Page last updated: 2024-11-08

cantharidin and Melanoma

cantharidin has been researched along with Melanoma in 3 studies

Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Melanoma is a highly important metastasis in human cancer."5.42Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015)
"Melanoma is a highly important metastasis in human cancer."1.42Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mu, Z1
Sun, Q1
Hsiao, YP2
Tsai, CH2
Wu, PP1
Hsu, SC2
Liu, HC2
Huang, YP2
Yang, JH1
Chung, JG2
Ji, BC1
Chang, SJ1
Lien, JC1

Other Studies

3 other studies available for cantharidin and Melanoma

ArticleYear
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
    Molecular medicine reports, 2018, Volume: 18, Issue:5

    Topics: Apoptosis; Cantharidin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulat

2018
Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells.
    International journal of oncology, 2014, Volume: 45, Issue:6

    Topics: Apoptosis; Cantharidin; cdc25 Phosphatases; Cell Line, Tumor; Cyclin A; Endoplasmic Reticulum Chaper

2014
Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways.
    Anticancer research, 2015, Volume: 35, Issue:2

    Topics: Cantharidin; Cell Line, Tumor; Cell Movement; Humans; Matrix Metalloproteinase 2; Matrix Metalloprot

2015