cantharidin has been researched along with Disease Models, Animal in 8 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The most common arrhythmias associated with the high doses of cantharidin were frequent ventricular ectopics, ventricular tachycardia, ventricular fibrillation or asytole." | 5.26 | A model of cardiac arrhythmias and sudden death: cantharidin-induced toxic cardiomyopathy. ( Ferris, JA; Friesen, JM; Fung, HY; Rabkin, SW, 1979) |
| "The anti-inflammatory activity of calcitonin gene-related peptide (CGRP) has been studied in cutaneous inflammation induced by croton oil (CO), arachidonic acid (AA), tetradecanoylphorbol acetate (TPA) or cantharidin (CA)." | 3.69 | Effects of CGRP in different models of mouse ear inflammation. ( Amico-Roxas, M; Caruso, A; Catena Cutuli, VM; Clementi, G; de Bernardis, E; Maugeri, S; Prato, A; Scapagnini, U, 1994) |
| "Cantharidin (CTD) is a promising anticancer drug; however, its dosage is limited by hepatotoxicity." | 1.62 | Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics. ( Chen, Y; Huang, X; Li, W; Lin, C; Liu, J; Sa, Z; Tang, W; Wang, L; Xu, M; Yang, C, 2021) |
| "To improve the treatment of lung cancer, there is necessity to identify novel oncogenes and investigate their effects on lung carcinogenesis." | 1.46 | Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. ( Chao, TI; Chen, KF; Chen, LJ; Chen, YL; Hsiao, YJ; Hsieh, FS; Hung, MH; Li, JR; Shih, CT; Tsai, MH; Wang, CY, 2017) |
| "The most common arrhythmias associated with the high doses of cantharidin were frequent ventricular ectopics, ventricular tachycardia, ventricular fibrillation or asytole." | 1.26 | A model of cardiac arrhythmias and sudden death: cantharidin-induced toxic cardiomyopathy. ( Ferris, JA; Friesen, JM; Fung, HY; Rabkin, SW, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, X | 1 |
| Tang, W | 1 |
| Lin, C | 1 |
| Sa, Z | 1 |
| Xu, M | 1 |
| Liu, J | 1 |
| Wang, L | 1 |
| Li, W | 1 |
| Chen, Y | 1 |
| Yang, C | 1 |
| Zhang, Y | 1 |
| Yang, SL | 1 |
| Zhang, HR | 1 |
| Gao, L | 1 |
| Gao, X | 1 |
| Liu, PJ | 1 |
| Yi, ZY | 1 |
| Li, N | 1 |
| Xu, ZQ | 1 |
| Hsieh, FS | 1 |
| Hung, MH | 1 |
| Wang, CY | 1 |
| Chen, YL | 1 |
| Hsiao, YJ | 1 |
| Tsai, MH | 1 |
| Li, JR | 1 |
| Chen, LJ | 1 |
| Shih, CT | 1 |
| Chao, TI | 1 |
| Chen, KF | 1 |
| Ivetic Tkalcevic, V | 1 |
| Hrvacic, B | 1 |
| Bosnar, M | 1 |
| Cuzic, S | 1 |
| Bosnjak, B | 1 |
| Erakovic Haber, V | 1 |
| Glojnaric, I | 1 |
| Gábor, M | 1 |
| Tarayre, JP | 1 |
| Aliaga, M | 1 |
| Barbara, M | 1 |
| Villanova, G | 1 |
| Caillol, V | 1 |
| Lauressergues, H | 1 |
| Clementi, G | 1 |
| Amico-Roxas, M | 1 |
| Caruso, A | 1 |
| Catena Cutuli, VM | 1 |
| Prato, A | 1 |
| Maugeri, S | 1 |
| de Bernardis, E | 1 |
| Scapagnini, U | 1 |
| Rabkin, SW | 1 |
| Friesen, JM | 1 |
| Ferris, JA | 1 |
| Fung, HY | 1 |
1 review available for cantharidin and Disease Models, Animal
| Article | Year |
|---|---|
Models of acute inflammation in the ear.
Topics: Alkynes; Animals; Anthralin; Arachidonic Acid; Cantharidin; Capsaicin; Carrageenan; Croton Oil; Derm | 2003 |
7 other studies available for cantharidin and Disease Models, Animal
| Article | Year |
|---|---|
Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics.
Topics: Animals; Antineoplastic Agents; Astragalus Plant; ATP-Binding Cassette Transporters; Cantharidin; Ch | 2021 |
Combination radiotherapy and cantharidin inhibits lung cancer growth through altering tumor infiltrating lymphocytes.
Topics: Animals; Cantharidin; Carcinoma, Lewis Lung; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; | 2017 |
Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Carcinoma, No | 2017 |
Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Azithromycin; Can | 2012 |
Pharmacological study of cantharidin-induced ear inflammation in mice.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Cantharidin; Disea | 1984 |
Effects of CGRP in different models of mouse ear inflammation.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Cantharidin; Capsa | 1994 |
A model of cardiac arrhythmias and sudden death: cantharidin-induced toxic cardiomyopathy.
Topics: Animals; Arrhythmias, Cardiac; Blood Chemical Analysis; Cantharidin; Cardiomyopathies; Death, Sudden | 1979 |