cantharidin has been researched along with Colorectal Cancer in 9 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of transforming growth factor-beta (TGF-β) were investigated in human colorectal cancer, and the influence of cantharidinate in inhibiting TGF-β1 expression was explored." | 7.80 | Role of TGF-β1 in human colorectal cancer and effects after cantharidinate intervention. ( Gao, HC; Gao, HM; Hua, X; Lu, ZY; Ma, J, 2014) |
| "This systematic analysis was conducted to evaluate the efficacy and safety of cantharidin combined with chemotherapy in treating Chinese patients with metastatic colorectal cancer." | 7.80 | Cantharidin combined with chemotherapy for Chinese patients with metastatic colorectal cancer. ( Chen, X; Ding, H; Han, L; Pan, YF; Sun, YJ; Zhang, X, 2014) |
| " The aim of the current study was to understand the involvement of tTG in cancer and the inhibitory effect of cantharidinate on the expression of tTG in human colorectal cancer (CRC) using immunohistochemical and PCR analysis." | 7.79 | Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer. ( Gao, HC; Huang, W; Liang, CY; Liu, B; Liu, XM; Lu, TC; Yang, LL; Zhi, CY; Zhou, JH, 2013) |
| "Effects of Cantharidinate on apoptosis of human colorectal cancer UTC-116 cells were investigated by means of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, H and E staining, flow cytometry, and Raman Spectra analysis." | 7.78 | Apoptosis of colorectal cancer UTC116 cells induced by Cantharidinate. ( Cao, H; Fang, XD; Gao, HC; Gao, HM; Liu, B; Qiao, SX; Xu, JW, 2012) |
| "Effects of transforming growth factor-beta (TGF-β) were investigated in human colorectal cancer, and the influence of cantharidinate in inhibiting TGF-β1 expression was explored." | 3.80 | Role of TGF-β1 in human colorectal cancer and effects after cantharidinate intervention. ( Gao, HC; Gao, HM; Hua, X; Lu, ZY; Ma, J, 2014) |
| "This systematic analysis was conducted to evaluate the efficacy and safety of cantharidin combined with chemotherapy in treating Chinese patients with metastatic colorectal cancer." | 3.80 | Cantharidin combined with chemotherapy for Chinese patients with metastatic colorectal cancer. ( Chen, X; Ding, H; Han, L; Pan, YF; Sun, YJ; Zhang, X, 2014) |
| " The aim of the current study was to understand the involvement of tTG in cancer and the inhibitory effect of cantharidinate on the expression of tTG in human colorectal cancer (CRC) using immunohistochemical and PCR analysis." | 3.79 | Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer. ( Gao, HC; Huang, W; Liang, CY; Liu, B; Liu, XM; Lu, TC; Yang, LL; Zhi, CY; Zhou, JH, 2013) |
| "Effects of Cantharidinate on apoptosis of human colorectal cancer UTC-116 cells were investigated by means of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, H and E staining, flow cytometry, and Raman Spectra analysis." | 3.78 | Apoptosis of colorectal cancer UTC116 cells induced by Cantharidinate. ( Cao, H; Fang, XD; Gao, HC; Gao, HM; Liu, B; Qiao, SX; Xu, JW, 2012) |
| "Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide." | 1.91 | Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1. ( Herrmann, P; Ishfaq, MA; Schöpe, PC; Shoemaker, RH; Smith, J; Stein, U; Walther, W; Zinnow, V, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Schöpe, PC | 1 |
| Zinnow, V | 1 |
| Ishfaq, MA | 1 |
| Smith, J | 1 |
| Herrmann, P | 1 |
| Shoemaker, RH | 1 |
| Walther, W | 1 |
| Stein, U | 1 |
| Yang, LL | 1 |
| Liang, CY | 1 |
| Lu, TC | 1 |
| Zhi, CY | 1 |
| Liu, B | 2 |
| Zhou, JH | 1 |
| Liu, XM | 1 |
| Gao, HC | 3 |
| Huang, W | 1 |
| Ma, J | 1 |
| Gao, HM | 2 |
| Hua, X | 1 |
| Lu, ZY | 1 |
| Han, L | 1 |
| Sun, YJ | 1 |
| Pan, YF | 1 |
| Ding, H | 1 |
| Chen, X | 1 |
| Zhang, X | 1 |
| Huang, WW | 1 |
| Ko, SW | 1 |
| Tsai, HY | 1 |
| Chung, JG | 1 |
| Chiang, JH | 1 |
| Chen, KT | 1 |
| Chen, YC | 1 |
| Chen, HY | 1 |
| Chen, YF | 1 |
| Yang, JS | 1 |
| Xu, JW | 1 |
| Cao, H | 1 |
| Fang, XD | 1 |
| Qiao, SX | 1 |
| Sakoff, JA | 1 |
| Howitt, IJ | 1 |
| Ackland, SP | 1 |
| McCluskey, A | 1 |
| Yu, CW | 2 |
| Li, KK | 1 |
| Pang, SK | 2 |
| Au-Yeung, SC | 2 |
| Ho, YP | 2 |
9 other studies available for cantharidin and Colorectal Cancer
| Article | Year |
|---|---|
Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis-Inducing Genes S100A4 and MACC1.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cantharidin; Colorectal Neoplasms; Humans; Neoplasms; S100 | 2023 |
Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Cantharidin; Cell Line, Tumor; Cohort Studies; Colorectal Neoplasms; | 2013 |
Role of TGF-β1 in human colorectal cancer and effects after cantharidinate intervention.
Topics: Cantharidin; Cell Line, Tumor; Colorectal Neoplasms; Enzyme Inhibitors; HCT116 Cells; Humans; Mutati | 2014 |
Cantharidin combined with chemotherapy for Chinese patients with metastatic colorectal cancer.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cantharidin; China; Colorectal Neoplasms | 2014 |
Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways.
Topics: Apoptosis; Cantharidin; Caspases; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; Cell Survival; | 2011 |
Apoptosis of colorectal cancer UTC116 cells induced by Cantharidinate.
Topics: Apoptosis; Blotting, Western; Cantharidin; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Flo | 2012 |
Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.
Topics: Antimetabolites, Antineoplastic; Cantharidin; Carcinoma; Cell Cycle; Cell Division; Cell Line, Tumor | 2004 |
Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane.
Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Carboplatin; Carcinoma, Hepatocellular; Cell Cycle; C | 2006 |
DNA damage induced by novel demethylcantharidin-integrated platinum anticancer complexes.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cantharidin; Cell Line, Tumor | 2007 |