Page last updated: 2024-11-08

cantharidin and Breast Neoplasms

cantharidin has been researched along with Breast Neoplasms in 7 studies

Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
"To assess side effects on Cantharidin sodium and Shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively."7.80Clinical study on safety of cantharidin sodium and shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively. ( Cao, J; Huang, XE; Wang, L, 2014)
"In a xenograft model of breast cancer, cantharidin inhibited tumor growth in a dose-dependent manner."5.46Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway. ( Gu, JZ; Gu, XD; Xie, XH; Xu, LL; Zhao, H, 2017)
"To assess side effects on Cantharidin sodium and Shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively."3.80Clinical study on safety of cantharidin sodium and shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively. ( Cao, J; Huang, XE; Wang, L, 2014)
" Cantharidin and norcantharidin are potent protein phosphatase 2A (PP2A) inhibitors that exhibit in vitro and in vivo antitumor activity against several types of cancer, including breast cancer."3.79Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. ( Chen, K; Dai, KS; Gong, FR; Li, W; Li, ZY; Lian, L; Mao, YX; Shou, LM; Tao, M; Xie, X; Zhang, QY, 2013)
"Breast cancer is the leading cause of cancer-related death in women worldwide, and despite multiple chemotherapeutic approaches, effective treatment strategies for advanced metastatic breast cancer are still lacking."1.62Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis. ( Ge, XM; Huang, FH; Li, S; Li, X; Pang, JL; Wu, Y; Zhang, YH, 2021)
"In a xenograft model of breast cancer, cantharidin inhibited tumor growth in a dose-dependent manner."1.46Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway. ( Gu, JZ; Gu, XD; Xie, XH; Xu, LL; Zhao, H, 2017)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Pang, JL1
Huang, FH1
Zhang, YH1
Wu, Y1
Ge, XM1
Li, S1
Li, X1
Lu, CW1
Belashov, AV1
Zhikhoreva, AA1
Semenova, IV1
Cheng, CJ1
Su, LY1
Wu, CH1
Gu, XD1
Xu, LL1
Zhao, H1
Gu, JZ1
Xie, XH1
Shou, LM1
Zhang, QY1
Li, W1
Xie, X1
Chen, K1
Lian, L1
Li, ZY1
Gong, FR1
Dai, KS1
Mao, YX1
Tao, M1
Wang, L1
Huang, XE1
Cao, J1
Williams, LA1
Möller, W1
Merisor, E1
Kraus, W1
Rösner, H1
Lacour, F1
Delage, G1
Lacour, J1

Other Studies

7 other studies available for cantharidin and Breast Neoplasms

ArticleYear
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
    Toxicology and applied pharmacology, 2021, 11-01, Volume: 430

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cantharidin; Cell Cycle Checkpoints; En

2021
Application of digital holographic tomography in antitumor effect of cantharides complex on 4T1 breast cancer cells.
    Applied optics, 2021, Apr-20, Volume: 60, Issue:12

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ca

2021
Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017, Jul-03, Volume: 50, Issue:7

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cantharidin; Cell Line, Tumor; Cell Movement; Cell

2017
Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin.
    Oncology reports, 2013, Volume: 30, Issue:3

    Topics: Apoptosis; Blood Platelets; Blotting, Western; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocy

2013
Clinical study on safety of cantharidin sodium and shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:14

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms

2014
In vitro anti-proliferation/cytotoxic activity of cantharidin (Spanish Fly) and related derivatives.
    The West Indian medical journal, 2003, Volume: 52, Issue:1

    Topics: Anhydrides; Breast Neoplasms; Cantharidin; Cell Transformation, Neoplastic; Enzyme Activation; Enzym

2003
[Diminution of the percentage of mononucleated phagocytes in patients with breast cancer].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, Jun-20, Volume: 284, Issue:23

    Topics: Adult; Aged; Blister; Breast Neoplasms; Cantharidin; Female; Humans; Middle Aged; Phagocytes; Phagoc

1977