Page last updated: 2024-10-16

carbamates and Atherogenesis

carbamates has been researched along with Atherogenesis in 11 studies

Research Excerpts

ExcerptRelevanceReference
"EXPANDING OUR KNOWLEDGE: Natural lipocyclocarbamate natural products have provided the inspiration for the first-in-class synthetic phospholipase inhibitor darapladib, currently in phase III clinical trials for the treatment of atherosclerosis."3.79Nonribosomal assembly of natural lipocyclocarbamate lipoprotein-associated phospholipase inhibitors. ( Johnston, CW; Khyzha, N; Magarvey, NA; Zvanych, R, 2013)
"Experimental diabetes mellitus was produced by a single intraperitoneal injection of STZ (55mg/kg b."1.43Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar rats. ( Berredjem, H; Berredjem, M; Bouzerna, N; Cheloufi, H; Réggami, Y, 2016)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Spinelli, FR1
Pecani, A1
Ciciarello, F1
Colasanti, T1
Di Franco, M1
Miranda, F1
Conti, F1
Valesini, G1
Alessandri, C1
Apostolov, EO1
Ok, E1
Burns, S1
Nawaz, S1
Savenka, A1
Shah, S1
Basnakian, AG1
Ketelhuth, DF1
Hermansson, A1
Hlawaty, H1
Letourneur, D1
Yan, ZQ2
Bäck, M2
Réggami, Y1
Berredjem, H1
Cheloufi, H1
Berredjem, M1
Bouzerna, N1
Lenglet, S1
Thomas, A1
Soehnlein, O1
Montecucco, F1
Burger, F1
Pelli, G1
Galan, K1
Cravatt, B1
Staub, C1
Steffens, S1
Johnston, CW1
Zvanych, R1
Khyzha, N1
Magarvey, NA1
Kodvawala, A1
Ghering, AB1
Davidson, WS1
Hui, DY1
Bu, DX1
Bränström, R1
Sheikine, Y1
Hansson, GK1
Allred, KF1
Smart, EJ1
Wilson, ME1
Wang, Z1
Nicholls, SJ1
Rodriguez, ER1
Kummu, O1
Hörkkö, S1
Barnard, J1
Reynolds, WF1
Topol, EJ1
DiDonato, JA1
Hazen, SL1
Rader, DJ1
Ischiropoulos, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Follow-up of Anti-Carbamylated Antibody Status in Rheumatoid Arthritis Patients at 6, 12 and 18 Months[NCT02958319]278 participants (Actual)Observational2016-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

DAS28-ESR

"To explore the clinical differences in activity indexes (DAS28-ESR) at 6, 12 and 18 months of follow-up according the anti-CarP status.~The DAS28 is a composite score derived from 4 measures, one of them can be the erythrocyte sedimentation rate (ESR). We will be using the DAS28-ESR version. To calculate the DAS28-ESR the rheumatologist or specialist nurse will:- count the number of swollen joints (out of the 28), count the number of tender joints (out of the 28), take blood to measure ESR, ask participants to make a 'global assessment of health' (indicated by marking a 10 cm line between very good and very bad).~DAS28-ESR is calculated with classic calculators and resulting values are interpreted as follows:~<2.6: disease remission 2.6 - 3.2: low disease activity 3.2 - 5.1: moderate disease activity >5.1: high disease activity" (NCT02958319)
Timeframe: 6, 12 and 18 Months

,
Interventionunits on a scale (Mean)
6 MONTHS12 MONTHS18 MONTHS
Anti P Carb Negative RA Patients3.753.593.65
Anti P Carb Positive RA Patients3.723.693.77

Other Studies

11 other studies available for carbamates and Atherogenesis

ArticleYear
Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients.
    BMC musculoskeletal disorders, 2017, 05-25, Volume: 18, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Atherosclerosis; Autoantibodies; Blood Proteins; Carbamates; Car

2017
Carbamylated-oxidized LDL: proatherosclerotic effects on endothelial cells and macrophages.
    Journal of atherosclerosis and thrombosis, 2013, Volume: 20, Issue:12

    Topics: Atherosclerosis; Carbamates; Cell Death; Cells, Cultured; Endothelium, Vascular; Enzyme-Linked Immun

2013
The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE-/- mice.
    Prostaglandins & other lipid mediators, 2015, Volume: 121, Issue:Pt A

    Topics: Amidines; Animals; Apolipoproteins E; Atherosclerosis; Carbamates; Cytokines; Male; Matrix Metallopr

2015
Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar rats.
    European journal of pharmacology, 2016, May-15, Volume: 779

    Topics: Animals; Atherosclerosis; Bilirubin; Blood Glucose; Body Weight; Carbamates; Creatinine; Diabetes Me

2016
Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:2

    Topics: Amides; Amidohydrolases; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Arachidonic Acids; Athe

2013
Nonribosomal assembly of natural lipocyclocarbamate lipoprotein-associated phospholipase inhibitors.
    Chembiochem : a European journal of chemical biology, 2013, Mar-04, Volume: 14, Issue:4

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Atherosclerosis; Benzaldehydes; Biological Products;

2013
Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis.
    The Journal of biological chemistry, 2005, Nov-18, Volume: 280, Issue:46

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Biological Transport; Carbamates; Carboxylesterase; Cer

2005
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Nov-29, Volume: 102, Issue:48

    Topics: Amidines; Analysis of Variance; Animals; Atherosclerosis; Blotting, Western; Carbamates; Carotid Art

2005
Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors.
    The Journal of biological chemistry, 2006, Jan-20, Volume: 281, Issue:3

    Topics: Animals; Atherosclerosis; Carbamates; Cholesterol; Estrogen Receptor alpha; Female; Furans; HIV Prot

2006
Protein carbamylation links inflammation, smoking, uremia and atherogenesis.
    Nature medicine, 2007, Volume: 13, Issue:10

    Topics: Animals; Atherosclerosis; Blood Proteins; Carbamates; Cholesterol; Citrulline; Clinical Trials as To

2007
'Multipurpose oxidase' in atherogenesis.
    Nature medicine, 2007, Volume: 13, Issue:10

    Topics: Animals; Apoptosis; Atherosclerosis; Carbamates; Cardiovascular Diseases; Cell Proliferation; Citrul

2007