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carbachol and Obesity

carbachol has been researched along with Obesity in 23 studies

Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"Here, we described the effects of obesity induced by high-calorie diet and its treatment with exenatide, an anti-diabetogenic and potential anti-obesogenic drug derived from the venom of the Gila monster Heloderma suspectum, on the affinity, density, subtypes and intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors (mAChRs) in rat hippocampus."7.91Effects of obesity induced by high-calorie diet and its treatment with exenatide on muscarinic acetylcholine receptors in rat hippocampus. ( Abdalla, FMF; Alponti, RF; Alves, PL; Silva, MFP; Silveira, PF, 2019)
"Here, we described the effects of obesity induced by high-calorie diet and its treatment with exenatide, an anti-diabetogenic and potential anti-obesogenic drug derived from the venom of the Gila monster Heloderma suspectum, on the affinity, density, subtypes and intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors (mAChRs) in rat hippocampus."3.91Effects of obesity induced by high-calorie diet and its treatment with exenatide on muscarinic acetylcholine receptors in rat hippocampus. ( Abdalla, FMF; Alponti, RF; Alves, PL; Silva, MFP; Silveira, PF, 2019)
"To evaluate the effects of the beta-3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity."3.85Long-term treatment with the beta-3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice. ( Alexandre, EC; Antunes, E; Calmasini, FB; Candido, TZ; da Silva, CPV; da Silva, FH; de Oliveira, MG; Mónica, FZ, 2017)
" Metformin treatment improved the insulin sensitivity, and normalized the in vitro bladder hypercontractility and cystometric dysfunction in obese mice."3.78Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice. ( Anhê, GF; Antunes, E; Calixto, MC; De Nucci, G; Grant, AD; Leiria, LO; Lintomen, L; Mónica, FZ; Sollon, C; Zanesco, A, 2012)
"A single gene deletion causes lack of leptin and obesity in B6."3.75Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. ( Baghdoyan, HA; Lydic, R; Wang, W, 2009)
"Determining how obesity affects function in human myometrial arteries, to help understand why childbirth has poor outcomes in obese women."1.51Human myometrial artery function and endothelial cell calcium signalling are reduced by obesity: Can this contribute to poor labour outcomes? ( Prendergast, C; Wray, S, 2019)
"Carbachol did not enhance glucose-induced insulin secretion in islets from 9- to 10-month-old ob/ob mice in the presence of low extracellular Na concentration."1.32Effects of cholinergic m-receptor agonists on insulin release in islets from obese and lean mice of different ages: the importance of bicarbonate. ( Lindström, P; Persson-Sjögren, S, 2004)
"h-1) evoked a characteristic biphasic dose-response curve for pancreatic juice and protein output in the LETO rats, whereas the OLETF rats were totally insensitive to CCK-8 stimulation."1.29Defect in pancreatic exocrine and endocrine response to CCK in genetically diabetic OLETF rats. ( Akiyama, T; Furumi, K; Kanagawa, K; Otsuki, M; Shiohara, H; Tachibana, I; Watanabe, N, 1996)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's3 (13.04)18.2507
2000's7 (30.43)29.6817
2010's9 (39.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Silva, MFP1
Alves, PL1
Alponti, RF1
Silveira, PF1
Abdalla, FMF1
Yamamoto, J1
Imai, J1
Izumi, T1
Takahashi, H1
Kawana, Y1
Takahashi, K1
Kodama, S1
Kaneko, K1
Gao, J1
Uno, K1
Sawada, S1
Asano, T1
Kalinichenko, VV1
Susaki, EA1
Kanzaki, M1
Ueda, HR1
Ishigaki, Y1
Yamada, T1
Katagiri, H1
Orfanos, S1
Jude, J1
Deeney, BT1
Cao, G1
Rastogi, D1
van Zee, M1
Pushkarsky, I1
Munoz, HE1
Damoiseaux, R1
Di Carlo, D1
Panettieri, RA1
Prendergast, C1
Wray, S1
Lubaczeuski, C2
Balbo, SL3
Ribeiro, RA2
Vettorazzi, JF1
Santos-Silva, JC1
Carneiro, EM3
Bonfleur, ML3
Mendes, MC1
Maller, AC1
Calmasini, FB1
de Oliveira, MG1
Alexandre, EC1
da Silva, FH1
da Silva, CPV1
Candido, TZ1
Antunes, E2
Mónica, FZ2
Wang, W1
Baghdoyan, HA1
Lydic, R1
Andreazzi, AE1
Grassiolli, S1
Marangon, PB1
Martins, AG1
de Oliveira, JC1
Torrezan, R1
Gravena, C1
Garcia, RM1
Mathias, PC2
Leiria, LO1
Sollon, C1
Calixto, MC1
Lintomen, L1
Anhê, GF1
De Nucci, G1
Zanesco, A1
Grant, AD1
Amaral, ME1
Filiputti, E1
Persson-Sjögren, S1
Lindström, P1
Yoshimura, R2
Omori, H2
Somekawa, S2
Osaka, T1
Ito, R1
Inoue, S1
Endo, Y2
Zawalich, WS2
Kelley, GG1
Tachibana, I1
Akiyama, T1
Kanagawa, K2
Shiohara, H1
Furumi, K1
Watanabe, N1
Otsuki, M2
Nakamura, H1
Kihara, Y1
Tashiro, M1
Shirohara, H1
Yamamoto, M1
Yoshikawa, H1
Fukumitsu, K1
Hirohata, Y1
Zawalich, KC1
Naderali, EK1
Williams, G1
Trimble, ER1
Bruzzone, R1
Lundquist, I1
Saunders, WS1
Thornhill, JA1
Wayner, MJ1
Carey, RJ1

Reviews

2 reviews available for carbachol and Obesity

ArticleYear
The pathogenesis of NIDDM: the role of the pancreatic beta cell.
    Diabetologia, 1995, Volume: 38, Issue:8

    Topics: Animals; Carbachol; Cholinergic Agents; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose; Human

1995
Basic drives.
    Annual review of psychology, 1973, Volume: 24

    Topics: Animals; Appetite Regulation; Atropine; Behavior, Animal; Body Temperature Regulation; Body Weight;

1973

Other Studies

21 other studies available for carbachol and Obesity

ArticleYear
Effects of obesity induced by high-calorie diet and its treatment with exenatide on muscarinic acetylcholine receptors in rat hippocampus.
    Biochemical pharmacology, 2019, Volume: 169

    Topics: Animals; Carbachol; Energy Intake; Exenatide; Glucagon-Like Peptide-1 Receptor; Hippocampus; Male; O

2019
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism.
    Nature communications, 2017, 12-05, Volume: 8, Issue:1

    Topics: Animals; Blood Glucose; Brain; Carbachol; Cell Proliferation; Cholinergic Agonists; Forkhead Box Pro

2017
Obesity increases airway smooth muscle responses to contractile agonists.
    American journal of physiology. Lung cellular and molecular physiology, 2018, 11-01, Volume: 315, Issue:5

    Topics: Adult; Asthma; Calcium; Carbachol; Cardiotonic Agents; Case-Control Studies; Cells, Cultured; Female

2018
Human myometrial artery function and endothelial cell calcium signalling are reduced by obesity: Can this contribute to poor labour outcomes?
    Acta physiologica (Oxford, England), 2019, Volume: 227, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Arginine Vasopressin; Art

2019
Vagotomy ameliorates islet morphofunction and body metabolic homeostasis in MSG-obese rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:5

    Topics: Animals; Carbachol; Cell Count; Cholesterol; Cholinergic Agonists; Flavoring Agents; Glucose; Homeos

2015
Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.
    Journal of physiology and biochemistry, 2016, Volume: 72, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Body Weight; Carbachol; Colforsin; Cyclic AMP;

2016
Long-term treatment with the beta-3 adrenoceptor agonist, mirabegron ameliorates detrusor overactivity and restores cyclic adenosine monophosphate (cAMP) levels in obese mice.
    Neurourology and urodynamics, 2017, Volume: 36, Issue:6

    Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Body Weight; Carbachol; Cyclic AMP; Cycl

2017
Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice.
    The journal of pain, 2009, Volume: 10, Issue:8

    Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Hot T

2009
Impaired sympathoadrenal axis function contributes to enhanced insulin secretion in prediabetic obese rats.
    Experimental diabetes research, 2011, Volume: 2011

    Topics: Adrenal Medulla; Animals; Blood Glucose; Caffeine; Carbachol; Catecholamines; Glucose Tolerance Test

2011
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Adiposity; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Cal

2012
Parasympathetic activity changes insulin response to glucose and neurotransmitters.
    Diabetes & metabolism, 2002, Volume: 28, Issue:6 Pt 2

    Topics: Analysis of Variance; Animals; Carbachol; Glucose; In Vitro Techniques; Islets of Langerhans; Kineti

2002
Effects of cholinergic m-receptor agonists on insulin release in islets from obese and lean mice of different ages: the importance of bicarbonate.
    Pancreas, 2004, Volume: 29, Issue:4

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcholine; Age Factors; Amiloride; Ammonium Ch

2004
Continuous carbachol infusion promotes peripheral cell proliferation and mimics vagus hyperactivity in a rat model of hypothalamic obesity.
    Biomedical research (Tokyo, Japan), 2006, Volume: 27, Issue:2

    Topics: Animals; Body Weight; Carbachol; Cell Proliferation; Cholinergic Agonists; Disease Models, Animal; D

2006
Carbachol induces hepatocyte proliferation, but only in the presence of hepatic nonparenchymal cells.
    The journal of physiological sciences : JPS, 2007, Volume: 57, Issue:3

    Topics: Animals; Carbachol; Cell Proliferation; Cells, Cultured; Cholinergic Agonists; Coculture Techniques;

2007
Defect in pancreatic exocrine and endocrine response to CCK in genetically diabetic OLETF rats.
    The American journal of physiology, 1996, Volume: 270, Issue:4 Pt 1

    Topics: Acute Disease; Animals; Carbachol; Caseins; Ceruletide; Cholecystokinin; Duodenum; Gastric Acid; Glu

1996
Defects of cholecystokinin (CCK)-A receptor gene expression and CCK-A receptor-mediated biological functions in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
    Journal of gastroenterology, 1998, Volume: 33, Issue:5

    Topics: Animals; Arginine; Blood Glucose; Blotting, Northern; Blotting, Southern; Brain; Carbachol; DNA Prim

1998
A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats.
    Endocrinology, 2000, Volume: 141, Issue:9

    Topics: Androstadienes; Animals; Calcium; Carbachol; Cell Separation; Enzyme Inhibitors; Glucose; Hyperinsul

2000
Effects of short-term feeding of a highly palatable diet on vascular reactivity in rats.
    European journal of clinical investigation, 2001, Volume: 31, Issue:12

    Topics: Aldehydes; Animal Feed; Animals; Arteriosclerosis; Carbachol; Cholinergic Agonists; Dietary Fats; En

2001
Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat.
    Regulatory peptides, 1985, Volume: 11, Issue:3

    Topics: Amylases; Animals; Blood Glucose; Body Weight; Carbachol; Ceruletide; Female; Homozygote; In Vitro T

1985
Lysosomal enzyme activities in pancreatic islets from normal and obese hyperglycemic mice.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:1

    Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; Blood Glucose; Carbachol; Cathepsin D; Fasting; Fe

1985
No inotropic action of enkephalins or enkephalin derivatives on electrically-stimulated atria isolated from lean and obese rats.
    British journal of pharmacology, 1985, Volume: 85, Issue:2

    Topics: Animals; Atrial Function; Carbachol; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-

1985