cantharidin has been researched along with Mesothelioma in 1 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lovastatin showed no cytotoxicity in mesothelioma or pancreatic carcinoma cells at concentrations up to 10 μM and pH around 7." | 3.76 | Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin. ( Chiba, Y; Fukamachi, T; Kobayashi, H; Saito, H; Tagawa, M; Wang, X, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukamachi, T | 1 |
| Chiba, Y | 1 |
| Wang, X | 1 |
| Saito, H | 1 |
| Tagawa, M | 1 |
| Kobayashi, H | 1 |
1 other study available for cantharidin and Mesothelioma
| Article | Year |
|---|---|
Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin.
Topics: Cantharidin; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhib | 2010 |