Page last updated: 2024-10-24

carbamazepine and Aggression

carbamazepine has been researched along with Aggression in 78 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both."9.14Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. ( Aga, O; Cvancarova, M; Engedal, K; Olsen, IC; Selbaek, G; Sommer, OH, 2009)
"Oxcarbazepine appears to benefit adults with clinically significant impulsive aggression."9.11Oxcarbazepine in patients with impulsive aggression: a double-blind, placebo-controlled trial. ( Mattes, JA, 2005)
"The aim of this study was to assess the effects of withdrawal from placebo and carbamazepine administered for agitation associated with dementia and to assess safety, tolerability, and efficacy of subsequent ongoing carbamazepine therapy."9.09Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, LJ; Lanning, B; Podgorski, CA; Tariot, PN, 1999)
"The efficacy, safety, and tolerability of carbamazepine in the treatment of agitation and aggression associated with dementia were assessed."9.08Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, L; Patel, S; Podgorski, CA; Tariot, PN, 1998)
" Risperidone is a widely accessible antipsychotic that can be used to manage psychosis-induced aggression or agitation."8.98Risperidone for psychosis-induced aggression or agitation (rapid tranquillisation). ( Adams, CE; Ahmed, U; Hussein, M; Miramontes, K; Ostinelli, EG; Rehman, FU, 2018)
"A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control."7.75Carbamazepine-induced hyperammonemia. ( Adams, EN; Lizer, MH; Marks, A, 2009)
"Valproate and carbamazepine (CAR) have been proposed as adjunct alternatives for the control of aggression in psychiatric patients, although no definite conclusions have been reached."7.74Effects of sodium valproate and carbamazepine on food competition aggression in pigeons. ( Ahumada, M; Fachinelli, C; Fachinellizz, JM; Rodríguez-Echandía, EL; Torrecilla, M, 2007)
"Divalproex (DVP) and oxcarbazepine (OXC) are used to treat pediatric bipolar disorder (PBPD) with severe aggression but these agents have not been compared in head to head trials."7.73A comparison of divalproex and oxcarbazepine in aggressive youth with bipolar disorder. ( Fleisher, CA; Gonzalez-Heydrich, J; Korndörfer, SR; MacMillan, CM; Mezzacappa, E; Rao, S, 2006)
"A chronic schizophrenic patient developed a fatal agranulocytosis 1 month after beginning to take carbamazepine for aggression."7.67Fatal agranulocytosis in a chronic schizophrenic patient treated with carbamazepine. ( Luchins, DJ, 1984)
"Carbamazepine was administered in an open pilot study to 13 patients with primary degenerative dementia characterized by aggressive and assaultive behavior refractory to conventional treatment."7.67A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. ( Patterson, JF, 1988)
"Carbamazepine has been utilized both as an anticonvulsant and as a psychotropic drug for the treatment of complex partial seizures and various mood and other emotional disorders such as the episodic dyscontrol syndrome."5.27Carbamazepine regulates feline aggression elicited from the midbrain periaqueductal gray. ( Edinger, HM; Shaikh, MB; Siegel, A, 1988)
"Carbamazepine is an interesting new drug, with both anticonvulsant and psychotropic properties, for which both the behavioral effects and pharmacological actions have been defined."5.26Carbamazepine in the dyscontrol syndrome associated with limbic system dysfunction. ( Dermer, SW; Tunks, ER, 1977)
"To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both."5.14Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. ( Aga, O; Cvancarova, M; Engedal, K; Olsen, IC; Selbaek, G; Sommer, OH, 2009)
"Oxcarbazepine appears to benefit adults with clinically significant impulsive aggression."5.11Oxcarbazepine in patients with impulsive aggression: a double-blind, placebo-controlled trial. ( Mattes, JA, 2005)
"The aim of this study was to assess the effects of withdrawal from placebo and carbamazepine administered for agitation associated with dementia and to assess safety, tolerability, and efficacy of subsequent ongoing carbamazepine therapy."5.09Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, LJ; Lanning, B; Podgorski, CA; Tariot, PN, 1999)
"The efficacy, safety, and tolerability of carbamazepine in the treatment of agitation and aggression associated with dementia were assessed."5.08Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. ( Cox, C; Erb, R; Irvine, C; Jakimovich, L; Patel, S; Podgorski, CA; Tariot, PN, 1998)
" Risperidone is a widely accessible antipsychotic that can be used to manage psychosis-induced aggression or agitation."4.98Risperidone for psychosis-induced aggression or agitation (rapid tranquillisation). ( Adams, CE; Ahmed, U; Hussein, M; Miramontes, K; Ostinelli, EG; Rehman, FU, 2018)
"To review and summarize the currently available data on the use of anticonvulsant mood stabilizers (carbamazepine, valproic acid, gabapentin, lamotrigine, topiramate) in the treatment of behavioral and psychological symptoms of dementia (BPSD); to determine whether these medications can be recommended for routine clinical use."4.84Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. ( Konovalov, S; Muralee, S; Tampi, RR, 2008)
"A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control."3.75Carbamazepine-induced hyperammonemia. ( Adams, EN; Lizer, MH; Marks, A, 2009)
"Valproate and carbamazepine (CAR) have been proposed as adjunct alternatives for the control of aggression in psychiatric patients, although no definite conclusions have been reached."3.74Effects of sodium valproate and carbamazepine on food competition aggression in pigeons. ( Ahumada, M; Fachinelli, C; Fachinellizz, JM; Rodríguez-Echandía, EL; Torrecilla, M, 2007)
"Divalproex (DVP) and oxcarbazepine (OXC) are used to treat pediatric bipolar disorder (PBPD) with severe aggression but these agents have not been compared in head to head trials."3.73A comparison of divalproex and oxcarbazepine in aggressive youth with bipolar disorder. ( Fleisher, CA; Gonzalez-Heydrich, J; Korndörfer, SR; MacMillan, CM; Mezzacappa, E; Rao, S, 2006)
"A chronic schizophrenic patient developed a fatal agranulocytosis 1 month after beginning to take carbamazepine for aggression."3.67Fatal agranulocytosis in a chronic schizophrenic patient treated with carbamazepine. ( Luchins, DJ, 1984)
"Carbamazepine was administered in an open pilot study to 13 patients with primary degenerative dementia characterized by aggressive and assaultive behavior refractory to conventional treatment."3.67A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. ( Patterson, JF, 1988)
"Carbamazepine was not superior to placebo at optimal daily doses ranging from 400 to 800 mg, mean 683 mg, at serum levels of 4."2.68Carbamazepine in aggressive children with conduct disorder: a double-blind and placebo-controlled study. ( Armenteros, JL; Campbell, M; Cueva, JE; Overall, JE; Perry, R; Small, AM, 1996)
"The diagnosis of attention deficit disorder predicted preferential response to propranolol, and a diagnosis of intermittent explosive disorder predicted preferential response to carbamazepine."2.67Comparative effectiveness of carbamazepine and propranolol for rage outbursts. ( Mattes, JA, 1990)
" Vegetative and neurotoxic effects most commonly occur in the beginning of therapy, after increasing the dosage and in case of intoxication."2.38[Carbamazepine in the treatment of psychiatric diseases: effects and side effects]. ( Rittmannsberger, H, 1990)
"Carbamazepine is a tricyclic compound structurally related to imipramine that has been used since the 1960's for the treatment of trigeminal neuralgias and then approved as an anticonvulsant in the U."2.37Carbamazepine in psychiatry: a review. ( Beaudry, P; Israel, M, 1988)
"Early treatment of epilepsy is warranted to avoid possible severe consequences."1.39Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013)
"Citalopram was the most preferred antidepressant and Carbamazepine, the most preferred mood stabilizer/antiepileptic."1.35Use of medication for the management of behavior problems among adults with intellectual disabilities: a clinicians' consensus survey. ( Deb, S; Unwin, GL, 2008)
"Carbamazepine has been used in the treatment of temporal lobe epilepsy since 1963."1.27Carbamazepine in the treatment of aggressive behavior in schizophrenic patients: a case report. ( Dupont, D; Yassa, R, 1983)
"Carbamazepine is an interesting new drug, with both anticonvulsant and psychotropic properties, for which both the behavioral effects and pharmacological actions have been defined."1.26Carbamazepine in the dyscontrol syndrome associated with limbic system dysfunction. ( Dermer, SW; Tunks, ER, 1977)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199031 (39.74)18.7374
1990's24 (30.77)18.2507
2000's17 (21.79)29.6817
2010's6 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ostinelli, EG1
Hussein, M1
Ahmed, U1
Rehman, FU1
Miramontes, K1
Adams, CE1
Silva, EF1
Silva, AI1
Asth, L1
Souza, LS1
Zaveri, NT1
Guerrini, R1
Calo', G1
Ruzza, C1
Gavioli, EC1
Rapinesi, C1
Del Casale, A1
Serata, D1
Kotzalidis, GD1
Scatena, P1
Muzi, A1
Lazanio, S1
Savoja, V1
Carbonetti, P1
Fensore, C1
Ferracuti, S1
Angeletti, G1
Tatarelli, R1
Girardi, P1
Meyer, JM1
Cummings, MA1
Proctor, G1
Stahl, SM1
Pae, CU1
Sommer, OH1
Aga, O1
Cvancarova, M1
Olsen, IC1
Selbaek, G1
Engedal, K1
Adams, EN1
Marks, A1
Lizer, MH1
Niederhofer, H1
Mattes, JA5
Richard, I1
Perrouin-Verbe, B1
Rome, J1
Bernat, C1
Mathé, JF1
Gaudino, MP1
Smith, MJ1
Matthews, DT1
Cummings, MR1
Miller, BD1
Stanford, MS1
Helfritz, LE1
Conklin, SM1
Villemarette-Pittman, NR1
Greve, KW2
Adams, D2
Houston, RJ1
MacMillan, CM1
Korndörfer, SR1
Rao, S1
Fleisher, CA1
Mezzacappa, E1
Gonzalez-Heydrich, J1
Fachinelli, C1
Ahumada, M1
Fachinellizz, JM1
Torrecilla, M1
Rodríguez-Echandía, EL1
Konovalov, S1
Muralee, S1
Tampi, RR1
Nagata, T1
Harada, D1
Aoki, K1
Kada, H1
Miyata, H1
Kasahara, H1
Nakayama, K1
Unwin, GL1
Deb, S1
Sheard, MH2
Rapport, MD1
Sonis, WA1
Fialkov, MJ1
Matson, JL1
Kazdin, AE1
Hoaken, PC1
Tannhauser, SL1
Tannhauser, M1
Barros, HM1
Corso, CO1
Pinto-Netto, LM1
Yassa, R1
Dupont, D1
Luchins, DJ1
Bhatara, VS1
Carrera, J1
Young, JL1
Hillbrand, M2
Zayas, EM1
Grossberg, GT1
Mintzer, JE1
Brawman-Mintzer, O1
Chatham-Showalter, PE1
Amen, DG1
Stubblefield, M1
Carmicheal, B1
Thisted, R1
Cueva, JE1
Overall, JE1
Small, AM2
Armenteros, JL1
Perry, R1
Campbell, M3
Kafantaris, V2
Lee, DO1
Magee, H1
Winny, G1
Samuel, R1
Pollack, S1
Tariot, PN2
Erb, R2
Podgorski, CA2
Cox, C2
Patel, S1
Jakimovich, L1
Irvine, C2
Weller, EB1
Rowan, A1
Elia, J1
Weller, RA1
Swann, AC1
Alderman, N1
Davies, JA1
Jones, C1
McDonnel, P1
Jakimovich, LJ1
Lanning, B1
Azouvi, P1
Jokic, C1
Attal, N1
Denys, P1
Markabi, S1
Bussel, B1
Teitelbaum, M1
Vespignani, H1
Roger, J1
Brieden, T1
Ujeyl, M1
Naber, D1
Tunks, ER1
Dermer, SW1
Sugarman, P1
Anfinson, T1
Tu, JB1
Hartridge, C1
Izawa, J1
Padron-Gayol, MV1
Locascio, JJ1
Rosenberg, CR1
Lewin, J1
Sumners, D1
Alarcon, RD1
Johnson, BR1
Lucas, JP1
Wong, SE1
Floyd, J1
Innocent, AJ1
Woolsey, JE1
Rittmannsberger, H1
Shah, AK1
Marin, DB1
Greenwald, BS1
Foster, HG1
Chi, CC1
Fujiwara, Y1
Takeda, T1
Kazahaya, Y1
Otsuki, S1
Sandyk, R1
Deutsch, SI1
Risse, SC1
Barnes, R1
Ortiz, A1
Gershon, S1
Conacher, GN1
Israel, M1
Beaudry, P1
Yatham, LN1
McHale, PA1
Buck, OD1
Havey, P1
Shaikh, MB1
Edinger, HM1
Siegel, A1
Pleak, RR1
Birmaher, B1
Gavrilescu, A1
Abichandani, C1
Williams, DT1
Patterson, JF1
Weaver, DF1
Camfield, P1
Fraser, A1
Leong, GB1
Silva, JA1
Gupta, BK1
Fish, DN1
Yerevanian, BI1
Oehler, J1
Jähkel, M1
Schmidt, J1
Nakao, K1
Higashio, T1
Inukai, T1
Lehmann, HE1
Ban, TA1
Montanini, R1
Mastruzzo, A1
Giovannucci, M1
Mourot, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Oxcarbazepine in the Treatment of Agitation / Aggression in Dementia (OBAD) - An Eight Week Prospective, Randomized, Double-Blind, Placebo-Controlled, Multi Center Trial. A Phase III Study[NCT00145691]Phase 3100 participants Interventional2005-09-30Completed
Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression: A 42-Day, Single-Site, Forced-Titration, Parallel Group, Randomized, Double-Blind, Placebo Controlled Trial[NCT00621751]70 participants (Actual)Interventional2008-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinicians Global Impression of Change

Study physician's impression of change since study onset. Clinicians Global Impressions of Change (CGI) is a sensitive, standardized tool to assess psychopharmacologic treatment response completed by the study physician. The Global Improvement (GI) CGI subscale documented the clinician's impression of change. The GI uses a 7-point scale to assess beneficial and negative effects. Low GI values (1 -3) indicate improvement; higher values (4-7) represent worsening. (NCT00621751)
Timeframe: 42 days

Interventionunits on a scale (Mean)
Carbamazepine3.1
Placebo2.9

Global Impression of Change -- Observer

Global Impression of Change (GIC) is a 5-item Likert Scale rated participants and observer impression of change in the person with TBI. Responses range 1 = much improved to 5 = much worse. (NCT00621751)
Timeframe: 42 days

Interventionunits on a scale (Mean)
Carbamazepine3.3
Placebo3.1

Global Impression of Change -- Participant

Global Impression of Change (GIC) is a 5-item Likert Scale rated participants and observer impression of change in the person with TBI. Responses range 1 = much improved to 5 = much worse. (NCT00621751)
Timeframe: Day-42

Interventionscore on a scale (Mean)
Carbamazepine3.1
Placebo3.1

Neuropsychiatric Inventory Irritability-Aggression Domains Composite Measure -- Observer

Neuropsychiatry Inventory-Irritability (NPI-I) & Aggression domains (NPI-A): NPI is a 40-item assessment of 12 behavioral domains (NPI-I & NPI-A domains used in this study). The most problematic aspect of each domain is graded for severity (1=mild, to 3=severe) and frequency (1-4 with 4 representing highest frequency); the domain scores (0-12) are the product of severity and frequency. To best reflect treatment target intent and meet parametric statistical method criteria, the primary outcome was a composite measure of observer-rated NPI-I & -A domains transformed to a Rasch logit scale running from 0 (best) to 100 (worse) units (i.e., observer-rated NPI-I/A Rasch construct scores). Mean day-42 observer-rated NPI-I/A Rasch construct scores were compared between placebo vs. carbamazepine using ANCOVA with baseline score as covariate. (NCT00621751)
Timeframe: 42 days

Interventionscore on a scale (Least Squares Mean)
Carbamazepine37.7
Placebo36.7

Neuropsychiatric Inventory Irritability-Aggression Domains Composite Measure Completed by Participant [Time Frame: 42 Days]

Neuropsychiatry Inventory-Irritability (NPI-I) & Aggression domains (NPI-A): NPI is a 40-item assessment of 12 behavioral domains (NPI-I & NPI-A domains used in this study). The most problematic aspect of each domain is graded for severity (1=mild, to 3=severe) and frequency (1-4 with 4 representing highest frequency); the domain scores (0-12) are the product of severity and frequency. To best reflect treatment target intent and meet parametric statistical method criteria, a composite measure of participant-rated NPI-I & -A domains transformed to a Rasch logit scale running from 0 (best) to 100 (worse) units (i.e., participant-rated NPI-I/A Rasch construct scores). Mean day-42 participant-rated NPI-I/A Rasch construct scores were compared between placebo vs. CBZ using ANCOVA with baseline score as covariate. (NCT00621751)
Timeframe: Day 42

Interventionscore on a scale (Least Squares Mean)
Carbamazepine37.5
Placebo36.4

Proportion of Participants With Minimal Clinically Important Difference -- Observer Rating

Proportion of participants with Minimal Clinically Important Difference (MCID) on Neuropsychiatric Inventory Irritability-Aggression Composite Measure completed by Observer. Specifically, the proportion of participants that experienced a decrease of > 1 (MCID) in the NPI-I/A Rasch construct score (i.e., participants that are considered to have meaningful reduction in irritability/aggression) from baseline to day-42 between the groups using a chi-square test. MCID was defined as 0.5 times the standard deviation of baseline scores. (NCT00621751)
Timeframe: 42-day

InterventionParticipants (Count of Participants)
Carbamazepine20
Placebo26

Proportion of Participants With Minimal Clinically Important Difference (MCID) -- Participant

Proportion of participants with Minimal Clinically Important Difference (MCID) on Neuropsychiatric Inventory Irritability-Aggression Composite Measure completed by Participant. Specifically, the proportion of participants that experienced a decrease of > 1 (MCID) in the NPI-I/A Rasch construct score (i.e., participants that are considered to have meaningful reduction in irritability/aggression) from baseline to day-42 between the groups using a chi-square test. MCID was defined as 0.5 times the standard deviation of baseline scores. (NCT00621751)
Timeframe: Day-42

InterventionParticipants (Count of Participants)
Carbamazepine21
Placebo16

Reviews

18 reviews available for carbamazepine and Aggression

ArticleYear
Risperidone for psychosis-induced aggression or agitation (rapid tranquillisation).
    The Cochrane database of systematic reviews, 2018, 04-10, Volume: 4

    Topics: Administration, Oral; Aggression; Antipsychotic Agents; Carbamazepine; Humans; Oxcarbazepine; Psycho

2018
Psychopharmacology of Persistent Violence and Aggression.
    The Psychiatric clinics of North America, 2016, Volume: 39, Issue:4

    Topics: Aggression; Antimanic Agents; Antipsychotic Agents; Brain Injuries, Traumatic; Carbamazepine; Clozap

2016
[Pharmacological treatment of post-traumatic behavioural disorders].
    Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique, 2003, Volume: 46, Issue:1

    Topics: Adrenergic beta-Antagonists; Aggression; Anti-Anxiety Agents; Antidepressive Agents; Antimanic Agent

2003
Pharmacologic management of behavioral instability in medically ill pediatric patients.
    Current opinion in pediatrics, 2004, Volume: 16, Issue:5

    Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Analgesics, Non-Narcotic; Behavior Therapy; Behav

2004
Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review.
    International psychogeriatrics, 2008, Volume: 20, Issue:2

    Topics: Aggression; Amines; Anticonvulsants; Carbamazepine; Cognition Disorders; Cyclohexanecarboxylic Acids

2008
Clinical pharmacology of aggressive behavior.
    Clinical neuropharmacology, 1984, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Aggression; Anger; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; C

1984
Carbamazepine lowers aggression: a review.
    The Bulletin of the American Academy of Psychiatry and the Law, 1994, Volume: 22, Issue:1

    Topics: Aggression; Carbamazepine; Epilepsy; Humans; Male; Mental Disorders

1994
Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: toward a treatment approach.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 7

    Topics: Aged; Aggression; Antipsychotic Agents; Anxiety Disorders; Behavior Therapy; Buspirone; Carbamazepin

1996
Aggressive behavior in patients with attention-deficit/hyperactivity disorder, conduct disorder, and pervasive developmental disorders.
    The Journal of clinical psychiatry, 1999, Volume: 60 Suppl 15

    Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Child D

1999
Treatment of aggression in patients with bipolar disorder.
    The Journal of clinical psychiatry, 1999, Volume: 60 Suppl 15

    Topics: Aggression; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Combined Modality Therapy; Drug T

1999
Psychopharmacological treatment of aggression in schizophrenic patients.
    Pharmacopsychiatry, 2002, Volume: 35, Issue:3

    Topics: Adrenergic beta-Antagonists; Aggression; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Ca

2002
[Carbamazepine in the treatment of psychiatric diseases: effects and side effects].
    Wiener medizinische Wochenschrift (1946), 1990, Aug-15, Volume: 140, Issue:15

    Topics: Affective Disorders, Psychotic; Aggression; Alcoholism; Carbamazepine; Humans; Mental Disorders; Psy

1990
Pharmacologic treatment of agitation associated with dementia.
    Journal of the American Geriatrics Society, 1986, Volume: 34, Issue:5

    Topics: Affective Symptoms; Aged; Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antipsychotic Agents;

1986
The future of neuroleptic psychopharmacology.
    The Journal of clinical psychiatry, 1986, Volume: 47 Suppl

    Topics: Acute Disease; Aggression; Alprazolam; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Clinica

1986
Clinical pharmacology of aggressive behavior.
    Clinical neuropharmacology, 1988, Volume: 11, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aggression; Carbamazepine; Central Nervous System St

1988
Carbamazepine in psychiatry: a review.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1988, Volume: 33, Issue:7

    Topics: Aggression; Carbamazepine; Humans; Mental Disorders; Mood Disorders

1988
Carbamazepine in the treatment of aggression: a case report and a review of the literature.
    Acta psychiatrica Scandinavica, 1988, Volume: 78, Issue:2

    Topics: Adolescent; Aggression; Carbamazepine; Epilepsy, Temporal Lobe; Humans; Kindling, Neurologic; Limbic

1988
Psychopharmacology of temper outbursts. A review.
    The Journal of nervous and mental disease, 1986, Volume: 174, Issue:8

    Topics: Adolescent; Aggression; Anger; Animals; Carbamazepine; Child; Clinical Trials as Topic; Double-Blind

1986

Trials

11 trials available for carbamazepine and Aggression

ArticleYear
Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia.
    Dementia and geriatric cognitive disorders, 2009, Volume: 27, Issue:2

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Anticonvulsants; Carbamazepine; Dementia; De

2009
A comparison of anticonvulsants in the treatment of impulsive aggression.
    Experimental and clinical psychopharmacology, 2005, Volume: 13, Issue:1

    Topics: Adult; Aggression; Anticonvulsants; Carbamazepine; Double-Blind Method; Female; Humans; Impulsive Be

2005
Oxcarbazepine in patients with impulsive aggression: a double-blind, placebo-controlled trial.
    Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:6

    Topics: Adult; Aggression; Anticonvulsants; Carbamazepine; Disruptive, Impulse Control, and Conduct Disorder

2005
Carbamazepine in aggressive children with conduct disorder: a double-blind and placebo-controlled study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1996, Volume: 35, Issue:4

    Topics: Aggression; Carbamazepine; Child; Child Behavior Disorders; Double-Blind Method; Female; Humans; Mal

1996
Efficacy and tolerability of carbamazepine for agitation and aggression in dementia.
    The American journal of psychiatry, 1998, Volume: 155, Issue:1

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Carbamazepine; Dementia; Dementia, Vascular;

1998
Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:10

    Topics: Aggression; Anticonvulsants; Brief Psychiatric Rating Scale; Carbamazepine; Dementia; Drug Administr

1999
Comparative effectiveness of carbamazepine and propranolol for rage outbursts.
    The Journal of neuropsychiatry and clinical neurosciences, 1990,Spring, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Aggression; Antisocial Personality Disorder; Attention Deficit Disorder with Hype

1990
Efficacy of carbamazepine in assaultive patients with frontal lobe dysfunction.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:6

    Topics: Adult; Affect; Aggression; Carbamazepine; Cognition Disorders; Electroencephalography; Frontal Lobe;

1989
The future of neuroleptic psychopharmacology.
    The Journal of clinical psychiatry, 1986, Volume: 47 Suppl

    Topics: Acute Disease; Aggression; Alprazolam; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Clinica

1986
Psychopharmacology of temper outbursts. A review.
    The Journal of nervous and mental disease, 1986, Volume: 174, Issue:8

    Topics: Adolescent; Aggression; Anger; Animals; Carbamazepine; Child; Clinical Trials as Topic; Double-Blind

1986
Studies with new drugs in the treatment of convulsive disorders.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1968, Volume: 1, Issue:3

    Topics: Adult; Aggression; Anticonvulsants; Anxiety; Carbamazepine; Clinical Trials as Topic; Diazepam; Dibe

1968

Other Studies

51 other studies available for carbamazepine and Aggression

ArticleYear
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.
    Behavioural brain research, 2019, 01-01, Volume: 356

    Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Bipolar Disorder; Carbamazepine; Cycloheptanes; De

2019
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
    Brain injury, 2013, Volume: 27, Issue:7-8

    Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries

2013
Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions.
    Psychiatry and clinical neurosciences, 2008, Volume: 62, Issue:4

    Topics: Aggression; Anticonvulsants; Benzodiazepines; Carbamazepine; Cerebral Infarction; Disruptive, Impuls

2008
Carbamazepine-induced hyperammonemia.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, Aug-15, Volume: 66, Issue:16

    Topics: Adult; Aggression; Akathisia, Drug-Induced; Antimanic Agents; Bipolar Disorder; Carbamazepine; Human

2009
Combining carbamazepine, neuroleptics and acetylcholinesterase inhibitors with methylphenidate only reduces adverse side effects, but is less effective than a combination with atomoxetine.
    Medical hypotheses, 2011, Volume: 76, Issue:5

    Topics: Aggression; Antipsychotic Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperac

2011
Medications for aggressiveness in prison: focus on oxcarbazepine.
    The journal of the American Academy of Psychiatry and the Law, 2012, Volume: 40, Issue:2

    Topics: Aggression; Anticonvulsants; Carbamazepine; Humans; Mental Disorders; Oxcarbazepine; Prisoners

2012
Use of oxcarbazepine for treatment-resistant aggression.
    Psychiatric services (Washington, D.C.), 2003, Volume: 54, Issue:8

    Topics: Adolescent; Adolescent Behavior; Aggression; Anticonvulsants; Attention Deficit and Disruptive Behav

2003
A comparison of divalproex and oxcarbazepine in aggressive youth with bipolar disorder.
    Journal of psychiatric practice, 2006, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aggression; Antidepressive Agents; Bipolar Disorder; Carbamazepine; Child; Drug A

2006
Effects of sodium valproate and carbamazepine on food competition aggression in pigeons.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:6

    Topics: Aggression; Animals; Antimanic Agents; Carbamazepine; Columbidae; Competitive Behavior; Feeding Beha

2007
Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions.
    Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:6

    Topics: Aggression; Antimanic Agents; Benzodiazepines; Carbamazepine; Cerebral Infarction; Drug Resistance;

2007
Use of medication for the management of behavior problems among adults with intellectual disabilities: a clinicians' consensus survey.
    American journal of mental retardation : AJMR, 2008, Volume: 113, Issue:1

    Topics: Adult; Aggression; Antipsychotic Agents; Attitude of Health Personnel; Autistic Disorder; Carbamazep

2008
Carbamazepine and behavior therapy for aggressive behavior. Treatment of a mentally retarded, postencephalitic adolescent with seizure disorder.
    Behavior modification, 1983, Volume: 7, Issue:2

    Topics: Adolescent; Aggression; Behavior Therapy; Carbamazepine; Combined Modality Therapy; Encephalitis; Ep

1983
Carbamazepine in the treatment of aggressive behavior in schizophrenic patients: a case report.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1984, Volume: 29, Issue:3

    Topics: Adult; Aggression; Bipolar Disorder; Carbamazepine; Humans; Male; Schizophrenia, Paranoid

1984
Effects of carbamazepine or imipramine alone or in association with amphetamine on the fighting time of REM sleep-deprived rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1984, Volume: 17, Issue:2

    Topics: Aggression; Animals; Carbamazepine; Dextroamphetamine; Humans; Imipramine; Male; Rats; Rats, Inbred

1984
Carbamazepine in the treatment of aggressive behavior in schizophrenic patients: a case report.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1983, Volume: 28, Issue:7

    Topics: Adult; Aggression; Carbamazepine; Combined Modality Therapy; Drug Therapy, Combination; Electroconvu

1983
Fatal agranulocytosis in a chronic schizophrenic patient treated with carbamazepine.
    The American journal of psychiatry, 1984, Volume: 141, Issue:5

    Topics: Aggression; Agranulocytosis; Carbamazepine; Chronic Disease; Humans; Male; Middle Aged; Schizophreni

1984
Medications for aggressiveness.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1994, Volume: 33, Issue:2

    Topics: Aggression; Carbamazepine; Child; Child Behavior Disorders; Clonidine; Electroencephalography; Hallu

1994
Treating the agitated Alzheimer patient.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 7

    Topics: Adrenergic beta-Antagonists; Aged; Aggression; Alzheimer Disease; Antipsychotic Agents; Buspirone; C

1996
Carbamazepine for combativeness in acute traumatic brain injury.
    The Journal of neuropsychiatry and clinical neurosciences, 1996,Winter, Volume: 8, Issue:1

    Topics: Accidents, Traffic; Adult; Aggression; Brain Injuries; Carbamazepine; Critical Care; Female; Humans;

1996
Brain SPECT findings and aggressiveness.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1996, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Aged; Aggression; Basal Ganglia; Brain; Carbamazepine; Case-Control Studies; Dang

1996
Assessment of children with the overt aggression scale.
    The Journal of neuropsychiatry and clinical neurosciences, 1996,Spring, Volume: 8, Issue:2

    Topics: Aggression; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Female; Haloperidol; H

1996
Reduction of severe aggressive behaviour in acquired brain injury: case studies illustrating clinical use of the OAS-MNR in the management of challenging behaviours.
    Brain injury, 1999, Volume: 13, Issue:9

    Topics: Adult; Aggression; Antimanic Agents; Behavior Therapy; Brain Injury, Chronic; Carbamazepine; Combine

1999
Carbamazepine in agitation and aggressive behaviour following severe closed-head injury: results of an open trial.
    Brain injury, 1999, Volume: 13, Issue:10

    Topics: Adult; Aged; Aggression; Anger; Antimanic Agents; Carbamazepine; Dose-Response Relationship, Drug; F

1999
Oxcarbazepine in bipolar disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2001, Volume: 40, Issue:9

    Topics: Affect; Aggression; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Child; D

2001
Treatment of features of Obsessive-Compulsive Personality Disorder using carbamazepine.
    Psychiatry and clinical neurosciences, 2002, Volume: 56, Issue:2

    Topics: Aggression; Anticonvulsants; Attention; Carbamazepine; Humans; Male; Middle Aged; Motivation; Obsess

2002
[Medico-legal aspects of temporal lobe epilepsy in prison].
    Revue neurologique, 2002, Volume: 158, Issue:4

    Topics: Adult; Aggression; Anticonvulsants; Carbamazepine; Epilepsy, Temporal Lobe; Hallucinations; Health S

2002
Carbamazepine in the dyscontrol syndrome associated with limbic system dysfunction.
    The Journal of nervous and mental disease, 1977, Volume: 164, Issue:1

    Topics: Adult; Aggression; Agonistic Behavior; Brain Diseases; Carbamazepine; Electroencephalography; Female

1977
Carbamazepine and episodic dyscontrol.
    The British journal of psychiatry : the journal of mental science, 1992, Volume: 161

    Topics: Adult; Aggression; Brain Damage, Chronic; Carbamazepine; Epilepsy; Humans; Male; Violence

1992
Pharmacologic management of aggression and violence.
    Iowa medicine : journal of the Iowa Medical Society, 1992, Volume: 82, Issue:9

    Topics: Adrenergic beta-Antagonists; Aggression; Antipsychotic Agents; Benzodiazepines; Carbamazepine; Contr

1992
Psychopharmacogenetic aspects of Prader-Willi syndrome.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:6

    Topics: Adolescent; Aggression; Appetite Depressants; Behavior Therapy; Carbamazepine; Combined Modality The

1992
Carbamazepine in hospitalized aggressive conduct disorder children: an open pilot study.
    Psychopharmacology bulletin, 1992, Volume: 28, Issue:2

    Topics: Aggression; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Female; Humans; Male

1992
Successful treatment of episodic dyscontrol with carbamazepine.
    The British journal of psychiatry : the journal of mental science, 1992, Volume: 161

    Topics: Adolescent; Aggression; Brain Damage, Chronic; Carbamazepine; Dose-Response Relationship, Drug; Head

1992
Paranoid and aggressive behavior in two obsessive-compulsive adolescents treated with clomipramine.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1991, Volume: 30, Issue:6

    Topics: Adolescent; Aggression; Carbamazepine; Child; Clomipramine; Dose-Response Relationship, Drug; Fluoxe

1991
Applying a DRO schedule and compliance training to reduce aggressive and self-injurious behavior in an autistic man: a case report.
    Journal of behavior therapy and experimental psychiatry, 1991, Volume: 22, Issue:4

    Topics: Adult; Aggression; Autistic Disorder; Behavior Therapy; Carbamazepine; Combined Modality Therapy; Ha

1991
Violence in Alzheimer's disease.
    The British journal of psychiatry : the journal of mental science, 1990, Volume: 157

    Topics: Aged; Aggression; Alzheimer Disease; Carbamazepine; Electroencephalography; Humans; Violence

1990
Carbamazepine for aggressive agitation in demented patients during nursing care.
    The American journal of psychiatry, 1989, Volume: 146, Issue:6

    Topics: Aged; Aggression; Alzheimer Disease; Carbamazepine; Female; Humans; Male; Psychomotor Agitation

1989
Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice.
    The International journal of neuroscience, 1988, Volume: 42, Issue:1-2

    Topics: Adenosine; Aggression; Animals; Behavior, Animal; Caffeine; Carbamazepine; Clonidine; Haloperidol; M

1988
Managing behavior in mentally retarded residential populations.
    Hospital & community psychiatry, 1986, Volume: 37, Issue:3

    Topics: Adrenergic beta-Antagonists; Aggression; Antipsychotic Agents; Carbamazepine; Humans; Institutionali

1986
Pharmacotherapy of the aggressive adult patient.
    International journal of law and psychiatry, 1988, Volume: 11, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Aggression; Carbamazepine; Dangerous Behavior; Humans; Lithium;

1988
Combined carbamazepine and lithium therapy for violent behavior.
    The American journal of psychiatry, 1986, Volume: 143, Issue:11

    Topics: Adult; Aggression; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Humans; Intellectual Di

1986
Carbamazepine regulates feline aggression elicited from the midbrain periaqueductal gray.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:2

    Topics: Aggression; Agonistic Behavior; Animals; Carbamazepine; Cats; Electric Stimulation; Female; Male; Pe

1988
Mania and neuropsychiatric excitation following carbamazepine.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1988, Volume: 27, Issue:4

    Topics: Adolescent; Aggression; Akathisia, Drug-Induced; Attention Deficit Disorder with Hyperactivity; Bipo

1988
A preliminary study of carbamazepine in the treatment of assaultive patients with dementia.
    Journal of geriatric psychiatry and neurology, 1988, Volume: 1, Issue:1

    Topics: Aged; Aggression; Carbamazepine; Dementia; Dose-Response Relationship, Drug; Drug Administration Sch

1988
Massive carbamazepine overdose: clinical and pharmacologic observations in five episodes.
    Neurology, 1988, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Aggression; Ataxia; Carbamazepine; Chorea; Coma; Female; Hallucinations; Humans;

1988
Carbamazepine use in assaultive patients.
    Psychosomatics, 1988,Summer, Volume: 29, Issue:3

    Topics: Aggression; Carbamazepine; Humans; Neurocognitive Disorders; Pilot Projects

1988
Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:10

    Topics: Adult; Aggression; Carbamazepine; Disruptive, Impulse Control, and Conduct Disorders; Female; Humans

1987
[Effect of lithium, carbamazepine, ca-valproate and diazepam on changes in social isolation-induced behavior in mice].
    Biomedica biochimica acta, 1985, Volume: 44, Issue:10

    Topics: Aggression; Animals; Behavior, Animal; Carbamazepine; Diazepam; Lithium; Male; Mice; Motor Activity;

1985
Metoprolol for intermittent explosive disorder.
    The American journal of psychiatry, 1985, Volume: 142, Issue:9

    Topics: Adult; Aggression; Anger; Carbamazepine; Humans; Male; Metoprolol; Neurocognitive Disorders; Propran

1985
Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
    Japanese journal of pharmacology, 1985, Volume: 39, Issue:2

    Topics: Aggression; Animals; Bicuculline; Carbamazepine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Ha

1985
[Clinical expressions of aggressive behavior and their treatment].
    Giornale di psichiatria e di neuropatologia, 1968, Volume: 96, Issue:3

    Topics: Aggression; Carbamazepine; Dibenzazepines; Humans; Mental Disorders; Nitriles; Phenothiazines; Piper

1968
[Treatment of character disorders and subcritical epilepsy in adolescents].
    Revue de neuropsychiatrie infantile et d'hygiene mentale de l'enfance, 1973, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aggression; Carbamazepine; Epilepsy; Female; Humans; Male; Mental Disorders; Soci

1973