cantharidin has been researched along with Cancer of Lung in 14 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To improve the treatment of lung cancer, there is necessity to identify novel oncogenes and investigate their effects on lung carcinogenesis." | 1.46 | Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. ( Chao, TI; Chen, KF; Chen, LJ; Chen, YL; Hsiao, YJ; Hsieh, FS; Hung, MH; Li, JR; Shih, CT; Tsai, MH; Wang, CY, 2017) |
| "Lung cancer is one of the leading causes of death in cancer-related diseases." | 1.40 | Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways. ( Chung, JG; Hsia, TC; Hsu, SC; Huang, YP; Lin, JG; Lu, HF; Tang, NY; Wu, SH; Yu, CC, 2014) |
| "Silver complexes have been shown to possess antimicrobial and anticancer properties." | 1.40 | Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial pathway. ( Jin, X; Li, S; Lou, J; Tan, X; Zhang, S; Zhang, X; Zhao, Y, 2014) |
| " Adverse effects on the gastrointestinal tract also were lower than in controls (p<0." | 1.40 | Safety of Brucea javanica and cantharidin combined with chemotherapy for treatment of NSCLC patients. ( Huang, XE; Ji, ZQ; Liu, J; Tang, JH; Wang, L; Wu, XY, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 10 (71.43) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Deng, S | 1 |
| Mao, Y | 1 |
| Li, H | 1 |
| Li, G | 1 |
| Zheng, K | 1 |
| Chen, R | 1 |
| Sun, Y | 1 |
| Tan, Z | 2 |
| Liu, Y | 2 |
| Cheng, X | 1 |
| Leng, J | 1 |
| Guo, Z | 1 |
| Xu, P | 1 |
| Li, X | 2 |
| Li, S | 2 |
| Pang, J | 1 |
| Huang, F | 1 |
| Guo, B | 1 |
| Liu, H | 2 |
| Zhang, Y | 1 |
| Yang, SL | 1 |
| Zhang, HR | 1 |
| Gao, L | 1 |
| Gao, X | 1 |
| Liu, PJ | 1 |
| Yi, ZY | 1 |
| Li, N | 1 |
| Xu, ZQ | 1 |
| Hsieh, FS | 1 |
| Hung, MH | 1 |
| Wang, CY | 1 |
| Chen, YL | 1 |
| Hsiao, YJ | 1 |
| Tsai, MH | 1 |
| Li, JR | 1 |
| Chen, LJ | 1 |
| Shih, CT | 1 |
| Chao, TI | 1 |
| Chen, KF | 1 |
| Sonoki, H | 1 |
| Tanimae, A | 1 |
| Furuta, T | 1 |
| Endo, S | 1 |
| Matsunaga, T | 1 |
| Ichihara, K | 1 |
| Ikari, A | 1 |
| Xiao, Z | 1 |
| Wang, C | 1 |
| Hu, S | 1 |
| Chen, Y | 1 |
| Zhou, M | 1 |
| Feng, J | 1 |
| Liu, S | 1 |
| Chen, L | 1 |
| Ding, J | 1 |
| Gong, Q | 1 |
| Tang, F | 1 |
| Kim, YM | 1 |
| Ku, MJ | 1 |
| Son, YJ | 1 |
| Yun, JM | 1 |
| Kim, SH | 1 |
| Lee, SY | 1 |
| Hsia, TC | 3 |
| Lin, JH | 1 |
| Hsu, SC | 2 |
| Tang, NY | 2 |
| Lu, HF | 3 |
| Wu, SH | 3 |
| Lin, JG | 3 |
| Chung, JG | 3 |
| Yu, CC | 2 |
| Huang, YP | 2 |
| Zhang, S | 1 |
| Jin, X | 1 |
| Tan, X | 1 |
| Lou, J | 1 |
| Zhang, X | 1 |
| Zhao, Y | 1 |
| Ji, ZQ | 1 |
| Huang, XE | 1 |
| Wu, XY | 1 |
| Liu, J | 1 |
| Wang, L | 1 |
| Tang, JH | 1 |
| Hsiao, YT | 1 |
| Bau, DT | 1 |
| Chang, SJ | 1 |
| Zhang, WD | 1 |
| Zhao, HR | 1 |
| Yan, Y | 1 |
| Wang, XH | 1 |
| Zong, ZH | 1 |
1 review available for cantharidin and Cancer of Lung
| Article | Year |
|---|---|
Clinical efficacy and safety of sodium cantharidinate plus chemotherapy in non-small-cell lung cancer: A systematic review and meta-analysis of 38 randomized controlled trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cantharidin; Carcinoma, Non-Small-Cell Lung; Humans; | 2019 |
13 other studies available for cantharidin and Cancer of Lung
| Article | Year |
|---|---|
Network Pharmacology Integrated Molecular Docking to Explore the Mechanism of Blister Beetle Therapy for Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; Animals; Cantharidin; Coleoptera; Lung Neoplasms; Molecular Docking Simulati | 2022 |
Cantharidin-loaded functional mesoporous titanium peroxide nanoparticles for non-small cell lung cancer targeted chemotherapy combined with high effective photodynamic therapy.
Topics: Cantharidin; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Humans; Lung Neoplasms; Nanoparticle | 2020 |
[Alkaline processing of cantharidin can significanty improve the antitumor activity of cantharidin].
Topics: Cantharidin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neop | 2020 |
Combination radiotherapy and cantharidin inhibits lung cancer growth through altering tumor infiltrating lymphocytes.
Topics: Animals; Cantharidin; Carcinoma, Lewis Lung; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; | 2017 |
Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cantharidin; Carcinoma, No | 2017 |
Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells.
Topics: A549 Cells; Adenocarcinoma of Lung; Caffeic Acids; Cantharidin; Cell Line, Tumor; Cell Proliferation | 2018 |
Anti-metastatic effect of cantharidin in A549 human lung cancer cells.
Topics: Antineoplastic Agents; Cantharidin; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Dru | 2013 |
Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.
Topics: Apoptosis; Cantharidin; Cell Line, Tumor; Comet Assay; DNA Damage; DNA Repair; DNA Repair Enzymes; H | 2015 |
Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways.
Topics: Apoptosis; Calcium; Cantharidin; Caspase 3; Caspase 8; Cell Cycle; Cell Line, Tumor; Endoplasmic Ret | 2014 |
Singly protonated dehydronorcantharidin silver coordination polymer induces apoptosis of lung cancer cells via reactive oxygen species-mediated mitochondrial pathway.
Topics: Antineoplastic Agents; Apoptosis; Cantharidin; Cell Line, Tumor; Dose-Response Relationship, Drug; D | 2014 |
Safety of Brucea javanica and cantharidin combined with chemotherapy for treatment of NSCLC patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brucea; Cantharidin; | 2014 |
Cantharidin Impairs Cell Migration and Invasion of Human Lung Cancer NCI-H460 Cells via UPA and MAPK Signaling Pathways.
Topics: Cantharidin; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Humans; Lung Neoplasms; MAP Kinase | 2016 |
[Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms].
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cantharidin; Cell Line | 2005 |