capuramycin and Tuberculosis

capuramycin has been researched along with Tuberculosis* in 1 studies

Other Studies

1 other study(ies) available for capuramycin and Tuberculosis

Article	Year
Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 New delivery vehicles and routes of delivery were developed for the capuramycin analogue SQ641. While this compound has remarkable in vitro potency against Mycobacterium tuberculosis, it has low solubility in water and poor intracellular activity. We demonstrate here that SQ641 dissolved in the water-soluble vitamin E analogue alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) or incorporated into TPGS-micelles has significant activity in a mouse model of tuberculosis. Topics: Aminoglycosides; Animals; Antitubercular Agents; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Solubility; Tuberculosis; Vitamin E	2009

Article

Year

Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis.

Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

New delivery vehicles and routes of delivery were developed for the capuramycin analogue SQ641. While this compound has remarkable in vitro potency against Mycobacterium tuberculosis, it has low solubility in water and poor intracellular activity. We demonstrate here that SQ641 dissolved in the water-soluble vitamin E analogue alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) or incorporated into TPGS-micelles has significant activity in a mouse model of tuberculosis.

Topics: Aminoglycosides; Animals; Antitubercular Agents; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Solubility; Tuberculosis; Vitamin E

2009