capsaicin has been researched along with Ache in 1221 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 76 (6.22) | 18.7374 |
| 1990's | 226 (18.51) | 18.2507 |
| 2000's | 477 (39.07) | 29.6817 |
| 2010's | 337 (27.60) | 24.3611 |
| 2020's | 105 (8.60) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, Z; Hammock, BD; Hwang, SH; Lee, KS; Li, X; Morisseau, C; Wagner, K; Xu, J; Yang, J | 1 |
| Dai, Y; Kogure, Y; Mabuchi, M; Nakao, S; Noguchi, K; Shimizu, T; Tanaka, A; Wang, S | 1 |
| Gao, J; Guo, Y; Hu, X; Huang, H; Jin, Z; Li, Z; Liu, Z; Wang, K; Wang, Y; Zhang, L; Zhong, Y; Zong, X | 1 |
| Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY | 1 |
| Capim, SL; Carvalho, VAN; Côrtes, WDS; de Carvalho Cid, G; Fernandes, TFDC; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, JM; Vasconcellos, MLAA | 1 |
| Zygmunt, P | 1 |
| Bang, S; He, Q; Ji, J; Ji, RR; Luo, X; Matsuoka, Y; McGinnis, A; Nackley, AG | 1 |
| Akman, M; Aliyev, E; Erin, N; Korcum, AF; Tanrıöver, G | 1 |
| Andersen, OK; Arendt-Nielsen, L; Hugosdottir, R; Kasting, M; Mørch, CD | 1 |
| Fischer, MJM; Reeh, PW | 1 |
| Lei, F; Yan, Z | 1 |
| Engel, P; Flauaus, C; Lu, R; Lukowski, R; Petersen, J; Ruth, P; Schmidtko, A; Zhou, F | 1 |
| Lezmi, S; Maignel, J; Martin, V; Nicoleau, C; Retailleau, K | 1 |
| Brown, KC; Cox, AJ; Dasgupta, P; Finch, PT; Hess, JA; Merritt, JC; Miles, SL; Moles, EG; Richbart, SD; Tirona, MT; Valentovic, MA | 1 |
| Alleleyn, AME; Conchillo, JM; Csekő, K; Helyes, Z; Kajtár, B; Keszthelyi, D; Masclee, AAM; Rinsma, NF; Winkens, B | 1 |
| Pasierski, M; Szulczyk, B | 1 |
| Darré, L; Domene, C; Gonzalez-Resines, S; Oakes, V | 1 |
| Chen, Z; Escamilla-Rivera, V; Jung, S; LaMotte, RH; Malewicz, NM; Oeck, S; Rattray, Z; Tang, X; Zhou, J | 1 |
| Guan, L; Li, J; Zhang, X | 1 |
| Cho, A; Chung, MK; Hall, BE; Kulkarni, AB; Limaye, AS; Wang, S | 1 |
| Burton, S; Cardon, B; Cleary, D | 1 |
| Borghi, SM; Brasil-Silva, L; Casagrande, R; Chichorro, JG; Cunha, JM; Fattori, V; Ferraz, CR; Verri, WA; Zaninelli, TH | 1 |
| Berg, KA; Chavera, TS; Clarke, WP; Jamshidi, RJ; Jennings, EM; LoCoco, PM; Smith, HR; Sullivan, LC | 1 |
| Li, J; Liu, D; Ma, C; Wang, G; Zhang, Z; Zhong, X | 1 |
| Arévalo, JC; Cañada-García, D; Martín-Zanca, D; Sánchez-Sánchez, J; Vicente-García, C | 1 |
| Li, W; Li, Z; Liu, P; Meng, J | 1 |
| Basedau, H; Jürgens, T; May, A; Ortlieb, L; Peng, KP | 1 |
| Alexander, B; Baskaran, P; Bennis, J; Gustafson, N; Louis, S; Mohandass, A; Nemenov, MI; Premkumar, LS; Thyagarajan, B | 1 |
| Hu, L; Li, X; Lou, W; Peng, W; Tong, RK; Zhang, W | 1 |
| Cirilli, I; Dludla, PV; Hanser, S; Jack, B; Mabhida, SE; Marcheggiani, F; Mazibuko-Mbeje, SE; Nkambule, BB; Ntamo, Y; Nyambuya, TM; Ziqubu, K | 1 |
| Bishnoi, M; Chopra, K; Devi, K; Khan, R; Kondepudi, KK; Kumar, A; Kumar, V; Rajarammohan, S; Singh, RP | 1 |
| Cai, M; Ding, Y; Li, H; Li, S; Li, Y; Sun, Q; Xie, W; Zhang, Y | 1 |
| Dong, L; Liang, Q; Liu, Y; Qiao, Z; Shao, L; Wang, K; Zhou, Q | 1 |
| De Petrocellis, L; Moriello, AS; Vitale, RM | 1 |
| Lee, DH; Lee, JJ; Lee, S; Woo, CW | 1 |
| Ma, H; Mao, R; Tang, Y; Yan, H; Zhang, Y; Zhao, Y | 1 |
| Duport, A; Léonard, G; Martel, M; Pelletier, R | 1 |
| Bakreen, A; Giniatullin, R; Jolkkonen, J; Krivoshein, G; Malm, T; van den Maagdenberg, AMJM | 1 |
| Garcia-Larrea, L; Hagiwara, K; Perchet, C; Salameh, C | 1 |
| Albertson, DG; Janal, MN; Nicholson, SJ; Sawicki, CM; Schmidt, BL; Wu, AK | 1 |
| Anuntrangsee, T; Fabi, S; Kungvalpivat, P; Palakornkitti, P; Tanratana, P; Vachiramon, V; Yeesibsean, N | 1 |
| Baad-Hansen, L; Gøkhan, MA; Sørensen, ES | 1 |
| Berger, E; Binshtok, AM; Davidson, E; Edvardson, S; Elpeleg, O; Ghazalin, S; Katz, B; Kfir-Erenfeld, S; Lev, S; Maayan, C; Minke, B; Peters, M; Zaguri, R | 1 |
| Bian, Y; Brabenec, L; Gross, ER; He, S; Hell, RC; Hung, B; Luo, Z; McAllister, SL; Rwere, F; Sinharoy, P; Stary, CM; Stein Neto, B; Svensson, KJ; Wagner, NM; Wu, C; Xu, L; Yu, X; Zambelli, VO; Zhang, Y; Zhao, M | 1 |
| Liu, Q; Lu, YN; Shi, XM; Tian, J; Zhou, LD | 1 |
| Lin, JJ; Qi, YK; Song, XZ; Sun, JY; Xie, YK; Xu, ZZ; Yang, F; Zhang, BL; Zhang, H | 1 |
| Demaree, IS; Ludwig, N; Movila, A; Nichols, FC; Nusbaum, A; Obukhov, AG; White, FA; Yamada, C | 1 |
| Abelson, KSP; Kanui, TI; Makau, CM; Towett, PK | 1 |
| Basedau, H; Gundelwein Silva, E; May, A; Oppermann, T; Peng, KP | 1 |
| Chung, MK; Li, T | 1 |
| Baek, M; Cho, EH; Jang, W; Kim, C; Oh, M | 1 |
| Alsalem, M; Barakat, NA; El-Salem, K; Haddad, M; Jaffal, SM; Saleh, T | 1 |
| Kringel, D; Lötsch, J; Mayer, B | 1 |
| Heffernan, SM; Jeffries, O; John, K; Page, J; Peel, J; Tallent, J; Waldron, M | 1 |
| Auffray, C; Barbosa Bomfim, CC; Barry Delongchamps, N; Bomsel, M; Cohen, E; Ganor, Y; Mariotton, J; Zerbib, M; Zhu, A | 1 |
| Aarab, G; Abbasnejad, M; Esmaeili-Mahani, S; Lobbezoo, F; Raoof, M; Torkzadeh-Mahani, S | 1 |
| Arai, I; Saito, S; Takahashi, K; Takeda, H; Tsuji, M | 1 |
| Helyes, Z; Szőke, É | 1 |
| Akiyama, T; Bystrom, L; Ishida, H; Markan, A; Pavlenko, D; Todurga Seven, Z; Verpile, R | 1 |
| Egharevba, T; Gritsenko, K; Landrum, O; Marcondes, L | 1 |
| Boye Larsen, D; Graven-Nielsen, T; Gregoret, L; Wittkopf, PG | 1 |
| Engelmann, C; Kumar, P; Wang, J | 1 |
| Baad-Hansen, L; List, T; Pigg, M; Pillai, RS; Svensson, P | 1 |
| Bäumer, W; Fukuyama, T; Ganchingco, JRC; Yoder, JA | 1 |
| Ferreiros, N; Geisslinger, G; Lötsch, J; Oertel, BG; Rossmanith, T; Walter, C; Wolters, M; Zinn, S; Zunftmeister, M | 1 |
| Kittaka, H; Tominaga, M; Yamanoi, Y | 1 |
| Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
| Han, Y; Hu, J; Kamau, PM; Lai, R; Luo, A; Luo, L; Tian, Y; Yao, Z; Zheng, J | 1 |
| Bao, C; Dong, XW; Gao, J; Gu, Y; Wang, C | 1 |
| Andersen, EOL; Fischer, L; Gaspar, JC; Guilhen, VA; Lazzarim, MK; Polato, JJ; Sardi, NF; Tobaldini, G | 1 |
| Ahn, S; Ann, J; Bahrenberg, G; Blumberg, PM; Christoph, T; Frank-Foltyn, R; Ha, H; Kim, MS; Kim, YH; Kim, YS; Lee, J; Stockhausen, H; Yoo, YD | 1 |
| Andersen, HH; Graven-Nielsen, T; Hoeger Bement, M; Petersen, KK; Sørensen, LB | 1 |
| Artico, M; Giacomoni, C; Lattanzi, R; Maftei, D; Severini, C; Vellani, V | 1 |
| Demir, E; Holt, S; Şenel, E | 1 |
| Acampora, G; Arout, CA; DeNegre, D; Koretski, J; Newcomb, J; Perrino, AC; Petrakis, IL; Ralevski, E | 1 |
| Lu, ST; Yu, Y | 1 |
| Campbell, JN; Hanson, PD; Stevens, RM | 1 |
| Basra, M; Chan, C; Gomes, S; Hughes, SW; Parr, C; Strutton, PH; Wong, F | 1 |
| Bruehl, S; Campbell, CM; Colloca, L; Dildine, TC; Letzen, JE; Mun, CJ | 1 |
| Abbasnejad, M; Haghdoost-Yazdi, H; Kooshki, R; Raoof, M; Sofiabadi, M | 1 |
| Cai, G; Huang, S; Li, R; Li, Y; Wang, K; Wu, W | 1 |
| Baumgärtner, U; C Rosenberger, D; Greffrath, W; Henrich, F; Magerl, W; Shabes, P; Treede, RD | 1 |
| Inoue, S; Ishida, R; Kaido, M; Kawashima, M; Nakamura, S; Tsubota, K | 1 |
| Braga Ferreira, LG; Dos Santos, JPS; Faria, JV; Faria, RX | 1 |
| Cabeça, LF; Costa, JSR; Couto, VM; Franco, MKKD; Franz-Montan, M; Geraldes, DC; Oliveira-Nascimento, L; Paula, E; Riske, KA; Yokaychiya, F | 1 |
| Curt, A; Hubli, M; Rosner, J; Scheuren, PS | 1 |
| Abubakar, AB; Bautista, TG; Dimmock, MR; Farrell, MJ; Mazzone, SB | 1 |
| Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH | 1 |
| Dorocka-Bobkowska, B; Lukaszewska-Kuska, M; Ślebioda, Z | 1 |
| Frenette, PS; Gulinello, M; Xu, C | 1 |
| Zubcevic, L | 1 |
| Doherty, M; Fernandes, G; Persson, MSM; Sarmanova, A; Stocks, J; Walsh, DA; Zhang, W | 1 |
| Lai, YE; Lascelles, BDX; Marcus, KL; Nolan, MW; Price, ML; Robertson, JB | 1 |
| Čeko, M; Kim, HJ; Kim, SG; Lee, JJ; Lee, SA; Park, BY; Park, H; Roy, M; Wager, TD; Woo, CW | 1 |
| Claeson, AS; Glas, B | 1 |
| Fang, Y; Ma, C; Tao, J; Wang, T | 1 |
| Andersen, HH; Arendt-Nielsen, L; Christensen, JD; Elberling, J; Lo Vecchio, S | 1 |
| de Sousa Valente, J; Hui, VCC; La Montanara, P; Li, T; Nagy, I; Saad, D; Wang, G | 1 |
| Hong, JI; Hwang, HS; Kim, HA; Kim, JR; Park, IY | 1 |
| Alhouayek, M; Ben Kouidar, Y; Buisseret, B; Guillemot-Legris, O; Muccioli, GG; Paquot, A | 1 |
| Johnson, J; Kalyaanamoorthy, S; Light, P; Long, W | 1 |
| Gladkikh, IN; Kozlov, SA; Leychenko, EV; Sintsova, OV | 1 |
| Belboukhari, N; Cheriti, A; Ould El Hadj-Khelil, A; Seddiki, LS; Sekkoum, K; Sulaiman, MR | 1 |
| Baudouin, C; Fakih, D; Guerrero-Moreno, A; Parsadaniantz, SM; Réaux-Le Goazigo, A | 1 |
| Evers, S; Frese, A; Summ, O | 1 |
| Amiri, M; Duarte, FCK; Evans, V; Koh, RGL; Kumbhare, D; Linde, L | 1 |
| Wallace, MS | 1 |
| Gao, M; Hu, J; Qian, H; Qiao, Z; Wang, Q; Wang, Y; Yan, L; Zhang, W; Zhang, Y | 1 |
| Hoffmann, J; Renton, T; Smith, JG; Tan, HL | 1 |
| Barker, AJ; Debus, K; Lewin, GR; Park, TJ; Reznick, J; Smith, ESJ | 1 |
| Misery, L; Orliaguet, M | 1 |
| Able, J; Altmann, S; Berry, LM; Boezio, AA; Boezio, C; Butler, JR; Chu-Moyer, M; Cooke, M; DiMauro, EF; Dineen, TA; Feric Bojic, E; Foti, RS; Fremeau, RT; Gao, H; Graceffa, RF; Gunaydin, H; Guzman-Perez, A; Huang, H; Huang, L; Ilch, C; Jarosh, M; Kornecook, T; Kreiman, CR; La, DS; Ligutti, J; Lin, MJ; Marx, IE; Milgram, BC; Moyer, BD; Nguyen, HN; Peterson, EA; Rescourio, G; Roberts, J; Schenkel, L; Shimanovich, R; Sparling, BA; Stellwagen, J; Taborn, K; Vaida, KR; Wang, J; Weiss, MM; Yeoman, J; Yu, V; Zhu, D | 1 |
| Arulsamy, N; Baskaran, M; Baskaran, P; Thyagarajan, B | 1 |
| Bertelsen, MF; James, LE; Wang, T; Williams, CJ | 1 |
| Dalton, N; Elwood, RW; Riddell, G | 1 |
| Frutiger, K; Heininger, A; Light, A; Wessman, K; White, RJ | 1 |
| Bishnoi, M; Chopra, K; Kaur, IP; Puri, S; Rishi, P; Sharma, G | 1 |
| Lei, J; Pertovaara, A; Wu, JT; Ye, G; You, HJ | 1 |
| Alkhatib, O; Andersson, DA; Bevan, S; Gentry, C; Quallo, T | 1 |
| Ábrahám, IM; Barabás, K; Bölcskei, K; Cseko, K; Ernszt, D; Helyes, Z; Payrits, M; Pohóczky, K; Sághy, É; Szoke, É; Szolcsányi, J | 1 |
| Fahey, E; Gandhi, W; Nadeau, C; Price, RC; Qu, A; Schweinhardt, P; Stone, L; Tarnavskiy, R | 1 |
| de la Roche, J; Eberhardt, EM; Eberhardt, MJ; Echtermeyer, F; Herzog, C; Leffler, A; Risser, L; Schillers, F | 1 |
| Arendt-Nielsen, L; Cairns, BE; Wang, K; Zhang, Y | 1 |
| Aurelio, L; Bunnett, NW; Cai, Z; Canals, M; Christie, MJ; Geppetti, P; Halls, ML; Hicks, GA; Imlach, WL; Jensen, DD; Klein Herenbrink, C; Lieu, T; McLean, P; Poole, DP; Porter, CJH; Veldhuis, NA; Yarwood, RE | 1 |
| Albu, S; Haney, R; Meagher, MW; You, DS | 1 |
| Aloisi, AM; Bachiocco, V; Bennett, DLH; Bogdanov, YD; Bras, JT; Cox, JJ; Emery, EC; Follenfant, M; Gossage, SJ; Gras, M; Habib, AM; Houlden, H; Humphrey, J; Kolesnikov, A; Komine, Y; Le Cann, K; Li, S; Maniatis, N; Marsili, L; Matsuyama, A; Minett, MS; Okorokov, AL; Panov, KI; Pereira, V; Ponsolles, C; Ramirez, JD; Santana-Varela, S; Sikandar, S; Torres, JM; Wood, JN; Yamamori, T; Yamaoka, K; Zhao, J | 1 |
| Ghaleb, H; Huang, W; Li, H; Li, J; Liao, C; Liu, C; Liu, T; Liu, Y; Qian, H; Wang, N; Zhou, J | 1 |
| De Felice, M; Dodick, DW; Hernandez, PI; Nation, KM; Navratilova, E; Neugebauer, V; Porreca, F | 1 |
| Halldin, MM; Sjögren, E; Stålberg, O; Sundgren-Andersson, AK | 1 |
| González-Ramírez, R; Hiriart, M; Islas, LD; Juárez-Contreras, R; Llorente, I; Morales-Lázaro, SL; Ortíz-Rentería, M; Rosenbaum, T; Sierra-Ramírez, F; Simon, SA | 1 |
| Bjerrum, OJ; Dupont, E; Hellmund, V; Jensen, TS; Jespersgaard, C; Lykkesfeldt, J; Møller, AT; Møller, LB; Nachman, G; Nasser, A; Thorborg, SS | 1 |
| Amagase, K; Kato, S; Matsumoto, K; Tominaga, M; Tsukahara, T; Utsumi, D | 1 |
| Halldin, MM; Jonzon, B; Kullenberg, T; Segerdahl, M; Sjögren, E; Stålberg, O; Sundgren-Andersson, AK | 1 |
| Geisslinger, G; Heinemann, S; Kringel, D; Lötsch, J; Oertel, BG; Resch, E; Thrun, MC | 1 |
| Fields, SA; Linsenbardt, HR; Meagher, MW; Rassu, FS | 1 |
| Blum, R; Brack, A; Kloka, J; Martin, C; Mohammadi, M; Oehler, B; Rittner, HL | 1 |
| Grau, JW; Huang, YJ | 1 |
| Gereau, RW; McIlvried, LA; Mickle, AD; Mohapatra, DP; Shepherd, AJ | 1 |
| Giesler, GJ; Khasabov, SG; Lipshetz, B; Netoff, TI; Simone, DA; Truong, H | 1 |
| Davidova, A; Lesperance, LS; Macpherson, A; Mouchbahani-Constance, S; Petitjean, H; Prescott, SA; Sharif-Naeini, R | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Andrade Próspero, DF; de Castro Almeida, FR; de Sousa, DP; Lopes, EM; Piauilino, CA; Reis Filho, AC | 1 |
| Barik, A; Bharucha-Goebel, D; Bönnemann, CG; Bushnell, MC; Case, L; Chesler, AT; Donkervoort, S; Foley, AR; Ghitani, N; Gordon, T; Lam, R; Liljencrantz, J; Necaise, A; Saade, D; Szczot, M; Thompson, JH | 1 |
| Daou, I; Dubin, AE; Francisco, AG; Keenan, WT; Kühnemund, J; Lewin, GR; Loud, MC; Marshall, KL; Murthy, SE; Patapoutian, A; Schwaller, F | 1 |
| Abdelaziz, R; Barry, AM; Gomez-Varela, D; Jahn, O; Kügler, S; Michel, N; Schmidt, M; Sondermann, JR | 1 |
| Baudouin, C; Ben-Dhaou, C; Melik Parsadaniantz, S; Ouimet, T; Poras, H; Reaux-Le Goazigo, A; Wurm, M | 1 |
| Ruscheweyh, R; Straube, A | 1 |
| Adamante, G; Bellinaso, F; Camponogara, C; Casoti, R; Coelho, YO; da Silva Silveira, E; de Almeida, AS; De Prá, SD; Desideri, AV; Ferreira, J; Milioli, AM; Oliveira, SM; Rigo, FK; Santos, MFC; Trevisan, G | 1 |
| Pang, G; Song, P; Xiao, S; Xie, J; Zhang, Y | 1 |
| Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E | 1 |
| Aghajani, M; Amani, A; Esmaeli, F; Faramarzi, MA; Ghazi-Khansari, M; Ghiasi, Z | 1 |
| Chen, X; Duan, Y; Grant, MB; Obukhov, AG; Riley, AM; Welch, MA; White, FA | 1 |
| Andersen, OK; Frahm, KS; Mørch, CD | 1 |
| Barr, GA; Kuburas, A; Luu, AKS; Marquez de Prado, B; Raj, NR; Recober, A; Rossi, HL | 1 |
| Pintér, E; Szolcsányi, J | 1 |
| Bjerrum, OJ; Dalbøge, LS; Dupont, E; Heegaard, AM; Jensen, TS; Larsen, M; Møller, AT; Møller, LB; Nasser, A | 1 |
| Alemi, F; Bunnett, NW; Cattaruzza, F; Cevikbas, F; Corvera, CU; Cottrell, GS; Geppetti, P; Guerrero-Alba, R; Kwon, E; Lieu, T; Lyo, V; Materazzi, S; Nassini, R; Poole, DP; Schoonjans, K; Steinhoff, M; Valdez-Morales, E; Vanner, SJ | 1 |
| Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A | 1 |
| Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM | 1 |
| Chen, HS; Li, FP; Li, XQ; Lin, Q; Liu, BJ; Qu, F; Wang, Y; Wen, WW | 1 |
| Jürgens, TP; May, A; Reetz, R | 1 |
| Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE | 1 |
| Bhattacharyya, MH; Bollag, WB; Clark, SP; Falls, G; Isales, CM; Johnson, M; Ma, F; Westlund, KN; Xie, D | 1 |
| Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM | 1 |
| Dahl, JB; Petersen, KL; Rowbotham, MC; Werner, MU | 1 |
| Bair, E; Belfer, I; Campbell, CM; Dai, F; Diatchenko, L; Edwards, RR; Lariviere, WR; Liu, Q; Maixner, W; Mogil, JS; Rashid, NU; Segall, SK; Slade, GD; Smith, SB | 1 |
| An, JM; Hong, S; Jin, HJ; Moon, SJ; Park, J | 1 |
| Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA | 1 |
| Katz, NP; Mou, J; Paillard, F; Stoker, M; Trudeau, J; Turnbull, B | 1 |
| Khasabov, SG; Simone, DA | 1 |
| Dolan, S; Goldie, M | 1 |
| Elbaz, AA; Essawy, SS | 1 |
| Knolle, E; Kovacs, GG; Medwed, S; Scharbert, G; Schemper, M; Zadrazil, M | 1 |
| Büchel, C; Geuter, S | 1 |
| Birchmeier, C; Cheng, L; Guo, Z; Lopes, C; Ma, Q; Wende, H; Xu, Y | 1 |
| Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF | 1 |
| Anand, P; Gibbs, JS; Gin-Sing, W; Huson, L; Iddamalgoda, T; Khengar, RH; Libri, V; Pinato, DJ | 1 |
| Büchel, C; Geuter, S; Schenk, LA; Sprenger, C | 1 |
| Sharma, M; Sharma, SK; Vij, AS | 1 |
| Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JL; Kohli, SK | 1 |
| Wallace, MS; Wong, W | 1 |
| Du, J; Kong, L; Niu, L; Sun, N; Xu, Y; Zhu, J | 1 |
| Eddinger, KA; Marino, MJ; Steinauer, JJ; Terashima, T; Xu, Q; Yaksh, TL | 1 |
| Andreev, YA; Bondarenko, DA; Dyachenko, IA; Grishin, EV; Kabanova, NV; Kolesnikov, SS; Korolkova, YV; Kotova, PD; Kozlov, SA; Murashev, AN; Rogachevskaja, OA; Skobtsov, DI | 1 |
| Almeida, AF; Almeida, EC; Araujo, BS; Cunha, RS; Curvello, RL; Damascena, NP; Dias, AS; Estevam, CS; Lima, AC; Paixão, MS; Quintans Júnior, LJ; Santos, CC; Souza, LM; Souza, MT | 1 |
| Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV | 1 |
| Alexandre-Moreira, MS; Alves, Hda S; Campesatto, EA; Cavalcante-Silva, LH; Chaves, MC; de Queiroz, AC; Dias, Tde L; Melo, GM; Santos, Mda S | 1 |
| Boylan, F; Dias Fernandes, P; Miltojević, AB; Pinheiro, MM; Radulović, NS | 1 |
| Cai, Q; Hu, WP; Liu, TT; Liu, YM; Qiu, CY; Qiu, F; Qu, ZW | 1 |
| Mizoguchi, H; Sakurada, S; Sakurada, T; Sato, T; Takagi, H; Watanabe, C; Yonezawa, A | 1 |
| Barragán-Iglesias, P; Bravo-Hernández, M; Cervantes-Durán, C; Granados-Soto, V; Muñoz-Islas, E; Pineda-Farias, JB; Quiñonez-Bastidas, GN; Vidal-Cantú, GC | 1 |
| Akiyama, T; Carstens, E; Carstens, MI; Nagamine, M | 1 |
| Bhatti, R; Kaur, M; Sharma, S; Singh, A; Singh, P | 1 |
| An, S; Cho, SA; Gao, XH; He, QQ; Kim, S; Lai, W; Lee, E; Lee, J; Li, L; Liang, H; Liu, W; Oh, M; Shin, K; Wang, XM; Yeon, JH | 1 |
| Dickie, AC; Torsney, C | 1 |
| Brown, SH; Hung, LY; Maracle, E; Srbely, JZ | 1 |
| Amiji, MM; Ferris, C; Kulkarni, P; Shah, L | 1 |
| Lacković, Z; Matak, I; Rossetto, O | 1 |
| Doods, H; Gorham, L; Just, S | 1 |
| Forster, C; Handwerker, HO; Hartmann, EM | 1 |
| Dancey, E; Murphy, B; Srbely, J; Yielder, P | 1 |
| Bouffard, J; Bouyer, LJ; Gagné, M; Lamothe, M; Mercier, C; Roy, JS | 1 |
| Creech, SK; Meagher, MW; Smith, JS; Vichaya, EG; You, DS; Young, EE | 1 |
| Brooks, JR; Smith, H | 1 |
| Kwon, YB; Pyun, K; Son, JS | 1 |
| Aicher, SA; Hegarty, DM; Hermes, SM; Largent-Milnes, TM | 1 |
| Bonin, RP; De Koninck, Y | 1 |
| Asaki, T; Brown, K; Engel, J; Hasegawa, T; Iso, Y; Iwamoto, Y; Kanemasa, T; Kato, A; Kurose, N; Kyle, DJ; Ni, C; Patel, A; Shet, M; Shintani, T; Tafesse, L; Tsuno, N; Wu, G; Yamaguchi, Y; Yu, J; Zhou, X | 1 |
| Shah, R | 1 |
| Jakubowska, A; Kulig, K; Sałat, K | 1 |
| Lee, M | 1 |
| Bischoff, JM; Petersen, M; Ringsted, TK; Sommer, C; Uçeyler, N; Werner, MU | 1 |
| Avelino, A; Birder, LA; Coelho, A; Cruz, CD; Cruz, F; Shinde, S; Wolf-Johnston, AS | 1 |
| Brito, JP; Carranza Leon, BG; Griebeler, ML; Montori, VM; Morey-Vargas, OL; Murad, MH; Phung, OJ; Tsapas, A; Wang, Z | 1 |
| Callaghan, BC; Feldman, EL | 1 |
| Harano, N; Hitomi, S; Inenaga, K; Kuramitsu, S; Matoba, M; Matsuo, K; Miyano, K; Ono, K; Ota, Y; Seta, Y; Uezono, Y; Yamaguchi, K | 1 |
| Guindon, J; Lin, JS | 1 |
| Børglum, AD; Demontis, D; Finnerup, NB; Horjales-Araujo, E; Schaldemose, EL; Svensson, P | 1 |
| Cianchetti, C; Luvisetto, S; Vacca, V | 1 |
| Moeller-Bertram, T; Silberberg, A; Wallace, MS | 1 |
| Buschow, R; Hucho, T; Isensee, J; Kuss, AW; Weissmann, R; Wenzel, C | 1 |
| Akopian, AN; Bierbower, SM; Dong, X; Geng, Y; Guan, Y; Jeske, NA; Mo, GC; Patel, KN; Tang, Z; Tiwari, V; Wang, Y; Weng, HJ; Zhang, J; Zheng, Q; Zou, W | 1 |
| Fazzari, J; Lin, H; Murphy, C; Singh, G; Ungard, R | 1 |
| Andersen, HH; Arendt-Nielsen, L; Gazerani, P; Nikbakht, A; Poulsen, JN; Uchida, Y | 1 |
| Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K | 1 |
| Chen, X; Claggett, B; Egorova, N; Freeman, S; Gollub, RL; Kaptchuk, TJ; Kirsch, I; Kong, J; Yu, R | 1 |
| Dahan, A; Niesters, M; Olofsen, E | 1 |
| Cai, J; Kong, JG; Liao, FF; Liu, FY; Wan, Y; Xiao, X; Xing, GG; Xu, LC; Yi, M; Yue, LP; Zhao, XT | 1 |
| Furue, H; Takayama, Y; Tominaga, M; Uta, D | 1 |
| Curt, A; Jutzeler, CR; Kramer, JL | 1 |
| Bao, L; Dong, F; Ma, XL; Zhang, FX; Zhang, X | 1 |
| Bogdanov, Y; Crow, M; Denk, F; Grant, AD; Kelleher, JH; Khovanov, N; McMahon, SB; Sharma, S; Wood, JN | 1 |
| Greffrath, W; Henrich, F; Klein, T; Magerl, W; Treede, RD | 1 |
| Evangelista, S | 1 |
| Benschop, RJ; Collins, EC; de Hoon, J; Grayzel, D; Monteith, D; Van Hecken, A; Vermeersch, S; Wroblewski, VJ | 1 |
| Praud, V | 1 |
| Gomes, KS; Mascarenhas, DC; Nunes-de-Souza, RL | 1 |
| Balboni, G; Byun, JS; Congiu, C; De Petrocellis, L; Deplano, A; Di Marzo, V; Garrido, M; Lee, JY; Messeguer, A; Onnis, V; Schiano Moriello, A; Sohn, JM; Vázquez-Romero, A; Zamponi, GW; Zhang, FX | 1 |
| Calixto, JB; de Andrade, EL; Dutra, RC; Nguelefack, TB; Paszcuk, AF | 1 |
| Sandkühler, J | 1 |
| Groneberg, AH; Klein, T; Mouraux, A; Pfau, DB; Treede, RD; van den Broeke, EN | 1 |
| Huang, W; Pan, M; Qian, H; Qiu, Q; Wang, J; Yan, L | 1 |
| Dong, X; Duan, J; Guan, Y; He, Q; Jian, T; Lan, L; Liu, Q; Shi, H; Tang, M; Tang, Z; Wang, C; Wang, Z; Wu, G; Yang, N; Yang, Y; Yu, G; Zhu, C | 1 |
| Broadhurst, KA; Kothari, SD; Lara, O; Luu, ASK; Mohapatra, DP; Recober, A; Rossi, HL | 1 |
| Cohen, E; Lee, YC | 1 |
| Eisenach, JC; Hayashida, K; Kimura, M; Suto, T | 1 |
| Jiang, Y; Lai, R; Lv, HN; Sun, XY; Wang, K; Wei, NN; Wu, Y; Yang, SL | 1 |
| Baron, R; Binder, A; Hüllemann, P; Nerdal, A; Shao, YQ; Watfeh, R | 1 |
| Andreev, YA; Dyachenko, IA; Grishin, EV; Logashina, YA; Murashev, AN | 1 |
| Konno, H; Matoba, M; Miyano, K; Murakami, S; Nishimura, H; Shiraishi, S; Sudo, Y; Uezono, Y | 1 |
| Artola, A; Bourgois, N; Dallel, R; Peirs, C | 1 |
| Fu, M; Huang, W; Pan, M; Qian, H; Wang, J; Yan, L | 1 |
| Buck, B; Grönniger, E; Holtzmann, U; Jung, KA; Neufang, G; Rippke, F; Schoelermann, AM; Stäb, F; Sulzberger, M; Wenck, H; Worthmann, AC | 1 |
| Buck, B; Conzelmann, S; Grönniger, E; Jung, KA; Schoelermann, AM | 1 |
| Duan, R; Liu, W; Locke, C; Nothaft, W; Wallace, M | 1 |
| Burns, LE; Emrick, JJ; Gibbs, JL; Janal, MN; Ramsey, AA | 1 |
| Huang, Y; Li, J; Ma, C; Shen, L; Wang, T; Xu, Y; Yuan, T; Zhang, W; Zhu, J | 1 |
| Gan, X; Hu, WP; Li, YK; Qiu, CY; Ren, C; Wu, J | 1 |
| Abaei, M; Auer, DP; Chapman, V; Prior, M; Sagar, DR; Spicer, CH; Stockley, EG | 1 |
| Fang, Y; Fu, Q; Liu, C; Shen, D; Zhang, F; Zhang, J | 1 |
| Dickenson, AH; Iannetti, GD; Lee, MC; Liang, M; O'Neill, J | 1 |
| Chen, M; Gegen, T; Guo, CJ; He, Q; Hu, D; Li, F; Liu, Q; Shi, H; Tang, M; Tang, Z; Wang, C; Wang, Z; Yang, N; Yang, Y; Yu, G; Zhu, C | 1 |
| Anand, P; Anand, U; Fox, M; Hein, P; Korchev, YE; McQuillan, A; Mukerji, G; Quick, T; Sinisi, M; Yiangou, Y | 1 |
| Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA | 1 |
| Buitenweg, JR; Doll, RJ; Groeneveld, GJ; Hay, JL; van Amerongen, G; Veltink, PH | 1 |
| Endo, Y; Nemoto, W; Shima, K; Sugawara, S; Takano-Yamamoto, T; Tan-No, K; Tsuchiya, M | 1 |
| Arendt-Nielsen, L; Harris, S; Hummel, M; Kapil, R; Knappenberger, T; Kyle, D; O'Keefe, S; Whiteside, GT | 1 |
| Bradshaw, H; Carey, LM; Cornett, B; Hohmann, AG; Leishman, E; Mackie, K; Slivicki, RA | 1 |
| Itomi, Y; Kawamura, T; Tsukimi, Y | 1 |
| Amorim, RM; Assreuy, AM; Cajazeiras, JB; Cavada, BS; do Nascimento, KS; Dos Santos-Nascimento, T; Leal-Cardoso, JH; Mota, MR; Pires, AF | 1 |
| Borbély, É; Helyes, Z; Kemény, Á; Markovics, A; McDougall, JJ; Pintér, E; Quinn, JP; Sándor, K; Szolcsányi, J | 1 |
| Baron, R; Binder, A; Dierschke, R; Förster, M; Großkopf, M; Helfert, S; Hüllemann, P; Keller, T | 1 |
| Black, E; Forbes, M; Kisely, S; Lalloo, R; Sawyer, E | 1 |
| Asad, AB; Baumgartner, R; Chin, CL; Derbyshire, SW; Evelhoch, JL; Feng, D; Henry, B; Houghton, A; Jensen, A; Manigbas, E; Seah, S | 1 |
| Frias, B; Merighi, A | 1 |
| Bartus, É; Hetényi, A; Jósvay, K; Martinek, TA; Németh, L; Oláh, Z; Szakonyi, G; Wéber, E; Winter, Z | 1 |
| Babes, A; Becker, C; Engel, MA; Khalil, M; Kistner, K; Neurath, MF; Reeh, PW; Selescu, T; Siklosi, N; Wirtz, S; Zimmermann, K | 1 |
| Fattori, V; Hohmann, MS; Pinho-Ribeiro, FA; Rossaneis, AC; Verri, WA | 1 |
| Amris, K; Atzeni, F; Branco, J; Choy, E; Dean, LE; Dincer, F; Fluß, E; Häuser, W; Jones, GT; Kosek, E; Kronisch, C; Leino-Arjas, P; Longley, K; Macfarlane, GJ; Makri, S; McCarthy, GM; Perrot, S; Sarzi-Puttini, P; Taylor, A | 1 |
| Bennett, GJ; Bley, K; Coderre, TJ; Gandhi, W; Laferrière, A; Ragavendran, JV; Schweinhardt, P; Ware, MA | 1 |
| Basith, S; Choi, S; Cui, M; Hong, S | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z | 1 |
| Finn, DP; Lenihan, R; Madasu, MK; Okine, BN; Olango, WM; Rea, K; Roche, M | 1 |
| Aboushousha, R; Altier, C; Basso, L; Flynn, R; Iftinca, M; Melo, H; Taylor, L | 1 |
| Goda, Y; Hakamatsuka, T; Hanawa, T; Hyuga, M; Hyuga, S; Jinno, H; Kobayashi, Y; Nakamori, S; Odaguchi, H; Takahashi, J; Tanaka-Kagawa, T | 1 |
| Islas, LD; Llorente, I; López-Romero, AE; Morales-Lázaro, SL; Ortíz-Rentería, M; Rosenbaum, T; Serrano-Flores, B; Sierra-Ramírez, F; Simon, SA | 1 |
| Berta, T; Bey, AL; Chang, W; Han, Q; Ji, RR; Jiang, YH; Kim, YH; Lay, M; Liu, D; Wang, X; Zhang, Y; Zhang, ZJ | 1 |
| Didangelos, A; McMahon, SB; O'Reilly, BA; Offiah, I | 1 |
| Jørgensen, MR; Pedersen, AM | 1 |
| Fujita, T; Kumamoto, E; Piao, LH; Yu, T | 1 |
| Fischer, MJM; Namer, B; Reeh, PW; Schwarz, MG | 1 |
| Borta, A; Brand, T; Nicolas, LB; Reitmeir, P; Roebling, R; Schaffler, K; Scholpp, J | 1 |
| Déciga-Campos, M; Flores-Guido, JS; Ortiz-Andrade, R; Ramírez Camacho, MA; Sanchez-Recillas, A | 1 |
| Balg, F; Goffaux, P; Harvey, MP; Houde, F; Léonard, G; Martel, M | 1 |
| Amuzescu, B; Caruntu, C; Deftu, A; Filippi, A; Gheorghe, RO; Ristoiu, V | 1 |
| Carbone, E | 1 |
| Baeyens, JM; Cervero, F; Cobos, EJ; Coderre, TJ; Gonzalez-Cano, R; Lehmann, M; Pitcher, MH; Vincent, K | 1 |
| Bonacorso, HG; Brum, ES; Brusco, I; Frizzo, CP; Oliveira, SM; Rodrigues, MB; Rosa, WC; Zanatta, N | 1 |
| Bagoly, T; Bölcskei, K; Botz, B; Füredi, R; Pethő, G; Pintér, E; Szolcsányi, J | 1 |
| Balan, AC; Caous, CA; Couture, R; Koepp, J; Lindsey, CJ | 1 |
| Chen, Y; Han, JS; Li, GX; Li, T; Liu, FY; Luo, H; Shi, YS; Wan, Y; Xing, GG; Xu, IS; Yang, F; Yu, L | 1 |
| Wang, Y | 1 |
| Favorov, OV; Li, Y; Quibrera, M; Tommerdahl, M; Whitsel, BL | 1 |
| Brown, S; Simpson, DM; Tobias, J | 1 |
| Chancellor, MB; Chiang, PH; Chuang, YC; Huang, CC; Wu, M; Yoshimura, N | 1 |
| Carr, R; Handwerker, HO; Johanek, LM; Namer, B; Ringkamp, M; Schmelz, M | 1 |
| de Souza, MM; Filho, AW; Filho, VC; Olinger, L | 1 |
| Andreev, YA; Grishin, EV; Ivanova, EA; Koshelev, SG; Kozlov, SA; Kozlovskaya, EP; Monastyrnaya, MM | 1 |
| Dafre, AL; Farina, M; Jacques, AV; Mendes, BG; Meotti, FC; Nascimento, FP; Pizzolatti, MG; Ribas, CM; Rodrigues, AL; Santos, AR; Soldi, C | 1 |
| Bai, ZT; Cheng, M; Ji, YH; Jiang, F; Liu, T; Pang, XY | 1 |
| Hasegawa, M; Honda, K; Iwata, K; Kanda, K; Kitagawa, J; Kondo, M; Noma, N; Okamoto, R; Saito, K; Suzuki, I; Tsuboi, Y | 1 |
| Derry, S; McQuay, HJ; Moore, RA | 1 |
| Gonlachanvit, S; Kullavanijaya, P; Mahayosnond, A | 1 |
| Engel, S; Lee, BB; McLachlan, E; Wasner, G | 1 |
| Jesse, CR; Nogueira, CW; Savegnago, L | 1 |
| Eijkelkamp, N; Elsenbruch, S; Heijnen, CJ; Holtmann, G; Kavelaars, A; Schedlowski, M | 2 |
| Fang, L; Li, D; Lin, Q; Ren, Y; Xu, X; Zou, X | 1 |
| Callsen, MG; Finnerup, NB; Jensen, TS; Moller, AT; Sorensen, K | 1 |
| Meisner, JG; Reid, AR; Sawynok, J | 1 |
| LaMotte, RH; Shimada, SG | 1 |
| Asanuma, T; Inanami, O; Kuwabara, M; Sato, M; Yasui, H | 1 |
| Fukushima, O; Kawabata, A; Matsunami, M; Mitani, K; Nagasawa, K; Okubo, K; Takemura, M; Tarui, T; Yoshida, S | 1 |
| Bean, BP; Binshtok, AM; Gerner, P; Hevelone, ND; Wang, CF; Wang, GK; Woolf, CJ | 1 |
| Hingtgen, CM | 1 |
| de Groat, WC; Glorioso, JC; Goss, J; Sculptoreanu, A; Srinivasan, R; Watkins, S; Wolfe, D | 1 |
| Backonja, M; Blonsky, ER; Cutler, BJ; Malan, P; Rauck, R; Tobias, J; Wallace, MS | 1 |
| De Felice, M; Fioravanti, B; Gardell, LR; Ibrahim, M; King, T; Lai, J; Luo, MC; Malan, TP; Medler, KA; Ossipov, MH; Porreca, F; Stucky, CL; Vanderah, TW; Yamamura, HI | 1 |
| Lee, MC; Menon, DK; Tracey, I; Zambreanu, L | 1 |
| Honda, K; Iwata, K; Kitagawa, J; Kondo, M; Sessle, BJ; Tsuboi, Y; Yonehara, Y | 1 |
| Carlton, SM; Du, J; Zhou, S | 1 |
| Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H | 1 |
| Lin, JY; Reilly, S; Roman, C; St Andre, J | 1 |
| Campbell, CM; Campbell, JN; Carmona, C; Carteret, A; Edwards, RR; Frost, J; Kim, YK; Uhart, M; Wand, G | 1 |
| Iwata, K; Kitagawa, J; Tsujimura, T; Ueda, K | 1 |
| García-López, BE; Granados-Soto, V; Herrejon-Abreu, EB; López-Santillán, FJ; Murbartián, J; Rocha-González, HI | 1 |
| Bodnar, I; Kvetnanský, R; Mravec, B; Nagy, GM; Palkovits, M; Tillinger, A | 1 |
| Chung, JM; Chung, K; Kim, HY; Klann, E; Lee, I; Schwartz, ES; Wang, J | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
| Arendt-Nielsen, L; Gibson, W; Graven-Nielsen, T; Sessle, BJ | 1 |
| Mense, S | 1 |
| Gavva, NR; Wong, GY | 1 |
| Elekes, K; Helyes, Z; Sándor, K; Szolcsányi, J | 1 |
| Cui, L; Kim, H; Kim, J; Kim, SJ | 1 |
| Baumgärtner, U; Birklein, F; Gawlitza, M; Geber, C; Jantsch, HH; Krämer, HH; Magerl, W; Treede, RD | 1 |
| Fantegrossi, WE; Galuska, CM; Ko, MC; Prinssen, EP; Wichmann, J; Woods, JH | 1 |
| Andersen, OK; Arendt-Nielsen, L; Hölzl, R; Kleinböhl, D; Stolle, AM; Trojan, J | 1 |
| Brink, TS; Potenzieri, C; Simone, DA | 1 |
| Boeckxstaens, GE; Bulmer, DC; de Jonge, WJ; Lee, K; van den Wijngaard, RM; Welting, O; Wouters, MM | 1 |
| Coffman, KL | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Nieto, FR | 1 |
| Bach, FW; Jensen, TS; Terkelsen, AJ | 1 |
| Gear, RW; Levine, JD; Tambeli, CH | 1 |
| Ardenghi, JV; Bresciani, LF; Cechinel-Filho, V; De Souza, MM; Delle Monache, F; Mora, TC; Pereira, MA; Yunes, RA | 1 |
| Gál, V; Kóbor, I; Vidnyánszky, Z | 1 |
| Buschmann, H; Grosse Maestrup, E; Holenz, J; Schepmann, D; Vela, JM; Wiese, C; Wünsch, B | 1 |
| Barrot, M; Charlet, A; Freund-Mercier, MJ; Poisbeau, P; Yalcin, I | 1 |
| Fan, RJ; Kung, JC; Olausson, BA; Shyu, BC | 1 |
| Green, BG; LaMotte, RH; Shimada, SG; Sikand, P | 1 |
| Bastos, LC; Tonussi, CR | 1 |
| Fehrenbacher, JC; Hargreaves, KM; Henry, MA; Locke, EE; Sun, XX | 1 |
| Cervero, F; Fernandez, C; Price, TJ; Sanoja, R; Tortorici, V | 1 |
| Schmelz, M | 1 |
| Bloom, AP; Delong, D; Freeman, KT; Ghilardi, JR; Jimenez-Andrade, JM; Koewler, NJ; Kuskowski, MA; Mantyh, PW; Mantyh, WG | 1 |
| Babbar, S; Beliveau, M; Bley, K; Chanda, S; Marier, JF; Mouksassi, MS; Vanhove, GF | 1 |
| Iwata, Y; Komatsu, T; Kuwahata, H; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M | 1 |
| Babes, A; Ciobanu, C; Reid, G | 1 |
| Annas, P; Deeprose, C; Edgar, CJ; Kalliomäki, J; Karlsten, R; Philipp, A; Segerdahl, M; Wesnes, KA | 1 |
| Babes, A; Barbu, I; Ciobanu, C; Kerek, F; Neacsu, C; Szegli, G; Toader, O | 1 |
| Andresen, T; Arendt-Nielsen, L; Brock, C; Drewes, AM; Frøkjaer, JB; Gale, J; Olesen, AE | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos-Buzzi, F; Delle Monache, F; Fracasso, M; Niero, R; Padaratz, P | 1 |
| Bagetta, G; Corasaniti, MT; Katsuyama, S; Komatsu, T; Kuwahata, H; Morrone, LA; Sakurada, S; Sakurada, T | 1 |
| Baggio, CH; Freitas, CS; Luiz, AP; Marcon, R; Nascimento, FP; Pizzolatti, MG; Santos, AR; Soldi, C; Werner, MF | 1 |
| Fischer, MJ; Messlinger, K; Sixt, ML | 1 |
| Fan, GC; Jones, WK; Kranias, EG; Liao, S; Lorenz, J; Ren, X; Schultz, JE; Wang, Y; Weintraub, NL; Zhang, JM | 1 |
| Evans, MS; Jeffry, JA; Parihar, A; Premkumar, LS; Sikand, P; Yu, SQ | 1 |
| Chen, CW; Lu, YC; Wang, SY; Wu, FS | 1 |
| Borges, RM | 2 |
| Chun, YH; Ro, JY | 1 |
| Akesson, J; Gustafsson, H; Lau, CL; Miller, L; Rolan, P; Williams, D; Yap, S | 1 |
| Chen, J; Cui, XY; DU, YR; Lv, ZM; Tian, LJ; Xiao, Y; Yu, YQ | 1 |
| Hoon, MA; Mishra, SK | 1 |
| Tanahashi, M; Uchida, W; Yoshioka, K | 1 |
| Ziegler, D | 1 |
| Kondo, S; Matsumoto, M; Ueda, H; Usdin, TB | 1 |
| Hamity, MV; Hammond, DL; White, SR | 1 |
| Chuang, HH; Lin, S | 1 |
| Donaldson, LF; Dunham, JP; Leith, JL; Lumb, BM | 1 |
| Verkman, AS; Zhang, H | 1 |
| Coghill, RC; Papoiu, AD; Patel, T; Wang, H; Wang, N; Yosipovitch, G | 1 |
| Chen, W; Lao, L; Marvizón, JC; Zhang, G | 1 |
| Alexandre-Moreira, MS; Barbosa-Filho, JM; Chaves, MC; da Silva, DJ; de Aquino, AB; de Araújo-Júnior, JX; de Athayde-Filho, PF; de Lira, DP; de Miranda, GE; de Queiroz, AC; de Souza, ET; Lorenzo, VP; Mella, EA; Santos, BV | 1 |
| Evers, AW; Kraaimaat, FW; van Laarhoven, AI; Wilder-Smith, OH | 1 |
| Chahl, LA; Dalton, VS; Newson, P; Wang, H; Zavitsanou, K | 1 |
| Keppel Hesselink, JM; Kopsky, DJ | 1 |
| Campbell, CM; Campbell, JN; Carteret, A; Edwards, RR; Haythornthwaite, JA; Loggia, ML; Simango, M; Witmer, K | 1 |
| Carmichael, NME; Charlton, MP; Dostrovsky, JO | 1 |
| Brighina, F; De Tommaso, M; Fierro, B; Giglia, F; Giglia, G; Palermo, A | 1 |
| Ahn, DK; Bean, BP; Binshtok, AM; Chung, G; Hwang, SJ; Jung, SJ; Kang, Y; Kim, HY; Kim, JS; Kim, K; Lee, MK; Li, HY; Oh, SB; Park, CK; Woolf, CJ | 1 |
| Al Ghamdi, KS; Polgár, E; Todd, AJ | 1 |
| Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Modir, JG; Wallace, MS | 1 |
| Islas, LD; Rosenbaum, T; Simon, SA | 1 |
| de Mello, CF; de Oliveira Ferreira, AP; Ferreira, J; Rossato, MF; Velloso, NA | 1 |
| Arendt-Nielsen, L; Lyngholm, AM; Petersen, LJ | 1 |
| Curry, R; Eisenach, JC; Houle, TT; Tong, C; Yaksh, TL | 1 |
| Barreiro, EJ; Castro, NG; Duarte, CD; Fraga, CA; Guimaraes, MZ; Lima, CK; Maia, RC; Mesquita, CM; Miranda, AL; Santos, ML; Silva, LL; Tributino, JL | 1 |
| Coderre, TJ; Kumar, N; Laferriere, A; Poon, T; Yu, JS | 1 |
| Papoiu, AD; Yosipovitch, G | 1 |
| Buenaver, LF; Campbell, CM; Edwards, RR; Haythornthwaite, JA; Quartana, PJ | 1 |
| Arendt-Nielsen, L; Boudreau, SA; Hennings, K; Sessle, BJ; Svensson, P | 1 |
| Iannetti, GD; Mouraux, A; Plaghki, L | 1 |
| El Mouedden, M; Joosten, L; Kalff, KM; Meert, T; Scheffer, GJ; van Egmond, J; Veening, J; Vissers, K | 1 |
| Brown, S; Gazda, S; Lu, SP; Simpson, DM; Tobias, JK; Vanhove, GF; Webster, LR | 1 |
| Beattie, RE; Knopp, K; Liu, B; Sher, E; Ursu, D | 1 |
| Anderson, IB; Blanc, PD; Hudmon, KS; Kearney, TE; Kim-Katz, SY; MacDougall, C | 1 |
| Al-Khrasani, M; Brendl, U; Fürst, S; Mousa, SA; Schäfer, M; Shaqura, M | 1 |
| Almeida, JR; Araujo, AA; Araújo, DA; Bonjardim, LR; De Sousa, DP; Gelain, DP; Gonçalves, JC; Melo, MS; Onofre, AC; Quintans-Júnior, LJ | 1 |
| Jang, CG; Kim, HC; Lee, SY; Nam, YS; Nguyen, TL | 1 |
| Chen, SL; Dong, X; Fang, JY; Li, Y; Liu, ZL; Mo, JZ; Xiao, SD; Zhang, LY | 1 |
| Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç | 1 |
| Brüning, CA; Nogueira, CW; Prigol, M; Roehrs, JA; Zeni, G | 1 |
| Bai, ZT; Cheng, M; Hua, LM; Ji, YH; Jiang, F; Liu, T; Pang, XY; Shi, J; Shu, XQ; Zhang, JW; Zhou, JJ | 1 |
| Akhtar, MN; Israf, DA; Khalid, MH; Khalid, S; Lajis, NH; Mohamad, AS; Mohd, PA; Perimal, EK; Sulaiman, MR; Zakaria, ZA | 1 |
| Bian, ZX; Luo, JL; Qi, SD; Qin, HY; Sung, JJ; Xu, HX | 1 |
| Fu, Z; Ge, L; Hu, X; Huang, W; Lin, H; Lin, R; Qian, H; Zhang, H; Zhou, J | 1 |
| Antoniolli, AR; Araújo, AA; Bonjardim, LR; Cavalcanti, SC; Gelain, DP; Guimarães, AG; Melo, MS; Moreira, JC; Oliveira, GF; Quintans-Júnior, LJ; Rocha, RF; Santos, JP; Silva, FA | 1 |
| Lam, VY; Schulteis, G; Wallace, M | 1 |
| Akashi, R; Ishikura, H; Kawabata, A; Kitamura, T; Matsumura, K; Matsunami, M; Naruse, M; Nishimura, S; Sekiguchi, F; Shinozaki, Y | 1 |
| Bang, S; Cho, H; Hwang, SW; Kim, KY; Lee, SH; Park, JS; Ryu, JJ; Yang, TJ; Yoo, S | 1 |
| Ferrari, LF; Gear, RW; Levine, JD | 1 |
| D'Arcy, Y | 1 |
| Abdel Samad, O; Duan, B; Ji, RR; Liu, Y; Lopes, C; Lowell, BB; Ma, Q; Tong, Q; Zhang, L | 1 |
| Akiyama, T; Carstens, E; Carstens, MI | 1 |
| Athayde, ML; de Oliveira, AP; Ferreira, J; Gomez, MV; Klafke, JZ; Rossato, MF; Royes, LF; Trevisan, G; Villarinho, JG; Walker, CI; Zanon, RB | 1 |
| Aoki, T; Kakimoto, S; Kiso, T; Kohara, A; Kuramochi, T; Matsuoka, N; Tsuji, N; Watabiki, T; Yonezawa, K | 1 |
| Beime, B; Chrubasik, S; Weiser, T | 1 |
| Chávez, M; González-Trujano, ME; López-Muñoz, FJ; Martínez, AL; Moreno, J; Pellicer, F | 1 |
| Basbaum, AI; Edwards, RH; Harper, B; Hnasko, TS; Low, SA; Scherrer, G; Solorzano, C; Urban, R; Wang, X; Yamanaka, H; Zhang, J | 1 |
| Andresen, T; Arendt-Nielsen, L; Christrup, LL; Drewes, AM; Foster, DJ; Upton, RN | 1 |
| Chen, J; Fu, W; Li, X; Liao, Y; Liu, J; Liu, X; Xu, N; Xu, Z; Yi, W | 1 |
| Drummond, PD; Knudsen, L | 1 |
| Andresen, T; Arendt-Nielsen, L; Drewes, AM; Mansikka, H; Oksche, A; Staahl, C | 1 |
| Appenzeller, M; Bigliardi, P; Buclin, T; Grouzmann, E; Pannatier, A | 1 |
| De Chiaro, M; de Novellis, V; De Petrocellis, L; Di Marzo, V; Guida, F; Maione, S; Moriello, AS; Piscitelli, F | 1 |
| Chen, B; Chu, Y; Jia, X; Liu, Q; Wei, Y; Zhang, J | 1 |
| Büsselberg, D; Hagenacker, T; Ledwig, D | 1 |
| Brighina, F; Cosentino, G; De Tommaso, M; Fierro, B; Giglia, F; Giglia, G; Panetta, M; Puma, A; Scalia, S | 1 |
| Artola, A; Dallel, R; Lapirot, O; Luccarini, P; Melin, C; Messaoudi, Y; Modolo, A; Monconduit, L; Nicolas, C | 1 |
| Buzas, K; Cohen, JI; Fan, H; Howard, OM; Klinman, D; Mont, E; Oppenheim, JJ; Qi, J; Wang, K | 1 |
| Duan, JH; Duarte, DB; Hingtgen, CM; Nicol, GD; Vasko, MR | 1 |
| Baccei, ML; Li, J | 1 |
| Anand, P; Roberts, K; Shenoy, R | 1 |
| de Oliveira, SM; Ferreira, J; Gomez, MV; Hoffmeister, C; Rossato, MF; Trevisan, G | 1 |
| Cao, DY; Guo, Y; Luo, R; Ma, SJ; Pickar, JG; Wang, J; Zhao, Y | 1 |
| Komatsu, T; Mizoguchi, H; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, M; Tsuzuki, M | 1 |
| Lu, B; Murphy, FT; Peppin, JF; Tobias, JK; Vanhove, GF; Webster, LR | 1 |
| Goadsby, PJ; Kavantzas, N; Knight, YE; Lasalandra, M; Mitsikostas, DD | 1 |
| Pandit, S; Ringdahl, E | 1 |
| Kissin, I; Szallasi, A | 1 |
| Iadarola, MJ; Mannes, AJ | 1 |
| Szallasi, A | 1 |
| Katsuyama, S; Komatsu, T; Mizoguchi, H; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M | 1 |
| LeRoy, P | 1 |
| Barabas, ME; Brandow, AM; Hillery, CA; Kerstein, PC; Retherford, D; Stucky, CL; Vilceanu, D; Wandersee, NJ | 1 |
| Bang, S; Cho, H; Hwang, SW; Yang, TJ; Yoo, S | 1 |
| Aykanat, V; Briggs, N; Gentgall, M; Rolan, P; Williams, D; Yap, S | 1 |
| Abooj, M; Bishnoi, M; Bosgraaf, CA; Premkumar, LS; Zhong, L | 1 |
| Brenchat, A; Hamon, M; Romero, L; Vela, JM; Zamanillo, D | 1 |
| Ji, W; Liang, J; Xiao, G | 1 |
| Anand, P; Bley, K | 1 |
| Holstege, JC; Hossaini, M; Jongen, JL; Saraç, C | 1 |
| Carlton, SM; Du, J; Govea, R; Zhou, S | 1 |
| Hitomi, S; Honda, K; Inoue, M; Iwata, K; Katagiri, A; Kiyomoto, M; Matsuura, S; Shiga, Y; Shinoda, M; Tsuji, K; Tsujimura, T | 1 |
| Amet, T; Byrd, D; Chang, KH; Chi, X; Duan, J; Grantham, A; Hu, N; Hu, S; Nicol, G; Shah, K; Tao, F; Yu, Q | 1 |
| Beaudry, H; Dubois, D; Gendron, L | 1 |
| Canetta, SE; Luca, E; Pertot, E; Role, LW; Talmage, DA | 1 |
| Gan, Q; Livergood, RS; Panneton, WM | 1 |
| Daugherty, D; Dykstra, LA; Henry, FE; Miller, LL; Picker, MJ | 1 |
| Alenmyr, L; Greiff, L; Herrmann, A; Högestätt, ED; Zygmunt, PM | 1 |
| Austin, JS; Balaban, CD; Belfer, I; Bittong, RA; Campbell, CM; Campbell, JN; Crawley, JN; Czerminski, J; Edwards, RR; Fillingim, RB; Fortin, A; LaCroix-Fralish, ML; Lariviere, WR; Melmed, K; Mogil, JS; Mokris, JB; Neubert, JK; Ritchie, J; Schorscher-Petcu, A; Smith, SB; Sorge, RE; Sotocinal, SG; Sternberg, WF; Wallace, MR | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Basbaum, AI; Bohlen, CJ; Burlingame, AL; Chesler, AT; Julius, D; King, D; Medzihradszky, KF; Sánchez, EE; Sharif-Naeini, R; Zhou, S | 1 |
| Beitz, AJ; Kang, SY; Lee, JH; Moon, JY; Park, JH; Roh, DH; Song, S; Yoon, SY | 1 |
| Imagawa, T; Ohkita, M; Ohta, T; Saito, S; Takahashi, K; Tominaga, M | 1 |
| Robb-Nicholson, C | 1 |
| Jia, MM; Li, XJ; Li, YS; Liu, M; Tang, HB; Wang, JX | 1 |
| Annas, P; Baxendale, J; Kalliomäki, J; Karlsten, R; Philipp, A; Segerdahl, M | 1 |
| Bhaskar, AK | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Koyama, M; Kubo, A; Mizumura, K; Murase, S; Takagishi, Y; Tamura, R | 1 |
| Helmchen, C; Leyendecker, S; Mohr, C; Petersen, D | 1 |
| Bagetta, G; Mizoguchi, H; Sakurada, S; Watanabe, C | 1 |
| Guindon, J | 1 |
| Kawabata, A; Kirishi, S; Matsunami, M; Okui, T | 1 |
| Gomes, LO; Hara, DB; Rae, GA | 1 |
| Ito, K; Kuwahara, M; Makimura, Y; Tsubone, H | 1 |
| Carvalho, JE; Foglio, MA; Pilli, RA; Rodrigues, MT; Spindola, HM; Vendramini-Costa, DB | 1 |
| Dolan, S; Graham, A; Iannitti, T | 1 |
| McCoy, ES; Taylor-Blake, B; Zylka, MJ | 1 |
| Chen, J; Daanen, JF; Faltynek, CR; Franklin, PH; Ghilardi, JR; Gomtsyan, A; Han, P; Joshi, SK; Kort, ME; Kym, PR; Lewis, L; Mantyh, PW; McDonald, HA; Neelands, TR; Pai, M; Puttfarcken, PS; Reilly, RM; Schmidt, RG; Segreti, JA; Turner, TM; Voight, EA | 1 |
| Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB | 1 |
| Sheta, M; Szallasi, A | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Athayde, ML; Boligon, AA; Ferreira, J; Guerra, GP; Klafke, JZ; Oliveira, SM; Rosa, F; Rossato, MF; Tonello, R; Trevisan, G; Walker, CI; Zanon, RB | 1 |
| Finnerup, NB; Fuglsang-Frederiksen, A; Jensen, TS; Johnsen, B; Madsen, CS | 1 |
| Buchbinder, R; Richards, BL; van der Heijde, DM; Whittle, SL | 1 |
| Blum, W; Pecze, L; Schwaller, B | 1 |
| Brown, DT; Erichsen, HK; Hansen, RR; Mirza, NR; Munro, G | 1 |
| Iadarola, MJ; Kaszas, K; Keller, JM; Kominsky, H; Lebovitz, EE; Maric, D | 1 |
| Andresen, T; Brock, C; Dickenson, AH; Nilsson, M; O'Neill, J; Olesen, AE | 1 |
| DeVilbiss, JL; Luu, AK; Recober, A; Rossi, HL | 1 |
| Lam, V; Schettler, J; Wallace, MS | 1 |
| Cao, Y; Ho, KY; Li, X; Wilder-Smith, CH; Wong, RK | 1 |
| Endo, Y; Kim, S; Kuroishi, T; Okada, S; Seiryu, M; Sugawara, S; Takano-Yamamoto, T | 1 |
| Annas, P; Clarke, C; Huizar, K; Kalliomäki, J; Karlsten, R; Segerdahl, M; Zettergren, A | 1 |
| Houlihan, PR; Kim, MS; Medvedeva, YV; Shutov, LP; Usachev, YM | 1 |
| Chen, S; Huang, XJ; Liu, XM; Wei, LS; Yao, J | 1 |
| Agarwal, A; Gupta, D; Kishore, K; Rastogi, S; Singh, PK; Singh, U | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos, F; de Souza, MM; Nunes, RJ; Yunes, RA | 1 |
| Mitsikostas, DD; Sanchez del Rio, M; Waeber, C | 1 |
| Carstens, E; Gogineni, AG; Iodi Carstens, M; Simons, CT | 1 |
| Allardt, A; Baron, R; Binder, A; Bréchôt, A; Jensen, TS; Schattschneider, J; Wasner, G | 1 |
| Bojinov, V; Cechinel, FV; Corrêa, R; de Souza, MM; Grabchev, I | 1 |
| Itoh, H; Kawabata, A; Kawao, N; Kuroda, R; Shimada, C | 1 |
| Barletta, J; Gear, RW; Green, P; Levine, JD; Luo, L; Schmidt, BL; Tambeli, CH | 1 |
| Bargmann, CI; Barstead, R; Kahn-Kirby, A; Madsen, DM; Maricq, AV; Moulder, G; Peckol, EL; Tobin, DM | 1 |
| Cai, Y; Evensjö, M; Kovács, KJ; Larson, AA; McCarson, KE; Shi, Q; Velázquez, RA | 1 |
| Bhave, G; Brasier, DJ; Gereau, RW; Oxford, GS; Wang, H; Zhu, W | 1 |
| Arendt-Nielsen, L; Svensson, P; Wang, K | 1 |
| Kyrkanides, S; Macher, DJ; Olschowka, JA; Stevens, SY; Tallents, RH | 1 |
| Finch, P; Kulkarni, H; Low, A; Mander, J; Perlman, D; Playford, D; Thomas, M; Vivian, J | 1 |
| Anderson, WS; Bencherif, B; Campbell, JN; Frost, JJ; Sheth, RN | 1 |
| Growcott, J; Hughes, A; Macleod, A; Thomas, I | 1 |
| Colley, S; Davis, C; Kotsonis, P; McIntyre, P; Phillips, E; Ranasinghe, S; Rang, H; Savidge, J; Shah, K; Winter, J | 1 |
| Barger, D; Schulteis, G; Wallace, MS | 1 |
| Cervero, F; Laird, JM; Souslova, V; Wood, JN | 1 |
| Curry, R; Eisenach, JC; Hood, DD | 4 |
| Ishida, Y; Nishigaki, M; Shibata, Y; Shimada, S; Ueda, T; Ugawa, S | 1 |
| Ahluwalia, J; Nagy, I; Rang, H | 1 |
| Bencherif, B; Campbell, JN; Dannals, RF; Frost, JJ; Fuchs, PN; Sheth, R | 1 |
| Malisza, KL; Stroman, PW | 1 |
| Ishida, Y; Murakami, S; Shimada, S; Ueda, T; Ugawa, S | 1 |
| Lin, Q; Willis, WD; Zou, X | 3 |
| Erguven, HG; Inaloz, HS; Inaloz, SS; Karakok, M; Kirtak, N | 1 |
| Ahmad, M; Goucke, CR | 1 |
| Calixto, JB; Ferreira, J; Santos, AR; Trentin, AP; Yunes, RA | 1 |
| Andersen, OK; Arendt-Nielsen, L; Drewes, AM; Sumikura, H | 1 |
| McDougall, JJ | 1 |
| Coppini, DV; Potter, J; Spruce, MC | 1 |
| Bron, R; Klesse, LJ; Parada, LF; Shah, K; Winter, J | 1 |
| Ghanem, AN | 2 |
| Bakoshi, S; Inoue, M; Kawashima, T; Kondo, S; Rashid, MH; Ueda, H | 1 |
| Calo, G; Inoue, A; Inoue, M; Kawashima, T; Nakata, Y; Takeshima, H; Ueda, H | 1 |
| Handwerker, HO; Hilliges, M; Schmelz, M; Schmidt, R; Torebjork, HE; Weidner, C | 1 |
| Jung, EA; Nogueira, CW; Quinhones, EB; Rocha, JB; Zeni, G | 1 |
| Allen, RG; Inoue, M; Kawashima, T; Ueda, H | 1 |
| Beirith, A; Calixto, JB; Santos, AR | 1 |
| Casey, KL; Lorenz, J; Minoshima, S | 1 |
| Li, GD; Zhao, ZQ; Zhou, Y | 1 |
| Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K | 1 |
| Bakoshi, S; Inoue, M; Rashid, MH; Ueda, H | 1 |
| Fushiki, T; Hashizume, S; Iida, T; Kobata, K; Morita, A; Moriyama, T; Murayama, N; Tominaga, M; Watanabe, T; Yazawa, S | 1 |
| Bach, FW; Gottrup, H; Jensen, TS; Kristensen, AD | 1 |
| Matsumura, T; Moriyama, T; Sakurada, C; Sakurada, S; Sakurada, T; Ueno, S | 1 |
| Atweh, SF; Bach, JF; Dardenne, M; Jabbur, SJ; Saadé, NE; Safieth-Garabedian, B | 1 |
| Han, JS; Luo, H; Wan, Y | 1 |
| Lee, DC; Ryan, JR | 1 |
| Kobayashi, Y | 1 |
| Mohapatra, DP; Nau, C; Wang, GK; Wang, SY | 1 |
| Bowles, WR; Hargreaves, KM; Jackson, DL | 1 |
| Ball, JW; Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Cheong, JY; Lee, SJ; Yoon, TS | 1 |
| Arendt-Nielsen, L; Dimcevski, G; Drewes, AM; Funch-Jensen, P; Gregersen, H; Petersen, P; Schipper, KP | 1 |
| Foniok, T; Gregorash, L; Malisza, KL; Stroman, PW; Turner, A; Wright, A | 1 |
| Jarvis, MF | 1 |
| Carlton, SM; Coggeshall, RE; Kraemer, B; Zhou, S | 1 |
| Anand, P | 1 |
| Goldin, E; Israelit, Y; Keret, D; Lysy, J; Mindrul, V; Shmueli, A; Sistiery-Ittah, M; Strauss-Liviatan, N | 1 |
| Choi, SS; Han, EJ; Han, KJ; Lee, HK; Suh, HW | 1 |
| Arendt-Nielsen, L; De Armas, L; Fiaschi, A; Le Pera, D; Maiese, T; Restuccia, D; Rosso, T; Tinazzi, M; Tonali, P; Valeriani, M | 1 |
| Jang, JH; Kim, BM; Oh, U; Shin, CY; Shin, J; Surh, YJ; Wang, MH | 1 |
| Auff, E; Eichler, HG; Gustorff, B; Lehr, S; Schmetterer, L; Schnider, P; Sycha, T; Voller, B | 1 |
| Fang, L; Lin, Q; Willis, WD; Wu, J | 1 |
| Bolin, DJ | 1 |
| McCleane, G | 2 |
| Fang, L; Lin, Q; Willis, WD; Wu, J; Zhang, X | 2 |
| Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; Palhares de Miranda, AL; Viegas, C | 1 |
| Farthing, JN; Hohmann, AG; Makriyannis, A; Zvonok, AM | 1 |
| Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC | 1 |
| Choi, J; Joo, YH; Kang, SW; Kim, HD; Kim, JK; Kim, SY; Koo, JY; Lee, J; Lee, YS; Min, KH; Oh, UT; Park, HG; Park, OH; Park, YH; Seung, HS; Suh, YG | 1 |
| Gear, RW; Levine, JD; Quang, P; Tambeli, CH | 1 |
| Fang, L; Willis, WD; Wu, J; Zhang, X | 2 |
| Arendt-Nielsen, L; Chang, PF; Chen, AC; Graven-Nielsen, T; Svensson, P | 3 |
| Dell, H | 1 |
| Fang, L; Lin, Q; Ren, Y; Wang, J; Willis, WD; Zou, X | 1 |
| Gordon, SE; Gordon-Shaag, A; Munari, M; Rosenbaum, T | 1 |
| Bell, TJ; Castiglioni, AJ; Helton, TD; Lipscombe, D; Thaler, C | 1 |
| Dussor, GO; Flores, CM; Hargreaves, KM; Helesic, G | 1 |
| Arai, N; Inoue, K; Mochio, S; N Saito, D; Ohnishi, T; Okabe, S; Tamura, Y; Ugawa, Y | 1 |
| Akerman, S; Goadsby, PJ; Kaube, H | 1 |
| Bach, FW; Fuglsang-Frederiksen, A; Jensen, TS; Kasch, H; Qerama, E | 2 |
| Baumann, TK; Chaudhary, P; Martenson, ME | 1 |
| Bushnell, CM; Feine, JS; Frot, M | 1 |
| Derry, S; Edwards, JE; Mason, L; McQuay, HJ; Moore, RA | 1 |
| Ikeda, H; Kamanaka, Y; Kataoka, K; Kawabata, A; Kawao, N; Kitano, T; Kuroda, R; Sekiguchi, F | 1 |
| Bach, FW; Gottrup, H; Jensen, TS | 1 |
| Tramèr, MR | 1 |
| Baron, R; Binder, A; Jensen, TS; Schattschneider, J; Schwarz, K; Wasner, G | 1 |
| Cortright, DN; Szallasi, A | 1 |
| Magerl, W; Treede, RD | 1 |
| Almási, R; Bölcskei, K; Czéh, G; Hajos, G; Petho, G; Riedl, Z; Sándor, Z; Szolcsányi, J; Varga, A | 1 |
| Cervero, F; Delpire, EJ; García-Nicas, E; Laird, JM | 1 |
| Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Izydorczyk, I; Pethö, G; Reeh, PW | 1 |
| Sun, RQ; Tu, Y; Willis, WD | 1 |
| Johansson, H; Kalezic, I; Kostyukov, AI; Maisky, VA; Pilyavskii, AI; Windhorst, U | 1 |
| Forster, C; Handwerker, HO; Maihöfner, C; Neundörfer, B; Schmelz, M | 1 |
| Drummond, PD | 1 |
| Hammer, HF; Hammer, J; Holzer, P; Schmidt, B | 1 |
| Carlton, SM; Castañeda-Hernandez, G; Du, J; Grady, JJ; Jimenez-Andrade, JM; Yamani, A; Zhou, S | 1 |
| Ito, M; Matsumoto, S; Nasu, M; Takeda, M; Tanimoto, T | 1 |
| Arendt-Nielsen, L; De Armas, L; Le Pera, D; Maiese, T; Restuccia, D; Tinazzi, M; Tonali, P; Valeriani, M | 1 |
| Lumb, BM; McMullan, S; Simpson, DA | 1 |
| Antal, A; Barthó, L; Benkó, R; Holzer, P; Holzer-Petsche, U; Horváth, OP; Illényi, L; Lázár, Z; Patacchini, R; Pethö, G; Undi, S | 1 |
| Higashi, T; Iida, T; Moriyama, T; Murayama, N; Numazaki, M; Togashi, K; Tominaga, M; Tominaga, T | 1 |
| Burette, A; Hwang, SJ; Rustioni, A; Valtschanoff, JG | 1 |
| Jones, CK; Peters, SC; Shannon, HE | 1 |
| Bley, KR | 1 |
| Bernardi, G; Marinelli, S; Mercuri, NB; Pascucci, T; Puglisi-Allegra, S | 1 |
| Beswick, PJ; Bingham, S; Bountra, C; Brown, T; Campbell, IB; Chessell, IP; Clayton, N; Collins, SD; Davey, PT; Goodland, H; Gray, N; Haslam, C; Hatcher, JP; Hunter, AJ; Lucas, F; Murkitt, G; Naylor, A; Pickup, E; Sargent, B; Stevens, A; Stratton, SC; Summerfield, SG; Wiseman, J | 1 |
| Cadiou, H; Jones, NG; McMahon, SB; McNaughton, P; Slater, R | 1 |
| Avelino, A; Bevan, S; Charrua, A; Cruz, F; Dinis, P; Nagy, I; Yaqoob, M | 1 |
| Dahl, JB; Dirks, J; Duedahl, TH; Larsen, NE; Petersen, KB; Romsing, J | 1 |
| Ko, S; Qiu, CS; Toyoda, H; Zhao, MG; Zhuo, M | 1 |
| Coderre, TJ; Soliman, AC; Yu, JS | 1 |
| Maznychenko, AV | 1 |
| Araldi, D; Goncales, CE; Nogueira, CW; Panatieri, RB; Rocha, JB; Zeni, G | 1 |
| Casey, KL; Lorenz, J | 1 |
| Donnerer, J; Liebmann, I; Lippe, IT; Schicho, R | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Chancellor, MB; Chiang, PH; Chuang, YC; DeMiguel, F; Kang, HY; Ma, WL; Wu, PC; Yang, LC; Yoshimura, N | 1 |
| El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ | 1 |
| Bach-Rojecky, L; Lacković, Z | 1 |
| André, E; Calixto, JB; Ferreira, J; Kassuya, CA | 1 |
| Affeltranger, MA; Balaban, CD; McBurney, DH | 1 |
| Cervero, F; Galan, A | 1 |
| Kellogg-Spadt, S; Oyama, IA; Rejba, AE; Steinberg, AC; Whitmore, KE | 1 |
| Deerinck, T; Khan, IM; Polston, K; Singletary, E; Taylor, P; Wennerholm, M; Yaksh, TL; Zhang, L | 1 |
| Angers, P; Dalbó, S; Jürgensen, S; Ribeiro-do-Valle, RM; Santos, AR | 1 |
| Ahern, GP; Brooks, IM; Miyares, RL; Wang, XB | 1 |
| Fang, L; Lei, Y; Willis, WD; Wu, J; Zhang, X | 2 |
| Caudle, RM; Cooper, BY; Johnson, RD; Rau, KK | 1 |
| Elekes, K; Helyes, Z; McDougall, JJ; Németh, J; Pintér, E; Szabó, A; Szolcsányi, J; Varga, A; Zhang, C | 1 |
| Almeida, FR; Campos, AR; Cavalcante, IJ; Chaves, MH; Costa, CL; Lima, AF; Lima, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM | 1 |
| Dolan, RJ; Driver, J; Kalisch, R; Koltzenburg, M; Seymour, B; Stephan, KE; Wiech, K | 1 |
| Jeferson, FA; Rao, VS; Santos, CC; Santos, FA; Silveira, ER | 1 |
| Baad-Hansen, L; Jensen, HM; Poulsen, HF; Svensson, P | 1 |
| Eggenreich, U; Gschanes, A; Reitmeir, P; Schaffler, K | 1 |
| Ando, R; Watanabe, C | 1 |
| Borrelli, E; Erbs, E; Mansikka, H; Pertovaara, A | 1 |
| Fujiuchi, A; Hara, T; Imai, A; Kanai, Y; Nakazato, E | 1 |
| Komatsu, T; Moriyama, T; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M | 1 |
| Gupta, J; Hayashi, F; Hayashi, M; Iino, T; Nakae, K; Yamamoto, N; Yoshikawa, S | 1 |
| Asai, H; Nagamine, K; Ozaki, N; Shinoda, M; Sugiura, Y; Tohnai, I; Ueda, M | 1 |
| Dworkin, RH; Foster, DC; Wood, RW | 1 |
| Abdel-Salam, OM | 1 |
| Flores, CM; Hargreaves, KM; Jeske, NA; Price, TJ | 1 |
| Calixto, JB; Ferreira, J; Medeiros, R; Trichês, KM | 1 |
| Dolan, R; Frackowiak, R; Friston, K; Koltzenburg, M; O'Doherty, JP; Seymour, B; Wiech, K | 1 |
| Carlton, SM; Castañeda-Hernandez, G; Jimenez-Andrade, JM; Valencia de Ita, S; Yamani, A; Zhou, S | 1 |
| Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G | 1 |
| Joshi, PG; Lakshmi, S | 1 |
| Jones, TL; Sorkin, LS | 1 |
| Fang, L; Lei, Y; Li, J; Lin, Q; Ma, L; Su, G; Wu, J; Zhang, X | 1 |
| Dussor, GO; Edell, TA; Flores, CM; Hulsebosch, CE; Jones, DJ | 1 |
| Andersen, OK; Arendt-Nielsen, L; Gazerani, P | 2 |
| Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A | 1 |
| Baamonde, A; Hidalgo, A; Juarez, L; Lastra, A; Menéndez, L | 1 |
| Chen, CH; Liu, JH; Lung, FD | 1 |
| Fujimura, T; Hayashi, T; Katsuyama, S; Mizoguchi, H; Nakayama, D; Sakurada, S; Sakurada, T; Sakurada, W; Sawai, T; Watanabe, C; Watanabe, H; Yuhki, M | 1 |
| Baamonde, A; García, E; García-Suárez, O; Hidalgo, A; Juárez, L; Menéndez, L | 1 |
| Balaban, CD; Frot, M; Lariviere, WR; McBurney, DH | 1 |
| Halkjaer, L; McMillan, AS; Melsen, B; Svensson, P | 1 |
| Andersen, OK; Arendt-Nielsen, L; Pud, D; Yarnitsky, D | 1 |
| Buchanan, TJ; Huggins, JP; Iannetti, GD; Smart, TS; Tracey, I; Vennart, W; Wise, RG; Zambreanu, L | 1 |
| Andersen, OK; Arendt-Nielsen, L; Miyazawa, A; Sumikura, H; Yucel, A | 1 |
| Bunnett, NW; Divino, LA; Grady, EF; Grahn, SW; Hoge, SG; Kim, E; Kirkwood, KS; Wick, EC | 1 |
| Facundo, VA; Marques, MC; Pietrovski, EF; Rios, K; Rosa, KA; Santos, AR | 1 |
| Meisner, J; Reid, A; Sawynok, J | 1 |
| Fujita, T; Jin, YH; Nishioka, H; Wakabayashi, K; Yonehara, N | 1 |
| Manley, GT; Oshio, K; Verkman, AS; Watanabe, H; Yan, D | 1 |
| Buhaĭchenko, LA; Kostiukov, OI; Piliavs'kyĭ, OI | 1 |
| Baad-Hansen, L; Jensen, TS; Kaube, H; List, T; Svensson, P | 1 |
| Argoff, CE | 1 |
| Jensen, MT; Petersen, KL | 1 |
| Borges, VC; Jesse, CR; Moro, AV; Nogueira, CW; Rocha, JB; Santos, FW; Savegnago, L | 1 |
| Carlton, SM; Ji, GC; Jurczyk, S; Reubi, JC; Shapiro, G; Zhou, ST | 1 |
| Arendt-Nielsen, L; Drewes, AM; Gazerani, P; Staahl, C | 1 |
| Hald, A; Inoue, M; Matsumoto, M; Ueda, H; Yamaguchi, A | 1 |
| Hide, I; Inoue, A; Iwasa, M; Nakata, Y; Tang, HB | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JM | 1 |
| Beyer, CE; Brandt, MR; Smith, VA | 1 |
| Balonov, K; Khodorova, A; Strichartz, GR | 1 |
| Bach, FW; Feldt-Rasmussen, U; Hasholt, L; Jensen, TS; Kølvraa, S; Moller, AT; Rasmussen, AK; Sommer, C | 1 |
| Colucci, M; De Felice, M; Giannini, E; Lattanzi, R; Margheriti, F; Melchiorri, P; Negri, L; Porreca, F; Tian, H; Vellani, V | 1 |
| Beitz, AJ; Cho, KH; Choi, SM; Han, HJ; Kang, SY; Kim, HW; Kwon, YB; Lee, HJ; Lee, JH; Roh, DH; Ryu, YH; Yoon, SY | 1 |
| Aoki, KR; Francis, J; Jost, WH | 1 |
| Chapman, V; Marsden, CA; Morris, PG; Moylan Governo, RJ; Prior, MJ | 1 |
| Imamura, Y; Iwata, K; Meng, ID; Ogawa, A; Ren, K | 1 |
| Campos, AR; David, JM; David, JP; Lima-Júnior, RC; Maia, JL; Melo, CM; Rao, VS; Santos, FA | 1 |
| Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O | 1 |
| Cichewicz, DL; Haller, VL; Welch, SP | 1 |
| Kumar, K; Polston, GR; Wallace, MS | 1 |
| Chen, CW; Chen, SC; Liu, BC; Wu, FS | 1 |
| Basbaum, AI; Eckert, WA; Julius, D | 1 |
| Ericson, MB; Gudmundson, F; Karlsson, M; Larkö, O; Ros, AM; Rosdahl, I; Sandberg, C; Stenquist, B; Synnerstad, I; Wennberg, AM | 1 |
| Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C | 1 |
| Ispirescu, JS; Scanlon, GC; Schulteis, G; Wallace, MS | 1 |
| Christoph, T; Erdmann, VA; Frank, R; Gillen, C; Grünweller, A; Kurreck, J; Mika, J; Schäfer, MK; Wade, EJ; Weihe, E | 1 |
| Calixto, JB; Kaster, MP; Mantovani, M; Pertile, R; Rodrigues, AL; Santos, AR | 1 |
| Choi, W; Faltynek, CR; Han, P; Kroeger, PE; McDonald, HA; Moreland, RB; Neelands, TR; Puttfarcken, PS; Vos, MH | 1 |
| Belmonte, C; Carreño, C; Fernández-Carvajal, A; Ferrer-Montiel, A; Ferroni, S; García-Martínez, C; Gomis, A; Valenzuela, B; Van Den Nest, W | 1 |
| Ahern, GP; Matta, JA; Miyares, RL | 1 |
| Chabot, JG; Ma, W; Quirion, R | 1 |
| Li, J; Xing, J | 1 |
| Sun, R; Willis, WD; Yan, J | 1 |
| Baad-Hansen, L; Brandsborg, B; Jensen, TS; Juhl, GI; Svensson, P | 1 |
| Ko, SW; Steenland, HW; Wu, LJ; Zhuo, M | 1 |
| Amadesi, S; Bunnett, N; Hu, WP; Li, JD; Luo, ZD; Zhang, C; Zhou, QY | 1 |
| Chen, SR; Pan, HL; Zhang, HM; Zhou, HY | 2 |
| Frymoyer, AR; Petersen, KL; Rowbotham, MC | 1 |
| Alves, D; Jesse, CR; Nogueira, CW; Pinto, LG; Rocha, JB; Savegnago, L; Zeni, G | 1 |
| Dekowski, B; Frings, S; Funk, K; Gilbert, D; Hagen, V; Keller, S; Lechler, R; Möhrlen, F | 1 |
| Colleoni, M; Comelli, F; Costa, B; Giagnoni, G; Trovato, AE | 1 |
| Fujiyoshi, M; Hayashi, E; Hirano, K; Kinoshita, M; Kuratani, K; Tashiro, N | 1 |
| Barrett, AC; Lomas, LM; Lysle, DT; Picker, MJ; Terner, JM | 1 |
| Baron, R; Binder, A; Hedderich, J; Schattschneider, J; Wasner, G; Zum Buttel, I | 1 |
| Bielefeldt, K; Gebhart, GF; Sugiura, T | 1 |
| Medley, D; Naniwadekar, A; Pasricha, PJ; Shenoy, M; Winston, J | 1 |
| Chung, K; Gao, X; Kim, HK; Mo Chung, J | 1 |
| Ardenghi, JV; De Souza, MM; Filho, VC; Kanegusuku, M; Monache, FD; Niero, R; Yunes, RA | 1 |
| Chong, MS; Hester, J | 1 |
| Premkumar, LS; Sikand, P | 1 |
| Bove, GM; Grigg, P; Robichaud, DR | 1 |
| Birklein, F; Fondel, R; Geber, C; Krämer, HH; Rolke, R; Sommer, C; Treede, RD | 1 |
| Althaus, M; Hanschmann, A; Klein, T; Magerl, W; Treede, RD | 1 |
| Du, D; Eisenach, JC; Liu, B; Tong, C; Yan, T | 1 |
| Chen, M; Gu, JG; Tao, YX | 1 |
| Bianchi, R; Borsani, E; Labanca, M; Rodella, LF | 1 |
| Bíró, T; Dobrosi, N; Géczy, T; Marincsák, R; Paus, R; Tóth, BI | 1 |
| Fachinetto, R; Maffi, LC; Meotti, FC; Missau, FC; Pizzolatti, MG; Rocha, JB; Santos, AR | 1 |
| Bigalke, H; Blersch, W; May, A; Opatz, O; Schulte-Mattler, WJ; Wohlfahrt, K | 1 |
| Atkinson, R; Carroll, W; Chapman, M; Chu, K; Drizin, I; Faltynek, CR; Gauvin, D; Gregg, R; Gross, M; Hakeem, A; Hernandez, G; Honore, P; Jarvis, MF; Johnson, M; Joshi, S; Kort, M; Krafte, DS; Krambis, M; Liu, D; Liu, Y; Marron, B; Marsh, K; Matulenko, M; McGaraughty, S; Mikusa, JP; Pai, M; Roeloffs, R; Scanio, M; Shi, L; Shieh, CC; Sullivan, JP; Thomas, J; Wade, C; Wagoner, PK; Zhang, XF; Zhong, C; Zhu, C | 1 |
| Westaway, SM | 1 |
| Constandil, L; Espinosa, J; Hernández, A; Infante, C; Lapeyra, CD; Pelissier, T | 1 |
| Fairbanks, CA; Goracke-Postle, CJ; Overland, AC; Riedl, MS; Stone, LS | 1 |
| Kaneko, S; Maeda, S; Minami, M; Nakagawa, T; Satoh, M; Wakamatsu, K; Zhang, N | 1 |
| de Tommaso, M; Difruscolo, O; Lamberti, P; Libro, G; Livrea, P; Pecoraro, C; Sardaro, M; Serpino, C | 1 |
| Babai, N; Budai, D; Jósvay, K; Letoha, T; Oláh, Z; Otvös, F; Pecze, L; Szalma, S; Vizler, C | 1 |
| Akopian, AN; Hargreaves, KM; Patwardhan, AM; Ruparel, NB | 1 |
| de Tommaso, M; Di Fruscolo, O; Lamberti, P; Livrea, P; Pecoraro, C; Sardaro, M; Serpino, C | 1 |
| D'Arcy, Y; McCarberg, B | 1 |
| Balla, A; Balla, T; Lukacs, V; Rohacs, T; Thyagarajan, B; Varnai, P | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Rocha, JB; Savegnago, L; Zeni, G | 1 |
| Arik, L; Bak, A; Bannon, AW; Davis, J; Ernst, N; Gavva, NR; Henley, C; Hever, G; Hovland, DN; Immke, DC; Klionsky, L; Kuang, R; Lehto, SG; Louis, JC; Magal, E; Norman, MH; Shi, L; Surapaneni, S; Tamir, R; Treanor, JJ; Wang, J; Wang, W; Zajic, G; Zhu, D | 1 |
| Furue, H; Hasegawa, S; Inoue, K; Ishii, S; Koizumi, S; Masuda, T; Nagata, K; Nakamura, K; Shimizu, T; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T; Yoshimura, M | 1 |
| Dolly, JO; Lawrence, G; Meng, J; Wang, J | 1 |
| Gover, TD; Veiga Moreira, TH; Weinreich, D | 1 |
| Robinson-Papp, J; Simpson, DM | 1 |
| McCleskey, EW | 1 |
| Bean, BP; Binshtok, AM; Woolf, CJ | 1 |
| Agarwal, A; Dhiraaj, S; Gupta, D; Singh, PK; Tandon, M; Yadav, G | 1 |
| Brown, SJ; Estanislao, L; Sampson, J; Simpson, DM | 1 |
| Chen, YF; Jiao, YL; Li, N; Qin, LP; Rahman, K; Wei, P; Zhang, QY; Zheng, HC | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Savegnago, L | 1 |
| Büsselberg, D; Hagenacker, T | 1 |
| Abramson, I; Atkinson, JH; Bentley, H; Gouaux, B; Lazzaretto, D; Schulteis, G; Wallace, M; Wolfson, T | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Ahmadi, S; Brockhaus, J; Brune, K; Fritschy, JM; Hess, A; Hösl, K; Knabl, J; Möhler, H; Reinold, H; Rudolph, U; Sergejeva, M; Witschi, R; Zeilhofer, HU; Zeilhofer, UB | 1 |
| Brito, GA; Chaves, MH; Cunha, GM; Lima-Júnior, RC; Rao, VS; Santos, FA; Sousa, DI | 1 |
| Iannetti, GD; Mitsis, GD; Smart, TS; Tracey, I; Wise, RG | 1 |
| Imagawa, T; Ito, S; Ohta, T | 1 |
| Brand, A; Erdmann, B; Heppenstall, PA; Hu, J; Jüttner, R; Laurito, CE; Lewin, GR; Lu, Y; Milenkovic, N; Park, TJ; Smith, ES; Wetzel, C; Wilson, SP | 1 |
| Akopian, AN; Hargreaves, KM; Patwardhan, A; Ruparel, NB | 1 |
| Remadevi, R; Szallisi, A | 1 |
| Andrade, EL; Calixto, JB; Ferreira, J; Luiz, AP | 1 |
| Helmchen, C; Leyendecker, S; Mohr, C | 1 |
| Chen, S; Guo, M; Liu, XM; Wang, ST | 1 |
| Albers, KM; Davis, BM; Koerber, RH; Malin, SA; Molliver, DC; Reynolds, IJ | 1 |
| Gold, MS; Lu, SG | 1 |
| Caterina, MJ; Chung, MK; Güler, AD | 1 |
| Leon-Sarmiento, FE; Ruiz, S; Schroeder, N | 1 |
| Bautista, D; Julius, D | 1 |
| Hironaka, K; Ogino, A; Ozaki, N; Shinoda, M; Sugiura, Y; Urano, H; Yasui, M | 1 |
| Kim, MS; Medvedeva, YV; Usachev, YM | 1 |
| Palecek, J; Spicarová, D | 1 |
| Benedikt, J; Nováková-Tousová, K; Samad, A; Touska, F; Vlachová, V; Vyklický, L | 1 |
| Burchiel, KJ; Russell, LC | 1 |
| Faulkner, DC; Growcott, JW | 1 |
| Nagy, JI; van der Kooy, D | 1 |
| Gamse, R; Jessell, TM; Leeman, SE; Mudge, AW; Yaksh, TL | 1 |
| Jessell, TM | 1 |
| Emson, PC; Iversen, LL; Nagy, JI | 1 |
| Carpenter, SE; Lynn, B | 1 |
| Buck, SH; Burks, TF; Deshmukh, PP; Miller, MS; Yamamura, HI | 1 |
| Folkers, K; Horig, J; Piercey, MF; Schroeder, LA; Xu, JC | 1 |
| Gamse, R | 1 |
| Fitzgerald, M; Wall, PD | 1 |
| Kongsamut, S; Monsereenusorn, Y; Pezalla, PD | 1 |
| Henry, JL; Wright, DM; Yasphal, K | 1 |
| Baccaglini, PI; Hogan, PG | 1 |
| Abay, EO; Go, VL; Micevych, PE; Schmauss, C; Yaksh, TL | 1 |
| Fitzgerald, M | 1 |
| Bervoets, K; Colpaert, FC | 1 |
| Go, VL; Harty, G; Jhamandas, K; Szolcsanyi, J; Yaksh, TL | 1 |
| Dalsgaard, CJ; Dockray, GJ; Elde, R; Gustafsson, L; Hökfelt, T; Vincent, SR; Wiesenfeld-Hallin, Z | 1 |
| Bittner, MA; Lahann, TR | 1 |
| Kruger, L; Rodin, BE | 1 |
| Hara, A; Kisara, K; Matsumura, H; Sakurada, S; Sakurada, T | 1 |
| Szolcsányi, J | 2 |
| Bodnar, RJ; Kirchgessner, AL; Kordower, JH; Nilaver, G; Simone, DA | 1 |
| Hayes, AG; Oxford, A; Reynolds, M; Shingler, AH; Skingle, M; Smith, C; Tyers, MB | 1 |
| Abbott, FV; Grimes, RW; Melzack, R | 1 |
| Duclaux, R; Saumet, JL | 1 |
| Lembeck, F; Skofitsch, G | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| Cervero, F; McRitchie, HA | 1 |
| Jancsó, G; Jancsó-Gábor, A | 1 |
| Amann, R; Donnerer, J; Holzer, P; Schuligoi, R | 1 |
| Cruwys, SC; Garrett, NE; Kidd, BL | 1 |
| Cutrer, FM; Garret, C; Moskowitz, MA; Moussaoui, S | 1 |
| Hayashi, K; Kuraishi, Y; Nagasawa, T; Satoh, M | 1 |
| Henry, JL; Pitcher, GM; Yashpal, K | 1 |
| Bevan, S; Campbell, EA; Winter, J | 1 |
| Pennefather, J; Roberts, RG; Stevenson, JE; Westerman, RA | 1 |
| Holzer-Petsche, U; Rordorf-Nikolić, T | 1 |
| Cambridge, H | 1 |
| Bennett, DL; McMahon, SB; Priestley, JV; Shelton, DL | 1 |
| Bartoshuk, L; Berger, A; Cooper, D; Duffy, V; Henderson, M; Nadoolman, W; Saberski, L | 1 |
| Campbell, JN; Davis, KD; Filloon, TG; Meyer, RA; Pappagallo, M; Turnquist, JL | 2 |
| Andersson, M; Greiff, L; Persson, CG; Svensson, C | 1 |
| Katsumata, K; Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Ando, R; Kawamura, S; Kume, H; Sakurada, T; Yonezawa, A | 1 |
| Larson, AA; Sun, X | 1 |
| Nagy, J; Pethö, G; Szolcsányi, J | 1 |
| Katsumata, K; Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
| Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Bultitude, MI | 1 |
| Koltzenburg, M; Torebjörk, HE | 1 |
| Kinnman, E; Levine, JD | 1 |
| Grönroos, M; Naukkarinen, H; Pertovaara, A | 1 |
| Lee, SS; Surh, YJ | 1 |
| Anand, P; Jolliffe, VA; Kidd, BL | 1 |
| Bauer, MB; Gebhart, GF; Murphy, S | 1 |
| Han, JS; Hong, SK; Kim, YI; Na, HS | 1 |
| Shuster, S | 1 |
| Hutchison, WD; Lühn, MA; Schmidt, RF | 1 |
| Clarke, IM | 1 |
| Burrows, NP; Norris, PG | 1 |
| Li Wan Po, A; Zhang, WY | 1 |
| Nelson, C | 1 |
| Handwerker, HO; Kilo, S; Koltzenburg, M; Schmelz, M | 1 |
| Belmonte, C; Gallar, J; Garcia de la Rubia, P; Gonzalez, GG | 1 |
| Arndt, JO; Kindgen-Milles, D; Klement, W | 1 |
| Moriya, H; Nakajima, Y; Sakamoto, T; Takahashi, K; Takahashi, Y | 1 |
| Grönroos, M; Pertovaara, A | 1 |
| Chosidow, O; Francès, C; Paul, C | 1 |
| Risberg, T; Wist, E | 1 |
| Barbanti, G; Baroldi, P; Beneforti, P; Maggi, CA; Turini, D | 1 |
| Crain, GM; Gelber, DA; Jung, S; Markwell, SJ; Pfeifer, MA; Ross, DR; Schrage, JP; Schumer, MP | 1 |
| Gainer, H; Kusano, K | 1 |
| Schnitzer, TJ | 1 |
| Del Bianco, E; Fusco, BM; Geppetti, P; Tramontana, M | 1 |
| Hart, MB; Sinoff, SE | 1 |
| Bennett, GJ; Gracely, RH; Max, MB; Park, KM; Robinovitz, E | 1 |
| Inoue, K; Kunimoto, M; Masaki, T; Ogata, K; Takao, F | 1 |
| Calixto, JB; Filho, VC; Santos, AR; Yunes, RA | 1 |
| Andersen, OK; Arendt-Nielsen, L; Jensen, TS | 1 |
| Gur Aryeh, I; Niv, D | 1 |
| Benaim, G; Beneforti, P; Lazzeri, M; Lecci, A; Maggi, CA; Turini, D | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A; Suzuki, T | 1 |
| Chang, WC; Chen, IJ; Tang, CS; Yang, JM; Yang, YC; Yu, KL | 1 |
| Avelino, A; Coimbra, A; Cruz, F | 2 |
| Baumann, TK; Burchiel, KJ; Ingram, SL; Martenson, ME | 1 |
| Grönroos, M; Pertovaara, A; Reunala, T | 1 |
| Bennett, GJ; Gracely, RH; Max, MB; Sang, CN | 1 |
| Christenson, GA; Ristvedt, SL | 1 |
| Kress, M; Schmelz, M | 1 |
| Loomis, CW; Sherman, SE | 1 |
| De Mey, JG; Jacobs, MJ; Kitslaar, PJ; Kurvers, HA; Reneman, RS; Rouwet, EV; Slaaf, DW; Tangelder, GJ; van den Wildenberg, FA | 1 |
| Bennett, GJ; Liu, M; Max, MB; Parada, S; Rowan, JS | 1 |
| Dray, A; Perkins, M | 1 |
| Rees, H; Sluka, KA; Westlund, KN; Willis, WD | 1 |
| Hansson, P; Kinnman, E; Nygårds, EB | 3 |
| Bach, FW | 1 |
| Noda, K; Suzuki, K; Ueda, Y; Yoda, K | 1 |
| Jacknowitz, AI | 1 |
| Goldstein, BD; Yeomans, DC; Zachariou, V | 1 |
| Chen, I; Liu, L; Lo, Y; Simon, SA | 1 |
| Abbadie, C; Basbaum, AI; McKay, WR; Peterson, MA; Rohde, DS; Taylor, BK | 1 |
| Castro-Lopes, JM; Coimbra, A; Pan, B | 1 |
| Fusco, BM; Giacovazzo, M | 1 |
| Curry, R; Eisenach, JC; Hood, DD; Tong, C | 1 |
| Sluka, KA | 2 |
| Sluka, KA; Willis, WD | 1 |
| Goettl, VM; Larson, AA; Larson, DL; Portoghese, PS | 1 |
| Chen, P; Hua, XY; Hwang, J; Yaksh, TL | 1 |
| Calcutt, NA; Hua, XY; Malmberg, AB | 1 |
| Gilhar, A; Markovits, E | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Diop, L; Friese, N; Rivière, PJ | 1 |
| Pirec, V; Proudfit, HK; Yeomans, DC | 1 |
| Plourde, V; Quirion, R; St-Pierre, S | 1 |
| Averbeck, B; Bickel, A; Luz, O; Schmelz, M | 1 |
| Vandam, LD | 1 |
| Kemppainen, P; Könönen, M; Pertovaara, A; Waltimo, A; Waltimo, T | 1 |
| Basbaum, AI; Brandon, EP; Idzerda, RL; Liu, H; Malmberg, AB; McKnight, GS | 1 |
| Calixto, JB; Santos, AR | 2 |
| Allen, BJ; Daughters, RS; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Mantyh, PW; Rogers, SD; Simone, DA; Wiley, RG | 1 |
| Cruwys, S; Garrett, NE; Malcangio, M; Tomlinson, DR | 1 |
| Calixto, JB; Cechinel Filho, V; de Campos, RO; Delle Monache, F; Pinheiro, TR; Pizzolatti, MG; Santos, AR; Vaz, ZR; Yunes, RA | 1 |
| Chiang, CY; Hu, JW; Sessle, BJ | 1 |
| Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M | 1 |
| Andersson, JL; Gordh, T; Handwerker, H; Hartvig, P; Långström, B; Lilja, A; Torebjörk, E | 1 |
| Holst, JJ | 1 |
| Dasgupta, P; Fowler, CJ | 1 |
| Bennett, GJ; Berman, KF; Coghill, RC; Iadarola, MJ; Sang, CN | 1 |
| Acs, G; Acs, P; Biro, T; Blumberg, PM; Modarres, S | 1 |
| Hirano, M; Lincoff, NS; Rath, PP | 1 |
| Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR | 1 |
| Cannon, DT; Wu, Y | 1 |
| Bennett, GJ; Gracely, R; Liu, M; Max, MB; Sethna, NF | 1 |
| Hautkappe, M; Jeffries, JA; Ostermeier, AM; Roizen, MF; Roth, S; Toledano, A | 1 |
| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Andersen, OK; Arendt-Nielsen, L; Kauppila, T; Mohammadian, P; Nielsen, J | 1 |
| Fujibayashi, K; Kubota, K; Saito, K | 1 |
| De Freitas, GA; Santos, AR; Vedana, EM | 1 |
| Heinemann, A; Holzer, P; Jocic, M; Pabst, MA; Schöninkle, E; Schuligoi, R | 1 |
| Arendt-Nielsen, L; Jensen, TS; Svensson, P; Witting, N | 1 |
| Barbacid, M; Belmonte, C; de Castro, F; López de Armentia, M; Silos-Santiago, I | 1 |
| Basbaum, AI; Caterina, MJ; Gilbert, H; Julius, D; Malmberg, AB; Raumann, BE; Rosen, TA; Skinner, K; Tominaga, M | 1 |
| Wei, F | 1 |
| Hunt, SP; Mantyh, PW | 1 |
| Fushiki, T; Inoue, K; Ishihara, K; Kawada, T; Kim, KM | 1 |
| Caruso, R; Chappell, AS; Gracely, RH; Hostetter, MP; Lee, G; Max, MB; Sang, CN; Schoepp, DD; Whitcup, S | 1 |
| Nash, TP; Nurmikko, TJ; Wiles, JR | 1 |
| McCleane, JG; McLaughlin, M | 1 |
| Demuth, HU; Inoue, M; Kisara, K; Nylander, I; Ohshima, K; Sakurada, C; Sakurada, T; Silberring, J; Tadano, T; Taira, A; Tan-No, K; Terenius, L | 1 |
| Liu, L; Simon, SA | 1 |
| Hwang, SW; Jung, JY; Kwak, JY; Lee, WT; Oh, U | 1 |
| Hamilton, SG; McMahon, SB; Wade, A | 1 |
| Ito, S; Minami, T | 1 |
| Baron, R; Jänig, W; Wasner, G | 1 |
| Bian, D; Lai, J; Malan, TP; Ossipov, MH; Porreca, F | 1 |
| Baron, R; Binder, A; Borgstedt, R; Fields, HL; Hastedt, E; Kopper, F; Levine, JD; Rowbotham, M; Schulte, H; Wasner, G | 1 |
| Eherer, AJ; Hammer, HF; Hammer, J; Holzer, P; Krejs, GJ; Petritsch, W | 1 |
| Amanzio, M; Arduino, C; Benedetti, F | 1 |
| Kamei, J; Kashiwazaki, T; Nagase, H; Ohsawa, M | 1 |
| Andrews, K; Baranowski, A; Kinnman, E | 1 |
| Hori, Y; Ito, S; Minami, T; Mishina, M; Okuda-Ashitaka, E; Sakimura, K; Sakuma, S; Sugimoto, T | 1 |
| Chiang, YC; Hu, JW; Sessle, JB; Sunakawa, M | 1 |
| Bengiamin, R; Brennan, J; Bullis, C; Daughters, RS; Li, J; Simone, DA; Stucky, MW | 1 |
| Hazen, E; Johnson, T; Kennedy, WR; Nolano, M; Simone, DA; Wendelschafer-Crabb, G | 1 |
| Mansikka, H; Raja, SN; Shiotani, M; Winchurch, R | 1 |
| Nakamura, A; Shiomi, H | 1 |
| Inoue, M; Ueda, H; Yamada, T | 1 |
| Barrere, C; Friedman, GC; Johnson, RM; Pardinas, JR; Raymon, HK; Sah, DW; Thode, S; Zhou, J | 1 |
| Petersen, KL; Rowbotham, MC | 1 |
| Averbeck, B; Bove, GM; Reeh, PW; Sauer, SK | 1 |
| Cesare, P; McNaughton, PA; Moriondo, A; Vellani, V | 1 |
| Kamei, J; Ohsawa, M | 1 |
| Chen, PS; Neugebauer, V; Willis, WD | 2 |
| Prescott, J | 1 |
| Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D | 1 |
| Hiura, A; Ishizuka, H; Koshigae, Y; Kubo, Y; Nakagawa, H; Yoshizako, A | 1 |
| Baron, R; Baron, Y; Disbrow, E; Roberts, TP | 1 |
| Baumeister, R; Wittenburg, N | 1 |
| Bennett, GJ; Byas-Smith, MG; Dubner, R; Gracely, RH; Max, MB; Robinovitz, E | 1 |
| Calixto, JB; Ferreira, J; Santos, AR | 1 |
| Beydoun, A | 1 |
| Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ | 1 |
| Mendell, LM; Shu, X | 1 |
| Eisenach, JC; Lavand'homme, PM | 1 |
| Barat, M; de Sèze, M; de Sèze, MP; Ferrière, JM; Joseph, PA; Wiart, L | 1 |
| Chiang, CY; Hu, JW; Kwan, CL; Sessle, BJ | 1 |
| Levine, JD; Miao, FJ | 1 |
| Aimi, Y; Kimura, H; Kitajima, K; Nakanishi, Y; Tooyama, I; Yasuhara, O | 1 |
| Baba, H; Brenner, GJ; Ji, RR; Woolf, CJ | 1 |
| Gebhart, GF; Su, X; Wachtel, RE | 1 |
| Inoue, K; Tsuda, M; Ueno, S | 1 |
| Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J | 1 |
| Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH | 1 |
| Baron, R; Binder, A; Kopper, F; Wasner, G | 1 |
| Arendt-Nielsen, L; Gottrup, H; Jensen, TS; Svensson, P; Witting, N | 1 |
| Aikawa, N; Ohmori, K | 1 |
| Armstrong, T; Hayes, M; McLean, AD; Morgans, BT; Tulloch, DN | 1 |
| Handwerker, HO; Schmelz, M; Schmid, R; Torebjörk, HE | 1 |
| Inoue, M; Mishina, M; Ueda, H | 1 |
| Hashimoto, Y; Katsuyama, S; Kuramasu, A; Kutsuwa, M; Lin, ZY; Mobarakeh, JI; Sakurada, S; Watanabe, T; Yanai, K | 1 |
| He, YF; Ichikawa, H; Sugimoto, T | 1 |
| Vizzard, MA | 1 |
| Basbaum, AI; Caterina, MJ; Julius, D; Koltzenburg, M; Leffler, A; Malmberg, AB; Martin, WJ; Petersen-Zeitz, KR; Trafton, J | 1 |
| Ito, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Watanabe, M | 1 |
| Vogel, G | 1 |
| Luger, T; Metze, D; Reimann, S | 1 |
| Atkinson, K; Bingham, S; Clapham, C; Davey, PT; Davis, JB; Grau, E; Gray, J; Gunthorpe, MJ; Harper, AJ; Harries, MH; Hatcher, JP; Hughes, SA; Latcham, J; Overend, P; Pugh, PL; Rance, K; Randall, A; Rogers, DC; Sheardown, SA | 1 |
| Bhattacharjee, A; Hamilton, SG; McMahon, SB; Warburton, J; Ward, J | 1 |
| Cechinel-Filho, V; De Jesus, RA; Oliveira, AE; Schlemper, V | 1 |
| Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C | 1 |
| Regoli, D | 1 |
| Robbins, W | 1 |
| Adelson, DW; Kruger, L; Maidment, NT; Matsuka, Y; Neubert, JK; Spigelman, I | 1 |
| Arendt-Nielsen, L; Graven-Nielsen, T; Sohn, MK; Svensson, P | 1 |
| Carstens, E; Chang, HK; Dessirier, JM; O'Mahony, M | 1 |
| Burritt, A; Hruby, VJ; Ko, MC; Willmont, KJ; Woods, JH | 1 |
| Kubota, K | 1 |
| Choi, S; Chung, S; Hahn, JH; Kim, YI; Nah, JJ; Nah, SY | 1 |
| Calixto, JB; De Campos, RO; Filho, VC; Miguel, OG; Santos, AR; Siani, AC; Yunes, RA | 1 |
| Feher, MD; McIntosh, C; Munro, N; Riche, N | 1 |
| Hiura, A; Kubo, Y; Nakagawa, H | 1 |
| Aracil, A; Belmonte, C; Ferrer-Montiel, AV; Gallar, J; González-Ros, JM; Merino, JM; Pérez-Payá, E; Planells-Cases, R | 1 |
| Dahl, JB; Dirks, J; Fabricius, P; Petersen, KL; Rowbotham, MC | 1 |
| Calixto, JB; Cechinel Filho, V; Luzzi, R; Niero, R; Roos, JF; Santos, AR; Scheidt, C; Yunes, RA | 1 |
| Hazato, T; Inoue, M; Matsunaga, S; Ueda, H; Yamamoto, Y | 1 |
| Brennum, J; Fields, HL; Petersen, KL; Rowbotham, MC; Sandroni, P | 1 |
| Cohen, JS | 1 |
| Cooper, BY; Gu, JG; Johnson, RD; Napaporn, J; Petruska, JC | 1 |
| Buchheit, KH; Campbell, EA; Chaudhry, N; James, IF; Kane, S; Panesar, M; Patel, S; Sandells, B; Urban, L | 1 |
| Foged, C; Thomsen, C; Tullin, S; Wahl, P | 1 |
| Arendt-Nielsen, L; Curatolo, M; Petersen-Felix, S | 1 |
| Arndt, J; Holthusen, H | 1 |
| Handevidt, F | 1 |
| Bantel, C; Bürkle, H; Henningsen, H; Imai, T; Knecht, S; Lütkenhöner, B; Pantev, C; Sörös, P; Wüsten, R | 1 |
| Kamei, J; Zushida, K | 1 |
| Brandt, MR; Furness, MS; Mello, NK; Negus, SS; Rice, KC | 1 |
| Inoue, K; Koizumi, S; Tsuda, M | 1 |
| Blakeman, KH; Ernfors, P; Hao, JX; Hassani, H; Lucas, G; Naveilhan, P; Thorén, P; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Itoh, M; Konemura, T; Kuraishi, Y; Sasaki, M; Sasamura, T; Tohda, C | 1 |
| Ito, S; Matsumura, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Shimamoto, K | 1 |
| Ando, R; Kawamura, S; Sakurada, T; Watanabe, C; Yonezawa, A | 1 |
| Flores, CM; Goodis, HE; Harding-Rose, CA; Hargreaves, KM; Ulrich-Lai, YM | 1 |
| Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM | 1 |
| Caterina, MJ; Julius, D | 1 |
| Drummond, PD; Wright, BR | 1 |
| Fukui, H; Kashiba, H; Senba, E | 1 |
| Masu, M; Tominaga, M; Wada, M | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JMA; Martinez-Caro, L | 1 |
| Greffrath, W; Kirschstein, T; Nawrath, H; Treede, R | 1 |
| Chancellor, MB; de Groat, WC; Fink, J; Franks, ME; Fraser, MO; Glorioso, J; Goins, WF; Goss, J; Sasaki, K; Seki, S; Yokoyama, T; Yoshimura, N | 1 |
| Choi, SS; Chung, KM; Lee, KC; Suh, HW | 1 |
| Avidan, A | 1 |
| Kang, YM; Pickar, JG; Wheeler, JD | 1 |
| Bakoshi, S; Ito, S; Minami, T; Mine, O; Mori, H; Muratani, T; Nakano, H | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Fuchs, PN; Magerl, W; Meyer, RA; Treede, RD | 1 |
| Cai, Y; Kovacs, KJ; Larson, AA | 1 |
| Drummond, PD; Lipnicki, DM | 1 |
| Dahl, JB; Dirks, J; Fabricius, P; Mikkelsen, S; Petersen, KL; Rowbotham, MC | 1 |
| Kohama, K; Nakamura, A; Shirakura, K; Sudo, M; Takagishi, K; Tomioka, A; Tsutsumi, S | 1 |
| Docherty, JC; Malisza, KL | 1 |
| Aglioti, S; Farina, S; Fiaschi, A; Rosso, T; Tamburin, S; Tinazzi, M; Valeriani, M | 1 |
| Hoogerwerf, WA; Lee-Hellmich, H; Micci, MA; Pasricha, PJ; Shenoy, M; Sun, D; Winston, JH; Xiao, SY; Zou, L | 1 |
| Bove, GM; Reeh, PW; Sauer, SK | 1 |
| Hu, Q; Kurihara, T; Ogasawara, M; Tanabe, T | 1 |
| Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A | 1 |
| Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Toriyabe, M | 1 |
| Afrah, AW; Brodin, E; Gustafsson, H; Olgart, L; Stiller, CO | 1 |
| Baranowski, AP; Harding, LM; Kinnman, E; Murphy, A | 1 |
| Dallel, R; Dubray, C; Ngom, PI; Woda, A | 1 |
| Amuzescu, B; Babes, A; Flonta, ML; Krause, U; Reid, G; Scholz, A | 1 |
| Eltorp, CT; Hansen, AJ; Ingvardsen, BK; Jørgensen, TK; Lundbaek, JA; Olsen, UB; Thomsen, C | 1 |
| Choi, S; Jung, SY; Ko, YS; Koh, SR; Nah, SY; Oh, JW; Oh, S; Oh, U; Park, CS; Rhee, MH | 1 |
| Greffrath, W; Kirschstein, T; Nawrath, H; Treede, RD | 1 |
| Belmonte, C; Caprini, M; Carbonell, T; De Felipe, C; De La Pena, E; Ferrer-Montiel, A; García-Martinez, C; Gomis, A; Humet, M; Messeguer, A; Pérez-Paya, E; Planells-Cases, R; Sanchez-Baeza, F; Viana, F | 1 |
| Ko, MC; McKnight, AT; Naughton, NN; Rice, KC; Song, MS; Traynor, JR; Woods, JH | 1 |
| Chen, J; Furue, H; Kumamoto, E; Luo, C; Yoshimura, M | 1 |
| Carstens, E; Jinks, SL | 1 |
| Doom, CM; Junger, H; Sorkin, LS; Yu, AL | 1 |
| Furness, JB; Khalil, Z; Kumano, K; Sanger, GJ; Timar-Peregrin, A | 1 |
| Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH | 1 |
| McCleane, GJ; Walker, RA | 1 |
| Baker, D; Bifulco, M; Bisogno, T; Bridges, D; Brooks, JW; Brown, P; Di Marzo, V; Hankey, DJ; Jaggar, SI; Ledent, C; Pryce, G; Rice, AS | 1 |
| Berrino, L; Cuomo, D; de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F | 1 |
| Palecek, J; Paleckova, V; Willis, WD | 1 |
| Willis, WD | 2 |
| Inoue, K; Iwanaga, T; Koizumi, S; Shigemoto-Mogami, Y; Tsuda, M; Ueda, H; Ueno, S | 1 |
| Bortolotti, M; Coccia, G; Grossi, G; Miglioli, M | 1 |
| Adhikari, SM; Kokayeff, A; Lariviere, WR; Laughlin, TM; Mogil, JS; Wan, Y; West, EE; Wilson, SG | 1 |
| Andersson, DA; Hogestatt, ED; Zygmunt, PM | 1 |
| Chapman, V; Kelly, S | 1 |
| Arendt-Nielsen, L; Cruccu, G; Romaniello, A; Svensson, P | 1 |
| Farb, DH; Jessell, TM; Leeman, SE; Yaksh, TL | 1 |
| Gamse, R; Holzer, P; Jurna, I; Lembeck, F | 1 |
| Benedek, G; Jancsó-Gábor, A; Obál, F | 1 |
| Jancsó-Gábor, A; Szolcsányi, J | 2 |
| Jancsó, G; Knyihár, E | 1 |
| Gebhart, GF; Maves, TJ; Meller, ST | 1 |
| Loomis, CW; Sherman, SE; Vyas, D | 1 |
| Church, MK; Holgate, ST; Howarth, PH; Lau, LC; Polosa, R; Rajakulasingam, K | 1 |
| Dray, A | 1 |
| Yaksh, TL; Yamamoto, T | 1 |
| Ollat, H | 1 |
| Ballejo, G; Corrado, AP | 1 |
| McCarthy, GM; McCarty, DJ | 1 |
| Boulton, AJ; Veves, A | 1 |
| Maggi, CA | 1 |
| Koltzenburg, M; Lundberg, LER; Torebjörk, EH | 1 |
| Bauer, MB; Gebhart, GF; Meller, ST | 1 |
| Arroyo, JF; Cohen, ML | 1 |
| Alessandri, M; Fusco, BM | 1 |
| Rumsfield, JA; West, DP | 1 |
| Arroyo, JF | 1 |
| Dubner, R | 1 |
| Coderre, TJ; Melzack, R | 2 |
| Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 2 |
| Cao, W; Deng, Y; Dong, X; Lu, Z; Zhang, T | 1 |
| Braun, KP; Goodman, M; Jang, JD; Nishiuchi, Y; Ro, SG; Yaksh, TL | 1 |
| Brody, MJ; Gebhart, GF; Lewis, SJ; Meller, ST; Ness, TJ | 1 |
| Dickenson, AH | 1 |
| Amann, R; Donnerer, J; Lembeck, F | 1 |
| Fujita, H; Kawabata, S; Kuraishi, Y; Matsumoto, T; Nakamura, A; Satoh, M | 1 |
| Bevan, S; Dray, A; Rang, HP | 1 |
| Dickenson, A; Dray, A | 1 |
| Hentrich, M; Ochs, G; Peikert, A | 1 |
| Ochoa, J; Simone, DA | 1 |
| Engberg, G; Hajòs, M | 2 |
| Gebhart, GF; Ness, TJ; Randich, A | 1 |
| Otten, U; Vedder, H | 1 |
| Alessandri, M; Drapeau, G; Fanciullacci, M; Fusco, BM; Geppetti, P; Maggi, CA; Regoli, D; Tramontana, M | 1 |
| Basha, KM; Whitehouse, FW | 1 |
| Li, R; Yu, YX | 1 |
| LaMotte, RH; Shain, CN; Simone, DA; Tsai, EF | 1 |
| Baumann, TK; LaMotte, RH; Shain, CN; Simone, DA | 1 |
| Lipton, MN; Scheffler, NM; Sheitel, PL | 1 |
| Bjerring, P | 1 |
| Henkin, R | 1 |
| Blumberg, PM; Joo, F; Szallasi, A; Szallasi, Z; Szolcsanyi, J | 1 |
| Abraham, RR; Levy, DM; Tomlinson, DR | 1 |
| Buzzi, MG; Chudler, EH; Moskowitz, MA; Nishimori, T; Poletti, CE; Uhl, GR | 1 |
| Ai, M; Guan, X; Liang, X; Zhang, Y; Zhang, Z | 1 |
| Ji, C; Li, C; Li, W; Yang, B; Zhu, L | 1 |
| Gibson, SJ; Helme, RD; LeVasseur, SA | 1 |
| Lynn, B | 1 |
| Blumberg, PM; Szallasi, A | 2 |
| Seltzer, Z; Shir, Y | 1 |
| Hurwitz, BJ; Massey, EW; Morgenlander, JC | 1 |
| Knyazev, GG; Knyazeva, GB; Nikiforov, AF | 1 |
| Girolomoni, G; Tigelaar, RE | 1 |
| Fasmer, OB; Hole, K; Hunskaar, S | 1 |
| Bernard, C; Chayvialle, JA; Chéry-Croze, S; Godinot, F; Jourdan, G | 1 |
| Blinn, JR; Dobry-Schreur, PJ; Moon, MW; Piercey, MF | 1 |
| Fujii, N; Oku, R; Otaka, A; Satoh, M; Takagi, H; Yajima, H | 1 |
| Harti, G; Pierau, FK; Sann, H; Simon, E | 1 |
| Bossut, D; Frenk, H; Mayer, DJ; Urca, G | 1 |
| Aoki, M; Harada, Y; Namiki, A; Shimizu, H; Tsukamoto, T | 1 |
| Komisaruk, BR; Martinez-Gomez, M; Oliva-Zarate, L; Pacheco, P; Whipple, B | 1 |
| Bortolami, R; Carobi, C; Draicchio, F; Grassi, S; Lucchi, ML; Manni, E; Pettorossi, VE | 1 |
| Bettaney, J; Dray, A; Forster, P | 1 |
| Baumann, TK; LaMotte, RH; Simone, DA | 1 |
| Evans, RJ; Watson, CP; Watt, VR | 1 |
| Cline, M; Culp, WJ; Dotson, R; Ochoa, J | 1 |
| Helme, RD | 1 |
| Brini, A; Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Carlsson, A; Hajós, M; Nissbrandt, H; Obál, F; Svensson, K | 1 |
| Hajós, M; Wikberg, JE | 1 |
| Foster, RW; Weston, KM | 1 |
| Aoki, M; Harada, Y; Namiki, A | 1 |
| He, X; Schmidt, RF; Schmittner, H | 1 |
| Fanciullacci, M; Fusco, BM; Geppetti, P; Maggi, CA; Marabini, S; Sicuteri, F | 1 |
| Abelli, L; Alessandri, M; Conte, B; Geppetti, P; Giuliani, S; Maggi, CA; Meli, A; Somma, V; Theodorsson, E | 1 |
| Coderre, TJ; Grimes, RW; Melzack, R | 1 |
| Andoh, R; Kisara, K; Miyagawa, T; Osawa, K; Sakurada, S; Sakurada, T | 1 |
| Eimerl, D; Papir-Kricheli, D | 1 |
| Diamond, J; Doucette, R; Theriault, E | 1 |
| LaMotte, RH; Ngeow, JY; Putterman, GJ; Simone, DA | 1 |
| Amann, R; Barthó, L; Lembeck, F; Saria, A; Szolcsányi, J | 1 |
| Pierau, FK; Sann, H; Szolcsányi, J | 1 |
| Saporta, S | 1 |
| Nakahama, H; Niizuma, H; Otsuki, T; Suzuki, J | 1 |
| Chung, JM; Hori, Y; Lee, KH; Willis, WD | 1 |
| Andoh, R; Fujii, T; Kisara, K; Sakurada, S; Sakurada, T; Yonezawa, A | 1 |
| Helme, RD; McKernan, S | 1 |
103 review(s) available for capsaicin and Ache
| Article | Year |
|---|---|
Nobel somatosensations and pain.
Topics: Capsaicin; Humans; Hyperalgesia; Ion Channels; Nobel Prize; Pain; Temperature; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
Anti-cancer activity of sustained release capsaicin formulations.
Topics: Antineoplastic Agents; Capsaicin; Delayed-Action Preparations; Humans; Neoplasms; Pain | 2022 |
Beneficial Effects of Capsaicin in Disorders of the Central Nervous System.
Topics: Animals; Capsaicin; Central Nervous System; Pain; Stroke; TRPV Cation Channels | 2022 |
Capsaicin, its clinical significance in patients with painful diabetic neuropathy.
Topics: Administration, Topical; Capsaicin; Diabetes Mellitus; Diabetic Neuropathies; Humans; Pain; Quality of Life | 2022 |
Painful diabetic peripheral neuropathy of the feet: integrating prescription-strength capsaicin into office procedures.
Topics: Administration, Cutaneous; Administration, Topical; Capsaicin; Diabetes Mellitus; Diabetic Neuropathies; Humans; Pain | 2023 |
Comprehensive insights into the multifaceted roles of the transient receptor potential vanilloid 1 channel in the digestive system.
Topics: Animals; Antineoplastic Agents; Capsaicin; Digestive System; Humans; Mammals; Pain; Transient Receptor Potential Channels; TRPV Cation Channels | 2023 |
Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities.
Topics: Animals; Capsaicin; Humans; Neoplasms; Pain; Signal Transduction; TRPV Cation Channels | 2020 |
Evaluation of the efficacy of treatment modalities in burning mouth syndrome-A systematic review.
Topics: Analgesics; Anticonvulsants; Burning Mouth Syndrome; Capsaicin; Humans; Pain | 2020 |
Temperature-sensitive transient receptor potential vanilloid channels: structural insights into ligand-dependent activation.
Topics: Capsaicin; Humans; Ligands; Pain; Temperature; Transient Receptor Potential Channels | 2022 |
TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential.
Topics: Animals; Capsaicin; Humans; Ligands; Pain; Protein Conformation; TRPV Cation Channels | 2021 |
A systematic review of treatment for patients with burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Clonazepam; Humans; Pain; Thioctic Acid | 2022 |
Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review.
Topics: Burning Mouth Syndrome; Capsaicin; Cytokines; Humans; Low-Level Light Therapy; Neuralgia; Pain; Pain Measurement; Pain Threshold; Perception; Physical Stimulation; Sensory Thresholds; Surveys and Questionnaires; Thioctic Acid | 2021 |
[Pain - The most interesting new findings in the last ten years].
Topics: Calcitonin Gene-Related Peptide; Capsaicin; Humans; Pain; Pain Management | 2018 |
Transient receptor potential vanilloid 1 as a therapeutic target in analgesia.
Topics: Analgesics; Animals; Burns, Chemical; Capsaicin; Drug Design; Fever; Humans; Ligands; Pain; Sensory Receptor Cells; TRPV Cation Channels | 2013 |
Qutenza (capsaicin) 8% patch onset and duration of response and effects of multiple treatments in neuropathic pain patients.
Topics: Adult; Aged; Aged, 80 and over; Capsaicin; Databases, Factual; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; HIV Infections; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain; Pain Measurement; Randomized Controlled Trials as Topic; Sensory System Agents; Time Factors; Transdermal Patch; Young Adult | 2014 |
Mechanisms and clinical uses of capsaicin.
Topics: Analgesics; Animals; Capsaicin; Cardiovascular System; Gastrointestinal Tract; Humans; Neoplasms; Obesity; Pain; Skin Diseases; Urinary Bladder | 2013 |
Capsaicin-based therapies for pain control.
Topics: Animals; Capsaicin; Humans; Neuralgia; Nociception; Pain; TRPV Cation Channels | 2014 |
Zucapsaicin for the treatment of neuropathic pain.
Topics: Adult; Analgesics; Animals; Capsaicin; Headache; Humans; Neuralgia; Osteoarthritis, Knee; Pain; Severity of Illness Index | 2014 |
Pharmacologic interventions for painful diabetic neuropathy: An umbrella systematic review and comparative effectiveness network meta-analysis.
Topics: Analgesics, Opioid; Anticonvulsants; Antidepressive Agents, Tricyclic; Bias; Capsaicin; Diabetic Neuropathies; Humans; Pain; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors | 2014 |
Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses.
Topics: Analgesics; Analgesics, Opioid; Animals; Capsaicin; Humans; Ketamine; Pain; Pain Measurement; Respiratory Insufficiency | 2015 |
A Mechanism-Based Approach to the Management of Osteoarthritis Pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement; Capsaicin; Catastrophization; Central Nervous System Sensitization; Cognitive Behavioral Therapy; Depression; Exercise Therapy; Glucosamine; Humans; Hyaluronic Acid; Nerve Growth Factor; Osteoarthritis; Pain; Pain Management; Physical Therapy Modalities; Platelet-Rich Plasma; Sensory System Agents; Sleep Wake Disorders; Viscosupplements | 2015 |
Assessment of Itch and Pain in Animal Models and Human Subjects.
Topics: Analgesics; Animals; Antipruritics; Avoidance Learning; Capsaicin; Conditioning, Classical; Emotions; Histamine; Histamine Antagonists; Humans; Mice; Models, Animal; Nociception; Nontherapeutic Human Experimentation; Organ Specificity; Pain; Pain Measurement; Physical Stimulation; Pruritus; Rats; Species Specificity | 2016 |
A systematic review of randomized trials for the treatment of burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Humans; Pain; Pain Management; Pain Measurement; Psychotherapy; Quality of Life; Randomized Controlled Trials as Topic; Thioctic Acid; Treatment Outcome | 2016 |
Capsaicin, Nociception and Pain.
Topics: Analgesics; Capsaicin; Humans; Inflammation; Nociception; Pain; Spinal Cord; TRPV Cation Channels | 2016 |
Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses.
Topics: Analgesics; Animals; Capsaicin; Capsicum; Clinical Studies as Topic; Drug Compounding; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Nociceptors; Pain; Plant Extracts | 2016 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Biofeedback, Psychology; Capsaicin; Cognitive Behavioral Therapy; Europe; Evidence-Based Medicine; Exercise Therapy; Fatigue; Fibromyalgia; Human Growth Hormone; Humans; Hydrotherapy; Hypnosis; Manipulation, Chiropractic; Massage; Mind-Body Therapies; Mindfulness; Monoamine Oxidase Inhibitors; Pain; Practice Guidelines as Topic; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Sensory System Agents; Serotonin and Noradrenaline Reuptake Inhibitors; Sleep; Societies, Medical; Sodium Oxybate; Treatment Outcome | 2017 |
Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases.
Topics: Capsaicin; Capsicum; Clinical Trials as Topic; Humans; Molecular Structure; Pain; Sensory System Agents; Signal Transduction; Structure-Activity Relationship; TRPV Cation Channels | 2016 |
The functional regulation of TRPV1 and its role in pain sensitization.
Topics: Animals; Capsaicin; Diterpenes; Pain; Protein Kinases; TRPV Cation Channels | 2008 |
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks.
Topics: Analgesics; Animals; Capsaicin; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Nervous System; Neuropharmacology; Nociceptors; Pain; TRPV Cation Channels | 2009 |
Loin pain hematuria syndrome: a psychiatric and surgical conundrum.
Topics: Capsaicin; Denervation; Diagnosis, Differential; Hematuria; Humans; Kidney Diseases; Kidney Transplantation; Pain; Risk Assessment; Risk Factors; Somatoform Disorders; Syndrome; Transplantation, Autologous; Treatment Outcome | 2009 |
Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors.
Topics: Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Hindlimb; Injections, Intralesional; Mice; Molecular Structure; Monoterpenes; Oils, Volatile; Pain; Plant Oils | 2009 |
Painful diabetic neuropathy: advantage of novel drugs over old drugs?
Topics: Amitriptyline; Analgesics; Antioxidants; Antipruritics; Capsaicin; Chronic Disease; Diabetic Neuropathies; Humans; Hypoglycemic Agents; Insulin; Pain; Selective Serotonin Reuptake Inhibitors; Thioctic Acid | 2009 |
Topical capsaicin. The fire of a 'hot' medicine is reignited.
Topics: Administration, Topical; Antipruritics; Capsaicin; Humans; Pain; Pruritus; Sensory System Agents; TRPV Cation Channels | 2010 |
Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials.
Topics: Animals; Capsaicin; Clinical Trials as Topic; Diterpenes; Drug Evaluation, Preclinical; Humans; Pain; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
The vanilloid agonist resiniferatoxin for interventional-based pain control.
Topics: Animals; Capsaicin; Diterpenes; Humans; Pain; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch.
Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Humans; Hyperalgesia; Nociceptors; Pain | 2011 |
Interventional management of cancer pain.
Topics: Analgesia; Capsaicin; Catheter Ablation; Humans; Neoplasms; Pain; Vertebroplasty; World Health Organization | 2012 |
Targeting TRPV1 for pain relief: limits, losers and laurels.
Topics: Analgesics; Animals; Capsaicin; Diterpenes; Drug Delivery Systems; Drug Design; Humans; Pain; TRPV Cation Channels | 2012 |
Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review.
Topics: Analgesics, Non-Narcotic; Arthritis; Capsaicin; Evidence-Based Medicine; Expert Testimony; Humans; International Cooperation; Nefopam; Neurotransmitter Agents; Pain; Pain Management; Randomized Controlled Trials as Topic; Treatment Outcome | 2012 |
Unravelling the mystery of capsaicin: a tool to understand and treat pain.
Topics: Animals; Capsaicin; Gastrointestinal Tract; Humans; Models, Biological; Pain; Respiratory System; Skin; Transient Receptor Potential Channels | 2012 |
Management strategies for the treatment of neuropathic pain in the elderly.
Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Capsaicin; Cognitive Behavioral Therapy; Diabetic Neuropathies; Herpes Simplex; Humans; Lidocaine; Nerve Block; Nervous System Diseases; Neuralgia; Pain; Pain Management; Physical Therapy Modalities; Stroke; Tramadol | 2002 |
The pathogenesis and management of painful diabetic neuropathy: a review.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Antidepressive Agents; Blood Glucose; Capsaicin; Diabetic Foot; Diabetic Neuropathies; Humans; N-Methylaspartate; Pain; Selective Serotonin Reuptake Inhibitors; Transcutaneous Electric Nerve Stimulation | 2003 |
[Capsaicin and its receptor--vanilloid receptor].
Topics: Animals; Capsaicin; Mice; Mice, Knockout; Nociceptors; Pain; Rats; Receptors, Drug | 2003 |
Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain.
Topics: Acute Disease; Adenosine Triphosphate; Afferent Pathways; Analgesics; Animals; Biopolymers; Capsaicin; Chronic Disease; Ganglia, Spinal; Gene Targeting; Humans; Hyperalgesia; Mice; Mice, Knockout; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Neurons; Nociceptors; Pain; Phenotype; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X3 | 2003 |
Transdermal approaches to pain in sports injury management.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Capsaicin; Cryotherapy; Dimethyl Sulfoxide; Electric Stimulation Therapy; Humans; Iontophoresis; Low-Level Light Therapy; Magnetics; Pain; Pain Management; Sports Medicine; Ultrasonic Therapy | 2003 |
Pharmacological management of neuropathic pain.
Topics: Analgesics, Opioid; Anesthetics, Local; Anticonvulsants; Antidepressive Agents, Tricyclic; Baclofen; Capsaicin; Clonidine; Complementary Therapies; Humans; Nervous System; Pain; Selective Serotonin Reuptake Inhibitors | 2003 |
Systematic review of topical capsaicin for the treatment of chronic pain.
Topics: Administration, Topical; Analgesics; Capsaicin; Chronic Disease; Humans; Musculoskeletal Diseases; Neuralgia; Pain; Pain Measurement; Randomized Controlled Trials as Topic; Treatment Outcome | 2004 |
Biochemical pharmacology of the vanilloid receptor TRPV1. An update.
Topics: Animals; Capsaicin; Humans; Inflammation; Models, Molecular; Pain; Receptors, Drug | 2004 |
Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Central Nervous System; Gastrointestinal Tract; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nerve Endings; Nitric Oxide; Pain; Receptors, Drug; Respiratory Physiological Phenomena; Tachykinins; Urogenital System; Viscera | 2004 |
Recent developments in transient receptor potential vanilloid receptor 1 agonist-based therapies.
Topics: Capsaicin; Humans; Pain; Receptors, Drug; Urinary Bladder | 2004 |
Imaging of acute versus pathological pain in humans.
Topics: Acute Disease; Adult; Brain; Capsaicin; Humans; Hyperalgesia; Male; Pain; Physical Stimulation; Positron-Emission Tomography; Reference Values | 2005 |
Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.
Topics: Animals; Biological Products; Calcium Channels; Capsaicin; Diterpenes; Humans; Nociceptors; Pain; Receptors, Drug; Structure-Activity Relationship; TRPC Cation Channels | 2005 |
Topical agents for the treatment of chronic pain.
Topics: Administration, Topical; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chronic Disease; Female; Humans; Male; Middle Aged; Pain | 2006 |
[Potential antinociceptive mechanisms of botulinum toxin].
Topics: Analgesics, Non-Narcotic; Animals; Botulinum Toxins; Botulinum Toxins, Type A; Capsaicin; Cells, Cultured; Disease Models, Animal; Forecasting; Headache; Humans; Migraine Disorders; Models, Biological; Neuromuscular Agents; Neurotoxins; Nociceptors; Pain; Quality of Life; Randomized Controlled Trials as Topic; Rats; Sensory System Agents; Time Factors | 2006 |
Hot receptors in the brain.
Topics: Analgesics, Non-Narcotic; Animals; Brain; Capsaicin; Humans; Pain; TRPV Cation Channels | 2006 |
Diabetic painful neuropathy: current and future treatment options.
Topics: Analgesics, Opioid; Anticonvulsants; Capsaicin; Controlled Clinical Trials as Topic; Diabetes Mellitus; Diabetic Neuropathies; Humans; Hypoglycemic Agents; Pain; Pain Management; Selective Serotonin Reuptake Inhibitors | 2007 |
TRP channels as novel players in the pathogenesis and therapy of itch.
Topics: Animals; Cannabinoids; Capsaicin; Central Nervous System; Histamine; Humans; Inflammation Mediators; Nerve Growth Factors; Neurons; Neurons, Afferent; Neuropeptides; Pain; Pruritus; Spinal Cord; Substance P; Temperature; Transient Receptor Potential Channels; TRPV Cation Channels | 2007 |
The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.
Topics: Analgesics; Animals; Capsaicin; Humans; Pain; TRPV Cation Channels | 2007 |
Target pain with topical peripheral analgesics.
Topics: Administration, Topical; Aged; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Female; Hot Temperature; Humans; Lidocaine; Osteoarthritis, Knee; Pain; Pain Management; Peripheral Nervous System Agents | 2007 |
Safety profile of treatment in diabetic peripheral neuropathic pain.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Capsaicin; Cyclohexanols; Diabetic Neuropathies; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Thiophenes; Venlafaxine Hydrochloride | 2007 |
The role of spinal cord vanilloid (TRPV1) receptors in pain modulation.
Topics: Animals; Capsaicin; Ganglia, Spinal; Humans; Pain; Spinal Cord; Synaptic Transmission; TRPV Cation Channels | 2008 |
Neurophysiological effects of capsaicin.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Capsaicin; Cardiovascular System; Cell Membrane; Digestive System; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Nerve Fibers; Nervous System; Nociceptors; Pain; Rats; Receptors, Opioid; Substance P | 1984 |
The role of substance P in sensory transmission and pain perception.
Topics: Animals; Capsaicin; Ganglia, Spinal; Membrane Potentials; Neurons, Afferent; Neurotransmitter Agents; Pain; Substance P | 1981 |
If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function?
Topics: Action Potentials; Animals; Biological Transport; Capsaicin; Electric Stimulation; Hot Temperature; Models, Biological; Nerve Crush; Neurons, Afferent; Pain; Peripheral Nerve Injuries; Peripheral Nerves; Sensory Receptor Cells; Spinal Cord; Substance P; Synaptic Transmission | 1982 |
Capsaicin--a literature survey.
Topics: Analgesia; Animals; Blood Pressure; Body Temperature Regulation; Capsaicin; Cardiovascular System; Chemical Phenomena; Chemistry; Colon; Dose-Response Relationship, Drug; Drug Tolerance; Fatty Acids, Unsaturated; Heart Rate; Histamine; Intestine, Small; Liver; Muscle, Smooth, Vascular; Myocardial Contraction; Pain; Phagocytosis; Respiratory System; Stomach Ulcer; Substance P; Vagus Nerve | 1982 |
Capsaicin and sensory neurones--a review.
Topics: Animals; Axonal Transport; Axons; Capsaicin; Cholecystokinin; Edema; Fatty Acids, Unsaturated; Ganglia, Spinal; Nerve Degeneration; Nerve Fibers; Neurons, Afferent; Pain; Rats; Reflex; Sensation; Substance P | 1983 |
Deafferentation in animals as a model for the study of pain: an alternative hypothesis.
Topics: Afferent Pathways; Animals; Capsaicin; Denervation; Disease Models, Animal; Formaldehyde; Hydroxydopamines; Neurons, Afferent; Oxidopamine; Pain; Rats; Reptiles; Species Specificity; Spinal Nerve Roots; Spinal Nerves; Tail | 1984 |
Capsaicin and pain mechanisms.
Topics: Analgesia; Animals; Capsaicin; Drug Resistance; Humans; Hyperalgesia; Nerve Degeneration; Nociceptors; Pain; Receptors, Drug | 1995 |
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.
Topics: Animals; Capsaicin; Carcinogens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Humans; Liver; Microsomes, Liver; Mutagenesis; Neoplasms, Experimental; Oxidoreductases, N-Demethylating; Pain | 1995 |
The effectiveness of topically applied capsaicin. A meta-analysis.
Topics: Administration, Topical; Capsaicin; Diabetic Neuropathies; Humans; Osteoarthritis; Pain; Psoriasis | 1994 |
[Capsaicin in dermatology].
Topics: Administration, Topical; Capsaicin; Herpes Zoster; Humans; Nerve Fibers; Pain; Skin; Skin Diseases | 1993 |
[Capsaicin for arthritic pain].
Topics: Analgesics; Animals; Arthritis; Arthritis, Experimental; Capsaicin; Humans; Pain; Substance P | 1996 |
Novel pharmacological strategies for analgesia.
Topics: Bradykinin Receptor Antagonists; Capsaicin; Chronic Disease; Cyclooxygenase Inhibitors; Excitatory Amino Acids; Humans; Nitric Oxide Synthase; Pain; Receptors, Tachykinin | 1996 |
Cooperative mechanisms of neurotransmitter action in central nervous sensitization.
Topics: Animals; Arthritis; Capsaicin; Central Nervous System; Neurotransmitter Agents; Pain | 1996 |
Beta-endorphin in the brain. A role in nociception.
Topics: Animals; beta-Endorphin; Brain; Capsaicin; Electric Stimulation; Excitatory Amino Acid Agonists; Humans; N-Methylaspartate; Pain | 1997 |
Peppers and pain. The promise of capsaicin.
Topics: Analgesics; Animals; Capsaicin; Humans; Medicine, Traditional; Nociceptors; Pain; Plants, Medicinal | 1997 |
Capsaicin--an effective topical treatment in pain.
Topics: Administration, Cutaneous; Analgesics; Capsaicin; Chronic Disease; Diabetic Neuropathies; Herpes Simplex; Humans; Neuralgia; Pain; Rheumatic Diseases | 1997 |
Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin.
Topics: Animals; Capsaicin; Dermatitis; Diterpenes; Ganglia, Spinal; Humans; Neurotoxins; Pain; Radioligand Assay; Receptors, Drug | 1997 |
Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction.
Topics: Capsaicin; Humans; Nervous System Diseases; Pain; Skin Diseases | 1998 |
Recent advances: control of chronic pain.
Topics: Analgesics; Anticonvulsants; Capsaicin; Chronic Disease; Humans; Pain; Stimulation, Chemical | 1998 |
[Biochemistry of pain].
Topics: Afferent Pathways; Animals; Capsaicin; Glutamic Acid; Humans; Narcotics; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Prostaglandins; Spinal Cord; Substance P | 1999 |
Recent advances in neuropharmacology of cutaneous nociceptors.
Topics: Animals; Capsaicin; Humans; Nerve Growth Factors; Neuropharmacology; Nociceptors; Pain; Skin | 1999 |
Ion channels gated by heat.
Topics: Animals; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ion Channel Gating; Ion Channels; Nociceptors; Pain | 1999 |
Postherpetic neuralgia: role of gabapentin and other treatment modalities.
Topics: Acetates; Administration, Topical; Age Factors; Aged; Ambulatory Care; Amines; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Capsaicin; Carbamazepine; Clinical Trials as Topic; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Administration Schedule; Female; Gabapentin; gamma-Aminobutyric Acid; Herpes Zoster; Humans; Male; Middle Aged; Narcotics; Neuralgia; Pain; Risk Factors; Severity of Illness Index; Treatment Outcome | 1999 |
[Intravesical instillations of capsaicin in urology: from pharmacological principles to therapeutic applications].
Topics: Administration, Intravesical; Adolescent; Adult; Aged; Animals; Capsaicin; Cats; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Tolerance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; Rats; Time Factors; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder, Neurogenic; Urinary Incontinence; Urodynamics | 1999 |
Clinical applications of capsaicinoids.
Topics: Capsaicin; Chronic Disease; Humans; Pain | 2000 |
Erythromelalgia: new theories and new therapies.
Topics: Capsaicin; Combined Modality Therapy; Diagnosis, Differential; Erythema; Erythromelalgia; Extremities; Humans; Pain; Prognosis; Temperature; Vascular Diseases | 2000 |
Peripheral neuropathy in persons with diabetes.
Topics: Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Capsaicin; Diabetic Foot; Diabetic Neuropathies; Diagnosis, Differential; Humans; Hypoglycemia; Nursing Care; Pain; Physical Examination; Quality of Life | 2001 |
[ATP receptors in pain].
Topics: Adenosine Triphosphate; Animals; Capsaicin; Electrophysiology; Ganglia, Spinal; Humans; Hyperalgesia; Nociceptors; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2X3; Signal Transduction | 2000 |
Drug treatment of neuropathic pain.
Topics: Aged; Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Capsaicin; Humans; Mexiletine; Nervous System Diseases; Pain; Randomized Controlled Trials as Topic; Treatment Outcome | 2000 |
The vanilloid receptor: a molecular gateway to the pain pathway.
Topics: Animals; Capsaicin; Humans; Mice; Mice, Knockout; Nociceptors; Pain; Receptors, Drug | 2001 |
Role of neurotransmitters in sensitization of pain responses.
Topics: Animals; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Agonists; Haplorhini; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Long-Term Potentiation; Mechanoreceptors; Microdialysis; Models, Animal; Models, Neurological; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Processing, Post-Translational; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Signal Transduction; Spinothalamic Tracts; Substance P | 2001 |
Mechanism of action of capsaicin-like molecules on sensory neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channels; Capsaicin; Cell Membrane; Humans; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Receptors, Drug | 1992 |
[Pharmacological treatment of neuropathic pain].
Topics: Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Baclofen; Capsaicin; Chronic Disease; Diabetic Neuropathies; Humans; Narcotics; Neuralgia; Pain; Peripheral Nervous System Diseases | 1992 |
Therapeutic potential of capsaicin-like molecules: studies in animals and humans.
Topics: Analgesia; Animals; Capsaicin; Cystitis; Humans; Neurons, Afferent; Pain; Pain Threshold; Peripheral Nerves; Receptors, Drug; Urinary Bladder; Urinary Incontinence | 1992 |
Topical capsaicin in dermatologic and peripheral pain disorders.
Topics: Administration, Topical; Capsaicin; Humans; Pain; Peripheral Nervous System Diseases; Skin Diseases | 1991 |
Capsaicin: gaps in our knowledge start to be filled.
Topics: Animals; Axonal Transport; Capsaicin; Nerve Degeneration; Nerve Endings; Nerve Fibers; Nerve Growth Factors; Neurons, Afferent; Pain; Receptors, Drug; Sciatic Nerve; Silver Nitrate; Spinal Cord; Staining and Labeling | 1991 |
Chemical activation of nociceptive peripheral neurones.
Topics: Bradykinin; Calcium-Transporting ATPases; Capsaicin; Humans; Inflammation; Ion Channels; Models, Neurological; Neurons; Nociceptors; Pain; Serotonin | 1991 |
Quantitative monitoring of acute experimental cutaneous pain and inflammatory vascular reactions. Effect of local analgesics, capsaicin and antihistamines.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Dermatitis; Histamine Antagonists; Humans; Nociceptors; Pain; Physical Stimulation; Skin | 1991 |
Capsaicin: actions on nociceptive C-fibres and therapeutic potential.
Topics: Administration, Topical; Animals; Capsaicin; Herpesviridae Infections; Humans; Nerve Block; Nerve Degeneration; Nerve Fibers; Neural Conduction; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Skin | 1990 |
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor.
Topics: Animals; Body Temperature Regulation; Capsaicin; Diterpenes; Nervous System; Nervous System Physiological Phenomena; Neurons, Afferent; Pain; Receptors, Cell Surface; Structure-Activity Relationship | 1990 |
The pain system. The neural basis of nociceptive transmission in the mammalian nervous system.
Topics: Anesthesia; Animals; Brain Stem; Capsaicin; Cerebral Cortex; Digestive System; Electric Stimulation; Electrophysiology; Humans; Mammals; Muscles; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerves; Respiratory System; Skin; Spinal Cord; Synaptic Transmission; Thalamus; Urogenital System | 1985 |
Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain.
Topics: Afferent Pathways; Animals; Behavior, Animal; Capsaicin; Chronic Disease; Denervation; Disease Models, Animal; Electric Stimulation; Evaluation Studies as Topic; Extremities; Guanethidine; Humans; Mice; Norepinephrine; Pain; Rats; Self Mutilation | 1986 |
144 trial(s) available for capsaicin and Ache
| Article | Year |
|---|---|
The Potential Role for Impaired Mucosal Integrity in the Generation of Esophageal Pain Using Capsaicin in Humans: An Explorative Study.
Topics: Capsaicin; Cross-Over Studies; Humans; Mucous Membrane; Pain; Single-Blind Method | 2022 |
Sumatriptan prevents central sensitization specifically in the trigeminal dermatome in humans.
Topics: Capsaicin; Central Nervous System Sensitization; Headache; Humans; Hyperalgesia; Migraine Disorders; Pain; Sumatriptan; Tryptamines | 2022 |
Topical application of isolated menthol and combined menthol-capsaicin creams: Exercise tolerance, thermal perception, pain, attentional focus and thermoregulation in the heat.
Topics: Adult; Body Temperature Regulation; Capsaicin; Cross-Over Studies; Exercise Tolerance; Female; Hot Temperature; Humans; Male; Menthol; Pain; Pain Perception; Thermosensing | 2023 |
Disrupted Cortical Homeostatic Plasticity Due to Prolonged Capsaicin-induced Pain.
Topics: Capsaicin; Chromosomal Proteins, Non-Histone; Evoked Potentials, Motor; Humans; Ice; Neuronal Plasticity; Pain; Transcranial Direct Current Stimulation; Transcranial Magnetic Stimulation | 2023 |
Assessment of Somatosensory Function, Pain, and Unpleasantness in Two Surrogate Models of Trigeminal Nerve Damage: A Randomized, Double-Blind, Controlled Crossover Study.
Topics: Adult; Anesthesia, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Pain; Trigeminal Nerve; Trigeminal Nerve Injuries | 2020 |
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pregabalin; Young Adult | 2020 |
Performance of healthy persons under pain in different cognitive load tasks: An event-related potential study on experimental pain individuals.
Topics: Adolescent; Adult; Capsaicin; Cognition; Electroencephalography; Evoked Potentials; Female; Healthy Volunteers; Humans; Male; Pain; Reaction Time; Young Adult | 2020 |
Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Treatment Outcome | 2021 |
Effect of Topical Analgesia on Desensitization Following 8% Topical Capsaicin Application.
Topics: Administration, Topical; Adult; Anesthetics, Local; Capsaicin; Female; Humans; Lidocaine, Prilocaine Drug Combination; Male; Pain; Pain Measurement; Pruritus; Sensory System Agents; Young Adult | 2021 |
A randomized double blinded placebo controlled study to evaluate motor unit abnormalities after experimentally induced sensitization using capsaicin.
Topics: Adult; Aged; Back Pain; Capsaicin; Central Nervous System Sensitization; Double-Blind Method; Electromyography; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Placebo Effect; Rotator Cuff; Spinal Cord; Superficial Back Muscles; Visual Analog Scale | 2021 |
Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Male; Pain; Pregabalin | 2021 |
Role of capsaicin- and heat-sensitive afferents in stimulation of acupoint-induced pain and analgesia in humans.
Topics: Acupuncture Points; Adolescent; Adult; Afferent Pathways; Capsaicin; Female; Hot Temperature; Humans; Male; Pain; Pain Management; Pain Measurement; Pain Threshold; Saline Solution, Hypertonic; Young Adult | 2017 |
γ-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects.
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healthy Volunteers; Humans; Lidocaine; Male; Mouthwashes; Pain; Pain Management; Pain Measurement; Pain Threshold; Tongue; Young Adult | 2018 |
Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model.
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Nociception; Pain; TRPV Cation Channels; Young Adult | 2018 |
Does Pain Affect Preference? The Effect of Tonic Laboratory Pain on Discounting of Delayed Rewards.
Topics: Capsaicin; Delay Discounting; Female; Humans; Male; Pain; Reward; Sensory System Agents; Young Adult | 2018 |
PIEZO2 mediates injury-induced tactile pain in mice and humans.
Topics: Animals; Capsaicin; Chronic Disease; Disease Models, Animal; Humans; Hyperalgesia; Imaging, Three-Dimensional; Inflammation; Ion Channels; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neurons; Pain; Recombination, Genetic; Touch | 2018 |
No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans.
Topics: Administration, Intranasal; Adult; Capsaicin; Carbon Dioxide; Female; Humans; Irritants; Male; Nasal Mucosa; Pain; Trigeminal Neuralgia; TRPV Cation Channels; Young Adult | 2013 |
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Furans; Ginkgolides; Hindlimb; Hyperalgesia; Inflammation; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sensory System Agents; Vocalization, Animal | 2013 |
Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Capsaicin; Cryotherapy; Double-Blind Method; Female; Follow-Up Studies; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Ointments; Pain; Pain Management; Pain Measurement; Prilocaine; Transdermal Patch; Young Adult | 2013 |
Capsaicin 8% patch for treprostinil subcutaneous infusion site pain in pulmonary hypertension patients.
Topics: Adult; Aged; Antihypertensive Agents; Capsaicin; Double-Blind Method; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Infusions, Subcutaneous; London; Male; Middle Aged; Pain; Sensory System Agents; Transdermal Patch; Treatment Outcome | 2014 |
Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method.
Topics: Adult; Analgesics; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Threshold; Pregabalin; Young Adult | 2014 |
Acute experimentally induced neck pain does not affect fatigability of the peripheral biceps brachii muscle.
Topics: Adult; Arm; Capsaicin; Chronic Pain; Elbow; Elbow Joint; Electromyography; Fatigue; Humans; Isometric Contraction; Male; Muscle Fatigue; Muscle, Skeletal; Neck Pain; Pain; Young Adult | 2014 |
Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin.
Topics: Adult; Capsaicin; Female; Germany; Histamine; Humans; Laser-Doppler Flowmetry; Male; Mucuna; Pain; Pain Measurement; Pain Threshold; Plant Extracts; Pruritus; Regional Blood Flow; Sex Factors; Skin; Surveys and Questionnaires; Time Factors; Young Adult | 2015 |
The effect of experimental pain on motor training performance and sensorimotor integration.
Topics: Adult; Analysis of Variance; Capsaicin; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Male; Median Nerve; Middle Aged; Movement; Pain; Pain Measurement; Psychomotor Performance; Reaction Time; Teaching; Young Adult | 2014 |
Effect of tonic pain on motor acquisition and retention while learning to reach in a force field.
Topics: Adaptation, Physiological; Administration, Topical; Adult; Capsaicin; Exoskeleton Device; Female; Humans; Learning; Male; Pain; Retention, Psychology; Sensory System Agents; Upper Extremity | 2014 |
Effect of written emotional disclosure on secondary hyperalgesia in women with trauma history.
Topics: Adolescent; Adult Survivors of Child Abuse; Bereavement; Capsaicin; Central Nervous System Sensitization; Depression; Disasters; Emotions; Female; Humans; Hyperalgesia; Irritants; Pain; Self Disclosure; Social Problems; Stress, Psychological; Survivors; Wounds and Injuries; Writing; Young Adult | 2014 |
Effect of orally administered potentized capsaicin and dihydrocapsaicin in humans: a homeopathic pathogenetic trial.
Topics: Adolescent; Adult; Capsaicin; Female; Homeopathy; Humans; Male; Middle Aged; Pain; Young Adult | 2014 |
A capsaicin (8%) patch in the treatment of severe persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Capsaicin; Female; Hernia, Inguinal; Humans; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Risk Factors; Skin; Surveys and Questionnaires; Transdermal Patch | 2014 |
A randomized, double-blind, crossover study to evaluate the depth response relationship of intradermal capsaicin-induced pain and hyperalgesia in healthy adult volunteers.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Sensory System Agents; Young Adult | 2015 |
Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; Cell Line; Chalcones; Cyclohexanols; Dinoprostone; Dipeptides; Dose-Response Relationship, Drug; Drug Combinations; Erythema; Facial Dermatoses; Female; Humans; Male; Middle Aged; Neurons; NF-kappa B; Pain; Sensation Disorders; Signal Transduction; Single-Blind Method; Skin Cream; Swine; TRPV Cation Channels; Young Adult | 2016 |
Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin.
Topics: Adult; Aged; Capsaicin; Cosmetics; Cyclohexanols; Dipeptides; Facial Dermatoses; Female; Humans; Middle Aged; Pain; Sensation Disorders; Severity of Illness Index; Single-Blind Method; Time Factors; Young Adult | 2016 |
A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the T-Type Calcium Channel Blocker ABT-639 in an Intradermal Capsaicin Experimental Pain Model in Healthy Adults.
Topics: Adult; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Cross-Over Studies; Double-Blind Method; Heterocyclic Compounds, 2-Ring; Humans; Injections, Intradermal; Male; Middle Aged; Pain; Pain Measurement; Pregabalin; Sulfonamides; Young Adult | 2016 |
Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.
Topics: Adolescent; Adult; Aged; Capsaicin; Electric Stimulation; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Psychophysics; Skin; Young Adult | 2016 |
A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile.
Topics: Adolescent; Adult; Aminopyridines; Animals; Capsaicin; Celecoxib; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Ultraviolet Rays; Young Adult | 2016 |
Evaluation of the antihyperalgesic effect of tapentadol in two human evoked pain models - the TapCapMentho pilot trial.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Neuralgia; Pain; Pain Measurement; Pain Threshold; Phenols; Pilot Projects; Tapentadol; Young Adult | 2016 |
Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study.
Topics: Adolescent; Adult; Analgesics; Capsaicin; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Pentoxifylline; Sensory System Agents; Tourniquets; Young Adult | 2016 |
Analgesic effect of topical oral capsaicin gel in burning mouth syndrome.
Topics: Administration, Topical; Adult; Aged; Analgesics; Burning Mouth Syndrome; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Middle Aged; Pain; Pain Measurement; Sensory System Agents; Treatment Outcome; Visual Analog Scale | 2017 |
TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain.
Topics: Acid Sensing Ion Channel Blockers; Acidosis; Adult; Amiloride; Analgesics; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Oximes; Pain; Pain Measurement; Pyrazines; Pyridines; TRPA1 Cation Channel; TRPV Cation Channels | 2017 |
Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Non-Narcotic; Capsaicin; Double-Blind Method; Female; HIV Infections; Humans; Male; Middle Aged; Pain; Pain Measurement; Placebos; Polyneuropathies; Surveys and Questionnaires; Treatment Outcome | 2008 |
Effects of chili on postprandial gastrointestinal symptoms in diarrhoea predominant irritable bowel syndrome: evidence for capsaicin-sensitive visceral nociception hypersensitivity.
Topics: Adult; Aged; Capsaicin; Cross-Over Studies; Diarrhea; Female; Food; Gastrointestinal Transit; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Pain; Pain Measurement; Postprandial Period; Sensory System Agents | 2009 |
NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Capsaicin; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Double-Blind Method; Erythema; Female; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain; Pain Measurement; Sensory System Agents; Treatment Outcome; Young Adult | 2008 |
Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects.
Topics: Adolescent; Adult; Alkaloids; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Drug Administration Routes; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Hypnotics and Sedatives; Injections, Intradermal; Injections, Intravenous; Male; Middle Aged; Morphine; Pain; Pain Measurement; Placebos; Pregabalin; Treatment Outcome; Young Adult | 2008 |
Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.
Topics: Analysis of Variance; Capsaicin; Female; GTP Cyclohydrolase; Humans; Male; Pain; Pain Measurement; Polymorphism, Genetic; Young Adult | 2009 |
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.
Topics: Area Under Curve; Capsaicin; Dose-Response Relationship, Drug; Female; Histamine; Humans; Incidence; Injections, Intradermal; Linear Models; Male; Mucuna; Pain; Pain Measurement; Pain Threshold; Paresthesia; Plant Structures; Pruritus; Sensation; Skin Physiological Phenomena; Time Factors | 2009 |
Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue.
Topics: Adolescent; Adult; Biological Assay; Biopsy; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Dinoprostone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Models, Biological; Models, Neurological; Nociceptors; Pain; Receptors, Opioid, mu; Sensory Receptor Cells; Sensory System Agents; Tetradecanoylphorbol Acetate; TRPV Cation Channels; Young Adult | 2009 |
Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain.
Topics: Administration, Cutaneous; Administration, Topical; Capsaicin; Capsicum; Dosage Forms; Dose-Response Relationship, Drug; Female; Half-Life; HIV Infections; HIV-1; Humans; Kinetics; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Treatment Outcome | 2009 |
Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers.
Topics: Affect; Attention; Capsaicin; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Humans; Male; Memory; Memory, Short-Term; Mental Recall; Pain; Perception; Psychomotor Performance; Reaction Time; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sensory System Agents | 2010 |
A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adult; beta-Cyclodextrins; Capsaicin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Excipients; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Sensory System Agents; Sex Factors; Single-Blind Method; Skin; Time Factors; Young Adult | 2009 |
A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate.
Topics: Adult; Capsaicin; Dermatitis, Contact; Humans; Hyperalgesia; Irritants; Male; Pain; Skin; Sodium Dodecyl Sulfate | 2010 |
Effects of intrathecal ketorolac on human experimental pain.
Topics: Adolescent; Adult; Capsaicin; Female; Hot Temperature; Humans; Injections, Spinal; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Physical Stimulation; Ultraviolet Rays; Young Adult | 2010 |
The effects of training time, sensory loss and pain on human motor learning.
Topics: Adult; Anesthetics, Local; Capsaicin; Feedback, Sensory; Female; Follow-Up Studies; Humans; Learning; Lidocaine; Male; Motor Skills; Muscle Fatigue; Pain; Reaction Time; Sensation; Sensory System Agents; Stress, Mechanical; Time Factors; Tongue; Touch; Touch Perception; Young Adult | 2010 |
Topical antacid therapy for capsaicin-induced dermal pain: a poison center telephone-directed study.
Topics: Administration, Topical; Adult; Antacids; Capsaicin; Female; Hotlines; Humans; Male; Pain; Pain Measurement; Poison Control Centers; Time Factors | 2010 |
Effects of lidocaine patch on intradermal capsaicin-induced pain: a double-blind, controlled trial.
Topics: Anesthetics, Local; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Lidocaine; Pain; Pain Measurement; Pain Threshold; Time Factors; Transdermal Patch | 2011 |
Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain.
Topics: Administration, Topical; Adult; Capsaicin; Capsicum; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Phytotherapy; Treatment Outcome | 2010 |
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Capsaicin; Cold Temperature; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Fentanyl; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Pain; Pain Measurement; Time Factors; Transdermal Patch; Young Adult | 2011 |
Effect of transdermal opioids in experimentally induced superficial, deep and hyperalgesic pain.
Topics: Administration, Cutaneous; Analgesics; Analgesics, Opioid; Buprenorphine; Capsaicin; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fentanyl; Humans; Hyperalgesia; Male; Nerve Growth Factor; Pain; Pain Measurement; Skin; Young Adult | 2011 |
Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.
Topics: Capsaicin; Carbonated Beverages; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Edema; Erythema; Humans; Injections, Intradermal; Male; Pain; Pyrazines; Sitagliptin Phosphate; Skin; Substance P; Triazoles; Vasodilation | 2011 |
Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain.
Topics: Aged; Anesthetics, Local; Capsaicin; Diabetic Neuropathies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain; Peripheral Nervous System Diseases; Polyneuropathies; Sensory System Agents; Transdermal Patch; Treatment Outcome | 2011 |
TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.
Topics: Acrolein; Administration, Intranasal; Adult; Aged; Arachidonic Acids; Biopsy; Calcium; Calcium Channels; Capsaicin; Cilia; Cross-Over Studies; Double-Blind Method; Endocannabinoids; Humans; Immunohistochemistry; Methanol; Middle Aged; Movement; Mucin 5AC; Mucin-5B; Mustard Plant; Nasal Lavage; Nasal Mucosa; Nerve Tissue Proteins; Pain; Pain Measurement; Plant Oils; Polyunsaturated Alkamides; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sensory System Agents; Sweden; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels; Young Adult | 2011 |
Lack of effect of central nervous system-active doses of nabilone on capsaicin-induced pain and hyperalgesia.
Topics: Adult; Capsaicin; Central Nervous System; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Humans; Male; Middle Aged; Pain; Pain Measurement; Treatment Outcome; Young Adult | 2012 |
The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica.
Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Minocycline; Pain; Pregabalin; Sciatica; Time Factors; Treatment Outcome | 2012 |
NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult | 2012 |
Visceral and somatic sensory function in functional dyspepsia.
Topics: Adult; Aged; Capsaicin; Double-Blind Method; Dyspepsia; Female; Foot; Hand; Humans; Irritants; Male; Middle Aged; Pain; Pain Threshold; TRPV Cation Channels; Visceral Pain; Young Adult | 2013 |
Evaluation of the analgesic efficacy and psychoactive effects of AZD1940, a novel peripherally acting cannabinoid agonist, in human capsaicin-induced pain and hyperalgesia.
Topics: Adult; Analgesics; Benzimidazoles; Cannabinoid Receptor Agonists; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Psychotropic Drugs; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonamides; Treatment Outcome; Young Adult | 2013 |
A comparative evaluation of local application of the combination of eutectic mixture of local anesthetics and capsaicin for attenuation of venipuncture pain.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Capsaicin; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Ointments; Pain; Pain Measurement; Phlebotomy; Prilocaine; Prospective Studies; Young Adult | 2013 |
Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.
Topics: Adult; Arteries; Blood Pressure; Capsaicin; Female; Humans; Hypercapnia; Injections, Intramuscular; Leg; Male; Muscle, Skeletal; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Regional Blood Flow; Sympathetic Nervous System; Tourniquets; Ultrasonography | 2002 |
Naloxone increases pain induced by topical capsaicin in healthy human volunteers.
Topics: Administration, Topical; Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Synergism; Female; Humans; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Pain; Psychophysics; Receptors, Opioid | 2002 |
Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain.
Topics: Analysis of Variance; Arm; Capsaicin; Cross-Over Studies; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Reproducibility of Results | 2002 |
The effect of chronic oral desipramine on capsaicin-induced allodynia and hyperalgesia: a double-blinded, placebo-controlled, crossover study.
Topics: Adult; Antidepressive Agents, Tricyclic; Capsaicin; Cross-Over Studies; Desipramine; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Touch | 2002 |
Dose response of intrathecal adenosine in experimental pain and allodynia.
Topics: Adenosine; Administration, Topical; Adult; Aminophylline; Analgesics, Non-Narcotic; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists | 2002 |
Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.
Topics: Acetylcholine; Adult; Bradykinin; Capsaicin; Dinoprostone; Electric Stimulation; Female; Histamine; Humans; Inflammation Mediators; Male; Microdialysis; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Peroneal Nerve; Pruritus; Psychophysics; Reflex; Sensory Thresholds; Serotonin; Skin; Sympathetic Nervous System | 2003 |
Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation.
Topics: Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Irritants; Male; Nociceptors; Pain; Prefrontal Cortex; Principal Component Analysis; Psychophysics; Regional Blood Flow; Regression Analysis; Skin; Tomography, Emission-Computed | 2003 |
Magnesium-aluminum hydroxide suspension for the treatment of dermal capsaicin exposures.
Topics: Administration, Cutaneous; Aluminum Hydroxide; Capsaicin; Double-Blind Method; Drug Combinations; Humans; Magnesium; Pain; Pain Measurement; Pilot Projects; Prospective Studies; Sodium Chloride; Suspensions; Time; Treatment Outcome | 2003 |
Gut pain and hyperalgesia induced by capsaicin: a human experimental model.
Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Ileostomy; Ileum; Intestinal Mucosa; Male; Middle Aged; Pain; Pain Measurement; Statistics, Nonparametric | 2003 |
Topical capsaicin--a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study.
Topics: Administration, Topical; Antipruritics; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; Pilot Projects; Pruritus Ani | 2003 |
A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A.
Topics: Adult; Analgesics; Botulinum Toxins, Type A; Capsaicin; Double-Blind Method; Electric Stimulation; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Pain Threshold; Placebos; Reference Values; Skin; Treatment Outcome | 2003 |
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Hot Temperature; Humans; Hydromorphone; Hyperalgesia; Lamotrigine; Pain; Pain Measurement; Piperidines; Remifentanil; Triazines | 2003 |
Effects of 1-Hz repetitive transcranial magnetic stimulation on acute pain induced by capsaicin.
Topics: Adult; Analysis of Variance; Brain Mapping; Capsaicin; Cerebrovascular Circulation; Cysteine; Electric Stimulation; Electric Stimulation Therapy; Functional Laterality; Humans; Male; Motor Cortex; Organotechnetium Compounds; Pain; Pain Management; Pain Measurement; Radiopharmaceuticals; Regional Blood Flow; Statistics as Topic; Time Factors; Tomography, Emission-Computed, Single-Photon; Transcranial Magnetic Stimulation | 2004 |
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Subcutaneous; Ketamine; Lidocaine; Male; Pain; Skin | 2004 |
Interaction between histamine-induced itch and experimental muscle pain.
Topics: Adult; Afferent Pathways; Capsaicin; Central Nervous System; Female; Histamine; Humans; Male; Models, Neurological; Muscle, Skeletal; Neural Inhibition; Nociceptors; Pain; Pruritus; Sensory Receptor Cells; Skin | 2004 |
Intravenous dextromethorphan to human volunteers: relationship between pharmacokinetics and anti-hyperalgesic effect.
Topics: Adolescent; Adult; Area Under Curve; Capsaicin; Cross-Over Studies; Dextromethorphan; Dextrorphan; Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperalgesia; Infusions, Intravenous; Male; Pain; Pain Measurement; Pain Threshold; Reaction Time; Time Factors; Treatment Outcome | 2005 |
Modulation of pain processing in hyperalgesia by cognitive demand.
Topics: Adult; Attention; Capsaicin; Cognition; Female; Hot Temperature; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Pain; Psychomotor Performance; Reaction Time | 2005 |
Lack of sex differences in modulation of experimental intraoral pain by diffuse noxious inhibitory controls (DNIC).
Topics: Adult; Analysis of Variance; Capsaicin; Cold Temperature; Conditioning, Psychological; Contraceptives, Oral; Female; Humans; Male; Neural Inhibition; Nociceptors; Pain; Pain Measurement; Pain Threshold; Reaction Time; Sex Characteristics; Time Factors | 2005 |
Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials fro
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Diclofenac; Double-Blind Method; Drug Combinations; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Infusions, Intravenous; Lasers; Male; Middle Aged; Orphenadrine; Pain | 2005 |
Effects of intradermal foot and forearm capsaicin injections in normal and vulvodynia-afflicted women.
Topics: Adult; Analysis of Variance; Area Under Curve; Blood Pressure; Candidiasis, Vulvovaginal; Capsaicin; Case-Control Studies; Cross-Over Studies; Demography; Drug Administration Routes; Female; Foot; Forearm; Heart Rate; Humans; Injections, Intradermal; Outcome Assessment, Health Care; Pain; Pain Measurement; Regional Blood Flow; Retrospective Studies; Skin; Time Factors | 2005 |
Transient cold pain has no effect on cutaneous vasodilatation induced by capsaicin: a randomized-control-crossover study in healthy subjects.
Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Cold Temperature; Cross-Over Studies; Female; Humans; Male; Pain; Regional Blood Flow; Skin; Vasodilation | 2006 |
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.
Topics: Adult; Amines; Analgesics; Analysis of Variance; Capsaicin; Central Nervous System; Cross-Over Studies; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Pain; Psychophysics | 2005 |
Secondary heat hyperalgesia detected by radiant heat stimuli in humans: evaluation of stimulus intensity and duration.
Topics: Adult; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Time Factors | 2005 |
Blink reflexes in patients with atypical odontalgia and matched healthy controls.
Topics: Adult; Aged; Analysis of Variance; Blinking; Capsaicin; Case-Control Studies; Dose-Response Relationship, Radiation; Electric Stimulation; Electromyography; Female; Functional Laterality; Humans; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Sensory Thresholds; Toothache | 2006 |
Small-fibre neuropathy in female Fabry patients: reduced allodynia and skin blood flow after topical capsaicin.
Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Case-Control Studies; Fabry Disease; Female; Humans; Laser-Doppler Flowmetry; Middle Aged; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Regional Blood Flow; Skin | 2006 |
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Method; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Humans; Hyperalgesia; Indans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 2006 |
The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Ketorolac; Male; Pain; Pain Measurement; Pain Threshold; Placebos | 2006 |
Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Capsaicin; Case-Control Studies; Double-Blind Method; Drug Administration Routes; Drug Administration Schedule; Female; Fentanyl; Humans; Hyperalgesia; Ketamine; Male; Middle Aged; Pain; Pain Measurement; Toothache | 2007 |
Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Capsaicin; Dextromethorphan; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Forearm; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Morphine; Pain; Thigh | 2007 |
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capsaicin; Cholinergic Agents; Cross-Over Studies; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Hyperalgesia; Indomethacin; Iontophoresis; Male; Neurons, Afferent; Nociceptors; Norepinephrine; Pain; Prostaglandins; Sodium Chloride; Vasodilation | 2007 |
Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia.
Topics: Aminopyridines; Analgesics; Capsaicin; Cross-Over Studies; Cyclopentanes; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Nervous System Diseases; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2008 |
Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.
Topics: Adult; Analgesics, Non-Narcotic; Botulinum Toxins, Type A; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Male; Middle Aged; Neurotoxins; Nociceptors; Pain; Pain Measurement; Pain Threshold; Placebos; Prospective Studies; Sensory Receptor Cells; Skin | 2007 |
Comparative evaluation of myolaxin and EMLA cream for attenuation of venous cannulation pain: a prospective, randomised, double blind study.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anesthetics, Local; Capsaicin; Catheterization, Peripheral; Double-Blind Method; Female; Humans; Incidence; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Pain; Pain Measurement; Prilocaine; Prospective Studies; Statistics, Nonparametric; Veins | 2007 |
An open-label pilot study of high-concentration capsaicin patch in painful HIV neuropathy.
Topics: Administration, Topical; Adult; Capsaicin; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Pain; Pilot Projects; Polyneuropathies; Sensory System Agents; Treatment Outcome | 2008 |
Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.
Topics: Adult; Analgesics, Non-Narcotic; Cannabinoids; Cannabis; Capsaicin; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Female; Humans; Hyperalgesia; Male; Marijuana Smoking; Neuropsychological Tests; Pain; Pain Measurement; Reference Values; Sensory System Agents; Sensory Thresholds; Time Factors | 2007 |
Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents; Capsaicin; Female; Humans; Inflammation; Male; Middle Aged; Mouth Diseases; Neoplasms; Pain; Pilot Projects; Radiotherapy; Time Factors; Treatment Outcome | 1995 |
Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man.
Topics: Analgesia; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Injections, Intradermal; Pain; Reference Values; Stress, Mechanical | 1995 |
A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.
Topics: Analgesics; Capsaicin; Diabetic Neuropathies; Exercise Therapy; Female; Glycated Hemoglobin; Humans; Imipramine; Male; Mexiletine; Middle Aged; Models, Neurological; Muscles; Oxazoles; Oxazolidinones; Pain; Pain Management; Pain Measurement; Piroxicam | 1993 |
Capsaicin-desensitization to the human nasal mucosa selectively reduces pain evoked by citric acid.
Topics: Administration, Intranasal; Adolescent; Adult; Analysis of Variance; Capsaicin; Citrates; Citric Acid; Female; Humans; Hydrogen-Ion Concentration; Kallidin; Male; Middle Aged; Nasal Mucosa; Pain; Saline Solution, Hypertonic | 1993 |
Topical capsaicin and burning pain.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Bone and Bones; Capsaicin; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Radionuclide Imaging | 1993 |
Effects of intravenous ketamine, alfentanil, or placebo on pain, pinprick hyperalgesia, and allodynia produced by intradermal capsaicin in human subjects.
Topics: Adult; Alfentanil; Analgesics; Anesthetics, Intravenous; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intradermal; Ketamine; Male; Midazolam; Pain; Pain Threshold; Palliative Care; Placebos; Receptors, N-Methyl-D-Aspartate; Skin | 1995 |
Intravesical capsaicin for treatment of severe bladder pain: a randomized placebo controlled study.
Topics: Administration, Intravesical; Adult; Aged; Capsaicin; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; Prospective Studies; Severity of Illness Index; Urinary Bladder Diseases | 1996 |
Influence of selective nerve fiber blocks on argon laser-induced thermal pain in the human skin.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Lasers; Male; Middle Aged; Nerve Block; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Pain; Pain Threshold; Skin | 1996 |
Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia.
Topics: Administration, Topical; Aspirin; Capsaicin; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Pain; Palliative Care; Sensation Disorders | 1996 |
The sympathetic nervous system contributes to capsaicin-evoked mechanical allodynia but not pinprick hyperalgesia in humans.
Topics: Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; Pain; Phentolamine; Placebos; Sympathetic Nervous System; Sympatholytics; Touch | 1996 |
Peripheral alpha-adrenoreceptors are involved in the development of capsaicin induced ongoing and stimulus evoked pain in humans.
Topics: Adrenergic alpha-Antagonists; Adult; Arm; Capsaicin; Female; Humans; Injections, Intradermal; Injections, Subcutaneous; Male; Middle Aged; Pain; Phentolamine; Physical Stimulation; Receptors, Adrenergic, alpha; Regional Blood Flow; Skin Temperature | 1997 |
Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans.
Topics: Adult; Alfentanil; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Capsaicin; Drug Interactions; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Reproducibility of Results | 1997 |
Effects of dextromethorphan in clinical doses on capsaicin-induced ongoing pain and mechanical hypersensitivity.
Topics: Adult; Analgesics; Capsaicin; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Humans; Hypersensitivity; Male; Middle Aged; Pain; Stress, Mechanical | 1997 |
Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography.
Topics: Adult; Brain; Capsaicin; Cerebrovascular Circulation; Humans; Injections, Subcutaneous; Male; Nerve Fibers; Pain; Tomography, Emission-Computed | 1997 |
Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Capsaicin; Cognition; Cross-Over Studies; Double-Blind Method; Drug Combinations; Excitatory Amino Acid Antagonists; Female; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intradermal; Irritants; Ketamine; Male; Pain; Psychomotor Performance; Treatment Outcome | 1998 |
Capsaicin-induced impairment of tactile spatial discrimination ability in man: indirect evidence for increased receptive fields in human nervous system.
Topics: Adult; Capsaicin; Discrimination Learning; Humans; Hyperalgesia; Male; Pain; Sensory Thresholds; Somatosensory Cortex; Touch; Vibration | 1998 |
Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicin-induced pain and hyperalgesia in normal volunteers.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Blood Pressure; Capsaicin; Clonidine; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Injections, Intravenous; Injections, Spinal; Male; Pain | 1998 |
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.
Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles | 1998 |
The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study.
Topics: Capsaicin; Double-Blind Method; Drug Therapy, Combination; Humans; Nitroglycerin; Ointments; Pain; Treatment Outcome; Vasodilator Agents; Volunteers | 1998 |
Sensory threshold changes without initial pain or alterations in cutaneous blood flow, in the area of secondary hyperalgesia caused by topical application of capsaicin in humans.
Topics: Administration, Topical; Adult; Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Laser-Doppler Flowmetry; Nerve Fibers; Pain; Physical Stimulation; Regional Blood Flow; Sensory Thresholds; Skin; Vibration | 1999 |
A new human experimental pain model: the heat/capsaicin sensitization model.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Models, Biological; Pain; Reference Values | 1999 |
Postherpetic neuralgia: role of gabapentin and other treatment modalities.
Topics: Acetates; Administration, Topical; Age Factors; Aged; Ambulatory Care; Amines; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Capsaicin; Carbamazepine; Clinical Trials as Topic; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Administration Schedule; Female; Gabapentin; gamma-Aminobutyric Acid; Herpes Zoster; Humans; Male; Middle Aged; Narcotics; Neuralgia; Pain; Risk Factors; Severity of Illness Index; Treatment Outcome | 1999 |
Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia.
Topics: Adult; Analgesics; Blood Pressure; Capsaicin; Clonidine; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Hyperalgesia; Injections, Spinal; Male; Pain | 2000 |
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain; Paresthesia; Physical Stimulation; Pruritus; Skin; Skin Physiological Phenomena; Skin Tests; Time Factors | 1999 |
Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adult; Antidepressive Agents, Tricyclic; Capsaicin; Chronic Disease; Double-Blind Method; Doxepin; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Paresthesia; Peripheral Nervous System Diseases | 2000 |
The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.
Topics: Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dizziness; Double-Blind Method; Hot Temperature; Humans; Hyperalgesia; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Male; Nociceptors; Pain; Pain Measurement; Pain Threshold; Placebos; Skin; Sleep Stages; Vision Disorders; Xerostomia | 2000 |
Capsaicin evoked pain and allodynia in post-herpetic neuralgia.
Topics: Administration, Topical; Aged; Aged, 80 and over; Capsaicin; Female; Herpes Zoster; Humans; Immunohistochemistry; Male; Middle Aged; Neuralgia; Neurons, Afferent; Nociceptors; Pain; Skin | 2000 |
Repeated local administration of noradrenaline or saline inhibits thermal hyperalgesia in pain-sensitized human skin.
Topics: Administration, Cutaneous; Adolescent; Adult; Capsaicin; Female; Humans; Hyperalgesia; Male; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Regional Blood Flow; Skin; Sodium Chloride; Vasoconstrictor Agents | 2001 |
Effect of intravenous magnesium on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Double-Blind Method; Hot Temperature; Humans; Infusions, Intravenous; Magnesium; Male; Models, Biological; Pain; Skin; Treatment Failure | 2001 |
Characterization of secondary hyperalgesia produced by topical capsaicin jelly--a new experimental tool for pain research.
Topics: Administration, Topical; Adolescent; Adult; Capsaicin; Female; Gels; Humans; Hyperalgesia; Male; Nociceptors; Pain; Reproducibility of Results | 2001 |
Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
Topics: Adenosine; Adult; Analgesics; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Spinal; Male; Middle Aged; Pain; Pain Threshold | 2002 |
The addition of glyceryltrinitrate to capsaicin cream reduces the thermal allodynia associated with the application of capsaicin alone in humans.
Topics: Capsaicin; Double-Blind Method; Drug Therapy, Combination; Humans; Nitroglycerin; Ointments; Pain; Temperature; Vasodilator Agents | 2002 |
The treatment of functional dyspepsia with red pepper.
Topics: Adult; Capsaicin; Capsicum; Double-Blind Method; Dyspepsia; Female; Humans; Male; Middle Aged; Nausea; Pain; Placebos; Severity of Illness Index; Treatment Outcome | 2002 |
Nasal effects of bradykinin and capsaicin: influence on plasma protein leakage and role of sensory neurons.
Topics: Adult; Airway Resistance; Blood Proteins; Bradykinin; Capillary Permeability; Capsaicin; Female; Humans; Male; Nasal Mucosa; Neurons, Afferent; Pain; Receptors, Bradykinin; Receptors, Neurotransmitter | 1992 |
Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands.
Topics: Administration, Topical; Capsaicin; Double-Blind Method; Female; Humans; Male; Osteoarthritis; Pain; Palliative Care | 1992 |
Adverse effects of topical capsaicin in refractory cervicobrachial pain.
Topics: Administration, Topical; Brachial Plexus Neuritis; Capsaicin; Humans; Pain | 1992 |
Analgesic effect of capsaicin in idiopathic trigeminal neuralgia.
Topics: Analgesia; Capsaicin; Female; Humans; Male; Neurons, Afferent; Pain; Psychomotor Performance; Trigeminal Neuralgia | 1992 |
Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Capsaicin Study Group.
Topics: Activities of Daily Living; Administration, Topical; Capsaicin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Leisure Activities; Locomotion; Male; Middle Aged; Pain; Sleep; Work | 1992 |
Topical 0.025% capsaicin in chronic post-herpetic neuralgia: efficacy, predictors of response and long-term course.
Topics: Administration, Cutaneous; Adult; Aged; Capsaicin; Drug Evaluation; Female; Follow-Up Studies; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia; Pain | 1991 |
Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans.
Topics: Administration, Cutaneous; Analysis of Variance; Capsaicin; Female; Hot Temperature; Humans; Male; Pain; Physical Stimulation; Sensation; Sensory Thresholds; Skin; Skin Physiological Phenomena; Time Factors; Vasodilation | 1991 |
Capsaicin: a therapeutic option for painful diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Capsaicin; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Patient Education as Topic | 1991 |
Treatment of painful diabetic neuropathy with capsaicin 0.075%.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Capsaicin; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Pain Measurement | 1991 |
Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. The Capsaicin Study Group.
Topics: Administration, Topical; Capsaicin; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Pain Measurement; Pharmaceutical Vehicles | 1991 |
Capsaicin for the treatment of pain in Guillain-Barré syndrome.
Topics: Administration, Cutaneous; Administration, Topical; Adult; Capsaicin; Female; Foot; Humans; Pain; Polyradiculoneuropathy | 1990 |
975 other study(ies) available for capsaicin and Ache
| Article | Year |
|---|---|
Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids.
Topics: Analgesics; Animals; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Pain; Pain Threshold; Rats; Transient Receptor Potential Channels | 2017 |
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.
Topics: Analgesics; Animals; Calcium Channels; Ganglia, Spinal; HEK293 Cells; Humans; Inhibitory Concentration 50; Nerve Tissue Proteins; Pain; Patch-Clamp Techniques; Rats; Resveratrol; Stilbenes; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2017 |
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neoplasm Proteins; Pain | 2022 |
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels | 2021 |
Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Gene Expression Regulation; Glutamic Acid; Hot Temperature; Humans; Male; Mice; Pain; Pyrans | 2022 |
[Involvement of TRPV1 in CNS signaling has opened up the possibility to develop TRPV1 drug therapies].
Topics: Analgesics; Capsaicin; Hot Temperature; Humans; Pain; TRPV Cation Channels | 2021 |
IL-23 Enhances C-Fiber-Mediated and Blue Light-Induced Spontaneous Pain in Female Mice.
Topics: Animals; Capsaicin; Channelrhodopsins; Disease Models, Animal; Female; Ganglia, Spinal; Humans; Interleukin-17; Interleukin-23; Light; Macrophages; Male; Mice, Inbred C57BL; Mice, Transgenic; Nerve Fibers, Unmyelinated; Nociceptors; Optogenetics; p38 Mitogen-Activated Protein Kinases; Pain; Pain Threshold; Sex Characteristics; THP-1 Cells; TRPV Cation Channels | 2021 |
Olvanil activates sensory nerve fibers, increases T cell response and decreases metastasis of breast carcinoma.
Topics: Animals; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Cell Proliferation; Female; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Nerve Fibers; Pain; Sensory Receptor Cells; TRPV Cation Channels | 2022 |
Priming of central and peripheral mechanisms with heat and cutaneous capsaicin facilitates secondary hyperalgesia to high-frequency electrical stimulation.
Topics: Capsaicin; Electric Stimulation; Hot Temperature; Humans; Hyperalgesia; Pain; Pain Threshold | 2022 |
Antinociceptive and Anti-inflammatory Effect of Corynoline in Different Nociceptive and Inflammatory Experimental Models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Berberine Alkaloids; Capsaicin; Carrageenan; Cytokines; Edema; Formaldehyde; Glutamates; Inflammation; Inflammation Mediators; Mice; Models, Theoretical; Nociception; Pain; Plant Extracts; Water | 2022 |
Slick Potassium Channels Control Pain and Itch in Distinct Populations of Sensory and Spinal Neurons in Mice.
Topics: Animals; Capsaicin; Ganglia, Spinal; Mice; Pain; Posterior Horn Cells; Potassium Channels; Pruritus; Sensory Receptor Cells; Sodium Channels; Somatostatin; Spinal Cord | 2022 |
The Isolated Mouse Jejunal Afferent Nerve Assay as a Tool to Assess the Effect of Botulinum Neurotoxins in Visceral Nociception.
Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Jejunum; Mice; Neurotoxins; Nociception; Pain | 2022 |
A Potential Route of Capsaicin to Its Binding Site in the TRPV1 Ion Channel.
Topics: Binding Sites; Capsaicin; Humans; Hydrogen Bonding; Pain; TRPV Cation Channels | 2022 |
Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.
Topics: Animals; beta-Alanine; Capsaicin; Glycols; Histamine; Hot Temperature; Humans; Mice; Nanoparticles; Pain; Pruritus | 2022 |
Emodin Reduces Inflammatory and Nociceptive Responses in Different Pain-and Inflammation-Induced Mouse Models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Emodin; Formaldehyde; Glutamates; Inflammation; Mice; Pain; Plant Extracts | 2023 |
Nociceptive signaling through transient receptor potential vanilloid 1 is regulated by Cyclin Dependent Kinase 5-mediated phosphorylation of T407 in vivo.
Topics: Animals; Capsaicin; Cyclin-Dependent Kinase 5; Ganglia, Spinal; Mice; Nociception; Pain; Phosphorylation; Threonine; TRPV Cation Channels | 2022 |
Time to consider topical capsaicin for acute trauma pain?
Topics: Administration, Topical; Capsaicin; Humans; Pain | 2022 |
Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Docosahexaenoic Acids; Hyperalgesia; Lipopolysaccharides; Mice; Monocytes; Neurons; Neutrophils; Nociceptors; Pain; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
Age-related changes in peripheral nociceptor function.
Topics: Aged; Analgesics, Opioid; Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Hyperalgesia; Nociceptors; Pain; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory Receptor Cells | 2022 |
Effects of Electroacupuncture on Gastrointestinal Motility Function, Pain, and Inflammation
Topics: Animals; Capsaicin; Electroacupuncture; Gastrointestinal Motility; Inflammation; NF-kappa B; Pain; Rats; Tumor Necrosis Factor-alpha | 2022 |
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion.
Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Male; Membrane Proteins; Mice; Nerve Growth Factor; Nociception; Pain | 2023 |
Capsaicin-induced pain increases neural responses to low-calorie non-spicy food cues: An ERP study.
Topics: Capsaicin; Cues; Evoked Potentials; Food; Humans; Pain | 2022 |
Evaluation of a polymer-coated nanoparticle cream formulation of resiniferatoxin for the treatment of painful diabetic peripheral neuropathy.
Topics: Analgesics; Animals; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diterpenes; Pain; Rats; Swine; Swine, Miniature; TRPV Cation Channels | 2023 |
Ongoing first-hand pain facilitates somatosensory resonance but inhibits affective sharing in empathy for pain.
Topics: Brain; Brain Mapping; Capsaicin; Empathy; Humans; Magnetic Resonance Imaging; Pain | 2022 |
Intrarectal Capsazepine Administration Modulates Colonic Mucosal Health in Mice.
Topics: Animals; Capsaicin; Colon; Inflammatory Bowel Diseases; Mice; Pain; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2022 |
Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis.
Topics: Animals; Capsaicin; Cartilage, Articular; Celecoxib; Dinoprostone; Humans; Mice; Mice, Knockout; Osteoarthritis; Pain | 2022 |
Identification of a Partial and Selective TRPV1 Agonist CPIPC for Alleviation of Inflammatory Pain.
Topics: Animals; Capsaicin; Ganglia, Spinal; HEK293 Cells; Humans; Mice; Molecular Docking Simulation; Pain; Sensory Receptor Cells; TRPV Cation Channels | 2022 |
Fluorescence-Based Assay for TRPV1 Channels.
Topics: Analgesics; Calcium; Capsaicin; Cations; Fluorescence; Fura-2; HEK293 Cells; Humans; Ligands; Pain; Transient Receptor Potential Channels; TRPV Cation Channels | 2023 |
Functional brain reconfiguration during sustained pain.
Topics: Brain; Brain Mapping; Capsaicin; Humans; Magnetic Resonance Imaging; Nerve Net; Neural Pathways; Pain | 2022 |
Sprayable NAHAO® hydrogel alleviates pain and accelerates rat oral mucositis wound healing.
Topics: Animals; Capsaicin; Cyclooxygenase 2; Dinoprostone; Fluorouracil; Humans; Hydrogels; Male; Matrix Metalloproteinase 9; Pain; Rats; Rats, Sprague-Dawley; Stomatitis; Wound Healing | 2023 |
The influence of kinesiophobia and pain catastrophizing on pain-induced corticomotor modulation in healthy participants: A cross sectional study.
Topics: Capsaicin; Catastrophization; Cross-Sectional Studies; Healthy Volunteers; Humans; Pain; Pain Measurement | 2022 |
Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice.
Topics: Animals; Capsaicin; Headache; Ion Channels; Mice; Pain; Pilot Projects; Stroke; Transient Receptor Potential Channels; TRPV Cation Channels | 2022 |
Sympathetic skin response as an objective tool to estimate stimulus-associated arousal in a human model of hyperalgesia.
Topics: Arousal; Capsaicin; Humans; Hyperalgesia; Pain; Pain Measurement; Skin | 2022 |
Oral cancer patients experience mechanical and chemical sensitivity at the site of the cancer.
Topics: Capsaicin; Humans; Mouth Neoplasms; Pain; Pain Measurement; Pain Threshold | 2022 |
The role of topical capsaicin gel in pain management during microfocused ultrasound treatment for neck laxity.
Topics: Anesthetics, Local; Capsaicin; Humans; Pain; Pain Management; TRPV Cation Channels; Ultrasonography | 2023 |
Role of dairy proteins in the reduction of capsaicin-induced oral burning pain.
Topics: Capsaicin; Caseins; Cross-Over Studies; Humans; Lactose; Pain | 2023 |
Nociception and pain in humans lacking a functional TRPV1 channel.
Topics: Animals; Capsaicin; Humans; Nociception; Pain; Transient Receptor Potential Channels; TRPV Cation Channels | 2023 |
A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents.
Topics: Animals; Capsaicin; Ganglia, Spinal; Humans; Mice; Pain; Pain Threshold; Rodentia; TRPV Cation Channels | 2023 |
Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin.
Topics: Capsaicin; Citrus; Fruit; Humans; Lactic Acid; Pain; Plant Extracts; Skin Diseases; TRPV Cation Channels | 2023 |
Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia.
Topics: Analgesia; Analgesics; Animals; Calcium; Capsaicin; Mice; Pain; Peptides; Transient Receptor Potential Channels; TRPV Cation Channels | 2023 |
Dihydroceramides Derived from Bacteroidetes Species Sensitize TRPV1 Channels.
Topics: Bacteroidetes; Calcium; Capsaicin; Ceramides; HEK293 Cells; Humans; Lipopolysaccharides; Pain; TRPV Cation Channels | 2023 |
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles | 2023 |
Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide.
Topics: Calcitonin Gene-Related Peptide; Capsaicin; Female; Humans; Migraine Disorders; Pain; Skin; Trigeminal Nerve | 2023 |
Striving toward hyperthermia-free analgesia: lessons from loss-of-function mutations of human TRPV1.
Topics: Analgesia; Body Temperature; Capsaicin; Fever; Humans; Mutation; Pain; TRPV Cation Channels | 2023 |
Drosophila pain sensitization and modulation unveiled by a novel pain model and analgesic drugs.
Topics: Analgesics; Animals; Capsaicin; Drosophila; Humans; Nociceptors; Pain; Sensory Receptor Cells; TRPV Cation Channels | 2023 |
Interaction of the synthetic cannabinoid WIN55212 with tramadol on nociceptive thresholds and core body temperature in a chemotherapy-induced peripheral neuropathy pain model.
Topics: Analgesics; Animals; Antineoplastic Agents; Body Temperature; Calcium; Cannabinoids; Capsaicin; Ganglia, Spinal; Male; Nociception; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Tramadol | 2023 |
Machine learning analysis predicts a person's sex based on mechanical but not thermal pain thresholds.
Topics: Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Machine Learning; Male; Pain; Pain Measurement; Pain Threshold | 2023 |
TRPV1 activation in human Langerhans cells and T cells inhibits mucosal HIV-1 infection via CGRP-dependent and independent mechanisms.
Topics: Calcitonin Gene-Related Peptide; Capsaicin; HIV Infections; Humans; Langerhans Cells; Mucous Membrane; Pain; T-Lymphocytes; TRPV Cation Channels | 2023 |
Aging exaggerates pulpal pain sensation by increasing the expression levels of nociceptive neuropeptides and inflammatory cytokines.
Topics: Aging; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 2; Cytokines; Interleukin-6; Neuropeptides; Nociception; Pain; Rats; Tumor Necrosis Factor-alpha | 2023 |
Analyzing the Antinociceptive Effect of Interleukin-31 in Mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Interleukins; Mice; Morphine; Pain | 2023 |
Molecular Links between Sensory Nerves, Inflammation, and Pain 2.0.
Topics: Afferent Pathways; Capsaicin; Humans; Inflammation; Neurons, Afferent; Pain; Peripheral Nervous System | 2023 |
Crisaborole Inhibits Itch and Pain by Preventing Neutrophil Infiltration in a Mouse Model of Atopic Dermatitis.
Topics: Animals; Calcium; Capsaicin; Chloroquine; Dermatitis, Atopic; Disease Models, Animal; Histamine; Neutrophil Infiltration; Pain; Pruritus | 2023 |
Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.
Topics: Animals; Cadaver; Calcium Radioisotopes; Capsaicin; Cattle; Cells, Cultured; Chloroquine; Dogs; Ganglia, Spinal; Histamine; Humans; Laminectomy; Molecular Imaging; Neurotransmitter Agents; Pain; Peptide Fragments; Pruritus; Radiopharmaceuticals; Sensory Receptor Cells; Serotonin; Serotonin Receptor Agonists; Substance P | 2019 |
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors.
Topics: Animals; Antipruritics; Behavior, Animal; Capsaicin; Cheek; Disease Models, Animal; Injections; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Pain; Pruritus | 2019 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
The
Topics: Animals; Arthropod Venoms; Behavior, Animal; Calcium Signaling; Capsaicin; Female; Ganglia, Spinal; Larva; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Sebaceous Glands; TRPV Cation Channels | 2019 |
Pain modulates neural responses to reward in the medial prefrontal cortex.
Topics: Brain Mapping; Capsaicin; Feedback, Psychological; Female; Humans; Linear Models; Magnetic Resonance Imaging; Male; Nerve Net; Nucleus Accumbens; Oxygen; Pain; Prefrontal Cortex; Psychophysics; Reward; Self Concept; Young Adult | 2020 |
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Nociception; Nucleus Accumbens; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological | 2020 |
Discovery of indane propanamides as potent and selective TRPV1 antagonists.
Topics: Acetamides; Amides; Analgesics; Animals; Capsaicin; Drug Design; Drug Evaluation, Preclinical; Humans; Indans; Mice; Pain; Pyridines; Structure-Activity Relationship; TRPV Cation Channels | 2020 |
Temporal aspects of endogenous pain modulation during a noxious stimulus prolonged for 1 day.
Topics: Adult; Capsaicin; Female; Humans; Pain; Pain Management; Pain Measurement; Pain Threshold | 2020 |
Abnormal Pain Sensation in Mice Lacking the Prokineticin Receptor PKR2: Interaction of PKR2 with Transient Receptor Potential TRPV1 and TRPA1.
Topics: Amphibian Proteins; Animals; Capsaicin; Ganglia, Spinal; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neuropeptides; Nociception; Pain; Plant Oils; Receptors, G-Protein-Coupled; TRPA1 Cation Channel; TRPV Cation Channels | 2020 |
Treatment of Notalgia Paresthetica with Bee Venom and Capsaicin: A Pilot Study with 20 Patients.
Topics: Adult; Bee Venoms; Capsaicin; Female; Humans; Hyperpigmentation; Male; Middle Aged; Pain; Paresthesia; Pilot Projects; Pruritus; Treatment Outcome | 2019 |
Thiopental Does Not Produce Hyperalgesia: A Laboratory Study Using Two Human Experimental Pain Models.
Topics: Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Laboratories; Pain; Thiopental | 2020 |
Trans-capsaicin for Pain Reduction and Improvement in Function in Patients With Knee Osteoarthritis: Comment on the Article by Stevens et al.
Topics: Capsaicin; Double-Blind Method; Humans; Knee Joint; Osteoarthritis, Knee; Pain | 2020 |
Reply.
Topics: Capsaicin; Double-Blind Method; Humans; Knee Joint; Osteoarthritis, Knee; Pain | 2020 |
Capsaicin-Induced Changes in Electrical Pain Perception Threshold Can Be Used to Assess the Magnitude of Secondary Hyperalgesia in Humans.
Topics: Capsaicin; Hot Temperature; Humans; Hyperalgesia; Pain; Pain Perception; Pain Threshold | 2020 |
Ethnic Differences in Experimental Pain Responses Following a Paired Verbal Suggestion With Saline Infusion: A Quasiexperimental Study.
Topics: Adult; Capsaicin; Ethnicity; Female; Humans; Male; Nocebo Effect; Pain; Pain Measurement; Pain Perception; Placebo Effect; Saline Solution; Suggestion | 2021 |
Blockage of ventrolateral periaqueductal gray matter cannabinoid 1 receptor increases dental pulp pain and pain-related subsequent learning and memory deficits in rats.
Topics: Animals; Cannabinoids; Capsaicin; Dental Pulp; Male; Memory Disorders; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Cannabinoid | 2022 |
Modality-specific facilitation of noninjurious sharp mechanical pain by topical capsaicin.
Topics: Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold | 2021 |
Capsaicin-induced pain sensitivity in short tear break-up time dry eye.
Topics: Capsaicin; Cross-Sectional Studies; Dry Eye Syndromes; Humans; Pain; Prospective Studies; Tears | 2020 |
Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anesthesia, Local; Anesthetics, Local; Animals; Calorimetry, Differential Scanning; Capsaicin; Carrageenan; Disease Models, Animal; Drug Compounding; Drug Stability; Drug Therapy, Combination; Excipients; Hyperalgesia; Inflammation; Magnetic Resonance Spectroscopy; Male; Mepivacaine; Mice; Microscopy, Electron, Scanning; Pain; Pain Management; Solubility; X-Ray Diffraction | 2020 |
Pain-autonomic interaction: A surrogate marker of central sensitization.
Topics: Biomarkers; Capsaicin; Central Nervous System Sensitization; Humans; Hyperalgesia; Pain; Pain Measurement | 2020 |
Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans.
Topics: Administration, Inhalation; Adult; Behavioral Symptoms; Brain; Capsaicin; Cough; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Neural Pathways; Pain; Reflex; Respiratory System; Sensory System Agents | 2021 |
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Male; Methylene Blue; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Receptors, N-Methyl-D-Aspartate; Ruthenium Red; Triterpenes; TRPV Cation Channels; Zebrafish; Zebrafish Proteins | 2020 |
Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage.
Topics: Anemia, Sickle Cell; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Humans; Liver Diseases; Mice; Mice, Knockout; Nociceptors; Pain; Renal Insufficiency, Chronic; Sensory Receptor Cells; TRPV Cation Channels; Vascular Diseases | 2021 |
Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment.
Topics: Animals; Capsaicin; Histamine; Mice; Pain; Pentoxifylline; Pilot Projects; Prospective Studies; Radiation-Protective Agents; Radiotherapy; Sensory System Agents; Signal Transduction; Stomatitis; Tumor Necrosis Factor-alpha | 2021 |
A neuroimaging biomarker for sustained experimental and clinical pain.
Topics: Adolescent; Adult; Aversive Agents; Biomarkers; Capsaicin; Connectome; Facial Pain; Female; Functional Neuroimaging; Humans; Low Back Pain; Magnetic Resonance Imaging; Male; Models, Neurological; Nerve Net; Pain; Pain Measurement; Predictive Value of Tests; Sensitivity and Specificity; Taste; Young Adult | 2021 |
Skin sensitivity to capsaicin, perceived stress and burn out among patients with building-related symptoms.
Topics: Administration, Topical; Adult; Capsaicin; Erythema; Ethanol; Face; Female; Hospitals, University; Humans; Male; Middle Aged; Pain; Pruritus; Sick Building Syndrome; Skin; Stress, Psychological; Surveys and Questionnaires; Sweden | 2021 |
The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
Topics: Animals; Calcium; Capsaicin; Cattle; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Histamine; Male; Mice, Inbred C57BL; Mice, Transgenic; Nerve Compression Syndromes; Neurons; Pain; Peptide Fragments; Pruritus; Receptors, G-Protein-Coupled; Receptors, Histamine H1; Receptors, Histamine H4; RNA, Messenger; TRPV Cation Channels; Up-Regulation | 2021 |
TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons.
Topics: Animals; Capsaicin; Cyclooxygenase 2; Ganglia, Spinal; Inflammation Mediators; Mice; Neurons; Pain; Transient Receptor Potential Channels; TRPV Cation Channels; Up-Regulation | 2021 |
Comparison of joint degeneration and pain in male and female mice in DMM model of osteoarthritis.
Topics: Animals; Behavior, Animal; Capsaicin; Cartilage, Articular; Disease Models, Animal; Female; Ganglia, Spinal; Male; Mice, Inbred C57BL; Microscopy, Fluorescence; Osteoarthritis; Pain; Sensory System Agents; Sex Factors; Stifle; TRPV Cation Channels | 2021 |
Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.
Topics: Animals; Biomarkers; Capsaicin; Carrageenan; Endocannabinoids; Flurbiprofen; Gene Expression Regulation; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Pain | 2021 |
TRPV1 channels as a newly identified target for vitamin D.
Topics: Capsaicin; Pain; Transient Receptor Potential Channels; TRPV Cation Channels; Vitamin D | 2021 |
Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria.
Topics: Algeria; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Behavior, Animal; Capsaicin; Edema; Formaldehyde; Histamine; Hot Temperature; Inflammation; Male; Medicine, Traditional; Mice, Inbred BALB C; Pain; Pain Measurement; Plant Extracts; Serotonin; Solutions; TRPV Cation Channels | 2021 |
Capsazepine decreases corneal pain syndrome in severe dry eye disease.
Topics: Animals; Capsaicin; Cornea; Dry Eye Syndromes; Male; Mice; Mice, Inbred C57BL; Pain; Syndrome; TRPV Cation Channels | 2021 |
CGRP release in an experimental human trigeminal pain model.
Topics: Calcitonin Gene-Related Peptide; Capsaicin; Headache Disorders; Humans; Migraine Disorders; Pain; Trigeminal Ganglion | 2021 |
Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; Pain; Piperazine; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TRPV Cation Channels; Urea | 2021 |
The Somatosensory World of the African Naked Mole-Rat.
Topics: Animals; Capsaicin; Longevity; Mole Rats; Pain | 2021 |
Sulfonamides as Selective Na
Topics: Analgesics; Animals; Capsaicin; Cell Line; Dogs; Histamine; Mice, Inbred C57BL; Molecular Docking Simulation; NAV1.7 Voltage-Gated Sodium Channel; Pain; Protein Isoforms; Pruritus; Quinolones; Rats; Structure-Activity Relationship; Sulfonamides; Voltage-Gated Sodium Channel Blockers | 2017 |
Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles.
Topics: Animals; Capsaicin; Cell Survival; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Fluorescein; Fluorescent Dyes; HEK293 Cells; Humans; Inflammation; Lactic Acid; Magnetite Nanoparticles; Male; Mice, Inbred C57BL; Pain; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Surface Properties | 2017 |
EVALUATION OF FEEDING BEHAVIOR AS AN INDICATOR OF PAIN IN SNAKES.
Topics: Animals; Boidae; Capsaicin; Feeding Behavior; Pain; Pain Measurement | 2017 |
Aversive responses by shore crabs to acetic acid but not to capsaicin.
Topics: Acetic Acid; Animals; Brachyura; Capsaicin; Male; Nociception; Pain | 2017 |
8% Capsaicin Patch as Analgesia for Severe Treprostinil Infusion Site Pain.
Topics: Aged; Antihypertensive Agents; Capsaicin; Epoprostenol; Female; Humans; Hypertension, Pulmonary; Infusions, Subcutaneous; Male; Middle Aged; Pain; Pain Management; Sensory System Agents; Severity of Illness Index; Transdermal Patch | 2017 |
Topical delivery of TRPsiRNA-loaded solid lipid nanoparticles confer reduced pain sensation via TRPV1 silencing, in rats.
Topics: Administration, Topical; Animals; Capsaicin; Female; Gene Silencing; Pain; Rats; Rats, Wistar; RNA, Small Interfering; TRPV Cation Channels | 2018 |
G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons.
Topics: Analgesics, Opioid; Animals; Baclofen; Calcium; Capsaicin; CHO Cells; Cricetulus; Electrophysiology; Female; Ganglia, Spinal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; HEK293 Cells; Humans; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Pain; Pain Measurement; Phosphatidylinositols; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; TRPM Cation Channels | 2017 |
Estradiol Sensitizes the Transient Receptor Potential Vanilloid 1 Receptor in Pain Responses.
Topics: Animals; Capsaicin; Cells, Cultured; Drug Tolerance; Estradiol; Estrus; Female; Gene Expression; Hot Temperature; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Ovariectomy; Pain; Proestrus; RNA, Messenger; Sensory Receptor Cells; Sex Characteristics; TRPV Cation Channels; Up-Regulation | 2017 |
Characterization of a novel capsaicin/heat ongoing pain model.
Topics: Adolescent; Adult; Capsaicin; Female; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Sensation; Skin; Young Adult | 2018 |
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.
Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Capsaicin; Cell Death; Cysteine; Ganglia, Spinal; HEK293 Cells; Hepatocytes; Humans; Imines; Intracellular Space; Ion Channel Gating; Male; Metabolome; Mice, Inbred C57BL; Pain; Phosphorylation; Reducing Agents; Reflex; Regional Blood Flow; Skin; TRPV Cation Channels | 2017 |
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Topics: Adrenergic Antagonists; Animals; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; Capsaicin; Cholestanols; Clathrin; Dynamins; Endocytosis; Endosomes; Formaldehyde; Freund's Adjuvant; Gene Expression Regulation; Injections, Spinal; Male; Mice; Microtomy; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nociception; Pain; Peptide Fragments; Protein Kinase C; Rats; Spinal Cord; Synaptic Transmission; Tissue Culture Techniques | 2017 |
Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross-Sectional Study.
Topics: Adolescent; Capsaicin; Cross-Sectional Studies; Female; Humans; Hyperalgesia; Male; Migraine Disorders; Oxytocin; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Sensory System Agents; Statistics, Nonparametric; Surveys and Questionnaires; Time Factors; Young Adult | 2018 |
A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.
Topics: Action Potentials; Adolescent; Adult; Aged; Animals; Calcium; Capsaicin; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Pain; Pain Insensitivity, Congenital; Pain Threshold; Point Mutation; Sensory Receptor Cells; Skin; Young Adult; Zinc Finger E-box Binding Homeobox 2 | 2018 |
Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Male; Mice; Pain; Pyrrolidines; Solubility; Structure-Activity Relationship; TRPV Cation Channels | 2018 |
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological | 2018 |
Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Ganglia, Spinal; Male; Pain; Rats; TRPV Cation Channels | 2018 |
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.
Topics: Animals; Capsaicin; Cell Line; Cell Membrane; Female; Humans; Male; Mice; Mice, Inbred C57BL; Pain; Progesterone; Protein Binding; Receptors, sigma; Sensory Receptor Cells; Sigma-1 Receptor; TRPV Cation Channels | 2018 |
Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Animals; Biopterins; Capsaicin; Cells, Cultured; Cohort Studies; Cytokines; Dystonic Disorders; Female; Fibroblasts; Genotype; GTP Cyclohydrolase; Humans; Male; Middle Aged; Mutation; Neoptera; Pain; Pain Threshold; Sex Factors; Young Adult | 2018 |
Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Dextran Sulfate; Disease Models, Animal; Disease Progression; Male; Mice, Inbred C57BL; Nerve Fibers; Pain; Substance P; TRPA1 Cation Channel; TRPV Cation Channels; Up-Regulation | 2018 |
Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.
Topics: Capsaicin; Genetic Association Studies; Genotype; High-Throughput Nucleotide Sequencing; Hot Temperature; Humans; Machine Learning; Pain; Pain Threshold; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Antinociception by the anti-oxidized phospholipid antibody E06.
Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Autoantibodies; Capsaicin; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Irritants; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Neurons; Oxidation-Reduction; Pain; Phosphatidylcholines; Rats, Wistar; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain.
Topics: Animals; Bicuculline; Capsaicin; Conditioning, Operant; GABA Antagonists; gamma-Aminobutyric Acid; K Cl- Cotransporters; Male; Neuronal Plasticity; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonergic Neurons; Serotonin Antagonists; Spinal Cord Injuries; Symporters | 2018 |
Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons.
Topics: Adult; Animals; Capsaicin; Cell Culture Techniques; Female; Ganglia, Spinal; Humans; Male; Mice; Pain; Parathyroid Hormone-Related Protein; Sensory Receptor Cells; Signal Transduction; TRPV Cation Channels; Young Adult | 2018 |
Responses of thalamic neurons to itch- and pain-producing stimuli in rats.
Topics: Action Potentials; Animals; Antipruritics; beta-Alanine; Capsaicin; Chloroquine; Histamine; Injections, Intradermal; Male; Neurons; Neurotransmitter Agents; Pain; Poisson Distribution; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Thalamic Nuclei | 2018 |
Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors.
Topics: Acrylamides; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium-Binding Proteins; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fish Venoms; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Humans; Hyperalgesia; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Neurogenic Inflammation; Oncogene Proteins v-fos; Pain; Pain Measurement; Sensory Receptor Cells; Time Factors; Touch; TRPV Cation Channels | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Effects of isopulegol in acute nociception in mice: Possible involvement of muscarinic receptors, opioid system and l-arginine/NO/cGMP pathway.
Topics: Acute Disease; Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Cyclic GMP; Cyclohexane Monoterpenes; Female; Formaldehyde; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction; Terpenes | 2018 |
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Topics: Action Potentials; Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Ion Channels; Mechanotransduction, Cellular; Mice, Knockout; Neurons; Nociception; Nociceptors; Pain | 2018 |
Vti1b promotes TRPV1 sensitization during inflammatory pain.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Humans; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pain; Qb-SNARE Proteins; RNA Interference; Sensory Receptor Cells; Signal Transduction; TRPV Cation Channels | 2019 |
Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Benzalkonium Compounds; Capsaicin; Cornea; Corneal Injuries; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Propionates; Sensory System Agents; Trigeminal Ganglion | 2019 |
Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice.
Topics: Analgesics; Animals; Calcium; Capsaicin; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Flavonoids; Inflammation; Male; Mice; Neuralgia; Pain; Pain Measurement; Spinal Cord; Synaptosomes; Toxicity Tests; TRPV Cation Channels | 2019 |
The investigation of allosteric regulation mechanism of analgesic effect using SD rat taste bud tissue biosensor.
Topics: Alginates; Allosteric Regulation; Analgesics; Animals; Arachidonic Acids; Biosensing Techniques; Body Temperature; Capsaicin; Cross-Linking Reagents; Electrochemical Techniques; Endocannabinoids; Fever; Pain; Polyunsaturated Alkamides; Rats, Sprague-Dawley; Starch; Taste Buds; TRPV Cation Channels | 2019 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Lidocaine; Male; Pain; Rats, Wistar | 2019 |
Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: An in vivo study.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Chemistry, Pharmaceutical; Drug Carriers; Edema; Emulsions; Gels; Inflammation; Male; Nanoparticles; Olive Oil; Pain; Rabbits; Rats; Rats, Wistar; Skin Absorption | 2019 |
Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons.
Topics: Animals; Calcium; Capsaicin; Diabetic Neuropathies; Disease Models, Animal; Fluoresceins; Fluorescent Dyes; Ganglia, Spinal; Gene Expression Regulation; Glucose; Ion Transport; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Optical Imaging; Pain; Patch-Clamp Techniques; Primary Cell Culture; Reactive Oxygen Species; Single-Cell Analysis; TRPV Cation Channels | 2019 |
Cutaneous nociceptive sensitization affects the directional discrimination - but not the 2-point discrimination.
Topics: Administration, Cutaneous; Adult; Antipruritics; Capsaicin; Discrimination, Psychological; Female; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Touch | 2019 |
Trigeminal Pain Responses in Obese ob/ob Mice Are Modality-Specific.
Topics: Animals; Behavior; Capsaicin; Diet; Eating; Hyperalgesia; Leptin; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Models, Animal; Nociception; Obesity; Pain; Pain Measurement; Quinine; Trigeminal Ganglion; TRPV Cation Channels | 2019 |
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Topics: Animals; Behavior, Animal; Biopterins; Biosynthetic Pathways; Capsaicin; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Disease Models, Animal; Dystonic Disorders; Formaldehyde; Freund's Adjuvant; GTP Cyclohydrolase; Hot Temperature; Inflammation; Inheritance Patterns; Mice; Mice, Inbred C57BL; Motor Activity; Nociception; Pain; Phenylketonurias; Physical Stimulation; Rats; Stress, Mechanical | 2013 |
The TGR5 receptor mediates bile acid-induced itch and analgesia.
Topics: Action Potentials; Animals; Bile Acids and Salts; Capsaicin; Cells, Cultured; Cholestasis; Dermis; Enkephalin, Leucine; Female; Ganglia, Spinal; Gastrin-Releasing Peptide; Gene Expression; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Opioid Peptides; Organ Specificity; Pain; Pain Perception; Patch-Clamp Techniques; Pruritus; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Single-Cell Analysis; Spinal Cord | 2013 |
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular Structure; Olea; Pain; Pain Measurement; Pregabalin; Rotarod Performance Test; Time Factors; Triterpenes | 2013 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarates; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Rats; Rats, Sprague-Dawley | 2013 |
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation; Male; Naloxone; Nociception; Oxidopamine; Pain; Rats; Rats, Sprague-Dawley; Restraint, Physical; Sciatic Nerve; Stress, Psychological; Sympathetic Nervous System | 2013 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histamine; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofibromatosis 1; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Pain Threshold; Pruritus | 2013 |
Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons.
Topics: Adenosine Triphosphate; Animals; Burns; Capsaicin; Cells, Cultured; Dermatitis; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neurons; Pain; Pinus; Plant Oils; Resins, Plant; Skin | 2014 |
Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Caesalpinia; Capsaicin; Ethanol; Female; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Phytotherapy; Plant Bark; Plant Extracts; Solvents | 2013 |
Healthy volunteers can be phenotyped using cutaneous sensitization pain models.
Topics: Antipruritics; Burns; Capsaicin; Healthy Volunteers; Hot Temperature; Humans; Hyperalgesia; Models, Biological; Pain; Pain Measurement; Reproducibility of Results; Skin | 2013 |
Pain modality- and sex-specific effects of COMT genetic functional variants.
Topics: Adolescent; Adult; Animals; Capsaicin; Catechol O-Methyltransferase; Cohort Studies; Disease Models, Animal; Female; Genotype; Humans; Male; Mice; Mice, Inbred Strains; Middle Aged; Pain; Pain Threshold; Polymorphism, Single Nucleotide; Sensory System Agents; Sex Characteristics; Species Specificity; Young Adult | 2013 |
"Chemical-pain sensor" based on nanovesicle-carbon nanotube hybrid structures.
Topics: Animals; Biosensing Techniques; Capsaicin; Cloning, Molecular; Diterpenes; HEK293 Cells; Hot Temperature; Humans; Immobilized Proteins; Limit of Detection; Nanostructures; Nanotubes, Carbon; Pain; Rats; Sensitivity and Specificity; Sensory System Agents; TRPV Cation Channels | 2013 |
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cytokines; Disease Models, Animal; Freund's Adjuvant; Glycosides; Hyperalgesia; Inflammation; Male; Mice; Molecular Structure; Oxidative Stress; Pain; Plant Extracts; TRPV Cation Channels | 2013 |
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Catheterization; Hyperalgesia; Immunohistochemistry; Male; Medulla Oblongata; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Synaptic Transmission | 2013 |
Role of adenosine receptors in the anti-nociceptive effects of allopurinol in mice.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Hot Temperature; Male; Mice; Motor Activity; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Receptor, Adenosine A2A; Receptors, Purinergic P1 | 2013 |
Facilitation of pain in the human spinal cord by nocebo treatment.
Topics: Adult; Capsaicin; Female; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Oxygen; Pain; Pain Measurement; Pain Perception; Pain Threshold; Spinal Cord; Surveys and Questionnaires; Time Factors; Young Adult | 2013 |
Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.
Topics: Animals; Animals, Newborn; Capsaicin; Cell Count; Chloroquine; Embryo, Mammalian; Ganglia, Spinal; Gastrin-Releasing Peptide; Gene Expression Regulation, Developmental; Homeodomain Proteins; Mice; Mice, Transgenic; Muscle Proteins; Neurons; Oligopeptides; Pain; Physical Stimulation; Protein Kinase C; Protein Precursors; Pruritus; Psychomotor Performance; Sensation; Somatostatin; Tachykinins; Vesicular Glutamate Transport Protein 1 | 2013 |
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperature; Hyperalgesia; Ligation; Male; Mice; Pain; Phytotherapy; Plant Extracts; Sciatic Nerve; Solvents; Touch | 2013 |
Expectation requires treatment to boost pain relief: an fMRI study.
Topics: Adult; Anesthetics, Local; Antipruritics; Brain; Capsaicin; Female; Humans; Image Processing, Computer-Assisted; Lidocaine; Male; Motivation; Oxygen; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Prilocaine; Skin; Time Factors; Young Adult | 2014 |
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Polymers; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Time Factors | 2014 |
[Descending modulation of cardiac nociception by the rostral ventromedial medulla in rats].
Topics: Animals; Capsaicin; Electric Stimulation; Electromyography; Male; Medulla Oblongata; Nociception; Nociceptors; Pain; Pericardium; Rats; Rats, Sprague-Dawley; Sensory System Agents | 2013 |
Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior.
Topics: Afferent Pathways; Animals; Anti-Dyskinesia Agents; Botulinum Toxins; Botulinum Toxins, Type A; Capsaicin; Functional Laterality; Gene Expression Regulation; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Muscle Strength; Nociceptors; Pain; Pain Threshold; Posterior Horn Cells; Receptors, Neurokinin-1; Spinal Cord; Substance P; Time Factors | 2014 |
Polypeptide modulators of TRPV1 produce analgesia without hyperthermia.
Topics: Analgesia; Analgesics; Animals; Body Temperature; Capsaicin; Cell Line; Disease Models, Animal; Fever; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Male; Mice; Pain; Peptides; TRPV Cation Channels | 2013 |
Antioxidant and orofacial anti-nociceptive activities of the stem bark aqueous extract of Anadenanthera colubrina (Velloso) Brenan (Fabaceae).
Topics: Amidines; Analgesics; Animals; Antioxidants; Biphenyl Compounds; Capsaicin; Colubrina; Fabaceae; Glutamic Acid; Lipid Peroxidation; Male; Mice; Pain; Pain Measurement; Phytotherapy; Picrates; Plant Bark; Plant Extracts; Plant Stems | 2014 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; Formaldehyde; Glutamic Acid; Histamine; Inflammation; Male; Mice; Naloxone; Pain; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats, Wistar; Sterculia | 2014 |
Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Disease Models, Animal; Edema; Flavonoids; Formaldehyde; Male; Mice; Molecular Structure; Pain; Pain Measurement; Piper | 2014 |
Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; KATP Channels; Male; Mice; Motor Activity; Narcotic Antagonists; Neurotransmitter Agents; ortho-Aminobenzoates; Pain; Pain Perception; Pain Threshold; Potassium Channel Blockers; Reaction Time; Time Factors | 2014 |
Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Action Potentials; Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociception; Pain; Protons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; TRPV Cation Channels | 2014 |
Involvement of multiple µ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission.
Topics: Analgesics; Animals; Capsaicin; Male; Mice; N-Methylaspartate; Nociception; Oligopeptides; Pain; Presynaptic Terminals; Receptors, Opioid, mu; Somatostatin; Substance P; Synaptic Transmission | 2014 |
Spinal 5-HT₅A receptors mediate 5-HT-induced antinociception in several pain models in rats.
Topics: Acetic Acid; Animals; Capsaicin; Female; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord | 2014 |
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamine; Hyperalgesia; Injections, Intradermal; Mice; Mice, Inbred C57BL; Pain; Posterior Horn Cells; Pruritus; Sensory System Agents; Spinal Cord | 2014 |
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Indoles; Mice; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship | 2014 |
Regional and seasonal differences in skin irritation and neurosensitivity in Chinese and South Korean women.
Topics: Adult; Capsaicin; China; Dermatitis, Contact; Female; Healthy Volunteers; Humans; Lactic Acid; Pain; Patch Tests; Republic of Korea; Seasons; Sensory System Agents; Skin Irritancy Tests; Sodium Dodecyl Sulfate; Surface-Active Agents; Vitamin A; Vitamins; Young Adult | 2015 |
The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain.
Topics: Action Potentials; Adipokines; Animals; Capsaicin; Chemokines; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Freund's Adjuvant; In Vitro Techniques; Inflammation; Intercellular Signaling Peptides and Proteins; Male; Nerve Fibers, Unmyelinated; Neurons; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Spinal Cord | 2014 |
Analgesic efficacy and safety of DALDA peptide analog delivery to the brain using oil-in-water nanoemulsion formulation.
Topics: Analgesics; Animals; Brain; Capsaicin; Disease Models, Animal; Drug Carriers; Emulsions; Magnetic Resonance Imaging; Male; Mice, Inbred Strains; Nanostructures; Oligopeptides; Pain; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2014 |
Botulinum toxin type A selectivity for certain types of pain is associated with capsaicin-sensitive neurons.
Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Male; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sensory Receptor Cells; Synaptosomal-Associated Protein 25; Trigeminal Ganglion; TRPV Cation Channels | 2014 |
Somatostatin 4 receptor activation modulates TRPV1[correction of TPRV1] currents in dorsal root ganglion neurons.
Topics: Animals; Butanes; Calcium; Capsaicin; Cells, Cultured; Freund's Adjuvant; Ganglia, Spinal; Inflammation; Male; Naphthalenes; Neurons; Nociception; Pain; Pertussis Toxin; Rats; Receptors, Somatostatin; Sulfones; TRPV Cation Channels | 2014 |
Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats.
Topics: Animals; Blotting, Western; Capsaicin; Male; Morpholines; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Trigeminal Nuclei | 2014 |
Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats.
Topics: Afferent Pathways; Animals; Capsaicin; Cornea; Fluorescent Antibody Technique; Immunohistochemistry; Male; Microscopy, Confocal; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus; TRPV Cation Channels | 2014 |
A spinal analog of memory reconsolidation enables reversal of hyperalgesia.
Topics: Animals; Anisomycin; Capsaicin; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Male; Memory; Mice; Mice, Inbred C57BL; Pain; Posterior Horn Cells; Protein Synthesis Inhibitors; Sensory System Agents; Spinal Cord | 2014 |
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517
Topics: Aminopyridines; Analgesics; Animals; Body Temperature; Calcium; Capsaicin; CHO Cells; Cricetulus; Freund's Adjuvant; Ganglia, Spinal; Humans; Hydrogen-Ion Concentration; Male; Pain; Rats, Sprague-Dawley; Sensory Receptor Cells; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels | 2014 |
Z944: a first in class T-type calcium channel modulator for the treatment of pain.
Topics: Acetamides; Administration, Oral; Benzamides; Calcium Channel Blockers; Capsaicin; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Humans; Lasers; Male; Pain; Piperidines; Time Factors | 2014 |
Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels.
Topics: Adenosine Triphosphate; Animals; Capsaicin; Cell Membrane; Cells, Cultured; Cyclophosphamide; Cystitis; Female; Nerve Growth Factor; Pain; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats, Sprague-Dawley; Receptor, trkA; TRPV Cation Channels; Urothelium | 2015 |
Painful diabetic neuropathy: many similarly effective therapies with widely dissimilar costs.
Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Capsaicin; Diabetic Neuropathies; Humans; Pain; Selective Serotonin Reuptake Inhibitors | 2014 |
Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.
Topics: Animals; Capsaicin; Consciousness; Grooming; Hyperalgesia; Isothiocyanates; Male; Mouth Mucosa; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Stimulation, Chemical; Time Factors | 2015 |
Inflammatory pain models with capsaicin or glutamate injections: are they comparable and reproducible?
Topics: Capsaicin; Glutamic Acid; Humans; Inflammation; Pain; Reproducibility of Results | 2014 |
No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals.
Topics: Adult; Capsaicin; Ethanol; Female; Gene-Environment Interaction; Genotype; Healthy Volunteers; Hot Temperature; Humans; Male; Pain; Pain Management; Pain Threshold; Polymorphism, Genetic; Receptor, Serotonin, 5-HT1A; Temperature; Young Adult | 2014 |
Analgesic effects of botulinum neurotoxin type A in a model of allyl isothiocyanate- and capsaicin-induced pain in mice.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Capsaicin; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Pain | 2015 |
Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit.
Topics: Animals; Base Sequence; Capsaicin; Cells, Cultured; Ganglia, Spinal; Gene Expression Profiling; Male; Nociceptors; Pain; Paracrine Communication; Phosphatidylinositols; Potassium Channels; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Sequence Analysis, DNA; TRPV Cation Channels | 2014 |
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.
Topics: Action Potentials; Animals; Biophysical Phenomena; Capsaicin; Cells, Cultured; CHO Cells; Cricetulus; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pain; Pain Measurement; Physical Stimulation; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2015 |
Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Bone and Bones; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Dopamine Agonists; Drug Discovery; Female; Glutamic Acid; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Pain; Signal Transduction; Small Molecule Libraries | 2015 |
Cold and L-menthol-induced sensitization in healthy volunteers--a cold hypersensitivity analogue to the heat/capsaicin model.
Topics: Administration, Topical; Adult; Capsaicin; Cold Temperature; Female; Hand; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Male; Menthol; Pain; Pain Measurement; Pain Threshold; Skin; Skin Temperature; Time Factors | 2015 |
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides; Capsaicin; Carbamates; Cinnamates; Disease Models, Animal; Endocannabinoids; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Interleukin-6; Lumbar Vertebrae; Male; Osteoarthritis; Pain; Pain Management; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; TRPV Cation Channels | 2015 |
Distinct neural representations of placebo and nocebo effects.
Topics: Adult; Anesthetics, Local; Capsaicin; Cerebral Cortex; Female; Hot Temperature; Humans; Lidocaine; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System; Nocebo Effect; Pain; Pain Perception; Periaqueductal Gray; Placebo Effect; Reward; Set, Psychology; Young Adult | 2015 |
Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.
Topics: Animals; Calcium; Capsaicin; Cell Culture Techniques; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Inflammation; Male; Membrane Potentials; Neurons; Pain; Pain Threshold; Patch-Clamp Techniques; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2015 |
Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons.
Topics: Animals; Anoctamin-1; Behavior, Animal; Capsaicin; Chloride Channels; Excitatory Postsynaptic Potentials; Ganglia, Spinal; HEK293 Cells; Humans; Mice, Inbred C57BL; Models, Biological; Pain; Presynaptic Terminals; Protein Binding; Sensory Receptor Cells; TRPV Cation Channels | 2015 |
Effectiveness of High-Frequency Electrical Stimulation Following Sensitization With Capsaicin.
Topics: Adult; Biophysical Phenomena; Capsaicin; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Reaction Time; Sensory System Agents; Time Factors; Transcutaneous Electric Nerve Stimulation; Young Adult | 2015 |
Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.
Topics: Action Potentials; Animals; Antipruritics; Calcium; Capsaicin; Ganglia, Spinal; Mice, Knockout; Mice, Transgenic; Neurons; Pain | 2015 |
HDAC4 is required for inflammation-associated thermal hypersensitivity.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Capsaicin; Down-Regulation; Freund's Adjuvant; Histone Deacetylases; Hyperalgesia; Hypersensitivity; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Protein Precursors; Sensory Receptor Cells; Transcription, Genetic; TRPV Cation Channels | 2015 |
Capsaicin-sensitive C- and A-fibre nociceptors control long-term potentiation-like pain amplification in humans.
Topics: Adult; Biophysics; Capsaicin; Electric Stimulation; Healthy Volunteers; Humans; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers; Neural Conduction; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Sensory System Agents; Skin; TRPV Cation Channels; Young Adult | 2015 |
Novel therapeutics in the field of capsaicin and pain.
Topics: Analgesics; Capsaicin; Humans; Pain | 2015 |
Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model.
Topics: Administration, Cutaneous; Adolescent; Adult; Animals; Antibodies, Monoclonal; Biomarkers; Calcitonin Gene-Related Peptide; Capsaicin; Double-Blind Method; Humans; Laser-Doppler Flowmetry; Macaca fascicularis; Male; Middle Aged; Pain; Regional Blood Flow; Young Adult | 2015 |
[The pain resource nurse in a cancer unit].
Topics: Administration, Cutaneous; Anesthesia, Spinal; Capsaicin; Health Resources; Hospice and Palliative Care Nursing; Humans; Injections, Spinal; Neoplasms; Oncology Service, Hospital; Pain; Pain Management | 2015 |
Role of TRPV1 channels of the dorsal periaqueductal gray in the modulation of nociception and open elevated plus maze-induced antinociception in mice.
Topics: Animals; Anxiety; Capsaicin; Fear; Male; Maze Learning; Mice; Nociception; Pain; Pain Measurement; Periaqueductal Gray; TRPV Cation Channels | 2015 |
Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.
Topics: Analgesics; Animals; Calcium; Capsaicin; Cell Line; Fever; HEK293 Cells; Humans; Pain; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Peptide; Triazines; TRPV Cation Channels | 2015 |
TRPV1 channel inhibition contributes to the antinociceptive effects of Croton macrostachyus extract in mice.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Croton; Mice; Pain; Plant Extracts; TRPV Cation Channels | 2015 |
Translating synaptic plasticity into sensation.
Topics: Capsaicin; Humans; Long-Term Potentiation; Male; Nerve Fibers; Nociceptors; Pain; Sensory System Agents | 2015 |
Characterizing pinprick-evoked brain potentials before and after experimentally induced secondary hyperalgesia.
Topics: Adult; Capsaicin; Cerebral Cortex; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Nociception; Pain; Pain Measurement; Physical Stimulation; Young Adult | 2015 |
Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists.
Topics: Administration, Oral; Amides; Analgesics; Animals; Body Temperature; Capsaicin; Humans; Inhibitory Concentration 50; Mice; Pain; Protein Binding; Structure-Activity Relationship; Temperature; TRPV Cation Channels | 2016 |
Pirt contributes to uterine contraction-induced pain in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Carrier Proteins; Female; Ganglia, Spinal; Gene Expression Regulation; Membrane Proteins; Mice, Inbred C57BL; Nerve Fibers; Pain; Uterine Contraction; Uterus | 2015 |
Abnormal trigeminal sensory processing in obese mice.
Topics: Animals; Behavior, Animal; Capsaicin; Mice; Mice, Obese; Neurons; Obesity; Pain; Sensation; Sensation Disorders; Sensory Receptor Cells; Trigeminal Ganglion | 2016 |
Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.
Topics: Analgesia; Animals; Astrocytes; Capsaicin; Down-Regulation; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Locus Coeruleus; Male; Neurons; Norepinephrine; Pain; Pain Threshold; Rats, Sprague-Dawley; RNA, Small Interfering; Spinal Cord | 2015 |
Selective Activation of Nociceptor TRPV1 Channel and Reversal of Inflammatory Pain in Mice by a Novel Coumarin Derivative Muralatin L from Murraya alata.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; Capsaicin; Coumarins; Ganglia, Spinal; HEK293 Cells; Humans; Inflammation; Ion Channel Gating; Magnetic Resonance Spectroscopy; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Murraya; Neurons; Nociceptors; Pain; Rats; TRPV Cation Channels | 2016 |
Peripheral sensitization reduces laser-evoked potential habituation.
Topics: Capsaicin; Central Nervous System; Electroencephalography; Evoked Potentials; Female; Habituation, Psychophysiologic; Hand; Humans; Hyperalgesia; Lasers; Male; Pain; Peripheral Nerves; Reaction Time; Reference Standards; Sensation; Young Adult | 2015 |
Biological activity of a polypeptide modulator of TRPV1 receptor.
Topics: Analgesics; Animals; Body Temperature; Capsaicin; Motor Activity; Pain; Peptides; Protein Binding; Sea Anemones; TRPV Cation Channels | 2015 |
Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels.
Topics: Acrylamides; Animals; Calcium; Capsaicin; Cells, Cultured; Cricetinae; Hydrogen-Ion Concentration; Pain; TRPV Cation Channels | 2016 |
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B | 2016 |
Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Body Temperature; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Diamines; Drug Design; Gene Expression; Humans; Ibuprofen; Male; Mice; Nociception; Pain; Piperazines; Recombinant Proteins; Sheep; Structure-Activity Relationship; TRPV Cation Channels | 2016 |
Variability in Capsaicin-stimulated Calcitonin Gene-related Peptide Release from Human Dental Pulp.
Topics: Adolescent; Adult; Aged; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Humans; Male; Middle Aged; Molar; Nociceptors; Pain; Tooth Fractures; TRPV Cation Channels; Young Adult | 2016 |
Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling.
Topics: Acetic Acid; Acid Sensing Ion Channels; Acidosis; Animals; Capsaicin; Ganglia, Spinal; Male; Methoxyhydroxyphenylglycol; Neurons; Pain; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium Channel Blockers; Tetrodotoxin; TRPV Cation Channels | 2016 |
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Capsaicin; Disease Models, Animal; Electric Stimulation; Hyperalgesia; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; Magnetic Resonance Imaging; Nociception; Osteoarthritis, Knee; Pain; Rats, Sprague-Dawley | 2016 |
[Assessment of the Effect of Pain on Autonomic Nervous System in Human Body Using Heart Rate Variability Analysis].
Topics: Autonomic Nervous System; Capsaicin; Electrocardiography; Feasibility Studies; Healthy Volunteers; Heart Rate; Humans; Pain; Pain Measurement | 2015 |
Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways.
Topics: Adult; Afferent Pathways; Brain; Capsaicin; Central Nervous System Sensitization; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Hyperalgesia; Male; Nociceptors; Pain; Pain Measurement; Reaction Time; ROC Curve; Signal-To-Noise Ratio; Skin; Young Adult | 2016 |
Enhanced itch elicited by capsaicin in a chronic itch model.
Topics: Acetone; Animals; Behavior, Animal; Capsaicin; Chronic Disease; Disease Models, Animal; Ether; Female; Injections, Subcutaneous; Male; Mice, Inbred C57BL; Neurons; Pain; Pruritus; Trigeminal Ganglion; TRPV Cation Channels; Water | 2016 |
Nociceptin/orphanin FQ receptor expression in clinical pain disorders and functional effects in cultured neurons.
Topics: Animals; Brachial Plexus Neuropathies; Calcium; Calcium Ionophores; Capsaicin; Cells, Cultured; Cystitis, Interstitial; Female; Ganglia, Spinal; Gene Expression Regulation; Humans; Ionomycin; Male; Neuroma; Neurons; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Peripherins; Rats; Rats, Wistar; Receptors, Opioid; TRPV Cation Channels; Urinary Bladder, Overactive | 2016 |
Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Capsaicin; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Larva; Lethal Dose 50; Male; Methanol; Mice; Motor Activity; Pain; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Rosales; Rotarod Performance Test; Solvents; Water | 2016 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaicin; Clodronic Acid; Etidronic Acid; Excitatory Amino Acid Agonists; Foscarnet; Glutamic Acid; Lumbar Vertebrae; Mice; Mice, Inbred BALB C; N-Methylaspartate; Pain; Sodium-Phosphate Cotransporter Proteins; Spinal Cord; Substance P | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels | 2016 |
Impaired diffuse noxious inhibitory controls in specific alternation of rhythm in temperature-stressed rats.
Topics: Animals; Capsaicin; Diffuse Noxious Inhibitory Control; Heat-Shock Response; Hyperalgesia; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley | 2016 |
The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na(+) currents.
Topics: Analgesics; Animals; Capsaicin; Fabaceae; Formaldehyde; Ganglia, Spinal; Hot Temperature; Lectins; Male; Mice; Neurons; Nociception; Pain; Physical Stimulation; Rats, Wistar; Seeds; Sodium Channels | 2016 |
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Edema; Hyperalgesia; Knee Joint; Male; Mice, Inbred C57BL; Mice, Knockout; Neurogenic Inflammation; Pain; Protein Precursors; Receptor, PAR-2; Receptors, Neurokinin-1; Substance P; Tachykinins; Touch; TRPV Cation Channels; Tryptases | 2016 |
Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates.
Topics: Animals; Capsaicin; Cerebellum; Female; Frontal Lobe; Gyrus Cinguli; Hot Temperature; Humans; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis; Magnetic Resonance Imaging; Male; Pain; Somatosensory Cortex; Tail; Thermosensing | 2016 |
Competitive inhibition of TRPV1-calmodulin interaction by vanilloids.
Topics: Binding Sites; Calmodulin; Capsaicin; Diterpenes; Humans; Pain; Protein Binding; Protein Conformation; Protein Interaction Maps; Sensory Receptor Cells; TRPV Cation Channels | 2016 |
Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.
Topics: Acetanilides; Analgesics; Animals; Anti-Inflammatory Agents; Calcium Signaling; Capsaicin; HEK293 Cells; Humans; Inflammation; Mice; Mice, Knockout; Mustard Plant; Oximes; Pain; Plant Oils; Purines; TRPA1 Cation Channel | 2016 |
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25 | 2016 |
Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey.
Topics: Animals; Anxiety; Behavior, Animal; Capsaicin; Depression; Diterpenes; Genotype; Inflammation; Male; Pain; Periaqueductal Gray; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; RNA, Messenger; TRPV Cation Channels | 2016 |
The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel.
Topics: Alkaloids; Animals; Anthelmintics; Antibiotics, Antineoplastic; Capsaicin; Cells, Cultured; Cesium; Chlorides; Enzyme Inhibitors; Freund's Adjuvant; Ganglia, Spinal; Gene Expression; Guanidines; HEK293 Cells; HSC70 Heat-Shock Proteins; Humans; Inflammation; Matrines; Mice; Neurons; Pain; Potassium Channel Blockers; Quinolizines; Rats; TRPV Cation Channels | 2016 |
Ephedra Herb extract activates/desensitizes transient receptor potential vanilloid 1 and reduces capsaicin-induced pain.
Topics: Animals; Anti-Inflammatory Agents; Capsaicin; Ephedra; Humans; Male; Mice; Pain; Pain Measurement; Transfection; TRPV Cation Channels | 2017 |
Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch.
Topics: Amino Acid Sequence; Animals; Binding Sites; Capsaicin; HEK293 Cells; Humans; Ion Channel Gating; Mice, Inbred C57BL; Molecular Docking Simulation; Oleic Acid; Pain; Pruritus; Rats; TRPV Cation Channels | 2016 |
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Mice; Mice, Knockout; Microfilament Proteins; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neuralgia; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Sensory System Agents; Spinal Cord; TRPV Cation Channels | 2016 |
Manipulating the extracellular matrix: an animal model of the bladder pain syndrome.
Topics: Animals; Capsaicin; Chondroitin ABC Lyase; Disease Models, Animal; Extracellular Matrix; Female; Glucuronidase; Glycosylation; Neutrophil Infiltration; Pain; Proteoglycans; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord; Urinary Bladder; Urinary Bladder Diseases | 2017 |
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers.
Topics: Administration, Oral; Adult; Analgesics; Capsaicin; Cross-Over Studies; Dermatitis, Contact; Electroencephalography; Evoked Potentials, Somatosensory; Female; Healthy Volunteers; Humans; Hyperalgesia; Lasers; Male; Middle Aged; Pain; Pain Measurement; Placebos; Single-Blind Method; Skin; Treatment Outcome; Ultraviolet Rays; Young Adult | 2017 |
Antinociceptive and Antihyperalgesic Activity of a Traditional Maya Herbal Preparation Composed of Pouteria Campechiana, Chrysophyllum Cainito, Citrus Limonum, and Annona Muricata.
Topics: Alloxan; Analgesics; Animals; Annona; Capsaicin; Citrus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Pain; Plant Extracts; Pouteria; Rats | 2017 |
Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography.
Topics: Adult; Brain Mapping; Capsaicin; Electroencephalography; Evoked Potentials, Motor; Female; Humans; Male; Motor Cortex; Pain; Transcranial Magnetic Stimulation; Young Adult | 2017 |
Catecholamines reduce transient receptor potential vanilloid type 1 desensitization in cultured dorsal root ganglia neurons.
Topics: Adrenergic Antagonists; Animals; Calcium; Capsaicin; Catecholamines; Cells, Cultured; Epinephrine; Ganglia, Spinal; Inflammation; Male; Neurons; Norepinephrine; Pain; Rats; Rats, Wistar; Receptors, Adrenergic; Skin; TRPV Cation Channels | 2016 |
Noradrenergic inhibition of presynaptic TRPV1 channels: a new pathway of pain control.
Topics: Capsaicin; Humans; Norepinephrine; Pain; TRPV Cation Channels | 2017 |
Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
Topics: Acetic Acid; Animals; Capsaicin; Corticosterone; Cues; Disease Models, Animal; Formaldehyde; Male; Mice; Naloxone; Narcotic Antagonists; Nociception; Pain; Receptors, Opioid; Recognition, Psychology; Social Behavior; Stress, Psychological; Visual Perception | 2017 |
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Compounds, 3-Ring; Hyperalgesia; Ketoprofen; Mice; Nociception; Pain; Pyrimidines; Spiro Compounds | 2017 |
Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats.
Topics: Animals; Antipruritics; Capsaicin; Consciousness; Female; Hyperalgesia; Nerve Fibers; Neurotransmitter Agents; Nociceptors; Pain; Peptides; Rats, Wistar; Sciatic Nerve; Sensory Receptor Cells; Somatostatin | 2017 |
The role of the paratrigeminal nucleus in the pressor response to sciatic nerve stimulation in the rat.
Topics: Afferent Pathways; Animals; Blood Pressure; Capsaicin; Denervation; Electric Stimulation; Excitatory Postsynaptic Potentials; Functional Laterality; Inflammation Mediators; Male; Medulla Oblongata; Neural Inhibition; Nociceptors; Pain; Presynaptic Terminals; Rats; Rats, Wistar; Reflex; Sciatic Nerve; Synaptic Transmission; Trigeminal Nucleus, Spinal; Vasoconstriction | 2008 |
Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats.
Topics: Animals; Capsaicin; Chronic Disease; Electric Stimulation; Evoked Potentials; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Male; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; TRPV Cation Channels | 2008 |
Area 3a neuron response to skin nociceptor afferent drive.
Topics: Adenosine Triphosphate; Anesthesia, Local; Animals; Capsaicin; Electrophysiology; Female; Foot; Hand; Hot Temperature; Male; Neurons, Afferent; Nociceptors; Pain; Parietal Lobe; Physical Stimulation; Saimiri; Skin; Somatosensory Cortex | 2009 |
Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat.
Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Inflammation Mediators; Injections, Intralesional; Lumbar Vertebrae; Male; Pain; Pain Measurement; Probability; Prostatitis; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Spinal Cord | 2008 |
Separate peripheral pathways for pruritus in man.
Topics: Capsaicin; Electric Stimulation; Electrophysiology; Histamine; Hot Temperature; Humans; Mechanoreceptors; Mucuna; Nerve Fibers, Unmyelinated; Neural Pathways; Neurons, Afferent; Pain; Peripheral Nerves; Physical Stimulation; Pruritus; Psychophysics; Skin; Stimulation, Chemical | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; GABA Agents; Glutamic Acid; Hot Temperature; Male; Mice; Motor Activity; Nitric Oxide Synthase; Pain; Pain Measurement; Pain Threshold; Quercetin; Reaction Time; Serotonin Antagonists; Signal Transduction | 2008 |
Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1).
Topics: Analgesics; Animals; Aprotinin; Base Sequence; Capsaicin; Cats; Cnidarian Venoms; Dose-Response Relationship, Drug; Humans; Male; Mice; Molecular Sequence Data; Oocytes; Pain; Peptides; Protein Folding; Sea Anemones; Sensory System Agents; Structural Homology, Protein; TRPV Cation Channels; Xenopus laevis | 2008 |
Antinociceptive effect of the Polygala sabulosa hydroalcoholic extract in mice: evidence for the involvement of glutamatergic receptors and cytokine pathways.
Topics: Administration, Oral; Analgesics; Animals; Capsaicin; Cytokines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Interleukin-1beta; Male; Mice; Pain; Pain Measurement; Plant Extracts; Polygala; Receptors, Glutamate; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Functional depletion of capsaicin-sensitive primary afferent fibers attenuates rat pain-related behaviors and paw edema induced by the venom of scorpion Buthus martensi Karch.
Topics: Animals; Capsaicin; Diterpenes; Edema; Hindlimb; Hyperalgesia; Immunohistochemistry; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Spinal Cord | 2008 |
Attenuation of naloxone-induced Vc pERK hyper-expression following capsaicin stimulation of the face in aged rat.
Topics: Aging; Animals; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Face; Naloxone; Narcotic Antagonists; Neural Pathways; Pain; Phosphorylation; Rats; Rats, Inbred F344; Sensory System Agents; Trigeminal Caudal Nucleus | 2008 |
Topical agents in the treatment of rheumatic pain.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Clinical Trials as Topic; Humans; Irritants; Pain; Rheumatic Diseases; Sensory System Agents | 2008 |
Residual spinothalamic tract pathways predict development of central pain after spinal cord injury.
Topics: Adult; Capsaicin; Cold Temperature; Female; Histamine; Hot Temperature; Humans; Male; Menthol; Middle Aged; Nerve Fibers; Neuralgia; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Prognosis; Sensation; Spinal Cord Injuries; Spinothalamic Tracts | 2008 |
Spinal mechanisms of antinociceptive effect caused by oral administration of bis-selenide in mice.
Topics: Administration, Oral; Analgesics; Animals; Capsaicin; Cytokines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Injections, Spinal; Mice; Molecular Structure; Nociceptors; Organoselenium Compounds; Pain; Pain Threshold; Potassium Channel Blockers; Potassium Channels; Reaction Time; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Spinal Cord | 2008 |
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
Topics: Analysis of Variance; Animals; Blotting, Western; Capsaicin; Cell Line; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; G-Protein-Coupled Receptor Kinases; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Pain Threshold; Peroxidase; Proto-Oncogene Proteins c-fos; Visceral Afferents | 2009 |
Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related Peptide driven by dorsal root reflexes.
Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Freund's Adjuvant; Immunohistochemistry; Injections, Intra-Arterial; Male; Neurons; Nociceptors; Pain; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rhizotomy; Sensory System Agents; Spinal Nerve Roots; TRPV Cation Channels; Vasodilator Agents | 2008 |
Cold hyposensitivity after topical application of capsaicin in humans.
Topics: Administration, Topical; Adult; Afferent Pathways; Capsaicin; Cold Temperature; Female; Hot Temperature; Humans; Male; Pain; Perception; Reaction Time; Reference Values; Sensation; Sensory Thresholds; Skin Temperature; Thermosensing; TRPV Cation Channels; Young Adult | 2008 |
Adrenergic regulation of P2X3 and TRPV1 receptors: differential effects of spared nerve injury.
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Capsaicin; Hindlimb; Male; Norepinephrine; Pain; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Purinergic P2; Receptors, Purinergic P2X3; TRPV Cation Channels | 2008 |
Behavioral differentiation between itch and pain in mouse.
Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Forelimb; Hindlimb; Histamine; Male; Mice; Pain; Pruritus | 2008 |
A BOLD-fMRI study of cerebral activation induced by injection of algesic chemical substances into the anesthetized rat forepaw.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Forelimb; Formaldehyde; Isoflurane; Magnetic Resonance Imaging; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Specific Pathogen-Free Organisms; Stimulation, Chemical | 2008 |
Luminal hydrogen sulfide plays a pronociceptive role in mouse colon.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Colon; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hydrogen Sulfide; Immunohistochemistry; Male; Mibefradil; Mice; Nociceptors; Pain; Patch-Clamp Techniques; Phosphorylation; Sulfides | 2009 |
Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve.
Topics: Anesthetics, Local; Animals; Capsaicin; Drug Therapy, Combination; Male; Nerve Block; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2008 |
Neurofibromatosis: the role of guanosine triphosphatase activating proteins in sensory neuron function.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Mice; Mutation; Neurofibromatosis 1; Neurofibromin 1; Nociceptors; Pain; Patch-Clamp Techniques; Signal Transduction | 2008 |
Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons.
Topics: Animals; Capsaicin; Carcinogens; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; Genetic Vectors; Humans; Nociceptors; Pain; Patch-Clamp Techniques; Phorbol Esters; Phosphorylation; Protein Kinase C-epsilon; Rats; Sensory Receptor Cells; Sensory System Agents; TRPV Cation Channels | 2008 |
Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Tumor; Dose-Response Relationship, Drug; Galanin; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Morphine; Narcotics; Nerve Fibers, Unmyelinated; Neuroblastoma; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Reaction Time; Receptor, Cannabinoid, CB1; Rimonabant; Stimulation, Chemical; Sulfonamides; TRPV Cation Channels | 2008 |
Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humans.
Topics: Adult; Analysis of Variance; Brain; Brain Mapping; Brain Stem; Capsaicin; Cross-Over Studies; Female; Humans; Image Processing, Computer-Assisted; Injections, Intradermal; Magnetic Resonance Imaging; Male; Oxygen; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Psychophysics; Skin | 2008 |
Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Extracellular Signal-Regulated MAP Kinases; Hot Temperature; Male; Nociceptors; Pain; Phosphorylation; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Signal Transduction; Thermosensing; Trigeminal Caudal Nucleus | 2008 |
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
Topics: Amino Acids; Animals; Capsaicin; Colforsin; Electrophysiological Phenomena; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Nociceptors; Pain; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; TRPV Cation Channels; Xanthenes | 2009 |
Taste, olfactory and trigeminal neophobia in rats with forebrain lesions.
Topics: Amygdala; Animals; Avoidance Learning; Capsaicin; Cerebral Cortex; Denervation; Disease Models, Animal; Male; Neuropsychological Tests; Pain; Pentanols; Phobic Disorders; Physical Stimulation; Prosencephalon; Rats; Rats, Sprague-Dawley; Saccharin; Smell; Taste | 2009 |
Inhibition of swallowing reflex following phosphorylation of extracellular signal-regulated kinase in nucleus tractus solitarii neurons in rats with masseter muscle nociception.
Topics: Animals; Capsaicin; Deglutition; Deglutition Disorders; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Male; Masseter Muscle; Mastication; Neural Inhibition; Neural Pathways; Neurons; Nociceptors; Pain; Phosphorylation; Rats; Rats, Sprague-Dawley; Reflex; Solitary Nucleus; Up-Regulation | 2009 |
Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors.
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Capsaicin; Female; Formaldehyde; Hydrogen-Ion Concentration; Inflammation; Nerve Tissue Proteins; Pain; Rats; Rats, Wistar; Serotonin; Sodium Channels | 2009 |
The response of plasma catecholamines in rats simultaneously exposed to immobilization and painful stimuli.
Topics: Animals; Capsaicin; Epinephrine; Male; Norepinephrine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Physiological; Stress, Psychological | 2008 |
Persistent pain is dependent on spinal mitochondrial antioxidant levels.
Topics: Analysis of Variance; Animals; Antioxidants; Capsaicin; Ditiocarb; Dose-Response Relationship, Drug; Foot; Free Radical Scavengers; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Knockout; Mitochondria; Pain; Pain Measurement; Pain Threshold; Reactive Oxygen Species; Spinal Cord; Stilbamidines; Superoxide Dismutase | 2009 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
Topics: Adult; Analysis of Variance; Capsaicin; Drug Interactions; Glutamic Acid; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tendons; Young Adult | 2009 |
Algesic agents exciting muscle nociceptors.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Capsaicin; Glutamic Acid; Hydrogen-Ion Concentration; Interleukins; Muscles; Nerve Growth Factor; Nociceptors; Pain; Potassium Chloride; Prostaglandins; Protons; Rats; Serotonin; Sodium Chloride | 2009 |
Involvement of capsaicin-sensitive afferents and the Transient Receptor Potential Vanilloid 1 Receptor in xylene-induced nocifensive behaviour and inflammation in the mouse.
Topics: Afferent Pathways; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurogenic Inflammation; Nociceptors; Pain; Pain Measurement; Pain Threshold; Presynaptic Terminals; Sensory Receptor Cells; Sensory System Agents; TRPV Cation Channels; Xylenes | 2009 |
Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn.
Topics: Animals; Calcium Channels; Capsaicin; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Miniature Postsynaptic Potentials; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinothalamic Tracts; Statistics, Nonparametric; Synaptic Transmission; TRPV Cation Channels | 2009 |
Explicit episodic memory for sensory-discriminative components of capsaicin-induced pain: immediate and delayed ratings.
Topics: Adaptation, Physiological; Capsaicin; Discrimination, Psychological; Humans; Male; Memory, Short-Term; Pain; Pain Threshold; Sensory System Agents; Young Adult | 2009 |
Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.
Topics: Alfentanil; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Central Nervous System Agents; Dose-Response Relationship, Drug; Female; Hot Temperature; Imidazoles; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Pain; Piperidines; Pruritus; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement, Psychology; Respiratory Insufficiency; Spiro Compounds | 2009 |
Independent psychophysical measurement of experimental modulations in the somatotopy of cutaneous heat-pain stimuli.
Topics: Adult; Brain Mapping; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Lasers; Male; Neuropsychological Tests; Nociceptors; Pain; Perception; Physical Stimulation; Psychophysics; Sensory System Agents; Somatosensory Cortex; Young Adult | 2009 |
Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.
Topics: Action Potentials; Anilides; Animals; Arachidonic Acids; Calcium Channel Blockers; Capsaicin; Cinnamates; Dose-Response Relationship, Drug; Endocannabinoids; Hindlimb; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Skin; Tibial Nerve; TRPV Cation Channels | 2009 |
Possible role for TRPV1 in neomycin-induced inhibition of visceral hypersensitivity in rat.
Topics: Animals; Capsaicin; Colon; Dilatation; Feces; Female; Humans; Neomycin; Pain; Pregnancy; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans; Sensory System Agents; TRPV Cation Channels; Visceral Afferents | 2009 |
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium | 2009 |
Experimental forearm immobilization in humans reduces capsaicin-induced pain and flare.
Topics: Adolescent; Adult; Area Under Curve; Capsaicin; Female; Forearm; Hand; Humans; Immobilization; Male; Pain; Pain Measurement; Regional Blood Flow; Skin; Skin Physiological Phenomena; Skin Temperature; Substance P; Time Factors; Young Adult | 2009 |
Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord.
Topics: Analgesics; Animals; Baclofen; Capsaicin; Drug Interactions; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Narcotic Antagonists; Neural Inhibition; Pain; Pain Threshold; Peptides; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Opioid, mu; Sensory System Agents; Spinal Cord; Synapses; Synaptic Transmission | 2009 |
Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Molecular Structure; Pain; Phytotherapy; Plants, Medicinal; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA; Receptors, Neurotransmitter; Receptors, Tachykinin; Triterpenes | 2009 |
Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia.
Topics: Adult; Analysis of Variance; Attention; Capsaicin; Female; Humans; Hyperalgesia; Male; Neuropsychological Tests; Pain; Pain Measurement; Perception; Photic Stimulation; Physical Stimulation; Sensory System Agents; Task Performance and Analysis; Young Adult | 2009 |
Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1'-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine].
Topics: Analgesics; Animals; Capsaicin; Chromatography, High Pressure Liquid; Humans; Ligands; Mice; Microsomes, Liver; Pain; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor | 2009 |
Differentiating thermal allodynia and hyperalgesia using dynamic hot and cold plate in rodents.
Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Cold Temperature; Dimethyl Sulfoxide; Escape Reaction; Hindlimb; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Nocifensive behaviors components evoked by brief laser pulses are mediated by C fibers.
Topics: Anesthesia; Animals; Behavior, Animal; Capsaicin; Cerebral Cortex; Electrodes, Implanted; Electroencephalography; Electromyography; Electrophysiology; Evoked Potentials; Lasers, Gas; Male; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 2009 |
PGE(2)-induced lasting nociception to heat: evidences for a selective involvement of A-delta fibres in the hyperpathic component of hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Dimethyl Sulfoxide; Dinoprostone; Hot Temperature; Hyperalgesia; Indomethacin; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar | 2010 |
Role of RVM neurons in capsaicin-evoked visceral nociception and referred hyperalgesia.
Topics: Abdomen; Animals; Behavior, Animal; Blood Pressure; Capsaicin; Colon; Electrophysiology; Hyperalgesia; Male; Medulla Oblongata; Microelectrodes; Microinjections; Neurons; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
How pain becomes itch.
Topics: Capsaicin; Humans; Pain; Pruritus | 2009 |
Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Femoral Fractures; Male; Nerve Fibers; Neurofilament Proteins; Pain; Periosteum; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells | 2009 |
Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments.
Topics: Animals; Antibodies; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Glycopeptides; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Neprilysin; Pain; Pain Measurement; Peptide Fragments; Protease Inhibitors; Spinal Cord; Substance P | 2009 |
Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.
Topics: Allyl Compounds; Animals; Ankyrins; Brain-Derived Neurotrophic Factor; Calcium Channels; Capsaicin; Cells, Cultured; Cold Temperature; Ganglia, Spinal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Hot Temperature; Humans; Isocyanates; Pain; Rats; Rats, Wistar; Sensory System Agents; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels; TRPV Cation Channels | 2009 |
Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons.
Topics: Acids; Acrolein; Animals; Biological Products; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Helleborus; Hot Temperature; Membrane Potentials; Pain; Patch-Clamp Techniques; Rats; Sensory Receptor Cells; TRPV Cation Channels | 2010 |
Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus.
Topics: Adult; Analysis of Variance; Body Temperature; Capsaicin; Cerebral Cortex; Electric Stimulation; Electroencephalography; Esophagus; Evoked Potentials, Somatosensory; Female; Humans; Hydrochloric Acid; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Rectum | 2010 |
Antinociceptive activity of a new benzofuranone derived from a chalcone.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalcone; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Linear Models; Male; Mice; Nociception; Pain; Pain Measurement | 2009 |
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Male; Mice; Motor Activity; Neurons; Oleanolic Acid; Opioid Peptides; Pain; Pain Measurement; Physical Stimulation; Protein Kinase C; Psychomotor Performance; Rats; Rats, Wistar; Serotonin; Signal Transduction; TRPV Cation Channels | 2009 |
Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Dipeptides; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Migraine Disorders; Neurons; Pain; Piperazines; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Wistar; Trigeminal Nucleus, Spinal | 2009 |
Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.
Topics: Animals; Apoptosis; Capsaicin; Female; Heart; Ischemic Preconditioning; KATP Channels; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Pain; Protein Kinase C; Signal Transduction | 2009 |
Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia.
Topics: Analgesia; Animals; Capsaicin; Diterpenes; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; TRPV Cation Channels | 2009 |
17Beta-estradiol mediates the sex difference in capsaicin-induced nociception in rats.
Topics: Animals; Behavior, Animal; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Female; Injections, Intradermal; Male; Ovariectomy; Pain; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sex Characteristics | 2009 |
Of pungency, pain, and naked mole rats: chili peppers revisited.
Topics: Animals; Bolivia; Capsaicin; Capsicum; Ecosystem; Fusarium; Mole Rats; Mycoses; Nociceptors; Pain; Polymorphism, Genetic; Seeds; TRPV Cation Channels | 2009 |
Electrophysiological characterization of the rat trigeminal caudalis (Vc) neurons following intramuscular injection of capsaicin.
Topics: Animals; Capsaicin; Evoked Potentials; Excitatory Amino Acid Antagonists; Injections, Intramuscular; Male; Masseter Muscle; Microelectrodes; Neurons; Pain; Physical Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Sensory System Agents; Trigeminal Caudal Nucleus | 2010 |
Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.
Topics: Acetanilides; Action Potentials; Animals; Capsaicin; Formaldehyde; Ganglia, Spinal; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; Purines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2009 |
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation.
Topics: Analgesics; Animals; Capsaicin; Diterpenes; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Pain Measurement; Plant Oils; Sensory System Agents; Stress, Mechanical; Thermosensing; Trigeminal Nerve; TRPV Cation Channels | 2010 |
Behavioral and urological evaluation of a testicular pain model.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Indomethacin; Male; Nerve Fibers, Unmyelinated; Neurons, Afferent; Pain; Prostatitis; Rats; Rats, Wistar; Testis; Urinary Bladder; Urinary Bladder, Overactive | 2010 |
Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Neurons; Neuropeptides; Pain; Pain Measurement; Piperidines; Receptor, Parathyroid Hormone, Type 2; Reflex; Sciatica; Signal Transduction; Time Factors; TRPV Cation Channels | 2010 |
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.
Topics: Animals; Capsaicin; Central Nervous System Agents; Freund's Adjuvant; Hot Temperature; Male; Medulla Oblongata; Mustard Plant; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 2010 |
Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification.
Topics: Amino Acid Sequence; Animals; Calcium; Capsaicin; Cell Line; Cysteine; Humans; Hydrogen Peroxide; Molecular Sequence Data; Oxidants; Oxidative Stress; Pain; Patch-Clamp Techniques; Rats; Sequence Alignment; TRPV Cation Channels | 2009 |
Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors.
Topics: Anesthesia; Animals; Capsaicin; Cold Temperature; Freund's Adjuvant; Hindlimb; Hot Temperature; Male; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Reflex; Skin; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels | 2010 |
Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons.
Topics: Action Potentials; Animals; Aquaporin 1; Bradykinin; Capsaicin; Cell Line, Tumor; Dinoprostone; Ganglia, Spinal; Gene Expression Regulation; Inflammation; Mice; Mice, Knockout; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Oxytocics; Pain; Pain Management; Perception; Sensory System Agents; Sodium Channels; Vasodilator Agents | 2010 |
Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation.
Topics: Adult; Asian People; Black or African American; Capsaicin; Female; Hispanic or Latino; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Neurogenic Inflammation; Pain; Pain Measurement; Pain Threshold; Pruritus; Regional Blood Flow; Sensory Thresholds; Skin; White People; Young Adult | 2010 |
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Topics: Animals; Capsaicin; Electric Stimulation; GABA-B Receptor Antagonists; Injections, Spinal; Male; Morpholines; Neurons; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; Substance P; TRPV Cation Channels | 2010 |
The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Caulerpa; Dose-Response Relationship, Drug; Edema; Female; Formaldehyde; Indole Alkaloids; Indoles; Male; Mice; Pain; Peritonitis; Seaweed | 2009 |
Role of attentional focus on bodily sensations in sensitivity to itch and pain.
Topics: Administration, Topical; Adult; Attention; Capsaicin; Cold Temperature; Electric Stimulation; Female; Histamine; Humans; Iontophoresis; Middle Aged; Pain; Pain Measurement; Pain Threshold; Perception; Personality; Physical Stimulation; Pruritus; Sensory Thresholds; Surveys and Questionnaires; Young Adult | 2010 |
Receptor changes in brain tissue of rats treated as neonates with capsaicin.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Brain; Cannabinoid Receptor Modulators; Capsaicin; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Male; Nerve Net; Pain; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Serotonin; Sensory Deprivation; Sensory Receptor Cells; Sensory System Agents; Serotonin; TRPV Cation Channels; Up-Regulation | 2010 |
A new combination cream for the treatment of severe neuropathic pain.
Topics: Administration, Topical; Analgesics; Capsaicin; Diabetic Neuropathies; Drug Combinations; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Ointments; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin | 2010 |
Catastrophizing delays the analgesic effect of distraction.
Topics: Adult; Analgesia; Anxiety; Attention; Behavior Therapy; Capsaicin; Female; Humans; Male; Neuropsychological Tests; Pain; Pain Management; Pain Measurement; Reaction Time; Self-Assessment; Sensory System Agents; Stress, Psychological; Time Factors; Young Adult | 2010 |
Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin.
Topics: Administration, Cutaneous; Animals; Botulinum Toxins, Type A; Capsaicin; Dermatitis; Disease Models, Animal; Drug Delivery Systems; Electric Stimulation; Exocytosis; Hindlimb; Inflammation Mediators; Male; Neurogenic Inflammation; Nociceptors; Pain; Peptides; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Treatment Outcome | 2010 |
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) during capsaicin-induced pain: modulatory effects on motor cortex excitability.
Topics: Adult; Analysis of Variance; Capsaicin; Electromyography; Evoked Potentials, Motor; Female; Functional Laterality; Hand; Humans; Male; Motor Cortex; Muscle, Skeletal; Neural Inhibition; Pain; Pain Management; Prefrontal Cortex; Pyramidal Tracts; Time Factors; Transcranial Magnetic Stimulation | 2010 |
Selectively targeting pain in the trigeminal system.
Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Capsaicin; Electric Stimulation; Lidocaine; Mice; Mice, Knockout; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reflex; Trigeminal Ganglion; TRPV Cation Channels | 2010 |
Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Extracellular Signal-Regulated MAP Kinases; Neurons; Pain; Phosphorylation; Presynaptic Terminals; Protein Subunits; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Neurokinin-1; Spinal Cord; Synapses; Vesicular Glutamate Transport Protein 2 | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethanol; Female; Formaldehyde; Glutamic Acid; Locomotion; Male; Mice; Morphine; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Zanthoxylum | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
Human experimental pain models 3: heat/capsaicin sensitization and intradermal capsaicin models.
Topics: Alfentanil; Analgesics, Opioid; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Ketamine; Pain; Pain Measurement; Sensory System Agents; Skin | 2010 |
Ion channels in analgesia research.
Topics: Analgesia; Analgesics; Capsaicin; Cell Line; Humans; Ion Channels; Nociceptors; Pain; Patch-Clamp Techniques; Protein Isoforms; Sensory System Agents; TRPV Cation Channels | 2010 |
Spinal levels of nonprotein thiols are related to nociception in mice.
Topics: Acetylcysteine; Acute Disease; Analgesics; Animals; Antimetabolites; Arthritis, Experimental; Behavior, Animal; Buthionine Sulfoximine; Capsaicin; Disease Models, Animal; Female; Foot Injuries; Lipid Peroxidation; Lumbar Vertebrae; Male; Mice; Oxidative Stress; Pain; Spinal Cord; Sulfhydryl Compounds | 2010 |
LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation.
Topics: Administration, Oral; Analgesics; Animals; Capsaicin; Female; Hydrazines; Mice; Pain; Rats; Rats, Wistar; Sciatic Nerve; TRPV Cation Channels; Xenopus laevis | 2010 |
Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain.
Topics: Animals; Capsaicin; Glutamic Acid; Inflammation; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate | 2010 |
Changes in situation-specific pain catastrophizing precede changes in pain report during capsaicin pain: a cross-lagged panel analysis among healthy, pain-free participants.
Topics: Adult; Capsaicin; Catastrophization; Data Interpretation, Statistical; Female; Humans; Male; Pain; Pain Measurement; Positron-Emission Tomography; Regression Analysis; Stress, Psychological; Surveys and Questionnaires | 2010 |
Low intensity intra-epidermal electrical stimulation can activate Aδ-nociceptors selectively.
Topics: Administration, Cutaneous; Adult; Capsaicin; Electric Stimulation; Electrophysiology; Evoked Potentials; Female; Humans; Male; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Reaction Time; Sensory System Agents | 2010 |
Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate.
Topics: Animals; Bone and Bones; Capsaicin; Disease Models, Animal; Hindlimb; Humans; Injections, Intra-Articular; Iodoacetates; Nociceptors; Osteoarthritis; Pain; Patella; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Weight-Bearing | 2010 |
Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic pain.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Capsaicin; Female; HIV Infections; Humans; Male; Middle Aged; Neuralgia, Postherpetic; Pain; Peripheral Nervous System Diseases; Treatment Outcome; Young Adult | 2010 |
Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity.
Topics: Action Potentials; Alkaloids; Animals; Benzodioxoles; Capsaicin; Diterpenes; Ganglia, Spinal; Kinetics; Lipid Metabolism; Male; Neurons, Afferent; Pain; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sensory Receptor Cells; Solubility; TRPV Cation Channels; Urea | 2010 |
Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Capsaicin; Endorphins; Endothelium, Vascular; Flow Cytometry; Freund's Adjuvant; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Male; Nerve Fibers; Oxidopamine; Pain; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar; Sensory Receptor Cells; Sympathetic Nervous System; Sympatholytics; Tyrosine 3-Monooxygenase | 2010 |
Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Topics: Action Potentials; Acyclic Monoterpenes; Aldehydes; Analgesics; Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamates; Male; Mice; Monoterpenes; Morphine; Motor Activity; Narcotics; Neural Conduction; Nociceptors; Pain; Rats; Rats, Wistar; Sciatic Nerve; Sensory System Agents | 2010 |
Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice.
Topics: Analgesics, Opioid; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; TRPV Cation Channels | 2010 |
Luminal serotonin time-dependently modulates vagal afferent driven antinociception in response to colorectal distention in rats.
Topics: Afferent Pathways; Analgesics; Animals; Capsaicin; Colon; Dilatation, Pathologic; Food Hypersensitivity; Granisetron; Hyperalgesia; Intestinal Mucosa; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Time Factors; Vagotomy; Vagus Nerve | 2011 |
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Sensory Receptor Cells; Spinal Cord | 2010 |
Evidence for the involvement of μ-opioid and δ-opioid receptors in the antinociceptive effect caused by oral administration of m-trifluoromethyl-diphenyl diselenide in mice.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavioral Research; Capsaicin; Mice; Organosilicon Compounds; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensory System Agents | 2010 |
Phenotypes and peripheral mechanisms underlying inflammatory pain-related behaviors induced by BmK I, a modulator of sodium channels.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bupivacaine; Capsaicin; Ganglia, Spinal; Indomethacin; Inflammation; Male; Morphine; Neurons; Pain; Pain Measurement; Patch-Clamp Techniques; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Sodium Channel Blockers | 2010 |
Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice.
Topics: Analgesics; Animals; Capsaicin; Chalcones; Flavonoids; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Models, Chemical; Motor Activity; Pain; Pain Measurement; Plant Extracts; Reaction Time; Receptors, Opioid | 2010 |
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
Topics: Animals; Capsaicin; Colon; Fenclonine; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Male; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin; TRPV Cation Channels; Viscera | 2010 |
Synthesis and preliminary biological evaluation of capsaicin derivatives as potential analgesic drugs.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cell Line; Disease Models, Animal; Drug Design; Edema; Female; Humans; Male; Mice; Molecular Structure; Pain; Rats; Stereoisomerism; TRPV Cation Channels; Xylenes | 2010 |
Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol.
Topics: Analgesics; Animals; Antioxidants; Capsaicin; Cymenes; Drug Evaluation; Formaldehyde; Male; Mice; Monoterpenes; Pain; Pain Measurement; Plant Extracts; Reaction Time | 2010 |
The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice.
Topics: Acute Disease; Animals; Benzamidines; Capsaicin; Ceruletide; Disease Models, Animal; Gene Expression Regulation; Guanidines; Hyperalgesia; Male; Mice; Oligopeptides; Pain; Pancreatitis; Proto-Oncogene Proteins c-fos; Receptor, PAR-2; Spinal Cord; TRPV Cation Channels | 2010 |
Laser modulation of heat and capsaicin receptor TRPV1 leads to thermal antinociception.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Signaling; Capsaicin; Dinoprostone; HEK293 Cells; HeLa Cells; Hot Temperature; Humans; Lasers, Solid-State; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Neurons; Nociceptors; Pain; Pain Threshold; Reaction Time; Ruthenium Red; Sensory System Agents; Sensory Thresholds; Thermosensing; Touch; Trigeminal Nerve; TRPV Cation Channels | 2010 |
Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat.
Topics: Analgesia; Analgesics; Analysis of Variance; Animals; Capsaicin; Male; Nerve Net; Pain; Rats; Rats, Sprague-Dawley | 2010 |
An update on new pain medications.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Drug Delivery Systems; Humans; Pain | 2010 |
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
Topics: Acute Disease; Animals; Capsaicin; Cell Count; Chronic Disease; Glutamic Acid; Immunohistochemistry; Mice; Mice, Knockout; Mice, Transgenic; Mutation; NAV1.8 Voltage-Gated Sodium Channel; Neural Pathways; Neurons; Nociceptors; Pain; Patch-Clamp Techniques; Pruritus; Receptors, Bombesin; Sodium Channels; Spinal Cord; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2010 |
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Injections, Intradermal; Irritants; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Mucuna; Naltrexone; Narcotic Antagonists; Pain; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Thrombin; Time Factors | 2010 |
Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity.
Topics: Analgesics; Animals; Antioxidants; Capsaicin; Flavanones; Flavonoids; Hyperalgesia; Mice; Pain; Rats; TRPV Cation Channels | 2011 |
Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect.
Topics: Analgesics; Animals; Benzamides; Capsaicin; Fever; HEK293 Cells; Humans; Male; Neuralgia; Pain; Pain Measurement; Protein Binding; Quinolones; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2011 |
Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; Gout; Hesperidin; Ketorolac; Male; Pain; Rats | 2011 |
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Fixatives; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Mice; Mice, Knockout; Nociceptors; Pain; Sensory System Agents; Vesicular Glutamate Transport Protein 2 | 2010 |
Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats.
Topics: Acetic Acid; Acupuncture Points; Afferent Pathways; Analgesia; Animals; Capsaicin; Disease Models, Animal; Electroacupuncture; Female; Gene Expression Regulation; Male; Muscle, Skeletal; Nerve Fibers; Pain; Pain Management; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Snake Venoms; Solitary Nucleus; Trigeminal Nuclei; Viscera | 2011 |
Cutaneous limb inflammation produces analgesia to pressure pain in the ipsilateral forehead of healthy volunteers.
Topics: Adolescent; Adult; Analgesia; Capsaicin; Complex Regional Pain Syndromes; Female; Forearm; Forehead; Functional Laterality; Humans; Hyperalgesia; Inflammation; Irritants; Pain; Pain Perception; Pain Threshold; Pressure; Skin; Young Adult | 2011 |
N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity.
Topics: Administration, Topical; Analgesics; Animals; Arachidonic Acids; Calcium; Capsaicin; Cell Line; Endocannabinoids; Eye; Humans; Male; Mice; Pain; Polyunsaturated Alkamides; TRPV Cation Channels | 2011 |
[Simultaneously determination of atropine sulphate, diphenhydramine hydrochloride, capsaicin and dihydrocapsaicin in pain-relieving plaster for arthritis by RP-HPLC].
Topics: Arthritis; Atropine; Capsaicin; Chromatography, High Pressure Liquid; Diphenhydramine; Drugs, Chinese Herbal; Humans; Pain | 2010 |
Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat.
Topics: Animals; Calcitonin; Calcium; Calcium Channels; Capsaicin; Ganglia, Spinal; Humans; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Wistar; Signal Transduction | 2011 |
Modulation of pain perception by transcranial magnetic stimulation of left prefrontal cortex.
Topics: Adult; Capsaicin; Female; Functional Laterality; Humans; Male; Middle Aged; Neural Inhibition; Pain; Pain Management; Pain Measurement; Prefrontal Cortex; Transcranial Magnetic Stimulation | 2011 |
Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Capsaicin; Dopamine; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Male; Medulla Oblongata; Microinjections; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Posterior Horn Cells; Protein Kinase C; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spinal Cord; Sulpiride | 2011 |
Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.
Topics: Aminoquinolines; Anilides; Animals; Arachidonic Acids; Blotting, Western; Calcium; Capsaicin; Cells, Cultured; Cinnamates; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Endocannabinoids; Ganglia, Spinal; Humans; Imidazoles; Mice; Microscopy, Confocal; Neurons; Pain; Poly I-C; Polyunsaturated Alkamides; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Toll-Like Receptor 3; Toll-Like Receptor 7; Toll-Like Receptor 9; Toll-Like Receptors; TRPV Cation Channels | 2011 |
Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Electric Stimulation; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Potassium; ras GTPase-Activating Proteins; Sensory Receptor Cells; Sensory System Agents; TRPV Cation Channels | 2011 |
Neonatal tissue damage facilitates nociceptive synaptic input to the developing superficial dorsal horn via NGF-dependent mechanisms.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Escherichia coli Proteins; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Transgenic; Nerve Growth Factor; Pain; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sex Factors; Signal Transduction; Spinal Cord | 2011 |
A novel human volunteer pain model using contact heat evoked potentials (CHEP) following topical skin application of transient receptor potential agonists capsaicin, menthol and cinnamaldehyde.
Topics: Acrolein; Adult; Capsaicin; Electroencephalography; Evoked Potentials; Female; Hot Temperature; Human Experimentation; Humans; Male; Menthol; Middle Aged; Models, Biological; Pain; Pain Measurement; Pain Threshold; Sensory System Agents; Skin; Transient Receptor Potential Channels; Young Adult | 2011 |
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Topics: Acrylamides; Anilides; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antioxidants; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cinnamates; Cromolyn Sodium; Disease Models, Animal; Diterpenes; Edema; Gabexate; Histamine; Male; Mast Cells; Methysergide; Pain; Promethazine; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Serotonin; Serotonin Antagonists; Tritium; TRPV Cation Channels; Uric Acid | 2011 |
Octreotide inhibits capsaicin-induced activation of C and Aδ afferent fibres in rat hairy skin in vivo.
Topics: Afferent Pathways; Animals; Capsaicin; Gastrointestinal Agents; Hair; Hot Temperature; Nerve Fibers; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Conduction; Neurons, Afferent; Nociceptors; Octreotide; Pain; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Sensory System Agents; Skin | 2011 |
Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response.
Topics: Animals; Behavior, Animal; Capsaicin; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Pain; Pain Measurement; Peptide Fragments; Phosphorylation; Protein Kinase Inhibitors; Substance P | 2011 |
Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
Topics: Animals; Capsaicin; Cyclic AMP Response Element-Binding Protein; Hyperalgesia; Immunohistochemistry; Male; Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sumatriptan; Trigeminal Caudal Nucleus; Tryptamines | 2011 |
Treatment of knee osteoarthritis.
Topics: Acupuncture Therapy; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Braces; Capsaicin; Evidence-Based Medicine; Exercise Therapy; Glucocorticoids; Glucosamine; Humans; Injections, Intra-Articular; Ointments; Osteoarthritis, Knee; Pain; Physical Therapy Modalities; Range of Motion, Articular; Risk Factors; Tai Ji; Treatment Outcome; Weight Loss | 2011 |
New developments in the medicinal chemistry of vanilloid TRPV1 and related receptors.
Topics: Animals; Capsaicin; Chemistry, Pharmaceutical; Humans; Pain; Transient Receptor Potential Channels; TRPV Cation Channels | 2011 |
Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Inhibitory Concentration 50; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Naloxone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pain Perception; Peptide Fragments; Receptors, Opioid; Spinal Cord; Structure-Activity Relationship | 2011 |
Chili anyone?
Topics: Analgesics; Capsaicin; Capsicum; Food-Drug Interactions; Humans; Pain; Substance P | 2011 |
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
Topics: Action Potentials; Anemia, Sickle Cell; Animals; Capsaicin; Disease Models, Animal; Female; Humans; Hyperalgesia; Hypoxia; Isoquinolines; Male; Mice; Mice, Inbred Strains; Microelectrodes; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; TRPV Cation Channels; Urea | 2011 |
17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Cell Line; Docosahexaenoic Acids; Freund's Adjuvant; Ganglia, Spinal; HEK293 Cells; Hot Temperature; Humans; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Pain; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; TRPV Cation Channels | 2012 |
Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica.
Topics: Adult; Capsaicin; Case-Control Studies; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Models, Theoretical; Pain; Pain Measurement; Sciatica; Sensory System Agents | 2012 |
Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators.
Topics: Animals; Blood Glucose; Body Weight; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Diterpenes; Glucose Tolerance Test; Hyperalgesia; Hyperglycemia; Inflammation Mediators; Injections, Intraperitoneal; Injections, Spinal; Insulin; Microglia; Pain; Posterior Horn Cells; Rats; Streptozocin; TRPV Cation Channels | 2011 |
Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions.
Topics: 2-Hydroxyphenethylamine; Administration, Oral; Analysis of Variance; Animals; Capsaicin; Denervation; Dose-Response Relationship, Drug; Foot; Injections; Injections, Spinal; Male; Neuralgia; Pain; Pain Measurement; Peripheral Nerves; Physical Stimulation; Pyrazoles; Rats; Rats, Wistar; Receptors, Serotonin; Sciatic Neuropathy; Serotonin Receptor Agonists; Spinal Cord | 2012 |
Capsaicin induces reflex scratching in inflamed skin.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Capsaicin; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Freund's Adjuvant; Inflammation; Injections, Intradermal; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Pain; Pruritus; Receptors, Opioid, mu; Reflex; Sensory System Agents; Skin; Time Factors; TRPV Cation Channels | 2011 |
Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain.
Topics: Animals; Capsaicin; Freund's Adjuvant; Functional Laterality; GABAergic Neurons; Glycine; Inflammation; Male; Molecular Imaging; Neuralgia; Neurons; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord | 2011 |
Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
Topics: Amino Acids; Animals; Calcium; Capsaicin; Cells, Cultured; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Skin; TRPV Cation Channels; Xanthenes | 2011 |
Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats.
Topics: Animals; Brain Stem; Capsaicin; Cervical Vertebrae; Deglutition; Electromyography; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Irritants; Male; Masseter Muscle; Mastication; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Trigeminal Nucleus, Spinal | 2011 |
Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.
Topics: Action Potentials; Animals; Apoptosis; Capsaicin; Cell Size; Cell Survival; Cyclin-Dependent Kinase 5; Ganglia, Spinal; HIV-1; Male; Neurons; Pain; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2011 |
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
Topics: Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Knockout; Neurons; Neurons, Afferent; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Tachykinins | 2011 |
Type III Nrg1 back signaling enhances functional TRPV1 along sensory axons contributing to basal and inflammatory thermal pain sensation.
Topics: Animals; Axons; Capsaicin; Cells, Cultured; Immunoblotting; Inflammation; Male; Mice; Mice, Knockout; Neuregulin-1; Pain; Patch-Clamp Techniques; Sensation; Sensory Receptor Cells; Sensory System Agents; Signal Transduction; Thermosensing; TRPV Cation Channels | 2011 |
A trigeminoreticular pathway: implications in pain.
Topics: Animals; Brain; Capsaicin; Neurons; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reticular Formation; Thalamus; Trigeminal Nucleus, Spinal | 2011 |
Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Inflammation; Male; Morphine; Narcotics; Pain; Pain Measurement; Pyridines; Quinolines; Rats; Rats, Inbred F344; Receptors, Metabotropic Glutamate | 2011 |
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.
Topics: Analgesics; Animals; Animals, Newborn; Capsaicin; Deamino Arginine Vasopressin; Disease Models, Animal; Female; Genetic Association Studies; Habituation, Psychophysiologic; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Weight; Pain; Pain Measurement; Pain Threshold; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Receptors, Vasopressin; Sex Factors; Stress, Psychological; Vasopressins | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.
Topics: Acid Sensing Ion Channels; Amino Acid Sequence; Animals; Capsaicin; Cells, Cultured; Elapid Venoms; Elapidae; Hindlimb; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Male; Mice; Mice, Knockout; Molecular Sequence Data; Nerve Tissue Proteins; Nociception; Oocytes; Pain; Protein Multimerization; Protein Structure, Quaternary; Protons; Rats; Sensory Receptor Cells; Sodium Channel Agonists; Sodium Channels; TRPV Cation Channels; Xenopus laevis | 2011 |
The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.
Topics: Ambroxol; Aniline Compounds; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Hot Temperature; Hyperalgesia; Injections, Spinal; Ischemia; Male; NAV1.8 Voltage-Gated Sodium Channel; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Time Factors | 2012 |
Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates.
Topics: Amphibian Proteins; Animals; Base Sequence; Capsaicin; Evoked Potentials; Evolution, Molecular; Ganglia, Spinal; HeLa Cells; Humans; Molecular Sequence Data; Oocytes; Pain; Sensory System Agents; Taste; Thermosensing; TRPV Cation Channels; Xenopus | 2012 |
Ask the doctor. I have pain from osteoarthritis in both knees. I'm curious about the cream made from a substance in hot peppers. How does it relieve pain?
Topics: Administration, Topical; Capsaicin; Capsicum; Humans; Osteoarthritis, Knee; Pain; Sensory System Agents | 2011 |
Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats.
Topics: Analgesics, Non-Narcotic; Animals; Bradykinin; Capsaicin; Carrageenan; Chalcone; Cyclooxygenase 2; Drugs, Chinese Herbal; Ganglia, Spinal; Inflammation; Male; Pain; Plant Extracts; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Substance P; Tachykinins | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
Absence of mechanical hyperalgesia after exercise (delayed onset muscle soreness) in neonatally capsaicin-treated rats.
Topics: Animals; Animals, Newborn; Capsaicin; Hyperalgesia; Male; Muscle Contraction; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
Effects of perceived and exerted pain control on neural activity during pain relief in experimental heat hyperalgesia: a fMRI study.
Topics: Adult; Brain; Capsaicin; Cerebral Cortex; Hot Temperature; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Pain; Pain Management; Pain Measurement; Perception; Prefrontal Cortex; Young Adult | 2012 |
The involvement of the spinal release of glutamate and nitric oxide in peripheral noxious stimulation-induced pain-related behaviors--study in mouse spinal microdialysis.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glutamic Acid; Male; Mice; Microdialysis; Nitric Oxide; Pain; Pain Measurement; Spinal Cord | 2012 |
Nabilone in inflammatory pain: to be or not to be.
Topics: Capsaicin; Central Nervous System; Dronabinol; Humans; Male; Pain; Pain Measurement | 2012 |
Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Colitis; Colon; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hydrogen Sulfide; Intestinal Mucosa; Male; Mucous Membrane; Neurons; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Rats; Rats, Wistar; Sensory Receptor Cells; Spine; Trinitrobenzenesulfonic Acid | 2012 |
Endothelin-1 induces itch and pain in the mouse cheek model.
Topics: Animals; Behavior, Animal; Capsaicin; Cheek; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Histamine; Injections, Intradermal; Male; Mice; Pain; Pruritus; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Histamine H1; Receptors, Opioid, mu | 2012 |
Augmented activity of the pelvic nerve afferent mediated by TRP channels in dextran sulfate sodium (DSS)-induced colitis of rats.
Topics: Acetic Acid; Animals; Capsaicin; Colitis; Dextran Sulfate; Electrophysiological Phenomena; Male; Neurons, Afferent; Pain; Rats; Rats, Inbred WKY; Ruthenium Red; Transient Receptor Potential Channels | 2012 |
The antinociceptive activity of harmicine on chemical-induced neurogenic and inflammatory pain models in mice.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Indole Alkaloids; Male; Mice; Neurogenic Inflammation; Pain; Pain Measurement; Reaction Time | 2012 |
Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity.
Topics: Adiponectin; Animals; Capsaicin; Carrageenan; Down-Regulation; Edema; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Morphine; Nitric Oxide Synthase Type II; Nociception; Obesity; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; Receptors, Leptin; RNA, Messenger; Spinal Cord; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Chloroquine; Female; Ganglia, Spinal; Green Fluorescent Proteins; Histamine; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Muscles; Mustard Plant; Pain; Plant Oils; Posterior Horn Cells; Pruritus; Sensory Receptor Cells; Skin; TRPM Cation Channels; TRPV Cation Channels | 2012 |
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
Topics: Analgesics; Animals; Body Temperature; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Transformed; Fever; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C3H; Neurons; Pain; Protons; Rats; Rats, Sprague-Dawley; Recombinant Proteins; TRPV Cation Channels | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.
Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Calcium; Capsaicin; Chromatography, High Pressure Liquid; Diterpenes; Edema; Freund's Adjuvant; Hot Temperature; Male; Mice; Nociceptors; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Stigmasterol; Tissue Distribution; TRPV Cation Channels; Vernonia | 2012 |
The effect of nerve compression and capsaicin on contact heat-evoked potentials related to Aδ- and C-fibers.
Topics: Adult; Analysis of Variance; Capsaicin; Electroencephalography; Evoked Potentials, Somatosensory; Female; Hot Temperature; Humans; Male; Nerve Compression Syndromes; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Pain; Reaction Time; Sensory System Agents; Skin; Statistics, Nonparametric; Young Adult | 2012 |
Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin.
Topics: Animals; Blotting, Western; Calbindin 2; Calcium; Capsaicin; Cell Membrane; Cell Size; Ganglia, Spinal; Immunoenzyme Techniques; Mice; Neurons; NIH 3T3 Cells; Pain; Rats; S100 Calcium Binding Protein G; Sensory System Agents; Sodium; TRPV Cation Channels | 2013 |
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxylic Acids; Diazepam; Endpoint Determination; GABA Antagonists; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Pain; Physical Stimulation; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 2012 |
Positive allosteric modulation of TRPV1 as a novel analgesic mechanism.
Topics: Activating Transcription Factor 3; Analgesics; Animals; Capsaicin; Dihydropyridines; Ganglia, Spinal; Immunohistochemistry; Male; Nociception; Pain; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; TRPV Cation Channels | 2012 |
Obesity increases nociceptive activation of the trigeminal system.
Topics: Animals; Capsaicin; Diet, High-Fat; Female; Male; Mice; Mice, Inbred C57BL; Neurons; Nociceptive Pain; Obesity; Pain; Proto-Oncogene Proteins c-fos; Trigeminal Caudal Nucleus | 2013 |
Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Clodronic Acid; Corticosterone; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; Etidronic Acid; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Pain; Proto-Oncogene Proteins c-fos | 2013 |
Mitochondria and plasma membrane Ca2+-ATPase control presynaptic Ca2+ clearance in capsaicin-sensitive rat sensory neurons.
Topics: Animals; Animals, Newborn; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Coculture Techniques; Ganglia, Spinal; Mitochondria; Pain; Plasma Membrane Calcium-Transporting ATPases; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Cord; Synapses | 2013 |
Material basis for inhibition of dragon's blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Chalcone; Female; Ganglia, Spinal; Hot Temperature; In Vitro Techniques; Male; Pain; Plant Extracts; Rats; Rats, Wistar; Resins, Plant; TRPV Cation Channels | 2013 |
Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
Topics: Acetic Acid; Aminopyrine; Analgesics, Non-Narcotic; Animals; Capsaicin; Formaldehyde; Imides; Indicators and Reagents; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peritonitis; Reaction Time; Structure-Activity Relationship | 2002 |
5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
Topics: Anesthetics, General; Animals; Area Postrema; Brain Stem; Capsaicin; Carbazoles; Chloralose; Cisterna Magna; Dose-Response Relationship, Drug; Fluorobenzenes; Gene Expression Regulation; Genes, fos; Hemodynamics; Injections; Male; Mice; Models, Animal; Nerve Tissue Proteins; Pain; Proto-Oncogene Proteins c-fos; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT1F; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Synaptic Transmission; Trigeminal Caudal Nucleus; Urethane; Vasomotor System | 2002 |
Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors.
Topics: Administration, Oral; Animals; Capsaicin; Cervical Vertebrae; Injections, Intraventricular; Irritants; Male; Medulla Oblongata; Neurons; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Solutions; Spinal Cord; Substance P | 2002 |
4-Nitro-1,8-naphthalimides exhibit antinociceptive properties.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Imides; Injections, Intraperitoneal; Male; Mice; Naphthalenes; Pain; Pain Measurement | 2002 |
Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.
Topics: Amino Acid Sequence; Animals; Capsaicin; Hot Temperature; Hyperalgesia; Male; Pain; Peptide Fragments; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Thrombin | 2002 |
Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats.
Topics: Animals; Capsaicin; Dopamine; Dopamine Antagonists; Drug Administration Routes; Drug Implants; Drug Tolerance; Extracellular Space; Male; Microdialysis; Microinjections; Morphine; Nicotinic Antagonists; Nucleus Accumbens; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex | 2002 |
Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons.
Topics: Amino Acid Sequence; Animals; Base Sequence; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Capsaicin; Cell Compartmentation; Cell Membrane; Gene Expression Regulation; Ion Channels; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Nervous System; Neurons, Afferent; Pain; Phylogeny; Receptors, Drug; Sensation; Signal Transduction; Transient Receptor Potential Channels; TRPV Cation Channels | 2002 |
Upregulation of neurokinin-1 receptor expression in rat spinal cord by an N-terminal metabolite of substance P.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunohistochemistry; Inflammation; Isomerism; Male; Pain; Peptide Fragments; Posterior Horn Cells; Presynaptic Terminals; Protein Precursors; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins; Up-Regulation | 2002 |
cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.
Topics: Amino Acid Sequence; Animals; Binding Sites; Capsaicin; Central Nervous System; CHO Cells; COS Cells; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Mutation; Neurons, Afferent; Nociceptors; Pain; Phosphorylation; Protein Structure, Tertiary; Receptors, Drug; Recombinant Fusion Proteins; Serine; Transfection | 2002 |
Capsaicin-induced muscle pain alters the excitability of the human jaw-stretch reflex.
Topics: Adult; Afferent Pathways; Analysis of Variance; Capsaicin; Electromyography; Female; Humans; Male; Masseter Muscle; Matched-Pair Analysis; Motor Neurons, Gamma; Muscle Contraction; Nerve Fibers; Nociceptors; Pain; Pain Measurement; Reaction Time; Reflex, Stretch; Signal Processing, Computer-Assisted; Statistics as Topic; Temporal Muscle; Time Factors | 2002 |
Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem.
Topics: Analysis of Variance; Animals; Antibodies, Monoclonal; Brain Stem; Capsaicin; Cervical Plexus; Female; Image Processing, Computer-Assisted; Immunohistochemistry; Injections, Intra-Articular; Neural Pathways; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Rabbits; Statistics as Topic; Substance P; Temporomandibular Joint; Trigeminal Caudal Nucleus; Trigeminal Nuclei; Trigeminal Nucleus, Spinal | 2002 |
Intra-ureteric capsaicin in loin pain haematuria syndrome: efficacy and complications.
Topics: Adult; Analgesics, Opioid; Capsaicin; Female; Hematuria; Humans; Kidney Transplantation; Male; Pain; Pilot Projects; Pregnancy; Pregnancy Complications; Prospective Studies; Syndrome; Time Factors; Treatment Outcome | 2002 |
Cloning and functional characterization of the guinea pig vanilloid receptor 1.
Topics: Aequorin; Amino Acid Sequence; Animals; Calcium; Capsaicin; CHO Cells; Chronic Disease; Cloning, Molecular; Cricetinae; Fluorescent Dyes; Fura-2; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Luminescent Measurements; Molecular Sequence Data; Pain; Rats; Receptors, Drug; TRPV Cation Channels | 2002 |
Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.
Topics: Acetylcholine; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Capsaicin; Colitis; Colon; Cyclophosphamide; Cystitis; Disease Models, Animal; Drug Administration Routes; Homozygote; Hyperalgesia; Male; Mice; Mice, Knockout; Mustard Plant; NAV1.8 Voltage-Gated Sodium Channel; Neuropeptides; Pain; Pain Measurement; Plant Extracts; Plant Oils; Sodium Channels; Stimulation, Chemical; Urinary Bladder; Viscera | 2002 |
Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.
Topics: Acid Sensing Ion Channels; Adult; Amiloride; Animals; Capsaicin; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Proteins; Nerve Tissue Proteins; Nociceptors; Oocytes; Pain; Psychophysics; Rats; Receptors, Drug; Recombinant Proteins; Sodium Channels; Xenopus | 2002 |
The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons.
Topics: Afferent Pathways; Animals; Calcium Signaling; Capsaicin; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Immunohistochemistry; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Drug; Ruthenium Red; Synaptic Transmission; Thermosensing; TRPV Cation Channels | 2002 |
Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET).
Topics: Adult; Area Under Curve; Brain; Capsaicin; Carbon Radioisotopes; Fentanyl; Humans; Male; Middle Aged; Narcotics; Neural Pathways; Pain; Pain Measurement; Receptors, Opioid, mu; Tomography, Emission-Computed | 2002 |
Functional imaging of the rat cervical spinal cord.
Topics: Afferent Pathways; Animals; Capsaicin; Electric Stimulation; Forelimb; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Immunohistochemistry; Male; Pain; Rats; Rats, Wistar; Receptors, Drug; Substance P; Taste; Taste Buds; Tongue | 2002 |
Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats.
Topics: Animals; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique; Injections, Intradermal; Male; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinothalamic Tracts; Synaptic Transmission | 2002 |
Notalgia paresthetica with a significant increase in the number of intradermal nerves.
Topics: Administration, Topical; Adult; Biopsy, Needle; Capsaicin; Female; Humans; Immunohistochemistry; Pain; Paresthesia; Prognosis; Pruritus; Skin; Skin Diseases | 2002 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosides; GTP-Binding Proteins; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels; Steroids; Tetraethylammonium | 2003 |
A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans.
Topics: Analysis of Variance; Bee Venoms; Capsaicin; Humans; Hyperalgesia; Injections, Intradermal; Melitten; Neurogenic Inflammation; Pain; Pain Measurement; Physical Stimulation; Regional Blood Flow; Skin; Time Factors | 2003 |
Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow.
Topics: Adrenergic Fibers; Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stimulation; Guanethidine; Hindlimb; Male; Naloxone; Nociceptin; Opioid Peptides; Pain; Rats; Rats, Wistar; Regional Blood Flow; Sympathetic Nervous System; Synovial Membrane; Vasoconstriction | 2003 |
Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors.
Topics: Animals; Capsaicin; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nerve Growth Factors; Neurons, Afferent; Nociceptors; Pain; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; ras Proteins; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Drug; Up-Regulation | 2003 |
Intra-ureteric capsaicin in loin pain haematuria syndrome: efficacy and complications.
Topics: Capsaicin; Drug Administration Routes; Hematuria; Humans; Pain; Prospective Studies; Syndrome; Treatment Outcome | 2003 |
Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain.
Topics: Analgesia; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Gene Expression; Hot Temperature; Hyperalgesia; Male; Mice; Nerve Fibers; Pain; Pain Measurement; Receptors, Drug; TRPV Cation Channels | 2003 |
In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord.
Topics: Animals; Blotting, Western; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hot Temperature; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pressure; Receptors, Neurokinin-1; Reflex; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Substance P; Synaptic Membranes; Synaptic Transmission | 2003 |
Anti-inflammatory and antinociceptive activity of diphenyl diselenide.
Topics: Abdominal Muscles; Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Benzene Derivatives; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Isoindoles; Male; Mice; Muscle Contraction; Nociceptors; Organoselenium Compounds; Pain; Pain Measurement; Rats; Rats, Wistar | 2003 |
Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.
Topics: Analgesics, Opioid; Animals; C-Peptide; Capsaicin; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Male; Mice; Nociceptin; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Peptide Fragments; Signal Transduction; Vasodilator Agents | 2003 |
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
State-dependent phosphorylation of epsilon-isozyme of protein kinase C in adult rat dorsal root ganglia after inflammation and nerve injury.
Topics: Animals; Behavior, Animal; Capsaicin; Carrageenan; Disease Models, Animal; Diterpenes; Freund's Adjuvant; Ganglia, Spinal; Hindlimb; Hyperalgesia; Inflammation; Ligation; Male; Neurons; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.
Topics: Afferent Pathways; Animals; Capsaicin; Diabetic Neuropathies; Disease Models, Animal; Hot Temperature; Hyperalgesia; Injections, Intravenous; Mice; Nerve Fibers, Myelinated; Neurons, Afferent; Pain; Phenotype; Receptors, Drug; Streptozocin | 2003 |
TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate.
Topics: Animals; Behavior, Animal; Capsaicin; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Electrophysiology; Eye; Ganglia, Spinal; Irritants; Male; Mice; Mouth; Nerve Endings; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Rats; Receptors, Drug; Skin; Taste | 2003 |
Aftersensations in experimental and clinical hypersensitivity.
Topics: Adult; Aged; Aged, 80 and over; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Pain; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Physical Stimulation; Time Factors; Wounds and Injuries | 2003 |
Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Foot; Injections; Male; Mice; Nociceptors; Pain; Receptors, Drug; Ruthenium Red | 2003 |
A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Hyperalgesia; Ligation; Male; Meloxicam; Morphine; Pain; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazines; Thiazoles; Thymic Factor, Circulating; Time Factors | 2003 |
The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice.
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Evodia; Fruit; Ileum; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Quinazolines | 2003 |
A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.
Topics: Amino Acid Sequence; Amino Acids; Calcium Signaling; Capsaicin; Cell Line; Cell Membrane; Humans; Membrane Potentials; Mutation; Neurons, Afferent; Nociceptors; Pain; Protein Structure, Tertiary; Protons; Receptors, Drug; Sodium Channels; Tyrosine | 2003 |
Adrenergic regulation of capsaicin-sensitive neurons in dental pulp.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cattle; Clonidine; Dental Pulp; Epinephrine; Ion Channels; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Receptors, Adrenergic, alpha; Receptors, Drug | 2003 |
Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation.
Topics: Aminobutyrates; Analgesics; Animals; Benzeneacetamides; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dynorphins; Female; Ketamine; Macaca mulatta; Pain; Pain Measurement; Peptide Fragments; Pyrrolidines | 2003 |
Evaluations of inhibitory effect on the motor cortex by cutaneous pain via application of capsaicin.
Topics: Administration, Cutaneous; Adult; Arm; Capsaicin; Electric Stimulation; Evoked Potentials, Motor; Female; Humans; Magnetics; Male; Motor Cortex; Muscle, Skeletal; Neural Inhibition; Pain; Pain Measurement; Reaction Time; Reference Values | 2003 |
Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization.
Topics: Animals; Ankle Joint; Blood Gas Analysis; Blood Pressure; Capsaicin; Disease Models, Animal; Forelimb; Hyperalgesia; Injections, Intra-Articular; Injections, Subcutaneous; Lumbosacral Region; Magnetic Resonance Imaging; Pain; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Spinal Cord; Stimulation, Chemical | 2003 |
A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.
Topics: Analgesia; Animals; Behavior, Animal; Capsaicin; Cell Count; Drug Administration Routes; Drug Interactions; Formaldehyde; Freund's Adjuvant; Male; Microscopy, Electron; Pain; Pain Measurement; Peptides; Peptides, Cyclic; Peripheral Nerves; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Time Factors | 2003 |
Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key.
Topics: Administration, Topical; Animals; Antipruritics; Capsaicin; Humans; Menthol; Pain; Pruritus Ani; Receptors, Drug; Thermoreceptors | 2003 |
Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models.
Topics: Administration, Oral; Analgesics; Angelica; Animals; Capsaicin; Cytokines; Excitatory Amino Acids; Formaldehyde; Hot Temperature; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Plant Extracts; Plant Roots; Postural Balance; Reaction Time; Substance P | 2003 |
Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin.
Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Evoked Potentials; Female; Functional Laterality; Hand; Humans; Hyperalgesia; Injections, Intradermal; Low-Level Light Therapy; Male; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Psychophysics; Reaction Time; Skin; Time Factors | 2003 |
Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons.
Topics: Animals; Animals, Newborn; Apoptosis; Capsaicin; Cell Membrane Permeability; Cells, Cultured; Cyclosporine; DNA Fragmentation; Ganglia, Spinal; Humans; Intracellular Membranes; Mitochondria; Neurons, Afferent; Neurotoxins; Pain; Permeability; Rats; Receptors, Drug; Transfection | 2003 |
Protein kinases regulate the phosphorylation of the GluR1 subunit of AMPA receptors of spinal cord in rats following noxious stimulation.
Topics: Amino Acid Sequence; Animals; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Inflammation; Male; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine | 2003 |
Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor in rats following intradermal injection of capsaicin.
Topics: Animals; Blotting, Western; Capsaicin; Immunohistochemistry; Injections, Intradermal; Male; Neurons; Pain; Pain Threshold; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine; Spinal Cord | 2003 |
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Capsaicin; Cassia; Dipyrone; Dose-Response Relationship, Drug; Flowers; Formaldehyde; Fruit; Hot Temperature; Indomethacin; Male; Mice; Pain; Phytotherapy; Piperidines; Plant Extracts | 2003 |
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.
Topics: Analgesics; Animals; Cannabinoids; Capsaicin; Disease Models, Animal; Hyperalgesia; Injections, Intradermal; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2 | 2004 |
Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Topics: Analgesics; Animals; Capsaicin; Mice; Models, Molecular; Molecular Conformation; Pain; Receptors, Drug; Structure-Activity Relationship | 2003 |
Contribution of spinal inhibitory receptors in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Bicuculline; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Electrodes, Implanted; Electromyography; GABA Antagonists; Glycine Agents; Male; Models, Neurological; Narcotic Antagonists; Neural Inhibition; Nucleus Accumbens; Organophosphorus Compounds; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Strychnine | 2003 |
The effects of protein phosphatase inhibitors on nociceptive behavioral responses of rats following intradermal injection of capsaicin.
Topics: Animals; Capsaicin; Enzyme Inhibitors; Injections, Intradermal; Male; Pain; Pain Measurement; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Reaction Time | 2003 |
Comparative EEG activation to skin pain and muscle pain induced by capsaicin injection.
Topics: Adult; Analysis of Variance; Brain Mapping; Capsaicin; Electroencephalography; Humans; Muscles; Pain; Pain Measurement; Random Allocation; Skin | 2004 |
New compound fires up pain research.
Topics: Anilides; Animals; Capsaicin; Cinnamates; Humans; Nociceptors; Pain; Rats; Receptors, Drug | 2003 |
Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin.
Topics: Animals; Arginine; Benzazepines; Bicuculline; Capsaicin; Foot; GABA Antagonists; Inflammation; Injections, Spinal; Laser-Doppler Flowmetry; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Skin; Spinal Cord; Sympathectomy; Sympathetic Nervous System | 2004 |
Ca2+/calmodulin modulates TRPV1 activation by capsaicin.
Topics: Animals; Calcium; Calmodulin; Capsaicin; Electrophysiology; Hot Temperature; Ion Channel Gating; Neurons, Afferent; Oocytes; Pain; Receptors, Drug; Xenopus | 2004 |
Cell-specific alternative splicing increases calcium channel current density in the pain pathway.
Topics: Alternative Splicing; Animals; Calcium Channels, L-Type; Calcium Channels, N-Type; Capsaicin; Electric Conductivity; Exons; Ganglia, Spinal; Neurons; Nociceptors; Pain; Protein Isoforms; Rats; Rats, Sprague-Dawley | 2004 |
Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron.
Topics: Acetylcholine; Analysis of Variance; Animals; Arecoline; Atropine; Behavior, Animal; Bungarotoxins; Calcitonin Gene-Related Peptide; Capsaicin; Cell Count; Disinfectants; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Formaldehyde; Gallamine Triethiodide; Gene Expression Regulation; Grooming; In Situ Hybridization; In Vitro Techniques; Male; Mecamylamine; Mouth Mucosa; Muscarinic Antagonists; Neurons, Afferent; Nicotinic Antagonists; Pain; Pain Measurement; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Drug; RNA, Messenger; Time; Trigeminal Ganglion | 2004 |
Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception.
Topics: Animals; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Endocannabinoids; Hypotension; Male; Neurons; Nitroprusside; Pain; Peptide Fragments; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Trigeminal Caudal Nucleus; Vasodilation | 2004 |
Evoked pain in the motor endplate region of the brachial biceps muscle: an experimental study.
Topics: Adult; Capsaicin; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Myofascial Pain Syndromes; Neuromuscular Junction; Nociceptors; Pain; Pain Measurement; Reference Values; Saline Solution, Hypertonic; Sensory Receptor Cells; Surveys and Questionnaires | 2004 |
Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain.
Topics: Action Potentials; Adult; Aged; Capsaicin; Female; Ganglia, Spinal; Humans; Male; Middle Aged; Neurons, Afferent; Pain; Potassium Channels; Protons; Receptors, Drug | 2004 |
Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicin.
Topics: Adult; Affect; Analysis of Variance; Ankle; Anxiety; Capsaicin; Face; Female; Heart Rate; Humans; Linear Models; Male; Middle Aged; Pain; Pain Measurement; Perception; Psychophysics; Sex Characteristics; Time Factors | 2004 |
Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.
Topics: Administration, Rectal; Animals; Behavior, Animal; Capsaicin; Colon; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Oligopeptides; Pain; Pain Measurement; Peptides; Receptor, PAR-1; Receptor, PAR-2; Time Factors; Up-Regulation; Viscera | 2004 |
It's not just about rubbing--topical capsaicin and topical salicylates may be useful as adjuvants to conventional pain treatment.
Topics: Administration, Topical; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chemotherapy, Adjuvant; Humans; Pain; Salicylates | 2004 |
Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects.
Topics: Adolescent; Adult; Afferent Pathways; Capsaicin; Female; Humans; Hypesthesia; Male; Mechanoreceptors; Middle Aged; Nerve Fibers, Unmyelinated; Neural Inhibition; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Pain; Peripheral Nervous System Diseases; Presynaptic Terminals; Skin; Synaptic Transmission; Touch | 2004 |
Direct evidence for activation and desensitization of the capsaicin receptor by N-oleoyldopamine on TRPV1-transfected cell, line in gene deleted mice and in the rat.
Topics: Animals; Behavior, Animal; Calcium Signaling; Capsaicin; Cell Line, Tumor; Dopamine; Dose-Response Relationship, Drug; Hot Temperature; Humans; Ligands; Mice; Mice, Knockout; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Rats; Receptors, Drug; Transfection | 2004 |
Presynaptic inhibition and spinal pain processing in mice: a possible role of the NKCC1 cation-chloride co-transporter in hyperalgesia.
Topics: Afferent Pathways; Animals; Capsaicin; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Presynaptic Terminals; Reaction Time; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Nerve Roots; Synaptic Transmission | 2004 |
Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates.
Topics: Administration, Topical; Analgesics; Animals; Capsaicin; Dopamine; Female; Fentanyl; Loperamide; Macaca mulatta; Pain; Pain Measurement | 2004 |
Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; In Vitro Techniques; Male; Mice; Mice, Knockout; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, Drug; Ruthenium Red; Sensory Receptor Cells; Signal Transduction; Skin | 2004 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interactions; Hyperalgesia; Injections, Intramuscular; Injections, Spinal; Male; Melatonin; Neural Inhibition; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Cord; Spinal Cord Injuries; Tetrahydronaphthalenes; Tryptamines | 2004 |
Distinctive pattern of c-fos expression in the feline cervico-lumbar spinal cord after stimulation of vanilloid receptors in dorsal neck muscles.
Topics: Animals; Capsaicin; Cats; Cell Size; Cervical Vertebrae; Female; Genes, fos; Histocytochemistry; Injections; Lumbar Vertebrae; Male; Neck Muscles; Neural Pathways; Pain; Receptors, Drug; Spinal Cord; Stimulation, Chemical | 2004 |
Neural activation during experimental allodynia: a functional magnetic resonance imaging study.
Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Female; Functional Laterality; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Neurons; Pain; Pain Measurement; Physical Stimulation | 2004 |
Here's the rub on painkilling creams.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Capsaicin; Humans; Ointments; Pain; Salicylates | 2004 |
The effect of cutaneous mast cell degranulation on sensitivity to heat.
Topics: Adolescent; Adult; Axons; Capsaicin; Hot Temperature; Humans; Inflammation; Iontophoresis; Leukocytes; Male; Mast Cells; Norepinephrine; p-Methoxy-N-methylphenethylamine; Pain; Sensitivity and Specificity; Skin; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Chemical nociception in the jejunum induced by capsaicin.
Topics: Abdomen; Adult; Body Temperature; Capsaicin; Drug Administration Schedule; Female; Gastrointestinal Motility; Humans; Jejunum; Male; Nociceptors; Pain; Perception; Perfusion; Pressure; Sensory Thresholds; Time Factors | 2004 |
Pro-nociceptive role of peripheral galanin in inflammatory pain.
Topics: Action Potentials; Animals; Axons; Behavior, Animal; Capsaicin; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Galanin; Immunohistochemistry; In Vitro Techniques; Inflammation; Male; Microscopy, Electron; Pain; Pain Measurement; Peptide Fragments; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Receptor, Galanin, Type 2; Receptors, Drug; Skin; Substance P | 2004 |
Role of capsaicin-sensitive primary afferent inputs from the masseter muscle in the C1 spinal neurons responding to tooth-pulp stimulation in rats.
Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Cervical Atlas; Dental Pulp Cavity; Dose-Response Relationship, Drug; Electric Stimulation; Functional Laterality; Hot Temperature; Male; Masseter Muscle; Muscle Contraction; Mustard Plant; Neck Muscles; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Plant Extracts; Plant Oils; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Drug; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Ganglion | 2005 |
Effect of protein kinase C blockade on phosphorylation of NR1 in dorsal horn and spinothalamic tract cells caused by intradermal capsaicin injection in rats.
Topics: Alkaloids; Animals; Benzophenanthridines; Capsaicin; Enzyme Inhibitors; Fluorescent Antibody Technique; Functional Laterality; Injections, Intradermal; Injections, Spinal; Male; Nociceptors; Pain; Phenanthridines; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinothalamic Tracts | 2004 |
Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials.
Topics: Adult; Afferent Pathways; Brain; Capsaicin; Electroencephalography; Evoked Potentials, Somatosensory; Female; Functional Laterality; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Nociceptors; Pain; Reaction Time; Thermosensing; Trigeminal Nerve | 2005 |
A reliable method for the preferential activation of C- or A-fibre heat nociceptors.
Topics: Animals; Capsaicin; Electromyography; Hot Temperature; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Rats; Rats, Wistar; Reaction Time; Sensory Thresholds; Skin Temperature | 2004 |
Regulation mechanisms of vanilloid receptors.
Topics: Adenosine Triphosphate; Animals; Capsaicin; Hot Temperature; Humans; Inflammation; Mice; Models, Neurological; Neurons, Afferent; Nociceptors; Pain; Rats; Receptors, Drug; Receptors, Purinergic P2 | 2004 |
Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors.
Topics: Afferent Pathways; Animals; Capsaicin; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Male; Membrane Transport Proteins; Microscopy, Electron, Transmission; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Nerve Roots; Substance P; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2005 |
Effects of evoked pain on the electromyogram and compound muscle action potential of the brachial biceps muscle.
Topics: Action Potentials; Adult; Capsaicin; Electromyography; Female; Humans; Male; Middle Aged; Motor Endplate; Muscle Contraction; Muscle, Skeletal; Pain; Saline Solution, Hypertonic | 2005 |
Activation of TRPV1 in the VTA excites dopaminergic neurons and increases chemical- and noxious-induced dopamine release in the nucleus accumbens.
Topics: Animals; Axons; Capsaicin; Dopamine; Electrophysiology; In Vitro Techniques; Microdialysis; Neurons; Nucleus Accumbens; Pain; Patch-Clamp Techniques; Rats; Rats, Wistar; Stimulation, Chemical; Ventral Tegmental Area | 2005 |
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
Topics: Animals; Brain; Capsaicin; COS Cells; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Aromatic; Hyperalgesia; Male; Mice; Nitrogen; Pain; Pyrazoles; Pyridazines; Rats | 2005 |
Acid-induced pain and its modulation in humans.
Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Female; Forearm; Hot Temperature; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Hyperalgesia; Ibuprofen; Injections, Subcutaneous; Ion Channels; Iontophoresis; Male; Membrane Proteins; Middle Aged; Nerve Tissue Proteins; Pain; Pain Measurement; Pain Threshold; Refractory Period, Electrophysiological; Single-Blind Method; Sodium Channels; TRPV Cation Channels | 2004 |
Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.
Topics: Acrolein; Animals; Arachidonic Acids; Capsaicin; Cyclophosphamide; Cystitis; Endocannabinoids; Female; Hydrolysis; Ion Channels; Pain; Polyunsaturated Alkamides; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex, Abnormal; TRPV Cation Channels; Urinary Bladder | 2004 |
Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cyclic AMP Response Element-Binding Protein; Injections, Intradermal; Injections, Spinal; Male; Pain; Phosphorylation; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord | 2005 |
Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.
Topics: Amygdala; Animals; Auditory Cortex; Behavior, Animal; Capsaicin; Conditioning, Classical; Excitatory Postsynaptic Potentials; Fear; Formaldehyde; GluK2 Kainate Receptor; Hot Temperature; Inflammation; Male; Memory; Mice; Mice, Knockout; Neuronal Plasticity; Pain; Reaction Time; Receptors, Kainic Acid | 2005 |
mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hot Temperature; Male; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2005 |
[Effect of muscle pain on c-fos expression and NADPH-diaphorase activity in the spinal cord].
Topics: Animals; Capsaicin; Cats; Disease Models, Animal; Immunohistochemistry; NADPH Dehydrogenase; Neck Muscles; Neural Pathways; Neurons; Pain; Proto-Oncogene Proteins c-fos; Spinal Cord | 2004 |
Antinociceptive properties of acetylenic thiophene and furan derivatives: evidence for the mechanism of action.
Topics: Acetic Acid; Acetylene; Analgesics; Animals; Capsaicin; Dopamine Agents; Exploratory Behavior; Furans; Hot Temperature; Immersion; Male; Mice; Motor Activity; Muscarinic Antagonists; Muscle Contraction; Narcotic Antagonists; Pain; Pain Measurement; Pharmaceutical Solutions; Reaction Time; Receptors, Muscarinic; Thiophenes | 2005 |
Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation.
Topics: Amino Acid Transport System X-AG; Animals; Autonomic Denervation; Calcitonin Gene-Related Peptide; Capsaicin; Female; Ganglia, Spinal; Gastric Mucosa; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Ion Channels; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Symporters; Thoracic Vertebrae; TRPV Cation Channels; Visceral Afferents | 2005 |
Spinal opioid receptor like1 receptor agonist, but not N-methyl-D-aspartic acid antagonist, reverses the secondary mechanical allodynia induced by intradermal injection of capsaicin in rats.
Topics: Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Foot; Injections, Intradermal; Male; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord | 2005 |
Gene gun particle encoding preproenkephalin cDNA produces analgesia against capsaicin-induced bladder pain in rats.
Topics: Analgesia; Animals; Biolistics; Capsaicin; DNA, Complementary; Enkephalins; Female; Humans; Pain; Pain Management; Plasmids; Protein Precursors; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relationship, Drug; Edema; Formaldehyde; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Isoquinolines; Ligation; Male; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain, Postoperative; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Nerves; Urea | 2005 |
Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.
Topics: Animals; Botulinum Toxins, Type A; Capsaicin; Carrageenan; Hindlimb; Hyperalgesia; Male; Models, Animal; Nociceptors; Pain; Rats; Rats, Wistar | 2005 |
Three distinct categories of time course of pain produced by oral capsaicin.
Topics: Administration, Oral; Capsaicin; Cluster Analysis; Humans; Irritants; Models, Theoretical; Pain; Pain Threshold; Phenotype | 2005 |
Painful stimuli induce in vivo phosphorylation and membrane mobilization of mouse spinal cord NKCC1 co-transporter.
Topics: Animals; Blotting, Western; Capsaicin; Cell Membrane; Cytosol; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neural Pathways; Pain; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Spinal Cord; Subcellular Fractions | 2005 |
Capsaicin for the treatment of vulvar vestibulitis.
Topics: Adult; Capsaicin; Dyspareunia; Female; Humans; Pain; Physical Stimulation; Retrospective Studies; Treatment Outcome; Vulvitis | 2005 |
Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord.
Topics: Alkaloids; Animals; Animals, Newborn; Axotomy; Azocines; Binding Sites; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Down-Regulation; Heart Rate; Ion Channels; Male; Nerve Fibers, Unmyelinated; Neurotoxins; Nicotinic Agonists; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; TRPV Cation Channels | 2004 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-Response Relationship, Drug; Formaldehyde; Ketanserin; Male; Mice; Motor Activity; Naltrexone; Pain; Pain Measurement; Phytotherapy; Plant Preparations; Prazosin; Receptors, Serotonin, 5-HT2; Reserpine; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Yohimbine | 2005 |
Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling.
Topics: Adenosine Triphosphate; Aminobutyrates; Animals; Arachidonic Acids; Behavior, Animal; Bradykinin; Calcium; Calcium Channel Blockers; Capsaicin; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Endocannabinoids; Extracellular Space; Humans; Hydrogen-Ion Concentration; Magnesium Sulfate; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Models, Biological; Mutagenesis; Neurons; Nodose Ganglion; Oocytes; Pain; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Polyunsaturated Alkamides; Protein Kinase C; Signal Transduction; Temperature; Time Factors; Transfection; TRPV Cation Channels | 2005 |
Protein phosphatase modulates the phosphorylation of spinal cord NMDA receptors in rats following intradermal injection of capsaicin.
Topics: Administration, Cutaneous; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Glutamic Acid; Male; Microdialysis; Neurons, Afferent; Nociceptors; Pain; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 2005 |
Diverse immunocytochemical expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia.
Topics: Afferent Pathways; Animals; Capsaicin; Cell Size; Cells, Cultured; Ganglia, Spinal; Immunohistochemistry; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat.
Topics: Analgesics; Anilides; Animals; Capsaicin; Cells, Cultured; Cinnamates; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Ion Channels; Male; Mice; Mice, Inbred BALB C; Neurons, Afferent; Nociceptors; Pain; Peripheral Nervous System; Rats; Rats, Wistar; Sensory Receptor Cells; Substance P; Trigeminal Ganglion; TRPV Cation Channels | 2005 |
Attenuation of capsaicin-induced acute and visceral nociceptive pain by alpha- and beta-amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in mice.
Topics: Administration, Oral; Analgesics; Animals; Behavior, Animal; Burseraceae; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Hypothermia; Mice; Motor Activity; Oleanolic Acid; Pain; Postural Balance; Resins, Plant; Sleep | 2005 |
Antinociceptive effect of leaf essential oil from Croton sonderianus in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Croton; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Glyburide; Male; Mice; Oils, Volatile; Pain; Plant Leaves; Postural Balance; Potassium Channel Blockers; Sleep | 2005 |
Characteristics of propofol-evoked vascular pain in anaesthetized rats.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Animals; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Electromyography; Indomethacin; Injections, Intra-Arterial; Male; Muscle, Skeletal; Pain; Procaine; Propofol; Rats; Rats, Sprague-Dawley; Reflex | 2005 |
Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse.
Topics: Animals; Behavior, Animal; Capsaicin; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Physical Stimulation; Reaction Time; Receptors, Dopamine D2 | 2005 |
Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Injections, Spinal; Male; Nerve Tissue Proteins; Neuropeptides; Pain; Pain Measurement; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; TRPV Cation Channels; Up-Regulation | 2005 |
Effects of intraplantar injections of nociceptin and its N-terminal fragments on nociceptive and desensitized responses induced by capsaicin in mice.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Male; Mice; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Pain Measurement; Peptides; Receptors, Opioid; Vasodilator Agents | 2005 |
Functional role of prostacyclin receptor in rat dorsal root ganglion neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Cells, Cultured; Cyclic AMP; Cystitis, Interstitial; Disease Models, Animal; Female; Ganglia, Spinal; Iloprost; Inflammation Mediators; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Potassium Chloride; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Epoprostenol; Substance P; Vasodilator Agents | 2005 |
Heat and mechanical hyperalgesia in mice model of cancer pain.
Topics: Animals; Body Temperature; Capsaicin; Cell Count; Cell Line, Tumor; Cell Size; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Humans; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Pain; Pain Measurement; Pain Threshold; Reaction Time; Staining and Labeling; Time Factors; TRPV Cation Channels | 2005 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Edema; Electroshock; Etodolac; Fluoxetine; Gastric Acid; Gastric Mucosa; Hot Temperature; Hypericum; Indomethacin; Pain; Peritonitis; Plant Extracts; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Stomach Ulcer | 2005 |
Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Capsaicin; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Neurons, Afferent; Nociceptors; Pain; Phosphorylation; Rats; Rats, Sprague-Dawley; Threonine; Trigeminal Ganglion; TRPV Cation Channels | 2005 |
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Antibodies; Behavior, Animal; Blotting, Western; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Chelating Agents; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Guanethidine; Indoles; Male; Mice; Nociceptors; Pain; Pain Measurement; Peptide Fragments; Propranolol; Protein Kinase C; Ruthenium Red; Salicylates; Sympatholytics; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Opponent appetitive-aversive neural processes underlie predictive learning of pain relief.
Topics: Avoidance Learning; Behavior Therapy; Brain; Capsaicin; Conditioning, Psychological; Female; Functional Laterality; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Models, Biological; Oxygen; Pain; Pain Management; Pain Measurement; Reward; Statistics, Nonparametric; Time Factors | 2005 |
Mechanism by which peripheral galanin increases acute inflammatory pain.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Functional Laterality; Galanin; Inflammation; Male; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Time Factors | 2005 |
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Hindlimb; Hyperalgesia; Indans; Male; Pain; Rats; Rats, Sprague-Dawley | 2005 |
Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain.
Topics: Adenosine Triphosphate; Animals; Calcium; Capsaicin; Cell Line; Dose-Response Relationship, Drug; Hyperalgesia; Ion Channels; Mice; Neurons; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; TRPV Cation Channels | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area Under Curve; Blotting, Western; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Pain; Pain Measurement; Phosphorylation; Physical Stimulation; Protein Kinase C; Rats; Receptors, AMPA; Serine; Spider Venoms; Spinal Cord | 2005 |
Protein kinases mediate increment of the phosphorylation of cyclic AMP-responsive element binding protein in spinal cord of rats following capsaicin injection.
Topics: Animals; Capsaicin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pain; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Rats, Sprague-Dawley; Spinal Cord | 2005 |
The effects of chemical or surgical deafferentation on [3H]-acetylcholine release from rat spinal cord.
Topics: Acetylcholine; Afferent Pathways; Animals; Capsaicin; Cholinergic Agents; Enzyme Inhibitors; Hemicholinium 3; Ligation; Male; Organ Culture Techniques; Pain; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord; Spinal Nerves | 2005 |
A human experimental capsaicin model for trigeminal sensitization. Gender-specific differences.
Topics: Capsaicin; Female; Forehead; Humans; Injections, Intradermal; Luteal Phase; Male; Menstrual Cycle; Migraine Disorders; Models, Biological; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Sex Distribution; Sex Factors; Skin; Trigeminal Nerve | 2005 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Histamine; Histidine Decarboxylase; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Histamine H1; Receptors, Neurokinin-1; Substance P; Time Factors | 2005 |
TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Capsaicin; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Pain; Pain Measurement; TRPV Cation Channels | 2005 |
Development of highly potent and selective dynorphin A analogues as new medicines.
Topics: Animals; Biological Assay; Brain; Capsaicin; Drug Design; Dynorphins; Guinea Pigs; Ileum; Ligands; Macaca mulatta; Mice; Muscle, Smooth; Opioid Peptides; Pain; Peptides; Protein Conformation; Receptors, Cell Surface; Species Specificity | 2005 |
Differential inhibitory effects of mu-opioids on substance P- and capsaicin-induced nociceptive behavior in mice.
Topics: Analgesics, Opioid; Animals; Capsaicin; Male; Mice; Narcotics; Pain; Pain Measurement; Receptors, Opioid, mu; Substance P | 2006 |
Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice.
Topics: Analgesics; Analysis of Variance; Animals; Bone Neoplasms; Capsaicin; Cell Line; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Freund's Adjuvant; Functional Laterality; Inflammation; Mice; Mice, Inbred C3H; Osteosarcoma; Pain; Pain Measurement; Reaction Time; Time Factors | 2006 |
Tonic, phasic, and integrator components of psychophysical responses to topical capsaicin account for differences of location and sex.
Topics: Afferent Pathways; Ankle; Capsaicin; Drug Resistance; Female; Humans; Inflammation Mediators; Male; Models, Neurological; Mouth; Neural Conduction; Nociceptors; Pain; Pain Threshold; Pain, Intractable; Psychophysics; Sensory Receptor Cells; Sex Characteristics; Skin | 2005 |
Influence of sensory deprivation and perturbation of trigeminal afferent fibers on corticomotor control of human tongue musculature.
Topics: Adult; Afferent Pathways; Anesthetics, Local; Capsaicin; Efferent Pathways; Electromyography; Evoked Potentials, Motor; Female; Humans; Hypoglossal Nerve; Lingual Nerve; Male; Motor Cortex; Motor Neurons; Muscle, Skeletal; Nociceptors; Pain; Sensory Deprivation; Sensory Receptor Cells; Tongue; Transcranial Magnetic Stimulation; Trigeminal Nerve | 2006 |
Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis.
Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Capsaicin; Male; Neurons, Afferent; Pain; Pain Measurement; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord; Spinal Nerves; Substance P; TRPV Cation Channels | 2006 |
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; Glutamic Acid; Male; Mice; Motor Activity; Nitric Oxide; Pain; Pain Measurement; Plant Extracts; Psychomotor Performance; Reaction Time; Serotonin; Triterpenes | 2006 |
Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Inflammation Mediators; Male; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels | 2006 |
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamic Acid; Hot Temperature; Male; Morphine; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid; Sensory Receptor Cells; Signal Transduction | 2006 |
Impaired pain sensation in mice lacking Aquaporin-1 water channels.
Topics: Animals; Aquaporin 1; Capsaicin; Choroid Plexus; Ganglia, Spinal; Hot Temperature; Mice; Mice, Knockout; Pain; Pain Threshold; Posterior Horn Cells; Signal Transduction | 2006 |
[Effects of bradykinin and capsaicin intramuscular injections on stretch-evoked postsynaptic response of motoneurones of the gastrocnemius-soleus muscle].
Topics: Animals; Bradykinin; Capsaicin; Cats; Excitatory Postsynaptic Potentials; Injections, Intramuscular; Male; Motor Neurons; Muscle Spindles; Muscle, Skeletal; Pain | 2005 |
Gender differences in pain and secondary hyperalgesia after heat/capsaicin sensitization in healthy volunteers.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Reference Values; Sex Factors | 2006 |
Bis selenide alkene derivatives: A class of potential antioxidant and antinociceptive agents.
Topics: Alkenes; Analgesics; Animals; Antioxidants; Capsaicin; Dithiothreitol; Glutathione; Lipid Peroxidation; Male; Narcotic Antagonists; Oxidoreductases Acting on Sulfur Group Donors; Pain; Rats; Rats, Wistar; Selenium | 2006 |
Protein phosphatase 2A regulates central sensitization in the spinal cord of rats following intradermal injection of capsaicin.
Topics: Animals; Behavior, Animal; Capsaicin; Humans; Male; Models, Biological; Models, Neurological; Nociceptors; Pain; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinal Cord | 2006 |
Analgesic activity of a non-peptide imidazolidinedione somatostatin agonist: in vitro and in vivo studies in rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Binding, Competitive; Bradykinin; Capsaicin; Colforsin; Drug Interactions; Formaldehyde; Hot Temperature; Imidazolidines; In Vitro Techniques; Inflammation; Male; Nerve Fibers; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Somatostatin; Thionucleotides | 2006 |
The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization.
Topics: Adult; Botulinum Toxins, Type A; Capsaicin; Face; Forehead; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain; Pain Measurement; Pain Threshold; Pressure; Regional Blood Flow; Skin Temperature; Trigeminal Nerve; Urticaria | 2006 |
Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test.
Topics: Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Electric Stimulation; Foot; Hindlimb; Male; Mice; Nerve Fibers, Unmyelinated; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Predictive Value of Tests; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Nerve Roots; Substance P; Synaptic Transmission | 2006 |
Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin.
Topics: Animals; Boron Compounds; Bradykinin; Capsaicin; Cells, Cultured; Cyclooxygenase 2; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Inositol 1,4,5-Trisphosphate; MAP Kinase Kinase 1; MAP Kinase Signaling System; Neurons; Pain; Potassium; Potassium Chloride; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptor, Bradykinin B2; Signal Transduction; Substance P; Type C Phospholipases | 2006 |
GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat.
Topics: Action Potentials; Animals; Bicuculline; Capsaicin; Electrophysiology; Female; GABA Antagonists; GABA-A Receptor Antagonists; Male; Mustard Plant; Neurons; Nociceptors; Pain; Physical Stimulation; Picrotoxin; Plant Oils; Posterior Horn Cells; Rats; Rats, Wistar; Stimulation, Chemical | 2006 |
Neurochemical changes in the RVM associated with peripheral inflammatory pain stimuli.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Capsaicin; Chromatography, High Pressure Liquid; Dinoprostone; Drug Interactions; Electrochemistry; Hot Temperature; Male; Medulla Oblongata; Microdialysis; Morphine; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time | 2006 |
Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors.
Topics: Animals; Behavior, Animal; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Endothelin-1; Injections, Subcutaneous; Male; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Endothelin A; Touch; TRPV Cation Channels | 2006 |
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior.
Topics: Animals; Behavior, Animal; Body Temperature; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Gastrointestinal Hormones; Gene Expression Regulation; Hyperalgesia; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; TRPV Cation Channels | 2006 |
Bee venom injection significantly reduces nociceptive behavior in the mouse formalin test via capsaicin-insensitive afferents.
Topics: Acupuncture Analgesia; Acupuncture Points; Afferent Pathways; Analgesics; Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Diterpenes; Drug Resistance; Locus Coeruleus; Male; Mice; Mice, Inbred ICR; Neurons, Afferent; Neurotoxins; Nociceptors; Norepinephrine; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Receptors, Adrenergic, alpha-2; Spinal Cord; Tyrosine 3-Monooxygenase | 2006 |
Capsaicin-evoked brain activation and central sensitization in anaesthetised rats: a functional magnetic resonance imaging study.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Capsaicin; Hyperalgesia; Injections, Intradermal; Magnetic Resonance Imaging; Mesencephalon; Ointments; Oxygen; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Sprague-Dawley; Skin; Superior Colliculi; Thalamus; Time Factors | 2006 |
The effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin.
Topics: Afferent Pathways; Alkenes; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Inflammation Mediators; Male; Nociceptors; Okadaic Acid; Pain; Pain Threshold; Phosphoprotein Phosphatases; Physical Stimulation; Polyenes; Posterior Horn Cells; Pyrones; Rats; Rats, Sprague-Dawley; Reaction Time; Synaptic Transmission; Time Factors | 2006 |
Differential responses of rostral subnucleus caudalis and upper cervical dorsal horn neurons to mechanical and chemical stimulation of the parotid gland in rats.
Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Cervical Vertebrae; Cold Temperature; Hyperalgesia; Inflammation Mediators; Male; Nociceptors; Pain; Pain Measurement; Pain Threshold; Parotid Gland; Parotitis; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Skin; Trigeminal Caudal Nucleus | 2006 |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Capsaicin; Coloring Agents; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; KATP Channels; Lamiaceae; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Oleanolic Acid; Pain; Pain Measurement; Postural Balance; Potassium Channels, Inwardly Rectifying; Ruthenium Red; Yohimbine | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats.
Topics: Animals; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Injections, Intradermal; Male; Neurons; Pain; Pregnenolone; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Cold Temperature; Electrophysiology; Hot Temperature; Mice; Mice, Knockout; Mustard Plant; Pain; Pain Threshold; Physical Stimulation; Plant Oils; Posterior Horn Cells; Skin; Spinal Cord; TRPV Cation Channels | 2006 |
Important factors for pain during photodynamic therapy for actinic keratosis.
Topics: Aged; Aged, 80 and over; Capsaicin; Color; Female; Humans; Keratosis; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Photochemotherapy; Photosensitivity Disorders | 2006 |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Cultured; Central Nervous System; Disease Models, Animal; Humans; Hyperalgesia; Indazoles; Inflammation Mediators; Injections, Spinal; Male; Nociceptors; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Sulfones; Treatment Outcome; TRPV Cation Channels; Urea | 2006 |
Intradermal capsaicin causes dose-dependent pain, allodynia, and hyperalgesia in humans.
Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Female; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Aged; Pain | 2006 |
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo.
Topics: Animals; Base Sequence; Capsaicin; Chlorocebus aethiops; Colitis; COS Cells; Disease Models, Animal; Humans; Male; Mice; Molecular Sequence Data; Nervous System Diseases; Pain; Pyrazines; Pyridines; Rats; RNA Interference; Sequence Alignment; Sequence Homology, Amino Acid; TRPV Cation Channels | 2006 |
Mechanisms involved in the antinociception caused by melatonin in mice.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Male; Melatonin; Mice; Pain | 2006 |
TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.
Topics: Alternative Splicing; Analgesics, Non-Narcotic; Animals; Capsaicin; Cell Line; Down-Regulation; Exons; Ganglia, Spinal; Gene Expression Profiling; Hot Temperature; Humans; Hydrogen-Ion Concentration; Macromolecular Substances; Male; Molecular Sequence Data; Nervous System; Neurons; Nociceptors; Pain; Protein Isoforms; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Thermosensing; TRPV Cation Channels | 2006 |
Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Capsaicin; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Glycine; Inflammation; Ion Channels; Male; Mice; Mice, Inbred ICR; Nociceptors; Oocytes; Pain; Patch-Clamp Techniques; Rats; Rats, Wistar; Sensory Receptor Cells; TRPV Cation Channels; Xenopus | 2006 |
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.
Topics: Animals; Binding, Competitive; Calcium; Capsaicin; Cell Line; Cell Membrane; Diterpenes; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Hydrogen-Ion Concentration; Linoleic Acid; Male; Membrane Fluidity; Membrane Potentials; Mice; Mice, Inbred C57BL; Oocytes; Pain; Rats; RNA, Complementary; TRPV Cation Channels; Xenopus laevis | 2007 |
A role for adrenomedullin as a pain-related peptide in the rat.
Topics: Adrenomedullin; Animals; Behavior, Animal; Binding Sites; Calcitonin Gene-Related Peptide; Capsaicin; Enzyme Activation; Ganglia, Spinal; Inflammation; Injections, Spinal; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Nociceptors; Pain; Phosphotransferases; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Proteins; Receptors, Adrenomedullin; Receptors, Peptide; Signal Transduction | 2006 |
TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Autonomic Pathways; Capsaicin; Cardiovascular Physiological Phenomena; Diterpenes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Periaqueductal Gray; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels | 2007 |
Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Capsaicin; Enzyme Activation; Exploratory Behavior; Ganglia, Spinal; Immunohistochemistry; Injections, Intradermal; Male; Motor Activity; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Peripheral Nervous System; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2007 |
Impaired pain sensation in mice lacking prokineticin 2.
Topics: Animals; Behavior, Animal; Capsaicin; Ganglia, Spinal; Gastrointestinal Hormones; Hypesthesia; In Situ Hybridization; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuropeptides; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Stimulation, Chemical; TRPV Cation Channels | 2006 |
Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate.
Topics: Afferent Pathways; Animals; Capsaicin; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Interneurons; Male; Neural Inhibition; Nociceptors; Organ Culture Techniques; Pain; Pertussis Toxin; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Spinal Nerve Roots; Synaptic Transmission | 2007 |
Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action.
Topics: Acetic Acid; Analgesics; Animals; Benzene Derivatives; Bradykinin; Capsaicin; Edema; Female; Glutamates; Hindlimb; Hot Temperature; Lethal Dose 50; Male; Mice; Organoselenium Compounds; Pain | 2007 |
Caged capsaicins: New tools for the examination of TRPV1 channels in somatosensory neurons.
Topics: Animals; Benzyl Compounds; Biochemistry; Capsaicin; Cell Membrane; Cells, Cultured; Humans; Kinetics; Ligands; Models, Chemical; Neurons; Pain; Protein Transport; Rats; TRPV Cation Channels; Ultraviolet Rays | 2007 |
The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
Topics: Administration, Oral; Animals; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabis; Capsaicin; Chronic Disease; Dinoprostone; Freund's Adjuvant; Hyperalgesia; Inflammation; Lipid Peroxides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Sciatic Neuropathy; Tumor Necrosis Factor-alpha | 2007 |
Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice.
Topics: Animals; Anticonvulsants; Capsaicin; Carbamates; Colon; KCNQ2 Potassium Channel; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Pain Threshold; Phenylenediamines; Reaction Time; Sensory Receptor Cells; Visceral Afferents | 2007 |
Sex differences in the potency of kappa opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation; Injections, Intraventricular; Injections, Subcutaneous; Male; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Inbred F344; Receptors, Opioid; Sex Factors | 2007 |
Mouse colon sensory neurons detect extracellular acidosis via TRPV1.
Topics: Acidosis; Amiloride; Animals; Capsaicin; Cell Size; Cells, Cultured; Colon; Evoked Potentials; Extracellular Fluid; Ganglia, Spinal; Hydrogen-Ion Concentration; Kinetics; Lumbosacral Plexus; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pain; Patch-Clamp Techniques; Sodium Channel Blockers; Thoracic Nerves; TRPV Cation Channels | 2007 |
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
Topics: Acetic Acid; Age Factors; Anilides; Animals; Animals, Newborn; Capsaicin; Catheterization; Cinnamates; Colon; Disease Models, Animal; Diterpenes; Electromyography; Ganglia, Spinal; Hyperalgesia; Irritable Bowel Syndrome; Male; Pain; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; TRPV Cation Channels; Visceral Afferents | 2007 |
Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain.
Topics: Animals; Capsaicin; Disease Models, Animal; Hyperalgesia; Male; Pain; Pain Threshold; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2007 |
Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae).
Topics: Analgesics; Animals; Apomorphine; Atropine; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Morphine; Naloxone; Nitroarginine; Pain; Pain Measurement; Plant Extracts; Rosaceae; Saponins; Yohimbine | 2006 |
Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse.
Topics: Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Coculture Techniques; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Glutamine; Indoles; Maleimides; Neuronal Plasticity; Neurons, Afferent; Pain; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphorylation; Posterior Horn Cells; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels; Type C Phospholipases | 2007 |
A feedback-controlled dynamic linear actuator to test foot withdrawal thresholds in rat.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Feedback; Foot; Functional Laterality; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Probability; Rats; Rats, Wistar; Reaction Time; Skin; Time Factors | 2007 |
Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain.
Topics: Adult; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Humans; Hyperalgesia; Inflammation Mediators; Laser-Doppler Flowmetry; Male; Middle Aged; Models, Neurological; Nerve Fibers, Unmyelinated; Neuronal Plasticity; Neurosecretory Systems; Nociceptors; Pain; Pain Measurement; Psychophysics; Regional Blood Flow; Sensory Receptor Cells; Skin; Time Factors | 2007 |
Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function.
Topics: Animals; Capsaicin; Cervix Uteri; Dilatation, Pathologic; Estrogens; Female; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2007 |
Inward currents induced by ischemia in rat spinal cord dorsal horn neurons.
Topics: Age Factors; Animals; Animals, Newborn; Capsaicin; Electric Stimulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ischemia; Organ Culture Techniques; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.
Topics: Animals; Arachidonic Acids; Capsaicin; Endocannabinoids; Immunohistochemistry; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord; TRPV Cation Channels | 2007 |
Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channels; Calcium Radioisotopes; Calcium Signaling; Capsaicin; Female; Flavonoids; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Injections, Intraventricular; Injections, Spinal; Interleukin-1beta; Ion Channel Gating; Male; Mice; Pain; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Substance P; Tumor Necrosis Factor-alpha | 2007 |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Topics: Action Potentials; Analgesics; Aniline Compounds; Animals; Capsaicin; Evoked Potentials; Furans; Ganglia, Spinal; Humans; Inflammation; Kinetics; Male; Mononeuropathies; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sodium Channel Blockers; Sodium Channels | 2007 |
Antinociceptive effect and interaction of uncompetitive and competitive NMDA receptor antagonists upon capsaicin and paw pressure testing in normal and monoarthritic rats.
Topics: Analgesics; Animals; Arthritis, Experimental; Binding, Competitive; Capsaicin; Drug Interactions; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Injections, Spinal; Pain; Pain Measurement; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vocalization, Animal | 2008 |
Potassium- and capsaicin-induced release of agmatine from spinal nerve terminals.
Topics: Afferent Pathways; Agmatine; Animals; Capsaicin; Male; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission; Synaptic Vesicles; Synaptosomes | 2007 |
Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Behavior, Animal; Blotting, Western; Capsaicin; Citrates; Immunohistochemistry; Injections, Spinal; Ligation; Male; Microglia; Minocycline; Neuroglia; Pain; Pain Measurement; Phenols; Physical Stimulation; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Sciatic Nerve; Spinal Cord | 2007 |
Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients.
Topics: Adult; Capsaicin; Electroencephalography; Evoked Potentials; Face; Female; Hand; Humans; Lasers; Male; Migraine without Aura; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Skin; Stimulation, Chemical; Trigeminal Nerve | 2007 |
Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Calcium; Calmodulin; Capsaicin; Cells, Cultured; Chemotherapy, Adjuvant; Chlorpromazine; Enzyme Inhibitors; Fibroblasts; Humans; Imidazoles; Ion Channel Gating; Keratinocytes; Male; Membrane Potentials; Mice; Models, Molecular; Neurons; NIH 3T3 Cells; Pain; Rats; Rats, Wistar; Sensory System Agents; TRPV Cation Channels | 2007 |
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors.
Topics: Afferent Pathways; Animals; Ankyrins; Calcineurin; Calcitonin Gene-Related Peptide; Calcium Channels; Calcium Signaling; Capsaicin; Irritants; Male; Mustard Plant; Neurons, Afferent; Nociceptors; Pain; Plant Oils; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2008 |
Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine.
Topics: Area Under Curve; Blinking; Capsaicin; Chronic Disease; Electric Stimulation; Electrophysiology; Hand; Humans; Irritants; Migraine Disorders; Nociceptors; Pain; Reflex, Abnormal | 2007 |
Dual regulation of TRPV1 by phosphoinositides.
Topics: Animals; Calcium Signaling; Capsaicin; Cell Line; Cell Membrane; Enzyme Inhibitors; Hot Temperature; Humans; Neurons, Afferent; Nociceptors; Oocytes; Pain; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Rats; TRPV Cation Channels; Type C Phospholipases; Xenopus laevis | 2007 |
Spinal mechanisms of antinociceptive action caused by diphenyl diselenide.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzene Derivatives; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Inhibitory Concentration 50; Interleukin-1beta; Male; Mice; Organoselenium Compounds; Pain; Pain Measurement; Spinal Cord; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
Topics: Analgesics, Non-Narcotic; Animals; Benzothiazoles; Body Temperature; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Drug Administration Schedule; Drug Design; Female; Fever; Freund's Adjuvant; Macaca fascicularis; Male; Molecular Structure; Pain; Pyrimidines; Rats; Rats, Sprague-Dawley; Telemetry; TRPV Cation Channels | 2007 |
Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Colitis; Colon; Dextran Sulfate; Female; Hyperalgesia; Mice; Mice, Inbred C57BL; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Spinal Cord; TRPV Cation Channels | 2007 |
Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.
Topics: Animals; Behavior, Animal; Capsaicin; Cell Count; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Ganglia, Spinal; Male; Membrane Potentials; Mice; Mice, Knockout; Neurons, Afferent; Pain; Pain Measurement; Patch-Clamp Techniques; Peripheral Nervous System Diseases; Physical Stimulation; Platelet Membrane Glycoproteins; Reaction Time; Receptors, G-Protein-Coupled | 2007 |
Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential.
Topics: Animals; Botulinum Toxins; Bradykinin; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Exocytosis; Membrane Potentials; Mice; Neurons, Afferent; Nociceptors; Pain; Potassium; Protein Isoforms; R-SNARE Proteins; Rats; SNARE Proteins; Substance P; Synaptic Vesicles; Synaptosomal-Associated Protein 25; Syntaxin 1; Trigeminal Ganglion | 2007 |
Electrophysiological properties and chemosensitivity of acutely dissociated trigeminal somata innervating the cornea.
Topics: Action Potentials; Animals; Capsaicin; Cells, Cultured; Cornea; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Ophthalmic Nerve; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Trigeminal Ganglion | 2007 |
Neuroscience: a local route to pain relief.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Capsaicin; Cell Membrane Permeability; Electric Conductivity; Humans; Lidocaine; Nociceptors; Pain; Sodium; Sodium Channel Blockers; TRPV Cation Channels | 2007 |
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Capsaicin; Cell Membrane Permeability; Electric Conductivity; Ganglia, Spinal; Lidocaine; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Sodium; Sodium Channel Blockers; TRPV Cation Channels | 2007 |
Chillies: out of the frying pan and into the clinic?
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Capsaicin; Drug Interactions; Humans; Lidocaine; Pain; Rats; TRPV Cation Channels | 2007 |
Antinociceptive activity of petroleum ether fraction from the MeOH extracts of Paederia scandens in mice.
Topics: Acetic Acid; Alkanes; Analgesics; Animals; Capsaicin; Formaldehyde; Hot Temperature; Methanol; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pentobarbital; Phytotherapy; Plant Extracts; Rubiaceae; Sleep | 2008 |
Site-specific, dose-dependent, and sex-related responses to the experimental pain model induced by intradermal injection of capsaicin to the foreheads and forearms of healthy humans.
Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Epidemiologic Methods; Facial Pain; Female; Forearm; Forehead; Humans; Injections, Intradermal; Male; Models, Theoretical; Pain; Sensory System Agents; Sex Factors; Time Factors; Trigeminal Nerve | 2007 |
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetic Acid; Analgesics; Animals; Benzene Derivatives; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Edema; Enzyme Activators; Excitatory Amino Acids; Female; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Immersion; Injections, Spinal; Mice; Motor Activity; Organoselenium Compounds; Pain; Reaction Time; Signal Transduction | 2008 |
Modulation of intracellular calcium influences capsaicin-induced currents of TRPV-1 and voltage-activated channel currents in nociceptive neurones.
Topics: Animals; Calcium; Calcium Channels; Capsaicin; Intracellular Fluid; Neurons, Afferent; Pain; Rats; Rats, Inbred Lew; Rats, Wistar; TRPV Cation Channels | 2007 |
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.
Topics: Action Potentials; Animals; Brain Stem; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Male; Microdialysis; Microinjections; Neural Pathways; Neurons, Efferent; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Sensory System Agents; TRPV Cation Channels | 2007 |
Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn.
Topics: Animals; Capsaicin; Glycine; Inhibitory Postsynaptic Potentials; Male; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 2008 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenzenes; Formaldehyde; Ganglia, Spinal; Hot Temperature; Inflammation; Male; Mice; Neurons; Organ Specificity; Pain; Protein Isoforms; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Triazoles | 2008 |
Modulation of acute visceral nociception and bladder inflammation by plant triterpene, alpha, beta-amyrin in a mouse model of cystitis: role of tachykinin NK(1)-receptors, and K(+)(ATP) channels.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cyclophosphamide; Cystitis; Edema; Glyburide; KATP Channels; Male; Mice; Oleanolic Acid; Pain; Receptors, Neurokinin-1; TRPV Cation Channels; Urinary Bladder | 2007 |
Regions of interest analysis in pharmacological fMRI: how do the definition criteria influence the inferred result?
Topics: Adult; Amines; Analgesics; Brain; Capsaicin; Cyclohexanecarboxylic Acids; Echo-Planar Imaging; Gabapentin; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Models, Statistical; Oxygen; Pain | 2008 |
Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.
Topics: Animals; Calcium; Capsaicin; Cell Line; Gene Expression Regulation; Humans; Ion Channel Gating; Ion Transport; Membrane Potentials; Mice; Mice, Knockout; Nociceptors; Pain; Protein Structure, Secondary; Protons; Sensory System Agents; Sodium; Swine; TRPV Cation Channels | 2008 |
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Topics: Acids; Animals; Capsaicin; Hyperalgesia; Inflammation; Mole Rats; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells | 2008 |
Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.
Topics: Animals; Cannabinoids; Capsaicin; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Neurons, Afferent; Pain; Pain Measurement; Plant Oils; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2008 |
Adlea (ALGRX-4975), an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief.
Topics: Analgesics; Animals; Capsaicin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Injections; Neuralgia; Pain; Pain, Postoperative; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; TRPV Cation Channels | 2008 |
Pronociceptive response elicited by TRPA1 receptor activation in mice.
Topics: Analgesics; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Isothiocyanates; Male; Mice; Pain; Pain Measurement; Ruthenium Red; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2008 |
Dissociable neural activity to self- vs. externally administered thermal hyperalgesia: a parametric fMRI study.
Topics: Adaptation, Psychological; Adult; Brain; Brain Mapping; Capsaicin; Cerebral Cortex; Chronic Disease; Cognition; Data Interpretation, Statistical; Functional Laterality; Gyrus Cinguli; Hot Temperature; Humans; Hyperalgesia; Limbic System; Magnetic Resonance Imaging; Male; Neurons; Neuropsychological Tests; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Self Administration; Somatosensory Cortex | 2008 |
Inhibitory effect of cochinchinenin B on capsaicin-activated responses in rat dorsal root ganglion neurons.
Topics: Analgesics; Animals; Binding Sites; Binding, Competitive; Capsaicin; Cells, Cultured; Chalcone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Ganglia, Spinal; Male; Membrane Potentials; Molecular Structure; Neural Inhibition; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensory System Agents; TRPV Cation Channels | 2008 |
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2.
Topics: Animals; Capsaicin; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Messenger; Sensory Receptor Cells; TRPV Cation Channels; Uridine Triphosphate | 2008 |
Inflammation-induced increase in evoked calcium transients in subpopulations of rat dorsal root ganglion neurons.
Topics: Action Potentials; Animals; Calcium; Calcium Signaling; Capsaicin; Cell Size; Cells, Cultured; Fura-2; Ganglia, Spinal; Inflammation; Male; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Plant Lectins; Potassium; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2008 |
TRPV1 shows dynamic ionic selectivity during agonist stimulation.
Topics: Animals; Binding Sites; Capsaicin; Cell Line; Cell Membrane Permeability; Cells, Cultured; Humans; Inflammation Mediators; Ion Channel Gating; Ions; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Sensory System Agents; Synaptic Transmission; Time Factors; TRPV Cation Channels | 2008 |
The capsaicin-blink reflex linkage in chronic migraine revisited.
Topics: Area Under Curve; Blinking; Capsaicin; Chronic Disease; Electric Stimulation; Electrophysiology; Hand; Humans; Irritants; Migraine Disorders; Nociceptors; Pain; Reflex, Abnormal | 2008 |
Fire in the hole: pore dilation of the capsaicin receptor TRPV1.
Topics: Animals; Capsaicin; Cell Membrane Permeability; Humans; Hyperalgesia; Inflammation Mediators; Ion Channel Gating; Ions; Models, Molecular; Neurogenic Inflammation; Nociceptors; Pain; Sensory Receptor Cells; Sensory System Agents; Signal Transduction; TRPV Cation Channels | 2008 |
Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Foot Diseases; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Neoplasms, Experimental; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Inbred F344; Ruthenium Red; TRPV Cation Channels | 2008 |
Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Arachidonic Acids; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Coculture Techniques; Dopamine; Ganglia, Spinal; Glutamic Acid; Mitochondria; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Synaptic Transmission; TRPV Cation Channels | 2008 |
Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.
Topics: Administration, Topical; Analgesia; Analgesics; Animals; Barium; Calcium; Calmodulin; Capsaicin; Humans; Ion Channel Gating; Membrane Potentials; Models, Molecular; Pain; Rats; TRPV Cation Channels | 2008 |
Effects of neonatal capsaicin administration on the nociceptive response of the rat to mechanical and chemical stimuli.
Topics: Animals; Animals, Newborn; Capsaicin; Fatty Acids, Unsaturated; Female; Pain; Rats | 1980 |
Effects of neonatal capsaicin treatment on nociceptive thresholds in the rat.
Topics: Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Neurons, Afferent; Neurotransmitter Agents; Pain; Rats; Sensory Thresholds | 1983 |
Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.
Topics: Afferent Pathways; Animals; Capsaicin; Cats; Injections, Spinal; Morphine; Nociceptors; Pain; Potassium; Rats; Spinal Cord; Substance P | 1980 |
A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Glutamate Decarboxylase; Male; Pain; Rats; Somatostatin; Spinal Cord; Substance P | 1981 |
Vascular and sensory responses of human skin to mild injury after topical treatment with capsaicin.
Topics: Administration, Topical; Axons; Capsaicin; Differential Threshold; Fatty Acids, Unsaturated; Humans; Pain; Reflex; Sensation; Skin; Substance P; Vasodilation | 1981 |
Characterization in guinea pigs of the sensory effects of the putative substance P neurotoxin capsaicin.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Guinea Pigs; Male; Morphine; Pain; Sensory Receptor Cells; Somatostatin; Substance P | 1981 |
Sensory and motor functions of spinal cord substance P.
Topics: Animals; Capsaicin; Mice; Motor Activity; Pain; Receptors, Cell Surface; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Skin; Spinal Cord; Substance P | 1981 |
Capsaicin and nociception in the rat and mouse. Possible role of substance P.
Topics: Animals; Behavior, Animal; Capsaicin; Eye; Fatty Acids, Unsaturated; Female; Hindlimb; Injections, Spinal; Male; Mice; Nociceptors; Pain; Rats; Rats, Inbred Strains; Species Specificity; Substance P; Thermoreceptors | 1982 |
Substance P reduces tail-flick latency: implications for chronic pain syndromes.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Cell Surface; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1982 |
Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells.
Topics: Animals; Animals, Newborn; Bradykinin; Capsaicin; Cell Differentiation; Cells, Cultured; Dinoprostone; Ganglia, Spinal; Neurons; Pain; Prostaglandins E; Rats; Substance P; Trigeminal Nerve | 1983 |
Pharmacological studies on the application, disposition, and release of neurotensin in the spinal cord.
Topics: Animals; Capsaicin; Cats; Histocytochemistry; Kainic Acid; Neurotensin; Nociceptors; Pain; Radioimmunoassay; Reaction Time; Spinal Cord; Spinal Nerve Roots; Substance P; Tissue Distribution | 1982 |
Respiratory effects of intrathecal capsaicin in arthritic and non-arthritic rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Body Weight; Capsaicin; Injections, Spinal; Male; Pain; Rats; Rats, Inbred Strains; Respiration; Substance P | 1984 |
Action of intrathecal capsaicin and its structural analogues on the content and release of spinal substance P: selectivity of action and relationship to analgesia.
Topics: Animals; Capsaicin; Cholecystokinin; Homovanillic Acid; Injections, Spinal; Male; Pain; Phenylacetates; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Tachyphylaxis; Vasoactive Intestinal Peptide | 1984 |
Effects of cysteamine on pain behaviour and on somatostatin- and substance P-like immunoreactivity in the substantia gelatinosa of the rat.
Topics: Animals; Capsaicin; Cysteamine; Histocytochemistry; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Substance P; Substantia Gelatinosa | 1984 |
Biphasic time-course of capsaicin-induced substance P depletion: failure to correlate with thermal analgesia in the rat.
Topics: Animals; Capsaicin; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Substance P | 1984 |
Antinociceptive effects of neonatal capsaicin in rats with adjuvant arthritis.
Topics: Analgesics; Animals; Animals, Newborn; Arthritis; Arthritis, Experimental; Body Weight; Capsaicin; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds | 1984 |
Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea.
Topics: Alkaloids; Animals; Benzodioxoles; Capsaicin; Denervation; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Muscle, Smooth; Neuromuscular Junction; Pain; Piperidines; Polyunsaturated Alkamides; Tetrodotoxin; Trachea | 1983 |
Capsaicin treatment and stress-induced analgesia.
Topics: Analgesia; Animals; Capsaicin; Cold Temperature; Deoxyglucose; Dose-Response Relationship, Drug; Electroshock; Fatty Acids, Unsaturated; Humans; Male; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Stress, Psychological; Swimming | 1983 |
The effects of a series of capsaicin analogues on nociception and body temperature in the rat.
Topics: Animals; Body Temperature; Capsaicin; Female; Male; Nociceptors; Pain; Rats; Sensory Thresholds; Structure-Activity Relationship | 1984 |
Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests.
Topics: Analgesia; Animals; Capsaicin; Formaldehyde; Male; Morphine; Pain; Peripheral Nerves; Rats; Sciatic Nerve; Time Factors | 1984 |
Analgesia induced by neonatal capsaicin treatment in rats.
Topics: Animals; Animals, Newborn; Capsaicin; Chemoreceptor Cells; Fatty Acids, Unsaturated; Hot Temperature; Nociceptors; Pain; Pressure; Rats; Rats, Inbred Strains; Reaction Time | 1982 |
Visceral pain reflex after pretreatment with capsaicin and morphine.
Topics: Anesthetics, Local; Animals; Blood Pressure; Capsaicin; Electric Stimulation; Fatty Acids, Unsaturated; Female; Male; Morphine; Muscle Contraction; Neurons, Afferent; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Vagotomy | 1982 |
Effects of single doses of capsaicin on nociceptive thresholds in the rodent.
Topics: Acetylcholine; Animals; Capsaicin; Fatty Acids, Unsaturated; Formaldehyde; Hot Temperature; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain | 1981 |
Neonatal capsaicin and thermal nociception: a paradox.
Topics: Animals; Animals, Newborn; Blood Pressure; Capsaicin; Fatty Acids, Unsaturated; Gastrointestinal Motility; Hot Temperature; Nociceptors; Pain; Rats; Skin Physiological Phenomena | 1981 |
Effect of capsaicin on morphine analgesia--possible involvement of hypothalamic structures.
Topics: Animals; Animals, Newborn; Capsaicin; Fatty Acids, Unsaturated; Female; Hypothalamus; In Vitro Techniques; Male; Morphine; Pain; Rats | 1980 |
The non-peptide NK1 receptor antagonist SR140333 produces long-lasting inhibition of neurogenic inflammation, but does not influence acute chemo- or thermonociception in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Capillary Permeability; Capsaicin; Dinoprostone; Female; Hot Temperature; Injections, Intravenous; Injections, Subcutaneous; Male; Motor Activity; Nerve Tissue; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley | 1995 |
Sensory denervation with capsaicin attenuates inflammation and nociception in arthritic rats.
Topics: Animals; Arthritis; Capsaicin; Inflammation; Male; Nociceptors; Pain; Rats; Rats, Wistar; Sensory Thresholds; Time Factors | 1995 |
The non-peptide neurokinin-1 antagonist, RPR 100893, decreases c-fos expression in trigeminal nucleus caudalis following noxious chemical meningeal stimulation.
Topics: Animals; Blood Proteins; Capsaicin; Guinea Pigs; Indoles; Isoindoles; Male; Meninges; Neurokinin-1 Receptor Antagonists; Pain; Proto-Oncogene Proteins c-fos; Substance P; Trigeminal Nuclei | 1995 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylphenethylamine; Pain; Pruritus; Substance P | 1995 |
Noxious peripheral stimulation produces antinociception mediated via substance P and opioid mechanisms in the rat tail-flick test.
Topics: Animals; Capsaicin; Endorphins; Hindlimb; Hot Temperature; Immersion; Male; Naloxone; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Substance P | 1995 |
Nicotinic acetylcholine receptors on capsaicin-sensitive nerves.
Topics: Afferent Pathways; Animals; Capsaicin; Cerebral Cortex; Electric Stimulation; Female; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord | 1995 |
Central versus peripheral site of action of the tachykinin NK1-antagonist RP 67580 in inhibiting chemonociception.
Topics: Analgesics; Animals; Blood Pressure; Blood-Brain Barrier; Capsaicin; Female; Hydrochloric Acid; Indoles; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1995 |
The 21st Meeting of the British Inflammation Research Society, "Inflammatory pain", King's College, London, 19th December, 1994.
Topics: Arthritis, Experimental; Asthma; Bronchial Hyperreactivity; Capsaicin; Humans; Inflammation; Nerve Growth Factors; Neurons, Afferent; Nitric Oxide Synthase; Pain; Receptors, Bradykinin; Spinal Cord; Up-Regulation | 1995 |
The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Immunoglobulin G; Inflammation; Nerve Growth Factors; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Recombinant Fusion Proteins | 1995 |
Effects of topical capsaicin in seasonal allergic rhinitis.
Topics: Administration, Topical; Adult; Allergens; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Capillary Permeability; Capsaicin; Female; Histamine; Humans; Male; Middle Aged; Nasal Mucosa; Pain; Pollen; Rhinitis, Allergic, Seasonal; Time Factors | 1995 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Pain Measurement; Postural Balance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Desensitizing mechanism of capsaicin and nonanoyl vanillylamide on the vascular nociceptive response in the guinea pig.
Topics: Acetylcholine; Animals; Bradykinin; Capsaicin; Ganglia, Spinal; Guinea Pigs; Injections, Intra-Arterial; Injections, Spinal; Injections, Subcutaneous; Male; Pain; Spinal Cord; Substance P; Vanillic Acid; Vocalization, Animal | 1993 |
The amino-terminus of substance P mimics and MK-801 attenuates the effects of capsaicin on nociception and kainic acid-induced behavior in the mouse.
Topics: Analysis of Variance; Animals; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; Pain; Peptide Fragments; Piperazines; Receptors, N-Methyl-D-Aspartate; Substance P | 1993 |
Effect of CP-96,345 a non-peptide substance P antagonist, capsaicin, resiniferatoxin and ruthenium red on nociception.
Topics: Action Potentials; Analgesics; Animals; Biphenyl Compounds; Capsaicin; Diterpenes; Hot Temperature; Injections, Spinal; Pain; Peripheral Nerves; Rats; Ruthenium Red; Spinal Cord; Spinal Nerve Roots; Stereoisomerism; Substance P | 1993 |
Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.
Topics: Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Mice; Naloxone; Pain; Substance P | 1993 |
The analgesia induced by intrathecal injection of ruthenium red.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain; Pain Measurement; Ruthenium Red; Substance P | 1993 |
Capsaicin in treatment of loin pain/haematuria syndrome.
Topics: Adult; Capsaicin; Female; Hematuria; Humans; Kidney; Middle Aged; Pain | 1995 |
Pain and hyperalgesia in acute inflammatory and chronic neuropathic conditions.
Topics: Acute Disease; Capsaicin; Chronic Disease; Humans; Neuralgia; Pain | 1995 |
Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat.
Topics: Animals; Capsaicin; Hot Temperature; Male; Mechanoreceptors; Nerve Fibers; Nerve Growth Factors; Pain; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Spinal Nerves; Sympathectomy; Sympathetic Fibers, Postganglionic | 1995 |
Capsaicin-induced central facilitation of a sympathetic vasoconstrictor response to painful stimulation in humans.
Topics: Adult; Blood Flow Velocity; Capsaicin; Electric Stimulation; Ethanol; Female; Humans; Male; Nociceptors; Pain; Vagus Nerve; Vasoconstriction | 1994 |
Assessment of cutaneous sensory and autonomic axon reflexes in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Axons; Capsaicin; Forearm; Humans; Middle Aged; Pain; Reflex; Regional Blood Flow; Skin; Sweating; Vasodilation; Wrist | 1995 |
Stimulation of cyclic GMP production via a nitrosyl factor in sensory neuronal cultures by algesic or inflammatory agents.
Topics: Animals; Bradykinin; Capsaicin; Cells, Cultured; Cyclic GMP; Ganglia, Spinal; Inflammation Mediators; Lipopolysaccharides; Neurons, Afferent; Nitro Compounds; Pain; Rats; Rats, Sprague-Dawley | 1995 |
Critical role of the capsaicin-sensitive nerve fibers in the development of the causalgic symptoms produced by transecting some but not all of the nerves innervating the rat tail.
Topics: Animals; Capsaicin; Hot Temperature; Male; Nerve Fibers; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Nerves; Tail; Time Factors | 1995 |
Capsaicin and the cause of causalgia.
Topics: Capsaicin; Causalgia; Humans; Neuropeptides; Pain; Skin Temperature | 1995 |
Responses of lateral thalamic neurons to algesic chemical stimulation of the cat knee joint.
Topics: Afferent Pathways; Animals; Bradykinin; Brain Mapping; Capsaicin; Cats; Electric Stimulation; Hindlimb; Joints; Nerve Fibers; Neurons; Pain; Potassium Chloride; Thalamus; Time Factors | 1994 |
Peppering pain.
Topics: Animals; Capsaicin; Humans; Pain; Rats | 1993 |
Treatment of PUVA-induced skin pain with capsaicin.
Topics: Adult; Capsaicin; Female; Humans; Pain; PUVA Therapy; Skin Diseases | 1994 |
Heal the burn: pepper and lasers in cancer pain therapy.
Topics: Capsaicin; Humans; Laser Therapy; Pain | 1994 |
Different patterns of hyperalgesia induced by experimental inflammation in human skin.
Topics: Adult; Capsaicin; Dermatitis; Female; Freezing; Humans; Hyperalgesia; Male; Middle Aged; Pain; Physical Stimulation; Sensation; Sensory Thresholds; Skin | 1994 |
Reduction of capsaicin-induced ocular pain and neurogenic inflammation by calcium antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Capsaicin; Cornea; Diltiazem; Dose-Response Relationship, Drug; Keratitis; Neuritis; Nifedipine; Nociceptors; Pain; Rabbits; Verapamil | 1993 |
Capsaicin did not evoke pain from human hand vein segments but did so after injections into the paravascular tissue.
Topics: Capsaicin; Fat Emulsions, Intravenous; Fingers; Humans; Injections; Injections, Intradermal; Injections, Intravenous; Male; Nerve Fibers; Nociceptors; Pain; Regional Blood Flow; Skin | 1993 |
Capsaicin applied to rat lumbar intervertebral disc causes extravasation in the groin skin: a possible mechanism of referred pain of the intervertebral disc.
Topics: Animals; Capsaicin; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Groin; Lumbar Vertebrae; Male; Nerve Fibers; Pain; Rats; Rats, Sprague-Dawley; Skin; Spinal Diseases; Spinal Nerves | 1993 |
Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans.
Topics: Administration, Topical; Adult; Capsaicin; Electric Stimulation; Electrophysiology; Female; H-Reflex; Humans; Male; Middle Aged; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Sural Nerve | 1993 |
Topical capsaicin in treatment of hyperalgesia, allodynia and dysesthetic pain caused by malignant tumour infiltration of the skin.
Topics: Administration, Topical; Adult; Capsaicin; Humans; Hyperalgesia; Male; Pain; Skin Neoplasms | 1993 |
Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract.
Topics: Administration, Intravesical; Adult; Aged; Capsaicin; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pain; Sensation Disorders; Urinary Bladder Diseases; Urination | 1993 |
Modulation of voltage-activated Ca currents by pain-inducing agents in a dorsal root ganglion neuronal line, F-11.
Topics: Action Potentials; Animals; Bradykinin; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Line; Diterpenes; Electrophysiology; Ganglia, Spinal; Mice; Neurons; omega-Conotoxins; Pain; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetrodotoxin | 1993 |
Osteoarthritis treatment update. Minimizing pain while limiting patient risk.
Topics: Acetaminophen; Administration, Topical; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Humans; Injections, Intra-Articular; Osteoarthritis; Pain; Physical Therapy Modalities; Risk Factors | 1993 |
Cutaneous pretreatment with the capsaicin analog NE-21610 prevents the pain to a burn and subsequent hyperalgesia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Burns; Capsaicin; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Pain; Pain Measurement; Physical Stimulation; Skin | 1995 |
[Therapeutic trials with topical capsaicin cream and iontophoretically applied lidocaine for diabetic painful truncal neuropathy].
Topics: Capsaicin; Diabetic Neuropathies; Humans; Hyperesthesia; Iontophoresis; Lidocaine; Male; Middle Aged; Ointments; Pain | 1996 |
Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Arginine; Capsaicin; Clonidine; Male; Mice; Nitroarginine; Pain; Phenylephrine; Plant Extracts; Prazosin; Yohimbine | 1995 |
Brief, prolonged and repeated stimuli applied to hyperalgesic skin areas: a psychophysical study.
Topics: Capsaicin; Electric Stimulation; Hot Temperature; Humans; Hyperalgesia; Lasers; Pain; Pain Threshold; Psychophysics; Skin | 1996 |
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity | 1996 |
Sodium nonivamide acetate: a non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties.
Topics: Animals; Bradykinin; Capsaicin; Dermatologic Agents; Dinoprostone; Humans; Mice; Pain; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Wistar; Tail; Thromboxane B2; Thromboxane-A Synthase | 1996 |
Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord.
Topics: Acetic Acid; Animals; Capsaicin; Female; Immunohistochemistry; Neurons, Afferent; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord; Urinary Bladder | 1996 |
Responses of adult human dorsal root ganglion neurons in culture to capsaicin and low pH.
Topics: Action Potentials; Adult; Back Pain; Capsaicin; Cell Size; Cells, Cultured; Electrophysiology; Female; Ganglia, Spinal; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Neural Conduction; Neuralgia; Neurofibromatoses; Neurons; Pain; Patch-Clamp Techniques; Scoliosis | 1996 |
Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism.
Topics: Adult; Capsaicin; Humans; Hyperalgesia; Middle Aged; Nerve Block; Nerve Fibers; Pain; Spinal Cord | 1996 |
The use of pharmacologic pain sensitization in the treatment of repetitive hair-pulling.
Topics: Adult; Aversive Therapy; Behavior Therapy; Capsaicin; Female; Humans; Irritants; Pain; Trichotillomania | 1996 |
Strychnine-sensitive modulation is selective for non-noxious somatosensory input in the spinal cord of the rat.
Topics: Anesthesia, General; Animals; Animals, Newborn; Blood Pressure; Capsaicin; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Nerve Fibers; Pain; Physical Stimulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine | 1996 |
Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat.
Topics: Animals; Capsaicin; Cold Temperature; Electric Stimulation; Functional Laterality; Hindlimb; Lidocaine; Male; Nerve Fibers; Neurons, Afferent; Pain; Peripheral Nervous System Diseases; Rats; Rats, Inbred Lew; Regional Blood Flow; Sciatic Nerve; Skin; Spinal Cord; Time Factors; Ultrasonography, Doppler; Vasoconstriction; Vasodilation | 1996 |
Peripherally administrated morphine attenuates capsaicin-induced mechanical hypersensitivity in humans.
Topics: Adult; Aged; Capsaicin; Female; Humans; Male; Mechanoreceptors; Middle Aged; Morphine; Pain; Peripheral Nervous System; Receptors, Opioid; Time Factors | 1997 |
Excitatory effects of algesic compounds on neuronal processes in murine dorsal root ganglion cell culture.
Topics: Action Potentials; Animals; Bradykinin; Capsaicin; Cells, Cultured; Dinoprostone; Ganglia, Spinal; Mice; Neurons; Pain; Patch-Clamp Techniques; Tetrodotoxin | 1997 |
Comment: capsaicin for pain relief in Guillain-Barré syndrome.
Topics: Adult; Analgesics; Capsaicin; Female; Humans; Pain; Polyradiculoneuropathy | 1997 |
Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P.
Topics: Animals; Behavior, Animal; Capsaicin; Decerebrate State; Hot Temperature; Male; Nociceptors; Pain; Radioimmunoassay; Rats; Rats, Wistar; Skin; Spinal Cord; Substance P | 1997 |
The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Glycerol; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tachyphylaxis; Taste; Trigeminal Ganglion | 1997 |
The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test.
Topics: Afferent Pathways; Animals; Behavior, Animal; Blood Pressure; Capsaicin; Female; Heart Rate; Immunohistochemistry; Male; Nerve Tissue Proteins; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Chemical sensory deafferentation abolishes hypothalamic pituitary activation induced by noxious stimulation or electroacupuncture but only decreases that caused by immobilization stress. A c-fos study.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Chemoreceptor Cells; Denervation; Electroacupuncture; Hypothalamo-Hypophyseal System; Immobilization; Pain; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stress, Physiological | 1997 |
Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Capsaicin; Hyperalgesia; Injections, Intradermal; Male; Microdialysis; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Pain; Pain Threshold; Peptides; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spider Venoms | 1997 |
The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.
Topics: Animals; Behavior, Animal; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; GTP-Binding Proteins; Injections, Intradermal; Male; Microdialysis; Pain; Pain Measurement; Physical Stimulation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice.
Topics: Animals; Capsaicin; Drug Evaluation, Preclinical; Injections, Spinal; Male; Mice; Pain; Perfusion; Spinal Cord; Substance P | 1997 |
Antinociception induced by civamide, an orally active capsaicin analogue.
Topics: Administration, Oral; Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Hot Temperature; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P | 1997 |
Neonatal capsaicin treatment abolishes formalin-induced spinal PGE2 release.
Topics: Amino Acids; Animals; Animals, Newborn; Capsaicin; Dinoprostone; Formaldehyde; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; Colic; Dose-Response Relationship, Drug; Indomethacin; Male; Morphine; Pain; Peritoneum; Prostaglandins; Pyrrolidines; Rats; Rats, Sprague-Dawley; Viscera | 1997 |
Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence.
Topics: Administration, Cutaneous; Analgesics, Opioid; Analysis of Variance; Animals; Capsaicin; Female; Hot Temperature; Morphine; Nerve Fibers; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Skin Temperature | 1996 |
Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats.
Topics: Abdomen; Acetic Acid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colon; Humans; Male; Muscle Contraction; Muscle, Smooth; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rectum | 1997 |
Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis.
Topics: Adult; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Forearm; Histamine; Humans; Inflammation; Iontophoresis; Microdialysis; Pain; Skin; Substance P; Time Factors | 1997 |
Capsaicin-evoked mechanical allodynia and hyperalgesia cross-nerve territories.
Topics: Capsaicin; Humans; Hyperalgesia; Pain; Pharmaceutical Vehicles | 1997 |
Differential effects of noxious conditioning stimulation of the cheek by capsaicin on human sensory and inhibitory masseter reflex responses evoked by tooth pulp stimulation.
Topics: Administration, Cutaneous; Adult; Bite Force; Capsaicin; Cheek; Dental Pulp; Dextromethorphan; Differential Threshold; Dose-Response Relationship, Drug; Double-Blind Method; Electric Stimulation; Evoked Potentials; Humans; Irritants; Male; Masseter Muscle; Middle Aged; Muscle Contraction; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reflex; Sensation; Skin | 1997 |
Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.
Topics: Animals; Capsaicin; Cyclic AMP-Dependent Protein Kinase RIbeta Subunit; Cyclic AMP-Dependent Protein Kinases; Differential Threshold; Dinoprostone; Gene Expression; Gene Targeting; Hot Temperature; Isoenzymes; Mice; Mice, Mutant Strains; Mutation; Neuritis; Nociceptors; Pain; Sciatic Nerve; Sensory Thresholds; Transgenes; Wounds, Nonpenetrating | 1997 |
Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Drug Interactions; Formaldehyde; Injections, Intradermal; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Pain; Receptors, Tachykinin | 1997 |
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Topics: Animals; Capsaicin; Cell Membrane; Cells, Cultured; Fluorescent Antibody Technique; Hyperalgesia; Immunotoxins; Injections, Spinal; N-Glycosyl Hydrolases; Neurons; Pain; Pain Management; Pain Measurement; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P | 1997 |
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Hypesthesia; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Nerve Growth Factors; Neurotrophin 3; Organophosphorus Compounds; Pain; Pain Threshold; Perfusion; Pressure; Rats; Rats, Wistar; Secretory Rate; Single-Blind Method; Spinal Cord; Substance P | 1997 |
Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias (Polygalaceae).
Topics: Abdominal Pain; Acetic Acid; Analgesia; Analgesics; Animals; Aspirin; Bradykinin; Capsaicin; Ethanol; Hot Temperature; Male; Pain; Pain Measurement; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Substance P; Water; Xanthenes; Xanthones | 1997 |
NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Functional Laterality; Hindlimb; Injections, Spinal; Kynurenic Acid; Male; Medulla Oblongata; Neuronal Plasticity; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Trigeminal Nerve | 1997 |
Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intradermal; Injections, Intraventricular; Male; Mice; Naloxone; Pain; Ruthenium Red | 1997 |
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
[Molecular biology of pain. Cloning of a temperature sensitive pain receptor].
Topics: Capsaicin; Cloning, Molecular; DNA, Recombinant; Humans; Nociceptors; Pain | 1997 |
Chillies: from antiquity to urology.
Topics: Capsaicin; Capsicum; History, 18th Century; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; Humans; Pain; Pain Management; Phytotherapy; Plants, Medicinal; Urologic Diseases | 1997 |
Global cerebral blood flow decreases during pain.
Topics: Adult; Blood Flow Velocity; Brain; Capsaicin; Carbon Dioxide; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Middle Aged; Oxygen; Pain; Tomography, Emission-Computed; Vibration | 1998 |
Sites of renal pain processing in the rat spinal cord. A c-fos study using a percutaneous method to perform ureteral obstruction.
Topics: Animals; Capsaicin; Cell Count; Denervation; Disease Models, Animal; Female; Immunohistochemistry; Kidney; Neurons, Afferent; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord; Ureteral Obstruction | 1997 |
The treatment of periocular and facial pain with topical capsaicin.
Topics: Administration, Topical; Aged; Capsaicin; Eye Diseases; Facial Pain; Female; Humans; Male; Middle Aged; Ointments; Pain; Trigeminal Neuralgia | 1998 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord | 1998 |
Topical capsaicin as an adjuvant analgesic for the treatment of traumatic amputee neurogenic residual limb pain.
Topics: Adult; Amputation, Surgical; Capsaicin; Disarticulation; Hand; Humans; Male; Middle Aged; Pain; Phantom Limb; Wounds, Nonpenetrating | 1998 |
The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
Topics: Animals; Azocines; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hot Temperature; Macaca mulatta; Male; Naltrexone; Pain; Receptors, Opioid, mu | 1998 |
Enhancing effect of dimethyl sulfoxide on nociceptive transmission in isolated spinal cord of newborn rat.
Topics: Animals; Animals, Newborn; Capsaicin; Cholinesterases; Dimethyl Sulfoxide; Electric Stimulation; Excitatory Postsynaptic Potentials; Humans; Infant, Newborn; Nerve Fibers; Neurons, Afferent; Nociceptors; Osmotic Pressure; Pain; Potassium Channel Blockers; Rats; Rats, Wistar; Reflex; Spinal Cord; Spinal Nerve Roots; Substance P | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase Inhibitors; Diclofenac; Formaldehyde; Inflammation; Male; Meloxicam; Mice; Morphine; Muscle Contraction; Pain; Pain Measurement; Reaction Time; Thiazines; Thiazoles | 1998 |
Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents.
Topics: Afferent Pathways; Animals; Brain Stem; Capsaicin; Female; Gastric Acid; Gastric Mucosa; Genes, fos; Hydrochloric Acid; Instillation, Drug; Morphine; Naloxone; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Spinal Cord; Transcription, Genetic; Vagus Nerve | 1998 |
Differential effect of painful heterotopic stimulation on capsaicin-induced pain and allodynia.
Topics: Adult; Capsaicin; Cold Temperature; Differential Threshold; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Models, Neurological; Pain; Pain Measurement; Physical Stimulation; Spinal Cord; Time Factors | 1998 |
Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice.
Topics: Acids; Animals; Blinking; Capsaicin; Cornea; Female; Hot Temperature; Male; Mice; Mice, Knockout; Neurons, Afferent; Nociceptors; Noxae; Pain; Peripheral Nerves; Physical Stimulation; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Stimulation, Chemical | 1998 |
The cloned capsaicin receptor integrates multiple pain-producing stimuli.
Topics: Afferent Pathways; Amino Acid Sequence; Animals; Capsaicin; Cell Line; Cloning, Molecular; Ganglia, Spinal; Hot Temperature; Humans; Immunohistochemistry; Male; Membrane Potentials; Models, Neurological; Molecular Sequence Data; Nerve Fibers; Neurogenic Inflammation; Neurons, Afferent; Oocytes; Pain; Patch-Clamp Techniques; Peptide Fragments; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Drug; Recombinant Proteins; Sciatic Nerve; Spinal Cord; Superior Cervical Ganglion; Transfection; Xenopus laevis | 1998 |
[Chemical anatomy of the nociceptive transmission and modulation in the spinal dorsal horn].
Topics: Animals; Capsaicin; Cats; Glutamates; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Wistar; Spinal Cord; Substance P | 1996 |
Hot peppers and pain.
Topics: Animals; Capsaicin; Humans; Neurons, Afferent; Nociceptors; Pain; Receptors, Drug; Spinal Cord | 1998 |
Swimming capacity of mice is increased by oral administration of a nonpungent capsaicin analog, stearoyl vanillylamide.
Topics: Animals; Blood Glucose; Capsaicin; Epinephrine; Fatty Acids, Nonesterified; Injections, Intravenous; Male; Mice; Pain; Physical Exertion; Substance P; Swimming | 1998 |
Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Glycopeptides; Hindlimb; Hydroxymercuribenzoates; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pain; Protease Inhibitors; Receptors, Opioid; Time Factors | 1998 |
The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Capsaicin; Extracellular Space; Guaiacol; Neurons, Afferent; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Tachyphylaxis; Taste; Trigeminal Ganglion | 1998 |
A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance.
Topics: Animals; Capsaicin; Carrageenan; Functional Laterality; Hindlimb; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Spinal Cord | 1998 |
The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Capsaicin; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Excipients; Hindlimb; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Nociceptors; Oxytocics; Pain; Pain Threshold; Rats; Rats, Wistar; Thionucleotides; Ultraviolet Rays | 1999 |
Dynamic mechanical allodynia in humans is not mediated by a central presynaptic interaction of A beta-mechanoreceptive and nociceptive C-afferents.
Topics: Adult; Capsaicin; Central Nervous System; Humans; Laser-Doppler Flowmetry; Mechanoreceptors; Middle Aged; Nerve Fibers; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Receptors, Presynaptic; Regional Blood Flow; Skin; Transcutaneous Electric Nerve Stimulation | 1999 |
Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats.
Topics: Animals; Capsaicin; Diterpenes; Hyperalgesia; Ligation; Male; Neurons, Afferent; Pain; Pain Measurement; Peripheral Nervous System; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Time Factors | 1999 |
Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation.
Topics: Adult; Body Temperature; Capsaicin; Female; Humans; Hyperalgesia; Male; Pain; Regional Blood Flow; Skin; Sympathetic Nervous System; Vasodilation | 1999 |
Intraluminal capsaicin does not affect fluid and electrolyte absorption in the human jejunum but does cause pain.
Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Electrolytes; Humans; Intestinal Absorption; Jejunum; Male; Neurons, Afferent; Pain; Water | 1998 |
Somatotopic activation of opioid systems by target-directed expectations of analgesia.
Topics: Analgesia; Analysis of Variance; Anesthetics, Local; Capsaicin; Double-Blind Method; Foot; Functional Laterality; Hand; Humans; Infusions, Intravenous; Injections, Subcutaneous; Naloxone; Pain; Pain Threshold; Placebo Effect | 1999 |
Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice.
Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain | 1999 |
Involvement of primary afferent C-fibres in touch-evoked pain (allodynia) induced by prostaglandin E2.
Topics: Afferent Pathways; Animals; Capsaicin; Dinoprostone; Electrophysiology; Hot Temperature; Hyperesthesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Nerve Fibers; Neurons; Pain; Physical Stimulation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1999 |
Jaw electromyographic activity induced by the application of algesic chemicals to the rat tooth pulp.
Topics: Animals; Bradykinin; Capsaicin; Dental Pulp; Electromyography; Evans Blue; Inflammation; Jaw; Male; Masseter Muscle; Mustard Plant; Naloxone; Narcotic Antagonists; Neutrophils; Pain; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley | 1999 |
Pain creams: can you find relief in a tube?
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Humans; Irritants; Liniments; Ointments; Pain; Palliative Care; Pharmacopoeias, Homeopathic as Topic; Salicylates | 1998 |
The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Capsaicin; Hot Temperature; Hyperalgesia; Male; Morpholines; Motor Activity; Naphthalenes; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1999 |
Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation.
Topics: Administration, Topical; Adult; Aged; Capsaicin; Cold Temperature; Epidermis; Female; Hot Temperature; Humans; Male; Middle Aged; Nerve Fibers; Pain; Physical Stimulation; Reference Values; Skin; Thiolester Hydrolases; Touch; Ubiquitin Thiolesterase | 1999 |
Neurokinin-1 receptors are involved in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia in mice.
Topics: Animals; Capsaicin; Hot Temperature; Hyperalgesia; Mice; Mice, Inbred BALB C; Mice, Knockout; Pain; Reaction Time; Receptors, Neurokinin-1 | 1999 |
Low dose of kyotorphin (tyrosine-arginine) induces nociceptive responses through a substance P release from nociceptor endings.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Endorphins; Male; Mice; Mice, Inbred Strains; Nerve Endings; Neurokinin-1 Receptor Antagonists; Pain; Substance P | 1999 |
Immortalized human dorsal root ganglion cells differentiate into neurons with nociceptive properties.
Topics: Action Potentials; Capsaicin; Cations; Cell Differentiation; Cell Line; Cell Lineage; Cell Size; Clone Cells; Ganglia, Spinal; Genes, myc; Humans; Ion Channel Gating; Ligands; Neurons, Afferent; Nociceptors; Pain; Stem Cells; Tetracycline; Transcription Factors | 1999 |
Rat peripheral nerve components release calcitonin gene-related peptide and prostaglandin E2 in response to noxious stimuli: evidence that nervi nervorum are nociceptors.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Dinoprostone; Electric Stimulation; Inflammation Mediators; Male; Nociceptors; Pain; Peripheral Nerves; Rats; Rats, Wistar; Ruthenium Red; Stimulation, Chemical | 1999 |
Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice.
Topics: Analysis of Variance; Animals; Capsaicin; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred ICR; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Spinal Cord | 1999 |
Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells.
Topics: Animals; Capsaicin; Chromones; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Macaca fascicularis; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Neural Pathways; Nociceptors; Pain; Physical Stimulation; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Skin; Spinal Cord; Thalamus | 1999 |
The generalizability of capsaicin sensitization and desensitization.
Topics: Adult; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Female; Habituation, Psychophysiologic; Humans; Irritants; Male; Mouth; Pain; Pain Threshold; Psychophysics; Taste; Taste Threshold; Time Factors | 1999 |
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Age-related changes in the response to thermal noxious heat and reduction of C-fibers by neonatal treatment with capsaicin.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Female; Hot Temperature; Infrared Rays; Male; Mice; Nerve Fibers; Nociceptors; Pain; Pain Measurement; Rats; Spinal Nerve Roots | 1999 |
Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study.
Topics: Adult; Brain; Capsaicin; Female; Humans; Hyperalgesia; Magnetic Resonance Imaging; Male; Pain; Pain Measurement | 1999 |
Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception.
Topics: Animals; Avoidance Learning; Caenorhabditis elegans; Capsaicin; Hot Temperature; Models, Neurological; Motor Activity; Movement; Mutation; Neurotransmitter Agents; Pain; Reflex | 1999 |
Tourniquet constriction exacerbates hyperalgesia-related pain induced by intradermal capsaicin injection.
Topics: Administration, Cutaneous; Adult; Capillaries; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Regional Blood Flow; Skin; Tourniquets | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Carrageenan; Dinoprostone; Dipeptides; Dose-Response Relationship, Drug; Edema; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Pain; Rats; Rats, Wistar; Receptor, Bradykinin B2; Time Factors | 1999 |
Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Nerve Growth Factor; Nerve Growth Factors; Neurons, Afferent; Neuroprotective Agents; Neurotrophin 3; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor, trkA; Stimulation, Chemical; Tachyphylaxis | 1999 |
Sex differences in cholinergic analgesia II: differing mechanisms in two models of allodynia.
Topics: Analgesics; Animals; Capsaicin; Cholinergic Agents; Female; Injections, Spinal; Ligation; Male; Muscarinic Agonists; Muscarinic Antagonists; Neostigmine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sex Factors; Spinal Nerves | 1999 |
Effects of GABA receptor antagonist on trigeminal caudalis nociceptive neurons in normal and neonatally capsaicin-treated rats.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Brain Mapping; Capsaicin; Functional Laterality; GABA Antagonists; GABA-A Receptor Antagonists; Male; Medulla Oblongata; Microinjections; Neuronal Plasticity; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Touch; Trigeminal Nerve | 1999 |
Neural and endocrine mechanisms mediating noxious stimulus-induced inhibition of bradykinin plasma extravasation in the rat.
Topics: Adrenal Glands; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Electric Stimulation; Endocrine Glands; Hypophysectomy; Knee Joint; Male; Mifepristone; Naloxone; Narcotic Antagonists; Nervous System Physiological Phenomena; Neurons, Afferent; Pain; Phentolamine; Propranolol; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sympathetic Nervous System; Synovial Fluid | 1999 |
Immunohistochemical localization of choline acetyltransferase of a peripheral type in the rat larynx.
Topics: Afferent Pathways; Animals; Capsaicin; Choline O-Acetyltransferase; Denervation; Efferent Pathways; Immunoenzyme Techniques; Immunohistochemistry; Laryngeal Muscles; Laryngeal Nerves; Larynx; Male; Medulla Oblongata; Nerve Fibers; Pain; Rats; Rats, Wistar; Vagotomy; Viscera | 1999 |
Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.
Topics: Animals; Capsaicin; Enzyme Activation; Formaldehyde; Hindlimb; In Vitro Techniques; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nociceptors; Pain; Pain Measurement; Pain Threshold; Phosphorylation; Posterior Horn Cells; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Temperature | 1999 |
Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia.
Topics: Action Potentials; Adenosine; Analgesics; Animals; Bradykinin; Capsaicin; Carbocyanines; Colon; Dinoprostone; Dose-Response Relationship, Drug; Electrophysiology; Fluorescent Dyes; Ganglia, Spinal; Histamine; Ion Channel Gating; Male; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Serotonin; Sodium; Sodium Channels; Tetrodotoxin | 1999 |
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Male; Mice; Motor Activity; Nociceptors; Pain; Pain Measurement; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Spinal Cord | 1999 |
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Local; Animals; Azocines; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
No effect of sympathetic sudomotor activity on capsaicin-evoked ongoing pain and hyperalgesia.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Pain; Physical Stimulation; Skin; Skin Temperature; Sweat Glands; Sympathetic Nervous System | 2000 |
Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain.
Topics: Adult; Capsaicin; Female; Humans; Injections, Intradermal; Injections, Intramuscular; Male; Muscle, Skeletal; Pain; Pain Measurement; Pain Threshold; Pressure; Skin | 2000 |
Effect of zaldaride maleate, an antidiarrheal compound, on visceral pain reflex induced by small intestinal distention in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Animals, Newborn; Antidiarrheals; Atropine; Benzimidazoles; Blood Pressure; Capsaicin; Intestines; Male; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Papaverine; Pentobarbital; Phentolamine; Rats; Rats, Sprague-Dawley; Reflex; Vasodilator Agents | 1999 |
Early experience of intra-ureteric capsaicin infusion in loin pain haematuria syndrome.
Topics: Administration, Topical; Adult; Algorithms; Capsaicin; Female; Hematuria; Humans; Male; Middle Aged; Pain; Patient Selection; Syndrome; Treatment Outcome | 2000 |
Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres.
Topics: Adult; Capsaicin; Electric Stimulation; Electrophysiology; Female; Hot Temperature; Humans; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Pain; Reaction Time; Skin; Stimulation, Chemical | 2000 |
Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Bradykinin; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Mice, Knockout; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Pain; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substance P | 2000 |
Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice.
Topics: Animals; Behavior, Animal; Capsaicin; Chlorpheniramine; Formaldehyde; Histamine H1 Antagonists; Hot Temperature; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrilamine; Reaction Time; Receptors, Histamine H1; Reverse Transcriptase Polymerase Chain Reaction; Stereoisomerism | 2000 |
The effect of neonatal capsaicin on the c-Fos-like immunoreactivity induced in subnucleus oralis neurons by noxious intraoral stimulation.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Electric Stimulation; Female; Formaldehyde; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; Male; Mouth Mucosa; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion | 2000 |
Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis.
Topics: Acetic Acid; Anesthetics, Intravenous; Animals; Capsaicin; Choline O-Acetyltransferase; Chronic Disease; Cyclophosphamide; Cystitis, Interstitial; Female; Immunosuppressive Agents; Indicators and Reagents; Male; Nerve Fibers; Nociceptors; Pain; Parasympathetic Nervous System; Physical Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sodium Chloride; Spinal Cord; Stimulation, Chemical; Therapeutic Irrigation; Urethane; Urinary Bladder | 2000 |
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Topics: Animals; Body Temperature; Calcium; Capsaicin; Cells, Cultured; Diterpenes; Ganglia, Spinal; Gene Targeting; Hot Temperature; Hydrogen-Ion Concentration; Inflammation; Mice; Mice, Knockout; Nerve Fibers; Neurons; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Receptors, Drug; Spinal Cord; TRPV Cation Channels | 2000 |
Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Capsaicin; Consciousness; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Knockout; Morphine; Nerve Fibers; Nociceptin; Nociceptors; Opioid Peptides; Pain; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Substance P; Time Factors; Vasodilator Agents | 2000 |
Hot pepper receptor could help manage pain.
Topics: Animals; Capsaicin; Hot Temperature; Mice; Mice, Knockout; Neurons, Afferent; Nociceptors; Pain; Receptors, Drug; TRPV Cation Channels | 2000 |
[Topical administration of capsaicin in dermatology for treatment of itching and pain].
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Biopsy; Capsaicin; Female; Humans; Male; Microscopy, Confocal; Microscopy, Electron; Middle Aged; Pain; Pruritus; Skin; Skin Diseases; Time Factors | 2000 |
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Carrageenan; Cells, Cultured; Electrophysiology; Endocannabinoids; Female; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Targeting; Hot Temperature; Hydrogen-Ion Concentration; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Pain; Polyunsaturated Alkamides; Receptors, Drug; Stem Cells; TRPV Cation Channels | 2000 |
ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.
Topics: Adenosine Triphosphate; Adult; Capsaicin; Drug Synergism; Female; Humans; Hyperalgesia; Iontophoresis; Male; Neurons, Afferent; Nociceptors; Pain; Regional Blood Flow; Skin; Touch; Ultraviolet Rays | 2000 |
Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Brazil; Capsaicin; Diterpenes; Female; Formaldehyde; Male; Medicine, Traditional; Mice; Pain; Plants, Medicinal | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Receptors, Neurokinin-1; Substance P; Urinary Bladder; Visceral Afferents | 2000 |
Toward a new anti-inflammatory and analgesic agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin Receptor Antagonists; Capsaicin; Cyclooxygenase 2; Formaldehyde; Inflammation; Interleukin-1; Isoenzymes; Mice; Mice, Knockout; Pain; Prostaglandin-Endoperoxide Synthases; Receptor, Bradykinin B1; Receptors, Bradykinin; Receptors, Neurokinin-1; Shock, Septic | 2000 |
Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo.
Topics: Animals; Calcium; Capsaicin; Cell Communication; Electric Stimulation; Guinea Pigs; Inflammation; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Substance P; Trigeminal Ganglion | 2000 |
Inhibition of motor unit firing during experimental muscle pain in humans.
Topics: Action Potentials; Adult; Capsaicin; Electromyography; Female; Humans; Isometric Contraction; Jaw; Male; Masseter Muscle; Motor Neurons; Neural Inhibition; Pain; Pain Measurement; Pain Threshold | 2000 |
Cross-desensitization of capsaicin-evoked oral irritation by high but not low concentrations of nicotine in human subjects.
Topics: Adult; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Nicotine; Nociceptors; Pain; Tongue | 2000 |
Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Capsaicin; Diuresis; Dynorphins; Female; Injections, Intramuscular; Injections, Subcutaneous; Macaca mulatta; Male; Pain; Pain Measurement; Reaction Time; Receptors, Opioid, kappa | 2000 |
[Analgesic test using neonatal rat: quantification of algesic substance-induced body movement].
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Capsaicin; Dose-Response Relationship, Drug; Movement; Pain; Pain Measurement; Rats; Receptors, Opioid, mu | 2000 |
Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior.
Topics: Analgesics; Animals; Capsaicin; Ginsenosides; Hindlimb; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Panax; Phytotherapy; Plants, Medicinal; Saponins | 2000 |
Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae).
Topics: Abdomen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Brazil; Capsaicin; Euphorbiaceae; Formaldehyde; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Plant Extracts; Plants, Medicinal | 2000 |
Too hot to handle--an unusual location for an adverse effect of capsaicin.
Topics: Administration, Topical; Aged; Capsaicin; Fingers; Hand Disinfection; Humans; Male; Pain; Paresthesia; Penis | 2000 |
[The effect of anti-NGF and NGF on the responses to noxious heat in mice treated with capsaicin in the neonatal period].
Topics: Animals; Animals, Newborn; Capsaicin; Hot Temperature; Mice; Mice, Inbred Strains; Nerve Fibers; Nerve Growth Factor; Nerve Regeneration; Pain; Reaction Time; Spinal Nerve Roots; Time Factors | 2000 |
Arginine-rich peptides are blockers of VR-1 channels with analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Arginine; Capsaicin; Dynorphins; Electric Conductivity; Eye; Inhibitory Concentration 50; Mice; Oocytes; Pain; Peptides; Receptors, Drug; TRPV Cation Channels; Xenopus laevis | 2000 |
Antinociceptive activity of a hydroalcoholic extract obtained from aerial parts of Sebastiania schottiana (Euphorbiaceae).
Topics: Acetates; Analgesics; Animals; Capsaicin; Euphorbiaceae; Formaldehyde; Mice; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Plant Stems | 2000 |
Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Analgesics, Opioid; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Mice; Morphine; Neurons, Afferent; Neuroprotective Agents; Oligopeptides; Pain; Pertussis Toxin; Piperidines; Protease Inhibitors; Purinergic Agonists; Thionucleosides; Time Factors; Virulence Factors, Bordetella | 2000 |
Subclassified acutely dissociated cells of rat DRG: histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cluster Analysis; Ganglia, Spinal; Lectins; Male; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Protons; Rats; Rats, Sprague-Dawley; Substance P | 2000 |
Re: Early experience of intraureteric capsaicin infusion in loin-pain haematuria syndrome.
Topics: Capsaicin; Hematuria; Humans; Pain; Syndrome | 2000 |
Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells.
Topics: Action Potentials; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Evoked Potentials; Lumbosacral Region; Macaca fascicularis; Male; Microdialysis; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Metabotropic Glutamate; Skin; Spinothalamic Tracts; Thalamic Nuclei | 2000 |
In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue.
Topics: Analgesics; Animals; Behavior, Animal; Blinking; Blood Pressure; Bronchoconstriction; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Eye; Female; Ganglia, Spinal; Guinea Pigs; Hindlimb; Hyperalgesia; Irritants; Male; Mice; Mice, Inbred Strains; Nociceptors; Nose; Odorants; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Turpentine; Urea | 2000 |
Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist.
Topics: Analgesics; Animals; Binding, Competitive; Capsaicin; Cells, Cultured; Diterpenes; Drug Interactions; Humans; Iodine Radioisotopes; Mice; Oocytes; Pain; Pain Measurement; Radioligand Assay; Receptors, Drug; Transfection; TRPV Cation Channels; Xenopus laevis | 2001 |
Sensory assessment of regional analgesia in humans: a review of methods and applications.
Topics: Anesthesia, Conduction; Capsaicin; Electric Stimulation; Evoked Potentials, Somatosensory; Humans; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tourniquets; Transcutaneous Electric Nerve Stimulation | 2000 |
Capsaicin-induced pain and tourniquet constriction.
Topics: Capsaicin; Hand; Humans; Injections, Intravenous; Pain; Tourniquets | 2000 |
Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography.
Topics: Acute Disease; Adult; Capsaicin; Evoked Potentials, Somatosensory; Hand; Humans; Magnetoencephalography; Male; Nerve Fibers; Neuronal Plasticity; Nociceptors; Pain; Somatosensory Cortex | 2001 |
The role of spinal cholecystokinin B receptors in thermal allodynia and hyperalgesia in diabetic mice.
Topics: Animals; Capsaicin; Cholecystokinin; Diabetes Mellitus, Experimental; Enzyme Activators; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Male; Meglumine; Mice; Mice, Inbred ICR; Nerve Fibers; Nociceptors; Pain; Protein Kinase C; Reaction Time; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Spinal Cord | 2001 |
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Freund's Adjuvant; Hyperalgesia; Ketorolac; Macaca mulatta; Male; Morphine; Pain; Pain Measurement; Piperazines; Receptors, Opioid, delta | 2001 |
Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor.
Topics: Animals; Capsaicin; Gene Targeting; Inflammation; Male; Mice; Mice, Inbred BALB C; Mutagenesis; Pain; Pain Threshold; Plasma; Receptors, Neuropeptide Y; Substance P | 2001 |
Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity.
Topics: Afferent Pathways; Animals; Axonal Transport; Capsaicin; Colchicine; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Nerve Endings; Oligodeoxyribonucleotides, Antisense; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Nerve; Transcription, Genetic | 2001 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Involvement of spinal NK2 and NMDA receptors in aversive behavior induced by intra-arterial injection of capsaicin.
Topics: Animals; Avoidance Learning; Biphenyl Compounds; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Femoral Artery; Guinea Pigs; Hindlimb; Injections, Intra-Arterial; Male; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Spinal Cord; Vocalization, Animal | 2001 |
Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Exocytosis; In Vitro Techniques; Male; Pain; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Trigeminal Ganglion; Trigeminal Nerve | 2001 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome | 2001 |
The effect of Rapid Induction Analgesia on subjective pain ratings and pain tolerance.
Topics: Adolescent; Adult; Analgesia; Capsaicin; Female; Humans; Hypnosis; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Pain Threshold; Time Factors | 2001 |
Topographic effects of tonic cutaneous nociceptive stimulation on human electroencephalograph.
Topics: Adult; Alpha Rhythm; Brain; Brain Mapping; Capsaicin; Electroencephalography; Humans; Injections, Intradermal; Male; Nociceptors; Pain; Reference Values; Skin | 2001 |
Histamine H1 receptor mRNA is expressed in capsaicin-insensitive sensory neurons with neuropeptide Y-immunoreactivity in guinea pigs.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Ganglia, Spinal; Guinea Pigs; Histamine; Immunohistochemistry; Male; Nerve Fibers; Neurons, Afferent; Neuropeptide Y; Nociceptors; Pain; Posterior Horn Cells; Receptors, Histamine H1; RNA, Messenger | 2001 |
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia.
Topics: Adenosine Triphosphate; Capsaicin; Cells, Cultured; Drug Synergism; Humans; Hyperalgesia; Pain; Protein Kinase C; Receptors, Drug; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate | 2001 |
A new model of visceral pain and referred hyperalgesia in the mouse.
Topics: Abdomen; Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Female; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Mustard Plant; Pain; Plant Extracts; Plant Oils; Touch | 2001 |
Changes in cytosolic calcium in response to noxious heat and their relationship to vanilloid receptors in rat dorsal root ganglion neurons.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Capsaicin; Cells, Cultured; Cytosol; Female; Fluorescent Dyes; Fura-2; Ganglia, Spinal; Hot Temperature; Male; Myocardium; Neurons, Afferent; Nociceptors; Pain; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Drug; Signal Transduction; Thermosensing | 2001 |
Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE).
Topics: Afferent Pathways; Animals; Capsaicin; Cystitis, Interstitial; Enkephalins; Female; Genetic Therapy; Genetic Vectors; Herpesviridae; Pain; Pain Management; Protein Precursors; Rats; Urinary Bladder; Urinary Bladder Diseases | 2001 |
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Cholera Toxin; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GTP-Binding Proteins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Neurons; Nociceptors; Pain; Pain Measurement; Pain Threshold; Pertussis Toxin; Spinal Cord; Substance P; Synaptic Transmission; Virulence Factors, Bordetella | 2001 |
Hot chili, a cook and EMLA.
Topics: Anesthetics, Local; Capsaicin; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Prilocaine | 2001 |
Stimulation of chemosensitive afferents from multifidus muscle does not sensitize multifidus muscle spindles to vertebral loads in the lumbar spine of the cat.
Topics: Action Potentials; Afferent Pathways; Animals; Bradykinin; Capsaicin; Cats; Chemoreceptor Cells; Compressive Strength; Lumbar Vertebrae; Lumbosacral Region; Muscle Spindles; Muscle, Skeletal; Pain; Spasm; Weight-Bearing | 2001 |
The effects of capsaicin cream on prostaglandin-induced allodynia.
Topics: Animals; Capsaicin; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Male; Mice; Nerve Fibers; Ointments; Pain; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2001 |
Influence of capsaicin cream in rats with peripheral neuropathy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Benzamides; Capsaicin; Carrageenan; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Isoindoles; Male; Neuroprotective Agents; Pain; Peripheral Nervous System Diseases; Piperidines; Postoperative Period; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance Withdrawal Syndrome; Time Factors | 2001 |
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia.
Topics: Adult; Capsaicin; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Myelinated; Nociceptors; Pain; Radial Nerve; Somatosensory Disorders | 2001 |
Neuronal nitric oxide synthase (nNOS) mRNA is down-regulated, and constitutive NOS enzymatic activity decreased, in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite.
Topics: Animals; Arginine; Capsaicin; Ganglia, Spinal; Lumbar Vertebrae; Male; Nerve Degeneration; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Thoracic Vertebrae | 2001 |
NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blotting, Western; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Functional Laterality; gamma-Aminobutyric Acid; Inflammation; Injections, Intradermal; Interneurons; Male; Membrane Potentials; Neural Conduction; Neural Inhibition; Nociceptors; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2001 |
Why are chillies pungent?
Topics: Animals; Capsaicin; Capsicum; Humans; Nociceptors; Pain; Receptors, Drug; Seeds; Taste | 2001 |
Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.
Topics: Anesthetics, Intravenous; Binding Sites; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Nervous System; Pain; Patch-Clamp Techniques; Propofol; Receptors, Drug | 2001 |
Capsaicin as a source for painful stimulation in functional MRI.
Topics: Animals; Brain; Capsaicin; Magnetic Resonance Imaging; Nociceptors; Pain; Rats; Rats, Sprague-Dawley | 2001 |
Transient inhibition of the human motor cortex by capsaicin-induced pain. A study with transcranial magnetic stimulation.
Topics: Adult; Afferent Pathways; Capsaicin; Efferent Pathways; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Female; Functional Laterality; Humans; Male; Motor Cortex; Muscle Contraction; Neural Inhibition; Neural Pathways; Nociceptors; Pain; Pain Measurement; Skin; Somatosensory Cortex; Transcranial Magnetic Stimulation | 2001 |
The proteinase-activated receptor 2 is involved in nociception.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Drug Administration Routes; Ganglia, Spinal; Male; Neurons, Afferent; Pain; Pain Measurement; Pancreas; Pancreatic Ducts; Posterior Horn Cells; Potassium Chloride; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, Thrombin | 2001 |
Noxious heat-induced CGRP release from rat sciatic nerve axons in vitro.
Topics: Animals; Axons; Calcitonin Gene-Related Peptide; Capsaicin; Coloring Agents; Dose-Response Relationship, Drug; Ganglia, Spinal; Hot Temperature; Male; Nociceptors; Pain; Potassium; Rats; Rats, Wistar; Receptors, Drug; Ruthenium Red; Sciatic Nerve | 2001 |
Different EEG topographic effects of painful and non-painful intramuscular stimulation in man.
Topics: Adult; Brain Mapping; Capsaicin; Cerebral Cortex; Electroencephalography; Evoked Potentials, Somatosensory; Humans; Male; Muscle, Skeletal; Nociceptors; Pain; Pain Measurement | 2001 |
Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner.
Topics: Action Potentials; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, N-Type; Capsaicin; Electrophysiology; Evoked Potentials, Somatosensory; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Opioid Peptides; Pain; Pain Insensitivity, Congenital; Pain Measurement; Receptors, GABA-A; Receptors, Tachykinin; Spinal Nerve Roots; Time Factors | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzoquinones; Bradykinin; Capsaicin; Disease Models, Animal; Female; Indomethacin; Lactic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Propionates; Prostaglandins; Receptors, Drug; Receptors, Prostaglandin | 2001 |
Involvement of capsaicin-sensitive fibers in spinal NMDA-induced glutamate release.
Topics: Animals; Animals, Newborn; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lumbar Vertebrae; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
Involvement of spinal N-methyl-D-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; Nerve Fibers; Nociceptors; Pain; Posterior Horn Cells; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance P; Synapses; Synaptic Transmission | 2001 |
A human oral capsaicin pain model to assess topical anesthetic-analgesic drugs.
Topics: Administration, Topical; Adult; Anesthetics, Local; Capsaicin; Female; Genetic Variation; Humans; Lidocaine; Male; Models, Neurological; Nociceptors; Pain; Pain Measurement; Tongue | 2001 |
Cooling inhibits capsaicin-induced currents in cultured rat dorsal root ganglion neurones.
Topics: Action Potentials; Animals; Capsaicin; Cells, Cultured; Cold Temperature; Cryotherapy; Ganglia, Spinal; Hypothermia, Induced; Inflammation; Neurons, Afferent; Nociceptors; Pain; Pain Management; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Drug; TRPV Cation Channels | 2002 |
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; Capsaicin; Carrageenan; Central Nervous System; CHO Cells; Cricetinae; Disease Models, Animal; Edema; Extravasation of Diagnostic and Therapeutic Materials; Gene Expression; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Mice; Neurogenic Inflammation; Pain; Pain Measurement; Piperidines; Proto-Oncogene Proteins c-fos; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Species Specificity; Spinal Cord; Transfection; Tritium | 2002 |
Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Ginsenosides; Ion Channels; Oocytes; Pain; Receptors, Drug; Saponins; Xenopus laevis | 2001 |
Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons--evidence for a new mechanism of action.
Topics: Animals; Aspirin; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Hot Temperature; Ion Channels; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction; Thermosensing | 2002 |
Attenuation of thermal nociception and hyperalgesia by VR1 blockers.
Topics: Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Hot Temperature; Hyperalgesia; Inflammation; Knee; Male; Mice; Mice, Inbred ICR; Mustard Plant; Neurons; Pain; Pain Threshold; Peptoids; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Receptors, Drug; Recombinant Proteins; Stress, Mechanical; Time Factors; Xenopus | 2002 |
Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.
Topics: Animals; Benzimidazoles; Capsaicin; Female; Heating; Macaca mulatta; Male; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Piperidines; Receptors, Opioid; Tail | 2002 |
Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Capsaicin; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Nerve Fibers; Nerve Fibers, Myelinated; Neural Conduction; Nociceptors; Pain; Polyunsaturated Alkamides; Rats; Substantia Gelatinosa; Synaptic Transmission | 2002 |
Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Disinfectants; Electrophysiology; Formaldehyde; Histamine; Injections, Intradermal; Irritants; Male; Pain; Posterior Horn Cells; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin | 2002 |
Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents.
Topics: Animals; Antibodies, Blocking; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Gangliosides; Hyperalgesia; Infusions, Intravenous; Injections, Spinal; Male; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2002 |
The relationship between propagated contractions and pseudoaffective changes in blood pressure in response to intestinal distension.
Topics: Adrenergic alpha-Antagonists; Affect; Anesthetics, Local; Animals; Blood Pressure; Capsaicin; Heart Rate; Intestines; Lidocaine; Mesentery; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Pain; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley; Reflex | 2001 |
mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Narcotic Antagonists; Neurons; Nociceptors; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 2002 |
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
Topics: Animals; Arachidonic Acids; Benzoxazines; Camphanes; Cannabinoid Receptor Modulators; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Mice; Mice, Inbred Strains; Mice, Knockout; Morpholines; Multiple Sclerosis; Muscle Spasticity; Naphthalenes; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; Pain; Periaqueductal Gray; Phosphoserine; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Glutamate; Riluzole; Rimonabant; Time Factors | 2002 |
The roles of pathways in the spinal cord lateral and dorsal funiculi in signaling nociceptive somatic and visceral stimuli in rats.
Topics: Animals; Capsaicin; Catheterization; Colon; Cordotomy; Electromyography; Exploratory Behavior; Injections, Intradermal; Male; Mustard Plant; Nociceptors; Pain; Plant Extracts; Plant Oils; Posterior Horn Cells; Rats; Rats, Wistar; Rhizotomy; Spinothalamic Tracts; Visceral Afferents | 2002 |
Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Behavior, Animal; Capsaicin; Cells, Cultured; Down-Regulation; Ganglia, Spinal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; RNA, Messenger; Signal Transduction | 2002 |
Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity.
Topics: Animals; Bee Venoms; Capsaicin; Carrageenan; Dynorphins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Multivariate Analysis; Neurogenic Inflammation; Nociceptors; Pain; Pain Measurement; Species Specificity; Tail | 2002 |
Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism.
Topics: Afferent Pathways; Animals; Biological Assay; Calcitonin Gene-Related Peptide; Calcium; Cannabinoids; Cannabinol; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Female; Hepatic Artery; In Vitro Techniques; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pain; Psychotropic Drugs; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Vasodilation | 2002 |
Spinal administration of capsazepine inhibits noxious evoked responses of dorsal horn neurons in non-inflamed and carrageenan inflamed rats.
Topics: Action Potentials; Afferent Pathways; Animals; Capsaicin; Carrageenan; Dose-Response Relationship, Drug; Inflammation; Injections, Spinal; Male; Nerve Fibers; Nerve Fibers, Myelinated; Neural Inhibition; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Drug | 2002 |
Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway.
Topics: Adenylyl Cyclase Inhibitors; Animals; Behavior, Animal; Capsaicin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hot Temperature; Inflammation; Injections; Joints; Kinetics; Male; Muscles; Organ Specificity; Pain; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Skin; Stress, Mechanical | 2002 |
Modulation of trigeminal laser evoked potentials and laser silent periods by homotopical experimental pain.
Topics: Administration, Topical; Adult; Capsaicin; Cerebral Cortex; Cheek; Dose-Response Relationship, Radiation; Electromyography; Evoked Potentials, Visual; Female; Humans; Injections, Intramuscular; Lasers; Male; Masseter Muscle; Pain; Reaction Time; Skin; Sodium Chloride; Temporal Muscle; Trigeminal Nerve | 2002 |
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Hot Temperature; Injections, Spinal; Movement; Nociceptors; Pain; Rats; Spinal Cord; Substance P; Synaptic Transmission | 1979 |
Nociceptive threshold after neonatal capsaicin treatment.
Topics: Animals; Animals, Newborn; Capsaicin; Fatty Acids, Unsaturated; Pain; Rats; Reaction Time; Sensory Thresholds | 1979 |
Salivary cooling, escape reaction and heat pain in capsaicin-desensitized rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Capsaicin; Escape Reaction; Fatty Acids, Unsaturated; Grooming; Hot Temperature; Male; Pain; Rats; Salivary Glands | 1979 |
A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain.
Topics: Action Potentials; Animals; Bradykinin; Capsaicin; Cats; Fatty Acids, Unsaturated; Hot Temperature; Humans; Nerve Endings; Neural Conduction; Nociceptors; Pain; Rats; Skin; Taste Buds; Thermoreceptors; Time Factors; Tongue | 1977 |
Sensory effects of capsaicin congeners. Part II: Importance of chemical structure and pungency in desensitizing activity of capsaicin-type compounds.
Topics: Animals; Capsaicin; Condiments; Fatty Acids, Unsaturated; Homovanillic Acid; Pain; Rats; Sensory Receptor Cells; Structure-Activity Relationship; Vanillic Acid | 1976 |
Functional linkage between nociception and fluoride-resistant acid phosphatase activity in the Rolando substance.
Topics: Acid Phosphatase; Animals; Capsaicin; Depression, Chemical; Fatty Acids, Unsaturated; Fluorides; Pain; Rats; Sensory Receptor Cells; Spinal Cord | 1975 |
Sensory effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents.
Topics: Animals; Butanones; Capsaicin; Condiments; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Homovanillic Acid; Pain; Piperidines; Rats; Sensory Receptor Cells; Structure-Activity Relationship | 1975 |
Neonatal capsaicin treatment prevents the development of the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Hot Temperature; Male; Nervous System Diseases; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1992 |
Intrathecal oxymetazoline does not produce neurotoxicity in the spinal cord of the rat.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Gait; Immunohistochemistry; Injections, Spinal; Male; Motor Activity; Neurotoxins; Oxymetazoline; Pain; Posture; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1992 |
Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat.
Topics: Animals; Biphenyl Compounds; Capsaicin; Hot Temperature; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin A; Neuropeptides; Nociceptors; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 1992 |
Is guanylate cyclase activation through the release of nitric oxide or a related compound involved in bradykinin-induced perivascular primary afferent excitation?
Topics: Animals; Bradykinin; Capsaicin; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Female; Guanylate Cyclase; Male; Neurons, Afferent; Nitric Oxide; Nociceptors; Pain; Receptors, Bradykinin; Receptors, Neurotransmitter; Serotonin | 1992 |
Measuring subjective symptoms.
Topics: Capsaicin; Diabetic Neuropathies; Humans; Pain; Pain Measurement | 1992 |
Dynamic and static components of mechanical hyperalgesia in human hairy skin.
Topics: Adult; Capsaicin; Female; Hair; Hot Temperature; Humans; Irritants; Male; Middle Aged; Mustard Plant; Nerve Fibers, Myelinated; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Plant Extracts; Plant Oils; Pressure; Radial Nerve; Skin; Skin Temperature | 1992 |
Bradykinin modulation of a spinal nociceptive reflex in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Bradykinin; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Heart Rate; Methysergide; Nociceptors; Pain; Phentolamine; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Vagus Nerve | 1992 |
Capsaicin--a topical analgesic.
Topics: Administration, Cutaneous; Analgesics; Arthritis; Capsaicin; Clinical Trials as Topic; Diabetic Neuropathies; Herpes Zoster; Humans; Pain | 1992 |
[Capsaicin and neurogenic pain: a new use for an old substance].
Topics: Capsaicin; Humans; Nerve Endings; Neuralgia; Nociceptors; Pain; Pain, Intractable; Synaptic Transmission | 1991 |
Topical capsaicin therapy for neuropathic pain.
Topics: Administration, Topical; Capsaicin; Humans; Pain; Peripheral Nervous System Diseases | 1991 |
Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Capsaicin; Functional Laterality; Hot Temperature; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neuronal Plasticity; Neuropeptides; Pain; Quinoxalines; Rats; Reflex; Time Factors | 1991 |
Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.
Topics: Animals; Capsaicin; Cysteamine; Drug Interactions; Formaldehyde; Mice; Pain; Pain Measurement; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1990 |
[Relation of capsaicin-sensitive neurones to the effect of electro-acupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Capsaicin; Electroacupuncture; Male; Nerve Fibers; Neurons; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P | 1990 |
The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; alpha-Cyclodextrins; Analgesia; Animals; beta-Cyclodextrins; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Ventricles; Cyclodextrins; Dimethyl Sulfoxide; Electroencephalography; Enkephalin, Leucine-2-Alanine; gamma-Cyclodextrins; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Motor Activity; Naloxone; Narcotics; Pain; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Solubility; Substance P; Time Factors | 1991 |
Neonatal capsaicin treatment abolishes the nociceptive responses to intravenous 5-HT in the rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Hot Temperature; Injections, Intravenous; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Reaction Time; Serotonin; Skin Physiological Phenomena; Spinal Cord; Substance P | 1991 |
Activation of primary afferents in the rabbit ear by noxious heat.
Topics: Afferent Pathways; Animals; Bradykinin; Capsaicin; Ear; Hot Temperature; Pain; Potassium; Rabbits; Substance P | 1991 |
Involvement of substance P in hyperalgesia induced by intrathecal galanin.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Capsaicin; Carrageenan; Galanin; Guinea Pigs; Ileum; In Vitro Techniques; Inflammation; Injections, Spinal; Male; Muscle, Smooth; Neurokinin A; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Substance P | 1991 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; Indomethacin; Inflammation; Mice; Morphine; Neurons; Pain; Spinal Cord | 1991 |
Impaired escape reaction from noxious and nonnoxious heat in rats treated with the selective noradrenergic neurotoxin DSP-4.
Topics: Animals; Benzylamines; Body Temperature Regulation; Capsaicin; Escape Reaction; Hot Temperature; Locus Coeruleus; Male; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Sympathomimetics | 1991 |
Further behavioral evidence that colorectal distension is a 'noxious' visceral stimulus in rats.
Topics: Animals; Avoidance Learning; Capsaicin; Colon; Inflammation; Male; Morphine; Motor Activity; Muscle Contraction; Muscle, Smooth; Pain; Rats; Rats, Inbred Strains; Rectum; Turpentine | 1991 |
Biosynthesis and release of tachykinins from rat sensory neurons in culture.
Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Chromatography, High Pressure Liquid; Ganglia, Spinal; Inflammation; Neurons, Afferent; Neuropeptides; Nifedipine; Pain; Potassium; Radioimmunoassay; Rats; RNA, Messenger; Tachykinins; Trigeminal Ganglion | 1991 |
Kallidin applied to the human nasal mucosa produces algesic response not blocked by capsaicin desensitization.
Topics: Adult; Capsaicin; Female; Humans; Ipratropium; Kallidin; Kinins; Male; Nasal Mucosa; Pain; Tachykinins | 1991 |
Spinal evoked potential P2 wave elicited by C fiber input and depressed by analgesic factors.
Topics: Analgesia; Animals; Capsaicin; Electroacupuncture; Evoked Potentials; Foot; Hot Temperature; Injections, Spinal; Male; Morphine; Naloxone; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1991 |
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms.
Topics: Adult; Aged; Anesthesia, Local; Capsaicin; Central Nervous System; Female; Humans; Hyperalgesia; Lymph; Male; Middle Aged; Nerve Fibers; Nervous System Physiological Phenomena; Neurons; Pain; Peripheral Nerves; Physical Stimulation; Psychophysics; Regional Blood Flow; Skin | 1991 |
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Intradermal; Macaca fascicularis; Nerve Fibers; Nervous System Physiological Phenomena; Nociceptors; Pain; Physical Stimulation; Skin | 1991 |
Cooling the burn from hot peppers.
Topics: Animals; Capsaicin; Capsicum; Humans; Milk; Mouth Mucosa; Pain; Plants, Medicinal | 1991 |
Resiniferatoxin. An ultrapotent neurotoxin of capsaicin-sensitive primary afferent neurons.
Topics: Afferent Pathways; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Heart Rate; Hot Temperature; Neurons; Neurotoxins; Pain; Rats | 1991 |
Kynurenic acid blocks chemogenic nociception.
Topics: Animals; Behavior, Animal; Capsaicin; Cisterna Magna; Dizocilpine Maleate; Injections; Kynurenic Acid; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Topical capsaicin in the treatment of painful diabetic neuropathy.
Topics: Administration, Topical; Capsaicin; Chronic Disease; Diabetic Neuropathies; Humans; Pain | 1991 |
Preproenkephalin upregulation in nucleus caudalis: high and low intensity afferent stimulation differentially modulate early and late responses.
Topics: Afferent Pathways; Animals; Animals, Newborn; Capsaicin; Electric Stimulation; Enkephalins; Gene Expression Regulation; Male; Pain; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Trigeminal Nerve | 1990 |
[The effect of extradural injection of capsaicin on pain threshold and electroacupuncture analgesia of rat].
Topics: Acupuncture Analgesia; Animals; Capsaicin; Electroacupuncture; Female; Immunohistochemistry; Injections, Spinal; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord | 1990 |
The effect of neonatal capsaicin on acupuncture analgesia--to evaluate the role of C fibers in acupuncture analgesia.
Topics: Action Potentials; Acupuncture Analgesia; Afferent Pathways; Animals; Capsaicin; Electroacupuncture; Nerve Fibers; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds | 1990 |
The measurement of capsaicin-sensitive sensory nerve fiber function in elderly patients with pain.
Topics: Aged; Back Pain; Capsaicin; Female; Herpesviridae Infections; Humans; Lasers; Male; Nerve Fibers; Neuralgia; Pain; Pain Measurement; Psychometrics; Psychophysiologic Disorders; Regional Blood Flow; Reproducibility of Results; Self Concept; Sensation | 1990 |
A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats.
Topics: Afferent Pathways; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Hot Temperature; Hyperalgesia; Hyperesthesia; Lasers; Male; Nerve Fibers; Pain; Rats; Rats, Inbred Strains; Reference Values; Sensory Thresholds; Skin; Touch | 1990 |
Neuroparalytic keratitis and capsaicin.
Topics: Animals; Aqueous Humor; Capillary Permeability; Capsaicin; Denervation; Evans Blue; Keratitis; Male; Neuropeptides; Ophthalmic Nerve; Pain; Rats; Rats, Inbred Strains | 1990 |
Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions.
Topics: Animals; Capsaicin; Dermatitis, Contact; Female; Hypersensitivity, Delayed; Lymph Nodes; Mast Cells; Mice; Mice, Inbred BALB C; Neurons, Afferent; Neuropeptides; Pain | 1990 |
Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin.
Topics: Acetaminophen; Animals; Aspirin; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Morphine; Pain; Substance P | 1985 |
Capsaicin in adult frogs: effects on nociceptive responses to cutaneous stimuli and on nervous tissue concentrations of immunoreactive substance P, somatostatin and cholecystokinin.
Topics: Animals; Brain Chemistry; Capsaicin; Cholecystokinin; Chromatography, Gel; Electric Stimulation; Hot Temperature; Nerve Tissue; Pain; Radioimmunoassay; Rana esculenta; Sensory Thresholds; Somatostatin; Spinal Cord; Stimulation, Chemical; Substance P; Time Factors | 1985 |
Analgesic activities of spinal cord substance P antagonists implicate substance P as a neurotransmitter of pain sensation.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Injections, Spinal; Iodine Radioisotopes; Mice; Pain; Piperazines; Somatostatin; Substance P | 1986 |
Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Neuropeptides; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1987 |
Effect of capsaicin upon afferent and efferent mechanisms of nociception and temperature regulation in birds.
Topics: Afferent Pathways; Animals; Birds; Body Temperature Regulation; Capsaicin; Chickens; Columbidae; Ducks; Efferent Pathways; Nociceptors; Pain; Rats; Sciatic Nerve; Spinal Cord; Substance P | 1987 |
Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Indomethacin; Male; Mice; Morphine; Nerve Fibers; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Sciatic Nerve; Substance P; Time Factors | 1989 |
[Thermal analgesia following intrathecal capsaicin administration in rats--detailed measurements of thermal analgesia over the lower body by a thermal probe].
Topics: Analgesics; Animals; Capsaicin; Female; Hot Temperature; Injections, Spinal; Pain; Pain Measurement; Rats; Rats, Inbred Strains | 1989 |
Inverse relationship between intensity of vaginal self-stimulation-produced analgesia and level of chronic intake of a dietary source of capsaicin.
Topics: Adult; Analgesia; Capsaicin; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; Pain; Self Stimulation; Sensory Thresholds; Touch; Vagina | 1989 |
On the nature of the afferent fibers of oculomotor nerve.
Topics: Animals; Bradykinin; Capsaicin; Histamine; Hot Temperature; Nociceptors; Oculomotor Nerve; Pain; Sheep | 1989 |
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper.
Topics: Animals; Capsaicin; Diterpenes; Female; Hypothermia; Inflammation; Pain; Rats; Rats, Inbred Strains | 1989 |
Capsaicin desensitization of peripheral nociceptive fibres does not impair sensitivity to other noxious stimuli.
Topics: Animals; Bradykinin; Capsaicin; Drug Tolerance; Hot Temperature; In Vitro Techniques; Nociceptors; Pain; Peripheral Nerves; Rats; Sensory Thresholds; Spinal Cord | 1989 |
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin.
Topics: Capsaicin; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Hyperesthesia; Pain; Pain Measurement; Physical Stimulation; Time Factors | 1989 |
The post-mastectomy pain syndrome and the effect of topical capsaicin.
Topics: Administration, Topical; Adult; Aged; Breast Neoplasms; Capsaicin; Female; Follow-Up Studies; Humans; Intercostal Nerves; Mastectomy; Middle Aged; Pain; Thoracic Nerves; Time Factors | 1989 |
Heat and mechanical hyperalgesia induced by capsaicin. Cross modality threshold modulation in human C nociceptors.
Topics: Biomechanical Phenomena; Body Temperature; Capsaicin; Constriction; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Hyperesthesia; Nerve Block; Nociceptors; Pain; Physical Stimulation; Sensory Thresholds; Skin | 1989 |
Measurement of flare responses in patients with pain.
Topics: Adult; Aged; Capsaicin; Chronic Disease; Female; Humans; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System Diseases | 1987 |
Analgesic effect of morphine: a role for beta-endorphin.
Topics: Animals; beta-Endorphin; Brain; Capsaicin; Endorphins; Injections, Intraventricular; Male; Morphine; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Sensory Thresholds | 1987 |
Effects of capsaicin on central monoaminergic mechanisms in the rat.
Topics: Animals; Animals, Newborn; Body Temperature; Capsaicin; Catecholamines; Central Nervous System; Male; Pain; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission | 1986 |
Spinal cord alpha 2-adrenoceptors may be located postsynaptically with respect to primary sensory neurons: destruction of primary C-afferents with neonatal capsaicin does not affect the number of [3H]clonidine binding sites in mice.
Topics: Animals; Animals, Newborn; Capsaicin; Clonidine; Mice; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Receptors, Adrenergic, alpha; Spinal Cord | 1987 |
Chemical irritant algesia assessed using the human blister base.
Topics: Blister; Bradykinin; Capsaicin; Dibenzoxazepines; Drug Interactions; Humans; Hydroxybenzoates; Nitriles; o-Chlorobenzylidenemalonitrile; Pain; Skin; Vanillic Acid | 1986 |
[Thermal analgesia following intrathecal capsaicin administration].
Topics: Animals; Capsaicin; Female; Hot Temperature; Injections, Spinal; Pain; Rats; Rats, Inbred Strains | 1988 |
Effects of capsaicin on articular afferents of the cat's knee joint.
Topics: Animals; Arthritis; Bradykinin; Capsaicin; Cats; Hindlimb; Joints; Neural Conduction; Neurons, Afferent; Pain | 1988 |
Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man.
Topics: Administration, Intranasal; Adult; Capsaicin; Female; Humans; Male; Nasal Mucosa; Pain; Sneezing | 1988 |
The contribution of capsaicin-sensitive sensory nerves to xylene-induced visceral pain in conscious, freely moving rats.
Topics: Aging; Animals; Animals, Newborn; Capsaicin; Female; Ganglia; Hot Temperature; Immersion; Neurons, Afferent; Neuropeptides; Pain; Rats; Rats, Inbred Strains; Reaction Time; Urinary Bladder; Xylenes | 1988 |
Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.
Topics: Animals; Burns; Capsaicin; Central Nervous System; Guanethidine; Hyperalgesia; Hyperesthesia; Male; Nerve Block; Nerve Fibers; Pain; Peripheral Nerves; Procaine; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Skin | 1987 |
[Effects of capsaicin on spontaneous unit discharges in amygdala single neurons of cats].
Topics: Action Potentials; Amygdala; Animals; Bradykinin; Brain Mapping; Capsaicin; Cats; Evoked Potentials; Female; Male; Morphine; Pain; Sensation | 1987 |
Epidural capsaicin produces prolonged segmental analgesia in the rat.
Topics: Analgesics; Animals; Capsaicin; Female; Injections, Epidural; Male; Pain; Rats; Sensory Thresholds | 1987 |
Regionally selective elimination of cutaneous thermal nociception in rats by neonatal capsaicin.
Topics: Animals; Animals, Newborn; Capsaicin; Female; Hot Temperature; Nerve Fibers; Pain; Peripheral Nerves; Rats; Rats, Inbred Strains; Sensory Thresholds; Skin | 1987 |
Hyperalgesia to heat after intradermal injection of capsaicin.
Topics: Analgesia; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Injections, Intradermal; Pain; Sensory Thresholds; Time Factors | 1987 |
Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bronchi; Capsaicin; Ear, External; Enkephalin, Methionine; Female; Fentanyl; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Narcotics; Neurons; Pain; Rabbits | 1987 |
Nociception in pigeons is not impaired by capsaicin.
Topics: Animals; Blood Pressure; Bradykinin; Capsaicin; Columbidae; Dose-Response Relationship, Drug; Female; Guinea Pigs; Injections, Intra-Arterial; Male; Mustard Plant; Pain; Plant Extracts; Plant Oils; Respiration; Sensory Thresholds; Species Specificity; Veratridine | 1986 |
Loss of spinothalamic tract neurons following neonatal treatment of rats with the neurotoxin capsaicin.
Topics: Age Factors; Animals; Animals, Newborn; Capsaicin; Female; Pain; Rats; Spinothalamic Tracts | 1986 |
Evaluation of the analgesic effects of capsaicin using a new rat model for tonic pain.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
Effects of capsaicin applied to a peripheral nerve on the responses of primate spinothalamic tract cells.
Topics: Animals; Capsaicin; Evoked Potentials, Somatosensory; Female; Macaca fascicularis; Male; Nerve Fibers; Nerve Fibers, Myelinated; Neural Conduction; Nociceptors; Pain; Peripheral Nerves; Spinothalamic Tracts | 1985 |
[Effects of serial administration of vanillyl n-nonoylamide on vocalization responses by arterial algogenics in guinea pigs].
Topics: Acetylcholine; Analgesics; Animals; Bradykinin; Capsaicin; Chemoreceptor Cells; Guinea Pigs; Hydroxybenzoates; Male; Nociceptors; Pain; Vanillic Acid; Vocalization, Animal | 1985 |
Neurogenic flare responses following topical application of capsaicin in humans.
Topics: Administration, Topical; Afferent Pathways; Aging; Capsaicin; Humans; Inflammation; Nervous System Physiological Phenomena; Nociceptors; Osmolar Concentration; Pain; Statistics as Topic | 1985 |