Page last updated: 2024-10-16

carbamates and Drug Refractory Epilepsy

carbamates has been researched along with Drug Refractory Epilepsy in 12 studies

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to evaluate the efficacy and safety of adjunctive retigabine/ezogabine (RTG/EZG) therapy in Asian adults with partial-onset seizures."9.22Efficacy and safety of retigabine/ezogabine as adjunctive therapy in adult Asian patients with drug-resistant partial-onset seizures: A randomized, placebo-controlled Phase III study. ( Kwan, P; Lim, KS; Lotay, N; White, R, 2016)
"Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice."5.48Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018)
"The purpose of this study was to evaluate the efficacy and safety of adjunctive retigabine/ezogabine (RTG/EZG) therapy in Asian adults with partial-onset seizures."5.22Efficacy and safety of retigabine/ezogabine as adjunctive therapy in adult Asian patients with drug-resistant partial-onset seizures: A randomized, placebo-controlled Phase III study. ( Kwan, P; Lim, KS; Lotay, N; White, R, 2016)
"Management of drug resistant epilepsy (DRE) represents a challenge to the treating clinician."3.01Cenobamate in refractory epilepsy: Overview of treatment options and practical considerations. ( Ben-Menachem, E; Kälviäinen, R; Lattanzi, S; Nashef, L; Schmitz, B; Vonck, K, 2023)
" We calculated the risk ratio (RR) of ≥50%, ≥75% and 100% reduction in seizure frequency from baseline, as well as dropout and serious adverse events related to treatment."2.72Efficacy and safety of cenobamate in patients with uncontrolled focal seizures: A meta-analysis. ( Wang, C; Wang, J; Zhang, L, 2021)
"We measured seizure reduction, median reduction in seizure frequency, median dose, responder rate, and treatment-emergent adverse events."1.72Adjunctive use of cenobamate for pediatric refractory focal-onset epilepsy: A single-center retrospective study. ( Karkare, S; Kothare, SV; Shah, YD; Varughese, RT, 2022)
"Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice."1.48Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018)
"Retigabine reduced seizure frequency or severity for 24."1.43Adjunctive retigabine in refractory focal epilepsy: Postmarketing experience at four tertiary epilepsy care centers in Germany. ( Elger, CE; Graf, W; Hamer, HM; Kasper, B; Kull, A; Kurth, C; Nass, RD; Rosenow, F; Steinhoff, BJ; Strzelczyk, A; Surges, R, 2016)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (41.67)24.3611
2020's7 (58.33)2.80

Authors

AuthorsStudies
Lu, C1
Zheng, J1
Cao, Y1
Bresnahan, R1
Martin-McGill, KJ1
Varughese, RT1
Shah, YD1
Karkare, S1
Kothare, SV1
Rissardo, JP1
Fornari Caprara, AL1
Makridis, KL1
Kaindl, AM1
Schmitz, B1
Lattanzi, S1
Vonck, K1
Kälviäinen, R1
Nashef, L1
Ben-Menachem, E1
Wheless, JW1
Zhang, L1
Wang, J1
Wang, C1
Terrone, G1
Pauletti, A1
Salamone, A1
Rizzi, M1
Villa, BR1
Porcu, L1
Sheehan, MJ1
Guilmette, E1
Butler, CR1
Piro, JR1
Samad, TA1
Vezzani, A1
Vanhoof-Villalba, SL1
Gautier, NM1
Mishra, V1
Glasscock, E1
Brodie, MJ1
Nass, RD1
Kurth, C1
Kull, A1
Graf, W1
Kasper, B1
Hamer, HM1
Strzelczyk, A1
Elger, CE1
Steinhoff, BJ1
Surges, R1
Rosenow, F1
Lim, KS1
Lotay, N1
White, R1
Kwan, P1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Carisbamate as Adjunctive Therapy in Subjects With Partial Onset Seizures.[NCT00740623]Phase 3547 participants (Actual)Interventional2009-01-31Completed
[NCT00228969]Phase 20 participants Interventional2005-02-28Completed
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of RWJ-333369 as Adjunctive Therapy in Subjects With Partial Onset Seizures Followed by an Open-Label Extension Study.[NCT00425282]Phase 3566 participants (Actual)Interventional2006-11-30Completed
Epilepsy Phase III Trial[NCT00433667]Phase 3563 participants (Actual)Interventional2006-11-30Completed
Clinical Validation Study of the Simplified Seizure Classification Algorithm[NCT03796520]240 participants (Actual)Observational2019-06-02Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for carbamates and Drug Refractory Epilepsy

ArticleYear
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Carisbamate add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2021, 12-06, Volume: 12

    Topics: Adult; Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies,

2021
Cenobamate (YKP3089) and Drug-Resistant Epilepsy: A Review of the Literature.
    Medicina (Kaunas, Lithuania), 2023, Jul-28, Volume: 59, Issue:8

    Topics: Animals; Carbamates; Chlorophenols; Drug Resistant Epilepsy; Seizures; Tetrazoles; United States

2023
Real-world experience with cenobamate: A systematic review and meta-analysis.
    Seizure, 2023, Volume: 112

    Topics: Adult; Anticonvulsants; Carbamates; Child; Drug Resistant Epilepsy; Epilepsies, Partial; Humans; Sei

2023
Cenobamate in refractory epilepsy: Overview of treatment options and practical considerations.
    Epilepsia open, 2023, Volume: 8, Issue:4

    Topics: Anticonvulsants; Carbamates; Drug Resistant Epilepsy; Epilepsies, Partial; Humans; Tetrazoles

2023
Adjunctive cenobamate for the treatment of focal onset seizures in adults with epilepsy: a critical review.
    Expert review of neurotherapeutics, 2020, Volume: 20, Issue:11

    Topics: Adult; Animals; Anticonvulsants; Carbamates; Chlorophenols; Drug Resistant Epilepsy; Humans; Tetrazo

2020
Efficacy and safety of cenobamate in patients with uncontrolled focal seizures: A meta-analysis.
    Acta neurologica Scandinavica, 2021, Volume: 144, Issue:1

    Topics: Anticonvulsants; Carbamates; Chlorophenols; Dizziness; Dose-Response Relationship, Drug; Drug Resist

2021
Practical Use of Newer Antiepileptic Drugs as Adjunctive Therapy in Focal Epilepsy.
    CNS drugs, 2015, Volume: 29, Issue:11

    Topics: Acetamides; Adult; Aged; Animals; Anticonvulsants; Carbamates; Dibenzazepines; Drug Resistant Epilep

2015

Trials

1 trial available for carbamates and Drug Refractory Epilepsy

ArticleYear
Efficacy and safety of retigabine/ezogabine as adjunctive therapy in adult Asian patients with drug-resistant partial-onset seizures: A randomized, placebo-controlled Phase III study.
    Epilepsy & behavior : E&B, 2016, Volume: 61

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Double-Blind Method; Drug Resistant Epilepsy;

2016

Other Studies

4 other studies available for carbamates and Drug Refractory Epilepsy

ArticleYear
Adjunctive use of cenobamate for pediatric refractory focal-onset epilepsy: A single-center retrospective study.
    Epilepsy & behavior : E&B, 2022, Volume: 130

    Topics: Adolescent; Adult; Anticonvulsants; Carbamates; Child; Chlorophenols; Drug Resistant Epilepsy; Epile

2022
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
    Epilepsia, 2018, Volume: 59, Issue:1

    Topics: Animals; Brain; Brain Waves; Carbamates; Cognition Disorders; Diazepam; Disease Models, Animal; Dose

2018
Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy.
    Epilepsia, 2018, Volume: 59, Issue:2

    Topics: Animals; Anticonvulsants; Atrioventricular Block; Behavior, Animal; Bradycardia; Carbamates; Channel

2018
Adjunctive retigabine in refractory focal epilepsy: Postmarketing experience at four tertiary epilepsy care centers in Germany.
    Epilepsy & behavior : E&B, 2016, Volume: 56

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Child; Death, Sudden, Cardiac; Drug Resistant

2016