carbamates has been researched along with Polycythemia Vera in 6 studies
Polycythemia Vera: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this multicentre, open-label, phase II study, 44 patients with polycythaemia vera (PV), unresponsive to the maximum tolerated doses (MTD) of hydroxycarbamide (HC), were treated with Givinostat (50 or 100 mg/d) in combination with MTD of HC." | 2.78 | A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy. ( Barbui, T; Barosi, G; Cilloni, D; Demuth, T; Finazzi, G; Finazzi, MC; Fioritoni, G; Martinelli, V; Musolino, C; Nobile, F; Olimpieri, OM; Pogliani, EM; Rambaldi, A; Ruggeri, M; Sivera, P; Specchia, G; Tollo, SD; Vannucchi, AM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rambaldi, A | 4 |
| Iurlo, A | 2 |
| Vannucchi, AM | 3 |
| Noble, R | 1 |
| von Bubnoff, N | 2 |
| Guarini, A | 2 |
| Martino, B | 2 |
| Pezzutto, A | 1 |
| Carli, G | 1 |
| De Muro, M | 2 |
| Luciani, S | 2 |
| McMullin, MF | 2 |
| Cambier, N | 1 |
| Marolleau, JP | 1 |
| Mesa, RA | 1 |
| Tibes, R | 1 |
| Pancrazzi, A | 1 |
| Gesullo, F | 1 |
| Bettica, P | 2 |
| Manzoni, S | 2 |
| Di Tollo, S | 2 |
| Chifotides, HT | 1 |
| Bose, P | 1 |
| Verstovsek, S | 1 |
| Ruggeri, M | 2 |
| Martinelli, V | 2 |
| Nogai, A | 1 |
| Rosti, V | 1 |
| Ricco, A | 1 |
| Finazzi, G | 2 |
| Nobile, F | 1 |
| Specchia, G | 1 |
| Pogliani, EM | 1 |
| Olimpieri, OM | 1 |
| Fioritoni, G | 1 |
| Musolino, C | 1 |
| Cilloni, D | 1 |
| Sivera, P | 1 |
| Barosi, G | 1 |
| Finazzi, MC | 1 |
| Tollo, SD | 1 |
| Demuth, T | 1 |
| Barbui, T | 1 |
| Yoshimoto, G | 1 |
| Miyamoto, T | 1 |
| Amaru Calzada, A | 1 |
| Pedrini, O | 1 |
| Leoni, F | 1 |
| Mascagni, P | 1 |
| Introna, M | 1 |
| Golay, J | 1 |
2 reviews available for carbamates and Polycythemia Vera
| Article | Year |
|---|---|
Givinostat: an emerging treatment for polycythemia vera.
Topics: Animals; Carbamates; Disease Progression; Histone Deacetylase Inhibitors; Humans; Hydroxyurea; Janus | 2020 |
[Treatment strategy for myeloproliferative neoplasms].
Topics: Adrenal Cortex Hormones; Aspirin; Calreticulin; Carbamates; Clinical Trials as Topic; Drug Therapy, | 2014 |
3 trials available for carbamates and Polycythemia Vera
| Article | Year |
|---|---|
Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Female; Humans; Janus Kinase 2; Male; Maximum Tolerated | 2020 |
Long-term safety and efficacy of givinostat in polycythemia vera: 4-year mean follow up of three phase 1/2 studies and a compassionate use program.
Topics: Adult; Aged; Carbamates; Female; Follow-Up Studies; Histone Deacetylase Inhibitors; Humans; Male; Mi | 2021 |
A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Dose-Response Relationship, Drug; Drug Administration Sc | 2013 |
1 other study available for carbamates and Polycythemia Vera
| Article | Year |
|---|---|
Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients.
Topics: Amino Acid Substitution; Antineoplastic Agents; Apoptosis; Blotting, Western; Carbamates; Caspase 3; | 2013 |