cantharidin has been researched along with Pancreatic Neoplasms in 9 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Excerpt | Relevance | Reference |
---|---|---|
" Lovastatin showed no cytotoxicity in mesothelioma or pancreatic carcinoma cells at concentrations up to 10 μM and pH around 7." | 3.76 | Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin. ( Chiba, Y; Fukamachi, T; Kobayashi, H; Saito, H; Tagawa, M; Wang, X, 2010) |
"Cantharidin drove pancreatic cancer cells out of quiescent G0/G1 phase and arrested cell cycle in G2/M phase." | 1.48 | The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair. ( Gong, FR; Li, W; Liu, SL; Tao, M; Wu, J; Wu, MY; Xu, MD; Zhang, J; Zhang, Y; Zheng, BB, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 8 (88.89) | 24.3611 |
2020's | 1 (11.11) | 2.80 |
Authors | Studies |
---|---|
Liu, X | 1 |
Zhang, L | 1 |
Thu, PM | 1 |
Min, W | 1 |
Yang, P | 1 |
Li, J | 1 |
Li, P | 1 |
Xu, X | 1 |
Xu, MD | 1 |
Liu, SL | 1 |
Zheng, BB | 1 |
Wu, J | 1 |
Wu, MY | 4 |
Zhang, Y | 1 |
Gong, FR | 5 |
Tao, M | 6 |
Zhang, J | 2 |
Li, W | 7 |
Xie, X | 1 |
Xu, ZK | 2 |
Xie, L | 3 |
Chen, Z | 4 |
Shou, LM | 1 |
Xie, YF | 1 |
Shen, M | 2 |
Chen, LP | 1 |
Zhi, Q | 2 |
Chen, K | 2 |
Li, DM | 2 |
Wu, Y | 1 |
Wang, WJ | 1 |
Liu, ZY | 1 |
Zhu, Y | 3 |
Sun, Y | 2 |
Miao, Y | 3 |
Xu, Z | 2 |
Han, X | 3 |
Fukamachi, T | 1 |
Chiba, Y | 1 |
Wang, X | 1 |
Saito, H | 1 |
Tagawa, M | 1 |
Kobayashi, H | 1 |
Zong, Y | 2 |
Gong, F | 1 |
Lv, J | 1 |
Yin, H | 1 |
Duan, WM | 1 |
9 other studies available for cantharidin and Pancreatic Neoplasms
Article | Year |
---|---|
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cantharidin; Dose-Response Relationship, Drug; | 2021 |
The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair.
Topics: Cantharidin; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Dam | 2018 |
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin.
Topics: Anthracenes; beta Catenin; Cantharidin; Cell Movement; Cell Proliferation; Enzyme Inhibitors; Gene E | 2014 |
Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.
Topics: Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Repre | 2015 |
Cantharidin and norcantharidin impair stemness of pancreatic cancer cells by repressing the β-catenin pathway and strengthen the cytotoxicity of gemcitabine and erlotinib.
Topics: Apoptosis; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Cell Line, Tumor; Cel | 2015 |
Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis.
Topics: Apoptosis; Cantharidin; Cell Division; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; G2 P | 2010 |
Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin.
Topics: Cantharidin; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhib | 2010 |
PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cantharidin; Cell Line, Tumor; Cell Survival; E | 2011 |
Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway.
Topics: Cantharidin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Enzyme Inhibito | 2011 |