carbachol has been researched along with Pancreatic Neoplasms in 34 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms." | 3.69 | Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis. ( Hertelendy, ZI; Knittel, JJ; Patel, DG, 1996) |
| "Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells." | 3.67 | Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells. ( Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T, 1987) |
| "Fragments of the nafenopin-induced pancreatic acinar cell carcinoma of rat have been examined in vitro for patterns of intracellular protein transport and carbamylcholine-induced protein discharge." | 3.66 | Transplantable pancreatic acinar carcinoma. ( Reddy, JK; Warren, JR, 1981) |
| "Pancreatic cancer is a lethal malignancy whose progression is highly dependent on the nervous microenvironment." | 1.43 | Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression. ( Cong, L; Hamada, Y; Jiang, X; Lei, Y; Li, J; Li, Y; Wang, N; Zheng, W, 2016) |
| "Human glucagonoma cells were isolated and maintained in vitro." | 1.29 | Acetylcholine regulates glucagon secretion from human glucagonoma cells. ( Funakoshi, A; Ikeda, S; Jimi, A; Ryu, S; Shinozaki, H; Yasunami, Y, 1994) |
| "PANC-1 and MIA PaCa-2 human pancreatic cancer cell lines were grown for four to six days in the presence or absence of JMV-180 (10(-10)-10(-6) M) alone or in combination with carbachol (10 mM)." | 1.29 | Cholecystokinin analog, JMV-180, stimulates growth of human pancreatic cancer. ( Smith, JP; Swift, IR, 1994) |
| "The carbachol-induced increase in cAMP levels was inhibited by atropine." | 1.28 | Interaction between phosphoinositide turnover system and cyclic AMP pathway for the secretion of pancreastatin and somatostatin from QGP-1N cells. ( Funakoshi, A; Kitayama, N; Matsuoka, Y; Tateishi, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (38.24) | 18.7374 |
| 1990's | 20 (58.82) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, Y | 1 |
| Hamada, Y | 1 |
| Li, J | 1 |
| Cong, L | 1 |
| Wang, N | 1 |
| Li, Y | 1 |
| Zheng, W | 1 |
| Jiang, X | 1 |
| Warren, JR | 3 |
| Reddy, JK | 1 |
| Simeone, DM | 1 |
| Yule, DI | 1 |
| Logsdon, CD | 1 |
| Williams, JA | 2 |
| Funakoshi, A | 6 |
| Yasunami, Y | 2 |
| Ryu, S | 2 |
| Shinozaki, H | 2 |
| Jimi, A | 4 |
| Ikeda, S | 2 |
| Tateishi, K | 4 |
| Kitayama, N | 2 |
| Matsuoka, Y | 2 |
| Kono, A | 3 |
| Schmidt, WE | 1 |
| Seebeck, J | 1 |
| Höcker, M | 1 |
| Schwarzhoff, R | 1 |
| Schäfer, H | 1 |
| Fornefeld, H | 1 |
| Morys-Wortmann, C | 1 |
| Fölsch, UR | 1 |
| Creutzfeldt, W | 1 |
| Swift, IR | 1 |
| Smith, JP | 1 |
| Miyazaki, K | 1 |
| Sjöholm, A | 1 |
| Arkhammar, P | 1 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 1 |
| Hertelendy, ZI | 1 |
| Patel, DG | 1 |
| Knittel, JJ | 1 |
| Xu, G | 1 |
| Howland, J | 1 |
| Rothenberg, PL | 1 |
| Montserrat, C | 1 |
| Merten, M | 1 |
| Figarella, C | 1 |
| Konard, RJ | 1 |
| Stoller, JZ | 1 |
| Gao, ZY | 1 |
| Wolf, BA | 1 |
| Deeg, MA | 1 |
| Verchere, CB | 1 |
| Xu, S | 1 |
| Khoo, S | 1 |
| Dang, A | 1 |
| Witt, S | 1 |
| Do, V | 1 |
| Zhen, E | 1 |
| Schaefer, EM | 1 |
| Cobb, MH | 1 |
| Tang, SH | 1 |
| Sharp, GW | 3 |
| Bode, HP | 1 |
| Weber, S | 1 |
| Fehmann, HC | 1 |
| Göke, B | 1 |
| Tsuru, M | 2 |
| Wakasugi, H | 1 |
| D'Ambra, R | 1 |
| Surana, M | 1 |
| Efrat, S | 1 |
| Starr, RG | 1 |
| Fleischer, N | 1 |
| Bastié, MJ | 1 |
| Chiba, T | 2 |
| Yamatani, T | 2 |
| Kadowaki, S | 2 |
| Yamaguchi, A | 2 |
| Inui, T | 2 |
| Saito, Y | 1 |
| Fujita, T | 2 |
| Yada, T | 1 |
| Russo, LL | 1 |
| Taton, G | 1 |
| Delhaye, M | 1 |
| Swillens, S | 1 |
| Morisset, J | 1 |
| Larose, L | 1 |
| Longnecker, DS | 1 |
| Poirier, GG | 1 |
| Ackerman, MS | 1 |
| Roeske, WR | 1 |
| Heck, RJ | 1 |
| Korc, M | 1 |
| Hishikawa, R | 1 |
| Kawazu, S | 1 |
| Prentki, M | 1 |
| Glennon, MC | 1 |
| Thomas, AP | 1 |
| Morris, RL | 1 |
| Matschinsky, FM | 1 |
| Corkey, BE | 1 |
| Elouaer-Blanc, L | 1 |
| Sobhani, I | 1 |
| Ruszniewski, P | 1 |
| Duet, M | 1 |
| Lehy, T | 1 |
| Mignon, M | 1 |
| Bonfils, S | 1 |
| Lewin, MJ | 1 |
| Gylfe, E | 1 |
| Hellman, B | 1 |
| Hoenig, M | 1 |
| Blachier, F | 1 |
| Malaisse, WJ | 1 |
| Chien, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
34 other studies available for carbachol and Pancreatic Neoplasms
| Article | Year |
|---|---|
Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression.
Topics: Animals; Antineoplastic Agents; Atropine; Carbachol; Cell Line, Tumor; Delayed-Action Preparations; | 2016 |
Secretagogue response in rat pancreatic acinar carcinoma.
Topics: Animals; Bucladesine; Calcimycin; Carbachol; Carcinoma; Cell Membrane; Cholecystokinin; Dose-Respons | 1982 |
Transplantable pancreatic acinar carcinoma.
Topics: Animals; Autoradiography; Biological Transport; Carbachol; Carcinoma; Cytoplasmic Granules; Enzyme P | 1981 |
Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Bombesin; Bradykinin; Calcitonin Gene-Related Peptid | 1995 |
Acetylcholine regulates glucagon secretion from human glucagonoma cells.
Topics: Carbachol; Glucagon; Glucagonoma; Humans; Male; Middle Aged; Pancreatic Neoplasms; Pancreatic Polype | 1994 |
Parallel secretion of pancreastatin and somatostatin from human pancreastatin producing cell line (QGP-1N).
Topics: Adenoma, Islet Cell; Calcium; Carbachol; Chromogranin A; Genes, ras; Humans; Inositol 1,4,5-Trisphos | 1993 |
PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.
Topics: Amino Acid Sequence; Animals; Carbachol; Cholecystokinin; In Vitro Techniques; Iodine Radioisotopes; | 1993 |
Cholecystokinin analog, JMV-180, stimulates growth of human pancreatic cancer.
Topics: Carbachol; Cell Count; DNA, Neoplasm; Humans; Pancreatic Neoplasms; Receptors, Cholecystokinin; Sinc | 1994 |
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995).
Topics: Adult; Atropine; Carbachol; Ceruletide; Dose-Response Relationship, Drug; Female; Humans; Immunohist | 1994 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis.
Topics: Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Carbachol; Chromogranin A; Exocytosis; Glyceral | 1996 |
Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting beta-cells.
Topics: Androstadienes; Animals; Carbachol; CHO Cells; Clone Cells; Cricetinae; Glucose; Humans; Insulin; In | 1996 |
Defective ATP-dependent mucin secretion by cystic fibrosis pancreatic epithelial cells.
Topics: Adenocarcinoma; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; A | 1996 |
Eicosapentaenoic acid (C20:5) augments glucose-induced insulin secretion from beta-TC3 insulinoma cells.
Topics: Calcium; Carbachol; Drug Synergism; Eicosapentaenoic Acid; Exocytosis; Glucose; Insulin; Insulin Sec | 1996 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; G | 1997 |
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Topics: 3T3 Cells; Aluminum Compounds; Animals; Antibodies, Monoclonal; Astrocytes; Carbachol; Cell Line; CH | 1997 |
Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.
Topics: Animals; Carbachol; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin S | 1998 |
A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells.
Topics: Alanine; Animals; Calcium; Carbachol; Cricetinae; Cytosol; Energy Metabolism; Glucagon; Glucagonoma; | 1999 |
Pertussis toxin non-sensitive G protein mediates cholinergic stimulation for secretion of pancreastatin and somatostatin from QGP-1N cells.
Topics: Calcium; Carbachol; Chromogranin A; GTP-Binding Proteins; Humans; Pancreatic Hormones; Pancreatic Ne | 1992 |
Interaction between phosphoinositide turnover system and cyclic AMP pathway for the secretion of pancreastatin and somatostatin from QGP-1N cells.
Topics: Adenoma, Islet Cell; Atropine; Bucladesine; Calcimycin; Carbachol; Cell Line; Chromogranin A; Colfor | 1992 |
Acetylcholine regulates pancreastatin secretion from the human pancreastatin-producing cell line (QGP-1N).
Topics: Acetylcholine; Adenoma, Islet Cell; Atropine; Calcimycin; Calcium; Carbachol; Chromogranin A; Gastri | 1991 |
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Sy | 1990 |
Gastrointestinal peptides activate Na(+)-H+ exchanger in AR42J cells by increasing its affinity for intracellular H+.
Topics: Amiloride; Amino Acid Sequence; Animals; Bombesin; Carbachol; Carrier Proteins; Cell Line; Gastroint | 1990 |
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans; | 1987 |
Phorbol ester-stimulated insulin secretion by RINm5F insulinoma cells is linked with membrane depolarization and an increase in cytosolic free Ca2+ concentration.
Topics: Adenoma, Islet Cell; Animals; Benzofurans; Calcium; Carbachol; Cell Line; Cell Membrane; Cytosol; Et | 1989 |
Muscarinic cholinergic receptors in pancreatic acinar carcinoma of rat.
Topics: Adenocarcinoma; Amylases; Animals; Atropine; Binding, Competitive; Carbachol; Carcinoma; Dexetimide; | 1985 |
Identification and characterization of muscarinic receptors in cultured human pancreatic carcinoma cells.
Topics: Atropine; Carbachol; Cell Line; Humans; Inositol Phosphates; Kinetics; N-Methylscopolamine; Pancreat | 1989 |
Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr).
Topics: Adenoma, Islet Cell; Animals; Carbachol; Cell Membrane; Enzyme Activation; Inositol Phosphates; Insu | 1988 |
Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Calcium; Carbachol; Cell Line; Cytosol; Fluorometry; Homeostasis; Insu | 1988 |
Gastrin secretion by gastrinoma cells in long-term culture.
Topics: Bombesin; Bucladesine; Calcimycin; Calcium; Carbachol; Culture Media; Gastrinoma; Gastrins; Humans; | 1988 |
Glucose-stimulated sequestration of Ca2+ in clonal insulin-releasing cells. Evidence for an opposing effect of muscarinic-receptor activation.
Topics: Adenoma, Islet Cell; Animals; Atropine; Calcium; Carbachol; Cell Line; Clone Cells; Glucose; Insulin | 1986 |
Glucose induces insulin release and a rise in cytosolic calcium concentration in a transplantable rat insulinoma.
Topics: Adenoma, Islet Cell; Aminoquinolines; Animals; Calcium; Carbachol; Cytosol; Dose-Response Relationsh | 1986 |
Phospholipase C activation via a GTP-binding protein in tumoral islet cells stimulated by carbamylcholine.
Topics: Adenoma, Islet Cell; Carbachol; Cell Line; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-( | 1987 |
Muscarinic receptor coupling to intracellular calcium release in rat pancreatic acinar carcinoma.
Topics: Animals; Binding, Competitive; Calcium; Carbachol; Carcinoma; N-Methylscopolamine; Oxotremorine; Pan | 1986 |