cantharidin has been researched along with Invasiveness, Neoplasm in 8 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melanoma is a highly important metastasis in human cancer." | 5.42 | Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015) |
| " The present study aimed to investigate the molecular events underlying inhibitory effect of N-benzylcantharidinamide, a novel synthetic analog of cantharidin, on matrix metalloproteinase-9 (MMP-9)-mediated invasion in highly metastatic hepatocellular carcinoma Hep3B cells." | 3.80 | A novel cantharidin analog N-benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR. ( Choi, HJ; Choi, JY; Chung, TW; Eun, JS; Ha, KT; Han, CW; Han, YT; Jeong, HS; Kim, SY; Lee, CH; Lee, JY, 2014) |
| "Melanoma is a highly important metastasis in human cancer." | 1.42 | Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. ( Chang, SJ; Chung, JG; Hsiao, YP; Hsu, SC; Huang, YP; Ji, BC; Lien, JC; Liu, HC; Tsai, CH, 2015) |
| " Adverse effects on the gastrointestinal tract also were lower than in controls (p<0." | 1.40 | Safety of Brucea javanica and cantharidin combined with chemotherapy for treatment of NSCLC patients. ( Huang, XE; Ji, ZQ; Liu, J; Tang, JH; Wang, L; Wu, XY, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Li, S | 1 |
| Pang, J | 1 |
| Huang, F | 1 |
| Guo, B | 1 |
| Liu, H | 1 |
| Kim, YM | 1 |
| Ku, MJ | 1 |
| Son, YJ | 1 |
| Yun, JM | 1 |
| Kim, SH | 1 |
| Lee, SY | 1 |
| Lee, JY | 1 |
| Chung, TW | 1 |
| Choi, HJ | 1 |
| Lee, CH | 1 |
| Eun, JS | 1 |
| Han, YT | 1 |
| Choi, JY | 1 |
| Kim, SY | 1 |
| Han, CW | 1 |
| Jeong, HS | 1 |
| Ha, KT | 1 |
| Ji, ZQ | 1 |
| Huang, XE | 1 |
| Wu, XY | 1 |
| Liu, J | 1 |
| Wang, L | 1 |
| Tang, JH | 1 |
| Ji, BC | 1 |
| Hsiao, YP | 1 |
| Tsai, CH | 1 |
| Chang, SJ | 2 |
| Hsu, SC | 1 |
| Liu, HC | 1 |
| Huang, YP | 2 |
| Lien, JC | 1 |
| Chung, JG | 2 |
| Shen, M | 1 |
| Wu, MY | 1 |
| Chen, LP | 1 |
| Zhi, Q | 1 |
| Gong, FR | 1 |
| Chen, K | 1 |
| Li, DM | 1 |
| Wu, Y | 1 |
| Tao, M | 1 |
| Li, W | 1 |
| Hsia, TC | 1 |
| Yu, CC | 1 |
| Hsiao, YT | 1 |
| Wu, SH | 1 |
| Bau, DT | 1 |
| Lu, HF | 1 |
| Lin, JG | 1 |
| He, TP | 1 |
| Mo, LE | 1 |
| Liang, NC | 1 |
8 other studies available for cantharidin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
[Alkaline processing of cantharidin can significanty improve the antitumor activity of cantharidin].
Topics: Cantharidin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neop | 2020 |
Anti-metastatic effect of cantharidin in A549 human lung cancer cells.
Topics: Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Dru | 2013 |
A novel cantharidin analog N-benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR.
Topics: Cantharidin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosol; ELAV Proteins; Humans; Imides; Li | 2014 |
Safety of Brucea javanica and cantharidin combined with chemotherapy for treatment of NSCLC patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brucea; Cantharidin; | 2014 |
Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways.
Topics: Cantharidin; Cell Line, Tumor; Cell Movement; Humans; Matrix Metalloproteinase 2; Matrix Metalloprot | 2015 |
Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.
Topics: Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Repre | 2015 |
Cantharidin Impairs Cell Migration and Invasion of Human Lung Cancer NCI-H460 Cells via UPA and MAPK Signaling Pathways.
Topics: Cantharidin; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Humans; Lung Neoplasms; MAP Kinase | 2016 |
[Inhibitory effect of cantharidin on invasion and metastasis of highly metastatic ovarian carcinoma cell line HO-8910PM].
Topics: Antineoplastic Agents; Cantharidin; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferati | 2005 |