carbamates has been researched along with Leukemia P388 in 23 studies
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of 12 semisynthetic discodermolide analogues, 2-13, have been prepared using natural (+)-discodermolide (1) and evaluated for in vitro cytotoxicity against cultured murine P-388 leukemia and A-549 human adenocarcinoma cells." | 3.71 | Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity. ( Gunasekera, SP; Isbrucker, RA; Longley, RE, 2002) |
| "Etoposide (VP-16) is a potent human DNA topoisomerase II poison, derived from 4'-demethylepipodophyllotoxin, widely used in cancer chemotherapy." | 1.33 | Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives. ( Arimondo, PB; Bertounesque, E; Dauzonne, D; Duca, M; Guianvarc'h, D; Kraus-Berthier, L; Léonce, S; Meresse, P; Monneret, C; Pfeiffer, B; Pierré, A; Renard, P; Thirot, S, 2005) |
| " Pharmacokinetic studies in rats demonstrated that oral absorption of FB642 was variable and may be saturated at the 2000 mg/kg dose level since higher doses failed to produce a further increase in the area under the time concentration curve." | 1.31 | Preclinical antitumor activity and pharmacokinetics of methyl-2-benzimidazolecarbamate (FB642). ( Camden, JB; Dexter, DL; Hao, D; Mangold, GL; Marty, J; Moore, RV; Rizzo, JD; Stringer, S; Von Hoff, DD; Weitman, SD, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (47.83) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, D | 1 |
| Rizzo, JD | 1 |
| Stringer, S | 1 |
| Moore, RV | 1 |
| Marty, J | 1 |
| Dexter, DL | 1 |
| Mangold, GL | 1 |
| Camden, JB | 1 |
| Von Hoff, DD | 1 |
| Weitman, SD | 1 |
| Gunasekera, SP | 3 |
| Longley, RE | 2 |
| Isbrucker, RA | 2 |
| Mickel, SJ | 1 |
| Daeffler, R | 1 |
| Niederer, D | 1 |
| Wright, AE | 1 |
| Linley, P | 1 |
| Pitts, T | 1 |
| Duca, M | 1 |
| Guianvarc'h, D | 1 |
| Meresse, P | 1 |
| Bertounesque, E | 1 |
| Dauzonne, D | 1 |
| Kraus-Berthier, L | 1 |
| Thirot, S | 1 |
| Léonce, S | 1 |
| Pierré, A | 1 |
| Pfeiffer, B | 1 |
| Renard, P | 1 |
| Arimondo, PB | 1 |
| Monneret, C | 1 |
| Anderson, WK | 9 |
| McPherson, HL | 2 |
| New, JS | 1 |
| Rick, AC | 2 |
| Mulumba, B | 1 |
| Jones, AN | 1 |
| Chang, CP | 1 |
| Halat, MJ | 2 |
| Denyer, CV | 1 |
| Reddy, MT | 1 |
| Jenkins, DC | 1 |
| Rapson, E | 1 |
| Watts, SD | 1 |
| Kamigiri, K | 1 |
| Suzuki, Y | 1 |
| Shibazaki, M | 1 |
| Morioka, M | 1 |
| Suzuki, K | 1 |
| Tokunaga, T | 1 |
| Setiawan, B | 1 |
| Rantiatmodjo, RM | 1 |
| Unno, R | 1 |
| Michishita, H | 1 |
| Inagaki, H | 1 |
| Baba, Y | 1 |
| Jomori, T | 1 |
| Nishikawa, T | 1 |
| Isobe, M | 1 |
| Atwell, GJ | 1 |
| Fan, JY | 1 |
| Tan, K | 1 |
| Denny, WA | 1 |
| Shindo, N | 1 |
| Fujimura, T | 1 |
| Nojima-Kazuno, S | 1 |
| Mineki, R | 1 |
| Furusawa, S | 1 |
| Sasaki, K | 1 |
| Murayama, K | 1 |
| Andreani, A | 1 |
| Rambaldi, M | 1 |
| Locatelli, A | 1 |
| Fraccari, A | 1 |
| Bossa, R | 1 |
| Galatulas, I | 1 |
| Temple, C | 2 |
| Rener, GA | 2 |
| Comber, RN | 2 |
| Waud, WR | 1 |
| Heider, AR | 1 |
| Raju, N | 1 |
| Yucht, JA | 1 |
| Mach, RH | 1 |
| Milowsky, AS | 1 |
| Nasr, M | 1 |
| Paull, KD | 1 |
| Narayanan, VL | 1 |
23 other studies available for carbamates and Leukemia P388
| Article | Year |
|---|---|
Preclinical antitumor activity and pharmacokinetics of methyl-2-benzimidazolecarbamate (FB642).
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzimidazoles; Carbamates; Cell Division; Cell Su | 2002 |
Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.
Topics: Adenocarcinoma; Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Screening Assays, Antitumo | 2002 |
Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.
Topics: Alkanes; Animals; Antineoplastic Agents; Carbamates; Drug Screening Assays, Antitumor; Humans; Lacto | 2004 |
Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.
Topics: Animals; Antineoplastic Agents; Carbamates; Cell Line, Tumor; Drug Screening Assays, Antitumor; Huma | 2005 |
Synthesis and murine antineoplastic activity of bis[(carbamoyloxy)methyl] derivatives of pyrrolo[2,1-a]isoquinoline.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carbamates; Chemical Phenomena; Chemistry; Isoquin | 1984 |
Synthesis of Methyl 2,3-bis(hydroxymethyl)-5-phenyl-7-oxabicyclo[2.2.1]hepta-2,5-diene- 6-carboxylate bis(N-methylcarbamate) derivatives as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Carbamates; Chemi | 1984 |
Synthesis and evaluation of furan, thiophene, and azole bis[(carbamoyloxy)methyl] derivatives as potential antineoplastic agents.
Topics: Animals; Antineoplastic Agents; Carbamates; Chemical Phenomena; Chemistry; Drug Evaluation, Preclini | 1984 |
Synthesis, evaluation of chemical reactivity, and murine antineoplastic activity of 2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H- pyrrolizine bis(2-propylcarbamate) and 2-acyloxy derivatives as potential water-soluble prodrugs.
Topics: Animals; Antineoplastic Agents; Carbamates; Chromatography, High Pressure Liquid; Dosage Forms; Leuk | 1983 |
Synthesis and antileukemic activity of 1-methyl-2,5-diphenyl-3,4-bis(hydroxymethyl)-, 1,2,3-triphenyl-4,5-bis(hydroxymethyl)-, and 1-methyl-2,3-diphenyl-4,5-bis(hydroxymethyl)pyrrole bis(N-methylcarbamate).
Topics: Animals; Antineoplastic Agents; Carbamates; Female; Leukemia P388; Male; Mice; Structure-Activity Re | 1980 |
Synthesis of antitumour carbon-bridged imidazopyridazine carbamates.
Topics: Animals; Antineoplastic Agents; Carbamates; Cell Division; Horses; Imidazoles; Leukemia P388; Mice; | 1994 |
Kalimantacins A, B and C, novel antibiotics from Alcaligenes sp. YL-02632S. I. Taxonomy, fermentation, isolation and biological properties.
Topics: Alcaligenes; Animals; Anti-Bacterial Agents; Carbamates; Fatty Acids, Unsaturated; HeLa Cells; Human | 1996 |
Synthesis and biological evaluation of novel cyclic enediyne compounds related to dynemicin A as antitumor agents.
Topics: Alkynes; Animals; Anthraquinones; Antibiotics, Antineoplastic; Bridged Bicyclo Compounds; Carbamates | 1997 |
DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.
Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Carbamates; Cross-Linking Rea | 1998 |
Identification of multidrug resistant protein 1 of mouse leukemia P388 cells on a PVDF membrane using 6-aminoquinolyl-carbamyl (AQC)-amino acid analysis and World Wide Web (WWW)-accessible tools.
Topics: Amino Acids; Aminoquinolines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cali | 1998 |
Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.
Topics: Acetylation; Alkanes; Animals; Antineoplastic Agents; Carbamates; Lactones; Leukemia P388; Magnetic | 2001 |
Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate).
Topics: Animals; Antineoplastic Agents; Bacteria; Carbamates; Chemical Phenomena; Chemistry; Leukemia P388; | 1979 |
Potential antitumor agents XIX [1]. Synthesis and antitumor activity of tricyclic compounds related to lotifazole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carbamates; Carcinoma, Ehrl | 1992 |
Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates.
Topics: Animals; Antineoplastic Agents; Carbamates; Leukemia L1210; Leukemia P388; Mice; Pyrazines; Structur | 1991 |
New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)car bamates.
Topics: Animals; Antineoplastic Agents; Carbamates; Cell Survival; Indicators and Reagents; Leukemia L1210; | 1989 |
Synthesis and antileukemic activity of bis[[(carbamoyl)oxy]methyl]- substituted pyrrolo[2,1-a]isoquinolines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isobenzazepines, and pyrrolo[1,2-a]benzazepines.
Topics: Animals; Antineoplastic Agents; Benzazepines; Carbamates; Isoquinolines; Leukemia P388; Leukemia, Ex | 1988 |
Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6,7-bis(hydroxymethyl)pyrrolo[1,2-c]thiazole biscarbamates and the corresponding sulfoxides and sulfones.
Topics: Animals; Antineoplastic Agents; Carbamates; Leukemia P388; Leukemia, Experimental; Mice; Structure-A | 1987 |
Synthesis and antineoplastic activity of bis[[[(alkylamino)carbonyl]oxy]methyl]-substituted 3-pyrrolines as prodrugs of tumor inhibitory pyrrole bis(carbamates).
Topics: Animals; Antineoplastic Agents; Carbamates; Leukemia P388; Pyrroles; Structure-Activity Relationship | 1986 |
Computer-assisted structure--anticancer activity correlations of carbamates and thiocarbamates.
Topics: Animals; Antineoplastic Agents; Carbamates; Computers; Leukemia L1210; Leukemia P388; Mice; Models, | 1985 |