carbachol has been researched along with Hirschsprung Disease in 6 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Hirschsprung Disease: Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The changes in the contractile activity of the smooth-muscle strips after carbachol applied cumulatively were examined and dose-response curves were plotted." | 1.28 | Changes in the responsiveness of the colonic smooth muscle to carbachol in Hirschsprung's disease. ( Apostolov, A; Atanassova, E; Boyanov, A; Christov, C; Ivanchev, I; Noeva, A; Todorov, S; Zlatarski, G, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GREENBLATT, J | 1 |
| Bekkali, N | 1 |
| de Jonge, HR | 1 |
| van den Wijngaard, RM | 1 |
| van der Steeg, AF | 1 |
| Bijlsma, PB | 1 |
| Taminiau, JA | 1 |
| Desjeux, JF | 1 |
| Benninga, MA | 1 |
| Nakatsuji, T | 1 |
| Ieiri, S | 1 |
| Masumoto, K | 1 |
| Akiyoshi, J | 1 |
| Taguchi, T | 1 |
| Suita, S | 1 |
| Won, KJ | 1 |
| Torihashi, S | 1 |
| Mitsui-Saito, M | 1 |
| Hori, M | 1 |
| Sato, K | 1 |
| Suzuki, T | 1 |
| Ozaki, H | 1 |
| Karaki, H | 1 |
| Atanassova, E | 1 |
| Todorov, S | 1 |
| Noeva, A | 1 |
| Ivanchev, I | 1 |
| Boyanov, A | 1 |
| Christov, C | 1 |
| Zlatarski, G | 1 |
| Apostolov, A | 1 |
| Carey, HV | 1 |
| Cooke, HJ | 1 |
| Gerthoffer, WT | 1 |
| Welling, LW | 1 |
6 other studies available for carbachol and Hirschsprung Disease
| Article | Year |
|---|---|
Carbaminoylcholine (doryl) in the treatment of congenital megacolon.
Topics: Carbachol; Colon; Dilatation; Hirschsprung Disease; Humans | 1947 |
The role of rectal chloride secretion in childhood constipation.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biopsy; Carbachol; Child; Chlorides; Cholinergic Agonists; C | 2011 |
Intracellular calcium mobilization of the aganglionic intestine in the endothelin B receptor gene-deficient rat.
Topics: Animals; Calcium Channels, L-Type; Calcium Signaling; Carbachol; Cholinergic Agonists; Colon; Diseas | 2007 |
Increased smooth muscle contractility of intestine in the genetic null of the endothelin ETB receptor: a rat model for long segment Hirschsprung's disease.
Topics: Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; | 2002 |
Changes in the responsiveness of the colonic smooth muscle to carbachol in Hirschsprung's disease.
Topics: Atropine; Carbachol; Colon; Electric Stimulation; Hirschsprung Disease; Humans; In Vitro Techniques; | 1991 |
Intestinal transport in megacolonic mice. Alterations in sugar absorption.
Topics: 3-O-Methylglucose; Alanine; Animals; Carbachol; DNA; Electrophysiology; Female; Hirschsprung Disease | 1989 |