cantharidin has been researched along with Cardiac Toxicity in 4 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the protective effect of L-glutamine, we used a high dose of cantharidin in mice to create a model of cardiotoxicity." | 7.96 | The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. ( Dong, L; Feng, Y; Shao, H; Tong, H; Wang, C, 2020) |
| "Cantharidin is a natural compound with cardiotoxicity." | 4.12 | Cantharidin induces senescence via inhibition of AMP-activated protein kinase and activation of NLRP3 inflammasome in H9c2 cardiomyocytes. ( Lv, Y; Qian, W; Shi, Y; You, Q, 2022) |
| "The cardiotoxicity of cantharidin has been well characterized, but the understanding of the underlying mechanism(s) is incomplete." | 3.96 | RNA-sequencing-based transcriptome analysis of cantharidin-induced myocardial injury. ( Liu, L; Ren, L; Zhang, Y, 2020) |
| "To investigate the protective effect of L-glutamine, we used a high dose of cantharidin in mice to create a model of cardiotoxicity." | 3.96 | The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. ( Dong, L; Feng, Y; Shao, H; Tong, H; Wang, C, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, Y | 1 |
| Lv, Y | 1 |
| You, Q | 1 |
| Qian, W | 1 |
| Youyou, Z | 1 |
| Yalei, Y | 1 |
| Jie, Z | 1 |
| Chuhuai, G | 1 |
| Liang, L | 1 |
| Liang, R | 1 |
| Zhang, Y | 1 |
| Liu, L | 1 |
| Ren, L | 1 |
| Shao, H | 1 |
| Dong, L | 1 |
| Feng, Y | 1 |
| Wang, C | 1 |
| Tong, H | 1 |
4 other studies available for cantharidin and Cardiac Toxicity
| Article | Year |
|---|---|
Cantharidin induces senescence via inhibition of AMP-activated protein kinase and activation of NLRP3 inflammasome in H9c2 cardiomyocytes.
Topics: AMP-Activated Protein Kinases; Cantharidin; Cardiotoxicity; Caspases; Humans; Inflammasomes; Myocyte | 2022 |
Molecular biomarkers of cantharidin-induced cardiotoxicity in Sprague-Dawley rats: Troponin T, vascular endothelial growth factor and hypoxia inducible factor-1α.
Topics: Animals; Biomarkers; Cantharidin; Cardiomyopathies; Cardiotoxicity; Dose-Response Relationship, Drug | 2020 |
RNA-sequencing-based transcriptome analysis of cantharidin-induced myocardial injury.
Topics: Animals; Cantharidin; Cardiotoxicity; Gene Expression Profiling; Gene Regulatory Networks; Heart Dis | 2020 |
The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice.
Topics: Animals; Antineoplastic Agents; Cantharidin; Cardiotonic Agents; Cardiotoxicity; Female; Glutamine; | 2020 |