cantharidin has been researched along with Leukemia in 2 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A novel series of TCM-platinum complexes [Pt(C8H8O5)(NH2R)2] 1-5, designed from incorporating demethylcantharidin, a modified component from a traditional Chinese medicine (TCM) with a platinum moiety was found to circumvent cisplatin resistance in mouse leukemia and human hepatocellular carcinoma." | 3.73 | Synergistic interaction between platinum-based antitumor agents and demethylcantharidin. ( Au-Yeung, SC; Ho, YP; To, KK, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, JP | 1 |
| Ying, K | 1 |
| Xiao, ZY | 1 |
| Zhou, B | 1 |
| Huang, QS | 1 |
| Wu, HM | 1 |
| Yin, M | 1 |
| Xie, Y | 1 |
| Mao, YM | 1 |
| Rui, YC | 1 |
| To, KK | 1 |
| Ho, YP | 1 |
| Au-Yeung, SC | 1 |
2 other studies available for cantharidin and Leukemia
| Article | Year |
|---|---|
Analysis of gene expression profiles in human HL-60 cell exposed to cantharidin using cDNA microarray.
Topics: Cantharidin; Cell Division; Enzyme Inhibitors; Gene Expression Profiling; HL-60 Cells; Humans; Leuke | 2004 |
Synergistic interaction between platinum-based antitumor agents and demethylcantharidin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Body Weight; Cantharidin; Carboplatin; Carcin | 2005 |