cantharidin has been researched along with Carcinoma, Non-Small Cell Lung in 7 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To improve the treatment of lung cancer, there is necessity to identify novel oncogenes and investigate their effects on lung carcinogenesis." | 1.46 | Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. ( Chao, TI; Chen, KF; Chen, LJ; Chen, YL; Hsiao, YJ; Hsieh, FS; Hung, MH; Li, JR; Shih, CT; Tsai, MH; Wang, CY, 2017) |
| " Adverse effects on the gastrointestinal tract also were lower than in controls (p<0." | 1.40 | Safety of Brucea javanica and cantharidin combined with chemotherapy for treatment of NSCLC patients. ( Huang, XE; Ji, ZQ; Liu, J; Tang, JH; Wang, L; Wu, XY, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, K | 1 |
| Chen, R | 1 |
| Sun, Y | 1 |
| Tan, Z | 2 |
| Liu, Y | 1 |
| Cheng, X | 1 |
| Leng, J | 1 |
| Guo, Z | 1 |
| Xu, P | 1 |
| Li, X | 2 |
| Li, S | 1 |
| Pang, J | 1 |
| Huang, F | 1 |
| Guo, B | 1 |
| Liu, H | 2 |
| Hsieh, FS | 1 |
| Hung, MH | 1 |
| Wang, CY | 1 |
| Chen, YL | 1 |
| Hsiao, YJ | 1 |
| Tsai, MH | 1 |
| Li, JR | 1 |
| Chen, LJ | 1 |
| Shih, CT | 1 |
| Chao, TI | 1 |
| Chen, KF | 1 |
| Xiao, Z | 1 |
| Wang, C | 1 |
| Hu, S | 1 |
| Chen, Y | 1 |
| Zhou, M | 1 |
| Feng, J | 1 |
| Liu, S | 1 |
| Chen, L | 1 |
| Ding, J | 1 |
| Gong, Q | 1 |
| Tang, F | 1 |
| Wang, B | 1 |
| Cui, J | 1 |
| Ji, ZQ | 1 |
| Huang, XE | 1 |
| Wu, XY | 1 |
| Liu, J | 1 |
| Wang, L | 1 |
| Tang, JH | 1 |
| Hsia, TC | 1 |
| Yu, CC | 1 |
| Hsu, SC | 1 |
| Tang, NY | 1 |
| Lu, HF | 1 |
| Yu, CS | 1 |
| Wu, SH | 1 |
| Lin, JG | 1 |
| Chung, JG | 1 |
1 review available for cantharidin and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Clinical efficacy and safety of sodium cantharidinate plus chemotherapy in non-small-cell lung cancer: A systematic review and meta-analysis of 38 randomized controlled trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cantharidin; Carcinoma, Non-Small-Cell Lung; Humans; | 2019 |
1 trial available for cantharidin and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Treatment of mid-late stage NSCLC using sodium cantharidinate/vitamin B6/GP regimen in clinic.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cantharidin; Carcinoma, Non-Small-Cell Lung; China; | 2014 |
5 other studies available for cantharidin and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Cantharidin-loaded functional mesoporous titanium peroxide nanoparticles for non-small cell lung cancer targeted chemotherapy combined with high effective photodynamic therapy.
Topics: Cantharidin; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Humans; Lung Neoplasms; Nanoparticle | 2020 |
[Alkaline processing of cantharidin can significanty improve the antitumor activity of cantharidin].
Topics: Cantharidin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neop | 2020 |
Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Carcinoma, No | 2017 |
Safety of Brucea javanica and cantharidin combined with chemotherapy for treatment of NSCLC patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brucea; Cantharidin; | 2014 |
cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycl | 2015 |