Page last updated: 2024-11-07

carbachol and Aura

carbachol has been researched along with Aura in 28 studies

Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Research Excerpts

ExcerptRelevanceReference
" Here we investigated the effect of the mAChR agonist carbachol (CCh) and various mAChR antagonists in human cortical slices (from tissue removed during neurosurgical treatment of epilepsy) by intracellular and extracellular recordings."3.78Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex. ( Dehnicke, C; Deisz, RA; Gigout, S; Horn, P; Lehmann, TN; Wierschke, S, 2012)
"We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats."3.67Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986)
" Sigmoid dose-response curves were plotted, and the IC50s were calculated."1.30Comparison of the effects of M1 and M2 muscarinic receptor activation in the absence of GABAergic inhibition in immature rat hippocampal CA3 area. ( Beaucher, J; Harnois, C; Psarropoulou, C, 1998)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19909 (32.14)18.7374
1990's11 (39.29)18.2507
2000's5 (17.86)29.6817
2010's3 (10.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lévesque, M1
Avoli, M1
Kovacs, FE1
Knop, T1
Urbanski, MJ1
Freiman, I1
Freiman, TM1
Feuerstein, TJ1
Zentner, J1
Szabo, B1
Gigout, S1
Wierschke, S1
Lehmann, TN1
Horn, P1
Dehnicke, C1
Deisz, RA1
Konopacki, J2
Eckersdorf, B2
Gołebiewski, H1
Egorov, AV2
Angelova, PR1
Heinemann, U3
Müller, W2
Leschinger, A1
Stabel, J1
Igelmund, P1
Cruickshank, JW1
Brudzynski, SM1
McLachlan, RS1
Dickson, CT1
Alonso, A1
Kim, D1
Jun, KS1
Lee, SB1
Kang, NG1
Min, DS1
Kim, YH1
Ryu, SH1
Suh, PG1
Shin, HS1
Beau, FE1
Alger, BE1
Psarropoulou, C2
Dallaire, F1
Beaucher, J1
Harnois, C1
French, SJ1
Humby, T1
Horner, CH1
Sofroniew, MV1
Rattray, M1
Mraovitch, S1
Calando, Y1
Gloveli, T1
Schmitz, D1
Elazar, Z1
Berchanski, A1
Kowalczyk, T1
Golebiewski, H1
Kumar, P1
Raju, TR1
Cools, AR1
Hendriks, G1
Korten, J1
Gale, K1
Zhong, P1
Miller, LP1
Murray, TF1
Aram, JA1
Martin, D1
Tomczyk, M1
Zeman, S1
Millar, J1
Pohler, G1
Lodge, D1
Yaari, Y1
Jensen, MS1
Sutor, B1
Hablitz, JJ1
Wasterlain, CG2
Farber, DB2
Fairchild, MD1
Nicoletti, F1
Barbaccia, ML1
Iadarola, MJ1
Pozzi, O1
Laird, HE1
Fairchild, D1
Stevens, JR1
Lonsbury-Martin, B1
Reiffenstein, RJ1
Triggle, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885]Phase 26 participants (Anticipated)Interventional2022-08-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for carbachol and Aura

ArticleYear
Carbachol-Induced theta-like oscillations in the rodent brain limbic system: Underlying mechanisms and significance.
    Neuroscience and biobehavioral reviews, 2018, Volume: 95

    Topics: Animals; Carbachol; Cholinergic Agonists; Epilepsy; Limbic System; Neuronal Plasticity; Neurons; Rod

2018
[Electroencephalographic (EEG) activity recorded in brain tissue in vitro].
    Postepy higieny i medycyny doswiadczalnej, 2002, Volume: 56, Issue:3

    Topics: Animals; Carbachol; Electroencephalography; Epilepsy; Hippocampus; Humans; In Vitro Techniques; Limb

2002
Synaptic mechanisms in the kindled epileptic focus: a speculative synthesis.
    Advances in neurology, 1986, Volume: 44

    Topics: Animals; Anticonvulsants; Biomechanical Phenomena; Brain Damage, Chronic; Calcium; Carbachol; Electr

1986
Cholinergic kindling: what has it taught us about epilepsy?
    Journal of neural transmission, 1985, Volume: 63, Issue:2

    Topics: Amygdala; Animals; Brain Damage, Chronic; Carbachol; Epilepsy; Hippocampus; Humans; Kindling, Neurol

1985

Other Studies

24 other studies available for carbachol and Aura

ArticleYear
Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:5

    Topics: Adolescent; Adult; Benzoxazines; Bicuculline; Biophysics; Cannabinoid Receptor Modulators; Cannabino

2012
Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex.
    Neuroscience, 2012, Oct-25, Volume: 223

    Topics: Action Potentials; Adult; Biophysics; Carbachol; Cerebral Cortex; Cholinergic Agonists; Drug Combina

2012
Ca2+-independent muscarinic excitation of rat medial entorhinal cortex layer V neurons.
    The European journal of neuroscience, 2003, Volume: 18, Issue:12

    Topics: Acetylcholine; Action Potentials; Afferent Pathways; Animals; Calcium; Calcium Channel Blockers; Cal

2003
Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices.
    Experimental brain research, 1993, Volume: 96, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Carbachol; Elec

1993
Involvement of M1 muscarinic receptors in the initiation of cholinergically induced epileptic seizures in the rat brain.
    Brain research, 1994, Apr-18, Volume: 643, Issue:1-2

    Topics: Animals; Brain; Brain Mapping; Carbachol; Epilepsy; Male; Microinjections; Rats; Rats, Wistar; Recep

1994
Muscarinic induction of synchronous population activity in the entorhinal cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Sep-01, Volume: 17, Issue:17

    Topics: Animals; Carbachol; Electrophysiology; Entorhinal Cortex; Epilepsy; Glutamic Acid; Male; Muscarine;

1997
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.
    Nature, 1997, Sep-18, Volume: 389, Issue:6648

    Topics: Animals; Ataxia; Binding Sites; Brain; Carbachol; Cerebellum; Cycloleucine; Epilepsy; Hippocampus; I

1997
Transient suppression of GABAA-receptor-mediated IPSPs after epileptiform burst discharges in CA1 pyramidal cells.
    Journal of neurophysiology, 1998, Volume: 79, Issue:2

    Topics: Action Potentials; Animals; Calcium; Carbachol; Epilepsy; Ethylmaleimide; Evoked Potentials; gamma-A

1998
Activation of muscarinic receptors during blockade of GABA(A)-mediated inhibition induces synchronous epileptiform activity in immature rat hippocampus.
    Neuroscience, 1998, Volume: 82, Issue:4

    Topics: Animals; Bicuculline; Carbachol; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampu

1998
Comparison of the effects of M1 and M2 muscarinic receptor activation in the absence of GABAergic inhibition in immature rat hippocampal CA3 area.
    Brain research. Developmental brain research, 1998, May-15, Volume: 107, Issue:2

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Carbacho

1998
Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine.
    Brain research. Molecular brain research, 1999, Apr-06, Volume: 67, Issue:1

    Topics: Acetylcholine; Animals; Behavior, Animal; Brain Chemistry; Brain-Derived Neurotrophic Factor; Carbac

1999
Interactions between limbic, thalamo-striatal-cortical, and central autonomic pathways during epileptic seizure progression.
    The Journal of comparative neurology, 1999, Aug-16, Volume: 411, Issue:1

    Topics: Acetylcholine; Amygdala; Animals; Autonomic Nervous System; Behavior, Animal; Carbachol; Cerebral Co

1999
Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III.
    The European journal of neuroscience, 1999, Volume: 11, Issue:10

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Calcium; Calcium Signali

1999
Excitatory amino acids modulate epileptogenesis in the brain stem.
    Neuroreport, 2000, Jun-05, Volume: 11, Issue:8

    Topics: Animals; Brain Stem; Carbachol; Cholinergic Agonists; Dizocilpine Maleate; Drug Synergism; Epilepsy;

2000
Window effect of temperature on carbachol-induced theta-like activity recorded in hippocampal formation in vitro.
    Brain research, 2001, May-18, Volume: 901, Issue:1-2

    Topics: Action Potentials; Animals; Body Temperature; Carbachol; Cholinergic Agonists; Epilepsy; Hippocampus

2001
Seizure susceptibility decreases with enhancement of rapid eye movement sleep.
    Brain research, 2001, Dec-20, Volume: 922, Issue:2

    Topics: Acetylcholine; Afferent Pathways; Amygdala; Animals; Carbachol; Causality; Cholinergic Agonists; Ele

2001
The acetylcholine-dopamine balance in the basal ganglia of rhesus monkeys and its role in dynamic, dystonic, dyskinetic, and epileptoid motor activities.
    Journal of neural transmission, 1975, Volume: 36, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Basal Ganglia; Carbachol; Caudate Nucleus; Dopamine; Drug Interact

1975
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am

1992
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1

    Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Dextromethorphan; Dose-Response Relationship, Dr

1989
Cholinergic modulation of hippocampal epileptic activity in vitro.
    EXS, 1989, Volume: 57

    Topics: Acetylcholine; Animals; Atropine; Carbachol; Epilepsy; Hexamethonium; Hexamethonium Compounds; Hippo

1989
Cholinergic modulation of epileptiform activity in the developing rat neocortex.
    Brain research. Developmental brain research, 1989, Mar-01, Volume: 46, Issue:1

    Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Cholinergic Fibers; Electric Stimulation; Ep

1989
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
    Journal of neurochemistry, 1986, Volume: 46, Issue:1

    Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam

1986
Limbic system, epilepsy and psychosis: experimental studies and clinical correlations.
    Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa, 1985, Volume: 10, Issue:4

    Topics: Amygdala; Animals; Carbachol; Cats; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kindling, Neurologic;

1985
Sensitivity of denervated cerebral cortex to cholinomimetics.
    Electroencephalography and clinical neurophysiology, 1972, Volume: 33, Issue:2

    Topics: Animals; Atropine; Bethanechol Compounds; Carbachol; Cats; Cerebral Cortex; Cholinesterases; Denerva

1972