cantharidin has been researched along with Melanoma in 3 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Excerpt | Relevance | Reference |
---|---|---|
"Melanoma is a highly important metastasis in human cancer." | 5.42 | Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015) |
"Melanoma is a highly important metastasis in human cancer." | 1.42 | Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Mu, Z | 1 |
Sun, Q | 1 |
Hsiao, YP | 2 |
Tsai, CH | 2 |
Wu, PP | 1 |
Hsu, SC | 2 |
Liu, HC | 2 |
Huang, YP | 2 |
Yang, JH | 1 |
Chung, JG | 2 |
Ji, BC | 1 |
Chang, SJ | 1 |
Lien, JC | 1 |
3 other studies available for cantharidin and Melanoma
Article | Year |
---|---|
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Topics: Apoptosis; Cantharidin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulat | 2018 |
Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells.
Topics: Apoptosis; Cantharidin; cdc25 Phosphatases; Cell Line, Tumor; Cyclin A; Endoplasmic Reticulum Chaper | 2014 |
Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways.
Topics: Cantharidin; Cell Line, Tumor; Cell Movement; Humans; Matrix Metalloproteinase 2; Matrix Metalloprot | 2015 |