carbachol has been researched along with Urinary Incontinence in 19 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Urinary Incontinence: Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types of incontinence include URINARY URGE INCONTINENCE and URINARY STRESS INCONTINENCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths." | 3.65 | Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor. ( Foley, DJ; McPhillips, JJ, 1973) |
| "To create an animal model for neurogenic underactive bladder disease (UAB) and identify markers to describe secondary myogenic changes in the bladder wall." | 1.48 | Characterization of voiding function and structural bladder changes in a rat model of neurogenic underactive bladder disease. ( Albersen, M; Bivalacqua, TJ; De Ridder, D; Deruyer, Y; Dewulf, K; Everaerts, W; Rietjens, R; Van der Aa, F; Weyne, E, 2018) |
| "Acquired urinary incontinence is a significant, incurable problem, prevalent in neutered bitches but rarely seen in entire bitches or males." | 1.35 | Neutering affects urinary bladder function by different mechanisms in male and female dogs. ( Coit, VA; Dowell, FJ; Evans, NP; Gibson, IF, 2008) |
| " Concurrently the effect of nortriptyline low dosage therapy was studied in 21 women suffering from motor or sensory urgency and urge incontinence." | 1.27 | Selective effect of nortriptyline on smooth muscle as an anticholinergic drug: a pharmacological and clinical study. ( Cohen, S; Katz, A; Nissenkorn, I; Rubinstein, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Callewaert, G | 1 |
| Monteiro Carvalho Mori Da Cunha, MG | 1 |
| Dewulf, K | 2 |
| Albersen, M | 2 |
| Deprest, J | 1 |
| Weyne, E | 1 |
| Deruyer, Y | 1 |
| Rietjens, R | 1 |
| Everaerts, W | 2 |
| Bivalacqua, TJ | 1 |
| De Ridder, D | 2 |
| Van der Aa, F | 1 |
| Gevaert, T | 1 |
| Owsianik, G | 1 |
| Hutchings, G | 1 |
| Van Leuven, L | 1 |
| Nilius, B | 1 |
| Braverman, AS | 1 |
| Tallarida, RJ | 1 |
| Ruggieri, MR | 1 |
| Lluel, P | 1 |
| Deplanne, V | 1 |
| Heudes, D | 1 |
| Bruneval, P | 1 |
| Palea, S | 1 |
| Christ, GJ | 1 |
| Day, NS | 1 |
| Day, M | 1 |
| Zhao, W | 1 |
| Persson, K | 1 |
| Pandita, RK | 1 |
| Andersson, KE | 2 |
| Wang, F | 1 |
| Jackson, MW | 1 |
| Maughan, V | 1 |
| Cavill, D | 1 |
| Smith, AJ | 1 |
| Waterman, SA | 1 |
| Gordon, TP | 1 |
| Wai, CY | 1 |
| Liehr, P | 1 |
| Boreham, MK | 1 |
| Schaffer, JI | 1 |
| Word, RA | 1 |
| Stevens, LA | 1 |
| Sellers, DJ | 1 |
| McKay, NG | 1 |
| Chapple, CR | 1 |
| Chess-Williams, R | 1 |
| Coit, VA | 1 |
| Gibson, IF | 1 |
| Evans, NP | 1 |
| Dowell, FJ | 1 |
| Melchior, H | 1 |
| Rud, T | 1 |
| Boye, N | 1 |
| Ulmsten, U | 1 |
| Werkstrom, V | 1 |
| Lam, DS | 1 |
| Farnsworth, RH | 1 |
| Awad, N | 1 |
| Burcher, E | 1 |
| Moore, KH | 1 |
| Hewawasam, P | 1 |
| Erway, M | 1 |
| Thalody, G | 1 |
| Weiner, H | 1 |
| Boissard, CG | 1 |
| Gribkoff, VK | 1 |
| Meanwell, NA | 1 |
| Lodge, N | 1 |
| Starrett, JE | 1 |
| Carter, JP | 1 |
| Noronha-Blob, L | 2 |
| Audia, VH | 1 |
| Dupont, AC | 1 |
| McPherson, DW | 1 |
| Natalie, KJ | 1 |
| Rzeszotarski, WJ | 1 |
| Spagnuolo, CJ | 1 |
| Waid, PP | 1 |
| Kaiser, C | 1 |
| Peterson, JS | 1 |
| Patton, AJ | 1 |
| Nissenkorn, I | 1 |
| Katz, A | 1 |
| Rubinstein, R | 1 |
| Cohen, S | 1 |
| Nergårdh, A | 1 |
| von Hedenberg, C | 1 |
| Hellström, B | 1 |
| Ericsson, NO | 1 |
| Foley, DJ | 1 |
| McPhillips, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Oral Boldo in Improving Urinary Symptoms and Body Stability in Women Diagnosed With Overactive Bladder[NCT06162065] | Phase 1 | 10 participants (Anticipated) | Interventional | 2023-11-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for carbachol and Urinary Incontinence
| Article | Year |
|---|---|
Simulated vaginal delivery causes transients vaginal smooth muscle hypersensitivity and urethral sphincter dysfunction.
Topics: Animals; Carbachol; Cholinergic Agonists; Delivery, Obstetric; Female; Models, Animal; Muscle Contra | 2020 |
Characterization of voiding function and structural bladder changes in a rat model of neurogenic underactive bladder disease.
Topics: Animals; Carbachol; Gene Expression; Male; Muscarinic Agonists; Muscle Contraction; Myocytes, Smooth | 2018 |
The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity.
Topics: Animals; Carbachol; Disease Models, Animal; Female; In Vitro Techniques; Muscarinic Agonists; Muscle | 2009 |
Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction.
Topics: Animals; Carbachol; Cholinergic Agents; Denervation; Female; In Vitro Techniques; Muscarinic Antagon | 2002 |
Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability?
Topics: Adrenergic Agents; Aging; Animals; Carbachol; Male; Muscle Contraction; Muscle, Smooth; Phenylephrin | 2003 |
Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo.
Topics: Animals; Carbachol; Cell Communication; Connexin 43; Disease Models, Animal; Female; Gap Junctions; | 2003 |
Passive transfer of Sjogren's syndrome IgG produces the pathophysiology of overactive bladder.
Topics: Animals; Autoantibodies; Carbachol; Electric Stimulation; Humans; Immunoglobulin G; In Vitro Techniq | 2004 |
Effect of periurethral denervation on smooth muscles of the lower urinary tract.
Topics: Animals; Biopsy, Needle; Carbachol; Disease Models, Animal; Female; Immunohistochemistry; Muscle Con | 2004 |
Muscarinic receptor function, density and G-protein coupling in the overactive diabetic rat bladder.
Topics: Animals; Binding, Competitive; Carbachol; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2006 |
Neutering affects urinary bladder function by different mechanisms in male and female dogs.
Topics: Animals; Carbachol; Collagen; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Electric Stimula | 2008 |
[Drug therapy of detrusor dysfunction].
Topics: Adult; Aged; Carbachol; Dinoprost; Female; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Sm | 1983 |
Terodiline inhibition of human bladder contraction. Effects in vitro and in women with unstable bladder.
Topics: Adolescent; Adult; Aged; Butylamines; Carbachol; Child; Child, Preschool; Dose-Response Relationship | 1980 |
In vitro contractile responses of detrusor to carbachol and neurokinin A, in children with recurrent urinary tract infection or day wetting.
Topics: Adolescent; Carbachol; Child; Child, Preschool; Cholinergic Agonists; Female; Humans; Infant; Male; | 2000 |
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.
Topics: Animals; Azo Compounds; Calcium; Carbachol; Cells, Cultured; Electrophysiology; Humans; Large-Conduc | 2002 |
Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds.
Topics: Alkynes; Amines; Animals; Carbachol; Cyclobutanes; Female; Guinea Pigs; Mandelic Acids; Muscarinic A | 1991 |
Mini-pig urinary bladder function: comparisons of in vitro anticholinergic responses and in vivo cystometry with drugs indicated for urinary incontinence.
Topics: Animals; Carbachol; Female; Guinea Pigs; Muscle Contraction; Parasympatholytics; Swine; Swine, Minia | 1990 |
Selective effect of nortriptyline on smooth muscle as an anticholinergic drug: a pharmacological and clinical study.
Topics: Bethanechol Compounds; Carbachol; Dose-Response Relationship, Drug; Female; Humans; Ileum; Muscle Co | 1986 |
Continence training of children with neurogenic bladder dysfunction.
Topics: Adolescent; Adult; Age Factors; Carbachol; Child; Child, Preschool; Constipation; Diazepam; Ephedrin | 1974 |
Response of the rat ileum, uterus and vas deferens to carbachol and acetylcholine following repeated daily administration of a cholinesterase inhibitor.
Topics: Acetylcholine; Animals; Carbachol; Cholinesterases; Diarrhea; Disulfoton; Drug Interactions; Female; | 1973 |