cantharidin has been researched along with Malignant Melanoma in 3 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melanoma is a highly important metastasis in human cancer." | 5.42 | Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015) |
| "Melanoma is a highly important metastasis in human cancer." | 1.42 | Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mu, Z | 1 |
| Sun, Q | 1 |
| Hsiao, YP | 2 |
| Tsai, CH | 2 |
| Wu, PP | 1 |
| Hsu, SC | 2 |
| Liu, HC | 2 |
| Huang, YP | 2 |
| Yang, JH | 1 |
| Chung, JG | 2 |
| Ji, BC | 1 |
| Chang, SJ | 1 |
| Lien, JC | 1 |
3 other studies available for cantharidin and Malignant Melanoma
| Article | Year |
|---|---|
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Topics: Apoptosis; Cantharidin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulat | 2018 |
Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells.
Topics: Apoptosis; Cantharidin; cdc25 Phosphatases; Cell Line, Tumor; Cyclin A; Endoplasmic Reticulum Chaper | 2014 |
Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways.
Topics: Cantharidin; Cell Line, Tumor; Cell Movement; Humans; Matrix Metalloproteinase 2; Matrix Metalloprot | 2015 |