Page last updated: 2024-10-16

carbamates and Uremia

carbamates has been researched along with Uremia in 18 studies

Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

Research Excerpts

ExcerptRelevanceReference
" Scatchard plots for sulfadiazine binding in plasma from patients with uremia and in normal plasma carbamylated in vitro with potassium cyanate showed changes in the 2 groups when compared with those in normal individuals."3.66Plasma protein carbamylation and decreased acidic drug protein binding in uremia. ( Calvo, R; Carlos, R; Erill, S, 1980)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19906 (33.33)18.7374
1990's5 (27.78)18.2507
2000's3 (16.67)29.6817
2010's3 (16.67)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Yu, ML1
Huang, CF1
Wei, YJ1
Lin, WY1
Lin, YH1
Hsu, PY1
Hsu, CT1
Liu, TW1
Lee, JJ1
Niu, SW1
Huang, JC1
Hung, TS1
Yeh, ML1
Huang, CI1
Liang, PC1
Hsieh, MY1
Chen, SC1
Huang, JF1
Chang, JM1
Chiu, YW1
Dai, CY1
Hwang, SJ1
Chuang, WL1
Pietrement, C1
Gorisse, L1
Jaisson, S1
Gillery, P1
Kalim, S1
Karumanchi, SA1
Thadhani, RI1
Berg, AH1
Schreier, SM1
Hollaus, M1
Hermann, M1
Jirovetz, L1
Exner, M1
Kapiotis, S1
Gmeiner, BM1
Laggner, H1
Wang, Z1
Nicholls, SJ1
Rodriguez, ER1
Kummu, O1
Hörkkö, S1
Barnard, J1
Reynolds, WF1
Topol, EJ1
DiDonato, JA1
Hazen, SL1
Tesio, F1
Cecchin, E1
De Marchi, S1
Quaia, P1
Clegg, LS1
Lindup, WE1
Flückiger, R1
Harmon, W1
Meier, W1
Loo, S1
Gabbay, KH1
Harding, JJ1
Rixon, KC1
Erill, S2
Calvo, R1
Carlos, R1
Frazao, JM1
Barth, RH1
Berlyne, GM2
Davenport, A1
Jones, S1
Goel, S1
Astley, JP1
Feest, TG1
Kraus, LM1
Kraus, AP1
Hasuike, Y1
Nakanishi, T1
Maeda, K1
Tanaka, T1
Inoue, T1
Takamitsu, Y1
Dengler, TJ1
Robertz-Vaupel, GM1
Dengler, HJ1
Bezek, S1
Scasnár, V1
Kukan, M1
Trnovec, T1
du Souich, P1
Courteau, H1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Micro-elimination of Hepatitis C Virus Infection With Pan-genotypic DAA Regimen in Hepatitis C Highly Endemic and Contagious Community (ERASE-C)[NCT03891550]Phase 3135 participants (Anticipated)Interventional2019-05-13Active, not recruiting
Comprehensive Surveillance of HCV Infecion in Uremics Under Maintenance Hemodialysis and Linking to Medical Care in Taiwan[NCT03803410]2,973 participants (Actual)Observational2019-01-07Completed
Clinical Follow-up of Anti-Carbamylated Antibody Status in Rheumatoid Arthritis Patients at 6, 12 and 18 Months[NCT02958319]278 participants (Actual)Observational2016-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

DAS28-ESR

"To explore the clinical differences in activity indexes (DAS28-ESR) at 6, 12 and 18 months of follow-up according the anti-CarP status.~The DAS28 is a composite score derived from 4 measures, one of them can be the erythrocyte sedimentation rate (ESR). We will be using the DAS28-ESR version. To calculate the DAS28-ESR the rheumatologist or specialist nurse will:- count the number of swollen joints (out of the 28), count the number of tender joints (out of the 28), take blood to measure ESR, ask participants to make a 'global assessment of health' (indicated by marking a 10 cm line between very good and very bad).~DAS28-ESR is calculated with classic calculators and resulting values are interpreted as follows:~<2.6: disease remission 2.6 - 3.2: low disease activity 3.2 - 5.1: moderate disease activity >5.1: high disease activity" (NCT02958319)
Timeframe: 6, 12 and 18 Months

,
Interventionunits on a scale (Mean)
6 MONTHS12 MONTHS18 MONTHS
Anti P Carb Negative RA Patients3.753.593.65
Anti P Carb Positive RA Patients3.723.693.77

Reviews

3 reviews available for carbamates and Uremia

ArticleYear
Protein carbamylation in kidney disease: pathogenesis and clinical implications.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014, Volume: 64, Issue:5

    Topics: Animals; Biomarkers; Carbamates; Humans; Kidney Failure, Chronic; Male; Middle Aged; Protein Process

2014
Carbamylated proteins and peptides in health and in uremia.
    Nephron, 1998, Volume: 79, Issue:2

    Topics: Carbamates; Hemoglobin A; Humans; Lipid Metabolism; Peptides; Renal Dialysis; Uremia

1998
Carbamoylation of amino acids and proteins in uremia.
    Kidney international. Supplement, 2001, Volume: 78

    Topics: Amino Acids; Animals; Carbamates; Cyanates; Diabetic Nephropathies; Enzymes; Glucose; Hormones; Huma

2001

Trials

1 trial available for carbamates and Uremia

ArticleYear
Carbamylated hemoglobin: a potential marker for the adequacy of hemodialysis therapy in end-stage renal failure.
    Kidney international, 1996, Volume: 50, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Carbamates; Diabetes Mellitus;

1996

Other Studies

14 other studies available for carbamates and Uremia

ArticleYear
Establishment of an outreach, grouping healthcare system to achieve microelimination of HCV for uremic patients in haemodialysis centres (ERASE-C).
    Gut, 2021, Volume: 70, Issue:12

    Topics: Antiviral Agents; Carbamates; Drug Combinations; Hemodialysis Units, Hospital; Hepatitis C; Heterocy

2021
Establishment of an outreach, grouping healthcare system to achieve microelimination of HCV for uremic patients in haemodialysis centres (ERASE-C).
    Gut, 2021, Volume: 70, Issue:12

    Topics: Antiviral Agents; Carbamates; Drug Combinations; Hemodialysis Units, Hospital; Hepatitis C; Heterocy

2021
Establishment of an outreach, grouping healthcare system to achieve microelimination of HCV for uremic patients in haemodialysis centres (ERASE-C).
    Gut, 2021, Volume: 70, Issue:12

    Topics: Antiviral Agents; Carbamates; Drug Combinations; Hemodialysis Units, Hospital; Hepatitis C; Heterocy

2021
Establishment of an outreach, grouping healthcare system to achieve microelimination of HCV for uremic patients in haemodialysis centres (ERASE-C).
    Gut, 2021, Volume: 70, Issue:12

    Topics: Antiviral Agents; Carbamates; Drug Combinations; Hemodialysis Units, Hospital; Hepatitis C; Heterocy

2021
Chronic increase of urea leads to carbamylated proteins accumulation in tissues in a mouse model of CKD.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Carbamates; Collagen; Disease Models, Animal; Extracellular Matrix; Female; Kinetics; Mice;

2013
Carbamoylated free amino acids in uremia: HOCl generates volatile protein modifying and cytotoxic oxidant species from N-carbamoyl-threonine but not threonine.
    Biochimie, 2012, Volume: 94, Issue:11

    Topics: Aldehydes; Carbamates; Cell Line; Cytotoxins; Humans; Hypochlorous Acid; Lipoproteins, LDL; Oxidants

2012
Protein carbamylation links inflammation, smoking, uremia and atherogenesis.
    Nature medicine, 2007, Volume: 13, Issue:10

    Topics: Animals; Atherosclerosis; Blood Proteins; Carbamates; Cholesterol; Citrulline; Clinical Trials as To

2007
Glycosylated or carbamylated hemoglobin in uremia?
    The New England journal of medicine, 1982, Apr-29, Volume: 306, Issue:17

    Topics: Carbamates; Glucose Tolerance Test; Glycated Hemoglobin; Hemoglobin A; Humans; Renal Dialysis; Uremi

1982
Drug binding defect of uraemic plasma: unlikely involvement of carbamoylated albumin.
    Biochemical pharmacology, 1982, Sep-01, Volume: 31, Issue:17

    Topics: Animals; Azo Compounds; Carbamates; Cattle; Humans; Pharmaceutical Preparations; Protein Binding; Sa

1982
Hemoglobin carbamylation in uremia.
    The New England journal of medicine, 1981, Apr-02, Volume: 304, Issue:14

    Topics: Adolescent; Adult; Aged; Carbamates; Child; Child, Preschool; Chromatography, Gas; Cyanates; Hemoglo

1981
Is diarrhoea a major cause of cataract in some tropical countries?
    Metabolic and pediatric ophthalmology, 1981, Volume: 5, Issue:3-4

    Topics: Acidosis; Animals; Carbamates; Cataract; Cattle; Dehydration; Diarrhea; Eye Proteins; Humans; In Vit

1981
Plasma protein carbamylation and decreased acidic drug protein binding in uremia.
    Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:5

    Topics: Adult; Binding Sites; Binding, Competitive; Blood Proteins; Carbamates; Charcoal; Cyanates; Female;

1980
Carbamylated hemoglobin in prerenal azotemia.
    Nephron, 1995, Volume: 71, Issue:2

    Topics: Aged; Aged, 80 and over; Blood Urea Nitrogen; Carbamates; Creatinine; Diagnosis, Differential; Femal

1995
Carbamylated hemoglobin as a therapeutic marker in hemodialysis.
    Nephron, 2002, Volume: 91, Issue:2

    Topics: Biomarkers; Blood Urea Nitrogen; Carbamates; Female; Hemoglobins; Humans; Kidney Failure, Chronic; M

2002
Albumin binding in uraemia: quantitative assessment of inhibition by endogenous ligands and carbamylation of albumin.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:5

    Topics: Amino Acid Sequence; Binding, Competitive; Carbamates; Dansyl Compounds; Fluorescent Dyes; Glycine;

1992
Kinetics of biliary elimination of pentacaine in rats.
    Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:5

    Topics: Animals; Bile; Bile Ducts; Brain; Carbamates; Feces; Injections, Intravenous; Liver; Male; Rats; Rat

1990
Carbamylation of proteins and sulfacetamide free fraction in serum in experimentally-induced high blood urea states.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 50, Issue:1

    Topics: Animals; Blood Proteins; Blood Urea Nitrogen; Carbamates; Creatinine; Kidney Failure, Chronic; Male;

1985