carbachol has been researched along with Insulinoma in 26 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1 We have investigated the effects of loperamide on intracellular Ca(2+) stores and membrane K(+) channels in insulin-secreting hamster insulinoma (HIT-T15) cells." | 3.72 | Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells. ( Atwater, I; Cleemann, L; He, LP; Mears, D; Rojas, E, 2003) |
| "To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms." | 3.69 | Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis. ( Hertelendy, ZI; Knittel, JJ; Patel, DG, 1996) |
| " In this study, the effects of galanin and the galanin receptor antagonist, galantide, on the cytoplasmic free Ca2+ [Ca2+]i, were investigated in FURA 2-AM-loaded cells of the rat insulinoma cell line, RIN m5F, in cell suspensions in a cuvette." | 3.68 | Dual action of the neuropeptide galanin on the cytoplasmic free calcium concentration in RIN m5F cells. ( Ahrén, B; Fridolf, T, 1993) |
| "Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells." | 3.67 | Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells. ( Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T, 1987) |
| " On the other hand, beta II-PKC-like immunoreactivity was not detected in rat insulinoma cells, in which insulin secretion was induced in response to 12-O-tetradecanoylphorbol-13-acetate and carbachol but not in response to glucose." | 3.67 | Localization of beta II subspecies of protein kinase C in beta-cells. ( Chiba, T; Ito, A; Kikkawa, U; Saito, N; Saitoh, Y; Tanaka, C; Taniguchi, H, 1989) |
| "Carbachol was used as a control test agent for the parameters involving the inositol phosphate/Ca2+ cascade." | 1.28 | Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells. ( Bataille, D; Estival, A; Jarrousse, C; Le Quellec, A; Martinez, J; Pradayrol, L; Sladeczek, F; Tani, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (26.92) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, LP | 1 |
| Mears, D | 2 |
| Atwater, I | 1 |
| Rojas, E | 1 |
| Cleemann, L | 1 |
| Zimliki, CL | 1 |
| Bach, AG | 1 |
| Wolgast, S | 1 |
| Mühlbauer, E | 1 |
| Peschke, E | 1 |
| Fridolf, T | 1 |
| Ahrén, B | 2 |
| Mayer, P | 1 |
| Jochum, C | 1 |
| Schatz, H | 1 |
| Pfeiffer, A | 1 |
| Sjöholm, A | 2 |
| Arkhammar, P | 1 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 2 |
| Waheed, A | 1 |
| Koopmann, I | 1 |
| Ammon, HP | 1 |
| Hertelendy, ZI | 1 |
| Patel, DG | 1 |
| Knittel, JJ | 1 |
| Xu, G | 1 |
| Howland, J | 1 |
| Rothenberg, PL | 1 |
| Konard, RJ | 1 |
| Stoller, JZ | 1 |
| Gao, ZY | 1 |
| Wolf, BA | 1 |
| Deeg, MA | 1 |
| Verchere, CB | 1 |
| Xu, S | 1 |
| Khoo, S | 1 |
| Dang, A | 1 |
| Witt, S | 1 |
| Do, V | 1 |
| Zhen, E | 1 |
| Schaefer, EM | 1 |
| Cobb, MH | 1 |
| Tang, SH | 1 |
| Sharp, GW | 3 |
| Karlsson, S | 1 |
| Sundler, F | 1 |
| Cooney, RV | 1 |
| Lee, B | 1 |
| Laychock, SG | 1 |
| Varadi, A | 1 |
| Rutter, GA | 1 |
| Tani, T | 1 |
| Le Quellec, A | 1 |
| Jarrousse, C | 1 |
| Sladeczek, F | 1 |
| Martinez, J | 1 |
| Estival, A | 1 |
| Pradayrol, L | 1 |
| Bataille, D | 1 |
| D'Ambra, R | 1 |
| Surana, M | 1 |
| Efrat, S | 1 |
| Starr, RG | 1 |
| Fleischer, N | 1 |
| Chiba, T | 3 |
| Yamatani, T | 2 |
| Kadowaki, S | 2 |
| Yamaguchi, A | 2 |
| Inui, T | 2 |
| Saito, Y | 1 |
| Fujita, T | 2 |
| Yada, T | 1 |
| Russo, LL | 1 |
| Ito, A | 1 |
| Saito, N | 1 |
| Taniguchi, H | 1 |
| Kikkawa, U | 1 |
| Saitoh, Y | 1 |
| Tanaka, C | 1 |
| Hishikawa, R | 1 |
| Kawazu, S | 1 |
| Prentki, M | 1 |
| Glennon, MC | 1 |
| Thomas, AP | 1 |
| Morris, RL | 1 |
| Matschinsky, FM | 1 |
| Corkey, BE | 1 |
| Gylfe, E | 1 |
| Hellman, B | 1 |
| Hoenig, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 other studies available for carbachol and Insulinoma
| Article | Year |
|---|---|
Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells.
Topics: Animals; Calcium; Calcium Channels; Carbachol; Cell Line, Tumor; Charybdotoxin; Cricetinae; Inositol | 2003 |
Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells.
Topics: Acetylcholine; Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Carbachol; Cell Lin | 2004 |
Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells.
Topics: Animals; Calcium; Carbachol; Cell Line, Tumor; Electrophoresis, Agar Gel; Inositol 1,4,5-Trisphospha | 2005 |
Dual action of the neuropeptide galanin on the cytoplasmic free calcium concentration in RIN m5F cells.
Topics: Animals; Calcium; Carbachol; Cytoplasm; Galanin; Glyceraldehyde; In Vitro Techniques; Insulin; Insul | 1993 |
Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells.
Topics: Animals; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Ethers, Cyclic; Insulin; Insulinoma; Marine | 1994 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Calmodulin antagonist W7 increases inositol phosphates in insulin secreting RINm5F cells.
Topics: Animals; Calmodulin; Carbachol; Chromatography, High Pressure Liquid; Inositol Phosphates; Insulin; | 1995 |
Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis.
Topics: Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Carbachol; Chromogranin A; Exocytosis; Glyceral | 1996 |
Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting beta-cells.
Topics: Androstadienes; Animals; Carbachol; CHO Cells; Clone Cells; Cricetinae; Glucose; Humans; Insulin; In | 1996 |
Eicosapentaenoic acid (C20:5) augments glucose-induced insulin secretion from beta-TC3 insulinoma cells.
Topics: Calcium; Carbachol; Drug Synergism; Eicosapentaenoic Acid; Exocytosis; Glucose; Insulin; Insulin Sec | 1996 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; G | 1997 |
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Topics: 3T3 Cells; Aluminum Compounds; Animals; Antibodies, Monoclonal; Astrocytes; Carbachol; Cell Line; CH | 1997 |
Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.
Topics: Animals; Carbachol; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin S | 1998 |
CCK receptor subtype in insulin-producing cells: a combined functional and in situ hybridization study in rat islets and a rat insulinoma cell line.
Topics: Animals; Calcium; Carbachol; Fura-2; Gastric Mucosa; Immunohistochemistry; In Situ Hybridization; In | 1998 |
gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Carbachol; Cell Division; Cell Line; Cell Sur | 2000 |
Inositol 1,4,5-trisphosphate receptor isoform expression in mouse pancreatic islets: effects of carbachol.
Topics: Analysis of Variance; Animals; Calcium Channels; Carbachol; Cholinergic Agonists; Gene Expression Re | 2001 |
Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 Cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors.
Topics: Boron Compounds; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Carbachol; Chlor | 2002 |
Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells.
Topics: Animals; Calcium; Carbachol; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like P | 1991 |
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Sy | 1990 |
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans; | 1987 |
Phorbol ester-stimulated insulin secretion by RINm5F insulinoma cells is linked with membrane depolarization and an increase in cytosolic free Ca2+ concentration.
Topics: Adenoma, Islet Cell; Animals; Benzofurans; Calcium; Carbachol; Cell Line; Cell Membrane; Cytosol; Et | 1989 |
Localization of beta II subspecies of protein kinase C in beta-cells.
Topics: Animals; Antibodies, Monoclonal; Carbachol; Female; Glucose; Immunohistochemistry; Insulin; Insulin | 1989 |
Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr).
Topics: Adenoma, Islet Cell; Animals; Carbachol; Cell Membrane; Enzyme Activation; Inositol Phosphates; Insu | 1988 |
Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Calcium; Carbachol; Cell Line; Cytosol; Fluorometry; Homeostasis; Insu | 1988 |
Glucose-stimulated sequestration of Ca2+ in clonal insulin-releasing cells. Evidence for an opposing effect of muscarinic-receptor activation.
Topics: Adenoma, Islet Cell; Animals; Atropine; Calcium; Carbachol; Cell Line; Clone Cells; Glucose; Insulin | 1986 |
Glucose induces insulin release and a rise in cytosolic calcium concentration in a transplantable rat insulinoma.
Topics: Adenoma, Islet Cell; Aminoquinolines; Animals; Calcium; Carbachol; Cytosol; Dose-Response Relationsh | 1986 |