carbachol has been researched along with Bradycardia in 29 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The co-transmitter neuropeptide Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia." | 7.74 | Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. ( Danson, EJ; Heaton, DA; Herring, N; Lokale, MN; Paterson, DJ, 2008) |
| "Carbamylcholine, a nonselective muscarinic receptor agonist, and sabcomeline and xanomeline, functional M(1) receptor-selective agonists with high M(2) receptor affinities, were used to explore the relationship of the M(2) receptor affinity of these agonists to mouse atrial bradycardia and to understand the relationship of the high and low M(2) receptor affinity states to carbamylcholine-induced mouse atrial bradycardia." | 7.71 | Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline. ( Cohen, ML; Stengel, PW, 2001) |
| "The co-transmitter neuropeptide Y (NPY), released during prolonged cardiac sympathetic nerve stimulation, can attenuate vagal-induced bradycardia." | 3.74 | Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. ( Danson, EJ; Heaton, DA; Herring, N; Lokale, MN; Paterson, DJ, 2008) |
| " The metabolite showed to some extent mydriatic effect and protective effect against carbachol-induced bradycardia, but of much shorter durations than glycopyrrolate; it had, however, no effect on resting heart rate." | 3.73 | Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics. ( Bodor, N; Buchwald, P; Ji, F; Mori, N; Wu, J; Wu, WM, 2005) |
| "Carbamylcholine, a nonselective muscarinic receptor agonist, and sabcomeline and xanomeline, functional M(1) receptor-selective agonists with high M(2) receptor affinities, were used to explore the relationship of the M(2) receptor affinity of these agonists to mouse atrial bradycardia and to understand the relationship of the high and low M(2) receptor affinity states to carbamylcholine-induced mouse atrial bradycardia." | 3.71 | Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline. ( Cohen, ML; Stengel, PW, 2001) |
| " The in vivo characterization of SG and SGA, both in mydriasis tests and in prevention of carbachol induced bradycardia, supported its soft nature." | 3.70 | Design, synthesis, and pharmacological evaluation of soft glycopyrrolate and its analog. ( Bodor, N; Huang, F; Ji, F; Juhasz, A; Wu, W, 2000) |
| " The soft anticholinergic methoxycarbonylphenylcyclopentyl-N,N-dimethyltropinium methyl sulfate was as potent as atropine in the prevention of carbachol induced bradycardia; however, its action only lasted up to 15-30 min, compared to 2 h of that of atropine." | 3.70 | Cardiovascular studies on different classes of soft drugs. ( Bodor, N; Juhász, A, 2000) |
| " Carbachol (1 microgram/kg) or physostigmine (50 micrograms/kg) induced a long-lasting increase in blood pressure and a decrease in heart rate in Long-Evans rats whereas no bradycardia was observed in Brattleboro rats, and the pressor response was significantly less than that in Long-Evans rats." | 3.67 | Role of vasopressin in cardiovascular response to central cholinergic stimulation in rats. ( Abe, K; Imai, Y; Minami, N; Munakata, M; Nobunaga, T; Sasaki, S; Sekino, H; Yoshinaga, K; Yumita, S, 1989) |
| "Atropine was not able to increase HR in KO animals." | 1.38 | Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M(2) KO animals. ( Benes, J; Farar, V; Myslivecek, J; Novakova, M; Varejkova, E, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (24.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (58.62) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Fenske, S | 1 |
| Hennis, K | 1 |
| Rötzer, RD | 1 |
| Brox, VF | 1 |
| Becirovic, E | 1 |
| Scharr, A | 1 |
| Gruner, C | 1 |
| Ziegler, T | 1 |
| Mehlfeld, V | 1 |
| Brennan, J | 1 |
| Efimov, IR | 1 |
| Pauža, AG | 1 |
| Moser, M | 1 |
| Wotjak, CT | 1 |
| Kupatt, C | 1 |
| Gönner, R | 1 |
| Zhang, R | 1 |
| Zhang, H | 2 |
| Zong, X | 1 |
| Biel, M | 1 |
| Wahl-Schott, C | 1 |
| Blazer, LL | 1 |
| Storaska, AJ | 1 |
| Jutkiewicz, EM | 1 |
| Turner, EM | 1 |
| Calcagno, M | 1 |
| Wade, SM | 1 |
| Wang, Q | 1 |
| Huang, XP | 1 |
| Traynor, JR | 1 |
| Husbands, SM | 1 |
| Morari, M | 1 |
| Neubig, RR | 1 |
| Qin, M | 1 |
| Liu, X | 1 |
| Liu, T | 1 |
| Wang, T | 1 |
| Huang, C | 1 |
| Cifelli, C | 1 |
| Rose, RA | 1 |
| Voigtlaender-Bolz, J | 1 |
| Bolz, SS | 1 |
| Backx, PH | 1 |
| Heximer, SP | 1 |
| Mabe, AM | 1 |
| Hoover, DB | 1 |
| Steele, SL | 1 |
| Lo, KH | 1 |
| Li, VW | 1 |
| Cheng, SH | 1 |
| Ekker, M | 1 |
| Perry, SF | 1 |
| Fabritz, L | 1 |
| Damke, D | 1 |
| Emmerich, M | 1 |
| Kaufmann, SG | 1 |
| Theis, K | 1 |
| Blana, A | 1 |
| Fortmüller, L | 1 |
| Laakmann, S | 1 |
| Hermann, S | 1 |
| Aleynichenko, E | 1 |
| Steinfurt, J | 1 |
| Volkery, D | 1 |
| Riemann, B | 1 |
| Kirchhefer, U | 1 |
| Franz, MR | 1 |
| Breithardt, G | 1 |
| Carmeliet, E | 1 |
| Schäfers, M | 1 |
| Maier, SK | 1 |
| Carmeliet, P | 1 |
| Kirchhof, P | 1 |
| Benes, J | 1 |
| Varejkova, E | 1 |
| Farar, V | 1 |
| Novakova, M | 1 |
| Myslivecek, J | 1 |
| Ikeda, K | 1 |
| Kobayashi, S | 1 |
| Suzuki, M | 1 |
| Miyata, K | 1 |
| Takeuchi, M | 1 |
| Yamada, T | 1 |
| Honda, K | 1 |
| Hsieh, DJ | 1 |
| Liao, CF | 1 |
| Wu, WM | 1 |
| Buchwald, P | 1 |
| Mori, N | 1 |
| Ji, F | 2 |
| Wu, J | 1 |
| Bodor, N | 4 |
| Tóth-Sarudy, E | 1 |
| Tóth, G | 1 |
| Pallagi, I | 1 |
| Seres, G | 1 |
| Vitális, B | 1 |
| Tapfer, M | 1 |
| Perczel, V | 1 |
| Kurucz, I | 1 |
| Zubovics, Z | 1 |
| Schulz, M | 1 |
| Graefe, T | 1 |
| Stuby, K | 1 |
| Andresen, H | 1 |
| Kupfermann, N | 1 |
| Schmoldt, A | 1 |
| Herring, N | 3 |
| Lokale, MN | 1 |
| Danson, EJ | 1 |
| Heaton, DA | 1 |
| Paterson, DJ | 3 |
| Vidal-Beretervide, K | 1 |
| Monti, JM | 1 |
| Dominguez, R | 1 |
| Trinidad, H | 1 |
| van der Meer, FJ | 1 |
| van der Vijver, JC | 1 |
| Huang, F | 1 |
| Juhasz, A | 2 |
| Wu, W | 1 |
| Stengel, PW | 1 |
| Cohen, ML | 1 |
| Wilson, SJ | 1 |
| Bolter, CP | 1 |
| Zaman, JA | 1 |
| Yamada, M | 1 |
| Sagara, Y | 1 |
| Sagara, T | 1 |
| Mase, T | 1 |
| Kimura, T | 1 |
| Numazawa, T | 1 |
| Fujikawa, T | 1 |
| Noguchi, K | 1 |
| Ohtake, N | 1 |
| Sangster, B | 1 |
| Savelkoul, TJ | 1 |
| Nieuwenhuis, MG | 1 |
| van der Sluys Veer, J | 1 |
| Imai, Y | 1 |
| Abe, K | 1 |
| Sasaki, S | 1 |
| Minami, N | 1 |
| Munakata, M | 1 |
| Yumita, S | 1 |
| Nobunaga, T | 1 |
| Sekino, H | 1 |
| Yoshinaga, K | 1 |
| Méhes, J | 1 |
| Decsi, L | 1 |
| Várszegi, MK | 1 |
| Hideg, H | 1 |
| Hankovszky, OH | 1 |
| Cavero, I | 1 |
| Buckley, JP | 1 |
| Jandhyala, BS | 1 |
| Madill, HD | 1 |
| Stewart, WC | 1 |
| Savoie, ML | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Assess the Safety and Efficacy of Solifenacin (VESIcare) for Improving Urinary and Bladder Functions in Patients Undergoing Radiation Therapy of the Prostate[NCT01777217] | Phase 4 | 8 participants (Actual) | Interventional | 2013-02-28 | Terminated (stopped due to Terminated) | ||
| Pre-Operative Stellate Ganglion to Prevent Post-Operative Atrial Fibrillation[NCT05656170] | 0 participants (Actual) | Interventional | 2023-10-01 | Withdrawn (stopped due to Unable to begin study) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The AUASS score range is 1-7 (mild), 8-19 (moderate) and 20-35 (severe). The AUASS asks 7 questions scored 0-5, the scores are summed for the total score. (NCT01777217)
Timeframe: baseline and 16 weeks
| Intervention | Scores on a scale (Median) |
|---|---|
| Solifenacin Succinate | 9.4 |
| Placebo | 6.7 |
29 other studies available for carbachol and Bradycardia
| Article | Year |
|---|---|
cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Biological Clocks; Blood Pressure; Bradycardia; Ca | 2020 |
Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors.
Topics: Animals; Antiparkinson Agents; Bradycardia; Calcium; Carbachol; Cell Line, Tumor; Cholinergic Agonis | 2015 |
Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia.
Topics: Acetylcholine; Action Potentials; Animals; Bradycardia; Carbachol; Cholinergic Agonists; Disease Mod | 2016 |
RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.
Topics: Action Potentials; Animals; Atropine; Bradycardia; Carbachol; Cardiotonic Agents; Dose-Response Rela | 2008 |
Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice.
Topics: Acetylcholine; Adrenergic Fibers; Animals; Bethanechol; Bradycardia; Carbachol; Cholinergic Agonists | 2009 |
Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio).
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Anta | 2009 |
Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia A | 2010 |
Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M(2) KO animals.
Topics: Animals; Atropine; Bradycardia; Carbachol; Gene Expression Regulation; Heart Rate; Heart Ventricles; | 2012 |
M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland.
Topics: Animals; Benzofurans; Bradycardia; Calcium; Carbachol; Cells, Cultured; Cytosol; Dose-Response Relat | 2002 |
Zebrafish M2 muscarinic acetylcholine receptor: cloning, pharmacological characterization, expression patterns and roles in embryonic bradycardia.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Bradycardia; Carbachol; Cloning, | 2002 |
Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics.
Topics: Administration, Topical; Animals; Bradycardia; Carbachol; Chemical Phenomena; Chemistry, Physical; C | 2005 |
Preparation and biological effects of pure stereoisomeric novel soft anticholinergics.
Topics: Animals; Bradycardia; Carbachol; Cerebral Cortex; Cholinergic Antagonists; Chromatography, Thin Laye | 2006 |
Case report: acute unintentional carbachol intoxication.
Topics: Aged, 80 and over; Atropine; Bradycardia; Carbachol; Fatal Outcome; Heart Arrest; Humans; Male; Musc | 2006 |
Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.
Topics: Acetylcholine; Animals; Arginine; Benzazepines; Bradycardia; Carbachol; Choline O-Acetyltransferase; | 2008 |
Pharmacological studies of bis-scopolammonium-p-xylilene dibromide.
Topics: Animals; Birds; Blood Pressure; Bradycardia; Carbachol; Cats; Central Nervous System; Lacrimal Appar | 1967 |
[Bradycardia and cardiogenic shock caused by carbachol].
Topics: Aged; Atropine; Bradycardia; Carbachol; Female; Humans; Male; Middle Aged; Shock, Cardiogenic | 1982 |
Design, synthesis, and pharmacological evaluation of soft glycopyrrolate and its analog.
Topics: Administration, Topical; Animals; Bradycardia; Carbachol; Eye; Glycopyrrolate; Guinea Pigs; Ileum; I | 2000 |
Cardiovascular studies on different classes of soft drugs.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atropine Der | 2000 |
Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
Topics: Animals; Atropine; Bradycardia; Carbachol; Drug Interactions; Heart; Heart Rate; Imines; In Vitro Te | 2001 |
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbacho | 2001 |
Interaction of the autonomic nervous system with intrinsic cardiac rate regulation in the guinea-pig, Cavia porcellus.
Topics: Animals; Atrial Function; Autonomic Nervous System; Bradycardia; Carbachol; Cardiotonic Agents; Elec | 2001 |
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Bradycardia; Calcium Channel Blockers; Carbachol; | 2001 |
The role of muscarinic K(+) channels in the negative chronotropic effect of a muscarinic agonist.
Topics: Animals; Bee Venoms; Bradycardia; Carbachol; Cesium; Chlorides; Cyclic AMP; Depression, Chemical; Do | 2002 |
Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.
Topics: Acetylcholine; Animals; Bradycardia; Bronchoconstriction; Carbachol; CHO Cells; Cholinergic Agents; | 2002 |
Two cases of carbachol intoxication.
Topics: Adult; Atropine; Bradycardia; Carbachol; Child; Enteritis; Homicide; Humans; Hyperhidrosis; Hypotens | 1979 |
Role of vasopressin in cardiovascular response to central cholinergic stimulation in rats.
Topics: Animals; Arginine Vasopressin; Atropine Derivatives; Autonomic Nervous System; Blood Pressure; Brady | 1989 |
Inhibitory effect of 1-alkylbenzimidazoles on gastric secretion in the rat.
Topics: Acetylcholine; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Carbachol; Cats; Central Nerv | 1966 |
Parasympatholytic activity of (-)- 9 -trans-tetrahydrocannabinol in mongrel dogs.
Topics: Animals; Bradycardia; Cannabis; Carbachol; Chorda Tympani Nerve; Dogs; Dose-Response Relationship, D | 1972 |
Central and peripheral anticholinergic potency of some drugs antagonistic to anticholinesterase poisoning.
Topics: Animals; Antidotes; Atropine; Bradycardia; Carbachol; Central Nervous System; Cholinesterase Inhibit | 1968 |