carbachol has been researched along with Retinal Degeneration in 4 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carbachol treatment of RCS RPE results in an increase in the second messenger inositol triphosphate, which mimics that observed in normal RPE after interaction with rod outer segments (ROS)." | 1.29 | IP3 generation increases rod outer segment phagocytosis by cultured Royal College of Surgeons retinal pigment epithelium. ( Heth, CA; Marescalchi, PA; Ye, L, 1995) |
| "Carbachol treatment of RCS RPE produced an increase in IP3 levels, demonstrating that the components of the IP3 pathway are present and the pathway can be activated." | 1.29 | Inositol triphosphate generation in cultured rat retinal pigment epithelium. ( Heth, CA; Marescalchi, PA, 1994) |
| "Carbachol does not increase OS phagocytosis in normal or RCS rat RPE cells." | 1.29 | Carbachol does not correct the defect in the phagocytosis of outer segments by Royal College of Surgeons rat retinal pigment epithelial cells. ( Abrams, TA; Burgess, BL; Hall, MO; Martinez, MO, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lucas, RJ | 1 |
| Hattar, S | 1 |
| Takao, M | 1 |
| Berson, DM | 1 |
| Foster, RG | 1 |
| Yau, KW | 1 |
| Heth, CA | 2 |
| Marescalchi, PA | 2 |
| Ye, L | 1 |
| Hall, MO | 1 |
| Burgess, BL | 1 |
| Abrams, TA | 1 |
| Martinez, MO | 1 |
4 other studies available for carbachol and Retinal Degeneration
| Article | Year |
|---|---|
Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice.
Topics: Adaptation, Ocular; Animals; Carbachol; Circadian Rhythm; Darkness; Light; Light Signal Transduction | 2003 |
IP3 generation increases rod outer segment phagocytosis by cultured Royal College of Surgeons retinal pigment epithelium.
Topics: Animals; Carbachol; Cells, Cultured; Fluorescent Antibody Technique; Immunohistochemistry; Inositol | 1995 |
Inositol triphosphate generation in cultured rat retinal pigment epithelium.
Topics: Animals; Carbachol; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Laye | 1994 |
Carbachol does not correct the defect in the phagocytosis of outer segments by Royal College of Surgeons rat retinal pigment epithelial cells.
Topics: Animals; Carbachol; Cells, Cultured; Inositol 1,4,5-Trisphosphate; Lithium Chloride; Phagocytosis; P | 1996 |