Page last updated: 2024-08-24

capecitabine and Encephalopathy, Toxic

capecitabine has been researched along with Encephalopathy, Toxic in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (15.63)29.6817
2010's21 (65.63)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Li, Y; Tang, X; Wu, X; Zhong, W1
Gao, JL; Ong, CS; Tan, YJ1
Allahyari, A; Barri, A; Bondad, N; Boostani, R; Elyasi, S1
Amadori, E; Barone, D; Bartolini, G; Frassineti, GL; Monti, M; Ruscelli, S1
Chen, H; Lu, Y; Xu, C; Xu, L; Yao, Q; Yao, W; Zhang, L; Zhang, R; Zhang, X1
Gui, Q; Li, D; Xu, C; Zhuge, Y1
Araújo, F; Baptista, MJ; Casa-Nova, M; Godinho, J; Mesquita, T; Passos Coelho, JL; Vale, J1
Aapro, M; Bondarenko, I; Campone, M; Krishnamurthy, S; Lebedeva, L; Martin, M; Roman, L; Sakaeva, D; Vedovato, JC1
Alberti, P; Angelopoulou, A; Antonacopoulou, A; Argyriou, AA; Briani, C; Bruna, J; Campagnolo, M; Cavaletti, G; Cazzaniga, M; Cortinovis, D; Genazzani, AA; Kalofonos, HP; Lonardi, S; Psaromyalou, A; Santos, C; Terrazzino, S; Velasco, R1
Fassbender, K; Keller, I; Lyros, E; Papanagiotou, P; Walter, S1
Alberti, P; Argyriou, AA; Bergamo, F; Briani, C; Bruna, J; Cacciavillani, M; Campagnolo, M; Cavaletti, G; Cazzaniga, M; Cortinovis, D; Frigeni, B; Izquierdo, C; Kalofonos, HP; Velasco, R1
Dimopoulos, MA; Karandreas, N; Kokotis, P; Kostouros, E; Schmelz, M1
Inukai, M; Nagasaka, T; Okajima, M; Tanioka, H; Toyota, K; Tsuji, A; Tsuruta, A; Yamakawa, T; Yamano, T; Yamashita, K; Yamatsuji, T; Yoshimitsu, M1
Antonini, NF; Gelderblom, H; Guchelaar, HJ; Kweekel, DM; Nortier, JW; Punt, CJ; Van der Straaten, T1
Kolluri, RB; Raouf, S; Tipples, K1
Cathomas, R; Köberle, D; Mayer, G; Mey, U; Räss, A; Ruhstaller, T; von Moos, R1
Ahmad, A; Gounaris, I1
Uña, E1
Isufi, I; Kaley, K; Saif, MW; Syrigos, K1
Bergin, P; Damianovich, D; Findlay, M; Hanning, F; Hill, A; McKeage, MJ; Thompson, P1
Bagli, L; Drudi, F; Fantini, M; Gianni, L; Nicoletti, S; Possenti, C; Ravaioli, A; Sintini, M; Tamburini, E; Tassinari, D1
Imholz, AL; Knijn, N; Koopman, M; Mol, L; Punt, CJ; Teerenstra, S; Tol, J; Valster, FA; Vincent, AD; Werter, MJ1
Chay, WY; Choo, SP; Gao, F; Koo, WH; Lo, YL; Ng, HC; Ong, SY; Tan, SH1
Friedlander, ML; Goldstein, D; Kiernan, MC; Krishnan, AV; Lin, CS; Park, SB1
Chen, XF; Guo, RH; Li, J; Røe, OD; Shu, YQ; Wang, R; Wu, T; Yin, YM; Zhu, LJ1
Alberti, P; Argyriou, AA; Briani, C; Bruna, J; Cacciavillani, M; Cavaletti, G; Cazzaniga, M; Cortinovis, D; Kalofonos, HP; Lonardi, S; Santos, C; Velasco, R1
Alberti, P; Argyriou, AA; Bergamo, F; Briani, C; Bruna, J; Cavaletti, G; Cazzaniga, M; Cortinovis, D; Kalofonos, HP; Lonardi, S; Lucchetta, M; Velasco, R1
Ji, T; Jiao, S; Yang, J; Zhu, Y1
Herrmann, R; Niemann, B; Pless, M; Rochlitz, C1
Fioravanti, S; Grem, JL; Harold, N; Leonard, GD; Quinn, MG; Schuler, B; Thomas, RR; Wright, MA1
Baddi, L; Beck, AC; Blumenthal, DT; Chua-Adajar, R; Futterer, S; Gradishar, W; Raizer, JJ; Semenov, I; Simuni, T; Tellez, C; Videnovic, A1

Reviews

3 review(s) available for capecitabine and Encephalopathy, Toxic

ArticleYear
Reversible Toxic Encephalopathy Involving the Cerebellum and Subcortical White Matter Attributed to Capecitabine.
    The American journal of the medical sciences, 2022, Volume: 363, Issue:4

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Cerebellum; Fluorouracil; Humans; Neurotoxicity Syndromes; White Matter

2022
Subacute reversible toxic encephalopathy related to treatment with capecitabine: a case report with literature review and discussion of pathophysiology.
    Neurotoxicology, 2014, Volume: 42

    Topics: Aged; Brain Edema; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Neurotoxicity Syndromes; Prodrugs; White Matter

2014
Toxic encephalopathy in elderly patients during treatment with capecitabine: literature review and a case report.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2011, Volume: 17, Issue:3

    Topics: Adenocarcinoma; Age Factors; Aged, 80 and over; Antimetabolites, Antineoplastic; Bone Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fatal Outcome; Female; Fluorouracil; Humans; Neurotoxicity Syndromes; Patient Selection; Risk Assessment; Risk Factors

2011

Trials

11 trial(s) available for capecitabine and Encephalopathy, Toxic

ArticleYear
Protective effect of N-acetylcysteine on oxaliplatin-induced neurotoxicity in patients with colorectal and gastric cancers: A randomized, double blind, placebo-controlled, clinical trial.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:7

    Topics: Acetylcysteine; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Oxaliplatin; Oxaloacetates; Stomach Neoplasms

2020
Prevention of oxaliplatin-related neurotoxicity by ω-3 PUFAs: A double-blind randomized study of patients receiving oxaliplatin combined with capecitabine for colon cancer.
    Medicine, 2020, Dec-11, Volume: 99, Issue:50

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colonic Neoplasms; Double-Blind Method; Drug Administration Schedule; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neurotoxicity Syndromes; Oxaliplatin; Peripheral Nervous System Diseases; Quality of Life; Surveys and Questionnaires

2020
Efficacy of Exercise Rehabilitation Program in Relieving Oxaliplatin Induced Peripheral Neurotoxicity.
    Asian Pacific journal of cancer prevention : APJCP, 2021, Mar-01, Volume: 22, Issue:3

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Digestive System Neoplasms; Dose-Response Relationship, Drug; Exercise Therapy; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Peripheral Nervous System Diseases

2021
Randomised phase III trial of vinflunine plus capecitabine versus capecitabine alone in patients with advanced breast cancer previously treated with an anthracycline and resistant to taxane.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 05-01, Volume: 29, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Capecitabine; Chemotherapy-Induced Febrile Neutropenia; Drug Resistance, Neoplasm; Female; Hand-Foot Syndrome; Humans; Middle Aged; Neoplasm Recurrence, Local; Neurotoxicity Syndromes; Peripheral Nervous System Diseases; Progression-Free Survival; Quality of Life; Survival Analysis; Taxoids; Vinblastine

2018
Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study.
    Drug design, development and therapy, 2016, Volume: 10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Colectomy; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Feasibility Studies; Female; Fluorouracil; Humans; Japan; Leucovorin; Male; Middle Aged; Motor Neurons; Neoplasm Staging; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; Prospective Studies; Risk Factors; Sensory Receptor Cells; Surveys and Questionnaires; Time Factors; Treatment Outcome

2016
Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectal cancer patients.
    European journal of cancer (Oxford, England : 1990), 2009, Volume: 45, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Codon; Colorectal Neoplasms; Deoxycytidine; Epidemiologic Methods; Female; Fluorouracil; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Polymorphism, Genetic; Treatment Outcome

2009
The effect of prophylactic calcium and magnesium infusions on the incidence of neurotoxicity and clinical outcome of oxaliplatin-based systemic treatment in advanced colorectal cancer patients.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Calcium; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Infusions, Intravenous; Magnesium; Male; Middle Aged; Neuroprotective Agents; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Retrospective Studies; Treatment Outcome

2011
Use of calcium and magnesium infusions in prevention of oxaliplatin induced sensory neuropathy.
    Asia-Pacific journal of clinical oncology, 2010, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Calcium Gluconate; Capecitabine; Cohort Studies; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Magnesium Sulfate; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Paresthesia; Retrospective Studies; Treatment Outcome; Young Adult

2010
Peripheral neurotoxicity of oxaliplatin in combination with 5-fluorouracil (FOLFOX) or capecitabine (XELOX): a prospective evaluation of 150 colorectal cancer patients.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Incidence; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Prospective Studies

2012
Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors.
    World journal of surgical oncology, 2013, Jan-25, Volume: 11

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cohort Studies; Deoxycytidine; Female; Fluorouracil; G(M1) Ganglioside; Gastrointestinal Neoplasms; Humans; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Peripheral Nervous System Diseases; Sialic Acids; Treatment Outcome; Young Adult

2013
Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer.
    BMC cancer, 2005, Sep-16, Volume: 5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Paresthesia; Surveys and Questionnaires; Time Factors; Treatment Outcome

2005

Other Studies

18 other study(ies) available for capecitabine and Encephalopathy, Toxic

ArticleYear
Capecitabine related neurotoxicity: Clinical and radiologic features.
    Journal of the neurological sciences, 2022, 11-15, Volume: 442

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Female; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Middle Aged; Neurotoxicity Syndromes; Retrospective Studies

2022
Posterior reversible encephalopathy syndrome: A rare neurotoxicity after capecitabine.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:7

    Topics: Capecitabine; Female; Fluorouracil; Humans; Magnetic Resonance Imaging; Middle Aged; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome; Risk Factors; Seizures

2020
Acute reversible toxic encephalopathy during capecitabine and oxaliplatin treatment.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:2

    Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cerebellar Ataxia; Colonic Neoplasms; Humans; Male; Neurotoxicity Syndromes; Oxaliplatin

2019
Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study.
    Cancer, 2013, Oct-01, Volume: 119, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fluorouracil; Genotype; Humans; Incidence; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; Polymorphism, Single Nucleotide; Prospective Studies; Treatment Outcome; Voltage-Gated Sodium Channels

2013
Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study.
    Journal of the peripheral nervous system : JPNS, 2014, Volume: 19, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease Progression; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Peripheral Nervous System Diseases; Prospective Studies; Recovery of Function

2014
Capecitabine: toxic encephalopathy.
    Prescrire international, 2015, Volume: 24, Issue:165

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Humans; Leukoencephalopathies; Neurotoxicity Syndromes

2015
Oxaliplatin-Induced Neuropathy: A Long-Term Clinical and Neurophysiologic Follow-Up Study.
    Clinical colorectal cancer, 2016, Volume: 15, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Electrophysiology; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases

2016
Encephalopathy secondary to capecitabine chemotherapy: a case report and discussion.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2009, Volume: 15, Issue:4

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Capecitabine; Cisplatin; Deoxycytidine; Epirubicin; Esophageal Neoplasms; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Neurotoxicity Syndromes

2009
Heated (37 degrees C) oxaliplatin infusion in combination with capecitabine for metastatic colorectal carcinoma: can it reduce neuropathy?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010, Volume: 18, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Feasibility Studies; Female; Fluorouracil; Hot Temperature; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Pilot Projects; Time Factors; Treatment Outcome

2010
Capecitabine-induced cerebellar toxicity in a patient with metastatic colorectal cancer.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2010, Volume: 16, Issue:4

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cerebellar Diseases; Colorectal Neoplasms; Deoxycytidine; Drug Monitoring; Female; Fluorouracil; Humans; Liver Neoplasms; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Prodrugs

2010
Atypical presentation of acute neurotoxicity secondary to oxaliplatin.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2010, Volume: 16, Issue:4

    Topics: Adenocarcinoma; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colonic Neoplasms; Deoxycytidine; Female; Fluorouracil; Humans; Leg; Middle Aged; Muscle Cramp; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Paresthesia; Treatment Outcome

2010
Role of pregabalin in treatment of oxaliplatin-induced sensory neuropathy.
    Anticancer research, 2010, Volume: 30, Issue:7

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Dose-Response Relationship, Drug; Epirubicin; Female; Fluorouracil; gamma-Aminobutyric Acid; Gastrointestinal Neoplasms; Gemcitabine; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Pregabalin

2010
Detecting acute neurotoxicity during platinum chemotherapy by neurophysiological assessment of motor nerve hyperexcitability.
    BMC cancer, 2010, Aug-23, Volume: 10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carboplatin; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Motor Neuron Disease; Neoplasm Staging; Neurophysiology; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Retrospective Studies; Survival Rate; Treatment Outcome

2010
Long-term neuropathy after oxaliplatin treatment: challenging the dictum of reversibility.
    The oncologist, 2011, Volume: 16, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Sensation Disorders; Surveys and Questionnaires; Treatment Outcome

2011
The effect of monosialotetrahexosylganglioside (GM1) in prevention of oxaliplatin induced neurotoxicity: a retrospective study.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2012, Volume: 66, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; G(M1) Ganglioside; Humans; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Retrospective Studies; Severity of Illness Index; Survival Rate; Treatment Outcome

2012
Incidence of atypical acute nerve hyperexcitability symptoms in oxaliplatin-treated patients with colorectal cancer.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:6

    Topics: Acute Disease; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deglutition Disorders; Deoxycytidine; Drug Administration Schedule; Dyspnea; Female; Fluorouracil; Humans; Incidence; Leucovorin; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Paresthesia; Prospective Studies; Spasm

2012
Toxic encephalopathy induced by capecitabine.
    Oncology, 2004, Volume: 66, Issue:4

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Epilepsy; Female; Fluorouracil; Humans; Lymphatic Metastasis; Magnetic Resonance Imaging; Middle Aged; Neurotoxicity Syndromes; Skin Neoplasms

2004
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.
    Neurology, 2005, Dec-13, Volume: 65, Issue:11

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain; Breast Neoplasms; Capecitabine; Carcinoma; Deoxycytidine; Female; Fluorouracil; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasm Metastasis; Neurotoxicity Syndromes; Pancreatic Neoplasms; Withholding Treatment

2005