carbachol has been researched along with Urinary Bladder, Overactive in 44 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Urinary Bladder, Overactive: Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirabegron is used for treatment of storage symptoms in overactive bladder (OAB) caused by spontaneous bladder smooth muscle contractions." | 8.12 | Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions. ( Hennenberg, M; Huang, R; Stief, CG; Strittmatter, F; Tamalunas, A; Waidelich, R, 2022) |
| "The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH)." | 7.81 | The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia. ( Fuse, M; Kaga, K; Kamai, T; Shibata, C; Uchiyama, T; Yamanishi, T, 2015) |
| "Ascorbic acid and citric acid augmented bladder muscle contraction possibly by enhanced Ca(2+) influx." | 7.75 | Modification of rat detrusor muscle contraction by ascorbic acid and citric acid involving enhanced neurotransmitter release and Ca2+ influx. ( Dasgupta, J; Elliott, RA; Tincello, DG, 2009) |
| "To investigate the effects of menthol, an activator of the temperature-sensitive transient receptor potential family member TRPM8, on detrusor smooth-muscle contraction and the micturition reflex in rats." | 7.74 | Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats. ( Harada, K; Ikeda, S; Kamikawa, Y; Kawahira, K; Nomoto, Y; Ohwatashi, A; Yoshida, A, 2008) |
| "Mirabegron is used for treatment of storage symptoms in overactive bladder (OAB) caused by spontaneous bladder smooth muscle contractions." | 4.12 | Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions. ( Hennenberg, M; Huang, R; Stief, CG; Strittmatter, F; Tamalunas, A; Waidelich, R, 2022) |
| "To evaluate the effects of the beta-3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity." | 3.85 | Long-term treatment with the beta-3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice. ( Alexandre, EC; Antunes, E; Calmasini, FB; Candido, TZ; da Silva, CPV; da Silva, FH; de Oliveira, MG; Mónica, FZ, 2017) |
| "The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH)." | 3.81 | The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia. ( Fuse, M; Kaga, K; Kamai, T; Shibata, C; Uchiyama, T; Yamanishi, T, 2015) |
| " Metformin treatment improved the insulin sensitivity, and normalized the in vitro bladder hypercontractility and cystometric dysfunction in obese mice." | 3.78 | Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice. ( Anhê, GF; Antunes, E; Calixto, MC; De Nucci, G; Grant, AD; Leiria, LO; Lintomen, L; Mónica, FZ; Sollon, C; Zanesco, A, 2012) |
| "Ascorbic acid and citric acid augmented bladder muscle contraction possibly by enhanced Ca(2+) influx." | 3.75 | Modification of rat detrusor muscle contraction by ascorbic acid and citric acid involving enhanced neurotransmitter release and Ca2+ influx. ( Dasgupta, J; Elliott, RA; Tincello, DG, 2009) |
| "To investigate the effects of menthol, an activator of the temperature-sensitive transient receptor potential family member TRPM8, on detrusor smooth-muscle contraction and the micturition reflex in rats." | 3.74 | Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats. ( Harada, K; Ikeda, S; Kamikawa, Y; Kawahira, K; Nomoto, Y; Ohwatashi, A; Yoshida, A, 2008) |
| " Furthermore, the effects of eviprostat on carbachol-induced muscle contraction were evaluated by an in vitro experiment." | 3.74 | Effect of eviprostat on bladder overactivity in an experimental cystitis rat model. ( Fujimoto, N; Kobayashi, M; Matsumoto, S; Matsumoto, T; Nishii, H; Nomura, M, 2008) |
| "Model rats underwent bladder outlet obstruction surgery." | 1.91 | Excitatory purinergic and cholinergic expression changed in a partial bladder outlet obstruction-induced overactive bladder rat model. ( Cao, H; Huang, J; Li, H; Liu, J; Long, Y; Zhang, Y, 2023) |
| "Mice treated with mirabegron or solifenacin displayed significantly fewer voiding events compared to the stressed mice, and voiding frequency in drug-treated animals was comparable to unstressed controls." | 1.72 | Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice. ( Chess-Williams, R; McDermott, C; Sellers, DJ; West, EG, 2022) |
| "These symptoms are similar to the overactive bladder syndrome." | 1.40 | Izalpinin from fruits of Alpinia oxyphylla with antagonistic activity against the rat bladder contractility. ( Chen, F; Chen, WY; Huang, GJ; Li, H; Li, YH; Tan, YF; Xu, P; Yuan, Y; Zhang, JQ, 2014) |
| "To evaluate chronic hyperlipidemia on bladder function, we examined the functional and histological changes of the bladder in myocardial infarction-prone Watanabe Heritable Hyperlipidemic (WHHLMI) rabbits." | 1.36 | The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits. ( Masunaga, K; Nagata, T; Satoji, Y; Shiomi, M; Yoshida, M, 2010) |
| "Organ hypertrophy is often found to be associated with changes in the expression of caveolins and altered density of caveolae in the membrane." | 1.36 | Biochemical and functional correlates of an increased membrane density of caveolae in hypertrophic rat urinary bladder. ( Ekman, M; Shakirova, Y; Swärd, K; Uvelius, B, 2010) |
| "L-carnitine treatment restored the hyporesponsiveness of isoprenaline and the hyperresponsiveness of adenosine-elicited relaxation." | 1.35 | L-carnitine treatment partially restores urinary bladder function of streptozotocin diabetic rats. ( Gur, S; Irat, AM, 2008) |
| "Overactive bladder is a complex and widely prevalent condition, but little is known about its physiopathology." | 1.35 | Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity. ( Abdalla, FM; Antunes, E; Báu, FR; Bricola, AA; De Nucci, G; Freitas, LL; Mónica, FZ; Muscará, MN; Porto, CS; Teixeira, SA; Zanesco, A, 2008) |
| "Partial bladder outlet obstruction (PBOO) is believed to change the functions of the detrusor, and can lead to an overactive detrusor (OD)." | 1.33 | Effect of partial bladder outlet obstruction on detrusor compliance, excitability and contractility in rats. ( Hao, P; Li, L; Qiu, G; Song, B, 2006) |
| " Validation showed that carbachol produced a dose-response curve closely mirroring that observed in the isolated muscle strips and demonstrated the dual nature of electrically evoked neurotransmission, consisting of a cholinergic component largely mediated by M(3) receptors and a purinergic component mediated by P2X receptors." | 1.33 | The use of the isolated mouse whole bladder for investigating bladder overactivity. ( Brading, AF; Fabiyi, AC, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (34.09) | 29.6817 |
| 2010's | 24 (54.55) | 24.3611 |
| 2020's | 5 (11.36) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, R | 1 |
| Tamalunas, A | 1 |
| Waidelich, R | 1 |
| Strittmatter, F | 1 |
| Stief, CG | 1 |
| Hennenberg, M | 1 |
| West, EG | 2 |
| McDermott, C | 2 |
| Chess-Williams, R | 3 |
| Sellers, DJ | 2 |
| Huang, J | 1 |
| Li, H | 2 |
| Zhang, Y | 1 |
| Liu, J | 1 |
| Cao, H | 1 |
| Long, Y | 1 |
| Mizutani, H | 1 |
| Sakakibara, F | 1 |
| Sasaki, E | 1 |
| Klee, NS | 1 |
| Moreland, RS | 1 |
| Kendig, DM | 1 |
| Babaoglu, M | 1 |
| Zumrutbas, AE | 1 |
| Acar, IC | 1 |
| Hatip, FB | 1 |
| Kucukatay, V | 1 |
| Eskicorapci, S | 1 |
| Aybek, Z | 1 |
| Michel, MC | 2 |
| La Fuente, JM | 1 |
| Fernández, A | 1 |
| Cuevas, P | 1 |
| González-Corrochano, R | 1 |
| Chen, MX | 1 |
| Angulo, J | 1 |
| Yuan, Y | 1 |
| Tan, YF | 1 |
| Xu, P | 1 |
| Li, YH | 1 |
| Chen, WY | 1 |
| Zhang, JQ | 1 |
| Chen, F | 1 |
| Huang, GJ | 1 |
| Yamanishi, T | 1 |
| Kaga, K | 1 |
| Fuse, M | 1 |
| Shibata, C | 1 |
| Kamai, T | 1 |
| Uchiyama, T | 1 |
| Xin, W | 1 |
| Li, N | 1 |
| Fernandes, VS | 1 |
| Chen, B | 1 |
| Rovner, ES | 2 |
| Petkov, GV | 2 |
| Zhai, K | 1 |
| Yang, Z | 1 |
| Zhu, X | 1 |
| Nyirimigabo, E | 1 |
| Mi, Y | 1 |
| Wang, Y | 1 |
| Liu, Q | 1 |
| Man, L | 1 |
| Wu, S | 1 |
| Jin, J | 1 |
| Ji, G | 1 |
| Zhou, X | 1 |
| Lam, WP | 1 |
| Tang, HC | 1 |
| Koon, CM | 1 |
| Cheng, L | 1 |
| Lau, CB | 1 |
| Liang, W | 1 |
| Leung, PC | 1 |
| Calmasini, FB | 1 |
| de Oliveira, MG | 1 |
| Alexandre, EC | 1 |
| da Silva, FH | 1 |
| da Silva, CPV | 1 |
| Candido, TZ | 1 |
| Antunes, E | 3 |
| Mónica, FZ | 3 |
| Gevaert, T | 1 |
| Owsianik, G | 1 |
| Hutchings, G | 1 |
| Van Leuven, L | 1 |
| Everaerts, W | 1 |
| Nilius, B | 1 |
| De Ridder, D | 1 |
| Gur, S | 1 |
| Irat, AM | 1 |
| Dasgupta, J | 1 |
| Elliott, RA | 1 |
| Tincello, DG | 1 |
| Sand, C | 1 |
| Yoshida, M | 1 |
| Masunaga, K | 1 |
| Nagata, T | 1 |
| Satoji, Y | 1 |
| Shiomi, M | 1 |
| Kita, M | 2 |
| Yunoki, T | 2 |
| Takimoto, K | 1 |
| Miyazato, M | 1 |
| Kita, K | 1 |
| de Groat, WC | 2 |
| Kakizaki, H | 1 |
| Yoshimura, N | 2 |
| Sinha, S | 1 |
| Gupta, S | 1 |
| Malhotra, S | 1 |
| Krishna, NS | 1 |
| Meru, AV | 1 |
| Babu, V | 1 |
| Bansal, V | 1 |
| Garg, M | 1 |
| Kumar, N | 1 |
| Chugh, A | 1 |
| Ray, A | 1 |
| Shakirova, Y | 1 |
| Swärd, K | 1 |
| Uvelius, B | 1 |
| Ekman, M | 1 |
| Russo, A | 1 |
| Castiglione, F | 1 |
| Salonia, A | 1 |
| Benigni, F | 1 |
| Rigatti, P | 1 |
| Montorsi, F | 1 |
| Andersson, KE | 2 |
| Hedlund, P | 1 |
| Andrade, EL | 1 |
| Forner, S | 1 |
| Bento, AF | 1 |
| Leite, DF | 1 |
| Dias, MA | 1 |
| Leal, PC | 1 |
| Koepp, J | 1 |
| Calixto, JB | 1 |
| Asfaw, TS | 1 |
| Hypolite, J | 1 |
| Northington, GM | 1 |
| Arya, LA | 1 |
| Wein, AJ | 1 |
| Malykhina, AP | 1 |
| Owen, SJ | 1 |
| Rose'Meyer, RB | 1 |
| Massa, HM | 1 |
| Eser, N | 1 |
| Göçmen, C | 1 |
| Erdoğan, S | 1 |
| Büyüknacar, HS | 1 |
| Kumcu, EK | 1 |
| Açıkalın, A | 1 |
| Önder, S | 1 |
| Schuler, V | 1 |
| Suter, K | 1 |
| Fürer, K | 1 |
| Eberli, D | 1 |
| Horst, M | 1 |
| Betschart, C | 1 |
| Brenneisen, R | 1 |
| Hamburger, M | 1 |
| Mennet, M | 1 |
| Schnelle, M | 1 |
| Simões-Wüst, AP | 1 |
| von Mandach, U | 1 |
| Leiria, LO | 1 |
| Sollon, C | 1 |
| Calixto, MC | 1 |
| Lintomen, L | 1 |
| Anhê, GF | 1 |
| De Nucci, G | 2 |
| Zanesco, A | 2 |
| Grant, AD | 1 |
| Valeri, A | 1 |
| Capasso, R | 1 |
| Valoti, M | 1 |
| Pessina, F | 1 |
| Soder, RP | 1 |
| Parajuli, SP | 1 |
| Hristov, KL | 1 |
| Svalø, J | 1 |
| Nordling, J | 1 |
| Bouchelouche, K | 1 |
| Korstanje, C | 1 |
| Bouchelouche, P | 1 |
| Li, L | 1 |
| Qiu, G | 1 |
| Hao, P | 1 |
| Song, B | 1 |
| Fabiyi, AC | 1 |
| Brading, AF | 1 |
| Stevens, LA | 1 |
| Chapple, CR | 1 |
| Ohtake, A | 1 |
| Saitoh, C | 1 |
| Yuyama, H | 1 |
| Ukai, M | 1 |
| Okutsu, H | 1 |
| Noguchi, Y | 1 |
| Hatanaka, T | 1 |
| Suzuki, M | 1 |
| Sato, S | 1 |
| Sasamata, M | 1 |
| Miyata, K | 1 |
| Lai, HH | 1 |
| Boone, TB | 1 |
| Thompson, TC | 1 |
| Smith, CP | 1 |
| Somogyi, GT | 1 |
| Zhu, HL | 1 |
| Iwasa, K | 1 |
| Tomoda, T | 1 |
| Aishima, M | 1 |
| Shibata, A | 1 |
| Naito, S | 1 |
| Teramoto, N | 1 |
| Bricola, AA | 1 |
| Báu, FR | 1 |
| Freitas, LL | 1 |
| Teixeira, SA | 1 |
| Muscará, MN | 1 |
| Abdalla, FM | 1 |
| Porto, CS | 1 |
| Nomoto, Y | 1 |
| Yoshida, A | 1 |
| Ikeda, S | 1 |
| Kamikawa, Y | 1 |
| Harada, K | 1 |
| Ohwatashi, A | 1 |
| Kawahira, K | 1 |
| Furuta, A | 1 |
| Suzuki, Y | 1 |
| Egawa, S | 1 |
| Chancellor, MB | 1 |
| Kobayashi, M | 1 |
| Nomura, M | 1 |
| Nishii, H | 1 |
| Matsumoto, S | 1 |
| Fujimoto, N | 1 |
| Matsumoto, T | 1 |
| Uno, T | 1 |
| Kobayashi, F | 1 |
| Ogata, A | 1 |
| Konomi, T | 1 |
1 review available for carbachol and Urinary Bladder, Overactive
| Article | Year |
|---|---|
[Pharmacological and clinical profile of imidafenacin developed as a new therapeutic agent for overactive bladder].
Topics: Acetylcholine; Animals; Carbachol; Clinical Trials as Topic; Drug-Related Side Effects and Adverse R | 2008 |
43 other studies available for carbachol and Urinary Bladder, Overactive
| Article | Year |
|---|---|
Inhibition of Full Smooth Muscle Contraction in Isolated Human Detrusor Tissues by Mirabegron Is Limited to Off-Target Inhibition of Neurogenic Contractions.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetanilides; Carbachol; Endothe | 2022 |
Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice.
Topics: Acetanilides; Animals; Carbachol; Female; Mice; Muscarinic Antagonists; Solifenacin Succinate; Stres | 2022 |
Excitatory purinergic and cholinergic expression changed in a partial bladder outlet obstruction-induced overactive bladder rat model.
Topics: Animals; Carbachol; Cholinergic Agents; Female; Humans; Rats; Urinary Bladder; Urinary Bladder Neck | 2023 |
TAS-303 Ameliorates Carbachol-Induced Detrusor Overactivity in Rats, Revealing Its Therapeutic Potential for Overactive Bladder.
Topics: Adrenergic beta-3 Receptor Antagonists; Animals; Atropine; Carbachol; Dose-Response Relationship, Dr | 2020 |
Bladder overactivity induced by psychological stress in female mice is associated with enhanced bladder contractility.
Topics: Acetylcholine; Animals; Carbachol; Corticosterone; Female; Mice; Mice, Inbred C57BL; Muscarinic Agon | 2021 |
Detrusor contractility to parasympathetic mediators is differentially altered in the compensated and decompensated states of diabetic bladder dysfunction.
Topics: Adenosine Triphosphate; Animals; Carbachol; Cholinergic Agonists; Diabetes Mellitus, Experimental; D | 2019 |
Gap junction expression and the effects of gap junction inhibitors in overactive bladder models: does ovariectomy have a role?
Topics: Analysis of Variance; Animals; Blotting, Western; Carbachol; Connexin 43; Disease Models, Animal; Fe | 2013 |
Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder?
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; | 2014 |
Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats.
Topics: Acetic Acid; Adult; Aged; Animals; Carbachol; Electric Stimulation; Female; Humans; Large-Conductanc | 2014 |
Izalpinin from fruits of Alpinia oxyphylla with antagonistic activity against the rat bladder contractility.
Topics: Alpinia; Carbachol; Cholinergic Agonists; Flavonoids; Fruit; Muscarinic Antagonists; Muscle Contract | 2014 |
The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia.
Topics: Carbachol; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Muscarinic Agonists; | 2015 |
BK channel regulation by phosphodiesterase type 1: a novel signaling pathway controlling human detrusor smooth muscle function.
Topics: Aged; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Drug Evaluation, Preclinical | 2016 |
Activation of bitter taste receptors (tas2rs) relaxes detrusor smooth muscle and suppresses overactive bladder symptoms.
Topics: Aged; Animals; Antirheumatic Agents; Carbachol; Cardiotonic Agents; Chloroquine; Female; Humans; Mal | 2016 |
Effects of Gegen (Puerariae lobatae Radix) water extract on improving detrusor overactivity in spontaneously hypertensive rats.
Topics: Animals; Benzofurans; Carbachol; China; Drugs, Chinese Herbal; Male; Muscle Contraction; Muscle, Smo | 2016 |
Long-term treatment with the beta-3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Body Weight; Carbachol; Cyclic AMP; Cycl | 2017 |
The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity.
Topics: Animals; Carbachol; Disease Models, Animal; Female; In Vitro Techniques; Muscarinic Agonists; Muscle | 2009 |
L-carnitine treatment partially restores urinary bladder function of streptozotocin diabetic rats.
Topics: Adenosine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Autonomic Nervous System; Bloo | 2008 |
Modification of rat detrusor muscle contraction by ascorbic acid and citric acid involving enhanced neurotransmitter release and Ca2+ influx.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Ascorbic Acid; Atropine; Calcium Signaling; Carbachol | 2009 |
Effect of pre-contraction on β-adrenoceptor-mediated relaxation of rat urinary bladder.
Topics: Adrenergic beta-Agonists; Animals; Bradykinin; Carbachol; Colforsin; Dose-Response Relationship, Dru | 2009 |
The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits.
Topics: Animals; Atherosclerosis; Calcitonin Gene-Related Peptide; Carbachol; Cholinergic Agonists; Chronic | 2010 |
Effects of bladder outlet obstruction on properties of Ca2+-activated K+ channels in rat bladder.
Topics: Animals; Apamin; Carbachol; Charybdotoxin; Cholinergic Agonists; Female; Large-Conductance Calcium-A | 2010 |
AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line, Transformed; CHO Cell | 2010 |
Biochemical and functional correlates of an increased membrane density of caveolae in hypertrophic rat urinary bladder.
Topics: Animals; Bradykinin; Carbachol; Caveolae; Caveolin 1; Cell Membrane; Female; Hypertrophy; In Vitro T | 2010 |
Effects of the gonadotropin-releasing hormone antagonist ganirelix on normal micturition and prostaglandin E(2)-induced detrusor overactivity in conscious female rats.
Topics: Administration, Intravesical; Animals; Blotting, Western; Carbachol; Cholinergic Agonists; Conscious | 2011 |
TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury.
Topics: Acetanilides; Acrolein; Animals; Ankyrins; Calcium Channels; Capsaicin; Carbachol; Disease Models, A | 2011 |
Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization.
Topics: Acute Disease; Animals; Carbachol; Cholinergic Agents; Colitis; Diterpenes; Electric Stimulation; Ma | 2011 |
Dietary phytoestrogens maintain contractile responses to carbachol with age in the female rat isolated bladder.
Topics: Age Factors; Animal Feed; Animals; Body Weight; Carbachol; Cholinergic Agonists; Female; Glycine max | 2011 |
Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model.
Topics: Animals; Carbachol; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; Muscle Contraction; | 2012 |
Bryophyllum pinnatum inhibits detrusor contractility in porcine bladder strips--a pharmacological study towards a new treatment option of overactive bladder.
Topics: Animals; Carbachol; Cholinergic Agonists; Electric Stimulation; Kalanchoe; Mandelic Acids; Muscarini | 2012 |
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
Topics: Adiposity; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Cal | 2012 |
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder.
Topics: Animals; Anthracenes; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulati | 2012 |
SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle.
Topics: Adult; Aged; Apamin; Benzothiazoles; Carbachol; Electric Stimulation; Female; Humans; Male; Membrane | 2013 |
The novel β3-adrenoceptor agonist mirabegron reduces carbachol-induced contractile activity in detrusor tissue from patients with bladder outflow obstruction with or without detrusor overactivity.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Aged; Aged, 80 and over | 2013 |
Effect of partial bladder outlet obstruction on detrusor compliance, excitability and contractility in rats.
Topics: Animals; Carbachol; Compliance; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; | 2006 |
The use of the isolated mouse whole bladder for investigating bladder overactivity.
Topics: Adenosine Triphosphate; Anesthetics, Local; Animals; Atropine; Bradykinin; Carbachol; Dose-Response | 2006 |
Human idiopathic and neurogenic overactive bladders and the role of M2 muscarinic receptors in contraction.
Topics: Adult; Aged; Benzofurans; Carbachol; Diamines; Dose-Response Relationship, Drug; Female; Humans; In | 2007 |
Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Benzofurans; Binding, Competitive; Carbachol; C | 2007 |
Using caveolin-1 knockout mouse to study impaired detrusor contractility and disrupted muscarinic activity in the aging bladder.
Topics: Aging; Animals; Carbachol; Caveolin 1; Disease Models, Animal; Electric Stimulation; Male; Mice; Mic | 2007 |
Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles.
Topics: Animals; Aorta; Carbachol; Dihydropyridines; Electrophysiology; Guinea Pigs; Isometric Contraction; | 2008 |
Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Animals; Carbachol; Inositol Phosphat | 2008 |
Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats.
Topics: Animals; Antipruritics; Capsaicin; Carbachol; Female; Menthol; Muscle Contraction; Muscle, Smooth; R | 2008 |
Association of overactive bladder and stress urinary incontinence in rats with pudendal nerve ligation injury.
Topics: Adrenergic alpha-Agonists; Animals; Capsaicin; Carbachol; Enzyme-Linked Immunosorbent Assay; Female; | 2008 |
Effect of eviprostat on bladder overactivity in an experimental cystitis rat model.
Topics: Animals; Antineoplastic Agents, Alkylating; Carbachol; Cholinergic Agonists; Cyclophosphamide; Cysti | 2008 |