carbachol has been researched along with Atrial Fibrillation in 29 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 78-year-old woman with bilateral exfoliation glaucoma who was receiving warfarin, 2 mg daily, for systemic anticoagulation developed acute visual loss in the right eye several hours after pupillary dilation." | 7.70 | Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy. ( Greenfield, DS; Liebmann, JM; Ritch, R, 1999) |
| "In order to clarify the mechanisms by which the class Ib antiarrhythmic drug aprindine shows efficacy against atrial fibrillation (AF), we examined the effects of the drug on the repolarizing K+ currents in guinea-pig atrial cells by use of patch-clamp techniques." | 3.70 | Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. ( Nakaya, H; Ohmoto-Sekine, Y; Tamagawa, M; Uemura, H, 1999) |
| "A 78-year-old woman with bilateral exfoliation glaucoma who was receiving warfarin, 2 mg daily, for systemic anticoagulation developed acute visual loss in the right eye several hours after pupillary dilation." | 3.70 | Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy. ( Greenfield, DS; Liebmann, JM; Ritch, R, 1999) |
| "It is well known that amiodarone is effective for the treatment of atrial fibrillation." | 3.69 | Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells. ( Hara, Y; Nakaya, H; Tamagawa, M; Watanabe, Y, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Freudenberger, T | 1 |
| Kranz, B | 1 |
| Lehmann, W | 1 |
| Schäfer, K | 1 |
| Münter, K | 1 |
| Lee, K | 1 |
| Ellinor, PT | 1 |
| Hucker, WJ | 1 |
| Cao, X | 1 |
| Aimoto, M | 1 |
| Fukumoto, M | 1 |
| Nagasawa, Y | 1 |
| Tanaka, H | 1 |
| Takahara, A | 1 |
| Alom, F | 1 |
| Miyakawa, M | 1 |
| Matsuyama, H | 1 |
| Nagano, H | 1 |
| Tanahashi, Y | 1 |
| Unno, T | 1 |
| Voigt, N | 4 |
| Heijman, J | 1 |
| Trausch, A | 2 |
| Mintert-Jancke, E | 1 |
| Pott, L | 1 |
| Ravens, U | 5 |
| Dobrev, D | 5 |
| Odening, KE | 1 |
| Nerbonne, JM | 1 |
| Bode, C | 1 |
| Zehender, M | 1 |
| Brunner, M | 1 |
| Aistrup, GL | 2 |
| Villuendas, R | 1 |
| Ng, J | 2 |
| Gilchrist, A | 1 |
| Lynch, TW | 1 |
| Gordon, D | 2 |
| Cokic, I | 2 |
| Mottl, S | 1 |
| Zhou, R | 1 |
| Dean, DA | 1 |
| Wasserstrom, JA | 2 |
| Goldberger, JJ | 2 |
| Kadish, AH | 2 |
| Arora, R | 2 |
| Rozmaritsa, N | 1 |
| Zimniak, T | 1 |
| Christ, T | 3 |
| Wettwer, E | 3 |
| Matschke, K | 1 |
| Koo, SH | 1 |
| Wakili, R | 1 |
| Heo, JH | 1 |
| Chartier, D | 2 |
| Kim, HS | 1 |
| Kim, SJ | 1 |
| Lee, JW | 1 |
| Qi, XY | 1 |
| Nattel, S | 3 |
| Cha, TJ | 1 |
| Walsh, KB | 1 |
| Tuomi, JM | 1 |
| Tyml, K | 1 |
| Jones, DL | 1 |
| Koduri, H | 1 |
| Browne, S | 1 |
| Arapi, D | 1 |
| Segon, Y | 1 |
| Goldstein, J | 1 |
| Angulo, A | 1 |
| Turker, I | 1 |
| Ai, T | 1 |
| Friedrich, A | 1 |
| Jost, N | 1 |
| Knaut, M | 1 |
| Allessie, M | 1 |
| Schotten, U | 1 |
| Po, SS | 1 |
| Scherlag, BJ | 1 |
| Yamanashi, WS | 1 |
| Edwards, J | 1 |
| Zhou, J | 1 |
| Wu, R | 1 |
| Geng, N | 1 |
| Lazzara, R | 1 |
| Jackman, WM | 1 |
| Nishida, A | 1 |
| Reien, Y | 1 |
| Ogura, T | 2 |
| Uemura, H | 3 |
| Tamagawa, M | 5 |
| Yabana, H | 1 |
| Nakaya, H | 5 |
| Maguy, A | 1 |
| Yeh, YH | 2 |
| Qi, X | 1 |
| Lemola, K | 1 |
| Dubuc, M | 1 |
| Cartier, R | 1 |
| Armour, A | 1 |
| Ting, M | 1 |
| Sakabe, M | 1 |
| Shiroshita-Takeshita, A | 1 |
| Comtois, P | 1 |
| Watanabe, Y | 2 |
| Hara, Y | 2 |
| Ohmoto-Sekine, Y | 1 |
| Greenfield, DS | 1 |
| Liebmann, JM | 1 |
| Ritch, R | 1 |
| Furusawa, Y | 1 |
| Wakimoto, H | 1 |
| Maguire, CT | 2 |
| Kovoor, P | 2 |
| Hammer, PE | 1 |
| Gehrmann, J | 2 |
| Triedman, JK | 1 |
| Berul, CI | 2 |
| Wickman, K | 1 |
| Pu, W | 1 |
| Clapham, DE | 1 |
| Graf, E | 1 |
| Himmel, HM | 1 |
| Hála, O | 1 |
| Doerfel, C | 1 |
| Schüler, S | 1 |
| Chiba, S | 3 |
| Hashimoto, K | 3 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Circumferential vs Ganglionated Plexi Ablation in Patients With Paroxysmal Atrial Fibrillation: A Randomized Study[NCT00671905] | 150 participants (Anticipated) | Interventional | 2008-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for carbachol and Atrial Fibrillation
| Article | Year |
|---|---|
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation.
Topics: Acetylcholine; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbachol; Cells, Cultured; Female | 2010 |
28 other studies available for carbachol and Atrial Fibrillation
| Article | Year |
|---|---|
Identification of two preclinical canine models of atrial fibrillation to facilitate drug discovery.
Topics: Animals; Atrial Fibrillation; Carbachol; Cardiotonic Agents; Disease Models, Animal; Dogs; Dose-Resp | 2021 |
Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Carbachol; Electrophysiological Phenomena; In Vitro | 2018 |
Possible antagonistic effects of the TRPC4 channel blocker ML204 on M
Topics: Animals; Atrial Fibrillation; Carbachol; Japan; Male; Mice; Muscarinic Antagonists; Muscle Contracti | 2018 |
Impaired Na⁺-dependent regulation of acetylcholine-activated inward-rectifier K⁺ current modulates action potential rate dependence in patients with chronic atrial fibrillation.
Topics: Acetylcholine; Action Potentials; Aged; Arrhythmia, Sinus; Atrial Fibrillation; Carbachol; Female; G | 2013 |
In vivo effect of a dominant negative Kv4.2 loss-of-function mutation eliminating I(to,f) on atrial refractoriness and atrial fibrillation in mice.
Topics: Action Potentials; Animals; Atrial Fibrillation; Carbachol; Cardiotonic Agents; Female; Genetic Pred | 2009 |
Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation.
Topics: Action Potentials; Animals; Atrial Fibrillation; Calcium Signaling; Carbachol; Cardiovascular Agents | 2009 |
Role of constitutively active acetylcholine-mediated potassium current in atrial contractile dysfunction caused by atrial tachycardia remodelling.
Topics: Acetylcholine; Animals; Atrial Fibrillation; Bee Venoms; Calcium Channels; Carbachol; Disease Models | 2010 |
A real-time screening assay for GIRK1/4 channel blockers.
Topics: Acetylcholine; Amiloride; Animals; Atrial Fibrillation; Barbiturates; Biological Assay; Biological T | 2010 |
Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse.
Topics: Abnormalities, Multiple; Animals; Atrial Fibrillation; Carbachol; Cardiac Pacing, Artificial; Cardio | 2011 |
Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Carbachol; Cholinergic Agonists; DNA; Dogs; Gene Expression; Genetic T | 2011 |
Gene therapy for AF: A dream too far?
Topics: Animals; Atrial Fibrillation; Carbachol; DNA; Genetic Therapy; GTP-Binding Protein alpha Subunits; H | 2011 |
The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation.
Topics: Acetylcholine; Aged; Atrial Appendage; Atrial Fibrillation; Bee Venoms; Carbachol; Chronic Disease; | 2005 |
Paroxysmal atrial fibrillation: just a matter of nerves?
Topics: Acetylcholine; Animals; Atrial Fibrillation; Carbachol; Dogs; Electrocardiography; Electrophysiologi | 2006 |
Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions.
Topics: Acetylcholine; Animals; Atrial Fibrillation; Carbachol; Dogs; Electrocardiography; Electrophysiologi | 2006 |
Effects of azimilide on the muscarinic acetylcholine receptor-operated K+ current and experimental atrial fibrillation in guinea-pig hearts.
Topics: Action Potentials; Animals; Atrial Fibrillation; Carbachol; Delayed Rectifier Potassium Channels; Do | 2007 |
Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes.
Topics: Acetylcholine; Animals; Atrial Fibrillation; Bee Venoms; Carbachol; Dogs; Female; G Protein-Coupled | 2008 |
Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia.
Topics: Animals; Atrial Fibrillation; Carbachol; Catheter Ablation; Cholinergic Agonists; Disease Models, An | 2008 |
Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbachol; Guin | 1996 |
Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbachol; Disopyramide; El | 1997 |
Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Atrial Fibrillation; Atrial Function; | 1999 |
Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy.
Topics: Aged; Anticoagulants; Atrial Fibrillation; Carbachol; Cerebrovascular Disorders; Drug Therapy, Combi | 1999 |
Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts.
Topics: Action Potentials; Adenosine; Animals; Atrial Fibrillation; Atrial Function; Calcium Channel Blocker | 2000 |
Induction of atrial tachycardia and fibrillation in the mouse heart.
Topics: Animals; Atrial Fibrillation; Autonomic Nervous System; Carbachol; Cardiac Pacing, Artificial; Cardi | 2001 |
Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.
Topics: Animals; Atrial Fibrillation; Carbachol; Cholinergic Agonists; Disease Models, Animal; Electrocardio | 2001 |
Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials.
Topics: Acetylcholine; Action Potentials; Aged; Atrial Fibrillation; Carbachol; Cells, Cultured; Chronic Dis | 2001 |
Sustained atrial fibrillation induced by carbachol, methacholine and bethanechol.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Atrial Fibrillation; Atropine; Bethanechol Comp | 1971 |
Prevention of acetylcholine-induced atrial fibrillation by electric pacing.
Topics: Acetylcholine; Animals; Atrial Fibrillation; Blood Pressure; Carbachol; Female; Heart Rate; Male; Pa | 1974 |
Interruption of atrial fibrillation by pacemaker shift induced by the selective use of noradrenaline into the A-V node artery. (preliminary report).
Topics: Acetylcholine; Animals; Atrial Fibrillation; Carbachol; Coronary Vessels; Dogs; Electrocardiography; | 1968 |