cantharidin has been researched along with Osteogenic Sarcoma in 2 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteosarcoma is the most common primary malignant bone tumor in children and adolescents." | 1.51 | Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma. ( He, M; Ji, XL, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, XL | 1 |
| He, M | 1 |
| Feng, S | 1 |
| Zhu, J | 1 |
| Xia, K | 1 |
| Yu, W | 1 |
| Wang, Y | 1 |
| Wang, J | 1 |
| Li, F | 1 |
| Yang, Z | 1 |
| Yang, X | 1 |
| Liu, B | 1 |
| Tao, H | 1 |
| Liang, C | 1 |
2 other studies available for cantharidin and Osteogenic Sarcoma
| Article | Year |
|---|---|
Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma.
Topics: Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Cant | 2019 |
Cantharidin Inhibits Anti-Apoptotic Bcl-2 Family Proteins and Induces Apoptosis in Human Osteosarcoma Cell Lines MG-63 and MNNG/HOS via Mitochondria-Dependent Pathway.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cantharidin; Cell Cycle; Cell Cycle Checkpoints; Cell Line | 2018 |