cantharidin has been researched along with Dermatitis, Contact in 12 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A skin blister technique is described which allows the investigation of acute inflammation in humans in vivo." | 5.31 | Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans. ( Day, RM; Forbes, A; Harbord, M; Segal, AW, 2001) |
| "Thanks to local application of various compounds that inhibit the effects or the synthesis of histamine, serotonin, prostaglandins, thromboxanes and leukotrienes, hypotheses are proposed about the possible role of these mediators in various experimental inflammations induced on mouse ear: reactions to arachidonic acid, croton oil and cantharidin (6-h and 24-h phases); primary irritation and delayed hypersensitivity reaction to picryl chloride; and semi-delayed (6-h) and delayed (24-h) hypersensitivity to oxazolone." | 3.67 | Hypotheses on a possible role of some mediators in various inflammatory reactions on mouse ear. ( Aliaga, M; Barbara, M; Tarayre, JP; Tisné-Versailles, J, 1988) |
| " Using this assay we were able to demonstrate prostaglandin activity in dermal perfusates from 5 of 8 patients with contact dermatitis, and in blister fluid from 4 volunteers with contact dermatitis and 4 volunteers with cantharidin blisters." | 3.65 | Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay. ( Goldyne, ME; Ryan, RJ; Winkelmann, RK, 1973) |
| "A skin blister technique is described which allows the investigation of acute inflammation in humans in vivo." | 1.31 | Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans. ( Day, RM; Forbes, A; Harbord, M; Segal, AW, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wijerathne, BTB | 1 |
| Shah, A | 1 |
| Treat, J | 1 |
| Yan, AC | 1 |
| FREGERT, S | 1 |
| RORSMAN, H | 1 |
| Smith, JG | 1 |
| Burk, PG | 1 |
| Rosett, T | 1 |
| Church, CF | 1 |
| Swingle, KF | 1 |
| Reiter, MJ | 1 |
| Schwartzmiller, DH | 1 |
| Day, RM | 1 |
| Harbord, M | 1 |
| Forbes, A | 1 |
| Segal, AW | 1 |
| Klaschka, F | 1 |
| Galletti, R | 1 |
| Matassi, L | 1 |
| Chiarini, P | 1 |
| Corti, F | 1 |
| Nicholls, DS | 1 |
| Christmas, TI | 1 |
| Greig, DE | 1 |
| Tarayre, JP | 1 |
| Aliaga, M | 1 |
| Barbara, M | 1 |
| Tisné-Versailles, J | 1 |
| Burbach, JP | 1 |
| Goldyne, ME | 1 |
| Winkelmann, RK | 1 |
| Ryan, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Influence of Dietary Nitrate on Skin Inflammation in Healthy Volunteers[NCT03183830] | Phase 1 | 24 participants (Actual) | Interventional | 2017-02-02 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cantharidin and Dermatitis, Contact
| Article | Year |
|---|---|
Oedemerid blister beetle dermatosis: a review.
Topics: Animals; Cantharidin; Coleoptera; Dermatitis, Contact; Humans; New Zealand; Seasons; Skin Diseases, | 1990 |
11 other studies available for cantharidin and Dermatitis, Contact
| Article | Year |
|---|---|
Blister Mystery.
Topics: Animals; Blister; Cantharidin; Coleoptera; Dermatitis, Contact; Humans; Sri Lanka | 2017 |
Spread of cantharidin after petrolatum use resulting in a varicelliform vesicular dermatitis.
Topics: Cantharidin; Dermatitis, Contact; Enzyme Inhibitors; Female; Humans; Infant; Molluscum Contagiosum; | 2008 |
BASOPHIL LEUKOCYTES IN INTRACUTANEOUS TEST REACTIONS TO METALS.
Topics: Basophils; Cantharidin; Chromates; Cobalt; Dermatitis; Dermatitis, Contact; Exudates and Transudates | 1963 |
Enzymes in blister fluid.
Topics: Acid Phosphatase; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bl | 1967 |
Comparison of croton oil and cantharidin induced inflammations of the mouse ear and their modification by topically applied drugs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Cantharidin; Croton Oil; Dermatitis, Con | 1981 |
Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans.
Topics: Blister; Body Fluids; Cantharidin; Cell Movement; Cytokines; Dermatitis, Contact; Humans; Inflammati | 2001 |
[Nonallergic contact reactions of the skin].
Topics: Cantharidin; Dermatitis, Contact; Humans; Naphthalenes; Skin Tests; Terminology as Topic | 1977 |
Action of U.V. rays on the the experimental cutaneous inflammation induced by cantharidin.
Topics: Cantharidin; Dermatitis, Contact; Histamine; Humans; Inflammation; Pain; Radiation Effects; Time Fac | 1976 |
Hypotheses on a possible role of some mediators in various inflammatory reactions on mouse ear.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cantharidin; | 1988 |
The action of furan-maleic anhydride adduct and some of its derivatives.
Topics: Anhydrides; Animals; Cantharidin; Dermatitis, Contact; Drug Eruptions; Furans; Guinea Pigs; Humans; | 1967 |
Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay.
Topics: Animals; Antibody Formation; Blister; Cantharidin; Cross Reactions; Dermatitis, Contact; Female; Hum | 1973 |