cantharidin has been researched along with Breast Neoplasms in 7 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess side effects on Cantharidin sodium and Shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively." | 7.80 | Clinical study on safety of cantharidin sodium and shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively. ( Cao, J; Huang, XE; Wang, L, 2014) |
| "In a xenograft model of breast cancer, cantharidin inhibited tumor growth in a dose-dependent manner." | 5.46 | Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway. ( Gu, JZ; Gu, XD; Xie, XH; Xu, LL; Zhao, H, 2017) |
| "To assess side effects on Cantharidin sodium and Shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively." | 3.80 | Clinical study on safety of cantharidin sodium and shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively. ( Cao, J; Huang, XE; Wang, L, 2014) |
| " Cantharidin and norcantharidin are potent protein phosphatase 2A (PP2A) inhibitors that exhibit in vitro and in vivo antitumor activity against several types of cancer, including breast cancer." | 3.79 | Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. ( Chen, K; Dai, KS; Gong, FR; Li, W; Li, ZY; Lian, L; Mao, YX; Shou, LM; Tao, M; Xie, X; Zhang, QY, 2013) |
| "Breast cancer is the leading cause of cancer-related death in women worldwide, and despite multiple chemotherapeutic approaches, effective treatment strategies for advanced metastatic breast cancer are still lacking." | 1.62 | Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis. ( Ge, XM; Huang, FH; Li, S; Li, X; Pang, JL; Wu, Y; Zhang, YH, 2021) |
| "In a xenograft model of breast cancer, cantharidin inhibited tumor growth in a dose-dependent manner." | 1.46 | Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway. ( Gu, JZ; Gu, XD; Xie, XH; Xu, LL; Zhao, H, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Pang, JL | 1 |
| Huang, FH | 1 |
| Zhang, YH | 1 |
| Wu, Y | 1 |
| Ge, XM | 1 |
| Li, S | 1 |
| Li, X | 1 |
| Lu, CW | 1 |
| Belashov, AV | 1 |
| Zhikhoreva, AA | 1 |
| Semenova, IV | 1 |
| Cheng, CJ | 1 |
| Su, LY | 1 |
| Wu, CH | 1 |
| Gu, XD | 1 |
| Xu, LL | 1 |
| Zhao, H | 1 |
| Gu, JZ | 1 |
| Xie, XH | 1 |
| Shou, LM | 1 |
| Zhang, QY | 1 |
| Li, W | 1 |
| Xie, X | 1 |
| Chen, K | 1 |
| Lian, L | 1 |
| Li, ZY | 1 |
| Gong, FR | 1 |
| Dai, KS | 1 |
| Mao, YX | 1 |
| Tao, M | 1 |
| Wang, L | 1 |
| Huang, XE | 1 |
| Cao, J | 1 |
| Williams, LA | 1 |
| Möller, W | 1 |
| Merisor, E | 1 |
| Kraus, W | 1 |
| Rösner, H | 1 |
| Lacour, F | 1 |
| Delage, G | 1 |
| Lacour, J | 1 |
7 other studies available for cantharidin and Breast Neoplasms
| Article | Year |
|---|---|
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cantharidin; Cell Cycle Checkpoints; En | 2021 |
Application of digital holographic tomography in antitumor effect of cantharides complex on 4T1 breast cancer cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ca | 2021 |
Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cantharidin; Cell Line, Tumor; Cell Movement; Cell | 2017 |
Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin.
Topics: Apoptosis; Blood Platelets; Blotting, Western; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocy | 2013 |
Clinical study on safety of cantharidin sodium and shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms | 2014 |
In vitro anti-proliferation/cytotoxic activity of cantharidin (Spanish Fly) and related derivatives.
Topics: Anhydrides; Breast Neoplasms; Cantharidin; Cell Transformation, Neoplastic; Enzyme Activation; Enzym | 2003 |
[Diminution of the percentage of mononucleated phagocytes in patients with breast cancer].
Topics: Adult; Aged; Blister; Breast Neoplasms; Cantharidin; Female; Humans; Middle Aged; Phagocytes; Phagoc | 1977 |