carbachol has been researched along with Lesch-Nyhan Syndrome in 1 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In conclusion, HGprt deficiency in mice is associated with a decrease in colon contractility, not dependent upon reduction of acetylcholine release from the myenteric plexus or hyperactivity of inhibitory signalling." | 1.48 | Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease. ( Belluardo, N; Caciagli, F; Ciccarelli, R; Condorelli, DF; Di Iorio, P; Frinchi, M; Jinnah, HA; Mudò, G; Mulè, F; Nuzzo, D; Serio, R; Zizzo, MG, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zizzo, MG | 1 |
| Frinchi, M | 1 |
| Nuzzo, D | 1 |
| Jinnah, HA | 1 |
| Mudò, G | 1 |
| Condorelli, DF | 1 |
| Caciagli, F | 1 |
| Ciccarelli, R | 1 |
| Di Iorio, P | 1 |
| Mulè, F | 1 |
| Belluardo, N | 1 |
| Serio, R | 1 |
1 other study available for carbachol and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Altered gastrointestinal motility in an animal model of Lesch-Nyhan disease.
Topics: Animals; Atropine; Benzazepines; Brain; Carbachol; Cytokines; Disease Models, Animal; Dopamine; Enzy | 2018 |