
Alcoholism: treatment of alcohol withdrawal symptoms.
Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Barbiturate | 1982 |
Should alcohol withdrawal seizures be treated with anti-epileptic drugs?
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Chlormethiazol | 1984 |
Carbamazepine. Pharmacology and clinical uses.
Topics: Adult; Alcohol Withdrawal Delirium; Arrhythmias, Cardiac; Behavior; Carbamazepine; Child; Diabetes I | 1981 |
[Differential diagnostic-therapeutic use of Carbamazepine in alcohol withdrawal syndrome].
Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Benzodiazepines; Carbamazepine; Chlormethiazole; H | 1995 |
Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study.
Topics: Adult; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Anticonvulsants; Antipsychotic Agen | 2001 |
[Therapy of alcoholic withdrawal syndromes with carbamazepine].
Topics: Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Ethanol; Humans; Substance Withdrawal Syndro | 1979 |
A rating scale for assessment of alcohol withdrawal psychopathology (AWIP).
Topics: Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Chlormethiazole; Chlorprothixene; Clonidine; | 1992 |
[Alcohol withdrawal--biological background, diagnosis and treatment].
Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Antidepressive Agents; Antipsychotic Agent | 1990 |
Carbamazepine in alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Humans | 1991 |
[Delirium conditions. 2: Therapy].
Topics: Alcohol Withdrawal Delirium; Carbamazepine; Chlormethiazole; Delirium; Drug Therapy, Combination; Hu | 1990 |
[Therapy of delirium tremens].
Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Anti-Bacterial Agents; Benzodiazepines; Carbamazep | 1985 |
Alcohol withdrawal: clinical symptoms and management of the syndrome.
Topics: Alcohol Withdrawal Delirium; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Chlormethiazole; | 1986 |