Page last updated: 2024-11-08

cantharidin and Dermatoses

cantharidin has been researched along with Dermatoses in 20 studies

Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

Research Excerpts

ExcerptRelevanceReference
"One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%."7.67Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product. ( Coskey, RJ, 1984)
"Cantharidin has been used to induce acantholysis in vivo."7.67Cantharidin-induced acantholysis. ( Piérard, GE; Piérard-Franchimont, C, 1988)
"One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%."3.67Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product. ( Coskey, RJ, 1984)
"Cantharidin has been used to induce acantholysis in vivo."3.67Cantharidin-induced acantholysis. ( Piérard, GE; Piérard-Franchimont, C, 1988)
" Using this assay we were able to demonstrate prostaglandin activity in dermal perfusates from 5 of 8 patients with contact dermatitis, and in blister fluid from 4 volunteers with contact dermatitis and 4 volunteers with cantharidin blisters."3.65Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay. ( Goldyne, ME; Ryan, RJ; Winkelmann, RK, 1973)
"The skin blister concentration/plasma concentration ratio reached values above 1."2.69Penetration of moxifloxacin into peripheral compartments in humans. ( Brunner, M; Eichler, HG; Lackner, E; Möller, JG; Müller, M; Stass, H, 1999)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199015 (75.00)18.7374
1990's1 (5.00)18.2507
2000's2 (10.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aoun, O1
François, M1
Demoncheaux, JP1
Rapp, C1
Wong, J1
Phelps, R1
Levitt, J1
WEBER, G1
SKJAEGGESTAD, O1
KAMINSKY, A1
KAMINSKY, CA1
BRAUNSTEIN, S1
Lio, P1
Coskey, RJ1
Müller, M1
Stass, H1
Brunner, M1
Möller, JG1
Lackner, E1
Eichler, HG1
Moed, L1
Shwayder, TA1
Chang, MW1
Brinchmann-Hansen, O1
Piérard-Franchimont, C1
Piérard, GE1
Bertaux, B1
Prost, C1
Heslan, M1
Dubertret, L1
Juhlin, L1
Baekken, T1
Stüttgen, G1
Neumann, D1
Galletti, R1
Matassi, L1
Chiarini, P1
De Biani, GF1
Duranti, R1
Laerum, OD1
Iversen, OH1
Goldyne, ME1
Winkelmann, RK1
Ryan, RJ1
Sasai, Y1
Komura, J1
Wilkinson, RD1
Bolton, PS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Clinical Trial Examining the Efficacy of Treatment of Cutaneous Verruca Vulgaris in Adult Patients With Combined Liquid Nitrogen Cryotherapy and Topically Applied Cantharidin[NCT01084824]70 participants (Actual)Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for cantharidin and Dermatoses

ArticleYear
Warts, molluscum and things that go bump on the skin: a practical guide.
    Archives of disease in childhood. Education and practice edition, 2007, Volume: 92, Issue:4

    Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Anti-Infective Agents; Cantharidin

2007
Cantharidin revisited: a blistering defense of an ancient medicine.
    Archives of dermatology, 2001, Volume: 137, Issue:10

    Topics: Animals; Cantharidin; Coleoptera; Dermatology; Drug Approval; Humans; Irritants; Medicine, Tradition

2001

Trials

1 trial available for cantharidin and Dermatoses

ArticleYear
Penetration of moxifloxacin into peripheral compartments in humans.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:10

    Topics: 4-Quinolones; Adult; Anti-Infective Agents; Area Under Curve; Aza Compounds; Blister; Cantharidin; F

1999

Other Studies

17 other studies available for cantharidin and Dermatoses

ArticleYear
Morning blisters: cantharidin-related Meloidae burns.
    Journal of travel medicine, 2018, 07-01, Volume: 25, Issue:1

    Topics: Adult; Animals; Anti-Bacterial Agents; Blister; Cantharidin; Coleoptera; France; Humans; Male; Mali;

2018
Treatment of acquired perforating dermatosis with cantharidin.
    Archives of dermatology, 2012, Volume: 148, Issue:2

    Topics: Aged; Anti-Allergic Agents; Cantharidin; Dermatologic Agents; Drug Therapy, Combination; Female; Hum

2012
[Reaction of blood glutamic oxaloacetic acid transaminase & cantharides blister fluid in dermatoses].
    Dermatologische Wochenschrift, 1958, Mar-08, Volume: 137, Issue:10

    Topics: Aspartate Aminotransferases; Blister; Body Fluids; Cantharidin; Humans; Inorganic Chemicals; Oxaloac

1958
EXPERIMENTAL EPIDERMAL HYPERPLASIA IN MICE: RELATION TO CARCINOGENESIS.
    Acta pathologica et microbiologica Scandinavica. Supplementum, 1964

    Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cantharidin; Carcinogenesis; Carcinogens; Cell Division;

1964
[Iatrogenic and accidental dermatosis caused by cantharidine].
    La Semana medica, 1961, Nov-20, Volume: 119

    Topics: Cantharidin; Dermatitis; Humans; Iatrogenic Disease; Skin Diseases

1961
Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product.
    Pediatric dermatology, 1984, Volume: 2, Issue:1

    Topics: Adolescent; Cantharidin; Child; Child, Preschool; Combined Modality Therapy; Debridement; Drug Thera

1984
[Spanish fly. Case reports with discussion of its noxious effects on the skin and eye].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1978, Aug-30, Volume: 98, Issue:24

    Topics: Adult; Cantharidin; Eye Diseases; Female; Humans; Middle Aged; Norway; Skin Diseases

1978
Cantharidin-induced acantholysis.
    The American Journal of dermatopathology, 1988, Volume: 10, Issue:5

    Topics: Acantholysis; Administration, Topical; Biopsy; Cantharidin; DNA Replication; Humans; Skin; Skin Dise

1988
Cantharide acantholysis: endogenous protease activation leading to desmosomal plaque dissolution.
    The British journal of dermatology, 1988, Volume: 118, Issue:2

    Topics: Acantholysis; Cantharidin; Cells, Cultured; Desmosomes; Humans; Intermediate Filaments; Peptide Hydr

1988
Histamine induced increase of basophil and eosinophil leukocytes in inflammatory exudates.
    Acta dermato-venereologica, 1965, Volume: 45, Issue:5

    Topics: Basophils; Cantharidin; Eosinophils; Exudates and Transudates; Histamine; Humans; Inflammation; Leuk

1965
[Isomorphic structure of cantharidin-blisters in various bullous dermatoses].
    Archiv fur klinische und experimentelle Dermatologie, 1970, Volume: 238, Issue:1

    Topics: Acantholysis; Adult; Blister; Cantharidin; Dermatitis Herpetiformis; Drug Eruptions; Epidermolysis B

1970
[Influence of indomethacin on the content of kininogen in the exudate from cutaneous inflammation induced by cantharidin in humans].
    La Clinica terapeutica, 1974, Sep-30, Volume: 70, Issue:6

    Topics: Cantharidin; Exudates and Transudates; Humans; Indomethacin; Inflammation; Kininogens; Skin Diseases

1974
pH-dependence of epidermal respiration under normal conditions and in chemically induced hyperplasia. Comparison with the mitochondrial tetrazolium reduction.
    Archiv fur dermatologische Forschung, 1973, Jan-29, Volume: 246, Issue:1

    Topics: Animals; Benzene; Cantharidin; Cell Movement; Female; Hydrogen-Ion Concentration; Hyperplasia; Lacta

1973
Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay.
    Prostaglandins, 1973, Volume: 4, Issue:5

    Topics: Animals; Antibody Formation; Blister; Cantharidin; Cross Reactions; Dermatitis, Contact; Female; Hum

1973
An adaptation of the Lineweaver-Burk's graphical method to the histochemical system of phosphorylase in cantharidin acantholysis.
    The Tohoku journal of experimental medicine, 1965, Sep-25, Volume: 86, Issue:4

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Biophysical Phenomena; Biophysics; Cantharidin; Edetic

1965
An electron microscopic study of cantharidin-induced acantholysis.
    Acta dermatologica-Kyoto. English edition, 1968, Volume: 63, Issue:3

    Topics: Biopsy; Cantharidin; Humans; Microscopy, Electron; Ointments; Skin Diseases; Vitiligo

1968
Clot formation in fluid from spontaneous and induced blisters.
    The Journal of investigative dermatology, 1966, Volume: 46, Issue:1

    Topics: Blister; Blood Coagulation; Blood Coagulation Factors; Burns; Cantharidin; Erythema Multiforme; Exud

1966