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carbamazepine and Agranulocytosis

carbamazepine has been researched along with Agranulocytosis in 25 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

ExcerptRelevanceReference
"A 48-year-old man who is a known case of bipolar disorder was maintaining well on a combination of carbamazepine and quetiapine for 3 years until he developed fever, severe leucopenia and lymphadenopathy, along with significant loss of weight and appetite."8.02Carbamazepine-induced delayed-onset agranulocytosis in a case of bipolar disorder with Kikuchi's disease. ( Innamuri, R; Irudayaraj, C; Kattula, D, 2021)
"Carbamazepine-induced agranulocytosis (CIA) is a rare event."7.70[Carbamazepine-induced agranulocytosis. Apropos of 2 cases]. ( Banfi, L; Ceppi, M; Colzani, M; Guzzini, F; Morena, R; Novati, P, 1998)
"A chronic schizophrenic patient developed a fatal agranulocytosis 1 month after beginning to take carbamazepine for aggression."7.67Fatal agranulocytosis in a chronic schizophrenic patient treated with carbamazepine. ( Luchins, DJ, 1984)
"One hundred seventy-six children treated with carbamazepine for epilepsy were monitored over a 12-month period to determine the effects of carbamazepine on the hematologic system."7.67Hematologic monitoring in children with epilepsy treated with carbamazepine. ( Evans, OB; Gay, H; Parks, B; Swisher, A, 1989)
"Carbamazepine is a valuable drug in the treatment of trigeminal neuralgia and temporal lobe epilepsy."5.26Agranulocytosis associated with carbamazepine, and a positive reaction with anti-lymphoid leukaemia antiserum during recovery. ( Davies, J; Nunn, PP; Owens, CW; Parker, NE, 1980)
"A 48-year-old man who is a known case of bipolar disorder was maintaining well on a combination of carbamazepine and quetiapine for 3 years until he developed fever, severe leucopenia and lymphadenopathy, along with significant loss of weight and appetite."4.02Carbamazepine-induced delayed-onset agranulocytosis in a case of bipolar disorder with Kikuchi's disease. ( Innamuri, R; Irudayaraj, C; Kattula, D, 2021)
"Carbamazepine is a commonly used anticonvulsant agent, particularly in the management of partial seizures."3.67Leucopenia as an adverse reaction to carbamazepine therapy. ( Beran, RG; Rush, JA, 1984)
"A chronic schizophrenic patient developed a fatal agranulocytosis 1 month after beginning to take carbamazepine for aggression."3.67Fatal agranulocytosis in a chronic schizophrenic patient treated with carbamazepine. ( Luchins, DJ, 1984)
"One hundred seventy-six children treated with carbamazepine for epilepsy were monitored over a 12-month period to determine the effects of carbamazepine on the hematologic system."3.67Hematologic monitoring in children with epilepsy treated with carbamazepine. ( Evans, OB; Gay, H; Parks, B; Swisher, A, 1989)
" The findings of this study are comparable with those of other series assessing carbamazepine-associated adverse reactions in children and adults."2.37Carbamazepine side effects in children and adults. ( Pellock, JM, 1987)
"DRESS syndrome is a disorder that is unfamiliar to pediatricians."1.46[DRESS syndrome and agranulocytosis, a rare combination]. ( Abasq, C; Huet, F; Lavenant, P; Misery, L; Rioualen, S; Roue, JM, 2017)
"Carbamazepine is a valuable drug in the treatment of trigeminal neuralgia and temporal lobe epilepsy."1.26Agranulocytosis associated with carbamazepine, and a positive reaction with anti-lymphoid leukaemia antiserum during recovery. ( Davies, J; Nunn, PP; Owens, CW; Parker, NE, 1980)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199016 (64.00)18.7374
1990's6 (24.00)18.2507
2000's1 (4.00)29.6817
2010's1 (4.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Irudayaraj, C1
Innamuri, R1
Kattula, D1
Lavenant, P1
Roue, JM1
Huet, F1
Abasq, C1
Misery, L1
Rioualen, S1
Brain, C1
Mac Ardle, B1
Levin, S1
Rush, JA1
Beran, RG1
Luchins, DJ1
Owens, CW1
Parker, NE1
Nunn, PP1
Davies, J1
Hawson, GA1
Bain, BJ1
Whyte, I1
Junghan, U1
Albers, M1
Woggon, B1
Spickett, GP1
Gompels, MM1
Saunders, PW1
Banfi, L1
Ceppi, M1
Colzani, M1
Guzzini, F1
Morena, R1
Novati, P1
Cambon, S1
Rossi, P1
Miliani, Y1
Arnaud, S1
Albanèse, J1
Langbehn, DR1
Alexander, B2
Vaĭntrub, MIa1
Shapiro, IuL1
Mastrosimone, F1
Capo, G1
Colucci D'Amato, C1
Gerson, SL1
Lieberman, JA1
Friedenberg, WR1
Lee, D1
Marx, JJ1
Meltzer, H1
Sobotka, JL1
Cook, BL1
Joffe, RT1
Post, RM1
Evans, OB1
Gay, H1
Swisher, A1
Parks, B1
Balon, R1
Berchou, R1
Pellock, JM1
Servant, D1
Danel, T1
Goudemand, M1
Minich, PJ1
Young, WA1
Kamp, JS1
Crill, WE1

Reviews

4 reviews available for carbamazepine and Agranulocytosis

ArticleYear
A review of carbamazepine's hematologic reactions and monitoring recommendations.
    DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:12

    Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Carbamazepine; Child, Preschool; Female; Humans; Mal

1990
Hematologic side effects of psychotropic drugs.
    Psychosomatics, 1986, Volume: 27, Issue:2

    Topics: Agranulocytosis; Anemia, Aplastic; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents;

1986
Carbamazepine side effects in children and adults.
    Epilepsia, 1987, Volume: 28 Suppl 3

    Topics: Adult; Agranulocytosis; Anemia, Aplastic; Carbamazepine; Chemical and Drug Induced Liver Injury; Chi

1987
Drugs 5 years later: carbamazepine.
    Annals of internal medicine, 1973, Volume: 79, Issue:6

    Topics: Agranulocytosis; Anemia, Aplastic; Anticonvulsants; Bone Marrow; Bone Marrow Cells; Carbamazepine; D

1973

Other Studies

21 other studies available for carbamazepine and Agranulocytosis

ArticleYear
Carbamazepine-induced delayed-onset agranulocytosis in a case of bipolar disorder with Kikuchi's disease.
    BMJ case reports, 2021, Jun-30, Volume: 14, Issue:6

    Topics: Agranulocytosis; Bipolar Disorder; Carbamazepine; Histiocytic Necrotizing Lymphadenitis; Humans; Lym

2021
[DRESS syndrome and agranulocytosis, a rare combination].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2017, Volume: 24, Issue:8

    Topics: Agranulocytosis; Anticonvulsants; Carbamazepine; Child; Drug Hypersensitivity Syndrome; Epilepsies,

2017
Idiosyncratic reactions to carbamazepine mimicking viral infection in children.
    British medical journal (Clinical research ed.), 1984, Aug-11, Volume: 289, Issue:6441

    Topics: Adolescent; Agranulocytosis; Carbamazepine; Child; Diagnosis, Differential; Female; Humans; Infant;

1984
Leucopenia as an adverse reaction to carbamazepine therapy.
    The Medical journal of Australia, 1984, Mar-31, Volume: 140, Issue:7

    Topics: Adult; Agranulocytosis; Carbamazepine; Dose-Response Relationship, Drug; Female; Humans; Leukocyte C

1984
Fatal agranulocytosis in a chronic schizophrenic patient treated with carbamazepine.
    The American journal of psychiatry, 1984, Volume: 141, Issue:5

    Topics: Aggression; Agranulocytosis; Carbamazepine; Chronic Disease; Humans; Male; Middle Aged; Schizophreni

1984
Agranulocytosis associated with carbamazepine, and a positive reaction with anti-lymphoid leukaemia antiserum during recovery.
    Postgraduate medical journal, 1980, Volume: 56, Issue:659

    Topics: Agranulocytosis; Antigens, Surface; Carbamazepine; Humans; Immune Sera; Leukemia, Lymphoid; Male; Mi

1980
Agranulocytosis after administration of carbamazepine.
    The Medical journal of Australia, 1980, Jan-26, Volume: 1, Issue:2

    Topics: Agranulocytosis; Carbamazepine; Female; Humans; Middle Aged

1980
Increased risk of hematological side-effects in psychiatric patients treated with clozapine and carbamazepine?
    Pharmacopsychiatry, 1993, Volume: 26, Issue:6

    Topics: Agranulocytosis; Carbamazepine; Clozapine; Drug Interactions; Hematologic Diseases; Humans; Mental D

1993
Hypogammaglobulinaemia with absent B lymphocytes and agranulocytosis after carbamazepine treatment.
    Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 60, Issue:4

    Topics: Agranulocytosis; Anticonvulsants; B-Lymphocytes; Carbamazepine; Dysgammaglobulinemia; Humans; IgA De

1996
[Carbamazepine-induced agranulocytosis. Apropos of 2 cases].
    Recenti progressi in medicina, 1998, Volume: 89, Issue:10

    Topics: Aged; Aged, 80 and over; Agranulocytosis; Analgesics, Non-Narcotic; Anticonvulsants; Bone Marrow Exa

1998
[Severe agranulocytosis induced by carbamazepine (Tegretol)].
    Annales francaises d'anesthesie et de reanimation, 1999, Volume: 18, Issue:5

    Topics: Acinetobacter Infections; Adult; Agranulocytosis; Analgesics, Non-Narcotic; Anti-Bacterial Agents; A

1999
Increased risk of side-effects in psychiatric patients treated with clozapine and carbamazepine: a reanalysis.
    Pharmacopsychiatry, 2000, Volume: 33, Issue:5

    Topics: Agranulocytosis; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Clozapine; Drug Interactions;

2000
[Neutropenia in epilepsy patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1979, Volume: 79, Issue:3

    Topics: Adolescent; Adult; Agranulocytosis; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epile

1979
[The use of lithium salts in trigeminal neuralgia in prevention of neutropenia due to carbamazepine. Preliminary considerations].
    Acta neurologica. Quaderni, 1979, Volume: 39

    Topics: Aged; Agranulocytosis; Carbamazepine; Female; Humans; Lithium; Male; Middle Aged; Neutropenia; Risk;

1979
Polypharmacy in fatal clozapine-associated agranulocytosis.
    Lancet (London, England), 1991, Jul-27, Volume: 338, Issue:8761

    Topics: Agranulocytosis; Carbamazepine; Clozapine; Humans; Male; Middle Aged; Monitoring, Physiologic; Schiz

1991
Lithium and carbamazepine-induced agranulocytosis.
    The American journal of psychiatry, 1989, Volume: 146, Issue:3

    Topics: Agranulocytosis; Carbamazepine; Humans; Leukocyte Count; Leukopenia; Lithium; Lithium Carbonate; Neu

1989
Hematologic monitoring in children with epilepsy treated with carbamazepine.
    Journal of child neurology, 1989, Volume: 4, Issue:4

    Topics: Agranulocytosis; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans

1989
Lithium therapy in carbamazepine-induced agranulocytosis.
    The American journal of psychiatry, 1988, Volume: 145, Issue:3

    Topics: Adult; Agranulocytosis; Bipolar Disorder; Carbamazepine; Drug Therapy, Combination; Humans; Lithium;

1988
Severe hematologic and neurologic reaction to carbamazepine.
    Canadian Medical Association journal, 1985, May-01, Volume: 132, Issue:9

    Topics: Aged; Agranulocytosis; Carbamazepine; Central Nervous System Diseases; Hematologic Diseases; Humans;

1985
[Responsibility of the physician in prescribing Tegretol].
    Nederlands tijdschrift voor geneeskunde, 1985, Mar-30, Volume: 129, Issue:13

    Topics: Agranulocytosis; Carbamazepine; Drug Prescriptions; Humans; Jurisprudence; Netherlands

1985
Carbamazepine (Tegretol).
    The Medical letter on drugs and therapeutics, 1968, Jun-28, Volume: 10, Issue:13

    Topics: Agranulocytosis; Anemia, Aplastic; Blood Platelet Disorders; Carbamazepine; Dibenzazepines; Hematolo

1968