carbachol has been researched along with Aura in 28 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we investigated the effect of the mAChR agonist carbachol (CCh) and various mAChR antagonists in human cortical slices (from tissue removed during neurosurgical treatment of epilepsy) by intracellular and extracellular recordings." | 3.78 | Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex. ( Dehnicke, C; Deisz, RA; Gigout, S; Horn, P; Lehmann, TN; Wierschke, S, 2012) |
| "We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats." | 3.67 | Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986) |
| " Sigmoid dose-response curves were plotted, and the IC50s were calculated." | 1.30 | Comparison of the effects of M1 and M2 muscarinic receptor activation in the absence of GABAergic inhibition in immature rat hippocampal CA3 area. ( Beaucher, J; Harnois, C; Psarropoulou, C, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 11 (39.29) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lévesque, M | 1 |
| Avoli, M | 1 |
| Kovacs, FE | 1 |
| Knop, T | 1 |
| Urbanski, MJ | 1 |
| Freiman, I | 1 |
| Freiman, TM | 1 |
| Feuerstein, TJ | 1 |
| Zentner, J | 1 |
| Szabo, B | 1 |
| Gigout, S | 1 |
| Wierschke, S | 1 |
| Lehmann, TN | 1 |
| Horn, P | 1 |
| Dehnicke, C | 1 |
| Deisz, RA | 1 |
| Konopacki, J | 2 |
| Eckersdorf, B | 2 |
| Gołebiewski, H | 1 |
| Egorov, AV | 2 |
| Angelova, PR | 1 |
| Heinemann, U | 3 |
| Müller, W | 2 |
| Leschinger, A | 1 |
| Stabel, J | 1 |
| Igelmund, P | 1 |
| Cruickshank, JW | 1 |
| Brudzynski, SM | 1 |
| McLachlan, RS | 1 |
| Dickson, CT | 1 |
| Alonso, A | 1 |
| Kim, D | 1 |
| Jun, KS | 1 |
| Lee, SB | 1 |
| Kang, NG | 1 |
| Min, DS | 1 |
| Kim, YH | 1 |
| Ryu, SH | 1 |
| Suh, PG | 1 |
| Shin, HS | 1 |
| Beau, FE | 1 |
| Alger, BE | 1 |
| Psarropoulou, C | 2 |
| Dallaire, F | 1 |
| Beaucher, J | 1 |
| Harnois, C | 1 |
| French, SJ | 1 |
| Humby, T | 1 |
| Horner, CH | 1 |
| Sofroniew, MV | 1 |
| Rattray, M | 1 |
| Mraovitch, S | 1 |
| Calando, Y | 1 |
| Gloveli, T | 1 |
| Schmitz, D | 1 |
| Elazar, Z | 1 |
| Berchanski, A | 1 |
| Kowalczyk, T | 1 |
| Golebiewski, H | 1 |
| Kumar, P | 1 |
| Raju, TR | 1 |
| Cools, AR | 1 |
| Hendriks, G | 1 |
| Korten, J | 1 |
| Gale, K | 1 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Aram, JA | 1 |
| Martin, D | 1 |
| Tomczyk, M | 1 |
| Zeman, S | 1 |
| Millar, J | 1 |
| Pohler, G | 1 |
| Lodge, D | 1 |
| Yaari, Y | 1 |
| Jensen, MS | 1 |
| Sutor, B | 1 |
| Hablitz, JJ | 1 |
| Wasterlain, CG | 2 |
| Farber, DB | 2 |
| Fairchild, MD | 1 |
| Nicoletti, F | 1 |
| Barbaccia, ML | 1 |
| Iadarola, MJ | 1 |
| Pozzi, O | 1 |
| Laird, HE | 1 |
| Fairchild, D | 1 |
| Stevens, JR | 1 |
| Lonsbury-Martin, B | 1 |
| Reiffenstein, RJ | 1 |
| Triggle, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for carbachol and Aura
| Article | Year |
|---|---|
Carbachol-Induced theta-like oscillations in the rodent brain limbic system: Underlying mechanisms and significance.
Topics: Animals; Carbachol; Cholinergic Agonists; Epilepsy; Limbic System; Neuronal Plasticity; Neurons; Rod | 2018 |
[Electroencephalographic (EEG) activity recorded in brain tissue in vitro].
Topics: Animals; Carbachol; Electroencephalography; Epilepsy; Hippocampus; Humans; In Vitro Techniques; Limb | 2002 |
Synaptic mechanisms in the kindled epileptic focus: a speculative synthesis.
Topics: Animals; Anticonvulsants; Biomechanical Phenomena; Brain Damage, Chronic; Calcium; Carbachol; Electr | 1986 |
Cholinergic kindling: what has it taught us about epilepsy?
Topics: Amygdala; Animals; Brain Damage, Chronic; Carbachol; Epilepsy; Hippocampus; Humans; Kindling, Neurol | 1985 |
24 other studies available for carbachol and Aura
| Article | Year |
|---|---|
Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex.
Topics: Adolescent; Adult; Benzoxazines; Bicuculline; Biophysics; Cannabinoid Receptor Modulators; Cannabino | 2012 |
Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex.
Topics: Action Potentials; Adult; Biophysics; Carbachol; Cerebral Cortex; Cholinergic Agonists; Drug Combina | 2012 |
Ca2+-independent muscarinic excitation of rat medial entorhinal cortex layer V neurons.
Topics: Acetylcholine; Action Potentials; Afferent Pathways; Animals; Calcium; Calcium Channel Blockers; Cal | 2003 |
Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Carbachol; Elec | 1993 |
Involvement of M1 muscarinic receptors in the initiation of cholinergically induced epileptic seizures in the rat brain.
Topics: Animals; Brain; Brain Mapping; Carbachol; Epilepsy; Male; Microinjections; Rats; Rats, Wistar; Recep | 1994 |
Muscarinic induction of synchronous population activity in the entorhinal cortex.
Topics: Animals; Carbachol; Electrophysiology; Entorhinal Cortex; Epilepsy; Glutamic Acid; Male; Muscarine; | 1997 |
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.
Topics: Animals; Ataxia; Binding Sites; Brain; Carbachol; Cerebellum; Cycloleucine; Epilepsy; Hippocampus; I | 1997 |
Transient suppression of GABAA-receptor-mediated IPSPs after epileptiform burst discharges in CA1 pyramidal cells.
Topics: Action Potentials; Animals; Calcium; Carbachol; Epilepsy; Ethylmaleimide; Evoked Potentials; gamma-A | 1998 |
Activation of muscarinic receptors during blockade of GABA(A)-mediated inhibition induces synchronous epileptiform activity in immature rat hippocampus.
Topics: Animals; Bicuculline; Carbachol; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampu | 1998 |
Comparison of the effects of M1 and M2 muscarinic receptor activation in the absence of GABAergic inhibition in immature rat hippocampal CA3 area.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Carbacho | 1998 |
Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain Chemistry; Brain-Derived Neurotrophic Factor; Carbac | 1999 |
Interactions between limbic, thalamo-striatal-cortical, and central autonomic pathways during epileptic seizure progression.
Topics: Acetylcholine; Amygdala; Animals; Autonomic Nervous System; Behavior, Animal; Carbachol; Cerebral Co | 1999 |
Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Calcium; Calcium Signali | 1999 |
Excitatory amino acids modulate epileptogenesis in the brain stem.
Topics: Animals; Brain Stem; Carbachol; Cholinergic Agonists; Dizocilpine Maleate; Drug Synergism; Epilepsy; | 2000 |
Window effect of temperature on carbachol-induced theta-like activity recorded in hippocampal formation in vitro.
Topics: Action Potentials; Animals; Body Temperature; Carbachol; Cholinergic Agonists; Epilepsy; Hippocampus | 2001 |
Seizure susceptibility decreases with enhancement of rapid eye movement sleep.
Topics: Acetylcholine; Afferent Pathways; Amygdala; Animals; Carbachol; Causality; Cholinergic Agonists; Ele | 2001 |
The acetylcholine-dopamine balance in the basal ganglia of rhesus monkeys and its role in dynamic, dystonic, dyskinetic, and epileptoid motor activities.
Topics: Acetylcholine; Animals; Atropine; Basal Ganglia; Carbachol; Caudate Nucleus; Dopamine; Drug Interact | 1975 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.
Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Dextromethorphan; Dose-Response Relationship, Dr | 1989 |
Cholinergic modulation of hippocampal epileptic activity in vitro.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Epilepsy; Hexamethonium; Hexamethonium Compounds; Hippo | 1989 |
Cholinergic modulation of epileptiform activity in the developing rat neocortex.
Topics: Action Potentials; Animals; Carbachol; Cerebral Cortex; Cholinergic Fibers; Electric Stimulation; Ep | 1989 |
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam | 1986 |
Limbic system, epilepsy and psychosis: experimental studies and clinical correlations.
Topics: Amygdala; Animals; Carbachol; Cats; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kindling, Neurologic; | 1985 |
Sensitivity of denervated cerebral cortex to cholinomimetics.
Topics: Animals; Atropine; Bethanechol Compounds; Carbachol; Cats; Cerebral Cortex; Cholinesterases; Denerva | 1972 |