Page last updated: 2024-11-08

cantharidin and Neoplasms

cantharidin has been researched along with Neoplasms in 24 studies

Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"The pertinent anticancer strength of CTD could be employed to develop an effective anticarcinogenic drug."2.66Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways. ( Naz, F; Wu, Y; Yang, Z; Yu, C; Zhang, N, 2020)
"Norcantharidin (NCTD) is a structural modifier of CTD."2.66Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years. ( Cao, Z; Guo, C; Li, Y; Ren, Y; Song, X; Tan, L; Wang, M; Zhou, J, 2020)
"Recently, cancer affects people's life more and more."2.58Overview of Cantharidin and its Analogues. ( Deng, L; Dong, J; Wang, G, 2018)
"Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide."1.91Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1. ( Herrmann, P; Ishfaq, MA; Schöpe, PC; Shoemaker, RH; Smith, J; Stein, U; Walther, W; Zinnow, V, 2023)
" Here we use synthetic dosage lethality (SDL), where the overexpression of PLK1 is lethal only when another, normally non-lethal, mutation or deletion is present."1.43Therapeutic relevance of the protein phosphatase 2A in cancer. ( Abuhussein, O; Alli, N; Anderson, DH; Bhanumathy, KK; Bonham, K; Boyd, F; Cunningham, CE; El Zawily, AM; Freywald, A; Furber, L; Geyer, R; Lee, JS; Li, S; McDonald, M; Mousseau, DD; Parameswaran, S; Paul, JM; Ruppin, E; Sablina, A; Shukla, H; Templeton, SD; Uppalapati, M; Vizeacoumar, FJ; Vizeacoumar, FS; Weaver, BA; Yan, J; Yu-Lee, LY, 2016)
"To evaluate the efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions."1.42Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. ( Song, J; Wang, LZ; Zhang, HJ, 2015)
" Thus, we hypothesized that Mad2 overexpression could specifically make cancer cells susceptible to death by inducing a synthetic dosage lethality defect."1.40Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors. ( Bansal, PK; Bian, Y; Fujii, Y; Kitagawa, K; Kitagawa, R; Stepanov, A, 2014)
"The knock-out of HSF1 impairs cancer formation and progression, suggesting that HSF1 is a promising therapeutic target."1.39The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. ( Han, DC; Kim, JA; Kim, Y; Kwon, BM, 2013)
"The present work describes the anticancer activity of cantharidin isolated from red-headed blister beetles, Epicauta hirticornis and its possible mode of action involving induction of apoptosis, oxidative stress and decrease in glutathione against murine ascites Dalton's lymphoma."1.39Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis. ( Prasad, SB; Verma, AK, 2013)
"Treatment of norcantharidin with allylamine afforded the corresponding allyl-norcantharimide (20) which was amenable to epoxidation (mCPBA, 22) and subsequent ring opening (MeOH/H(+); 23) or alternatively, osmylation (OsO(4)/NMO; 24)."1.34Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. ( Ackland, SP; Gilbert, J; Hill, TA; McCluskey, A; Sakoff, JA; Sauer, B; Stewart, SG, 2007)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.50)18.7374
1990's0 (0.00)18.2507
2000's4 (16.67)29.6817
2010's14 (58.33)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Hill, TA1
Stewart, SG1
Ackland, SP3
Gilbert, J1
Sauer, B1
Sakoff, JA3
McCluskey, A3
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y2
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Schöpe, PC1
Zinnow, V1
Ishfaq, MA1
Smith, J1
Herrmann, P1
Shoemaker, RH1
Walther, W1
Stein, U1
Naz, F1
Wu, Y1
Zhang, N1
Yang, Z1
Yu, C1
Zhou, J1
Ren, Y1
Tan, L1
Song, X1
Wang, M1
Cao, Z1
Guo, C1
Wang, G1
Dong, J2
Deng, L1
Zhang, F1
Lin, QY1
Hu, WL1
Song, WJ1
Shen, ST1
Gui, P1
Puerto Galvis, CE1
Vargas Méndez, LY1
Kouznetsov, VV1
Kim, JA1
Kim, Y1
Kwon, BM1
Han, DC1
Wang, E1
Xiong, H1
Zhou, D1
Xie, Z1
Huang, Y1
Jing, X1
Sun, X1
Bian, Y1
Kitagawa, R1
Bansal, PK1
Fujii, Y1
Stepanov, A1
Kitagawa, K1
Wang, LZ1
Zhang, HJ1
Song, J1
Cunningham, CE1
Li, S1
Vizeacoumar, FS1
Bhanumathy, KK1
Lee, JS1
Parameswaran, S1
Furber, L1
Abuhussein, O1
Paul, JM1
McDonald, M1
Templeton, SD1
Shukla, H1
El Zawily, AM1
Boyd, F1
Alli, N1
Mousseau, DD1
Geyer, R1
Bonham, K1
Anderson, DH1
Yan, J1
Yu-Lee, LY1
Weaver, BA1
Uppalapati, M1
Ruppin, E1
Sablina, A1
Freywald, A1
Vizeacoumar, FJ1
Youns, M1
Hoheisel, JD1
Efferth, T1
Appelgren, LE1
Tseng, IJ1
Sheu, SY1
Chen, YT1
Huang, CY1
Lin, CT1
Lin, PY1
Deng, LP1
Cai, H1
Wang, W1
Verma, AK1
Prasad, SB1
Gardiner, E1
Walkom, CC2
Bowyer, MC1
Baldwin, ML1
Garner, J1
POUND, AW1
WITHERS, HR1
SKJAEGGESTAD, O1
Jiang, TL1
Salmon, SE1
Liu, RM1

Reviews

7 reviews available for cantharidin and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways.
    Molecules (Basel, Switzerland), 2020, Jul-19, Volume: 25, Issue:14

    Topics: Animals; Antineoplastic Agents; Cantharidin; Humans; Neoplasms; Signal Transduction

2020
Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Bridged Bicyclo Compounds, Heterocyclic; Canth

2020
Overview of Cantharidin and its Analogues.
    Current medicinal chemistry, 2018, Volume: 25, Issue:17

    Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Enzyme Inhibitors; Humans; Neoplasms;

2018
Cantharidin-based small molecules as potential therapeutic agents.
    Chemical biology & drug design, 2013, Volume: 82, Issue:5

    Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Cell Survival;

2013
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
    Current drug discovery technologies, 2010, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Arsenic Trioxide; Arsenicals; Artemisinins; Artesunate;

2010
Cantharidin as an antitumor agent: a retrospective review.
    Current medicinal chemistry, 2013, Volume: 20, Issue:2

    Topics: Antineoplastic Agents; Cantharidin; Humans; Medicine, Chinese Traditional; Neoplasms

2013

Other Studies

17 other studies available for cantharidin and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.
    Bioorganic & medicinal chemistry, 2007, Sep-15, Volume: 15, Issue:18

    Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Hu

2007
Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1.
    International journal of molecular sciences, 2023, Jan-07, Volume: 24, Issue:2

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Colorectal Neoplasms; Humans; Neoplasms; S100

2023
Interaction with biomacromolecules and antiproliferative activities of Mn(II), Ni(II), Zn(II) complexes of demethylcantharate and 2,2'-bipyridine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Volume: 110

    Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Cantharidin; Cattle; Cell Line, Tumor; Cell Prolifer

2013
The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters.
    The Journal of biological chemistry, 2013, Oct-04, Volume: 288, Issue:40

    Topics: Acetylation; Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; bcl-X Protein; Can

2013
Co-delivery of oxaliplatin and demethylcantharidin via a polymer-drug conjugate.
    Macromolecular bioscience, 2014, Volume: 14, Issue:4

    Topics: Cantharidin; Cell Line, Tumor; Humans; Micelles; Microscopy, Confocal; Neoplasms; Organoplatinum Com

2014
Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-28, Volume: 111, Issue:4

    Topics: Base Sequence; Cantharidin; DNA Primers; Enzyme Inhibitors; Gene Knockdown Techniques; HeLa Cells; H

2014
Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Cantharidin; Case-Control Studies; Cisplatin; Drug Therapy, Comb

2015
Therapeutic relevance of the protein phosphatase 2A in cancer.
    Oncotarget, 2016, Sep-20, Volume: 7, Issue:38

    Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Cell Cycle Proteins; Chromosomal Instability; Enzyme

2016
Spanish flies in the veterinary pharmacy in Skara--their medicinal use yesterday and to day.
    Historia medicinae veterinariae, 2010, Volume: 35, Issue:2

    Topics: Animals; Antineoplastic Agents; Aphrodisiacs; Cantharidin; Coleoptera; History, 18th Century; Histor

2010
A simple procedure for preparation of N-thiazol, thiadiazol, pyridyl and sulfanylamidocantharidinimines analogues and evaluation of their cytotoxicities against human HL-60, MCF7, Neuro-2a and A549 carcinoma cell.
    Chemical & pharmaceutical bulletin, 2012, Volume: 60, Issue:11

    Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Cell Proliferation; Cell Survival; HL

2012
Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis.
    Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Cell Line, Tumor; Coleoptera; Crystallograph

2013
The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?
    Anti-cancer drug design, 2001, Volume: 16, Issue:6

    Topics: Antineoplastic Agents; Cantharidin; Drug Design; Enzyme Inhibitors; Models, Molecular; Molecular Str

2001
Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.
    Bioorganic chemistry, 2003, Volume: 31, Issue:1

    Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Division; Cell Line, Tumor; Drug Screening Assays,

2003
THE INFLUENCE OF SOME IRRITANT CHEMICALS AND SCARIFICATION ON TUMOUR INITIATION BY URETHANE IN MICE.
    British journal of cancer, 1963, Volume: 17

    Topics: Acetates; Acetone; Cantharidin; Cell Transformation, Neoplastic; Dermabrasion; Iodoacetates; Irritan

1963
EXPERIMENTAL EPIDERMAL HYPERPLASIA IN MICE: RELATION TO CARCINOGENESIS.
    Acta pathologica et microbiologica Scandinavica. Supplementum, 1964

    Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cantharidin; Carcinogenesis; Carcinogens; Cell Division;

1964
Activity of camptothecin, harringtonin, cantharidin and curcumae in the human tumor stem cell assay.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:2

    Topics: Alkaloids; Antineoplastic Agents; Camptothecin; Cantharidin; Catechols; Cell Survival; Colony-Formin

1983