carbachol has been researched along with Neuroblastoma in 262 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carbachol-mediated activation of type M(3) muscarinic acetylcholine receptors induces the biosynthesis of the transcription factor Egr-1 in human SH-SY5Y neuroblastoma cells involving an activation of extracellular signal-regulated protein kinase." | 7.74 | Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells. ( Henss, I; Rössler, OG; Thiel, G, 2008) |
| " Here, the effect of the muscarinic agonist carbachol on NPY biosynthesis and release was analyzed utilizing the SH-SY5Y human neuroblastoma cell line." | 7.74 | Cholinergic regulation of neuropeptide Y synthesis and release in human neuroblastoma cells. ( Dozio, E; Feltrin, D; Magni, P; Motta, M; Ruscica, M, 2008) |
| "In human SH-SY5Y neuroblastoma cells, two distinct intracellular Ca2+ stores, a KCl-/caffeine-sensitive and a carbachol-/IP3-sensitive store, were demonstrated previously." | 7.72 | Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells. ( Blanck, TJ; Corrales, AV; Garavito-Aguilar, ZV; Recio-Pinto, E; Xu, F; Zhang, J, 2004) |
| " In this study, potential regulatory interactions between signal transduction systems activated by growth factor receptors and by G-protein-coupled receptors were examined using human neuroblastoma SH-SY5Y cells which express endogenous epidermal growth factor (EGF) and muscarinic M3 receptors." | 7.70 | Muscarinic M3 and epidermal growth factor receptors activate mutually inhibitory signaling cascades in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Zhang, L, 1999) |
| "The muscarinic receptor stimulated mobilisation of calcium ions in SH-SY5Y neuroblastoma cells was measured as a function on carbachol and atropine concentrations." | 7.70 | Influence of atropine on carbachol dual effect on Ca2+ mobilization in SH-SY5Y neuroblastoma cells. ( Akerman, KE; Järv, J; Oras, A, 1999) |
| "Pituitary adenylyl cyclase activating polypeptide (PACAP-27), forskoline and carbachol increased type A atrial natriuretic peptide receptor (NPR-A) density, as well as NPR-A mRNA level, in the human neuroblastoma NB-OK-1 cell line." | 7.70 | Human A-type ANP receptor upregulation by PACAP and carbachol in neuroblastoma cells. ( Delporte, C; Forgeur, A; Robberecht, P; Svoboda, M; Winand, J, 1999) |
| "Lithium, carbamazepine and sodium valproate are mood stabilizers used in the treatment of bipolar disorder, and although their mechanisms of action remain unknown, signal transduction systems and the associated modulation of gene expression may constitute significant actions." | 7.70 | Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Pacheco, MA, 1999) |
| "We have investigated the effect of 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, on carbachol-induced increase in intracellular Ca2+ concentration ([Ca2+]i) in human neuroblastoma SH-SY5Y cells by means of single cell imaging of [Ca2+]i." | 7.70 | Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells. ( Kamisaki, Y; Maeda, S; Saeki, M, 2000) |
| " Muscarinic and bradykinin receptor-mediated Ins(1,4,5)P3 accumulation, Ca2+ mobilization and Ca2+ entry have been examined in human SH-SY5Y neuroblastoma cells." | 7.69 | Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells. ( Nahorski, SR; Willars, GB, 1995) |
| "The effect of ethanol on muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate was studied in human neuroblastoma SH-SY5Y cells." | 7.69 | Ethanol inhibits the peak of muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate in neuroblastoma SH-SY5Y cells. ( Alling, C; Hoek, JB; Larsson, C; Simonsson, P, 1995) |
| "We investigated the effects of lithium ion (Li+) on muscarinic receptor-mediated nitric oxide (NO) generation, and guanylate cyclase (GCase) activation using the mouse neuroblastoma clone, N1E-115." | 7.69 | Inhibition by lithium of cyclic GMP formation without inhibition of nitric oxide generation in the mouse neuroblastoma cell (N1E-115). ( Asai, M; Kanba, S; Kato, R; Nakaki, T; Nakamura, R; Richelson, E; Sato, K; Shintani, F; Yagi, G, 1994) |
| "Electrically permeabilized SH-SY5Y neuroblastoma cells have been used to examine the relationship between receptor occupation by muscarinic agonists, inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) accumulation and Ca2+ mobilization from intracellular stores." | 7.69 | A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells. ( Nahorski, SR; Safrany, ST, 1994) |
| "We have examined the effect of fentanyl on [3H]noradrenaline release in a human neuroblastoma cell preparation, SH-SY5Y." | 7.69 | Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Lambert, DG; Rowbotham, DJ, 1994) |
| " Using SH-SY5Y human neuroblastoma cells we have demonstrated that halothane (0." | 7.69 | Halothane and isoflurane enhance basal and carbachol-stimulated inositol(1,4,5)triphosphate formation in SH-SY5Y human neuroblastoma cells. ( Lambert, DG; Smart, D; Smith, G, 1994) |
| "Suspended cells of the human neuroblastoma line SK-N-SH were exposed to elevated pressures of non-narcotic helium (He) and the narcotic gases nitrogen (N2), and argon (Ar) and stimulated with carbachol." | 7.69 | Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome. ( Dixon, SJ; Kalogeros, G; McIver, DJ; Philp, RB, 1994) |
| " Here we report on the effects of elevated pressures of He, and of 1 atm abs of the anesthetic gas nitrous oxide (N2O), when present alone and in combination, on calcium mobilization in the human neuroblastoma cell line SK-N-SH." | 7.69 | Pressure antagonism of nitrous oxide depression of intracellular calcium in a neuroblastoma cell line. ( Kalogeros, G; Philp, RB; Resendes, MC, 1996) |
| "We have examined the effects of two intravenous anaesthetic induction agents, propofol and thiopentone, on K+ and carbachol evoked [3H]noradrenaline release from a human neuroblastoma cell line, SH-SY5Y." | 7.69 | Effects of propofol and thiopentone on potassium- and carbachol-evoked [3H]noradrenaline release and increased [Ca2+]i from SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Frost, C; Lambert, DG; Rowbotham, DJ; Smart, D; Smith, G; Willets, JM, 1996) |
| "The effects of arginine on calcium mobilization in human SK-N-SH neuroblastoma cells were examined." | 7.69 | Arginine-modulated receptor-activated calcium influx via a NO/cyclic GMP pathway in human SK-N-SH neuroblastoma cells. ( Liu, PS; Shaw, YH, 1997) |
| " In this study we have investigated neuropeptide Y (NPY) and somatostatin (SRIF) receptor-mediated elevation of intracellular Ca2+ concentration ([Ca2+]i) in the human neuroblastoma cell line SH-SY5Y." | 7.69 | Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. ( Connor, M; Henderson, G; Yeo, A, 1997) |
| "The ability of angiotensin II (AII) to regulate [Ca++]i in human neuroblastoma (SH-SY5Y) cells stably expressing recombinant rat AT1A receptors was investigated using microfluorimetric methods, and compared to responses obtained by stimulation of native muscarinic receptors." | 7.69 | Regulation of [Ca++]i in human neuroblastoma (SH-SY5Y) cells expressing recombinant rat angiotensin1A receptors by angiotensin II and carbachol. ( Ball, SG; McDonald, RL; Palmer, AC; Peers, C; Roberts, DJ; Vaughan, PF, 1997) |
| "Fura 2 imaging was used to measure intracellular Ca2+ signals in N1E-115 mouse neuroblastoma cells during combined activation of bradykinin (BK) and cholinergic receptors." | 7.69 | Cholinergic modulation of the Ca2+ response to bradykinin in neuroblastoma cells. ( Coggan, JS; Thompson, SH, 1997) |
| "We have examined the effects of the volatile general anaesthetic agent, halothane, on K+ and carbachol stimulated [3H]noradrenaline release and associated increases in intracellular Ca2+ in a cultured human neuroblastoma cell line, SH-SY5Y." | 7.69 | Effect of halothane on K+ and carbachol stimulated [3H]noradrenaline release and increased [Ca2+]i in SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Bjornstrom, K; Hirst, RA; Lambert, DG; Rowbotham, DJ, 1997) |
| "We have examined the effects of the intravenous anaesthetic induction agent etomidate on K+ and carbachol evoked [3H]noradrenaline ([3H]NA) release and the associated increase in [Ca2+]i in SH-SY5Y human neuroblastoma cells in a attempt to study potential anaesthetic target site(s)." | 7.69 | Etomidate inhibits [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells. ( Hirota, K; Lambert, DG; Sikand, KS; Smith, G, 1997) |
| "In order to identify potential actions of lithium, the primary therapeutic agent for bipolar affective disorder, on processes regulating gene expression, its effects on two transcription factors, AP-1 and NF-kappaB, were measured in human neuroblastoma SH-SY5Y cells." | 7.69 | AP-1 and NF-kappaB stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium. ( Jope, RS; Song, L, 1997) |
| "Neuroblastoma cells were used to examine the effect of chronic exposure to increased concentrations of glucose, galactose, or L-fucose on bradykinin-stimulated intracellular calcium release using the calcium indicator fluo-3." | 7.68 | Effect of bradykinin on cytosolic calcium in neuroblastoma cells using the fluorescent indicator fluo-3. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993) |
| " SH-SY5Y human neuroblastoma cells were exposed to carbachol, permeabilized electrically, loaded with 45Ca2+, and 45Ca2+ mobilization in response to exogenous InsP3 was assessed." | 7.68 | Chronic muscarinic stimulation of SH-SY5Y neuroblastoma cells suppresses inositol 1,4,5-trisphosphate action. Parallel inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ mobilization and inositol 1,4,5-trisphosphate binding. ( Nahorski, SR; Wojcikiewicz, RJ, 1991) |
| "We have investigated the modulatory action of carbachol on intracellular cAMP levels in human neuroblastoma SH-SY5Y cells." | 7.68 | Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells. ( Nakagawa-Yagi, Y; Saito, Y; Takada, Y; Takayama, M, 1991) |
| " Carbachol stimulated the rate of inositol phospholipid breakdown in IMR-32 and SK-N-MC human neuroblastoma cells with an EC50 value of about 50 microM in both cases." | 7.68 | Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells. ( Ahlgren, PC; Fowler, CJ; O'Neill, C, 1991) |
| "The human neuroblastoma clone SH-SY5Y expresses potassium-, carbachol-, and calcium ionophore A23187-evoked, calcium-dependent release of [3H]noradrenaline." | 7.68 | Potassium- and carbachol-evoked release of [3H]noradrenaline from human neuroblastoma cells, SH-SY5Y. ( Ball, SG; Murphy, NP; Vaughan, PF, 1991) |
| "Electrically permeabilised [3H]inositol-labelled SH-SY5Y human neuroblastoma cells were employed to examine the effects of two synthetic, phosphatase-resistant analogues of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] on the metabolism of cell membrane-derived [3H]Ins(1,4,5)P3 or exogenous [5-32P]Ins(1,4,4)P3." | 7.68 | Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate. ( Cooke, AM; Nahorski, SR; Potter, BV; Wojcikiewicz, RJ, 1990) |
| "This study reports increased intracellular Ca2+ and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] in response to muscarinic-cholinergic stimulation of human neuroblastoma (SH-SY5Y) cells." | 7.68 | Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y. ( Lambert, DG; Nahorski, SR, 1990) |
| "In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence." | 7.67 | Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells. ( Deguchi, T; Ohsako, S, 1984) |
| "The lipophilic permeant cation [3H]triphenylmethylphosphonium (TPMP) was used to estimate membrane potential in neuroblastoma N1E 115 cells under carefully controlled conditions." | 7.67 | Use of [3H]triphenylmethylphosphonium cation for estimating membrane potential in neuroblastoma cells. ( Milligan, G; Strange, PG, 1984) |
| "Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques." | 7.67 | Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells. ( Hedlund, B, 1987) |
| "The effects of mastoparan on phospholipase C-catalysed phosphoinositide hydrolysis were examined in [3H]inositol-labelled human neuroblastoma SH-SY5Y cells." | 7.67 | Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan. ( Nahorski, SR; Wojcikiewicz, RJ, 1989) |
| "Short-term agonist-induced loss of cell surface muscarinic receptors and desensitization of receptor-mediated cyclic GMP (cGMP) formation and phosphoinositide hydrolysis were examined in mouse neuroblastoma cells (clone N1E-115) in suspension." | 7.67 | Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors. ( Cioffi, CL; el-Fakahany, EE, 1989) |
| "Because previous studies in whole-animal models have reported inconsistent results regarding the effect of chronic lithium on the regulation of the neuronal muscarinic acetylcholine receptor (mAChR) number, we examined the effect of chronic lithium on the regulation of mAChR in cell cultures of N1E-115, a mouse neuroblastoma clone." | 7.67 | Alteration in the regulation of neuronal muscarinic acetylcholine receptor number induced by chronic lithium in neuroblastoma cells. ( Liles, WC; Nathanson, NM, 1988) |
| "The effects of brief incubation with carbamylcholine on subsequent binding of [3H]N-methylscopolamine were investigated in mouse neuroblastoma cells (clone N1E-115)." | 7.67 | Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites. ( Cioffi, CL; el-Fakahany, EE, 1986) |
| "The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied." | 7.67 | Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells. ( el-Fakahany, EE; Lai, WS, 1987) |
| "Mouse N1E-115 neuroblastoma cells were used to study carbachol induced changes in muscarinic cholinergic parameters." | 7.67 | Exposure to carbachol induces several changes in muscarinic cholinergic parameters in N1E-115 mouse neuroblastoma cells. ( Hedlund, B; Lorentz, M; Reintam, AC; Sydbom, A, 1988) |
| "The binding characteristics of [3H]phorbol-12,13-dibutyrate ([3H]PDBu) in mouse neuroblastoma N1E-115 cells were studied." | 7.67 | Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function. ( el-Fakahany, EE; Lai, WS, 1988) |
| "Incubation of mouse neuroblastoma cells (clone N1E-115) with Mn2+ resulted in a rapid and transient increase in cyclic GMP formation." | 7.66 | Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells. ( El-Fakahany, E; Richelson, E, 1980) |
| "Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells." | 7.66 | Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells. ( Richelson, E, 1978) |
| "Carbachol-pretreated SH-SY5Y cells (1 mM, > or 6 hr) exhibit a decrease in Ins(1,4,5)P3 receptor number, accompanied by both a rightward shift and a reduced maximal Ca2+ release in their Ins(1,4,5)P3 concentration-response curve." | 5.29 | Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells. ( Challiss, RA; Liu, C; Nahorski, SR; Potter, BV; Wilcox, RA, 1993) |
| " The dose-response curve for this suppression was very similar to that for stimulation of inositol monophosphate (IP1) formation and for stimulation of the initial rise of [Ca2+]i elicited by carbachol." | 5.28 | Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells. ( Nakagawa-Yagi, Y; Nakamura, H; Saito, Y; Takada, Y, 1992) |
| " We treated SH-SY5Y neuroblastoma cells with carbachol, a cholinergic agonist, and tested for bioenergetic flux and bioenergetic infrastructure changes." | 3.79 | Effect of cholinergic signaling on neuronal cell bioenergetics. ( Burns, JM; E, L; Funk, E; Hutfles, L; Lu, J; Roy, N; Selfridge, E; Swerdlow, RH, 2013) |
| " Using serum starved SK-N-SH neuroblastoma cells, we show that the muscarinic receptor agonists carbachol and pilocarpine enhance the activation of the mTOR substrate p70 S6 Kinase (S6K) and its target ribosomal protein S6 (S6) in a VEGFR2 dependent manner." | 3.77 | Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells. ( Cao, Q; Edelstein, J; Hao, T; Morales, L; Rockwell, P, 2011) |
| " Here, the effect of the muscarinic agonist carbachol on NPY biosynthesis and release was analyzed utilizing the SH-SY5Y human neuroblastoma cell line." | 3.74 | Cholinergic regulation of neuropeptide Y synthesis and release in human neuroblastoma cells. ( Dozio, E; Feltrin, D; Magni, P; Motta, M; Ruscica, M, 2008) |
| " In the present study, we analyzed effects of hypoxia and oxidative stress on ECE-1 in human neuroblastoma NB7 cells and effects of the cholinergic agonist carbachol and the phorbol ester, phorbol 12-myristate 13-acetate (PMA)." | 3.73 | Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells. ( Fisk, L; Nalivaeva, NN; Turner, AJ, 2006) |
| "Basal cytotoxicity, morphological changes and alterations in cell physiological and neurochemical functions were studied in differentiated human neuroblastoma (SH-SY5Y) cells during exposure to acrylamide and during a subsequent recovery period after cessation of exposure." | 3.72 | Acrylamide-induced effects on general and neurospecific cellular functions during exposure and recovery. ( Forsby, A; Kjellstrand, P; Nordin-Andersson, M; Walum, E, 2003) |
| "In human SH-SY5Y neuroblastoma cells, two distinct intracellular Ca2+ stores, a KCl-/caffeine-sensitive and a carbachol-/IP3-sensitive store, were demonstrated previously." | 3.72 | Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells. ( Blanck, TJ; Corrales, AV; Garavito-Aguilar, ZV; Recio-Pinto, E; Xu, F; Zhang, J, 2004) |
| " Here, we investigate the mechanisms of action of the AChEI donepezil on APP (amyloid precursor protein) metabolism and on the activity/trafficking of the alpha-secretase candidate ADAM 10, in differentiated human neuroblastoma cells (SH-SY5Y)." | 3.72 | Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. ( Borroni, B; Cattabeni, F; Colciaghi, F; Di Luca, M; Gardoni, F; Marcello, E; Padovani, A; Zimmermann, M, 2004) |
| " In SK-N-SH neuroblastoma cells, treatment with the cholinergic agonist carbachol led to maximal induction of EGR1 1 h after stimulation." | 3.71 | Muscarinic receptor-mediated phosphorylation of cyclic AMP response element binding protein in human neuroblastoma cells. ( Dragunow, M; Greenwood, JM, 2002) |
| "Human neuroblastoma SH-SY5Y cells, predominantly expressing type 1 inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R), were stably transfected with IP(3)R type 3 (IP(3)R3) cDNA." | 3.71 | IP(3)-mediated Ca(2+) signals in human neuroblastoma SH-SY5Y cells with exogenous overexpression of type 3 IP(3) receptor. ( Callewaert, G; De Smedt, H; De Smet, P; Missiaen, L; Nadif Kasri, N; Parys, JB; Van Acker, K, 2002) |
| "We have investigated the acute and chronic effect of metrifonate (MTF) and dichlorvos (DDVP), respectively the prodrug and active acetylcholinesterase inhibitor, on the secretory processing of the amyloid precursor protein (APP) in SH-SY5Y neuroblastoma cells." | 3.71 | Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein. ( Caprera, A; Govoni, S; König, G; Racchi, M; Sironi, M, 2001) |
| " To do this the activation of the AP-1 and NF-kappaB transcription factors and of the phosphoinositide second-messenger system was measured in human neuroblastoma SH-SY5Y cells after exposure to the oxidants H2O2 or diamide, with or without prior depletion of cellular glutathione." | 3.70 | Glutathione depletion exacerbates impairment by oxidative stress of phosphoinositide hydrolysis, AP-1, and NF-kappaB activation by cholinergic stimulation. ( Jope, RS; Li, X; Song, L, 1998) |
| " In this study, potential regulatory interactions between signal transduction systems activated by growth factor receptors and by G-protein-coupled receptors were examined using human neuroblastoma SH-SY5Y cells which express endogenous epidermal growth factor (EGF) and muscarinic M3 receptors." | 3.70 | Muscarinic M3 and epidermal growth factor receptors activate mutually inhibitory signaling cascades in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Zhang, L, 1999) |
| " The pharmacological profile for drug competition toward I-Bgt binding to these recombinant alpha7-nAChR matches that of human native alpha7-nAChR naturally expressed in SH-SY5Y human neuroblastoma cells (rank order potency methyllycaconitine>1, 1-dimethyl-4-phenylpiperazinium>(-)nicotine>cytisine>carbamylch oli ne> /=d-tubocurarine)." | 3.70 | Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line. ( Fryer, J; Herl, J; Leonard, SS; Lucero, L; Lukas, RJ; Peng, JH, 1999) |
| "Pituitary adenylyl cyclase activating polypeptide (PACAP-27), forskoline and carbachol increased type A atrial natriuretic peptide receptor (NPR-A) density, as well as NPR-A mRNA level, in the human neuroblastoma NB-OK-1 cell line." | 3.70 | Human A-type ANP receptor upregulation by PACAP and carbachol in neuroblastoma cells. ( Delporte, C; Forgeur, A; Robberecht, P; Svoboda, M; Winand, J, 1999) |
| "Activation of muscarinic receptors in human neuroblastoma SH-SY5Y cells with carbachol stimulated a rapid and large increase in early growth response-1 (Egr-1, also called zif268 and NGF1-A) protein levels and DNA binding activity." | 3.70 | Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells. ( Grimes, CA; Jope, RS, 1999) |
| "Lithium, carbamazepine and sodium valproate are mood stabilizers used in the treatment of bipolar disorder, and although their mechanisms of action remain unknown, signal transduction systems and the associated modulation of gene expression may constitute significant actions." | 3.70 | Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Pacheco, MA, 1999) |
| "We have investigated the effect of 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, on carbachol-induced increase in intracellular Ca2+ concentration ([Ca2+]i) in human neuroblastoma SH-SY5Y cells by means of single cell imaging of [Ca2+]i." | 3.70 | Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells. ( Kamisaki, Y; Maeda, S; Saeki, M, 2000) |
| " Muscarinic and bradykinin receptor-mediated Ins(1,4,5)P3 accumulation, Ca2+ mobilization and Ca2+ entry have been examined in human SH-SY5Y neuroblastoma cells." | 3.69 | Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells. ( Nahorski, SR; Willars, GB, 1995) |
| "In SH-SY5Y human neuroblastoma cells, addition of acetylcholine or carbachol rapidly induces a transient protrusion of lamellipodia." | 3.69 | Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C. ( Rebhan, M; Rösner, H; Vacun, G, 1995) |
| "The effect of ethanol on muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate was studied in human neuroblastoma SH-SY5Y cells." | 3.69 | Ethanol inhibits the peak of muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate in neuroblastoma SH-SY5Y cells. ( Alling, C; Hoek, JB; Larsson, C; Simonsson, P, 1995) |
| "Measurement of the intracellular Ca2+ concentration ([Ca2+]i) in fura-2-loaded single cells of the human neuroblastoma line SH-SY5Y indicated coexpression of muscarinic and bradykinin receptors linked to activation of phosphoinositidase C (PIC)." | 3.69 | Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion? ( Nahorski, SR; Willars, GB, 1995) |
| " Ca release was observed in response to the muscarinic agonist carbachol by fura-2 imaging of N1E-115 neuroblastoma cells." | 3.69 | The lifetime of inositol 1,4,5-trisphosphate in single cells. ( Alousi, AA; Thompson, SH; Wang, SS, 1995) |
| "We investigated the effects of lithium ion (Li+) on muscarinic receptor-mediated nitric oxide (NO) generation, and guanylate cyclase (GCase) activation using the mouse neuroblastoma clone, N1E-115." | 3.69 | Inhibition by lithium of cyclic GMP formation without inhibition of nitric oxide generation in the mouse neuroblastoma cell (N1E-115). ( Asai, M; Kanba, S; Kato, R; Nakaki, T; Nakamura, R; Richelson, E; Sato, K; Shintani, F; Yagi, G, 1994) |
| "In this study, the signal cascade transducing carbachol stimulation into c-fos expression in SH-SY5Y neuroblastoma cells was investigated." | 3.69 | Mechanisms of muscarinic receptor-stimulated expression of c-fos in SH-SY5Y cells. ( Alling, C; Bergman, O; Gustavsson, L; Larsson, C; Simonsson, P, 1994) |
| "Electrically permeabilized SH-SY5Y neuroblastoma cells have been used to examine the relationship between receptor occupation by muscarinic agonists, inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) accumulation and Ca2+ mobilization from intracellular stores." | 3.69 | A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells. ( Nahorski, SR; Safrany, ST, 1994) |
| " The roles of both Ca2+ and adenosine 3':5'-cyclic monophosphate (cyclic AMP) in carbachol and K(+)-stimulated [3H]-noradrenaline release from SH-SY5Y human neuroblastoma cells were examined." | 3.69 | Studies on the mechanism of [3H]-noradrenaline release from SH-SY5Y cells: the role of Ca2+ and cyclic AMP. ( Atcheson, R; Hirst, RA; Lambert, DG; Rowbotham, DJ, 1994) |
| " In the present study, we report that Rab3A effector domain peptide (33-48) causes accumulation of inositol 1,4,5-trisphosphate (1,4,5-IP3) in permeabilized pancreatic acinar cells, hepatocytes, 3T3 fibroblasts, and SH-SY5Y neuroblastoma cells." | 3.69 | Synthetic Rab3A effector domain peptide stimulates inositol 1,4,5-trisphosphate production in various permeabilized cells. ( Piiper, A; Stryjek-Kaminska, D; Zeuzem, S, 1994) |
| "We have examined the effect of fentanyl on [3H]noradrenaline release in a human neuroblastoma cell preparation, SH-SY5Y." | 3.69 | Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Lambert, DG; Rowbotham, DJ, 1994) |
| "Stimulation of SH-SY5Y human neuroblastoma cells with carbachol, a muscarinic agonist, down-regulates the type I inositol 1,4,5-trisphosphate (InsP3) receptor by > 90% with maximal and half-maximal effects after approximately 6 h and approximately 1 h, respectively." | 3.69 | Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation. ( Furuichi, T; Mikoshiba, K; Nahorski, SR; Nakade, S; Wojcikiewicz, RJ, 1994) |
| " Using SH-SY5Y human neuroblastoma cells we have demonstrated that halothane (0." | 3.69 | Halothane and isoflurane enhance basal and carbachol-stimulated inositol(1,4,5)triphosphate formation in SH-SY5Y human neuroblastoma cells. ( Lambert, DG; Smart, D; Smith, G, 1994) |
| "Suspended cells of the human neuroblastoma line SK-N-SH were exposed to elevated pressures of non-narcotic helium (He) and the narcotic gases nitrogen (N2), and argon (Ar) and stimulated with carbachol." | 3.69 | Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome. ( Dixon, SJ; Kalogeros, G; McIver, DJ; Philp, RB, 1994) |
| " Here we report on the effects of elevated pressures of He, and of 1 atm abs of the anesthetic gas nitrous oxide (N2O), when present alone and in combination, on calcium mobilization in the human neuroblastoma cell line SK-N-SH." | 3.69 | Pressure antagonism of nitrous oxide depression of intracellular calcium in a neuroblastoma cell line. ( Kalogeros, G; Philp, RB; Resendes, MC, 1996) |
| "We have investigated the relevance of actin rearrangement to neurotransmitter release, in neuroblastoma cell line SH-SY5Y stimulated with carbachol (1 mM)." | 3.69 | Is actin polymerization relevant to neurosecretion? A study on neuroblastoma cells. ( Galli, CL; Marinovich, M; Viviani, B, 1996) |
| "We have examined the effects of two intravenous anaesthetic induction agents, propofol and thiopentone, on K+ and carbachol evoked [3H]noradrenaline release from a human neuroblastoma cell line, SH-SY5Y." | 3.69 | Effects of propofol and thiopentone on potassium- and carbachol-evoked [3H]noradrenaline release and increased [Ca2+]i from SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Frost, C; Lambert, DG; Rowbotham, DJ; Smart, D; Smith, G; Willets, JM, 1996) |
| "The opiate agonist etorphine elevated [Ca2+]i in two neuroblastoma cell lines." | 3.69 | Determinants of the stimulatory opioid effect on intracellular calcium in SK-N-SH and NG108-15 neuroblastoma. ( Gafni, M; Sarne, Y, 1996) |
| " To test whether oxidative stress could contribute to deficits in cholinergic signaling, responses to carbachol were measured in human neuroblastoma SH-SY5Y cells exposed to H2O2." | 3.69 | Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis. ( Jope, RS; Li, X; Song, L, 1996) |
| " [3H](+)-pentazocine binding in BE(2)-C human neuroblastoma cells is high affinity (KD 3." | 3.69 | Sigma binding in a human neuroblastoma cell line. ( Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM, 1996) |
| " We herein report that, in a human neuroblastoma cell line, the somatostatin analogue BIM 23014 inhibited mitogen-activated protein (MAP) kinase activity stimulated by either insulin-like growth factor-1, whose receptor bears a tyrosine kinase, or carbachol, which acts at a G-protein coupled receptor." | 3.69 | A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines. ( Amoroso, D; Cattaneo, MG; Gussoni, G; Sanguini, AM; Vicentini, LM, 1996) |
| "5(10)-trien-17-yl]amino]hexyl]-1 H-pyrrole-2,5-dione (U-73122), an inhibitor of processes involved in the activation of phospholipase C, was used to assess the role of phospholipase C activation in the synergistic elevation of cAMP induced by carbachol and prostaglandin E2 in human neuroblastoma (SK-N-BE(2)C cells." | 3.69 | Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells. ( Kim, KT; Park, TJ; Suh, BC, 1996) |
| "The effects of arginine on calcium mobilization in human SK-N-SH neuroblastoma cells were examined." | 3.69 | Arginine-modulated receptor-activated calcium influx via a NO/cyclic GMP pathway in human SK-N-SH neuroblastoma cells. ( Liu, PS; Shaw, YH, 1997) |
| " In this study we have investigated neuropeptide Y (NPY) and somatostatin (SRIF) receptor-mediated elevation of intracellular Ca2+ concentration ([Ca2+]i) in the human neuroblastoma cell line SH-SY5Y." | 3.69 | Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. ( Connor, M; Henderson, G; Yeo, A, 1997) |
| "Stimulation of human SH-SY5Y neuroblastoma cells by a muscarinic receptor agonist, carbachol (CCh; 1 mM), elevated levels of free intracellular calcium and subsequently increased the production of reactive oxygen species (ROS)." | 3.69 | Cholinergic-induced production of reactive oxygen species in human neuroblastoma cells. ( Loikkanen, J; Naarala, J; Savolainen, K; Tervo, P, 1997) |
| "Fura 2 imaging was used to measure intracellular Ca2+ signals in N1E-115 mouse neuroblastoma cells during combined activation of bradykinin (BK) and cholinergic receptors." | 3.69 | Cholinergic modulation of the Ca2+ response to bradykinin in neuroblastoma cells. ( Coggan, JS; Thompson, SH, 1997) |
| " Despite rapid increases in internal Ins(1,4,5)P3 levels after stimulation with 1 mM carbachol, there was no change in external levels in both rat brain cortical slices and human neuroblastoma SH-SY5Y cells." | 3.69 | Studies of inositol phosphate export from neuronal tissue in vitro. ( Kendall, DA; Marsden, CA; Roberts, RE, 1997) |
| "We have examined the effects of the intravenous anaesthetic induction agent etomidate on K+ and carbachol evoked [3H]noradrenaline ([3H]NA) release and the associated increase in [Ca2+]i in SH-SY5Y human neuroblastoma cells in a attempt to study potential anaesthetic target site(s)." | 3.69 | Etomidate inhibits [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells. ( Hirota, K; Lambert, DG; Sikand, KS; Smith, G, 1997) |
| "Muscarinic receptor-mediated cyclic GMP formation and release of nitric oxide (NO) (or a precursor thereof) were compared in mouse neuroblastoma N1E-115 cells." | 3.68 | Role of intercellular and intracellular communication by nitric oxide in coupling of muscarinic receptors to activation of guanylate cyclase in neuronal cells. ( el-Fakahany, EE; Hu, J, 1993) |
| "Neuroblastoma cells were used to examine the effect of chronic exposure to increased concentrations of glucose, galactose, or L-fucose on bradykinin-stimulated intracellular calcium release using the calcium indicator fluo-3." | 3.68 | Effect of bradykinin on cytosolic calcium in neuroblastoma cells using the fluorescent indicator fluo-3. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993) |
| " We explored the possibility that APP processing is regulated by activation of endogenous cell-surface neurotransmitter receptors by stimulating C6, PC12 and neuroblastoma cells with the cholinergic agonist carbachol." | 3.68 | The cholinergic agonist carbachol reduces intracellular beta-amyloid precursor protein in PC 12 and C6 cells. ( Farlow, MR; Lahiri, DK; Nall, C, 1992) |
| "In SK-N-SH human neuroblastoma cells, the muscarinic agonist carbachol promotes polyphosphoinositide (PPI) hydrolysis via M3 receptors and increases cyclic AMP levels through an unidentified mechanism." | 3.68 | Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells. ( Gnegy, ME; Mangels, LA, 1992) |
| "SK-N-SH neuroblastoma cells grown under standard culture conditions contain significant amounts of Mead acid (20:3 omega 9) in phospholipids, indicating essential fatty acid (EFA) deficiency." | 3.68 | Essential fatty acid deficiency in cultured SK-N-SH human neuroblastoma cells. ( Agranoff, BW; Carlson, RO; Fisher, SK; Hajra, AK; Lee, C; Stubbs, EB, 1992) |
| "The addition of bradykinin to populations of fura-2 loaded N1E-115 neuroblastoma cells produced an increase in intracellular calcium which rapidly reached a peak and returned to baseline within 60 s." | 3.68 | Agonist-induced changes in [Ca2+]i in N1E-115 cells: differential effects of bradykinin and carbachol. ( Hill, SJ; Iredale, PA; Kendall, DA; Martin, KF, 1992) |
| "Quinacrine altered the equilibrium binding of the muscarinic antagonist quinuclidinyl benzilate (QNB) to the muscarinic receptor in membranes from N18TG2 neuroblastoma cells." | 3.68 | Muscarinic receptor binding is inhibited by quinacrine. ( Howlett, AC; O'Donnell, KA, 1991) |
| " SH-SY5Y human neuroblastoma cells were exposed to carbachol, permeabilized electrically, loaded with 45Ca2+, and 45Ca2+ mobilization in response to exogenous InsP3 was assessed." | 3.68 | Chronic muscarinic stimulation of SH-SY5Y neuroblastoma cells suppresses inositol 1,4,5-trisphosphate action. Parallel inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ mobilization and inositol 1,4,5-trisphosphate binding. ( Nahorski, SR; Wojcikiewicz, RJ, 1991) |
| "We have investigated the modulatory action of carbachol on intracellular cAMP levels in human neuroblastoma SH-SY5Y cells." | 3.68 | Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells. ( Nakagawa-Yagi, Y; Saito, Y; Takada, Y; Takayama, M, 1991) |
| "The effect of calcium channel antagonists on depolarization and carbachol evoked release of [3H]noradrenaline in the human neuroblastoma, SH-SY5Y, was investigated." | 3.68 | The effect of calcium channel antagonists on the release of [3H]noradrenaline in the human neuroblastoma, SH-SY5Y. ( Ball, SG; Murphy, NP; Vaughan, PF, 1991) |
| " Carbachol stimulated the rate of inositol phospholipid breakdown in IMR-32 and SK-N-MC human neuroblastoma cells with an EC50 value of about 50 microM in both cases." | 3.68 | Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells. ( Ahlgren, PC; Fowler, CJ; O'Neill, C, 1991) |
| "The human neuroblastoma clone SH-SY5Y expresses potassium-, carbachol-, and calcium ionophore A23187-evoked, calcium-dependent release of [3H]noradrenaline." | 3.68 | Potassium- and carbachol-evoked release of [3H]noradrenaline from human neuroblastoma cells, SH-SY5Y. ( Ball, SG; Murphy, NP; Vaughan, PF, 1991) |
| "We have investigated the coupling of muscarinic acetylcholine receptors (mAChR) to phospholipid hydrolysis in a human neuroblastoma cell line, LA-N-2, by measuring the formation of 3H-inositol phosphates (3H-IP) and of [3H]phosphatidylethanol ([3H]PEt) in cells prelabeled with [3H]inositol and [3H]oleic acid." | 3.68 | Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover. ( Sandmann, J; Wurtman, RJ, 1991) |
| "Preincubation with receptor agonists or phorbol esters desensitized muscarinic-receptor-mediated [3H]cyclic GMP responses in mouse neuroblastoma N1E-115 cells." | 3.68 | Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists. ( el-Fakahany, EE; Lai, WS; Rogers, TB, 1990) |
| "The contribution of polyphosphoinositides to muscarinic receptor-stimulated phosphoinositide turnover has been evaluated for intact and digitonin-permeabilized human SK-N-SH neuroblastoma cells." | 3.68 | Polyphosphoinositides are the major source of inositol phosphates in carbamoylcholine-stimulated SK-N-SH neuroblastoma cells. ( Agranoff, BW; Fisher, SK; Heacock, AM; Seguin, EB, 1990) |
| "Electrically permeabilised [3H]inositol-labelled SH-SY5Y human neuroblastoma cells were employed to examine the effects of two synthetic, phosphatase-resistant analogues of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] on the metabolism of cell membrane-derived [3H]Ins(1,4,5)P3 or exogenous [5-32P]Ins(1,4,4)P3." | 3.68 | Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate. ( Cooke, AM; Nahorski, SR; Potter, BV; Wojcikiewicz, RJ, 1990) |
| "The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), which causes differentiation of SH-SY5Y neuroblastoma cells, reduces carbachol binding and carbachol-stimulated Ca2+ mobilization in these cells." | 3.68 | 12-O-tetradecanoylphorbol 13-acetate and forskolin modify muscarinic receptor-linked Ca2+ mobilization in SH-SY5Y neuroblastoma cells through different mechanisms. ( Akerman, KE; Heikkilä, JE, 1990) |
| "This study reports increased intracellular Ca2+ and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] in response to muscarinic-cholinergic stimulation of human neuroblastoma (SH-SY5Y) cells." | 3.68 | Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y. ( Lambert, DG; Nahorski, SR, 1990) |
| "In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence." | 3.67 | Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells. ( Deguchi, T; Ohsako, S, 1984) |
| "The lipophilic permeant cation [3H]triphenylmethylphosphonium (TPMP) was used to estimate membrane potential in neuroblastoma N1E 115 cells under carefully controlled conditions." | 3.67 | Use of [3H]triphenylmethylphosphonium cation for estimating membrane potential in neuroblastoma cells. ( Milligan, G; Strange, PG, 1984) |
| "Short-term preincubation of mouse neuroblastoma cells (clone N1E-115) with the muscarinic agonist carbamylcholine at 37 degrees C resulted in a significant decrease in the binding of the muscarinic antagonist [3H]N-methylscopolamine." | 3.67 | Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells. ( El-Fakahany, EE; Feigenbaum, P, 1984) |
| "Responses of NlE-115 neuroblastoma cells to application of carbachol were studied using intracellular recording techniques." | 3.67 | Muscarinic receptors activate calcium channels and calcium dependent potassium channels in NlE-115 neuroblastoma cells. ( Arhem, P; Hedlund, B; Lorentz, M, 1987) |
| "Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques." | 3.67 | Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells. ( Hedlund, B, 1987) |
| "Intracellular calcium homeostasis and its modulation by different agents was studied in control and differentiated IMR32 human neuroblastoma cells by using the Ca2+-sensitive fluorescent dye quin2." | 3.67 | Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin. ( Clementi, F; Gotti, C; Madeddu, L; Pandiella, A; Sher, E, 1988) |
| "Chronic pertussis toxin treatment (5 days) of NG108-15 neuroblastoma X glioma hybrid cells had no significant effect on basal cyclic AMP levels whereas it effectively blocked the inhibitory action of acute (10 min) exposure of carbachol (10(-4)M) on intracellular cyclic AMP accumulation, stimulated by prostaglandin E1." | 3.67 | Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells. ( Askelöf, P; Bartfai, T; Gillenius, P; Westlind-Danielsson, A, 1988) |
| "The effects of mastoparan on phospholipase C-catalysed phosphoinositide hydrolysis were examined in [3H]inositol-labelled human neuroblastoma SH-SY5Y cells." | 3.67 | Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan. ( Nahorski, SR; Wojcikiewicz, RJ, 1989) |
| "Short-term agonist-induced loss of cell surface muscarinic receptors and desensitization of receptor-mediated cyclic GMP (cGMP) formation and phosphoinositide hydrolysis were examined in mouse neuroblastoma cells (clone N1E-115) in suspension." | 3.67 | Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors. ( Cioffi, CL; el-Fakahany, EE, 1989) |
| " We also investigated the effects of these same mediators on the c-GMP and/or c-AMP concentrations in HSV-latently infected trigeminal ganglion cells and in acyclovir-suppressed, HSV-infected neuroblastoma cells." | 3.67 | Cyclic nucleotide modulation of herpes simplex virus latency and reactivation. ( Foster, CS; Sainz de la Maza, M; Wells, PA, 1989) |
| "Carbachol (CCh)-stimulated hydrolysis of inositol lipids in human neuroblastoma SH-SY5Y cells was systematically characterized in parallel with the carbachol effects on cAMP formation." | 3.67 | The coupling of muscarinic receptors to hydrolysis of inositol lipids in human neuroblastoma SH-SY5Y cells. ( Mei, L; Roeske, WR; Yamamura, HI, 1989) |
| " The effects of the muscarinic agonist carbachol on phosphoinositide metabolism and its relationship to alteration of intracellular calcium were examined in SK-N-SH human neuroblastoma cells." | 3.67 | Muscarinic receptors coupled to phosphoinositide hydrolysis and elevated cytosolic calcium in a human neuroblastoma cell line SK-N-SH. ( Baird, JG; Lambert, DG; McBain, J; Nahorski, SR, 1989) |
| "The mechanisms of carbachol-induced muscarinic acetylcholine receptor (mAChR) down-regulation, and recovery following carbachol withdrawal, were studied in the neuroblastoma x glioma hybrid NG108-15 cell line by specific ligand binding assays." | 3.67 | Mechanism of agonist-induced down-regulation and subsequent recovery of muscarinic acetylcholine receptors in a clonal neuroblastoma x glioma hybrid cell line. ( Berman, JD; Middleton, W; Ray, P, 1989) |
| "Because previous studies in whole-animal models have reported inconsistent results regarding the effect of chronic lithium on the regulation of the neuronal muscarinic acetylcholine receptor (mAChR) number, we examined the effect of chronic lithium on the regulation of mAChR in cell cultures of N1E-115, a mouse neuroblastoma clone." | 3.67 | Alteration in the regulation of neuronal muscarinic acetylcholine receptor number induced by chronic lithium in neuroblastoma cells. ( Liles, WC; Nathanson, NM, 1988) |
| "Murine neuroblastoma cells (clone N1E-115) possess muscarinic receptors that mediate multiple responses, including the elevation of cyclic GMP levels and the inhibition of receptor-mediated increases in cyclic AMP." | 3.67 | Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115). Mediation of separate responses by high affinity and low affinity agonist-receptor conformations. ( McKinney, M; Richelson, E; Stenstrom, S, 1985) |
| "The effects of brief incubation with carbamylcholine on subsequent binding of [3H]N-methylscopolamine were investigated in mouse neuroblastoma cells (clone N1E-115)." | 3.67 | Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites. ( Cioffi, CL; el-Fakahany, EE, 1986) |
| "Chronic treatment of neuroblastoma X glioma hybrid cells (NG 108-15) with the muscarinic cholinergic agonist carbachol, which acutely inhibits adenylate cyclase, resulted in a 104 +/- 10% increase in PGE1-stimulated cAMP accumulation." | 3.67 | Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin. ( Hoffman, BB; Thomas, JM, 1986) |
| "The effects of phorbol 12-myristate 13-acetate (PMA) on carbamylcholine (CBC)-induced [3H]cyclic GMP formation in mouse neuroblastoma cells (clone N1E-115) were studied." | 3.67 | Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells. ( el-Fakahany, EE; Lai, WS, 1987) |
| "Mouse N1E-115 neuroblastoma cells were used to study carbachol induced changes in muscarinic cholinergic parameters." | 3.67 | Exposure to carbachol induces several changes in muscarinic cholinergic parameters in N1E-115 mouse neuroblastoma cells. ( Hedlund, B; Lorentz, M; Reintam, AC; Sydbom, A, 1988) |
| "Effects of pertussis toxin or cholera toxin on carbachol-stimulated inositol-1-phosphate ([3H]IP1) accumulation were studied using the human neuroblastoma cell line (SH-SY5Y)." | 3.67 | Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin. ( Mei, L; Roeske, WR; Yamamura, HI, 1988) |
| "The binding characteristics of [3H]phorbol-12,13-dibutyrate ([3H]PDBu) in mouse neuroblastoma N1E-115 cells were studied." | 3.67 | Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function. ( el-Fakahany, EE; Lai, WS, 1988) |
| "Incubation of mouse neuroblastoma cells (clone N1E-115) with Mn2+ resulted in a rapid and transient increase in cyclic GMP formation." | 3.66 | Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells. ( El-Fakahany, E; Richelson, E, 1980) |
| "Incubation of neuroblastoma NIE 115 cells with veratrine leads to an apparent reduction in the number of muscarinic acetylcholine receptors assayed by [3H]scopolamine methyl chloride binding." | 3.66 | The effect of sodium channel activators on muscarinic receptors of neuroblastoma cells. ( Milligan, G; Strange, PG, 1982) |
| "Several calcium antagonists were screened for their effect on muscarinic acetylcholine receptor-mediated cyclic GMP formation in murine neuroblastoma cells (clone N1E-115)." | 3.66 | Effect of some calcium antagonists on muscarinic receptor-mediated cyclic GMP formation. ( El-Fakahany, E; Richelson, E, 1983) |
| "The cholinergic agonist carbachol, epinephrine, and the opiate morphine all inhibit prostaglandin E1 (PGE1)-stimulated adenylate cyclase in homogenates from the neuroblastoma-glioma hybrid NG108-15." | 3.66 | Specific muscarinic-cholinergic desensitization in the neuroblastoma-glioma hybrid NG108-15. ( Clark, RB; Green, DA, 1982) |
| "Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells." | 3.66 | Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells. ( Richelson, E, 1978) |
| "The increase in intracellular cyclic GMP concentrations in response to muscarinic-receptor activation in N1E-115 neuroblastoma cells is dependent on extracellular Ca2+ ion." | 3.66 | Regulation of synthesis of guanosine 3':5'-cyclic monophosphate in neuroblastoma cells. ( Bartfai, T; Breakefield, XO; Greengard, P, 1978) |
| "A convenient, inexpensive assay was developed for measuring relative changes in cyclic GMP in whole mouse neuroblastoma cells (clone NIE 115) based on labelling the cellular GTP pool with [8(-3)H]guanine." | 3.66 | A method for measuring relative changes in guanosine 3':5'-cyclic monophosphate in mouse neuroblastoma cells on muscarinic cholinergic stimulation. ( Strange, PG, 1978) |
| "Further, treatment of human neuroblastoma SH-SY5Y cells with retinoic acid results in the cells withdrawing from the cell cycle and extending neurites, in the same time frame that tissue transglutaminase expression significantly increases." | 1.31 | Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells. ( Johnson, GV; Lesort, M; Tucholski, J, 2001) |
| "That carbachol can activate src family kinases was indicated further by the finding that carbachol induced an increase in tyrosine phosphorylation of p120-src substrate, which was inhibited by PP1." | 1.30 | Oxidative stress oppositely modulates protein tyrosine phosphorylation stimulated by muscarinic G protein-coupled and epidermal growth factor receptors. ( Grimes, CA; Jope, RS; Song, L; Zhang, L, 1999) |
| " These toxic effects did not occur in the dark or after preincubation with the antioxidant alpha-tocopherol." | 1.29 | Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism. ( Mathes, C; Thompson, SH; Wang, SS, 1993) |
| " These toxic effects did not occur in the dark or after preincubation with the antioxidant alpha-tocopherol." | 1.29 | Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism. ( Mathes, C; Thompson, SH; Wang, SS, 1993) |
| " Interpolating from the dose-response curve taken before desensitization, this is equivalent to an average 23% reduction in the number of muscarinic receptors." | 1.29 | Measurement of changes in functional muscarinic acetylcholine receptor density in single neuroblastoma cells using calcium release kinetics. ( Thompson, SH; Wang, SS, 1994) |
| "Carbachol did, however, cause a gradual increase in immunoreactive zeta-PKC which reached maximal values 10-20 min after stimulation." | 1.29 | Muscarinic receptor-mediated increase in zeta-PKC expression in SK-N-SH human neuroblastoma cells. ( Baumgold, J; Dyer, KD, 1994) |
| "Carbachol-pretreated SH-SY5Y cells (1 mM, > or 6 hr) exhibit a decrease in Ins(1,4,5)P3 receptor number, accompanied by both a rightward shift and a reduced maximal Ca2+ release in their Ins(1,4,5)P3 concentration-response curve." | 1.29 | Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells. ( Challiss, RA; Liu, C; Nahorski, SR; Potter, BV; Wilcox, RA, 1993) |
| " The dose-response curve for this suppression was very similar to that for stimulation of inositol monophosphate (IP1) formation and for stimulation of the initial rise of [Ca2+]i elicited by carbachol." | 1.28 | Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells. ( Nakagawa-Yagi, Y; Nakamura, H; Saito, Y; Takada, Y, 1992) |
| " The dose-response relations of carbachol-induced cAMP synthesis and carbachol-induced rise in intracellular free Ca2+ were similar." | 1.28 | Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C. ( Akerman, KE; Jansson, CC; Kukkonen, J, 1991) |
| "Pretreatment with carbachol for 30 hr led to an enhanced cAMP response which decayed in two components, a rapid component and an additional, more stable component which persisted for at least 2 hr after withdrawal of carbachol." | 1.28 | Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation. ( Hoffman, BB; Thomas, JM, 1990) |
| "Carbachol-stimulated increase in [Ca2+]i was blocked by atropine and Ni2+ but was totally resistant to the L- and N-channel blockers." | 1.28 | Different mechanisms of Ca2+ entry induced by depolarization and muscarinic receptor stimulation in SH-SY5Y human neuroblastoma cells. ( Baird, JG; Lambert, DG; Nahorski, SR; Whitham, EM, 1990) |
| " Guanosine 5'-[gamma-thio]triphosphate enhanced the maximal effect and the potency of carbachol on Ca2+ mobilization and InsP3 mass, but caused separation of the dose-response curves (EC50 = 0." | 1.28 | Coupling of muscarinic receptors to the mobilization of intracellular Ca2+ stores in permeabilized SH-SY5Y human neuroblastoma cells. ( Challiss, RA; Nahorski, SR; Safrany, ST; Strupish, J; Wojcikiewicz, RJ, 1990) |
| " In the presence of both antagonists, a supraadditive shift in the carbamylcholine dose-response curve was demonstrated for the two responses, a result suggestive of an allosteric mode of interaction between gallamine and NMS binding sites." | 1.28 | Mixed competitive and allosteric antagonism by gallamine of muscarinic receptor-mediated second messenger responses in N1E-115 neuroblastoma cells. ( el-Fakahany, EE; Lee, NH, 1989) |
| "Carbachol treatment of cells resulted in down-regulation of muscarinic cholinergic receptors to 45." | 1.27 | Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. ( Hoffman, BB; Thomas, JM, 1986) |
| " Incubation of cells with pertussis toxin, however, did not significantly alter the dose-response curve for carbamylcholine effects on cGMP." | 1.27 | Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells. ( Bruni, P; Burns, DL; Hewlett, EL; Moss, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 79 (30.15) | 18.7374 |
| 1990's | 154 (58.78) | 18.2507 |
| 2000's | 26 (9.92) | 29.6817 |
| 2010's | 3 (1.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edelstein, J | 1 |
| Hao, T | 1 |
| Cao, Q | 1 |
| Morales, L | 1 |
| Rockwell, P | 1 |
| Uwada, J | 1 |
| Anisuzzaman, AS | 1 |
| Nishimune, A | 1 |
| Yoshiki, H | 1 |
| Muramatsu, I | 1 |
| Lu, J | 1 |
| E, L | 1 |
| Roy, N | 1 |
| Hutfles, L | 1 |
| Selfridge, E | 1 |
| Funk, E | 1 |
| Burns, JM | 1 |
| Swerdlow, RH | 1 |
| Greenwood, JM | 1 |
| Dragunow, M | 1 |
| Van Acker, K | 2 |
| Nadif Kasri, N | 1 |
| De Smet, P | 2 |
| Parys, JB | 2 |
| De Smedt, H | 2 |
| Missiaen, L | 2 |
| Callewaert, G | 2 |
| Cheng, G | 1 |
| Iijima, Y | 1 |
| Ishibashi, Y | 1 |
| Kuppuswamy, D | 1 |
| Cooper, G | 1 |
| Racchi, M | 4 |
| Mazzucchelli, M | 2 |
| Pascale, A | 1 |
| Sironi, M | 3 |
| Govoni, S | 4 |
| Nordin-Andersson, M | 1 |
| Walum, E | 1 |
| Kjellstrand, P | 1 |
| Forsby, A | 1 |
| Garavito-Aguilar, ZV | 1 |
| Recio-Pinto, E | 1 |
| Corrales, AV | 1 |
| Zhang, J | 1 |
| Blanck, TJ | 1 |
| Xu, F | 1 |
| Lanni, C | 1 |
| Porrello, E | 1 |
| Zimmermann, M | 1 |
| Gardoni, F | 1 |
| Marcello, E | 1 |
| Colciaghi, F | 1 |
| Borroni, B | 1 |
| Padovani, A | 1 |
| Cattabeni, F | 1 |
| Di Luca, M | 1 |
| Serù, R | 1 |
| Mondola, P | 1 |
| Damiano, S | 1 |
| Svegliati, S | 1 |
| Agnese, S | 1 |
| Avvedimento, EV | 1 |
| Santillo, M | 1 |
| Cuadra, AE | 2 |
| El-Fakahany, EE | 13 |
| Kersanté, F | 1 |
| Mollereau, C | 1 |
| Zajac, JM | 1 |
| Roumy, M | 1 |
| King, TD | 1 |
| Song, L | 6 |
| Jope, RS | 9 |
| Fisk, L | 1 |
| Nalivaeva, NN | 1 |
| Turner, AJ | 1 |
| Schliebs, R | 1 |
| Heidel, K | 1 |
| Apelt, J | 1 |
| Gniezdzinska, M | 1 |
| Kirazov, L | 1 |
| Szutowicz, A | 1 |
| Rössler, OG | 1 |
| Henss, I | 1 |
| Thiel, G | 1 |
| Dozio, E | 1 |
| Ruscica, M | 1 |
| Feltrin, D | 1 |
| Motta, M | 2 |
| Magni, P | 2 |
| Howlett, AC | 4 |
| Wüster, M | 1 |
| Costa, T | 1 |
| Tank, AW | 1 |
| Weiner, N | 1 |
| McKinney, M | 5 |
| Stenstrom, S | 3 |
| Richelson, E | 18 |
| El-Fakahany, E | 5 |
| Wastek, GJ | 1 |
| Lopez, JR | 2 |
| Milligan, G | 2 |
| Strange, PG | 4 |
| Ohsako, S | 1 |
| Deguchi, T | 2 |
| Feigenbaum, P | 2 |
| Cohen, NM | 1 |
| Schmidt, DM | 1 |
| McGlennen, RC | 1 |
| Klein, WL | 2 |
| Maloteaux, JM | 1 |
| Gossuin, A | 1 |
| Pauwels, PJ | 1 |
| Laduron, PM | 1 |
| Green, DA | 1 |
| Clark, RB | 1 |
| Shifrin, GS | 1 |
| Thomas, JM | 4 |
| Frazier, JS | 1 |
| Hu, ZW | 1 |
| Hoffman, BB | 4 |
| Hescheler, J | 1 |
| Suh, BC | 3 |
| Kim, KT | 3 |
| Vaughan, PF | 10 |
| Kaye, DF | 1 |
| Ball, SG | 8 |
| Reeve, HL | 1 |
| Peers, C | 2 |
| Willars, GB | 4 |
| Nahorski, SR | 21 |
| Rösner, H | 1 |
| Vacun, G | 1 |
| Rebhan, M | 1 |
| Larsson, C | 7 |
| Simonsson, P | 4 |
| Hoek, JB | 1 |
| Alling, C | 7 |
| Tai, S | 1 |
| Kaji, H | 1 |
| Okimura, Y | 1 |
| Abe, H | 1 |
| Chihara, K | 1 |
| Offermanns, S | 1 |
| Bombien, E | 1 |
| Schultz, G | 1 |
| Wang, SS | 5 |
| Mathes, C | 5 |
| Thompson, SH | 9 |
| Purkiss, JR | 1 |
| Alousi, AA | 1 |
| Lambert, DG | 22 |
| Hirst, RA | 5 |
| Cembala, TM | 1 |
| Frost, CL | 1 |
| Atcheson, R | 5 |
| Smart, D | 5 |
| Smith, G | 5 |
| Shintani, F | 1 |
| Kanba, S | 5 |
| Nakaki, T | 2 |
| Nakamura, R | 1 |
| Sato, K | 1 |
| Yagi, G | 1 |
| Kato, R | 2 |
| Asai, M | 1 |
| Lenz, W | 1 |
| Petrusch, C | 1 |
| Jakobs, KH | 1 |
| van Koppen, CJ | 1 |
| Gustavsson, L | 2 |
| Bergman, O | 1 |
| Gray, DW | 1 |
| Challiss, RA | 7 |
| Safrany, ST | 3 |
| Rowbotham, DJ | 4 |
| Coggan, JS | 2 |
| Kovacs, I | 1 |
| Ehrich, M | 1 |
| Intropido, L | 1 |
| Costa, LG | 1 |
| Piiper, A | 1 |
| Stryjek-Kaminska, D | 1 |
| Zeuzem, S | 1 |
| Hu, J | 1 |
| Willets, JM | 2 |
| Griffiths, HR | 1 |
| Wojcikiewicz, RJ | 8 |
| Furuichi, T | 1 |
| Nakade, S | 2 |
| Mikoshiba, K | 2 |
| Philp, RB | 2 |
| Kalogeros, G | 2 |
| McIver, DJ | 1 |
| Dixon, SJ | 1 |
| Baumgold, J | 3 |
| Dyer, KD | 1 |
| Turner, NA | 3 |
| Walker, JH | 4 |
| Wilcox, RA | 1 |
| Liu, C | 1 |
| Potter, BV | 2 |
| Stuhlmüller, B | 1 |
| Kalden, JR | 1 |
| Fahlbusch, R | 1 |
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| Rumsby, MG | 1 |
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| Stubbs, EB | 2 |
| Agranoff, BW | 4 |
| Murphy, MG | 1 |
| Yorek, MA | 1 |
| Davidson, EP | 1 |
| Dunlap, JA | 1 |
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| Resendes, MC | 1 |
| Stuart, JA | 1 |
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| Marinovich, M | 1 |
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| Lin, WW | 1 |
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| Farlow, MR | 2 |
| Allouche, S | 1 |
| Polastron, J | 1 |
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| Chien, CC | 1 |
| Standifer, KM | 1 |
| Pasternak, GW | 1 |
| Cattaneo, MG | 1 |
| Amoroso, D | 1 |
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| Ding, W | 1 |
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| Lundqvist, C | 1 |
| Puhl, HL | 1 |
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| Williams, CL | 1 |
| Aronstam, RS | 1 |
| McDonald, RL | 1 |
| Roberts, DJ | 1 |
| Palmer, AC | 1 |
| Ding, WQ | 2 |
| Roberts, RE | 1 |
| Marsden, CA | 1 |
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| Bjornstrom, K | 1 |
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4 reviews available for carbachol and Neuroblastoma
| Article | Year |
|---|---|
The opioid-induced desensitization (tolerance) in neuroblastoma x glioma NG 108-15 hybrid cells: results from receptor uncoupling.
Topics: Animals; Bacterial Toxins; Carbachol; Cell Membrane; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine | 1984 |
Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route?
Topics: Calcium; Calcium Channels; Carbachol; Electrophysiology; GTP-Binding Proteins; Humans; Inositol Phos | 1992 |
Neuronal muscarinic receptors and phosphoinositide metabolism.
Topics: Animals; Brain; Calcium; Carbachol; Cell Line; Homeostasis; Humans; Inositol Phosphates; Models, Neu | 1991 |
Second-messenger responses associated with stimulation of neuronal muscarinic receptors expressed by a human neuroblastoma SH-SY5Y.
Topics: Calcium; Carbachol; Cell Line; Humans; Models, Neurological; Neuroblastoma; Neurons; Phosphatidylino | 1990 |
258 other studies available for carbachol and Neuroblastoma
| Article | Year |
|---|---|
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells.
Topics: Apoptosis; Carbachol; Cell Line, Tumor; Culture Media, Serum-Free; Humans; Neuroblastoma; Neurons; O | 2011 |
Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells.
Topics: Animals; Atropine; Blotting, Western; Calcium; Carbachol; Cell Line, Tumor; Elapid Venoms; Enzyme Ac | 2011 |
Effect of cholinergic signaling on neuronal cell bioenergetics.
Topics: Acetylcholine; Carbachol; Cell Line, Tumor; Cholinergic Agonists; Energy Metabolism; Glycolysis; Hum | 2013 |
Muscarinic receptor-mediated phosphorylation of cyclic AMP response element binding protein in human neuroblastoma cells.
Topics: Atropine; Blotting, Western; Carbachol; Cholinergic Agonists; Cyclic AMP Response Element-Binding Pr | 2002 |
IP(3)-mediated Ca(2+) signals in human neuroblastoma SH-SY5Y cells with exogenous overexpression of type 3 IP(3) receptor.
Topics: Binding Sites; Calcium; Calcium Channels; Calcium Signaling; Carbachol; Cell Division; Cholinergic A | 2002 |
Inhibition of G protein-coupled receptor trafficking in neuroblastoma cells by MAP 4 decoration of microtubules.
Topics: Actin Cytoskeleton; Animals; Carbachol; Cell Membrane; Fluorescent Dyes; GTP-Binding Proteins; Mice; | 2002 |
Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein.
Topics: Amyloid beta-Protein Precursor; Carbachol; Carcinogens; Cholinergic Agents; Humans; Isoenzymes; Neur | 2003 |
Acrylamide-induced effects on general and neurospecific cellular functions during exposure and recovery.
Topics: Acrylamide; Calcium; Carbachol; Cell Count; Dose-Response Relationship, Drug; Humans; Neurites; Neur | 2003 |
Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells.
Topics: Atropine; Calcium; Carbachol; Cell Line, Tumor; Cholinergic Agonists; Dose-Response Relationship, Dr | 2004 |
Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein.
Topics: Amyloid beta-Protein Precursor; Animals; Biological Transport; Carbachol; Cell Line, Tumor; Choliner | 2004 |
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.
Topics: Acetylcholinesterase; ADAM Proteins; ADAM10 Protein; Amyloid beta-Peptides; Amyloid beta-Protein Pre | 2004 |
HaRas activates the NADPH oxidase complex in human neuroblastoma cells via extracellular signal-regulated kinase 1/2 pathway.
Topics: Amino Acid Substitution; Carbachol; Cell Line, Tumor; Cell Membrane; Cholinergic Agonists; Enzyme Ac | 2004 |
Mechanisms of M(1) muscarinic receptor-mediated up-regulation of neuronal nitric oxide synthase in N1E-115 neuroblastoma cells.
Topics: Analysis of Variance; Animals; Atropine; Blotting, Western; Carbachol; Cell Line, Tumor; Chelating A | 2005 |
Anti-opioid activities of NPFF1 receptors in a SH-SY5Y model.
Topics: Calcium Channels, N-Type; Carbachol; Cell Line, Tumor; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; | 2006 |
AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Carbachol; Cell Line, Tumor; Enzyme Activ | 2006 |
Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells.
Topics: Aspartic Acid Endopeptidases; Carbachol; Cell Hypoxia; Cell Line, Tumor; Cholinergic Agonists; Endot | 2006 |
Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Topics: Acetylcholinesterase; Alzheimer Disease; Carbachol; Cholinergic Agonists; Dose-Response Relationship | 2006 |
Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells.
Topics: Calcineurin; Carbachol; Cell Line, Tumor; DNA, Single-Stranded; Dual Specificity Phosphatase 1; ets- | 2008 |
Cholinergic regulation of neuropeptide Y synthesis and release in human neuroblastoma cells.
Topics: Carbachol; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Neuroblast | 2008 |
Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Alprostadil; Animals; Carbachol; C | 1984 |
Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Car | 1981 |
Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115). Selective loss with subculturing of the low-affinity agonist site mediating cyclic GMP formation.
Topics: Animals; Binding, Competitive; Bradykinin; Carbachol; Cell Line; Clone Cells; Cyclic GMP; Guanylate | 1984 |
Temperature dependence of muscarinic acetylcholine receptor activation, desensitization, and resensitization.
Topics: Acetylcholine; Animals; Carbachol; Clone Cells; Cyclic GMP; Mice; Neoplasms, Experimental; Neuroblas | 1980 |
Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells.
Topics: Animals; Calcium; Carbachol; Cells, Cultured; Cyclic GMP; Ion Channels; Manganese; Mice; Neuroblasto | 1980 |
Demonstration of a muscarinic receptor-mediated cyclic GMP-dependent hyperpolarization of the membrane potential of mouse neuroblastoma cells using [3H]tetraphenylphosphonium.
Topics: Animals; Carbachol; Cells, Cultured; Cyclic GMP; Kinetics; Membrane Potentials; Mice; Neoplasms, Exp | 1981 |
Phenoxybenzamine and dibenamine interactions with calcium channel effectors of the muscarinic receptor.
Topics: Animals; Binding, Competitive; Calcium; Carbachol; Cells, Cultured; Cyclic GMP; Dibenzylchlorethamin | 1981 |
The effect of sodium channel activators on muscarinic receptors of neuroblastoma cells.
Topics: Carbachol; Cell Line; Cells, Cultured; Ion Channels; Neuroblastoma; Receptors, Cholinergic; Receptor | 1982 |
Effect of some calcium antagonists on muscarinic receptor-mediated cyclic GMP formation.
Topics: Animals; Calcium; Carbachol; Cell Line; Cyclic GMP; Manganese; Mice; Neuroblastoma; Nickel; Quinucli | 1983 |
Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells.
Topics: Alprostadil; Biological Transport; Calcium; Carbachol; Cell Line; Cyclic GMP; Histamine; Ion Channel | 1984 |
Use of [3H]triphenylmethylphosphonium cation for estimating membrane potential in neuroblastoma cells.
Topics: Animals; Anions; Carbachol; Cations; Cell Line; Chemical Precipitation; Indicators and Reagents; Mem | 1984 |
Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells.
Topics: Animals; Carbachol; Clone Cells; Mice; N-Methylscopolamine; Neuroblastoma; Neurons; Receptors, Musca | 1984 |
Receptor-mediated increases in phosphatidylinositol turnover in neuron-like cell lines.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Line; Kinetics; Mice; Neuroblastoma; Neurons; Phos | 1983 |
Short-term disappearance of muscarinic cell surface receptors in carbachol-induced desensitization.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; Cerebellum; Glioma; Hybrid Cells; N-Methylscopolamine; | 1983 |
Lanthanum binding to murine neuroblastoma cells.
Topics: Animals; Atropine; Carbachol; Cell Line; Cell Membrane; Dibenzylchlorethamine; Electron Probe Microa | 1983 |
Specific muscarinic-cholinergic desensitization in the neuroblastoma-glioma hybrid NG108-15.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Atropine; Carbachol; Cell Line; Glioma; Hybrid Cells; Mice; | 1982 |
Regulation of muscarinic acetylcholine receptor concentration in cloned neuroblastoma cells.
Topics: Acetylcholine; Animals; Arecoline; Carbachol; Cell Line; Clone Cells; Dose-Response Relationship, Dr | 1980 |
Phosphorylation of cyclic AMP response element-binding protein and induction of c-fos gene expression on withdrawal from chronic treatment with carbachol in NG108-15 cells.
Topics: Alprostadil; Animals; Carbachol; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Gene Expre | 1995 |
Whole-cell clamp analysis for G-protein regulation of channels.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium Channels; Carbachol; Cholera Toxin; Electrophysiology | 1994 |
Inhibition of bradykinin-induced cytosolic Ca2+ elevation by muscarinic stimulation without attenuation of inositol 1,4,5-trisphosphate production in human neuroblastoma SK-N-BE(2)C cells.
Topics: Bradykinin; Calcium; Carbachol; Cytosol; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Membran | 1995 |
The effect of barium on [3H]noradrenalin release from the human neuroblastoma SH-SY5Y.
Topics: Barium; Calcium; Carbachol; Evoked Potentials; Exocytosis; Humans; Neuroblastoma; Neurons; Nifedipin | 1995 |
Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells.
Topics: Bradykinin; Calcium; Carbachol; Fura-2; Ganglia, Sympathetic; Humans; Inositol 1,4,5-Trisphosphate; | 1995 |
Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C.
Topics: Acetylcholine; Actins; Alkaloids; Carbachol; Cell Size; Culture Media; Cytochalasin B; Fluorescent D | 1995 |
Ethanol inhibits the peak of muscarinic receptor-stimulated formation of inositol 1,4,5-trisphosphate in neuroblastoma SH-SY5Y cells.
Topics: Carbachol; Ethanol; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Muscarinic Antagonists; Neurobla | 1995 |
Neurokinin receptor antagonists inhibit the binding of growth hormone-releasing peptide to EP-1 human neuroblastoma cells.
Topics: Alprostadil; Animals; Atropine; Carbachol; Cell Line; Growth Hormone-Releasing Hormone; Guanylyl Imi | 1995 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growt | 1993 |
Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism.
Topics: Animals; Calcium; Carbachol; Cell Line; Cell Membrane; Fluorescent Dyes; Free Radicals; Fura-2; Home | 1993 |
Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism.
Topics: Animals; Calcium; Carbachol; Free Radicals; Fura-2; Homeostasis; Membranes; Mice; Naphthalenes; Neur | 1993 |
Phospholipase D does not mediate alcohol inhibition of [3H]-noradrenaline release from SH-SY5Y cells.
Topics: Bradykinin; Butanols; Carbachol; Cell Line; Humans; Ionomycin; Kinetics; Methacholine Chloride; Neur | 1994 |
Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion?
Topics: Bradykinin; Calcium; Carbachol; Cell Adhesion; Drug Interactions; Humans; Inositol 1,4,5-Trisphospha | 1995 |
The lifetime of inositol 1,4,5-trisphosphate in single cells.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbachol; Cell Differentiation; Egtazic Acid; Eukar | 1995 |
Characterisation of a new human neuroblastoma cell line, NAL-GT.
Topics: Calcium; Carbachol; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Female; Humans; Infant; Morph | 1995 |
Stimulation of adenylyl cyclase mediated by phospholipase C-linked M3 muscarinic receptor in human neuroblastoma SK-N-BE (2) C cells.
Topics: Adenylyl Cyclases; Calcium; Carbachol; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Membranes | 1995 |
Adenylyl cyclase in SH-SY5Y human neuroblastoma cells is regulated by intra- and extracellular calcium.
Topics: Adenylyl Cyclases; Atropine; Calcium; Carbachol; Cell Line; Cyclic AMP; Humans; Muscarine; Neuroblas | 1995 |
Effects of propofol on cAMP and Ins(1,4,5)P3 formation and [3H]noradrenaline uptake and release from SH-SY5Y cells.
Topics: Biological Transport, Active; Carbachol; Cyclic AMP; Humans; Inositol 1,4,5-Trisphosphate; Neuroblas | 1994 |
Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening.
Topics: Calcium; Calcium Channels; Carbachol; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activatio | 1995 |
Inhibition by lithium of cyclic GMP formation without inhibition of nitric oxide generation in the mouse neuroblastoma cell (N1E-115).
Topics: Animals; Arginine; Brain Neoplasms; Carbachol; Cyclic GMP; Guanylate Cyclase; Lithium; Mice; Muscari | 1994 |
Agonist-induced down-regulation of the m4 muscarinic acetylcholine receptor occurs without changes in receptor mRNA steady-state levels.
Topics: Animals; Carbachol; Cell Line; Cycloheximide; Dactinomycin; Down-Regulation; Kinetics; Mice; Muscari | 1994 |
Mechanisms of muscarinic receptor-stimulated expression of c-fos in SH-SY5Y cells.
Topics: Carbachol; Diglycerides; Ethers, Cyclic; Gene Expression Regulation; Genes, fos; Humans; Neuroblasto | 1994 |
Differential effects of lithium on muscarinic cholinoceptor-stimulated CMP-phosphatidate accumulation in cerebellar granule cells, CHO-M3 cells, and SH-SY5Y neuroblastoma cells.
Topics: Animals; Animals, Newborn; Carbachol; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cytidine M | 1994 |
Calcium current activated by muscarinic receptors and thapsigargin in neuronal cells.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbachol; Egtazic Acid; Ion Channel Gating; Mice; M | 1994 |
A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells.
Topics: Arecoline; Brain Neoplasms; Calcium; Calcium Radioisotopes; Carbachol; Guanine Nucleotides; Humans; | 1994 |
Studies on the mechanism of [3H]-noradrenaline release from SH-SY5Y cells: the role of Ca2+ and cyclic AMP.
Topics: Calcium; Calcium Channel Blockers; Carbachol; Cyclic AMP; Humans; Kinetics; Models, Biological; Neur | 1994 |
The aminoglycoside G418 suppresses muscarinic receptor-activated calcium release in stably transfected murine N1E-115 neuroblastoma cells.
Topics: Animals; Bradykinin; Calcium; Carbachol; Gentamicins; Histamine; Mice; Neuroblastoma; Osmolar Concen | 1994 |
Interaction of organophosphorus compounds with muscarinic receptors in SH-SY5Y human neuroblastoma cells.
Topics: Carbachol; Humans; Inositol Phosphates; Insecticides; Isoflurophate; Neuroblastoma; Organophosphorus | 1994 |
Measurement of changes in functional muscarinic acetylcholine receptor density in single neuroblastoma cells using calcium release kinetics.
Topics: Animals; Calcium; Carbachol; Fura-2; Histamine; Kinetics; Mice; Neuroblastoma; Receptors, Histamine | 1994 |
Synthetic Rab3A effector domain peptide stimulates inositol 1,4,5-trisphosphate production in various permeabilized cells.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Bombesin; Carbachol; Cell Membrane Permeability; Digitonin; | 1994 |
Role of intercellular and intracellular communication by nitric oxide in coupling of muscarinic receptors to activation of guanylate cyclase in neuronal cells.
Topics: Alkylation; Animals; Carbachol; Cell Communication; Cyclic GMP; Enzyme Activation; Guanylate Cyclase | 1993 |
Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells.
Topics: Atropine; Carbachol; Cell Differentiation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePh | 1994 |
Carbachol stimulated cAMP formation in SH-SY5Y cells is dependent on both extracellular and intracellular calcium.
Topics: Adenylyl Cyclases; Analysis of Variance; Calcium; Carbachol; Cell Line; Cell Membrane; Cyclic AMP; H | 1993 |
Suitability of B65 and SH-SY5Y neuroblastoma cells as models for 'in vitro' neurotoxicity testing.
Topics: Animals; Biological Transport; Carbachol; Cell Line; Dopamine; Drug Evaluation, Preclinical; Humans; | 1993 |
A dose-dependent enhancement of muscarinic activation of phospholipase C by halothane in SH-SY5Y cells.
Topics: Carbachol; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Halothane | 1993 |
Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation.
Topics: Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Carbachol; Cell Line; CHO Cells; C | 1994 |
Halothane and isoflurane enhance basal and carbachol-stimulated inositol(1,4,5)triphosphate formation in SH-SY5Y human neuroblastoma cells.
Topics: Carbachol; Halothane; Humans; Inositol 1,4,5-Trisphosphate; Isoflurane; Neuroblastoma; Neurons; Tumo | 1994 |
Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome.
Topics: Argon; Calcium; Carbachol; Helium; High Pressure Neurological Syndrome; Humans; Neuroblastoma; Nitro | 1994 |
Muscarinic receptor-mediated increase in zeta-PKC expression in SK-N-SH human neuroblastoma cells.
Topics: Blotting, Western; Carbachol; Enzyme Activation; Humans; Isoenzymes; Neuroblastoma; Phorbol Esters; | 1994 |
Protein kinase C subtypes associated with the regulation of noradrenaline release in human SH-SY5Y neuroblastoma cells.
Topics: Carbachol; Cell Line; Humans; Indoles; Isoenzymes; Kinetics; Maleimides; Neuroblastoma; Norepinephri | 1993 |
Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells.
Topics: Calcium; Calcium Channels; Carbachol; Cell Membrane Permeability; Chromatography, High Pressure Liqu | 1993 |
Immunological and functional properties of the acetylcholine receptor expressed on the human cell line TE671.
Topics: Autoantibodies; Bungarotoxins; Calcium; Carbachol; Carrier Proteins; Cells, Cultured; Chromatography | 1993 |
A role for protein kinase C subtypes alpha and epsilon in phorbol-ester-enhanced K(+)- and carbachol-evoked noradrenaline release from the human neuroblastoma SH-SY5Y.
Topics: Base Sequence; Blotting, Western; Carbachol; DNA Primers; Genes; Humans; Indoles; Maleimides; Molecu | 1994 |
Whole-cell recording of neuroblastoma x glioma cells during downregulation of a major substrate, 80K/MARCKS, of protein kinase C.
Topics: Animals; Carbachol; Cell Differentiation; Down-Regulation; Electrophysiology; Glioma; Hybrid Cells; | 1993 |
Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells.
Topics: Atropine; Carbachol; Cytidine Diphosphate Diglycerides; Humans; Inositol; Kinetics; Lithium; Neurobl | 1993 |
Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y.
Topics: Arachidonic Acid; Calcimycin; Carbachol; Cyclohexanones; Eicosanoids; Exocytosis; Humans; Linoleic A | 1993 |
Effect of bradykinin on cytosolic calcium in neuroblastoma cells using the fluorescent indicator fluo-3.
Topics: Aniline Compounds; Animals; Bradykinin; Calcium; Carbachol; Cytosol; Fluorescent Dyes; Mice; Neurobl | 1993 |
The relationship between depletion of intracellular Ca2+ stores and activation of Ca2+ current by muscarinic receptors in neuroblastoma cells.
Topics: Animals; Calcium; Calcium Channels; Carbachol; Chelating Agents; Egtazic Acid; Electrophysiology; En | 1995 |
Pressure antagonism of nitrous oxide depression of intracellular calcium in a neuroblastoma cell line.
Topics: Anesthetics, Inhalation; Atmospheric Pressure; Calcium; Carbachol; Helium; Humans; Neuroblastoma; Ni | 1996 |
Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbachol; Cell Line; CHO Cells; Cricetinae; Cytosol | 1996 |
Is actin polymerization relevant to neurosecretion? A study on neuroblastoma cells.
Topics: Actins; Carbachol; Cell Differentiation; Cell Line; Humans; Kinetics; Neuroblastoma; Norepinephrine; | 1996 |
Effects of propofol and thiopentone on potassium- and carbachol-evoked [3H]noradrenaline release and increased [Ca2+]i from SH-SY5Y human neuroblastoma cells.
Topics: Calcium; Carbachol; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Neuroblastoma; Norepi | 1996 |
Carbachol but not bradykinin blocks the enkephalin-induced calcium transient in human neuroblastoma SK-N-SH cells.
Topics: Bradykinin; Calcium; Carbachol; Cells, Cultured; Enkephalins; Humans; Inositol 1,4,5-Trisphosphate; | 1995 |
The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line.
Topics: Amino Acid Sequence; Calcium; Calcium Channel Blockers; Carbachol; Enzyme Inhibitors; Humans; Molecu | 1996 |
Carbachol inhibits insulin-stimulated phosphatidylinositol 3-kinase activity in SH-SY5Y neuroblastoma cells.
Topics: Carbachol; Cytidine Diphosphate Diglycerides; Humans; Insulin; Nerve Growth Factors; Neuroblastoma; | 1996 |
Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells.
Topics: Carbachol; Cells, Cultured; Dose-Response Relationship, Drug; Ethanol; Humans; Neuroblastoma; Recept | 1996 |
Determinants of the stimulatory opioid effect on intracellular calcium in SK-N-SH and NG108-15 neuroblastoma.
Topics: Bradykinin; Calcium; Carbachol; Cell Differentiation; Drug Synergism; Etorphine; Fura-2; Intracellul | 1996 |
Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis.
Topics: Carbachol; Cell Membrane; DNA; Enzyme Activation; Humans; Hydrogen Peroxide; Hydrolysis; Muscarinic | 1996 |
SK & F 96365 inhibits carbachol-induced phosphoinositide turnover in human neuroblastoma SH-SY5Y and rat cerebellar granule cells.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Carbachol; Cells, Cultured; Cerebellum; Cyt | 1996 |
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines.
Topics: Amyloid beta-Protein Precursor; Animals; Arecoline; Astrocytes; Atropine; Calcimycin; Carbachol; Cho | 1996 |
The effect of down-regulation and long-term inhibition of protein kinase C on noradrenaline secretion in the neuroblastoma cell line SH-SY5Y.
Topics: Calcimycin; Carbachol; Down-Regulation; Enzyme Inhibitors; Humans; Indoles; Maleimides; Neuroblastom | 1996 |
The delta-opioid receptor regulates activity of ryanodine receptors in the human neuroblastoma cell line SK-N-BE.
Topics: Calcium; Calcium Channels; Calmodulin-Binding Proteins; Carbachol; Enzyme Inhibitors; GTP-Binding Pr | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol | 1996 |
A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines.
Topics: Antineoplastic Agents; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carcinoma, | 1996 |
Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells.
Topics: Adenylyl Cyclases; Carbachol; Cells, Cultured; Cyclic AMP; Drug Synergism; Enzyme Activation; Estren | 1996 |
Phosphoinositide-derived diacylglycerol conversion to phosphatidic acid is a receptor-dependent and compartmentalized phenomenon in human neuroblastoma.
Topics: Carbachol; Diglycerides; Humans; Muscarinic Agonists; Neuroblastoma; Phosphatidic Acids; Phosphatidy | 1996 |
Muscarinic receptor-stimulated expression of c-fos in neuroblastoma cells.
Topics: Carbachol; Diglycerides; Ethanol; Gene Expression; Genes, fos; Humans; Inositol 1,4,5-Trisphosphate; | 1994 |
Arginine-modulated receptor-activated calcium influx via a NO/cyclic GMP pathway in human SK-N-SH neuroblastoma cells.
Topics: Arginine; Calcium; Carbachol; Cyclic GMP; Diffusion; Humans; Intracellular Membranes; Muscarinic Ago | 1997 |
Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells.
Topics: Brain Neoplasms; Calcium; Calcium Channels; Carbachol; Electrophysiology; Humans; Inosine Triphospha | 1997 |
On the role of agonist-evoked Ca2+ mobilization in sustaining the ongoing phosphoinositide hydrolysis. A study on intact SK-N-BE(2) neuroblastoma cells subjected to muscarinic stimulation.
Topics: Calcium; Calcium Channel Agonists; Carbachol; Chelating Agents; Egtazic Acid; Electrophysiology; Hum | 1997 |
Cholinergic-induced production of reactive oxygen species in human neuroblastoma cells.
Topics: Biological Transport; Calcium; Carbachol; Humans; Muscarinic Agonists; Neuroblastoma; Phorbol 12,13- | 1997 |
Characterization of phospholipase D activation by muscarinic receptors in human neuroblastoma SH-SY5Y cells.
Topics: Carbachol; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Neuroblastoma; Phospholipase D | 1997 |
Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpipe
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases | 1997 |
Regulation of [Ca++]i in human neuroblastoma (SH-SY5Y) cells expressing recombinant rat angiotensin1A receptors by angiotensin II and carbachol.
Topics: Angiotensin II; Animals; Calcium; Carbachol; Cells, Cultured; Humans; Neuroblastoma; Rats; Receptors | 1997 |
Effects of ethanol on muscarinic receptor-stimulated c-fos expression in human neuroblastoma cells.
Topics: Carbachol; Dose-Response Relationship, Drug; Enzyme Activation; Ethanol; Gene Expression Regulation; | 1997 |
Cholinergic modulation of the Ca2+ response to bradykinin in neuroblastoma cells.
Topics: Animals; Bradykinin; Calcium; Carbachol; Cholinergic Agonists; Mice; Muscarinic Agonists; Neuroblast | 1997 |
Studies of inositol phosphate export from neuronal tissue in vitro.
Topics: Animals; Carbachol; Cerebral Cortex; Hippocampus; Humans; In Vitro Techniques; Inositol; Inositol 1, | 1997 |
Effect of halothane on K+ and carbachol stimulated [3H]noradrenaline release and increased [Ca2+]i in SH-SY5Y human neuroblastoma cells.
Topics: Anesthetics, Inhalation; Calcium; Carbachol; Dose-Response Relationship, Drug; Halothane; Humans; Ne | 1997 |
Neurotransmitters activate the human estrogen receptor in a neuroblastoma cell line.
Topics: Adenoviridae; Benzazepines; Carbachol; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enzyme Inhibi | 1997 |
Etomidate inhibits [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells.
Topics: Calcium; Carbachol; Dose-Response Relationship, Drug; Etomidate; Humans; Neuroblastoma; Norepinephri | 1997 |
AP-1 and NF-kappaB stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium.
Topics: Carbachol; Humans; Lithium; Muscarinic Agonists; Neuroblastoma; Neurons; NF-kappa B; Signal Transduc | 1997 |
Cytosolic calmodulin is increased in SK-N-SH human neuroblastoma cells due to release of calcium from intracellular stores.
Topics: Calcium; Calmodulin; Carbachol; Chelating Agents; Cytosol; Egtazic Acid; Extracellular Space; Humans | 1998 |
Cholinergic regulation of VIP gene expression in human neuroblastoma cells.
Topics: Brain Neoplasms; Carbachol; Cycloheximide; Gene Expression Regulation, Neoplastic; Humans; Inositol | 1997 |
Glutathione depletion exacerbates impairment by oxidative stress of phosphoinositide hydrolysis, AP-1, and NF-kappaB activation by cholinergic stimulation.
Topics: Analysis of Variance; Base Sequence; Binding Sites; Buthionine Sulfoximine; Carbachol; Consensus Seq | 1998 |
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.
Topics: Androstadienes; Atropine; Carbachol; Cations, Monovalent; Chromones; Dose-Response Relationship, Dru | 1998 |
Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Calcium Channels; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP | 1998 |
Ethanol exposure potentiates fosB and junB expression induced by muscarinic receptor stimulation in neuroblastoma SH-SY5Y cells.
Topics: Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gene Expression; Humans; In | 1998 |
Involvement of receptor cycling and receptor reserve in resensitization of muscarinic responses in SH-SY5Y human neuroblastoma cells.
Topics: Calcium; Carbachol; Humans; Intracellular Membranes; Muscarinic Agonists; Neuroblastoma; Osmolar Con | 1998 |
The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line.
Topics: Arecoline; Bethanechol; Carbachol; Endocytosis; Humans; Kinetics; Ligands; Methacholine Chloride; Mu | 1998 |
Cholinergic muscarinic mechanisms regulate neuropeptide Y gene expression via protein kinase C in human neuroblastoma cells.
Topics: Carbachol; Dactinomycin; Gene Expression Regulation; Humans; Muscarinic Agonists; Neuroblastoma; Neu | 1998 |
A small cell lung carcinoma line and subclone expressing nicotinic acetylcholine receptors of muscle and neuronal types.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Calcium; Carbachol; Carcinoma, Small Cell; C | 1998 |
Up-regulation of the neuronal form of nitric oxide synthase in response to prolonged muscarinic M1 receptor stimulation.
Topics: Animals; Arginine; Binding, Competitive; Calcium; Carbachol; CHO Cells; Citrulline; Cricetinae; Dose | 1998 |
Comparative desensitization of the human 5-HT2A and 5-HT2C receptors expressed in the human neuroblastoma cell line SH-SY5Y.
Topics: Carbachol; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Neuroblastoma; Receptors, | 1998 |
Redistribution of F-actin and large dense-cored vesicles in the human neuroblastoma SH-SY5Y in response to secretagogues and protein kinase Calpha activation.
Topics: Actins; Calcimycin; Carbachol; Cell Membrane; Down-Regulation; Enzyme Activation; Humans; Ionophores | 1999 |
Muscarinic M3 and epidermal growth factor receptors activate mutually inhibitory signaling cascades in human neuroblastoma SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Carbachol; Cell Adhesio | 1999 |
Regulation of muscarinic receptor expression by changes in mRNA stability.
Topics: 3' Untranslated Regions; Animals; Base Sequence; Carbachol; CHO Cells; Cricetinae; Down-Regulation; | 1995 |
Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Blotting, No | 1999 |
Melatonin affects the metabolism of the beta-amyloid precursor protein in different cell types.
Topics: Amyloid beta-Protein Precursor; Animals; Carbachol; Cell Line; Culture Media, Conditioned; Dose-Resp | 1999 |
Oxidative stress oppositely modulates protein tyrosine phosphorylation stimulated by muscarinic G protein-coupled and epidermal growth factor receptors.
Topics: Carbachol; Cell Adhesion Molecules; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Facto | 1999 |
Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals | 1999 |
Influence of atropine on carbachol dual effect on Ca2+ mobilization in SH-SY5Y neuroblastoma cells.
Topics: Atropine; Calcium; Carbachol; Cholinergic Agents; Dose-Response Relationship, Drug; Humans; Kinetics | 1999 |
Human A-type ANP receptor upregulation by PACAP and carbachol in neuroblastoma cells.
Topics: Animals; Carbachol; Colforsin; Guanylate Cyclase; Humans; Neuroblastoma; Neuropeptides; Neurotransmi | 1999 |
Cholinergic stimulation of early growth response-1 DNA binding activity requires protein kinase C and mitogen-activated protein kinase kinase activation and is inhibited by sodium valproate in SH-SY5Y cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; DNA-Binding Proteins; DNA, Neoplasm; Early | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calc | 1999 |
Mapping of IP(3)-mediated Ca(2+) signals in single human neuroblastoma SH-SY5Y cells: cell volume shaping the Ca(2+) signal.
Topics: Caffeine; Calcium; Calcium Channels; Calcium Signaling; Carbachol; Cell Size; Central Nervous System | 2000 |
Muscarinic receptor activation promotes the membrane association of tubulin for the regulation of Gq-mediated phospholipase Cbeta(1) signaling.
Topics: Animals; Carbachol; Cell Membrane; Cholinergic Agonists; Cytoskeletal Proteins; GTP-Binding Protein | 2000 |
Mitochondrial DNA-depleted neuroblastoma (Rho degrees) cells exhibit altered calcium signaling.
Topics: Calcium; Calcium Signaling; Carbachol; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cytologic | 2000 |
Potentiation of carbachol-induced Ca2+ release by peroxynitrite in human neuroblastoma SH-SY5Y cells.
Topics: Calcium; Carbachol; Genistein; Humans; Molsidomine; Neuroblastoma; Nitrates; Phosphorylation; Tumor | 2000 |
Effects of ethanol on phosphoinositide hydrolysis and muscarinic acetylcholine receptor number in SH-SY5Y cells.
Topics: Binding Sites; Carbachol; Dose-Response Relationship, Drug; Ethanol; Humans; Hydrolysis; N-Methylsco | 2000 |
Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells.
Topics: Carbachol; Cell Differentiation; Gene Expression; Gene Silencing; GTP-Binding Proteins; Humans; Musc | 2001 |
Coincident signalling between the Gi/Go-coupled delta-opioid receptor and the Gq-coupled m3 muscarinic receptor at the level of intracellular free calcium in SH-SY5Y cells.
Topics: Animals; Calcium; Carbachol; CHO Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding | 2001 |
RGS2: regulation of expression and nuclear localization.
Topics: Carbachol; Cell Differentiation; Cell Line; Cell Nucleus; Cholinergic Agonists; Colforsin; Culture M | 2001 |
The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma.
Topics: Animals; Carbachol; Cell Differentiation; Cholinergic Agonists; Ganglioneuroblastoma; Humans; Immedi | 2001 |
Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein.
Topics: Acetylcholinesterase; Amyloid beta-Protein Precursor; Atropine; Carbachol; Cholinesterase Inhibitors | 2001 |
Antipsychotics block muscarinic acetylcholine receptor-mediated cyclic GMP formation in cultured mouse neuroblastoma cells.
Topics: Antipsychotic Agents; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Guanosine | 1977 |
Occupancy of muscarinic acetylcholine receptors stimulates a guanylate cyclase in neuroblastoma cells.
Topics: Acetylcholine; Atropine; Carbachol; Cell Line; Cell Membrane; Enzyme Activation; Guanylate Cyclase; | 1977 |
Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells.
Topics: Animals; Calcium; Carbachol; Cell Line; Cyclic GMP; Histamine; Histamine H1 Antagonists; Mice; Neuro | 1978 |
Regulation of synthesis of guanosine 3':5'-cyclic monophosphate in neuroblastoma cells.
Topics: Calcimycin; Calcium; Carbachol; Cell Line; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Kinetic | 1978 |
Effects of cholinergic agents and sodium ions on the levels of guanosine and adenosine 3':5'-cyclic monophosphates in neuroblastoma and neuroblastoma X glioma hybrid cells.
Topics: Acetylcholine; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interaction | 1975 |
Muscarinic regulation of cAMP in mouse neuroblastoma.
Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cells, Cultured; Cyclic AMP; Dose-Response Relationshi | 1977 |
Desensitisation of muscarinic receptor-mediated cyclic GMP formation by cultured nerve cells.
Topics: Acetylcholine; Animals; Carbachol; Cells, Cultured; Cyclic GMP; Depression, Chemical; Histamine; Mic | 1978 |
A method for measuring relative changes in guanosine 3':5'-cyclic monophosphate in mouse neuroblastoma cells on muscarinic cholinergic stimulation.
Topics: Carbachol; Cell Line; Chromatography; Cyclic GMP; Guanine; Methods; Neuroblastoma; Neurons | 1978 |
Effects of extracellular calcium ions on the elevation of guanosine 3',5'-monophosphate level in neuroblastoma cells.
Topics: Animals; Azides; Calcimycin; Calcium; Carbachol; Cyclic GMP; Egtazic Acid; Methylnitronitrosoguanidi | 1979 |
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenylyl Cyclase Inhibitors; Adenylyl | 1979 |
Phospholipid metabolism in cultured neuroblastoma and glioma cells incubated with carbamylcholine and norepinephrine.
Topics: Animals; Carbachol; Clone Cells; Glioma; Neoplasms, Experimental; Neuroblastoma; Norepinephrine; Pho | 1975 |
Muscarinic response to acetylcholine in neuroblastoma times glioma hybrid cells.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Clone Cells; Glioma; Hybrid Cells; Mice; Neuroblastoma; | 1975 |
The cholinergic agonist carbachol reduces intracellular beta-amyloid precursor protein in PC 12 and C6 cells.
Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Western; Carbachol; Heat-Shock Proteins; Neurobla | 1992 |
GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells.
Topics: Action Potentials; Animals; Calcium; Carbachol; Cell Membrane; Membrane Potentials; Mice; Neuroblast | 1992 |
Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells.
Topics: Atropine; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Colforsin; Cyclic AMP; Drug Inter | 1992 |
Calcium independence of phosphoinositide hydrolysis-induced increase in cyclic AMP accumulation in SK-N-SH human neuroblastoma cells.
Topics: Calcium; Carbachol; Cyclic AMP; Edetic Acid; Egtazic Acid; Humans; Hydrolysis; Inositol Phosphates; | 1992 |
Vanadate amplifies receptor-mediated accumulation of inositol trisphosphates and inhibits inositol tris- and tetrakis-phosphatase activities.
Topics: Animals; Carbachol; Cell Line; Clone Cells; Epidermal Growth Factor; Humans; Inositol 1,4,5-Trisphos | 1992 |
Distinct regulation of vasoactive intestinal peptide (VIP) expression at mRNA and peptide levels in human neuroblastoma cells.
Topics: Bucladesine; Carbachol; Humans; Neuroblastoma; Peptide Biosynthesis; Radioimmunoassay; RNA, Messenge | 1992 |
LAN-1: a human neuroblastoma cell line with M1 and M3 muscarinic receptor subtypes coupled to intracellular Ca2+ elevation and lacking Ca2+ channels activated by membrane depolarization.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Electrophysiology; Humans; Inositol | 1992 |
Inositol 1,4,5-trisphosphate receptor immunoreactivity in SH-SY5Y human neuroblastoma cells is reduced by chronic muscarinic receptor activation.
Topics: Antibodies, Monoclonal; Calcium Channels; Carbachol; Egtazic Acid; HEPES; Humans; Inositol 1,4,5-Tri | 1992 |
Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Carbachol; Carcinoma, Small Cell; Humans | 1992 |
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Analgesics; Brimonidine Tartrate; Buclade | 1992 |
Intracellular calcium release in N1E-115 neuroblastoma cells is mediated by the M1 muscarinic receptor subtype and is antagonized by McN-A-343.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Calcium; Calcium Chan | 1992 |
Elevation of cytosolic calcium by cholinoceptor agonists in SH-SY5Y human neuroblastoma cells: estimation of the contribution of voltage-dependent currents.
Topics: Calcium; Carbachol; Cell Membrane; Cytosol; Electric Conductivity; Electrophysiology; Ganglionic Sti | 1992 |
Carbachol stimulates binding of a photoreactive calmodulin derivative to calmodulin-binding proteins in intact SK-N-SH human neuroblastoma cells.
Topics: Affinity Labels; Calmodulin; Calmodulin-Binding Proteins; Carbachol; Cell Line; Cell Membrane; Cytos | 1992 |
Stimulus-induced accumulation of inositol tetrakis-, pentakis-, and hexakisphosphates in N1E-115 neuroblastoma cells.
Topics: Alprostadil; Animals; Carbachol; Inositol Phosphates; Mice; Neuroblastoma; Phytic Acid; Potassium; T | 1992 |
Essential fatty acid deficiency in cultured SK-N-SH human neuroblastoma cells.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Carbachol; Cell Membrane; Diglycerides; Fatty Acids, | 1992 |
Agonist-induced changes in [Ca2+]i in N1E-115 cells: differential effects of bradykinin and carbachol.
Topics: Bradykinin; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carbachol; Fura-2; Humans; | 1992 |
Study of the muscarinic receptor subtypes in N1E 115 mouse neuroblastoma cells.
Topics: Animals; Carbachol; Cyclic AMP; Cyclic GMP; Indicators and Reagents; Ligands; Mice; Neuroblastoma; P | 1991 |
Muscarinic receptor binding is inhibited by quinacrine.
Topics: Binding, Competitive; Calcium; Carbachol; Cyclic AMP; Muscarinic Antagonists; Neuroblastoma; Quinacr | 1991 |
Phosphoinositide turnover in human neuroblastoma cells (SK-N-BE).
Topics: Atropine; Carbachol; Cell Line; Humans; Inositol; Inositol Phosphates; Kinetics; Neuroblastoma; Phos | 1991 |
Differential coupling of muscarinic receptors to Ca2+ mobilization and cyclic AMP in SH-SY5Y and IMR 32 neuroblastoma cells.
Topics: Acetylcholine; Alprostadil; Atropine; Calcium; Carbachol; Cyclic AMP; Humans; Methacholine Chloride; | 1991 |
Chronic muscarinic stimulation of SH-SY5Y neuroblastoma cells suppresses inositol 1,4,5-trisphosphate action. Parallel inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ mobilization and inositol 1,4,5-trisphosphate binding.
Topics: Calcium; Calcium Channels; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Colforsi | 1991 |
Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C.
Topics: Adenylate Cyclase Toxin; Alprostadil; Calcium; Carbachol; Cholera Toxin; Cyclic AMP; Dose-Response R | 1991 |
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Topics: Adenylate Cyclase Toxin; Alprostadil; Animals; Carbachol; Cell Line; Cholera Toxin; Colforsin; Cycli | 1991 |
Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells.
Topics: Adenosine; Alprostadil; Atropine; Calmodulin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Drug Syne | 1991 |
D1 dopamine receptors of NS20Y neuroblastoma cells are functionally similar to rat striatal D1 receptors.
Topics: Benzazepines; Butaclamol; Carbachol; Cell Line; Colforsin; Corpus Striatum; Cyclic AMP; Dopamine; Do | 1991 |
The effect of calcium channel antagonists on the release of [3H]noradrenaline in the human neuroblastoma, SH-SY5Y.
Topics: Calcium Channel Blockers; Carbachol; Cations, Divalent; Cell Line; Humans; Nervous System Neoplasms; | 1991 |
Effects of insulin on glucose uptake in cultured cells from the central nervous system of rodent.
Topics: Animals; Calcium; Carbachol; Central Nervous System; Choline; Deoxyglucose; Glioma; Insulin; Kinetic | 1991 |
Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Buspirone; Carbachol; Hippocampus; Humans; Inositol Phosphat | 1991 |
Preferential coupling of cell surface muscarinic receptors to phosphoinositide hydrolysis in human neuroblastoma cells.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Chromatography, High Pressure Liquid; Humans; Hy | 1991 |
Potassium- and carbachol-evoked release of [3H]noradrenaline from human neuroblastoma cells, SH-SY5Y.
Topics: Calcimycin; Calcium Chloride; Carbachol; Egtazic Acid; Humans; Muscarine; Neuroblastoma; Norepinephr | 1991 |
Receptor-mediated generation of an EDRF-like intermediate in a neuronal cell line detected by spin trapping techniques.
Topics: Animals; Arginine; Benzenesulfonates; Carbachol; Electron Spin Resonance Spectroscopy; Enzyme Activa | 1990 |
EDRF release is a common pathway in the activation of guanylate cyclase by receptor agonists and calcium ionophores.
Topics: Arginine; Calcimycin; Calcium; Carbachol; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate | 1990 |
Accumulation and metabolism of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in muscarinic-receptor-stimulated SH-SY5Y neuroblastoma cells.
Topics: Animals; Carbachol; Cell Line; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics | 1991 |
Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover.
Topics: Alkaloids; Carbachol; Glycerophospholipids; Humans; Inositol Phosphates; Neuroblastoma; Phosphatidic | 1991 |
Potassium- and carbachol-evoked released of [3H]noradrenaline from human neuroblastoma cells, SH-SY5Y.
Topics: Calcimycin; Carbachol; Clone Cells; Drug Synergism; Humans; Neuroblastoma; Neurons; Norepinephrine; | 1990 |
Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation.
Topics: Adenylate Cyclase Toxin; Alprostadil; Animals; Carbachol; Cyclic AMP; Glioma; GTP-Binding Proteins; | 1990 |
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regu | 1990 |
Selective blockade of receptor-mediated cyclic GMP formation in N1E-115 neuroblastoma cells by an inhibitor of nitric oxide synthesis.
Topics: Animals; Arginine; Bradykinin; Carbachol; Cyclic GMP; Histamine; Mice; Neuroblastoma; Neurotensin; N | 1990 |
Polyphosphoinositides are the major source of inositol phosphates in carbamoylcholine-stimulated SK-N-SH neuroblastoma cells.
Topics: Calcium; Carbachol; Digitonin; Humans; Inositol Phosphates; Kinetics; Neuroblastoma; Phosphatidylino | 1990 |
Desensitization of muscarinic M1 receptors of murine neuroblastoma cells (clone N1E-115) without receptor down-regulation and protein kinase C activity.
Topics: Animals; Carbachol; Down-Regulation; Guanosine Monophosphate; Inositol Phosphates; Mice; N-Methylsco | 1990 |
Regulation by batrachotoxin, veratridine, and monensin of basal and carbachol-induced phosphoinositide hydrolysis in neurohybrid NCB-20 cells.
Topics: Batrachotoxins; Brain; Calcium; Carbachol; Chlorides; Hybrid Cells; Hydrolysis; Kinetics; Lithium; L | 1990 |
Different mechanisms of Ca2+ entry induced by depolarization and muscarinic receptor stimulation in SH-SY5Y human neuroblastoma cells.
Topics: Atropine; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Cell Membrane; Humans; Isradipine | 1990 |
Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Electric Stimulation; Guan | 1990 |
Coupling of muscarinic receptors to the mobilization of intracellular Ca2+ stores in permeabilized SH-SY5Y human neuroblastoma cells.
Topics: Calcium; Calcium Radioisotopes; Carbachol; Cell Line; Cell Membrane Permeability; Guanosine 5'-O-(3- | 1990 |
12-O-tetradecanoylphorbol 13-acetate and forskolin modify muscarinic receptor-linked Ca2+ mobilization in SH-SY5Y neuroblastoma cells through different mechanisms.
Topics: Benzofurans; Binding, Competitive; Biomechanical Phenomena; Calcium; Carbachol; Colforsin; Cytosol; | 1990 |
Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y.
Topics: Arecoline; Atropine; Benzofurans; Calcium; Carbachol; Cell Line; Fluorescent Dyes; Fura-2; Humans; I | 1990 |
Muscarinic receptor-mediated translocation of calmodulin in SK-N-SH human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Biological Transport; Calcium; Cal | 1990 |
Non-muscarinic effects of scopolamine on N1E-115 neuroblastoma cells.
Topics: Animals; Carbachol; Cell Line; Cell Membrane Permeability; Ion Channels; Membrane Potentials; Mice; | 1986 |
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase | 1986 |
Muscarinic receptors activate calcium channels and calcium dependent potassium channels in NlE-115 neuroblastoma cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Carbachol; Clone Cells; In Vitro Techniques; Ion Channel | 1987 |
The dynamics of cGMP metabolism in neuroblastoma N1E-115 cells determined by 18O labeling of guanine nucleotide alpha-phosphoryls.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1987 |
Alaproclate inhibits potassium currents and thereby enhances muscarinic stimulation in N1E-115 neuroblastoma cells.
Topics: Alanine; Antidepressive Agents; Calcium Radioisotopes; Carbachol; Cells, Cultured; Ion Channels; Mem | 1987 |
Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin.
Topics: Aminoquinolines; Arthropod Venoms; Atropine; Calcimycin; Calcium; Carbachol; Cytoplasm; Egtazic Acid | 1988 |
Chronic exposure to pertussis toxin alters muscarinic receptor-mediated regulation of cyclic AMP metabolism in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Atropine; Carbachol; Cyclic AMP; Glioma; Hybrid Cells; Neu | 1988 |
Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Carbachol; Cell Line; Colforsin; Cyclic AMP; H | 1988 |
Muscarinic receptor-stimulated phosphoinositide turnover in human SK-N-SH neuroblastoma cells: differential inhibition by agents that elevate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Bucladesine; Carbacho | 1989 |
Phosphoinositide hydrolysis in permeabilized SH-SY5Y human neuroblastoma cells is inhibited by mastoparan.
Topics: Bee Venoms; Calcium; Carbachol; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Gua | 1989 |
Differential sensitivity of phosphoinositide and cyclic GMP responses to short-term regulation by a muscarinic agonist in mouse neuroblastoma cells. Correlation with down-regulation of cell surface receptors.
Topics: Animals; Carbachol; Cyclic GMP; In Vitro Techniques; Inositol Phosphates; Mice; N-Methylscopolamine; | 1989 |
Mixed competitive and allosteric antagonism by gallamine of muscarinic receptor-mediated second messenger responses in N1E-115 neuroblastoma cells.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Carbachol; Cell Line; Cyclic AMP; Gallamine Tr | 1989 |
Cyclic nucleotide modulation of herpes simplex virus latency and reactivation.
Topics: Acyclovir; Animals; Carbachol; Cells, Cultured; Cholera Toxin; Neuroblastoma; Nucleotides, Cyclic; O | 1989 |
Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Benzyl Alcohol; Benzyl Alcohols; Cannabidiol; Cannab | 1989 |
The coupling of muscarinic receptors to hydrolysis of inositol lipids in human neuroblastoma SH-SY5Y cells.
Topics: Carbachol; Cyclic AMP; Humans; Inositol Phosphates; Neuroblastoma; Phospholipids; Receptors, Muscari | 1989 |
Muscarinic receptors coupled to phosphoinositide hydrolysis and elevated cytosolic calcium in a human neuroblastoma cell line SK-N-SH.
Topics: Benzofurans; Calcium; Carbachol; Cytosol; Fura-2; Humans; Hydrolysis; Inosine Triphosphate; Neurobla | 1989 |
Mechanism of agonist-induced down-regulation and subsequent recovery of muscarinic acetylcholine receptors in a clonal neuroblastoma x glioma hybrid cell line.
Topics: Animals; Bacitracin; Benzimidazoles; Carbachol; Cell Membrane; Colchicine; Endocytosis; Glioma; Hybr | 1989 |
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
Topics: Arecoline; Atropine; Carbachol; Cell Membrane; Humans; Neuroblastoma; Piperidines; Pirenzepine; Rece | 1989 |
Properties of neuronal type acetylcholine receptors in voltage clamped mouse neuroblastoma cells.
Topics: Acetylcholine; Animals; Carbachol; Membrane Potentials; Mice; Neuroblastoma; Nicotinic Antagonists; | 1989 |
Differential regulation by butyrate and dibutyryl cyclic AMP of delta-opioid, alpha 2-adrenergic, and muscarinic cholinergic receptors in NCB-20 cells.
Topics: Alprostadil; Animals; Binding, Competitive; Brain; Bucladesine; Butyrates; Butyric Acid; Carbachol; | 1988 |
Alteration in the regulation of neuronal muscarinic acetylcholine receptor number induced by chronic lithium in neuroblastoma cells.
Topics: Animals; Calcimycin; Carbachol; Cell Line; Cell Membrane; Chlorides; Kinetics; Lithium; Lithium Chlo | 1988 |
Modification of neuronal muscarinic receptor-mediated responses by islet-activating protein.
Topics: Adenosine Diphosphate Ribose; Animals; Carbachol; Cyclic AMP; GTP-Binding Proteins; Membrane Protein | 1988 |
Acute effects of ethanol and other short-chain alcohols on the guanylate cyclase system of murine neuroblastoma cells (clone N1E-115).
Topics: Alcohols; Animals; Arachidonic Acid; Arachidonic Acids; Carbachol; Cells, Cultured; Cyclic GMP; Dose | 1986 |
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cannabi | 1986 |
Depolarization of human neuroblastoma cells as a result of muscarinic receptor-induced rise in cytosolic Ca2+.
Topics: Calcium; Carbachol; Cytosol; Ethers; Humans; Ionomycin; Membrane Potentials; Neuroblastoma; Receptor | 1989 |
Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115). Mediation of separate responses by high affinity and low affinity agonist-receptor conformations.
Topics: Animals; Benzodiazepinones; Carbachol; Clone Cells; Cyclic AMP; Cyclic GMP; Kinetics; Mice; N-Methyl | 1985 |
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Topics: Adenylate Cyclase Toxin; Alprostadil; Animals; Bacterial Toxins; Carbachol; Cell Line; Cyclic AMP; C | 1985 |
Lithium ions inhibit function of low- but not high-affinity muscarinic receptors of murine neuroblastoma cells (clone N1E-115).
Topics: Alprostadil; Animals; Azides; Carbachol; Cells, Cultured; Cyclic GMP; Lithium; Mice; Neuroblastoma; | 1985 |
Carbachol-induced accumulation of inositol-1-phosphate in neurohybridoma NCB-20 cells: effects of lithium and phorbol esters.
Topics: Animals; Atropine; Benzodiazepinones; Brain; Carbachol; Cell Line; Chlorides; Cricetinae; Cricetulus | 1986 |
The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).
Topics: Animals; Carbachol; Cell Line; Cyclic GMP; Inositol Phosphates; Mice; Neuroblastoma; Phorbol Esters; | 1986 |
Short-term desensitization of muscarinic cholinergic receptors in mouse neuroblastoma cells: selective loss of agonist low-affinity and pirenzepine high-affinity binding sites.
Topics: Benzodiazepinones; Carbachol; Cells, Cultured; Cyclic GMP; N-Methylscopolamine; Neuroblastoma; Piren | 1986 |
Muscarinic responses and binding in a murine neuroblastoma clone (N1E-115): cyclic GMP formation is mediated by a low affinity agonist-receptor conformation and cyclic AMP reduction is mediated by a high affinity agonist-receptor conformation.
Topics: Animals; Benzodiazepinones; Carbachol; Cells, Cultured; Cyclic AMP; Cyclic GMP; N-Methylscopolamine; | 1986 |
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alprostadil; Atropine; Car | 1986 |
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP | 1987 |
Activation of dopamine receptors does not affect phosphoinositide turnover in NCB-20 cells.
Topics: Adenylate Cyclase Toxin; Animals; Brain; Carbachol; Cell Line; Colforsin; Cricetinae; Cricetulus; Cy | 1987 |
Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.
Topics: Animals; Calcimycin; Calcium; Carbachol; Cell Line; Diglycerides; Dose-Response Relationship, Drug; | 1986 |
Recognition of muscarinic cholinergic receptors in human SK-N-SH neuroblastoma cells by quaternary and tertiary ligands is dependent upon temperature, cell integrity, and the presence of agonists.
Topics: Atropine; Binding, Competitive; Carbachol; Humans; Kinetics; Ligands; N-Methylscopolamine; Neuroblas | 1988 |
Exposure to carbachol induces several changes in muscarinic cholinergic parameters in N1E-115 mouse neuroblastoma cells.
Topics: Animals; Binding Sites; Calcium; Carbachol; Cell Line; Cholinesterases; Cycloheximide; Mice; Neurobl | 1988 |
Muscarinic receptor-mediated hydrolysis of phosphatidylinositols in human neuroblastoma (SH-SY5Y) cells is sensitive to pertussis toxin.
Topics: Carbachol; Cell Line; Cholera Toxin; Humans; Hydrolysis; Neuroblastoma; Pertussis Toxin; Phosphatidy | 1988 |
Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function.
Topics: Animals; Binding Sites; Carbachol; Clone Cells; Enzyme Activation; Kinetics; Mice; Neuroblastoma; Ph | 1988 |
6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.
Topics: Acetylcholine; alpha-Amylases; Animals; Behavior, Animal; Carbachol; Cell Line; Chemical Phenomena; | 1987 |
Muscarinic activation of phosphatidylinositol breakdown in neuroblastoma cells.
Topics: Carbachol; Hydrolysis; Neuroblastoma; Phosphatidylinositols; Receptors, Muscarinic; Tumor Cells, Cul | 1987 |
Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas.
Topics: Animals; Brain; Carbachol; Cell Line; Cerebral Cortex; Corpus Striatum; Guinea Pigs; Hippocampus; Hu | 1987 |
Acetylcholine-activated currents in mouse neuroblastoma cells.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Line; Curare; Electrophysiology; Membrane Potentia | 1986 |
Regulation of neuronal muscarinic acetylcholine receptor number by protein glycosylation.
Topics: Animals; Carbachol; Carbohydrate Metabolism; Cell Line; Cell Membrane; Leucine; Mannose; Mice; Neuro | 1986 |
Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function.
Topics: Animals; Atropine; Carbachol; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Mic | 1985 |
Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells.
Topics: Carbachol; Cell Division; Cells, Cultured; Clone Cells; Culture Media; Cyclic AMP; Dopamine; Histami | 1971 |
Regulation of cyclic AMP metabolism in cultured cells of the nervous system.
Topics: Adenosine; Aminobutyrates; Animals; Brain; Carbachol; Catecholamines; Cell Division; Cells, Cultured | 1972 |
Regulation of acetylcholine receptors in relation to acetylcholinesterase in neuroblastoma cells.
Topics: Acetylcholinesterase; Animals; Atropine; Carbachol; Cell Differentiation; Cell Division; Clone Cells | 1973 |