carbachol has been researched along with Colonic Neoplasms in 49 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study used an in vitro model of colonic secretion, monolayers of T84 colonic adenocarcinoma cells mounted in Ussing chambers, to demonstrate that 100 mumol/L of either tangeritin or nobiletin, polymethoxylated flavonoids contained in citrus fruits, stimulated sustained electrogenic chloride secretion with a maximal short-circuit current of 3." | 3.68 | Citrus flavonoids stimulate secretion by human colonic T84 cells. ( Canada, AT; Nguyen, TD, 1993) |
| "This carbachol effect was almost completely blocked by the PI3K inhibitor LY294002, implying that PI3K is responsible for the Akt activation." | 1.43 | The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells. ( Cho, NJ; Liu, Z; Park, YS; Vasamsetti, BM, 2016) |
| "It has been reported that colon cancer cells express muscarinic acetylcholine receptor (mAChR) although their functional role is largely unknown." | 1.32 | Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. ( Kusayanagi, S; Mitamura, K; Takeuchi, Y; Ukegawa, JI, 2003) |
| "It is frequently expressed on human colon cancer cells and is biologically active." | 1.31 | Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. ( Frucht, H; Yang, WL, 2000) |
| "Treatment with carbachol, calcium ionophores or phorbol ester did not acutely affect chloride efflux." | 1.29 | Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells. ( Bear, CE; Krolczyk, AJ; Lai, PF; Schimmer, BP, 1995) |
| " Significant dose-response curves were obtained for both carbamylcholine and atropine." | 1.29 | [Isolated smooth muscle cells of the human colon. Cytophysiological study]. ( Balas, D; Giannarelli, S; Rampal, P, 1993) |
| "Studies demonstrate that some colon cancers possess receptors for various gastrointestinal hormones or neurotransmitters, the occupation of which can affect growth." | 1.28 | Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. ( Frucht, H; Gazdar, AF; Jensen, RT; Oie, H; Park, JA, 1992) |
| "The carbachol-stimulated increase in gK appeared to be the direct result of the increase in steady-state [Ca]'i." | 1.28 | Carbachol increases basolateral K+ conductance in T84 cells. Simultaneous measurements of cell [Ca] and gK explore calcium's role. ( Chase, HS; DeBell, MC; Tesfaye, A; Wong, SM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.29) | 18.7374 |
| 1990's | 34 (69.39) | 18.2507 |
| 2000's | 5 (10.20) | 29.6817 |
| 2010's | 3 (6.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, YS | 3 |
| Liu, Z | 1 |
| Vasamsetti, BM | 1 |
| Cho, NJ | 3 |
| Toumi, F | 1 |
| Frankson, M | 1 |
| Ward, JB | 1 |
| Kelly, OB | 1 |
| Mroz, MS | 1 |
| Bertelsen, LS | 1 |
| Keely, SJ | 1 |
| Cheng, K | 1 |
| Chen, Y | 1 |
| Zimniak, P | 1 |
| Raufman, JP | 1 |
| Xiao, Y | 1 |
| Frucht, H | 3 |
| Ukegawa, JI | 1 |
| Takeuchi, Y | 1 |
| Kusayanagi, S | 1 |
| Mitamura, K | 1 |
| ARDEMAN, S | 1 |
| CHANARIN, I | 1 |
| DOYLE, JC | 1 |
| Maselli, MA | 1 |
| Piepoli, AL | 1 |
| Guerra, V | 1 |
| Caruso, ML | 1 |
| Pezzolla, F | 1 |
| Lorusso, D | 1 |
| Demma, I | 1 |
| De Ponti, F | 1 |
| McCool, DJ | 2 |
| Forstner, JF | 2 |
| Forstner, GG | 2 |
| Krolczyk, AJ | 1 |
| Bear, CE | 1 |
| Lai, PF | 1 |
| Schimmer, BP | 1 |
| Tabcharani, JA | 1 |
| Harris, RA | 1 |
| Boucher, A | 1 |
| Eng, JW | 1 |
| Hanrahan, JW | 1 |
| Bischof, G | 1 |
| Brenman, J | 1 |
| Bredt, DS | 1 |
| Machen, TE | 2 |
| Warhurst, G | 1 |
| Fogg, KE | 1 |
| Higgs, NB | 1 |
| Tonge, A | 1 |
| Grundy, J | 1 |
| Bou-Hanna, C | 1 |
| Berthon, B | 2 |
| Combettes, L | 1 |
| Claret, M | 1 |
| Laboisse, CL | 2 |
| Valverde, MA | 1 |
| Mintenig, GM | 1 |
| Sepúlveda, FV | 1 |
| Dagher, PC | 1 |
| Morton, TZ | 1 |
| Joo, CS | 1 |
| Taglietta-Kohlbrecher, A | 1 |
| Egnor, RW | 1 |
| Charney, AN | 1 |
| Stenson, WF | 1 |
| Easom, RA | 1 |
| Riehl, TE | 1 |
| Turk, J | 1 |
| Giannarelli, S | 1 |
| Balas, D | 1 |
| Rampal, P | 1 |
| Bajnath, RB | 2 |
| van den Berghe, N | 1 |
| De Jonge, HR | 3 |
| Groot, JA | 3 |
| Nguyen, TD | 2 |
| Canada, AT | 2 |
| Vajanaphanich, M | 1 |
| Kachintorn, U | 1 |
| Barrett, KE | 1 |
| Cohn, JA | 1 |
| Dharmsathaphorn, K | 3 |
| Traynor-Kaplan, A | 1 |
| Kerr, PM | 1 |
| Hillier, K | 1 |
| Wallis, RM | 1 |
| Garland, CJ | 1 |
| Awad, AB | 1 |
| Ntanios, FY | 1 |
| Fink, CS | 1 |
| Horvath, PJ | 1 |
| Sand, P | 1 |
| Svenberg, T | 1 |
| Rydqvist, B | 1 |
| Poronnik, P | 1 |
| O'Mullane, LM | 1 |
| Harding, EA | 1 |
| Greger, R | 4 |
| Cook, DI | 1 |
| Yang, WL | 1 |
| Gazdar, AF | 1 |
| Park, JA | 1 |
| Oie, H | 1 |
| Jensen, RT | 1 |
| Augeron, C | 1 |
| Voisin, T | 1 |
| Maoret, JJ | 1 |
| Laburthe, M | 1 |
| Dekker, K | 1 |
| Vaandrager, AB | 2 |
| Dickinson, KE | 1 |
| Frizzell, RA | 2 |
| Sekar, MC | 1 |
| Lohrmann, E | 1 |
| Cabantchik, ZI | 1 |
| Kunzelmann, K | 2 |
| Kubitz, R | 1 |
| Grolik, M | 1 |
| Warth, R | 1 |
| Illek, B | 1 |
| Fischer, H | 1 |
| Levine, SA | 1 |
| Donowitz, M | 2 |
| Watson, AJ | 1 |
| Sharp, GW | 1 |
| Crane, JK | 1 |
| Weikel, CS | 1 |
| Bajnath, R | 1 |
| Bot, AG | 1 |
| Venglarik, CJ | 1 |
| Bridges, RJ | 1 |
| Wu, H | 1 |
| Franklin, CC | 1 |
| Kim, HD | 1 |
| Turner, JT | 1 |
| Devor, DC | 1 |
| Simasko, SM | 1 |
| Duffey, ME | 1 |
| Marcon, MA | 1 |
| Wong, SM | 2 |
| Tesfaye, A | 1 |
| DeBell, MC | 1 |
| Chase, HS | 2 |
| Kopp, R | 2 |
| Mayer, P | 1 |
| Pfeiffer, A | 2 |
| Cohn, J | 1 |
| Beuerlein, G | 1 |
| Reinlib, L | 1 |
| Mikkelsen, R | 1 |
| Zahniser, D | 1 |
| Lambrecht, G | 1 |
| Mutschler, E | 1 |
| Moser, U | 1 |
| Tacke, R | 1 |
| Lindeman, RP | 1 |
| Parangi, S | 1 |
| Phillips, TE | 1 |
| Huet, C | 2 |
| Bilbo, PR | 1 |
| Podolsky, DK | 1 |
| Louvard, D | 2 |
| Neutra, MR | 1 |
| Sahuquillo-Merino, C | 1 |
| Coudrier, E | 1 |
49 other studies available for carbachol and Colonic Neoplasms
| Article | Year |
|---|---|
The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells.
Topics: Apoptosis; Blotting, Western; Carbachol; Cell Proliferation; Cholinergic Agonists; Colonic Neoplasms | 2016 |
Enhanced proliferation of SNU-407 human colon cancer cells by muscarinic acetylcholine receptors.
Topics: Atropine; Carbachol; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Flavonoids; | 2008 |
Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors.
Topics: Adenocarcinoma; Calcium; Carbachol; Cell Line, Tumor; Chlorides; Colforsin; Colonic Neoplasms; Epith | 2011 |
EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.
Topics: Calcium; Carbachol; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Enzyme Activation; ErbB | 2012 |
Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line.
Topics: Acetylcholine; Apoptosis; Carbachol; Cell Division; Colonic Neoplasms; Dose-Response Relationship, D | 2002 |
Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells.
Topics: Carbachol; Cell Division; Cholinergic Agonists; Colonic Neoplasms; Enzyme Activation; ErbB Receptors | 2003 |
STUDIES ON SECRETION OF GASTRIC INTRINSIC FACTOR IN MAN.
Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Carbachol; Celiac Disease; Cobalt Isotopes; Colonic | 1964 |
Colonic smooth muscle responses in patients with diverticular disease of the colon: effect of the NK2 receptor antagonist SR48968.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Atropine; Benzamides; Carbachol; Case-Control Studies; | 2004 |
Regulated and unregulated pathways for MUC2 mucin secretion in human colonic LS180 adenocarcinoma cells are distinct.
Topics: Adenocarcinoma; Biomarkers, Tumor; Calcimycin; Carbachol; Cell Size; Colchicine; Colonic Neoplasms; | 1995 |
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Topics: Carbachol; Chloride Channels; Colforsin; Colonic Neoplasms; Cyclic AMP; Cyclic AMP-Dependent Protein | 1995 |
Basolateral K channel activated by carbachol in the epithelial cell line T84.
Topics: 4-Aminopyridine; Calcimycin; Carbachol; Cell Membrane; Charybdotoxin; Colonic Neoplasms; Cyclic AMP; | 1994 |
Possible regulation of capacitative Ca2+ entry into colonic epithelial cells by NO and cGMP.
Topics: Amino Acid Oxidoreductases; Aminoquinolines; Arginine; Barium; Biological Transport; Calcium; Carbac | 1995 |
Ca(2+)-mobilising agonists potentiate forskolin- and VIP-stimulated cAMP production in human colonic cell line, HT29-cl.19A: role of [Ca2+]i and protein kinase C.
Topics: Adenocarcinoma; Calcium; Calmodulin; Carbachol; Colforsin; Colonic Neoplasms; Cyclic AMP; Drug Syner | 1994 |
Role of calcium in carbachol- and neurotensin-induced mucin exocytosis in a human colonic goblet cell line and cross-talk with the cyclic AMP pathway.
Topics: Atropine; Calcium; Carbachol; Clone Cells; Colon; Colonic Neoplasms; Epithelial Cells; Epithelium; E | 1994 |
Cl- currents of unstimulated T84 intestinal epithelial cells studied by intracellular recording.
Topics: Carbachol; Chlorides; Colonic Neoplasms; Electric Conductivity; Epithelium; Humans; Intestinal Mucos | 1994 |
Modulation of secretagogue-induced chloride secretion by intracellular bicarbonate.
Topics: Analysis of Variance; Animals; Bicarbonates; Bucladesine; Carbachol; Cell Line; Chlorides; Colon; Co | 1994 |
Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C.
Topics: Adenocarcinoma; Alkaloids; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Colonic | 1993 |
[Isolated smooth muscle cells of the human colon. Cytophysiological study].
Topics: Atropine; Carbachol; Colon; Colonic Neoplasms; Humans; Muscle Contraction; Muscle Relaxation; Muscle | 1993 |
Activation of ion transport by combined effects of ionomycin, forskolin and phorbol ester on cultured HT-29cl.19A human colonocytes.
Topics: Biological Transport; Calcium; Carbachol; Chloride Channels; Colforsin; Colonic Neoplasms; Cyclic AM | 1993 |
Modulation of human colonic T84 cell secretion by hydrogen peroxide.
Topics: Adenocarcinoma; Carbachol; Catalase; Chlorides; Colonic Neoplasms; Deferoxamine; Dithiothreitol; Ele | 1994 |
Citrus flavonoids stimulate secretion by human colonic T84 cells.
Topics: Adenocarcinoma; Carbachol; Chlorides; Citrus; Colon; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Drug | 1993 |
Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
Topics: Calcium; Carbachol; Chlorides; Chromatography, Thin Layer; Colonic Neoplasms; Cyclic AMP; Cytosol; E | 1993 |
Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon.
Topics: Alkaloids; Atropine; Carbachol; Carcinoma; Colon; Colonic Neoplasms; Dose-Response Relationship, Dru | 1995 |
Effect of membrane lipid alteration on the growth, phospholipase C activity and G protein of HT-29 tumor cells.
Topics: Alamethicin; Calcium; Carbachol; Cell Division; Colonic Neoplasms; Deoxycholic Acid; Enzyme Activati | 1996 |
Carbachol induces oscillations in membrane potential and intracellular calcium in a colonic tumor cell line, HT-29.
Topics: Calcium; Carbachol; Cell Membrane; Chlorides; Colonic Neoplasms; Humans; Kinetics; Membrane Potentia | 1997 |
Use of replication deficient adenoviruses to investigate the role of G proteins in Ca2+ signalling in epithelial cells.
Topics: Adenoviridae; Calcium Signaling; Carbachol; Carcinoma; Colonic Neoplasms; Epithelial Cells; Genes, D | 1998 |
Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells.
Topics: Carbachol; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Dru | 2000 |
Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells.
Topics: Bombesin; Calcium; Carbachol; Colonic Neoplasms; Humans; Inositol 1,4,5-Trisphosphate; N-Methylscopo | 1992 |
Neurotensin and neuromedin N stimulate mucin output from human goblet cells (Cl.16E) via neurotensin receptors.
Topics: Amino Acid Sequence; Binding, Competitive; Calcium; Carbachol; Colon; Colonic Neoplasms; Cyclic AMP; | 1992 |
Biphasic increase of apical Cl- conductance by muscarinic stimulation of HT-29cl.19A human colon carcinoma cell line: evidence for activation of different Cl- conductances by carbachol and forskolin.
Topics: Calcium; Carbachol; Chloride Channels; Chlorides; Colforsin; Colonic Neoplasms; Cyclic AMP; Humans; | 1992 |
Activation of T84 cell chloride channels by carbachol involves a phosphoinositide-coupled muscarinic M3 receptor.
Topics: Arachidonic Acid; Atropine; Carbachol; Chloride Channels; Chlorides; Colonic Neoplasms; Humans; Ion | 1992 |
Transmitter-induced changes of the membrane voltage of HT29 cells.
Topics: Adenine Nucleotides; Carbachol; Carcinoma; Cell Membrane; Chlorides; Colonic Neoplasms; Culture Medi | 1992 |
Small-conductance Cl- channels in HT29 cells: activation by Ca2+, hypotonic cell swelling and 8-Br-cGMP.
Topics: Adenosine Triphosphate; Calcium; Carbachol; Carcinoma; Chlorides; Colonic Neoplasms; Culture Media; | 1992 |
Intracellular Ca2+ signalling is modulated by K+ channel blockers in colonic epithelial cells (HT-29/B6).
Topics: Atropine; Calcium; Carbachol; Colonic Neoplasms; Epithelial Cells; Epithelium; Humans; Intracellular | 1992 |
Characterization of the synergistic interaction of Escherichia coli heat-stable toxin and carbachol.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bacterial Toxins; Calcium; Carbachol; Carcinoma; Chlorides; | 1991 |
Simultaneous recording of the cell membrane potential and properties of the cell attached membrane of HT29 colon carcinoma and CF-PAC cells.
Topics: Carbachol; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colonic Neoplasms; Electrophysiol | 1991 |
Ca2+ and cAMP activate different chloride efflux pathways in HT-29.cl19A colonic epithelial cell line.
Topics: Biological Transport; Calcimycin; Calcium; Calcium Channel Blockers; Carbachol; Chlorides; Colforsin | 1991 |
A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells.
Topics: Barium; Bumetanide; Carbachol; Cell Line; Charybdotoxin; Chloride Channels; Chlorides; Colforsin; Co | 1990 |
Regulation of calcium-activated potassium efflux by neurotensin and other agents in HT-29 cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Barium; Calcium; Carbachol; Cell Line; Colonic Neoplasms; Hu | 1991 |
Carbachol induces oscillations of membrane potassium conductance in a colonic cell line, T84.
Topics: Calcium; Carbachol; Cell Line; Cell Membrane; Colonic Neoplasms; Egtazic Acid; Electric Conductivity | 1990 |
The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues.
Topics: Adenocarcinoma; Calcimycin; Carbachol; Cell Line; Cholera Toxin; Colonic Neoplasms; Cystic Fibrosis; | 1990 |
Carbachol increases basolateral K+ conductance in T84 cells. Simultaneous measurements of cell [Ca] and gK explore calcium's role.
Topics: Amphotericin B; Calcium; Carbachol; Cell Membrane; Colonic Neoplasms; Egtazic Acid; Electric Conduct | 1990 |
Agonist-induced desensitization of cholinergically stimulated phosphoinositide breakdown is independent of endogenously activated protein kinase C in HT-29 human colon carcinoma cells.
Topics: Carbachol; Colonic Neoplasms; Enzyme Activation; GTP-Binding Proteins; Humans; Hydrolysis; Inositol; | 1990 |
Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells.
Topics: Calcium; Carbachol; Cell Line; Chloride Channels; Chlorides; Colonic Neoplasms; Cytosol; Egtazic Aci | 1989 |
Carbachol-induced cytosolic free Ca2+ increases in T84 colonic cells seen by microfluorimetry.
Topics: Atropine; Calcium; Carbachol; Cell Line; Colonic Neoplasms; Cytosol; Dantrolene; Egtazic Acid; Human | 1989 |
Human HT-29 colon carcinoma cells contain muscarinic M3 receptors coupled to phosphoinositide metabolism.
Topics: Carbachol; Carcinoma; Colonic Neoplasms; Gastric Mucosa; Humans; Inositol Phosphates; Phosphatidylin | 1989 |
Role of calcium in mediating action of carbachol in T84 cells.
Topics: Calcium; Carbachol; Chelating Agents; Chlorides; Colonic Neoplasms; Cyclic AMP; Egtazic Acid; Electr | 1989 |
Human intestinal goblet cells in monolayer culture: characterization of a mucus-secreting subclone derived from the HT29 colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Carbachol; Cell Differentiation; Cell Line; Clone Cells; Colonic Neoplasms; Culture | 1988 |
Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation.
Topics: Adenocarcinoma; Carbachol; Cell Differentiation; Cell Line; Clone Cells; Colonic Neoplasms; Cytoplas | 1987 |