cantharidin has been researched along with Neoplasms in 24 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Excerpt | Relevance | Reference |
---|---|---|
"The pertinent anticancer strength of CTD could be employed to develop an effective anticarcinogenic drug." | 2.66 | Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways. ( Naz, F; Wu, Y; Yang, Z; Yu, C; Zhang, N, 2020) |
"Norcantharidin (NCTD) is a structural modifier of CTD." | 2.66 | Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years. ( Cao, Z; Guo, C; Li, Y; Ren, Y; Song, X; Tan, L; Wang, M; Zhou, J, 2020) |
"Recently, cancer affects people's life more and more." | 2.58 | Overview of Cantharidin and its Analogues. ( Deng, L; Dong, J; Wang, G, 2018) |
"Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide." | 1.91 | Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1. ( Herrmann, P; Ishfaq, MA; Schöpe, PC; Shoemaker, RH; Smith, J; Stein, U; Walther, W; Zinnow, V, 2023) |
" Here we use synthetic dosage lethality (SDL), where the overexpression of PLK1 is lethal only when another, normally non-lethal, mutation or deletion is present." | 1.43 | Therapeutic relevance of the protein phosphatase 2A in cancer. ( Abuhussein, O; Alli, N; Anderson, DH; Bhanumathy, KK; Bonham, K; Boyd, F; Cunningham, CE; El Zawily, AM; Freywald, A; Furber, L; Geyer, R; Lee, JS; Li, S; McDonald, M; Mousseau, DD; Parameswaran, S; Paul, JM; Ruppin, E; Sablina, A; Shukla, H; Templeton, SD; Uppalapati, M; Vizeacoumar, FJ; Vizeacoumar, FS; Weaver, BA; Yan, J; Yu-Lee, LY, 2016) |
"To evaluate the efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions." | 1.42 | Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions. ( Song, J; Wang, LZ; Zhang, HJ, 2015) |
" Thus, we hypothesized that Mad2 overexpression could specifically make cancer cells susceptible to death by inducing a synthetic dosage lethality defect." | 1.40 | Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors. ( Bansal, PK; Bian, Y; Fujii, Y; Kitagawa, K; Kitagawa, R; Stepanov, A, 2014) |
"The knock-out of HSF1 impairs cancer formation and progression, suggesting that HSF1 is a promising therapeutic target." | 1.39 | The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. ( Han, DC; Kim, JA; Kim, Y; Kwon, BM, 2013) |
"The present work describes the anticancer activity of cantharidin isolated from red-headed blister beetles, Epicauta hirticornis and its possible mode of action involving induction of apoptosis, oxidative stress and decrease in glutathione against murine ascites Dalton's lymphoma." | 1.39 | Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis. ( Prasad, SB; Verma, AK, 2013) |
"Treatment of norcantharidin with allylamine afforded the corresponding allyl-norcantharimide (20) which was amenable to epoxidation (mCPBA, 22) and subsequent ring opening (MeOH/H(+); 23) or alternatively, osmylation (OsO(4)/NMO; 24)." | 1.34 | Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. ( Ackland, SP; Gilbert, J; Hill, TA; McCluskey, A; Sakoff, JA; Sauer, B; Stewart, SG, 2007) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (12.50) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (16.67) | 29.6817 |
2010's | 14 (58.33) | 24.3611 |
2020's | 3 (12.50) | 2.80 |
Authors | Studies |
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Diamandis, P | 1 |
Wildenhain, J | 1 |
Clarke, ID | 1 |
Sacher, AG | 1 |
Graham, J | 1 |
Bellows, DS | 1 |
Ling, EK | 1 |
Ward, RJ | 1 |
Jamieson, LG | 1 |
Tyers, M | 1 |
Dirks, PB | 1 |
Hill, TA | 1 |
Stewart, SG | 1 |
Ackland, SP | 3 |
Gilbert, J | 1 |
Sauer, B | 1 |
Sakoff, JA | 3 |
McCluskey, A | 3 |
Lin, R | 1 |
Elf, S | 1 |
Shan, C | 1 |
Kang, HB | 1 |
Ji, Q | 1 |
Zhou, L | 1 |
Hitosugi, T | 1 |
Zhang, L | 1 |
Zhang, S | 1 |
Seo, JH | 1 |
Xie, J | 1 |
Tucker, M | 1 |
Gu, TL | 1 |
Sudderth, J | 1 |
Jiang, L | 1 |
Mitsche, M | 1 |
DeBerardinis, RJ | 1 |
Wu, S | 1 |
Li, Y | 2 |
Mao, H | 1 |
Chen, PR | 1 |
Wang, D | 1 |
Chen, GZ | 1 |
Hurwitz, SJ | 1 |
Lonial, S | 1 |
Arellano, ML | 1 |
Khoury, HJ | 1 |
Khuri, FR | 1 |
Lee, BH | 1 |
Lei, Q | 1 |
Brat, DJ | 1 |
Ye, K | 1 |
Boggon, TJ | 1 |
He, C | 1 |
Kang, S | 1 |
Fan, J | 1 |
Chen, J | 1 |
Schöpe, PC | 1 |
Zinnow, V | 1 |
Ishfaq, MA | 1 |
Smith, J | 1 |
Herrmann, P | 1 |
Shoemaker, RH | 1 |
Walther, W | 1 |
Stein, U | 1 |
Naz, F | 1 |
Wu, Y | 1 |
Zhang, N | 1 |
Yang, Z | 1 |
Yu, C | 1 |
Zhou, J | 1 |
Ren, Y | 1 |
Tan, L | 1 |
Song, X | 1 |
Wang, M | 1 |
Cao, Z | 1 |
Guo, C | 1 |
Wang, G | 1 |
Dong, J | 2 |
Deng, L | 1 |
Zhang, F | 1 |
Lin, QY | 1 |
Hu, WL | 1 |
Song, WJ | 1 |
Shen, ST | 1 |
Gui, P | 1 |
Puerto Galvis, CE | 1 |
Vargas Méndez, LY | 1 |
Kouznetsov, VV | 1 |
Kim, JA | 1 |
Kim, Y | 1 |
Kwon, BM | 1 |
Han, DC | 1 |
Wang, E | 1 |
Xiong, H | 1 |
Zhou, D | 1 |
Xie, Z | 1 |
Huang, Y | 1 |
Jing, X | 1 |
Sun, X | 1 |
Bian, Y | 1 |
Kitagawa, R | 1 |
Bansal, PK | 1 |
Fujii, Y | 1 |
Stepanov, A | 1 |
Kitagawa, K | 1 |
Wang, LZ | 1 |
Zhang, HJ | 1 |
Song, J | 1 |
Cunningham, CE | 1 |
Li, S | 1 |
Vizeacoumar, FS | 1 |
Bhanumathy, KK | 1 |
Lee, JS | 1 |
Parameswaran, S | 1 |
Furber, L | 1 |
Abuhussein, O | 1 |
Paul, JM | 1 |
McDonald, M | 1 |
Templeton, SD | 1 |
Shukla, H | 1 |
El Zawily, AM | 1 |
Boyd, F | 1 |
Alli, N | 1 |
Mousseau, DD | 1 |
Geyer, R | 1 |
Bonham, K | 1 |
Anderson, DH | 1 |
Yan, J | 1 |
Yu-Lee, LY | 1 |
Weaver, BA | 1 |
Uppalapati, M | 1 |
Ruppin, E | 1 |
Sablina, A | 1 |
Freywald, A | 1 |
Vizeacoumar, FJ | 1 |
Youns, M | 1 |
Hoheisel, JD | 1 |
Efferth, T | 1 |
Appelgren, LE | 1 |
Tseng, IJ | 1 |
Sheu, SY | 1 |
Chen, YT | 1 |
Huang, CY | 1 |
Lin, CT | 1 |
Lin, PY | 1 |
Deng, LP | 1 |
Cai, H | 1 |
Wang, W | 1 |
Verma, AK | 1 |
Prasad, SB | 1 |
Gardiner, E | 1 |
Walkom, CC | 2 |
Bowyer, MC | 1 |
Baldwin, ML | 1 |
Garner, J | 1 |
POUND, AW | 1 |
WITHERS, HR | 1 |
SKJAEGGESTAD, O | 1 |
Jiang, TL | 1 |
Salmon, SE | 1 |
Liu, RM | 1 |
7 reviews available for cantharidin and Neoplasms
Article | Year |
---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways.
Topics: Animals; Antineoplastic Agents; Cantharidin; Humans; Neoplasms; Signal Transduction | 2020 |
Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Bridged Bicyclo Compounds, Heterocyclic; Canth | 2020 |
Overview of Cantharidin and its Analogues.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Enzyme Inhibitors; Humans; Neoplasms; | 2018 |
Cantharidin-based small molecules as potential therapeutic agents.
Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Cell Survival; | 2013 |
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
Topics: Animals; Antineoplastic Agents, Phytogenic; Arsenic Trioxide; Arsenicals; Artemisinins; Artesunate; | 2010 |
Cantharidin as an antitumor agent: a retrospective review.
Topics: Antineoplastic Agents; Cantharidin; Humans; Medicine, Chinese Traditional; Neoplasms | 2013 |
17 other studies available for cantharidin and Neoplasms
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Hu | 2007 |
Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Colorectal Neoplasms; Humans; Neoplasms; S100 | 2023 |
Interaction with biomacromolecules and antiproliferative activities of Mn(II), Ni(II), Zn(II) complexes of demethylcantharate and 2,2'-bipyridine.
Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Cantharidin; Cattle; Cell Line, Tumor; Cell Prolifer | 2013 |
The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; bcl-X Protein; Can | 2013 |
Co-delivery of oxaliplatin and demethylcantharidin via a polymer-drug conjugate.
Topics: Cantharidin; Cell Line, Tumor; Humans; Micelles; Microscopy, Confocal; Neoplasms; Organoplatinum Com | 2014 |
Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors.
Topics: Base Sequence; Cantharidin; DNA Primers; Enzyme Inhibitors; Gene Knockdown Techniques; HeLa Cells; H | 2014 |
Efficacy of mannatide combined with sodium cantharidate vitamin B6 in the treatment of malignant pleural effusions.
Topics: Adult; Aged; Antineoplastic Agents; Cantharidin; Case-Control Studies; Cisplatin; Drug Therapy, Comb | 2015 |
Therapeutic relevance of the protein phosphatase 2A in cancer.
Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Cell Cycle Proteins; Chromosomal Instability; Enzyme | 2016 |
Spanish flies in the veterinary pharmacy in Skara--their medicinal use yesterday and to day.
Topics: Animals; Antineoplastic Agents; Aphrodisiacs; Cantharidin; Coleoptera; History, 18th Century; Histor | 2010 |
A simple procedure for preparation of N-thiazol, thiadiazol, pyridyl and sulfanylamidocantharidinimines analogues and evaluation of their cytotoxicities against human HL-60, MCF7, Neuro-2a and A549 carcinoma cell.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Cell Proliferation; Cell Survival; HL | 2012 |
Changes in glutathione, oxidative stress and mitochondrial membrane potential in apoptosis involving the anticancer activity of cantharidin isolated from redheaded blister beetles, epicauta hirticornis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Cell Line, Tumor; Coleoptera; Crystallograph | 2013 |
The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?
Topics: Antineoplastic Agents; Cantharidin; Drug Design; Enzyme Inhibitors; Models, Molecular; Molecular Str | 2001 |
Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cell Division; Cell Line, Tumor; Drug Screening Assays, | 2003 |
THE INFLUENCE OF SOME IRRITANT CHEMICALS AND SCARIFICATION ON TUMOUR INITIATION BY URETHANE IN MICE.
Topics: Acetates; Acetone; Cantharidin; Cell Transformation, Neoplastic; Dermabrasion; Iodoacetates; Irritan | 1963 |
EXPERIMENTAL EPIDERMAL HYPERPLASIA IN MICE: RELATION TO CARCINOGENESIS.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cantharidin; Carcinogenesis; Carcinogens; Cell Division; | 1964 |
Activity of camptothecin, harringtonin, cantharidin and curcumae in the human tumor stem cell assay.
Topics: Alkaloids; Antineoplastic Agents; Camptothecin; Cantharidin; Catechols; Cell Survival; Colony-Formin | 1983 |