cantharidin has been researched along with Neoplasms in 24 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pertinent anticancer strength of CTD could be employed to develop an effective anticarcinogenic drug." | 2.66 | Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways. ( Naz, F; Wu, Y; Yang, Z; Yu, C; Zhang, N, 2020) |
| "Norcantharidin (NCTD) is a structural modifier of CTD." | 2.66 | Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years. ( Cao, Z; Guo, C; Li, Y; Ren, Y; Song, X; Tan, L; Wang, M; Zhou, J, 2020) |
| "Recently, cancer affects people's life more and more." | 2.58 | Overview of Cantharidin and its Analogues. ( Deng, L; Dong, J; Wang, G, 2018) |
| "Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide." | 1.91 | Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1. ( Herrmann, P; Ishfaq, MA; Schöpe, PC; Shoemaker, RH; Smith, J; Stein, U; Walther, W; Zinnow, V, 2023) |
| " Here we use synthetic dosage lethality (SDL), where the overexpression of PLK1 is lethal only when another, normally non-lethal, mutation or deletion is present." | 1.43 | Therapeutic relevance of the protein phosphatase 2A in cancer. ( Abuhussein, O; Alli, N; Anderson, DH; Bhanumathy, KK; Bonham, K; Boyd, F; Cunningham, CE; El Zawily, AM; Freywald, A; Furber, L; Geyer, R; Lee, JS; Li, S; McDonald, M; Mousseau, DD; Parameswaran, S; Paul, JM; Ruppin, E; Sablina, A; Shukla, H; Templeton, SD; Uppalapati, M; Vizeacoumar, FJ; Vizeacoumar, FS; Weaver, BA; Yan, J; Yu-Lee, LY, 2016) |
| "To evaluate the efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions." | 1.42 | Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. ( Song, J; Wang, LZ; Zhang, HJ, 2015) |
| " Thus, we hypothesized that Mad2 overexpression could specifically make cancer cells susceptible to death by inducing a synthetic dosage lethality defect." | 1.40 | Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors. ( Bansal, PK; Bian, Y; Fujii, Y; Kitagawa, K; Kitagawa, R; Stepanov, A, 2014) |
| "The knock-out of HSF1 impairs cancer formation and progression, suggesting that HSF1 is a promising therapeutic target." | 1.39 | The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. ( Han, DC; Kim, JA; Kim, Y; Kwon, BM, 2013) |
| "The present work describes the anticancer activity of cantharidin isolated from red-headed blister beetles, Epicauta hirticornis and its possible mode of action involving induction of apoptosis, oxidative stress and decrease in glutathione against murine ascites Dalton's lymphoma." | 1.39 | Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis. ( Prasad, SB; Verma, AK, 2013) |
| "Treatment of norcantharidin with allylamine afforded the corresponding allyl-norcantharimide (20) which was amenable to epoxidation (mCPBA, 22) and subsequent ring opening (MeOH/H(+); 23) or alternatively, osmylation (OsO(4)/NMO; 24)." | 1.34 | Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. ( Ackland, SP; Gilbert, J; Hill, TA; McCluskey, A; Sakoff, JA; Sauer, B; Stewart, SG, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Hill, TA | 1 |
| Stewart, SG | 1 |
| Ackland, SP | 3 |
| Gilbert, J | 1 |
| Sauer, B | 1 |
| Sakoff, JA | 3 |
| McCluskey, A | 3 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 2 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Schöpe, PC | 1 |
| Zinnow, V | 1 |
| Ishfaq, MA | 1 |
| Smith, J | 1 |
| Herrmann, P | 1 |
| Shoemaker, RH | 1 |
| Walther, W | 1 |
| Stein, U | 1 |
| Naz, F | 1 |
| Wu, Y | 1 |
| Zhang, N | 1 |
| Yang, Z | 1 |
| Yu, C | 1 |
| Zhou, J | 1 |
| Ren, Y | 1 |
| Tan, L | 1 |
| Song, X | 1 |
| Wang, M | 1 |
| Cao, Z | 1 |
| Guo, C | 1 |
| Wang, G | 1 |
| Dong, J | 2 |
| Deng, L | 1 |
| Zhang, F | 1 |
| Lin, QY | 1 |
| Hu, WL | 1 |
| Song, WJ | 1 |
| Shen, ST | 1 |
| Gui, P | 1 |
| Puerto Galvis, CE | 1 |
| Vargas Méndez, LY | 1 |
| Kouznetsov, VV | 1 |
| Kim, JA | 1 |
| Kim, Y | 1 |
| Kwon, BM | 1 |
| Han, DC | 1 |
| Wang, E | 1 |
| Xiong, H | 1 |
| Zhou, D | 1 |
| Xie, Z | 1 |
| Huang, Y | 1 |
| Jing, X | 1 |
| Sun, X | 1 |
| Bian, Y | 1 |
| Kitagawa, R | 1 |
| Bansal, PK | 1 |
| Fujii, Y | 1 |
| Stepanov, A | 1 |
| Kitagawa, K | 1 |
| Wang, LZ | 1 |
| Zhang, HJ | 1 |
| Song, J | 1 |
| Cunningham, CE | 1 |
| Li, S | 1 |
| Vizeacoumar, FS | 1 |
| Bhanumathy, KK | 1 |
| Lee, JS | 1 |
| Parameswaran, S | 1 |
| Furber, L | 1 |
| Abuhussein, O | 1 |
| Paul, JM | 1 |
| McDonald, M | 1 |
| Templeton, SD | 1 |
| Shukla, H | 1 |
| El Zawily, AM | 1 |
| Boyd, F | 1 |
| Alli, N | 1 |
| Mousseau, DD | 1 |
| Geyer, R | 1 |
| Bonham, K | 1 |
| Anderson, DH | 1 |
| Yan, J | 1 |
| Yu-Lee, LY | 1 |
| Weaver, BA | 1 |
| Uppalapati, M | 1 |
| Ruppin, E | 1 |
| Sablina, A | 1 |
| Freywald, A | 1 |
| Vizeacoumar, FJ | 1 |
| Youns, M | 1 |
| Hoheisel, JD | 1 |
| Efferth, T | 1 |
| Appelgren, LE | 1 |
| Tseng, IJ | 1 |
| Sheu, SY | 1 |
| Chen, YT | 1 |
| Huang, CY | 1 |
| Lin, CT | 1 |
| Lin, PY | 1 |
| Deng, LP | 1 |
| Cai, H | 1 |
| Wang, W | 1 |
| Verma, AK | 1 |
| Prasad, SB | 1 |
| Gardiner, E | 1 |
| Walkom, CC | 2 |
| Bowyer, MC | 1 |
| Baldwin, ML | 1 |
| Garner, J | 1 |
| POUND, AW | 1 |
| WITHERS, HR | 1 |
| SKJAEGGESTAD, O | 1 |
| Jiang, TL | 1 |
| Salmon, SE | 1 |
| Liu, RM | 1 |
7 reviews available for cantharidin and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways.
Topics: Animals; Antineoplastic Agents; Cantharidin; Humans; Neoplasms; Signal Transduction | 2020 |
Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Bridged Bicyclo Compounds, Heterocyclic; Canth | 2020 |
Overview of Cantharidin and its Analogues.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Enzyme Inhibitors; Humans; Neoplasms; | 2018 |
Cantharidin-based small molecules as potential therapeutic agents.
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Cell Survival; | 2013 |
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arsenic Trioxide; Arsenicals; Artemisinins; Artesunate; | 2010 |
Cantharidin as an antitumor agent: a retrospective review.
Topics: Antineoplastic Agents; Cantharidin; Humans; Medicine, Chinese Traditional; Neoplasms | 2013 |
17 other studies available for cantharidin and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Hu | 2007 |
Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Colorectal Neoplasms; Humans; Neoplasms; S100 | 2023 |
Interaction with biomacromolecules and antiproliferative activities of Mn(II), Ni(II), Zn(II) complexes of demethylcantharate and 2,2'-bipyridine.
Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Cantharidin; Cattle; Cell Line, Tumor; Cell Prolifer | 2013 |
The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; bcl-X Protein; Can | 2013 |
Co-delivery of oxaliplatin and demethylcantharidin via a polymer-drug conjugate.
Topics: Cantharidin; Cell Line, Tumor; Humans; Micelles; Microscopy, Confocal; Neoplasms; Organoplatinum Com | 2014 |
Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors.
Topics: Base Sequence; Cantharidin; DNA Primers; Enzyme Inhibitors; Gene Knockdown Techniques; HeLa Cells; H | 2014 |
Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions.
Topics: Adult; Aged; Antineoplastic Agents; Cantharidin; Case-Control Studies; Cisplatin; Drug Therapy, Comb | 2015 |
Therapeutic relevance of the protein phosphatase 2A in cancer.
Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Cell Cycle Proteins; Chromosomal Instability; Enzyme | 2016 |
Spanish flies in the veterinary pharmacy in Skara--their medicinal use yesterday and to day.
Topics: Animals; Antineoplastic Agents; Aphrodisiacs; Cantharidin; Coleoptera; History, 18th Century; Histor | 2010 |
A simple procedure for preparation of N-thiazol, thiadiazol, pyridyl and sulfanylamidocantharidinimines analogues and evaluation of their cytotoxicities against human HL-60, MCF7, Neuro-2a and A549 carcinoma cell.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Cell Proliferation; Cell Survival; HL | 2012 |
Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Cell Line, Tumor; Coleoptera; Crystallograph | 2013 |
The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?
Topics: Antineoplastic Agents; Cantharidin; Drug Design; Enzyme Inhibitors; Models, Molecular; Molecular Str | 2001 |
Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Division; Cell Line, Tumor; Drug Screening Assays, | 2003 |
THE INFLUENCE OF SOME IRRITANT CHEMICALS AND SCARIFICATION ON TUMOUR INITIATION BY URETHANE IN MICE.
Topics: Acetates; Acetone; Cantharidin; Cell Transformation, Neoplastic; Dermabrasion; Iodoacetates; Irritan | 1963 |
EXPERIMENTAL EPIDERMAL HYPERPLASIA IN MICE: RELATION TO CARCINOGENESIS.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cantharidin; Carcinogenesis; Carcinogens; Cell Division; | 1964 |
Activity of camptothecin, harringtonin, cantharidin and curcumae in the human tumor stem cell assay.
Topics: Alkaloids; Antineoplastic Agents; Camptothecin; Cantharidin; Catechols; Cell Survival; Colony-Formin | 1983 |