carbachol has been researched along with Anaplastic Astrocytoma in 62 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since the therapeutic efficacy of Li+ in the treatment of mood disorder is observed only after chronic administration, we examined whether long-term Li+ treatment with a therapeutic concentration affected the elevation of intracellular-free Ca2+ concentration ([Ca2+]i) induced by carbachol, a muscarinic receptor agonist, in 1321N1 human astrocytoma cells." | 7.71 | Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C down-regulated human astrocytoma cells. ( Kouno, Si; Kumasaka, T; Kurita, M; Mashiko, H; Nakahata, N; Niwa, Si; Rai, M, 2002) |
| " Histamine H1 receptor-mediated signalling was compared with muscarinic receptor-mediated signalling in 1321N1 human astrocytoma cells." | 7.70 | Discrimination of histamine H1 and muscarinic receptor-mediated signalling pathways by phorbol ester in human astrocytoma cells. ( Kumasaka, T; Kurita, M; Mashiko, H; Nakahata, N; Nakanishi, H; Niwa, S; Ogata, M; Takano, S, 2000) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 7.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| " The effect of mastoparan, a wasp venom toxin, on intracellular free Ca2+ concentration ([Ca2+]i) was examined in human astrocytoma cells." | 7.69 | Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells. ( Ishimoto, H; Mizuno, K; Nakahata, N; Nakanishi, H; Ohizumi, Y, 1994) |
| "In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0." | 7.68 | Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. ( Downes, CP; Sillence, DJ, 1993) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 7.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| " To determine whether such a redistribution of protein kinase C occurs following hormonally stimulated increases in cytoplasmic Ca2+, we measured [3H]phorbol 12,13-dibutyrate ([3H]PDB) binding to protein kinase C in intact 1321N1 astrocytoma cells." | 7.67 | Increases in intracellular Ca2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells. ( Brown, JH; Trilivas, I, 1989) |
| "Intracellular free Ca2+ was monitored in suspensions of 1321N1 astrocytoma cells by using the Ca2+ indicator fura-2." | 7.67 | Desensitization and recovery of muscarinic and histaminergic Ca2+ mobilization in 1321N1 astrocytoma cells. ( Brown, JH; Eubanks, JH; McDonough, PM, 1988) |
| "1-Butanol, which is a substrate for PLD and inhibits PA formation, inhibited carbachol-induced cell proliferation and the underlying intracellular signaling, whereas its analog tert-butanol, which is a poor substrate for PLD, was much less effective." | 5.32 | Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. ( Costa, LG; Guizzetti, M; Kim, Y; Thompson, BD; VanDeMark, K, 2004) |
| " The authors examined the effect of VPA at therapeutic concentrations (300 and 600 microM) on the elevation of intracellular free calcium concentration ([Ca(2+)](i)) induced by carbachol, a muscarinic receptor agonist, in 1321N1 human astrocytoma cells." | 3.74 | Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. ( Kurita, M; Mashiko, H; Nakahata, N; Nishino, S; Niwa, S; Ohtomo, K; Rai, M; Shirakawa, H, 2007) |
| "In 1321N1 astrocytoma cells, carbachol stimulation of M3 muscarinic cholinergic receptors, coupled to phospholipase C, evoked a persistent 10-20-fold activation of p70 S6 kinase (S6K1)." | 3.72 | Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. ( Downes, CP; Proud, CG; Tang, X; Wang, L, 2003) |
| " Carbachol activated NF-kappaB in human 1321N1 astrocytoma cells, as evidenced by translocation of the p65 subunit of NF-kappaB to the nucleus, phosphorylation and degradation of IkappaBalpha in the cytosol, and increase NF-kappaB binding to DNA." | 3.72 | Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol. ( Bordi, F; Costa, LG; Dieguez-Acuña, FJ; Guizzetti, M; Madia, F; Vitalone, A; Woods, JS, 2003) |
| " In 1321N1 human astrocytoma cells, the endogenous PDE1 (identified as PDE1A by reverse transcriptase-PCR) was largely insensitive to Ca2+ released from carbachol-sensitive stores but was robustly stimulated by a similar rise in [Ca2+]i due to carbachol-induced Ca2+ influx." | 3.72 | Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A. ( Ciruela, A; Cooper, DM; Goraya, TA; Masada, N, 2004) |
| " In human astrocytoma 1321N1 cells RGS2 expression was increased by activation of muscarinic receptors coupled to phosphoinositide signaling with carbachol, or by increased cyclic AMP production, demonstrating that both signaling systems can increase the expression of a RGS family member in a single cell type." | 3.71 | Second messengers regulate RGS2 expression which is targeted to the nucleus. ( Cobbs, CS; Harkins, L; Jope, RS; Song, L; Zmijewski, JW, 2001) |
| " In this study, we report on the ability of carbachol to stimulate the phosphorylation of Akt/PKB, an important target of phosphatidylinositol 3 kinase (PI3 kinase) in 1321N1 human astrocytoma cells." | 3.71 | Activation of phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells. ( Costa, LG; Guizzetti, M, 2001) |
| "Since the therapeutic efficacy of Li+ in the treatment of mood disorder is observed only after chronic administration, we examined whether long-term Li+ treatment with a therapeutic concentration affected the elevation of intracellular-free Ca2+ concentration ([Ca2+]i) induced by carbachol, a muscarinic receptor agonist, in 1321N1 human astrocytoma cells." | 3.71 | Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C down-regulated human astrocytoma cells. ( Kouno, Si; Kumasaka, T; Kurita, M; Mashiko, H; Nakahata, N; Niwa, Si; Rai, M, 2002) |
| "The compartmentation of inositol phospholipids was examined by using a combination of radiolabelling approaches in intact and permeabilized 1321N1 astrocytoma cells." | 3.70 | Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells. ( Batty, IH; Currie, RA; Downes, CP, 1998) |
| " Histamine H1 receptor-mediated signalling was compared with muscarinic receptor-mediated signalling in 1321N1 human astrocytoma cells." | 3.70 | Discrimination of histamine H1 and muscarinic receptor-mediated signalling pathways by phorbol ester in human astrocytoma cells. ( Kumasaka, T; Kurita, M; Mashiko, H; Nakahata, N; Nakanishi, H; Niwa, S; Ogata, M; Takano, S, 2000) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 3.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| " The effect of mastoparan, a wasp venom toxin, on intracellular free Ca2+ concentration ([Ca2+]i) was examined in human astrocytoma cells." | 3.69 | Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells. ( Ishimoto, H; Mizuno, K; Nakahata, N; Nakanishi, H; Ohizumi, Y, 1994) |
| "In 1321N1 astrocytoma cells, thrombin, but not carbachol, induces AP-1-mediated gene expression and DNA synthesis." | 3.69 | Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. ( Aragay, AM; Brown, JH; Collins, LR; Goldstein, D; Kennedy, ED; Moskowitz, SA; Post, GR, 1996) |
| "The cholinergic agonist carbachol induced the release of arachidonic acid in the 1321N1 astrocytoma cell line, and this was blocked by atropine, suggesting the involvement of muscarinic receptors." | 3.69 | Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism. ( Alonso, A; Bayon, Y; Garcia-Sancho, J; Hernandez, M; Leslie, C; Nieto, ML; Nuñez, L; Sanchez Crespo, M, 1997) |
| "In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0." | 3.68 | Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. ( Downes, CP; Sillence, DJ, 1993) |
| "In human astrocytoma cells (1321N1), trifluoperazine potently inhibited histamine-induced phosphoinositide hydrolysis, while it slightly inhibited carbachol-induced phosphoinositide hydrolysis." | 3.68 | Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist. ( Ishimoto, H; Kurita, M; Nakahata, N; Ohmori, K; Takahashi, A, 1991) |
| "We have shown previously that the major source of diglyceride (DG) formed following muscarinic receptor (mAChR) stimulation of 1321N1 astrocytoma cells is phosphatidylcholine (PC) rather than the phosphoinositides (Martinson, E." | 3.68 | Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation. ( Brown, JH; Martinson, EA; Trilivas, I, 1990) |
| "Agonist occupation of muscarinic cholinergic receptors of 1321N1 human astrocytoma cells results in an activation of phosphodiesterase and a resultant 50-75% attenuation of isoproterenol-stimulated cyclic AMP accumulation." | 3.67 | Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells. ( Harden, TK; Martin, MW; Tanner, LI; Wells, JN, 1986) |
| "We examined the relationship between phosphatidylcholine (PC) hydrolysis, phosphoinositide hydrolysis, and diacylglycerol (DAG) formation in response to muscarinic acetylcholine receptor (mAChR) stimulation in 1321N1 astrocytoma cells." | 3.67 | Muscarinic receptor activation of phosphatidylcholine hydrolysis. Relationship to phosphoinositide hydrolysis and diacylglycerol metabolism. ( Brown, JH; Goldstein, D; Martinson, EA, 1989) |
| " To determine whether such a redistribution of protein kinase C occurs following hormonally stimulated increases in cytoplasmic Ca2+, we measured [3H]phorbol 12,13-dibutyrate ([3H]PDB) binding to protein kinase C in intact 1321N1 astrocytoma cells." | 3.67 | Increases in intracellular Ca2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells. ( Brown, JH; Trilivas, I, 1989) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 3.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| "Intracellular free Ca2+ was monitored in suspensions of 1321N1 astrocytoma cells by using the Ca2+ indicator fura-2." | 3.67 | Desensitization and recovery of muscarinic and histaminergic Ca2+ mobilization in 1321N1 astrocytoma cells. ( Brown, JH; Eubanks, JH; McDonough, PM, 1988) |
| "Incubation of 1321N1 human astrocytoma cells with carbachol resulted in a rapid loss of binding of [3H]N-methylscopolamine ([3H]NMS) to muscarinic cholinergic receptors measured at 4 degrees C on intact cells; loss of muscarinic receptors in lysates from the same cells measured with [3H]quinuclidinyl benzilate [( 3H]QNB) at 37 degrees C occurred at a slower rate." | 3.67 | Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. ( Harden, TK; Petch, LA; Traynelis, SF; Waldo, GL, 1985) |
| "We compared the abilities of the muscarinic agonist carbachol, epidermal growth factor (EGF), and phorbol 12-myristate 13-acetate (PMA) to induce proto-oncogene mRNA accumulation and other cellular responses in normal and protein kinase C-deficient 1321-N1 human astrocytoma cells." | 3.67 | Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells. ( Blackshear, PJ; Huang, JK; Nemenoff, RA; Spach, DH; Stumpo, DJ, 1987) |
| " The effects of NEM on GTP-sensitive binding of carbachol to muscarinic cholinergic receptors has been compared in a cell line (1321N1 human astrocytoma cells) in which these receptors stimulate phosphoinositide breakdown and in a cell line (NG108-15 neuroblastoma X glioma cells) in which activation of these receptors results in inhibition of adenylate cyclase." | 3.67 | Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni. ( Evans, T; Harden, TK; Martin, MW, 1985) |
| "Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells results in a 40-70% inhibition of isoproterenol- or prostaglandin E1 (PGE1)-stimulated accumulation of cyclic AMP." | 3.66 | Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation. ( Harden, TK; Meeker, RB, 1983) |
| "1-Butanol, which is a substrate for PLD and inhibits PA formation, inhibited carbachol-induced cell proliferation and the underlying intracellular signaling, whereas its analog tert-butanol, which is a poor substrate for PLD, was much less effective." | 1.32 | Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. ( Costa, LG; Guizzetti, M; Kim, Y; Thompson, BD; VanDeMark, K, 2004) |
| "Carbachol caused an increase in phorbol ester binding and translocation of PKCepsilon, however, these were inhibited only by 100-200 mM ethanol." | 1.31 | Muscarinic receptors, protein kinase C isozymes and proliferation of astroglial cells: effects of ethanol. ( Costa, LG; Guizzetti, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (38.71) | 18.7374 |
| 1990's | 18 (29.03) | 18.2507 |
| 2000's | 20 (32.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, X | 2 |
| Wang, L | 1 |
| Proud, CG | 1 |
| Downes, CP | 6 |
| Guizzetti, M | 11 |
| Bordi, F | 1 |
| Dieguez-Acuña, FJ | 1 |
| Vitalone, A | 1 |
| Madia, F | 1 |
| Woods, JS | 1 |
| Costa, LG | 12 |
| Batty, IH | 3 |
| Fleming, IN | 1 |
| Thompson, BD | 1 |
| Kim, Y | 1 |
| VanDeMark, K | 1 |
| Goraya, TA | 1 |
| Masada, N | 1 |
| Ciruela, A | 1 |
| Cooper, DM | 1 |
| Kurita, M | 4 |
| Nishino, S | 1 |
| Ohtomo, K | 1 |
| Rai, M | 2 |
| Shirakawa, H | 1 |
| Mashiko, H | 3 |
| Niwa, S | 2 |
| Nakahata, N | 8 |
| Kreda, SM | 1 |
| Seminario-Vidal, L | 1 |
| Heusden, Cv | 1 |
| Lazarowski, ER | 1 |
| Masters, SB | 4 |
| Harden, TK | 12 |
| Brown, JH | 15 |
| Lazarewicz, JW | 1 |
| Kanje, M | 1 |
| Meeker, RB | 1 |
| Fleischman, LF | 1 |
| Holtzclaw, L | 1 |
| Russell, JT | 1 |
| Mavrothalassitis, G | 1 |
| Fisher, RJ | 1 |
| Nieto, M | 1 |
| Kennedy, E | 1 |
| Goldstein, D | 4 |
| Arias-Montaño, JA | 1 |
| Berger, V | 1 |
| Young, JM | 1 |
| Ishimoto, H | 2 |
| Mizuno, K | 1 |
| Ohizumi, Y | 1 |
| Nakanishi, H | 3 |
| Sillence, DJ | 1 |
| Post, GR | 1 |
| Collins, LR | 1 |
| Kennedy, ED | 1 |
| Moskowitz, SA | 1 |
| Aragay, AM | 1 |
| Bayon, Y | 1 |
| Hernandez, M | 1 |
| Alonso, A | 1 |
| Nuñez, L | 1 |
| Garcia-Sancho, J | 1 |
| Leslie, C | 1 |
| Sanchez Crespo, M | 1 |
| Nieto, ML | 1 |
| Herold, CL | 1 |
| Li, Q | 1 |
| Schachter, JB | 1 |
| Nicholas, RA | 1 |
| Currie, RA | 1 |
| Wei, M | 2 |
| Yost, M | 1 |
| Ogata, M | 1 |
| Kumasaka, T | 2 |
| Takano, S | 1 |
| Catlin, MC | 2 |
| Kavanagh, TJ | 1 |
| Sellers, LA | 1 |
| Simon, J | 1 |
| Lundahl, TS | 1 |
| Cousens, DJ | 1 |
| Humphrey, PP | 1 |
| Barnard, EA | 1 |
| Yagle, K | 1 |
| Lu, H | 2 |
| Möller, T | 1 |
| Zmijewski, JW | 1 |
| Song, L | 1 |
| Harkins, L | 1 |
| Cobbs, CS | 1 |
| Jope, RS | 1 |
| Kouno, Si | 1 |
| Niwa, Si | 1 |
| Gross, RA | 1 |
| Clark, RB | 1 |
| Stephan, CC | 1 |
| Sastry, BV | 1 |
| Takahashi, A | 1 |
| Ohmori, K | 1 |
| Johnson, RA | 1 |
| Toews, ML | 2 |
| Martinson, EA | 2 |
| Trilivas, I | 3 |
| Abe, MT | 1 |
| Trejo, J | 1 |
| Martinson, E | 1 |
| Hoover, RK | 1 |
| Martin, MW | 5 |
| Hughes, AR | 2 |
| Hepler, JR | 2 |
| Tanner, LI | 1 |
| Wells, JN | 1 |
| Stephens, L | 1 |
| Hawkins, PT | 1 |
| Ambler, SK | 1 |
| Thompson, B | 1 |
| Solski, PA | 2 |
| Taylor, P | 1 |
| Orellana, SA | 2 |
| Buss, JE | 1 |
| Quilliam, LA | 1 |
| Evans, T | 2 |
| Quinn, MT | 1 |
| Heng, MM | 1 |
| McDonough, PM | 1 |
| Eubanks, JH | 1 |
| Blackshear, PJ | 1 |
| Stumpo, DJ | 1 |
| Huang, JK | 1 |
| Nemenoff, RA | 1 |
| Spach, DH | 1 |
| Petch, LA | 1 |
| Traynelis, SF | 1 |
| Waldo, GL | 1 |
| Gilman, AG | 1 |
| Nirenberg, M | 1 |
62 other studies available for carbachol and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
Topics: Androstadienes; Astrocytoma; Calcium Signaling; Carbachol; Chelating Agents; Enzyme Activation; Enzy | 2003 |
Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol.
Topics: Astrocytes; Astrocytoma; Atropine; Blotting, Western; Carbachol; Cell Line; Cellular Structures; Cen | 2003 |
Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
Topics: Astrocytoma; Calcium; Carbachol; Cell Line, Tumor; Enzyme Activation; Humans; Inositol 1,4,5-Trispho | 2004 |
Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells.
Topics: 1-Butanol; Astrocytoma; Carbachol; Cell Division; Cell Line, Tumor; Cholinergic Agonists; DNA; Enzym | 2004 |
Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A.
Topics: Adenylyl Cyclases; Astrocytoma; Calcium; Carbachol; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cho | 2004 |
Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells.
Topics: Astrocytoma; Binding, Competitive; Calcium; Carbachol; Cell Line, Tumor; Cell Membrane; Cholinergic | 2007 |
Thrombin-promoted release of UDP-glucose from human astrocytoma cells.
Topics: Actins; Astrocytoma; Calcium; Carbachol; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyt | 2008 |
Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells.
Topics: Astrocytoma; Atropine; Biological Transport, Active; Calcimycin; Calcium; Carbachol; Cell Line; Huma | 1984 |
Effects of neurotransmitters on calcium efflux from cultured glioma cells.
Topics: Astrocytoma; Atropine; Calcium; Calcium Radioisotopes; Carbachol; Cells, Cultured; Cyclic AMP; Cycli | 1981 |
Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation.
Topics: Alprostadil; Astrocytoma; Carbachol; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Humans | 1983 |
ets-1 in astrocytes: expression and transmitter-evoked phosphorylation.
Topics: Alkaloids; Animals; Astrocytes; Astrocytoma; Carbachol; Carbazoles; Cell Differentiation; Cell Line; | 1995 |
Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation.
Topics: Astrocytoma; Carbachol; Chemical Fractionation; Down-Regulation; Enzyme Activation; Ethanol; Glycero | 1994 |
Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices.
Topics: Animals; Astrocytoma; Brain Chemistry; Brain Neoplasms; Calcium; Calcium Channel Blockers; Carbachol | 1994 |
Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells.
Topics: Astrocytoma; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carbachol; Fura-2; GTP-Bin | 1994 |
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
Topics: Astrocytoma; Carbachol; Humans; Inositol; Lithium; Phosphatidylinositols; Propranolol; Tumor Cells, | 1993 |
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.
Topics: Animals; Astrocytes; Astrocytoma; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; COS Cells | 1996 |
Inhibition of muscarinic receptor-stimulated glial cell proliferation by ethanol.
Topics: Acetaldehyde; Acetylcholine; Animals; Astrocytes; Astrocytoma; Bisbenzimidazole; Bromodeoxyuridine; | 1996 |
Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.
Topics: Arachidonic Acid; Astrocytoma; Brain Neoplasms; Calcimycin; Calcium; Carbachol; Carcinogens; Cytosol | 1997 |
Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7.
Topics: Adenine Nucleotides; Animals; Astrocytoma; Carbachol; COS Cells; Cyclic AMP; Enzyme-Linked Immunosor | 1997 |
Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells.
Topics: Astrocytoma; Carbachol; Cell Compartmentation; Cell Membrane Permeability; Cytosol; Guanosine 5'-O-( | 1998 |
The role of protein kinase C alpha and epsilon isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line.
Topics: Astrocytoma; Atropine; Carbachol; Carcinogens; DNA; Dose-Response Relationship, Drug; Down-Regulatio | 1998 |
Exposure to 60-Hz magnetic fields and proliferation of human astrocytoma cells in vitro.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carbachol; Carcinogens; Cell Division; Cerebral Cortex; Choli | 2000 |
Discrimination of histamine H1 and muscarinic receptor-mediated signalling pathways by phorbol ester in human astrocytoma cells.
Topics: Astrocytoma; Brain Neoplasms; Carbachol; Carcinogens; Chelating Agents; Egtazic Acid; Histamine; Hum | 2000 |
Effect of ethanol on muscarinic receptor-induced calcium responses in astroglia.
Topics: Animals; Astrocytes; Astrocytoma; Brain Neoplasms; Calcium; Carbachol; Central Nervous System Depres | 2000 |
Muscarinic receptor-induced calcium responses in astroglia.
Topics: Animals; Astrocytes; Astrocytoma; Calcium; Calcium Signaling; Carbachol; Cells, Cultured; Chelating | 2000 |
Muscarinic receptors, protein kinase C isozymes and proliferation of astroglial cells: effects of ethanol.
Topics: Astrocytes; Astrocytoma; Blotting, Western; Carbachol; Cell Division; Central Nervous System Depress | 2000 |
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Annexin A5; Apoptosis; Astrocytoma; Carbachol; Carbazole | 2001 |
Activation of phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells.
Topics: Androstadienes; Astrocytoma; Carbachol; Cholinergic Agonists; Chromones; Enzyme Inhibitors; Humans; | 2001 |
Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol.
Topics: Animals; Astrocytes; Astrocytoma; Brain; Carbachol; Cell Division; Cholinergic Agonists; DNA; Ethano | 2001 |
Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Calpha.
Topics: Astrocytes; Astrocytoma; Carbachol; Carcinogens; Cell Cycle; Cell Division; Cholinergic Agonists; Cu | 2001 |
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
Topics: Astrocytoma; Calcium Signaling; Carbachol; Enzyme Activation; Humans; Phosphatidylinositol 3-Kinases | 2002 |
Second messengers regulate RGS2 expression which is targeted to the nucleus.
Topics: Astrocytoma; Blotting, Western; Carbachol; Cell Membrane; Cell Nucleus; Colforsin; Cyclic AMP; Cytos | 2001 |
Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C down-regulated human astrocytoma cells.
Topics: Astrocytoma; Binding, Competitive; Calcium; Carbachol; Cell Membrane; Dose-Response Relationship, Dr | 2002 |
Effect of ethanol on protein kinase Czeta and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation.
Topics: Astrocytoma; Carbachol; Cell Division; Cell Line; Cholinergic Agonists; Dose-Response Relationship, | 2002 |
Regulation of adenosine 3',5'-monophosphate content in human astrocytoma cells by isoproterenol and carbachol.
Topics: Adenosine; Ascorbic Acid; Astrocytoma; Calcium; Carbachol; Cell Line; Cyclic AMP; Drug Interactions; | 1977 |
Characterization of the subtype of muscarinic receptor coupled to the stimulation of phosphoinositide hydrolysis in 132-1N1 human astrocytoma cells.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Astrocytoma; Atropine; Carbach | 1992 |
Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist.
Topics: Astrocytoma; Carbachol; Enzyme Activation; Histamine; Histamine H1 Antagonists; Humans; Hydrolysis; | 1991 |
Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Carbachol; Colforsin; Cyclic AMP; | 1990 |
Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation.
Topics: Animals; Astrocytoma; Carbachol; Cell Line; Choline; Diglycerides; Enzyme Activation; Kinetics; Phos | 1990 |
PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cell Division; Cyclic AMP; DNA; GTP-Binding Proteins; Histamine; Humans; Ino | 1990 |
Multiple pathways for signal transduction through the muscarinic cholinergic receptor.
Topics: Animals; Astrocytoma; Calcium; Carbachol; Cell Division; Cell Line; Choline; Ionomycin; Kinetics; Ph | 1990 |
Activation of protein kinase C inhibits internalization and downregulation of muscarinic receptors in 1321N1 human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cycloheximide; Down-Regulation; Enzyme Activation; Humans; N-Methylscopolami | 1990 |
H1-histamine receptors on human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Calcium; Carbachol; Cells, Cultur | 1986 |
Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Astrocytoma; Calcium; Carba | 1986 |
Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate.
Topics: Astrocytoma; Carbachol; Chromatography, High Pressure Liquid; Humans; Phosphatidylinositol Phosphate | 1989 |
Muscarinic receptor activation of phosphatidylcholine hydrolysis. Relationship to phosphoinositide hydrolysis and diacylglycerol metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Astrocytoma; Calcium; Carbachol; Cell Line; Choline; Diglycerid | 1989 |
The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Studies with pirenzepine and McN-A343 in chick heart and astrocytoma cells.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Astrocytoma; Benzodia | 1985 |
Increases in intracellular Ca2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells.
Topics: Astrocytoma; Binding Sites; Bradykinin; Calcium; Carbachol; Cell Membrane; Cytosol; Diglycerides; Et | 1989 |
Receptor-mediated inositol phosphate formation in relation to calcium mobilization: a comparison of two cell lines.
Topics: Animals; Astrocytoma; Calcium; Carbachol; Cell Line; Chromatography, High Pressure Liquid; Inositol | 1987 |
Regulation of phosphoinositide hydrolysis by GTP-binding proteins, phorbol esters and botulinum toxin type D.
Topics: Astrocytoma; Botulinum Toxins; Carbachol; Cell Line; Cholera Toxin; GTP-Binding Proteins; Humans; Hy | 1988 |
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Astrocytoma; Bacterial Toxins; Carbachol; Cell Line; Cel | 1985 |
Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.
Topics: Astrocytoma; Calcium; Carbachol; Cell Line; Chromatography, Ion Exchange; Humans; Hydrolysis; Inosit | 1985 |
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.
Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Humans; Hydrolysis; Phorbol Esters; Phorbols; Phos | 1985 |
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization.
Topics: Animals; Astrocytoma; Calcium; Carbachol; Cells, Cultured; Chick Embryo; GTP-Binding Proteins; Heart | 1985 |
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment.
Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Isoproterenol; Ox | 1986 |
Desensitization and recovery of muscarinic and histaminergic Ca2+ mobilization in 1321N1 astrocytoma cells.
Topics: Astrocytoma; Benzofurans; Calcium; Carbachol; Cytoplasm; Dose-Response Relationship, Drug; Fluoresce | 1988 |
Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cell Line; Epidermal Growth Factor; Humans; Inositol Phosphates; Kinetics; M | 1987 |
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists.
Topics: Astrocytoma; Atropine; Carbachol; Cell Line; Chromatography, High Pressure Liquid; Histamine; Humans | 1987 |
Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cell Membrane; Cells, Cultured; Colforsin; Guanine Nucleotides; Humans; Inos | 1986 |
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Astrocytoma; Bacterial Toxins; Carbachol; Cell Line; | 1985 |
Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.
Topics: Astrocytoma; Atropine; Carbachol; Cell Fractionation; Cell Line; Cell Membrane; Centrifugation, Dens | 1985 |
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aminobutyrates; Animals; Astrocytoma; Car | 1971 |