cantharidin has been researched along with Leucocythaemia in 2 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A novel series of TCM-platinum complexes [Pt(C8H8O5)(NH2R)2] 1-5, designed from incorporating demethylcantharidin, a modified component from a traditional Chinese medicine (TCM) with a platinum moiety was found to circumvent cisplatin resistance in mouse leukemia and human hepatocellular carcinoma." | 3.73 | Synergistic interaction between platinum-based antitumor agents and demethylcantharidin. ( Au-Yeung, SC; Ho, YP; To, KK, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, JP | 1 |
| Ying, K | 1 |
| Xiao, ZY | 1 |
| Zhou, B | 1 |
| Huang, QS | 1 |
| Wu, HM | 1 |
| Yin, M | 1 |
| Xie, Y | 1 |
| Mao, YM | 1 |
| Rui, YC | 1 |
| To, KK | 1 |
| Ho, YP | 1 |
| Au-Yeung, SC | 1 |
2 other studies available for cantharidin and Leucocythaemia
| Article | Year |
|---|---|
Analysis of gene expression profiles in human HL-60 cell exposed to cantharidin using cDNA microarray.
Topics: Cantharidin; Cell Division; Enzyme Inhibitors; Gene Expression Profiling; HL-60 Cells; Humans; Leuke | 2004 |
Synergistic interaction between platinum-based antitumor agents and demethylcantharidin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Body Weight; Cantharidin; Carboplatin; Carcin | 2005 |