cantharidin has been researched along with Chromosomal Instability in 1 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Chromosomal Instability: An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we use synthetic dosage lethality (SDL), where the overexpression of PLK1 is lethal only when another, normally non-lethal, mutation or deletion is present." | 1.43 | Therapeutic relevance of the protein phosphatase 2A in cancer. ( Abuhussein, O; Alli, N; Anderson, DH; Bhanumathy, KK; Bonham, K; Boyd, F; Cunningham, CE; El Zawily, AM; Freywald, A; Furber, L; Geyer, R; Lee, JS; Li, S; McDonald, M; Mousseau, DD; Parameswaran, S; Paul, JM; Ruppin, E; Sablina, A; Shukla, H; Templeton, SD; Uppalapati, M; Vizeacoumar, FJ; Vizeacoumar, FS; Weaver, BA; Yan, J; Yu-Lee, LY, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cunningham, CE | 1 |
| Li, S | 1 |
| Vizeacoumar, FS | 1 |
| Bhanumathy, KK | 1 |
| Lee, JS | 1 |
| Parameswaran, S | 1 |
| Furber, L | 1 |
| Abuhussein, O | 1 |
| Paul, JM | 1 |
| McDonald, M | 1 |
| Templeton, SD | 1 |
| Shukla, H | 1 |
| El Zawily, AM | 1 |
| Boyd, F | 1 |
| Alli, N | 1 |
| Mousseau, DD | 1 |
| Geyer, R | 1 |
| Bonham, K | 1 |
| Anderson, DH | 1 |
| Yan, J | 1 |
| Yu-Lee, LY | 1 |
| Weaver, BA | 1 |
| Uppalapati, M | 1 |
| Ruppin, E | 1 |
| Sablina, A | 1 |
| Freywald, A | 1 |
| Vizeacoumar, FJ | 1 |
1 other study available for cantharidin and Chromosomal Instability
| Article | Year |
|---|---|
Therapeutic relevance of the protein phosphatase 2A in cancer.
Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Cell Cycle Proteins; Chromosomal Instability; Enzyme | 2016 |