cantharidin has been researched along with Dermatoses in 20 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%." | 7.67 | Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product. ( Coskey, RJ, 1984) |
| "Cantharidin has been used to induce acantholysis in vivo." | 7.67 | Cantharidin-induced acantholysis. ( Piérard, GE; Piérard-Franchimont, C, 1988) |
| "One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%." | 3.67 | Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product. ( Coskey, RJ, 1984) |
| "Cantharidin has been used to induce acantholysis in vivo." | 3.67 | Cantharidin-induced acantholysis. ( Piérard, GE; Piérard-Franchimont, C, 1988) |
| " Using this assay we were able to demonstrate prostaglandin activity in dermal perfusates from 5 of 8 patients with contact dermatitis, and in blister fluid from 4 volunteers with contact dermatitis and 4 volunteers with cantharidin blisters." | 3.65 | Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay. ( Goldyne, ME; Ryan, RJ; Winkelmann, RK, 1973) |
| "The skin blister concentration/plasma concentration ratio reached values above 1." | 2.69 | Penetration of moxifloxacin into peripheral compartments in humans. ( Brunner, M; Eichler, HG; Lackner, E; Möller, JG; Müller, M; Stass, H, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (75.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aoun, O | 1 |
| François, M | 1 |
| Demoncheaux, JP | 1 |
| Rapp, C | 1 |
| Wong, J | 1 |
| Phelps, R | 1 |
| Levitt, J | 1 |
| WEBER, G | 1 |
| SKJAEGGESTAD, O | 1 |
| KAMINSKY, A | 1 |
| KAMINSKY, CA | 1 |
| BRAUNSTEIN, S | 1 |
| Lio, P | 1 |
| Coskey, RJ | 1 |
| Müller, M | 1 |
| Stass, H | 1 |
| Brunner, M | 1 |
| Möller, JG | 1 |
| Lackner, E | 1 |
| Eichler, HG | 1 |
| Moed, L | 1 |
| Shwayder, TA | 1 |
| Chang, MW | 1 |
| Brinchmann-Hansen, O | 1 |
| Piérard-Franchimont, C | 1 |
| Piérard, GE | 1 |
| Bertaux, B | 1 |
| Prost, C | 1 |
| Heslan, M | 1 |
| Dubertret, L | 1 |
| Juhlin, L | 1 |
| Baekken, T | 1 |
| Stüttgen, G | 1 |
| Neumann, D | 1 |
| Galletti, R | 1 |
| Matassi, L | 1 |
| Chiarini, P | 1 |
| De Biani, GF | 1 |
| Duranti, R | 1 |
| Laerum, OD | 1 |
| Iversen, OH | 1 |
| Goldyne, ME | 1 |
| Winkelmann, RK | 1 |
| Ryan, RJ | 1 |
| Sasai, Y | 1 |
| Komura, J | 1 |
| Wilkinson, RD | 1 |
| Bolton, PS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial Examining the Efficacy of Treatment of Cutaneous Verruca Vulgaris in Adult Patients With Combined Liquid Nitrogen Cryotherapy and Topically Applied Cantharidin[NCT01084824] | 70 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cantharidin and Dermatoses
| Article | Year |
|---|---|
Warts, molluscum and things that go bump on the skin: a practical guide.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Anti-Infective Agents; Cantharidin | 2007 |
Cantharidin revisited: a blistering defense of an ancient medicine.
Topics: Animals; Cantharidin; Coleoptera; Dermatology; Drug Approval; Humans; Irritants; Medicine, Tradition | 2001 |
1 trial available for cantharidin and Dermatoses
| Article | Year |
|---|---|
Penetration of moxifloxacin into peripheral compartments in humans.
Topics: 4-Quinolones; Adult; Anti-Infective Agents; Area Under Curve; Aza Compounds; Blister; Cantharidin; F | 1999 |
17 other studies available for cantharidin and Dermatoses
| Article | Year |
|---|---|
Morning blisters: cantharidin-related Meloidae burns.
Topics: Adult; Animals; Anti-Bacterial Agents; Blister; Cantharidin; Coleoptera; France; Humans; Male; Mali; | 2018 |
Treatment of acquired perforating dermatosis with cantharidin.
Topics: Aged; Anti-Allergic Agents; Cantharidin; Dermatologic Agents; Drug Therapy, Combination; Female; Hum | 2012 |
[Reaction of blood glutamic oxaloacetic acid transaminase & cantharides blister fluid in dermatoses].
Topics: Aspartate Aminotransferases; Blister; Body Fluids; Cantharidin; Humans; Inorganic Chemicals; Oxaloac | 1958 |
EXPERIMENTAL EPIDERMAL HYPERPLASIA IN MICE: RELATION TO CARCINOGENESIS.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cantharidin; Carcinogenesis; Carcinogens; Cell Division; | 1964 |
[Iatrogenic and accidental dermatosis caused by cantharidine].
Topics: Cantharidin; Dermatitis; Humans; Iatrogenic Disease; Skin Diseases | 1961 |
Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product.
Topics: Adolescent; Cantharidin; Child; Child, Preschool; Combined Modality Therapy; Debridement; Drug Thera | 1984 |
[Spanish fly. Case reports with discussion of its noxious effects on the skin and eye].
Topics: Adult; Cantharidin; Eye Diseases; Female; Humans; Middle Aged; Norway; Skin Diseases | 1978 |
Cantharidin-induced acantholysis.
Topics: Acantholysis; Administration, Topical; Biopsy; Cantharidin; DNA Replication; Humans; Skin; Skin Dise | 1988 |
Cantharide acantholysis: endogenous protease activation leading to desmosomal plaque dissolution.
Topics: Acantholysis; Cantharidin; Cells, Cultured; Desmosomes; Humans; Intermediate Filaments; Peptide Hydr | 1988 |
Histamine induced increase of basophil and eosinophil leukocytes in inflammatory exudates.
Topics: Basophils; Cantharidin; Eosinophils; Exudates and Transudates; Histamine; Humans; Inflammation; Leuk | 1965 |
[Isomorphic structure of cantharidin-blisters in various bullous dermatoses].
Topics: Acantholysis; Adult; Blister; Cantharidin; Dermatitis Herpetiformis; Drug Eruptions; Epidermolysis B | 1970 |
[Influence of indomethacin on the content of kininogen in the exudate from cutaneous inflammation induced by cantharidin in humans].
Topics: Cantharidin; Exudates and Transudates; Humans; Indomethacin; Inflammation; Kininogens; Skin Diseases | 1974 |
pH-dependence of epidermal respiration under normal conditions and in chemically induced hyperplasia. Comparison with the mitochondrial tetrazolium reduction.
Topics: Animals; Benzene; Cantharidin; Cell Movement; Female; Hydrogen-Ion Concentration; Hyperplasia; Lacta | 1973 |
Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay.
Topics: Animals; Antibody Formation; Blister; Cantharidin; Cross Reactions; Dermatitis, Contact; Female; Hum | 1973 |
An adaptation of the Lineweaver-Burk's graphical method to the histochemical system of phosphorylase in cantharidin acantholysis.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Biophysical Phenomena; Biophysics; Cantharidin; Edetic | 1965 |
An electron microscopic study of cantharidin-induced acantholysis.
Topics: Biopsy; Cantharidin; Humans; Microscopy, Electron; Ointments; Skin Diseases; Vitiligo | 1968 |
Clot formation in fluid from spontaneous and induced blisters.
Topics: Blister; Blood Coagulation; Blood Coagulation Factors; Burns; Cantharidin; Erythema Multiforme; Exud | 1966 |