Page last updated: 2024-11-07

carbachol and Insulinoma

carbachol has been researched along with Insulinoma in 26 studies

Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Research Excerpts

ExcerptRelevanceReference
"1 We have investigated the effects of loperamide on intracellular Ca(2+) stores and membrane K(+) channels in insulin-secreting hamster insulinoma (HIT-T15) cells."3.72Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells. ( Atwater, I; Cleemann, L; He, LP; Mears, D; Rojas, E, 2003)
"To elucidate the regulatory pathway through which pancreastatin inhibits insulin secretion, RINm5F insulinoma cells were challenged with physiological and pharmacological probes known to stimulate insulin release through different mechanisms."3.69Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis. ( Hertelendy, ZI; Knittel, JJ; Patel, DG, 1996)
" In this study, the effects of galanin and the galanin receptor antagonist, galantide, on the cytoplasmic free Ca2+ [Ca2+]i, were investigated in FURA 2-AM-loaded cells of the rat insulinoma cell line, RIN m5F, in cell suspensions in a cuvette."3.68Dual action of the neuropeptide galanin on the cytoplasmic free calcium concentration in RIN m5F cells. ( Ahrén, B; Fridolf, T, 1993)
"Glucose, forskolin, IBMX and carbachol all stimulated insulin release from freshly obtained human insulinoma cells."3.67Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells. ( Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T, 1987)
" On the other hand, beta II-PKC-like immunoreactivity was not detected in rat insulinoma cells, in which insulin secretion was induced in response to 12-O-tetradecanoylphorbol-13-acetate and carbachol but not in response to glucose."3.67Localization of beta II subspecies of protein kinase C in beta-cells. ( Chiba, T; Ito, A; Kikkawa, U; Saito, N; Saitoh, Y; Tanaka, C; Taniguchi, H, 1989)
"Carbachol was used as a control test agent for the parameters involving the inositol phosphate/Ca2+ cascade."1.28Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells. ( Bataille, D; Estival, A; Jarrousse, C; Le Quellec, A; Martinez, J; Pradayrol, L; Sladeczek, F; Tani, T, 1991)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19907 (26.92)18.7374
1990's13 (50.00)18.2507
2000's6 (23.08)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
He, LP1
Mears, D2
Atwater, I1
Rojas, E1
Cleemann, L1
Zimliki, CL1
Bach, AG1
Wolgast, S1
Mühlbauer, E1
Peschke, E1
Fridolf, T1
Ahrén, B2
Mayer, P1
Jochum, C1
Schatz, H1
Pfeiffer, A1
Sjöholm, A2
Arkhammar, P1
Welsh, N1
Bokvist, K1
Rorsman, P1
Hallberg, A1
Nilsson, T1
Welsh, M1
Berggren, PO2
Waheed, A1
Koopmann, I1
Ammon, HP1
Hertelendy, ZI1
Patel, DG1
Knittel, JJ1
Xu, G1
Howland, J1
Rothenberg, PL1
Konard, RJ1
Stoller, JZ1
Gao, ZY1
Wolf, BA1
Deeg, MA1
Verchere, CB1
Xu, S1
Khoo, S1
Dang, A1
Witt, S1
Do, V1
Zhen, E1
Schaefer, EM1
Cobb, MH1
Tang, SH1
Sharp, GW3
Karlsson, S1
Sundler, F1
Cooney, RV1
Lee, B1
Laychock, SG1
Varadi, A1
Rutter, GA1
Tani, T1
Le Quellec, A1
Jarrousse, C1
Sladeczek, F1
Martinez, J1
Estival, A1
Pradayrol, L1
Bataille, D1
D'Ambra, R1
Surana, M1
Efrat, S1
Starr, RG1
Fleischer, N1
Chiba, T3
Yamatani, T2
Kadowaki, S2
Yamaguchi, A2
Inui, T2
Saito, Y1
Fujita, T2
Yada, T1
Russo, LL1
Ito, A1
Saito, N1
Taniguchi, H1
Kikkawa, U1
Saitoh, Y1
Tanaka, C1
Hishikawa, R1
Kawazu, S1
Prentki, M1
Glennon, MC1
Thomas, AP1
Morris, RL1
Matschinsky, FM1
Corkey, BE1
Gylfe, E1
Hellman, B1
Hoenig, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

26 other studies available for carbachol and Insulinoma

ArticleYear
Loperamide mobilizes intracellular Ca2+ stores in insulin-secreting HIT-T15 cells.
    British journal of pharmacology, 2003, Volume: 139, Issue:2

    Topics: Animals; Calcium; Calcium Channels; Carbachol; Cell Line, Tumor; Charybdotoxin; Cricetinae; Inositol

2003
Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells.
    The Journal of membrane biology, 2004, Jan-01, Volume: 197, Issue:1

    Topics: Acetylcholine; Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Carbachol; Cell Lin

2004
Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells.
    Journal of pineal research, 2005, Volume: 39, Issue:3

    Topics: Animals; Calcium; Carbachol; Cell Line, Tumor; Electrophoresis, Agar Gel; Inositol 1,4,5-Trisphospha

2005
Dual action of the neuropeptide galanin on the cytoplasmic free calcium concentration in RIN m5F cells.
    Biochemical and biophysical research communications, 1993, Mar-31, Volume: 191, Issue:3

    Topics: Animals; Calcium; Carbachol; Cytoplasm; Galanin; Glyceraldehyde; In Vitro Techniques; Insulin; Insul

1993
Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells.
    Experimental and clinical endocrinology, 1994, Volume: 102, Issue:4

    Topics: Animals; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Ethers, Cyclic; Insulin; Insulinoma; Marine

1994
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne

1993
Calmodulin antagonist W7 increases inositol phosphates in insulin secreting RINm5F cells.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1995, Volume: 103, Issue:5

    Topics: Animals; Calmodulin; Carbachol; Chromatography, High Pressure Liquid; Inositol Phosphates; Insulin;

1995
Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated, calcium-directed exocytosis.
    Cell calcium, 1996, Volume: 19, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Carbachol; Chromogranin A; Exocytosis; Glyceral

1996
Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting beta-cells.
    The Biochemical journal, 1996, Sep-01, Volume: 318 ( Pt 2)

    Topics: Androstadienes; Animals; Carbachol; CHO Cells; Clone Cells; Cricetinae; Glucose; Humans; Insulin; In

1996
Eicosapentaenoic acid (C20:5) augments glucose-induced insulin secretion from beta-TC3 insulinoma cells.
    Pancreas, 1996, Volume: 13, Issue:3

    Topics: Calcium; Carbachol; Drug Synergism; Eicosapentaenoic Acid; Exocytosis; Glucose; Insulin; Insulin Sec

1996
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
    Endocrinology, 1997, Volume: 138, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; G

1997
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
    Molecular endocrinology (Baltimore, Md.), 1997, Volume: 11, Issue:11

    Topics: 3T3 Cells; Aluminum Compounds; Animals; Antibodies, Monoclonal; Astrocytes; Carbachol; Cell Line; CH

1997
Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.
    Diabetes, 1998, Volume: 47, Issue:6

    Topics: Animals; Carbachol; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Insulin; Insulin S

1998
CCK receptor subtype in insulin-producing cells: a combined functional and in situ hybridization study in rat islets and a rat insulinoma cell line.
    Regulatory peptides, 1998, Nov-30, Volume: 78, Issue:1-3

    Topics: Animals; Calcium; Carbachol; Fura-2; Gastric Mucosa; Immunohistochemistry; In Situ Hybridization; In

1998
gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
    Biochemical and biophysical research communications, 2000, Oct-22, Volume: 277, Issue:2

    Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Carbachol; Cell Division; Cell Line; Cell Sur

2000
Inositol 1,4,5-trisphosphate receptor isoform expression in mouse pancreatic islets: effects of carbachol.
    Biochemical pharmacology, 2001, Feb-01, Volume: 61, Issue:3

    Topics: Analysis of Variance; Animals; Calcium Channels; Carbachol; Cholinergic Agonists; Gene Expression Re

2001
Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 Cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors.
    Diabetes, 2002, Volume: 51 Suppl 1

    Topics: Boron Compounds; Caffeine; Calcium; Calcium Channels; Calcium-Transporting ATPases; Carbachol; Chlor

2002
Oxyntomodulin and related peptides control somatostatin secretion in RIN T3 cells.
    Biochimica et biophysica acta, 1991, Nov-12, Volume: 1095, Issue:3

    Topics: Animals; Calcium; Carbachol; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like P

1991
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
    Endocrinology, 1990, Volume: 126, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Sy

1990
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
    Biochemical and biophysical research communications, 1987, May-29, Volume: 145, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans;

1987
Phorbol ester-stimulated insulin secretion by RINm5F insulinoma cells is linked with membrane depolarization and an increase in cytosolic free Ca2+ concentration.
    The Journal of biological chemistry, 1989, Feb-15, Volume: 264, Issue:5

    Topics: Adenoma, Islet Cell; Animals; Benzofurans; Calcium; Carbachol; Cell Line; Cell Membrane; Cytosol; Et

1989
Localization of beta II subspecies of protein kinase C in beta-cells.
    Diabetes, 1989, Volume: 38, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Carbachol; Female; Glucose; Immunohistochemistry; Insulin; Insulin

1989
Dual action of protein kinase C activation in the regulation of insulin release by muscarinic agonist from rat insulinoma cell line (RINr).
    Endocrinology, 1988, Volume: 122, Issue:6

    Topics: Adenoma, Islet Cell; Animals; Carbachol; Cell Membrane; Enzyme Activation; Inositol Phosphates; Insu

1988
Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells.
    The Journal of biological chemistry, 1988, Aug-15, Volume: 263, Issue:23

    Topics: Adenoma, Islet Cell; Animals; Calcium; Carbachol; Cell Line; Cytosol; Fluorometry; Homeostasis; Insu

1988
Glucose-stimulated sequestration of Ca2+ in clonal insulin-releasing cells. Evidence for an opposing effect of muscarinic-receptor activation.
    The Biochemical journal, 1986, Feb-01, Volume: 233, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Atropine; Calcium; Carbachol; Cell Line; Clone Cells; Glucose; Insulin

1986
Glucose induces insulin release and a rise in cytosolic calcium concentration in a transplantable rat insulinoma.
    Endocrinology, 1986, Volume: 119, Issue:6

    Topics: Adenoma, Islet Cell; Aminoquinolines; Animals; Calcium; Carbachol; Cytosol; Dose-Response Relationsh

1986