Page last updated: 2024-11-08

cantharidin and Pancreatic Neoplasms

cantharidin has been researched along with Pancreatic Neoplasms in 9 studies

Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
" Lovastatin showed no cytotoxicity in mesothelioma or pancreatic carcinoma cells at concentrations up to 10 μM and pH around 7."3.76Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin. ( Chiba, Y; Fukamachi, T; Kobayashi, H; Saito, H; Tagawa, M; Wang, X, 2010)
"Cantharidin drove pancreatic cancer cells out of quiescent G0/G1 phase and arrested cell cycle in G2/M phase."1.48The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair. ( Gong, FR; Li, W; Liu, SL; Tao, M; Wu, J; Wu, MY; Xu, MD; Zhang, J; Zhang, Y; Zheng, BB, 2018)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (88.89)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Liu, X1
Zhang, L1
Thu, PM1
Min, W1
Yang, P1
Li, J1
Li, P1
Xu, X1
Xu, MD1
Liu, SL1
Zheng, BB1
Wu, J1
Wu, MY4
Zhang, Y1
Gong, FR5
Tao, M6
Zhang, J2
Li, W7
Xie, X1
Xu, ZK2
Xie, L3
Chen, Z4
Shou, LM1
Xie, YF1
Shen, M2
Chen, LP1
Zhi, Q2
Chen, K2
Li, DM2
Wu, Y1
Wang, WJ1
Liu, ZY1
Zhu, Y3
Sun, Y2
Miao, Y3
Xu, Z2
Han, X3
Fukamachi, T1
Chiba, Y1
Wang, X1
Saito, H1
Tagawa, M1
Kobayashi, H1
Zong, Y2
Gong, F1
Lv, J1
Yin, H1
Duan, WM1

Other Studies

9 other studies available for cantharidin and Pancreatic Neoplasms

ArticleYear
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53.
    Science China. Life sciences, 2021, Volume: 64, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cantharidin; Dose-Response Relationship, Drug;

2021
The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2018, Volume: 18, Issue:7

    Topics: Cantharidin; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Dam

2018
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin.
    Oncology reports, 2014, Volume: 32, Issue:2

    Topics: Anthracenes; beta Catenin; Cantharidin; Cell Movement; Cell Proliferation; Enzyme Inhibitors; Gene E

2014
Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.
    Scientific reports, 2015, Jul-02, Volume: 5

    Topics: Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Repre

2015
Cantharidin and norcantharidin impair stemness of pancreatic cancer cells by repressing the β-catenin pathway and strengthen the cytotoxicity of gemcitabine and erlotinib.
    International journal of oncology, 2015, Volume: 47, Issue:5

    Topics: Apoptosis; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Cell Line, Tumor; Cel

2015
Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis.
    Cancer science, 2010, Volume: 101, Issue:5

    Topics: Apoptosis; Cantharidin; Cell Division; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; G2 P

2010
Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin.
    Cancer letters, 2010, Nov-28, Volume: 297, Issue:2

    Topics: Cantharidin; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhib

2010
PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway.
    Cancer letters, 2011, May-28, Volume: 304, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cantharidin; Cell Line, Tumor; Cell Survival; E

2011
Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:17

    Topics: Cantharidin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Enzyme Inhibito

2011