carbachol has been researched along with Alzheimer Disease in 46 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Excerpt | Relevance | Reference |
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"For patients with Alzheimer's disease, no correlation was obtained between age and S." | 5.28 | [Changes in DNA synthesis in lymphocytes induced by carbachol via muscarinic acetylcholine receptor in relation to aging and Alzheimer's disease in females]. ( Furukawa, Y, 1992) |
" Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 5.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
"The relative proportion of super-high, high and low affinity agonist binding sites was measured in the hippocampus from individuals with dementia of the Alzheimer type (AD/SDAT), mixed (AD-MID) type and controls, using labelled quinuclidinyl benzilate ([3H]QNB) competing with unlabelled carbachol." | 3.67 | Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type. ( Alafuzoff, I; Nordberg, A; Winblad, B, 1986) |
"Carbachol was a chemoattractant for microglia and decreased their phagocytic activity." | 1.43 | The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease. ( Endres, M; Kettenmann, H; Kronenberg, G; Matyash, V; Meier, MA; Pannell, M; Prinz, V; Szulzewsky, F; Waiczies, S; Wolf, SA, 2016) |
"Neurochemical alterations in Alzheimer's disease (AD) include cholinergic neuronal loss in the nucleus basalis of Meynert (nbM) and a decrease in densities of the M2 muscarinic receptor subtype in areas related to learning and memory." | 1.43 | Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease. ( Giménez-Llort, L; LaFerla, FM; Lombardero, L; Manuel, I; Rodríguez-Puertas, R, 2016) |
"The study of late-onset/age-related Alzheimer's disease (AD)(sporadic AD, 95% of AD cases) has been hampered by a paucity of animal models." | 1.42 | Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease. ( Andrew, RD; Bennett, BM; D'Souza, Y; Elharram, A; Soon-Shiong, R, 2015) |
"Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation of inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG)." | 1.33 | Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus. ( Adamczyk, A; Jeśko, H; Strosznajder, RP, 2005) |
"The senile plaque in Alzheimer's disease (AD) consists mainly of the amyloid beta-peptide (A beta) derived from a larger beta-amyloid precursor protein (betaAPP)." | 1.30 | The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells. ( Farlow, MR; Lahiri, DK; Nall, C; Sambamurti, K, 1997) |
"The effects of Alzheimer's disease (AD) on [35S]GTP gamma S binding to G proteins was examined in postmortem cerebrocortex." | 1.29 | Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients. ( Friedman, E; Wang, HY, 1994) |
"For patients with Alzheimer's disease, no correlation was obtained between age and S." | 1.28 | [Changes in DNA synthesis in lymphocytes induced by carbachol via muscarinic acetylcholine receptor in relation to aging and Alzheimer's disease in females]. ( Furukawa, Y, 1992) |
" Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 1.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
"Tacrine was a weak competitor of [3H]phenylisopropyladenosine ([3H]L-PIA) binding in brain membranes." | 1.27 | Blockade of a cardiac K+ channel by tacrine: interactions with muscarinic and adenosine receptors. ( Freeman, SE; Lau, WM; Szilagyi, M, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (15.22) | 18.7374 |
1990's | 21 (45.65) | 18.2507 |
2000's | 11 (23.91) | 29.6817 |
2010's | 7 (15.22) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Dunbar, PG | 1 |
Durant, GJ | 1 |
Rho, T | 1 |
Ojo, B | 1 |
Huzl, JJ | 1 |
Smith, DA | 1 |
el-Assadi, AA | 1 |
Sbeih, S | 1 |
Ngur, DO | 1 |
Periyasamy, S | 1 |
Bromidge, SM | 1 |
Brown, F | 1 |
Cassidy, F | 1 |
Clark, MS | 1 |
Dabbs, S | 1 |
Hadley, MS | 1 |
Hawkins, J | 1 |
Loudon, JM | 1 |
Naylor, CB | 1 |
Orlek, BS | 1 |
Riley, GJ | 1 |
Honarnejad, K | 2 |
Kirsch, AK | 1 |
Daschner, A | 2 |
Szybinska, A | 2 |
Kuznicki, J | 2 |
Herms, J | 2 |
Giese, A | 1 |
Zall, A | 1 |
Schmidt, B | 1 |
Pannell, M | 1 |
Meier, MA | 1 |
Szulzewsky, F | 1 |
Matyash, V | 1 |
Endres, M | 1 |
Kronenberg, G | 1 |
Prinz, V | 1 |
Waiczies, S | 1 |
Wolf, SA | 1 |
Kettenmann, H | 1 |
D'Souza, Y | 1 |
Elharram, A | 1 |
Soon-Shiong, R | 1 |
Andrew, RD | 1 |
Bennett, BM | 1 |
Manuel, I | 1 |
Lombardero, L | 1 |
LaFerla, FM | 1 |
Giménez-Llort, L | 1 |
Rodríguez-Puertas, R | 1 |
Akay, M | 2 |
Wang, K | 2 |
Akay, YM | 2 |
Dragomir, A | 2 |
Wu, J | 2 |
Hicks, DA | 1 |
Makova, NZ | 1 |
Nalivaeva, NN | 1 |
Turner, AJ | 1 |
Muma, NA | 1 |
Mariyappa, R | 1 |
Williams, K | 1 |
Lee, JM | 3 |
Zhong, P | 1 |
Gu, Z | 1 |
Wang, X | 1 |
Jiang, H | 1 |
Feng, J | 1 |
Yan, Z | 1 |
Shiozaki, K | 1 |
Iseki, E | 1 |
Magdesian, MH | 1 |
Nery, AA | 1 |
Martins, AH | 1 |
Juliano, MA | 1 |
Juliano, L | 1 |
Ulrich, H | 1 |
Ferreira, ST | 1 |
Adamczyk, A | 1 |
Jeśko, H | 1 |
Strosznajder, RP | 1 |
Schliebs, R | 1 |
Heidel, K | 1 |
Apelt, J | 1 |
Gniezdzinska, M | 1 |
Kirazov, L | 1 |
Szutowicz, A | 1 |
Warren, NM | 1 |
Piggott, MA | 1 |
Lees, AJ | 1 |
Perry, EK | 2 |
Burn, DJ | 1 |
Lamb, K | 1 |
Bradshaw, CM | 1 |
Szabadi, E | 1 |
Alder, JT | 1 |
Chessell, IP | 2 |
Bowen, DM | 1 |
Ladner, CJ | 2 |
Celesia, GG | 1 |
Magnuson, DJ | 1 |
Ferrari-DiLeo, G | 2 |
Mash, DC | 3 |
Flynn, DD | 4 |
Wolf, BA | 1 |
Wertkin, AM | 1 |
Jolly, YC | 1 |
Yasuda, RP | 1 |
Wolfe, BB | 1 |
Konrad, RJ | 1 |
Manning, D | 1 |
Ravi, S | 1 |
Williamson, JR | 1 |
Lee, VM | 1 |
Cutler, R | 1 |
Joseph, JA | 1 |
Yamagami, K | 1 |
Villalobos-Molina, R | 1 |
Roth, GS | 1 |
Wang, HY | 1 |
Friedman, E | 1 |
Warpman, U | 1 |
Alafuzoff, I | 2 |
Nordberg, A | 2 |
Humphrey, PP | 1 |
Chessell, JP | 1 |
Lahiri, DK | 1 |
Farlow, MR | 1 |
Sambamurti, K | 1 |
Nall, C | 1 |
DeLapp, N | 1 |
Wu, S | 1 |
Belagaje, R | 1 |
Johnstone, E | 1 |
Little, S | 1 |
Shannon, H | 1 |
Bymaster, F | 1 |
Calligaro, D | 1 |
Mitch, C | 1 |
Whitesitt, C | 1 |
Ward, J | 1 |
Sheardown, M | 1 |
Fink-Jensen, A | 1 |
Jeppesen, L | 1 |
Thomsen, C | 1 |
Sauerberg, P | 1 |
Fowler, CJ | 1 |
Tiger, G | 1 |
Forlenza, OV | 1 |
Spink, JM | 1 |
Dayanandan, R | 1 |
Anderton, BH | 1 |
Olesen, OF | 1 |
Lovestone, S | 1 |
Pettit, DL | 1 |
Shao, Z | 1 |
Yakel, JL | 1 |
Cedazo-Mínguez, A | 1 |
Hamker, U | 1 |
Meske, V | 1 |
Veh, RW | 1 |
Hellweg, R | 1 |
Jacobi, C | 1 |
Albert, F | 1 |
Cowburn, RF | 1 |
Ohm, TG | 1 |
Nitsch, RM | 1 |
Slack, BE | 1 |
Wurtman, RJ | 1 |
Growdon, JH | 1 |
Furukawa, Y | 1 |
Weinstein, DA | 1 |
Fulop, T | 1 |
Kekessy, D | 1 |
Foris, G | 1 |
Smith, CJ | 1 |
Court, JA | 1 |
Perry, RH | 1 |
Araujo, DM | 2 |
Lapchak, PA | 2 |
Collier, B | 1 |
Quirion, R | 2 |
Rinne, JO | 1 |
Lönnberg, P | 1 |
Marjamäki, P | 1 |
Rinne, UK | 1 |
Freeman, SE | 1 |
Lau, WM | 1 |
Szilagyi, M | 1 |
Robitaille, Y | 1 |
Gauthier, S | 1 |
Winblad, B | 1 |
1 review available for carbachol and Alzheimer Disease
Article | Year |
---|---|
N-[3H]methylcarbamylcholine binding sites in the rat and human brain: relationship to functional nicotinic autoreceptors and alterations in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain Chemistry; Carbachol; Humans; Radioligand Assay; Rats; Receptors, | 1989 |
45 other studies available for carbachol and Alzheimer Disease
Article | Year |
---|---|
Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Drug Design; Humans; In Vitro Techniques; Indicators an | 1994 |
Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.
Topics: Alzheimer Disease; Animals; Binding Sites; Blood Pressure; Brain; CHO Cells; Cricetinae; Electroence | 1997 |
FRET-based calcium imaging: a tool for high-throughput/content phenotypic drug screening in Alzheimer disease.
Topics: Alzheimer Disease; Bacterial Proteins; Calcium Signaling; Calmodulin-Binding Proteins; Carbachol; Dr | 2013 |
Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Calcium; Calcium Channels; Carbachol; Cell Line; Drug Disc | 2013 |
The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Carbachol; Disease Models, Animal; Female; Glioma; Macrophages; M | 2016 |
Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease.
Topics: Aging; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Alzheimer Disease; | 2015 |
Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Autoradiography; Brain; Carbachol; Disease Models, Animal; Diseas | 2016 |
Nonlinear dynamical analysis of carbachol induced hippocampal oscillations in mice.
Topics: Age Factors; Alzheimer Disease; Animals; Carbachol; Cholinergic Agonists; Disease Models, Animal; El | 2009 |
Decoding state transitions in hippocampal oscillatory activity in mice.
Topics: Alzheimer Disease; Animals; Carbachol; Disease Models, Animal; Hippocampus; Markov Chains; Mice; Mic | 2010 |
Characterisation of acetylcholinesterase release from neuronal cells.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Atropine; Butyrylcholinesterase; Carbachol; Cell L | 2013 |
Differences in regional and subcellular localization of G(q/11) and RGS4 protein levels in Alzheimer's disease: correlation with muscarinic M1 receptor binding parameters.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Brain; Brain Chemistry; Carbachol; Case-Control | 2003 |
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Carbachol; Disease Mo | 2003 |
Decrease in GTP-sensitive high affinity agonist binding of muscarinic acetylcholine receptors in autopsied brains of dementia with Lewy bodies and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Autopsy; Binding, Competitive; Bra | 2004 |
Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid beta.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Carbachol; Cholinergic Agoni | 2005 |
Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Channel Blockers; Calcium Channels; Carba | 2005 |
Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Topics: Acetylcholinesterase; Alzheimer Disease; Carbachol; Cholinergic Agonists; Dose-Response Relationship | 2006 |
Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias.
Topics: Alzheimer Disease; Atropine; Autoradiography; Carbachol; Cerebral Cortex; Dementia; Humans; Lewy Bod | 2008 |
The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia.
Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Choline; Dementia; Dose-Response Relationship, Dru | 1983 |
A neurochemical approach for studying response to acetylcholine in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Biomarkers; Carbachol; Cholinergic Agents; Frontal Lobe; | 1995 |
Regional alterations in M1 muscarinic receptor-G protein coupling in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Binding Sites; Brain; Carbachol; Frontal Lobe; GTP-Binding Proteins; Humans | 1995 |
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; | 1995 |
Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Carbachol; Enzyme Activation; Humans; Neurons; Pr | 1995 |
Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Carbachol; Enzyme Activation; GTP Phosphohydrolas | 1994 |
Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Biotransformation; Brain Chemistry; Carbachol; Female; GTP-Binding Proteins | 1994 |
Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Binding, Competitive; Carbachol; Cell Membrane; Choline O-Acetyltransferase | 1993 |
Coupling of muscarinic receptors to GTP proteins in postmortem human brain--alterations in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Binding, Competitive; Brain; Carbachol; Female; | 1993 |
Nicotinic and muscarinic receptor-evoked depolarizations recorded from a novel cortical brain slice preparation.
Topics: Alzheimer Disease; Animals; Carbachol; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Dose-Resp | 1995 |
Acetylcholine receptor targets on cortical pyramidal neurones as targets for Alzheimer's therapy.
Topics: Alzheimer Disease; Autoradiography; Carbachol; Cerebral Cortex; Electrophysiology; Glycoproteins; Hu | 1996 |
The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Carbachol; Cholinesterase Inhibitors; Culture Med | 1997 |
Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blotting, Western | 1998 |
The sulphydryl oxidizing reagent diamide affects phosphoinositide-mediated signal transduction: implications for the pathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blood Platelets; Brain; Calcium Signaling; Carbachol; Diamide; Dithiothr | 1998 |
Reduced high-affinity agonist binding at the M(1) muscarinic receptor in Alzheimer's disease brain: differential sensitivity to agonists and divalent cations.
Topics: Acetylcholine; Aged; Alzheimer Disease; Brain; Carbachol; Cations, Divalent; Chlorides; Edetic Acid; | 1999 |
Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Binding Sites; Calcium-Ca | 2000 |
beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Carbachol; Cognition Disorders; Do | 2001 |
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Bucladesine; Carbachol; | 2001 |
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Atropine; Blotting, Western; Brain Che | 1992 |
[Changes in DNA synthesis in lymphocytes induced by carbachol via muscarinic acetylcholine receptor in relation to aging and Alzheimer's disease in females].
Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Cells, Cultured; DNA; Female; Humans; Lymphocytes; | 1992 |
Loss of high-affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: implications for the failure of cholinergic replacement therapies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbachol; Choline O-Acetyltransferase; Female; Frontal | 1991 |
Altered post-receptorial signal transduction mechanism under various stimulation in polymorphonuclear granulocytes of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Carbachol; Cyclic AMP; Cyclic GMP; Enkephalin, Me | 1990 |
Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Carbachol; Choline O-Acetyltrans | 1990 |
Brain muscarinic receptor subtypes are differently affected in Alzheimer's disease and Parkinson's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbachol; Choline O-Acetyltransferase; Cholinerg | 1989 |
Blockade of a cardiac K+ channel by tacrine: interactions with muscarinic and adenosine receptors.
Topics: Action Potentials; Adenosine; Alzheimer Disease; Aminoacridines; Animals; Carbachol; Guinea Pigs; He | 1988 |
Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbachol; Cerebral Cortex; Cholin | 1988 |
Characterization of L-[3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Carbachol; Cerebral Cortex; Choli | 1986 |
Muscarinic receptor subtypes in hippocampus in Alzheimer's disease and mixed dementia type.
Topics: Aged; Alzheimer Disease; Carbachol; Dementia; Female; Hippocampus; Humans; Male; Quinuclidinyl Benzi | 1986 |