carbamates has been researched along with Cytokine Release Syndrome in 1 studies
Cytokine Release Syndrome: A severe immune reaction characterized by excessive release of CYTOKINES. Symptoms include DYSPNEA; FEVER; HEADACHE; HYPOTENSION; NAUSEA; RASH; TACHYCARDIA; HYPOXIA; HYPERFERRITINEMIA, and MULTIPLE ORGAN FAILURE. It is associated with viral infections, SEPSIS; AUTOIMMUNE DISEASES and a variety of factors used in IMMUNOTHERAPY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme of the de novo pyrimidine nucleotide biosynthesis pathway." | 1.62 | The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines. ( Bavari, S; Cao, L; Cintron-Lue, K; Colacino, JM; Goodwin, E; Graci, JD; Jacobson, A; Kong, R; Luban, J; Mühlberger, E; Naryshkin, NA; O'Keefe, K; Paessler, S; Peltz, SW; Pykett, M; Sattler, RA; Soloveva, V; Strambio-De-Castillia, C; Suder, EL; Trotta, C; Wang, Y; Weetall, M; Welch, EM, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luban, J | 1 |
| Sattler, RA | 1 |
| Mühlberger, E | 1 |
| Graci, JD | 1 |
| Cao, L | 1 |
| Weetall, M | 1 |
| Trotta, C | 1 |
| Colacino, JM | 1 |
| Bavari, S | 1 |
| Strambio-De-Castillia, C | 1 |
| Suder, EL | 1 |
| Wang, Y | 1 |
| Soloveva, V | 1 |
| Cintron-Lue, K | 1 |
| Naryshkin, NA | 1 |
| Pykett, M | 1 |
| Welch, EM | 1 |
| O'Keefe, K | 1 |
| Kong, R | 1 |
| Goodwin, E | 1 |
| Jacobson, A | 1 |
| Paessler, S | 1 |
| Peltz, SW | 1 |
1 other study available for carbamates and Cytokine Release Syndrome
| Article | Year |
|---|---|
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.
Topics: Animals; Antiviral Agents; Carbamates; Carbazoles; Chlorocebus aethiops; COVID-19 Drug Treatment; Cy | 2021 |