cantharidin has been researched along with Bleb in 102 studies
Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.
cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical cantharidin demonstrated clearance of warts, particularly in combination with podophyllotixin and salicylic acid, and modest benefit for pediatric molluscum contagiosum with good tolerability and safety." | 8.98 | Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. ( Chopra, R; Silverberg, JI; Silverberg, NB; Vakharia, PP, 2018) |
| "The cantharidin-induced skin blister is a simple model for investigating cell migration and inflammatory mediator production at a site of inflammation." | 8.02 | Cantharidin-Induced Skin Blister as an In Vivo Model of Inflammation. ( Dawson, J; Vogelsanger, M, 2021) |
| "Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients." | 7.68 | Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients. ( Arnaud, A; Bruguerolle, B; Philip-Joet, F; Reynaud, M, 1992) |
| "Seventy-six digital and periungual warts in 40 patients were treated topically with cantharidin, a potent blistering agent." | 7.64 | Cantharidin treatment of digital and periungual warts. ( EPSTEIN, JH; EPSTEIN, WL, 1960) |
| "A first blister was induced at baseline and collected, immediately before the start of treatment and a second blister was obtained 7 days after the start of treatment." | 6.76 | Validation of the cantharidin-induced skin blister as an in vivo model of inflammation. ( Corraza, F; Dinh, PH; Doyen, V; Kassengera, Z; Mestdagh, K; Michel, O, 2011) |
| "In the blister group, the pain score continuously improved from 7." | 6.74 | [Pain-relieving effect of cantharidin blister on lumbar spinal stenosis]. ( Dobos, GJ; Kremer, G; Lüdtke, R; Michalsen, A; Musial, F; Rampp, T, 2009) |
| "A skin blister technique is described which allows the investigation of acute inflammation in humans in vivo." | 5.31 | Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans. ( Day, RM; Forbes, A; Harbord, M; Segal, AW, 2001) |
| "In normlipidemia, the highest percentage of lipid fractions was diffused to blister fluid; the percentage was lower in type IV hyperlipidemia, the lowest being in type II hyperlipidemia." | 5.29 | [Diffusion of lipid fractions through the barrier of cantharidin blisters in hyperlipidemias under conditions of clofibrate and rutinosid interaction]. ( Szamer, B, 1993) |
| " Thus, the chosen dosage regimens considered apt for gonorrhea led to high initial as well as long-standing drug levels." | 5.27 | Plasma and skin blister fluid levels of cefotiam and cefmenoxime after single intramuscular application of 1 g in gonorrhea. ( Korting, HC, 1984) |
| "Topical cantharidin demonstrated clearance of warts, particularly in combination with podophyllotixin and salicylic acid, and modest benefit for pediatric molluscum contagiosum with good tolerability and safety." | 4.98 | Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. ( Chopra, R; Silverberg, JI; Silverberg, NB; Vakharia, PP, 2018) |
| "A PubMed search was conducted using the term "cantharidin" combined with "warts", "plantar warts", "verruca vulgaris", "periungal", "subungual", "topical treatment", "topical therapy for warts", molluscum contagiosum", "perforating collagenosis," and "acantholysis." | 4.90 | Cantharidin: a comprehensive review of the clinical literature. ( DeMoll, E; Levitt, J; Pan, M; Torbeck, R, 2014) |
| "The cantharidin-induced skin blister is a simple model for investigating cell migration and inflammatory mediator production at a site of inflammation." | 4.02 | Cantharidin-Induced Skin Blister as an In Vivo Model of Inflammation. ( Dawson, J; Vogelsanger, M, 2021) |
| "Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients." | 3.68 | Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients. ( Arnaud, A; Bruguerolle, B; Philip-Joet, F; Reynaud, M, 1992) |
| " Using this assay we were able to demonstrate prostaglandin activity in dermal perfusates from 5 of 8 patients with contact dermatitis, and in blister fluid from 4 volunteers with contact dermatitis and 4 volunteers with cantharidin blisters." | 3.65 | Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay. ( Goldyne, ME; Ryan, RJ; Winkelmann, RK, 1973) |
| "Seventy-six digital and periungual warts in 40 patients were treated topically with cantharidin, a potent blistering agent." | 3.64 | Cantharidin treatment of digital and periungual warts. ( EPSTEIN, JH; EPSTEIN, WL, 1960) |
| "At 24 hours, cantharidin formed blisters of similar volume in both sexes; however, at 72 hours, blisters had only resolved in females." | 2.84 | Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. ( Ahluwalia, A; Bansal, J; Colas, RA; D'Acquisto, F; Dalli, J; Gee, LC; Kapil, V; Khambata, RS; Khan, S; Marelli-Berg, F; Pitrola, K; Rathod, KS; Shaw, C; Siddique, U; Van Eijl, S; Velmurugan, S, 2017) |
| "A first blister was induced at baseline and collected, immediately before the start of treatment and a second blister was obtained 7 days after the start of treatment." | 2.76 | Validation of the cantharidin-induced skin blister as an in vivo model of inflammation. ( Corraza, F; Dinh, PH; Doyen, V; Kassengera, Z; Mestdagh, K; Michel, O, 2011) |
| "Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is cardioprotective at lower doses (aspirin(low), 75 mg)." | 2.74 | Effects of low-dose aspirin on acute inflammatory responses in humans. ( Bellingan, G; Colville-Nash, P; de Souza, P; Gilroy, DW; Hobbs, A; Morris, T; Newson, J; Stables, M; Warner, T, 2009) |
| "In the blister group, the pain score continuously improved from 7." | 2.74 | [Pain-relieving effect of cantharidin blister on lumbar spinal stenosis]. ( Dobos, GJ; Kremer, G; Lüdtke, R; Michalsen, A; Musial, F; Rampp, T, 2009) |
| "The mean (SD) peak concentration of dalbavancin in plasma and blister fluid was 285 (31." | 2.73 | Pharmacokinetics of dalbavancin in plasma and skin blister fluid. ( Buckwalter, M; Dowell, JA; Nicolau, DP; Seltzer, E; Sun, HK, 2007) |
| "The skin blister concentration/plasma concentration ratio reached values above 1." | 2.69 | Penetration of moxifloxacin into peripheral compartments in humans. ( Brunner, M; Eichler, HG; Lackner, E; Möller, JG; Müller, M; Stass, H, 1999) |
| "We analysed human cantharidin-induced blister samples and inflammatory responses in TRPV1 transgenic mice." | 1.72 | 20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin. ( Ahluwalia, A; Bubb, K; Chen, J; Colas, R; Dalli, J; Hamers, A; Khambata, RS; Kumar, NA; Masucci, M; Montalvo Moreira, SA; Primus, CP; Rathod, K; Whitear, C, 2022) |
| "A single 10mm mechanical-suction blister formed and aspirated at 4 hours." | 1.43 | A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation. ( Day, RM; George, MJ; Gilroy, DW; Maini, AA; Motwani, MP; O'Brien, AJ, 2016) |
| "There are high concent of DC in the blister, which is differential and induce the secretion of Th1, the activation of T cell." | 1.34 | [A technique for investigating the component of cantharidin blisters by flow cytometry]. ( Cheng, T; Liu, HP; Shi, L; Zhang, YJ; Zou, XJ; Zu, P, 2007) |
| "The pharmacokinetic disposition of meropenem, administered at 500 mg every 8 h, in plasma and cantharidin-induced blister fluid is described." | 1.32 | Pharmacokinetic profile of meropenem, administered at 500 milligrams every 8 hours, in plasma and cantharidin-induced skin blister fluid. ( Maglio, D; Nicolau, DP; Nightingale, CH; Teng, R; Thyrum, PT, 2003) |
| "While inflammatory blisters have long been utilized as a means of evaluating antimicrobial disposition to aid in the development of new treatments for skin and skin structure infections, sparse data are available regarding the healing of the blisters once the experiment has been completed." | 1.32 | Production and resolution of cantharidin-induced inflammatory blisters. ( Maglio, D; Nicolau, DP; Nightingale, CH, 2003) |
| "A skin blister technique is described which allows the investigation of acute inflammation in humans in vivo." | 1.31 | Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans. ( Day, RM; Forbes, A; Harbord, M; Segal, AW, 2001) |
| "Skin blister sampling and microdialysis closely mirrored corresponding serum concentrations and, thus, proved to be suitable techniques for the assessment of peripheral compartment pharmacokinetics." | 1.30 | Direct assessment of peripheral pharmacokinetics in humans: comparison between cantharides blister fluid sampling, in vivo microdialysis and saliva sampling. ( Brunner, M; Eichler, HG; Jäger, D; Müller, M; Piegler, E; Schmid, R; Schmiedberger, A, 1998) |
| "In eight healthy volunteers, skin blisters were provoked by plasters containing cantharidin." | 1.29 | Pharmacodynamic activity of a cephalosporin, Ro 40-6890, in human skin blister fluid: antibiotic activity in concert with host defense mechanisms. ( Hesse, WH; Hoogkamer, JF; Sansano, S; Zimmerli, W, 1993) |
| "In normlipidemia, the highest percentage of lipid fractions was diffused to blister fluid; the percentage was lower in type IV hyperlipidemia, the lowest being in type II hyperlipidemia." | 1.29 | [Diffusion of lipid fractions through the barrier of cantharidin blisters in hyperlipidemias under conditions of clofibrate and rutinosid interaction]. ( Szamer, B, 1993) |
| "isthmica Werner." | 1.28 | [Blister dermatitis caused by Epicauta flagellaria (Erichson) (Coleoptera: Meloidae) species]. ( Johnson, CM; Méndez, E; Sáenz, RE, 1989) |
| " The serum half-life of norfloxacin was found to be 3." | 1.27 | The pharmacokinetics and tissue penetration of norfloxacin. ( Adhami, ZN; Crump, B; Weston, D; Wise, R, 1984) |
| "Plasma and cantharides blister fluid (CBF) levels were measured for 11 to 24 hours." | 1.27 | Ketoconazole concentrations in human skin blister fluid and plasma. ( Dorn, M; Korting, HC; Mutschler, E; Schäfer-Korting, M, 1984) |
| " Thus, the chosen dosage regimens considered apt for gonorrhea led to high initial as well as long-standing drug levels." | 1.27 | Plasma and skin blister fluid levels of cefotiam and cefmenoxime after single intramuscular application of 1 g in gonorrhea. ( Korting, HC, 1984) |
| "Blister fluid was obtained from blisters 10-22 h old." | 1.26 | Does cantharides blister fluid provide access to the peripheral compartment? ( Hiemstra, S; Korting, HC; Mutschler, E; Schäfer-Korting, M, 1982) |
| "By means of blister formation produced by cantharidin, a certain number of human macrophages could be readily obtained from the blister exudate." | 1.26 | Investigation of the human macrophage. I. Collection and in vitro cultivation. ( Chang, YC; Yao, CS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (75.49) | 18.7374 |
| 1990's | 5 (4.90) | 18.2507 |
| 2000's | 10 (9.80) | 29.6817 |
| 2010's | 7 (6.86) | 24.3611 |
| 2020's | 3 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Hamers, A | 1 |
| Primus, CP | 1 |
| Whitear, C | 1 |
| Kumar, NA | 1 |
| Masucci, M | 1 |
| Montalvo Moreira, SA | 1 |
| Rathod, K | 1 |
| Chen, J | 1 |
| Bubb, K | 1 |
| Colas, R | 1 |
| Khambata, RS | 2 |
| Dalli, J | 2 |
| Ahluwalia, A | 2 |
| De Maeyer, RPH | 1 |
| van de Merwe, RC | 1 |
| Louie, R | 1 |
| Bracken, OV | 1 |
| Devine, OP | 1 |
| Goldstein, DR | 1 |
| Uddin, M | 1 |
| Akbar, AN | 1 |
| Gilroy, DW | 3 |
| Dawson, J | 1 |
| Vogelsanger, M | 1 |
| Wijerathne, BTB | 1 |
| Aoun, O | 1 |
| François, M | 1 |
| Demoncheaux, JP | 1 |
| Rapp, C | 1 |
| Vakharia, PP | 1 |
| Chopra, R | 1 |
| Silverberg, NB | 2 |
| Silverberg, JI | 1 |
| Torbeck, R | 1 |
| Pan, M | 1 |
| DeMoll, E | 1 |
| Levitt, J | 1 |
| Maini, AA | 1 |
| George, MJ | 1 |
| Motwani, MP | 1 |
| Day, RM | 2 |
| O'Brien, AJ | 1 |
| Rathod, KS | 1 |
| Kapil, V | 1 |
| Velmurugan, S | 1 |
| Siddique, U | 1 |
| Khan, S | 1 |
| Van Eijl, S | 1 |
| Gee, LC | 1 |
| Bansal, J | 1 |
| Pitrola, K | 1 |
| Shaw, C | 1 |
| D'Acquisto, F | 1 |
| Colas, RA | 1 |
| Marelli-Berg, F | 1 |
| Fortenbach, CR | 1 |
| Modjtahedi, BS | 1 |
| Maibach, HI | 1 |
| SAMTER, M | 1 |
| Morris, T | 1 |
| Stables, M | 1 |
| Hobbs, A | 1 |
| de Souza, P | 1 |
| Colville-Nash, P | 1 |
| Warner, T | 1 |
| Newson, J | 1 |
| Bellingan, G | 1 |
| Rampp, T | 1 |
| Michalsen, A | 1 |
| Lüdtke, R | 1 |
| Musial, F | 1 |
| Kremer, G | 1 |
| Dobos, GJ | 1 |
| Dinh, PH | 1 |
| Corraza, F | 1 |
| Mestdagh, K | 1 |
| Kassengera, Z | 1 |
| Doyen, V | 1 |
| Michel, O | 1 |
| Maglio, D | 2 |
| Teng, R | 1 |
| Thyrum, PT | 1 |
| Nightingale, CH | 2 |
| Nicolau, DP | 3 |
| WEICKSEL, P | 1 |
| DIMMLING, T | 1 |
| NEUMANN, H | 1 |
| HOMMER, E | 1 |
| ANTONINI, FM | 1 |
| PIVA, G | 1 |
| BARTELHEIMER, H | 2 |
| STEINORTH, G | 1 |
| OLK, W | 1 |
| ANSELL, BM | 1 |
| ANTONINI, F | 1 |
| GLYNN, LE | 1 |
| ADAM, W | 1 |
| KORTING, GW | 2 |
| NEXMAND, PH | 1 |
| SCHOOG-LUTZENKIRCHEN, A | 1 |
| PEZZOLO, A | 1 |
| CONTI, A | 1 |
| FERRANTE, G | 1 |
| WEBER, G | 1 |
| ALLISON, JH | 2 |
| BETTLEY, FR | 1 |
| WITTE, S | 2 |
| BRESSEL, D | 2 |
| RAJKA, G | 1 |
| WILLIAMSON, DH | 1 |
| WEAKLEY, DR | 2 |
| EINBINDER, JM | 2 |
| DEMETRIADES, T | 1 |
| SKLAVUNU-ZURUKZOGLU, S | 1 |
| EPSTEIN, JH | 1 |
| EPSTEIN, WL | 1 |
| FINDLAY, GH | 1 |
| BURBACH, JP | 1 |
| STACHOW, A | 1 |
| SMOKTUNOWICZ-MAZURKIEWICZ, W | 1 |
| CHORZELSKI, T | 2 |
| LANGNER, A | 2 |
| KLIGMAN, AM | 1 |
| CHRISTOPHERS, E | 1 |
| BOGGS, DR | 1 |
| ATHENS, JW | 1 |
| HAAB, OP | 1 |
| RAAB, SO | 1 |
| CARTWRIGHT, GE | 1 |
| WINTROBE, MM | 1 |
| GOMEZORBANEJA, J | 1 |
| ROBLEDOAGUILAR, A | 1 |
| JUHLIN, L | 2 |
| BERNASCONI, C | 1 |
| BEDARIDA, C | 1 |
| LAZZARINO, M | 1 |
| BREHM, G | 2 |
| MARTIN, G | 1 |
| CRONK, GA | 1 |
| DICKISON, HL | 1 |
| SCHLANGE, H | 1 |
| SCHWARTZKOPFF, W | 2 |
| KUTZIM, H | 1 |
| Yagnik, DR | 1 |
| Evans, BJ | 1 |
| Florey, O | 1 |
| Mason, JC | 1 |
| Landis, RC | 1 |
| Haskard, DO | 1 |
| Sun, HK | 1 |
| Seltzer, E | 1 |
| Buckwalter, M | 1 |
| Dowell, JA | 1 |
| Zou, XJ | 1 |
| Liu, HP | 1 |
| Cheng, T | 1 |
| Shi, L | 1 |
| Zu, P | 1 |
| Zhang, YJ | 1 |
| Smith, JG | 2 |
| Burk, PG | 1 |
| Rosett, T | 1 |
| Church, CF | 1 |
| Kandhari, KC | 1 |
| Bhide, NK | 1 |
| Sood, VK | 1 |
| Grosfeld, JC | 4 |
| Mighorst, JC | 4 |
| den Hartog, BC | 2 |
| van Ramshorst, AG | 2 |
| Schäfer-Korting, M | 4 |
| Korting, HC | 5 |
| Dorn, M | 1 |
| Mutschler, E | 3 |
| Adhami, ZN | 1 |
| Wise, R | 3 |
| Weston, D | 1 |
| Crump, B | 1 |
| Haag, R | 1 |
| Baker, S | 1 |
| Wright, N | 1 |
| Livingston, R | 1 |
| Stüttgen, G | 2 |
| Hiemstra, S | 1 |
| Hoogkamer, JF | 1 |
| Hesse, WH | 1 |
| Sansano, S | 1 |
| Zimmerli, W | 1 |
| Szamer, B | 1 |
| Brunner, M | 2 |
| Schmiedberger, A | 1 |
| Schmid, R | 1 |
| Jäger, D | 1 |
| Piegler, E | 1 |
| Eichler, HG | 2 |
| Müller, M | 2 |
| Stass, H | 1 |
| Möller, JG | 1 |
| Lackner, E | 1 |
| Sidbury, R | 1 |
| Mancini, AJ | 1 |
| Harbord, M | 1 |
| Forbes, A | 1 |
| Segal, AW | 1 |
| Lacour, F | 1 |
| Delage, G | 1 |
| Lacour, J | 1 |
| Chang, YC | 1 |
| Yao, CS | 1 |
| Philip-Joet, F | 1 |
| Bruguerolle, B | 1 |
| Reynaud, M | 1 |
| Arnaud, A | 1 |
| Méndez, E | 1 |
| Sáenz, RE | 1 |
| Johnson, CM | 1 |
| Schlaf-Maier, U | 1 |
| Burnett, JW | 1 |
| Calton, GJ | 1 |
| Morgan, RJ | 1 |
| Schmid, P | 1 |
| Consden, R | 1 |
| Smith, M | 1 |
| Kimura, I | 1 |
| Tanizaki, Y | 1 |
| Takahashi, K | 1 |
| Saito, K | 1 |
| Ueda, N | 1 |
| Hadlich, J | 2 |
| Neumann, D | 1 |
| Goldyne, ME | 1 |
| Winkelmann, RK | 1 |
| Ryan, RJ | 1 |
| Crounse, RG | 1 |
| Spence, D | 1 |
| Presto, AJ | 1 |
| Muecke, EC | 1 |
| Piper, HG | 1 |
| Würbach, G | 1 |
| Bologna, E | 4 |
| Salfeld, K | 1 |
| Hatano, H | 1 |
| Okido, M | 1 |
| Usui, K | 1 |
| Carlizza, L | 3 |
| Wilkinson, RD | 1 |
| Bolton, PS | 1 |
| Wadman, B | 1 |
| Decker, RH | 1 |
| Bagatell, FK | 1 |
| Dugan, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Influence of Dietary Nitrate on Skin Inflammation in Healthy Volunteers[NCT03183830] | Phase 1 | 24 participants (Actual) | Interventional | 2017-02-02 | Completed | ||
| Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women: RESOLVE-SEX[NCT05597098] | Early Phase 1 | 34 participants (Anticipated) | Interventional | 2022-12-12 | Active, not recruiting | ||
| A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Effect of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women[NCT04889274] | Phase 1 | 98 participants (Actual) | Interventional | 2021-05-10 | Active, not recruiting | ||
| Investigation of the Influence of Gender on Cardiovascular Function and Inflammation[NCT01582321] | Early Phase 1 | 56 participants (Anticipated) | Interventional | 2012-03-31 | Completed | ||
| The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268] | Phase 4 | 72 participants (Actual) | Interventional | 2019-04-24 | Completed | ||
| Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass[NCT00131040] | 24 participants | Interventional | 2003-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for cantharidin and Bleb
| Article | Year |
|---|---|
Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review.
Topics: Administration, Cutaneous; Blister; Cantharidin; Drug Therapy, Combination; Humans; Incidence; Irrit | 2018 |
Cantharidin: a comprehensive review of the clinical literature.
Topics: Administration, Topical; Blister; Cantharidin; Erythema; Humans; Molluscum Contagiosum; Pain; Warts | 2014 |
Role of physical chemical properties in drug relay into skin compartments.
Topics: Administration, Oral; Anti-Bacterial Agents; Area Under Curve; Blister; Cantharidin; Extracellular F | 2008 |
[The pathophysiology of blistering (author's transl)].
Topics: Blister; Cantharidin; Humans; Iodine; Skin Diseases, Vesiculobullous; Trypsin | 1980 |
7 trials available for cantharidin and Bleb
| Article | Year |
|---|---|
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Topics: Adolescent; Adult; Blister; Brachial Artery; Cantharidin; Female; Humans; Inflammation; Inflammation | 2017 |
Effects of low-dose aspirin on acute inflammatory responses in humans.
Topics: Acute Disease; Aspirin; Blister; Cantharidin; Cell Adhesion; Chemotaxis, Leukocyte; Dose-Response Re | 2009 |
[Pain-relieving effect of cantharidin blister on lumbar spinal stenosis].
Topics: Administration, Topical; Aged; Aged, 80 and over; Back Pain; Blister; Cantharidin; Complementary The | 2009 |
Validation of the cantharidin-induced skin blister as an in vivo model of inflammation.
Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Blister; Cantharidin | 2011 |
Pharmacokinetics of dalbavancin in plasma and skin blister fluid.
Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Biotransformation; Blister; Cantharidin; Chromatogra | 2007 |
Penetration of moxifloxacin into peripheral compartments in humans.
Topics: 4-Quinolones; Adult; Anti-Infective Agents; Area Under Curve; Aza Compounds; Blister; Cantharidin; F | 1999 |
Childhood molluscum contagiosum: experience with cantharidin therapy in 300 patients.
Topics: Blister; Cantharidin; Child; Child, Preschool; Erythema; Female; Humans; Irritants; Male; Molluscum | 2000 |
91 other studies available for cantharidin and Bleb
| Article | Year |
|---|---|
20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin.
Topics: Animals; Arachidonic Acid; Blister; Cantharidin; Edema; Humans; Hydroxyeicosatetraenoic Acids; Ligan | 2022 |
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly.
Topics: Age Factors; Aged; Animals; Apoptosis; Blister; Cantharidin; Gene Expression; Humans; Immunity, Inna | 2020 |
Cantharidin-Induced Skin Blister as an In Vivo Model of Inflammation.
Topics: Anti-Inflammatory Agents; Blister; Cantharidin; Humans; Inflammation; Skin | 2021 |
Blister Mystery.
Topics: Animals; Blister; Cantharidin; Coleoptera; Dermatitis, Contact; Humans; Sri Lanka | 2017 |
Morning blisters: cantharidin-related Meloidae burns.
Topics: Adult; Animals; Anti-Bacterial Agents; Blister; Cantharidin; Coleoptera; France; Humans; Male; Mali; | 2018 |
A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation.
Topics: Adolescent; Adult; Blister; Cantharidin; CD11b Antigen; Flow Cytometry; Humans; Inflammation; Interc | 2016 |
Cantharidin blister studies.
Topics: Blister; Cantharidin; Humans | 1948 |
Pharmacokinetic profile of meropenem, administered at 500 milligrams every 8 hours, in plasma and cantharidin-induced skin blister fluid.
Topics: Adult; Area Under Curve; Blister; Cantharidin; Drug Administration Schedule; Half-Life; Humans; Mero | 2003 |
Production and resolution of cantharidin-induced inflammatory blisters.
Topics: Anti-Bacterial Agents; Blister; Cantharidin; Humans; Inflammation; Irritants; Skin; Skin Pigmentatio | 2003 |
[Determination of penicillin in the puncture fluid of fresh vesicular inflammation caused by cantharides].
Topics: Blister; Cantharidin; Inflammation; Penicillins; Punctures | 1952 |
[A specific tissue reaction in sarcoidosis; morphological investigation of the content of the fluid of a cantharide blister].
Topics: Blister; Body Fluids; Cantharidin; Humans; Inorganic Chemicals; Sarcoidosis | 1952 |
[Electrophoretic study of blister fluid from cantharides].
Topics: Blister; Body Fluids; Cantharidin; Electrophoresis; Inorganic Chemicals | 1952 |
[Fractionated analysis of tissue juice. II. Volume, cell content and potassium level of the tissue juice, with reference to the effect of hyaluronidase].
Topics: Blister; Body Fluids; Cantharidin; Food; Humans; Hyaluronoglucosaminidase; Inorganic Chemicals; Pota | 1951 |
Cantharides blisters in children with rheumatic fever.
Topics: Blister; Cantharidin; Child; Humans; Rheumatic Fever | 1953 |
[Comparative studies on the free amino acids in cantharides blister and serum].
Topics: Amino Acids; Antifibrinolytic Agents; Blister; Blood; Body Fluids; Cantharidin; Humans; Inorganic Ch | 1953 |
Cytologic studies of allergic reactions by means of cantharides blisters.
Topics: Blister; Cantharidin; Eczema; Humans; Hypersensitivity | 1954 |
[Corticoid-induced eosinophilic fluctuation in blood and cantharide blister fluid].
Topics: Adrenal Cortex Hormones; Blister; Body Fluids; Cantharidin; Eosinophils; Humans; Inorganic Chemicals | 1957 |
[Effect of radar therapy on blisters caused by cantharidal agents].
Topics: Blister; Cantharidin; Humans; Radar; Radiation Effects | 1957 |
[Study of cantharides blister fluid in the analysis of the mechanism of action of trypsin in the treatment of chronic peripheral arterial diseases].
Topics: Blister; Cantharidin; Humans; Peripheral Arterial Disease; Peripheral Vascular Diseases; Proteins; T | 1957 |
[Reaction of blood glutamic oxaloacetic acid transaminase & cantharides blister fluid in dermatoses].
Topics: Aspartate Aminotransferases; Blister; Body Fluids; Cantharidin; Humans; Inorganic Chemicals; Oxaloac | 1958 |
Investigations into cantharidin blisters raised on apparently normal skin in normal and abnormal subjects.
Topics: Blister; Cantharidin; Eczema | 1958 |
[Coagulation factors in cantharides blister fluid].
Topics: Blister; Blood Coagulation; Blood Coagulation Factors; Body Fluids; Cantharidin; Humans; Inorganic C | 1958 |
The effect of hydrocortisone on blisters produced by threshold concentrations of cantharidin; studies on the guinea pig.
Topics: Blister; Cantharidin; Guinea Pigs; Hydrocortisone | 1958 |
The abnormal cantharidin blister in atopy: an explanation of its production.
Topics: Blister; Cantharidin; Eczema; Hypersensitivity, Immediate | 1960 |
Observations on the biochemical genesis of acantholysis.
Topics: Acantholysis; Blister; Cantharidin; Humans; Skin | 1961 |
[The cell picture of cantharides blisters in children and its significance].
Topics: Blister; Cantharidin; Humans | 1960 |
Cantharidin treatment of digital and periungual warts.
Topics: Blister; Cantharidin; Child; Humans; Nail Diseases; Pain; Papilloma; Warts | 1960 |
Wart relapses at the edges of therapeutic cantharidin blisters.
Topics: Blister; Cantharidin; Chronic Disease; Humans; Neoplasm Recurrence, Local; Papilloma; Warts | 1959 |
Experiments on blister formation. IV. The action of cantharidin.
Topics: Blister; Cantharidin | 1961 |
[Chemical studies on blister contents in bullous diseases and in cantharidin blisters].
Topics: Blister; Cantharidin; Dermatitis Herpetiformis; Dermatology; Humans; Pemphigus; Skin; Skin Diseases, | 1962 |
The mechanism of cantharidin acantholysis.
Topics: Acantholysis; Blister; Cantharidin; Humans; Liver; Skin; Spleen | 1962 |
[Effect of magnesium ions on acantholysis produced artificially in vitro with the aid of cantharidin].
Topics: Acantholysis; Blister; Cantharidin; In Vitro Techniques; Ions; Magnesium; Skin | 1962 |
[Effect of magnesium ions on acantholysis produced artificially in vitro with the aid of cantharidin].
Topics: Acantholysis; Blister; Cantharidin; In Vitro Techniques; Ions; Magnesium; Skin | 1962 |
PREPARATION OF ISOLATED SHEETS OF HUMAN STRATUM CORNEUM.
Topics: Anatomy; Biomedical Technology; Blister; Cantharidin; Epidermis; Epithelium; Humans; Medical Laborat | 1963 |
INDUCED INFLAMMATORY EXUDATES IN NORMAL MAN. A METHOD DESIGNED TO STUDY THE QUALITATIVE AND QUANTITATIVE CELLULAR RESPONSE TO A PYOGENIC STIMULUS.
Topics: Blister; Cantharidin; Eosinophils; Exudates and Transudates; Humans; Inflammation; Injections; Leuko | 1964 |
[EXPERIMENTAL METHODS FOR THE PRODUCTION OF BLISTERS AND DIFFERENT MORPHOLOGICAL ASPECTS OF THE RESULTS].
Topics: Biopsy; Blister; Cantharidin; Dermatology; Pathology; Research; Research Design; Toxicology | 1963 |
BASOPHIL LEUKOCYTES IN ACNE.
Topics: Acne Vulgaris; Basophils; Blister; Cantharidin; Exudates and Transudates; Humans | 1965 |
[RESEARCH ON BLISTER FLUID FROM A CANTHARID PLASTER. II. ELECTROPHORETIC AND ULTRACENTRIFUGAL STUDY OF PROTEINS OF THE BLISTER SERUM].
Topics: Blister; Body Fluids; Cantharidin; Electrophoresis; Humans; Proteins; Ultracentrifugation | 1964 |
[ON THE PERMEATION OF BLOOD PROTEINS IN THE SKIN AND THEIR QUANITATIVE DETERMINATION IN A CANTHARIDES BLISTER MODEL].
Topics: Blister; Blood Proteins; Cantharidin; Chemistry Techniques, Analytical; Exudates and Transudates; Hu | 1964 |
[LOCAL ANTIBIOTIC FURUNCLE TREATMENT FACILITATED BY CANTHARIDAL BLISTERS].
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Blister; Cantharidin; Dermatologic Agen | 1964 |
Diffusion of tetracycline into tissue fluids: observations and inferences from cantharides-produced inflammatory fluids.
Topics: Anti-Bacterial Agents; Blister; Blood; Body Fluids; Cantharidin; Exudates and Transudates; Humans; P | 1955 |
[Studies on pyroracemic acid content of cantharides blister fluid].
Topics: Blister; Body Fluids; Cantharidin; Humans; Inorganic Chemicals; Pyruvates | 1955 |
[Transfer of tuberculin skin sensitivity from children to guinea pigs by means of cantharides blister sediment].
Topics: Animals; Blister; Cantharidin; Child; Guinea Pigs; Humans; Skin Physiological Phenomena; Tuberculin; | 1955 |
[Premeability studies on the cantharide blister basal surface].
Topics: Blister; Cantharidin; Capillary Permeability; Humans | 1959 |
[Electrophoretic examination of cantharide blister fluid and blood serum].
Topics: Blister; Body Fluids; Cantharidin; Electrophoresis; Humans; Inorganic Chemicals; Serum | 1951 |
Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation.
Topics: Anti-Inflammatory Agents; Blister; Cantharidin; Cells, Cultured; Crystallization; E-Selectin; Endoth | 2004 |
[A technique for investigating the component of cantharidin blisters by flow cytometry].
Topics: Adult; Animals; Antigens, CD; Blister; Body Fluids; Cantharidin; Coleoptera; Dendritic Cells; Flow C | 2007 |
Enzymes in blister fluid.
Topics: Acid Phosphatase; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bl | 1967 |
Role of some biologically active substances in the mechanism of blister formation.
Topics: Acetylcholine; Blister; Burns; Cantharidin; Epidermolysis Bullosa; Erythema Multiforme; Herpes Zoste | 1967 |
[Studies of the LDH level and the LDH isoenzyme pattern in cantharidine blister exudate of normal skin and in psoriasis].
Topics: Blister; Cantharidin; Exudates and Transudates; Humans; Isoenzymes; L-Lactate Dehydrogenase; Psorias | 1967 |
LDH isoenzymes in cantharidine blisters of the normal skin and psoriasis.
Topics: Blister; Cantharidin; Humans; Isoenzymes; L-Lactate Dehydrogenase; Psoriasis | 1967 |
Ketoconazole concentrations in human skin blister fluid and plasma.
Topics: Adult; Blister; Body Fluids; Cantharidin; Female; Half-Life; Humans; Ketoconazole; Male; Suction | 1984 |
Plasma and skin blister fluid levels of cefotiam and cefmenoxime after single intramuscular application of 1 g in gonorrhea.
Topics: Adult; Blister; Cantharidin; Cefmenoxime; Cefotaxime; Cefotiam; Female; Gonorrhea; Humans; Injection | 1984 |
The pharmacokinetics and tissue penetration of norfloxacin.
Topics: Adult; Anti-Infective Agents; Blister; Cantharidin; Exudates and Transudates; Half-Life; Humans; Kin | 1984 |
Plasma, cantharides blister fluid, and suction blister fluid levels of ceftizoxime after single intramuscular application for gonorrhea.
Topics: Adult; Blister; Cantharidin; Cefotaxime; Ceftizoxime; Dose-Response Relationship, Drug; Female; Gono | 1984 |
The pharmacokinetics of LY127935, a broad spectrum oxa-beta-lactam.
Topics: Adult; Blister; Cantharidin; Cephalosporins; Cephamycins; Exudates and Transudates; Half-Life; Human | 1980 |
Protein binding of beta-lactams: the effects on activity and pharmacology particularly tissue penetration. II. Studies in man.
Topics: Anti-Bacterial Agents; beta-Lactams; Blister; Body Fluids; Cantharidin; Humans; Protein Binding; Tis | 1983 |
Does cantharides blister fluid provide access to the peripheral compartment?
Topics: Adult; Bendroflumethiazide; Blister; Cantharidin; Cell Compartmentation; Female; Humans; Kinetics; M | 1982 |
Pharmacodynamic activity of a cephalosporin, Ro 40-6890, in human skin blister fluid: antibiotic activity in concert with host defense mechanisms.
Topics: Adult; Blister; Cantharidin; Cephalosporins; Exudates and Transudates; Humans; Male; Microbial Sensi | 1993 |
[Diffusion of lipid fractions through the barrier of cantharidin blisters in hyperlipidemias under conditions of clofibrate and rutinosid interaction].
Topics: Administration, Cutaneous; Adult; Blister; Cantharidin; Diffusion; Drug Interactions; Female; Humans | 1993 |
Direct assessment of peripheral pharmacokinetics in humans: comparison between cantharides blister fluid sampling, in vivo microdialysis and saliva sampling.
Topics: Acetaminophen; Adult; Area Under Curve; Blister; Cantharidin; Dialysis Solutions; Evaluation Studies | 1998 |
Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans.
Topics: Blister; Body Fluids; Cantharidin; Cell Movement; Cytokines; Dermatitis, Contact; Humans; Inflammati | 2001 |
[Diminution of the percentage of mononucleated phagocytes in patients with breast cancer].
Topics: Adult; Aged; Blister; Breast Neoplasms; Cantharidin; Female; Humans; Middle Aged; Phagocytes; Phagoc | 1977 |
Investigation of the human macrophage. I. Collection and in vitro cultivation.
Topics: Animals; Blister; Cantharidin; Cell Count; Cell Division; Cell Separation; Cells, Cultured; Chickens | 1979 |
Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients.
Topics: Asthma; Blister; Body Fluids; Cantharidin; Dose-Response Relationship, Drug; Erythrocytes; Humans; I | 1992 |
[Blister dermatitis caused by Epicauta flagellaria (Erichson) (Coleoptera: Meloidae) species].
Topics: Animals; Blister; Cantharidin; Child, Preschool; Coleoptera; Female; Humans; Hypersensitivity; Panam | 1989 |
[Antimicrobial effects of in vitro-simulated ketoconazole-cantharidin blister fluid levels on candida albicans].
Topics: Blister; Candida albicans; Cantharidin; Culture Media; Humans; Ketoconazole; Microbial Sensitivity T | 1986 |
Blister beetles: "Spanish fly".
Topics: Animals; Blister; Cantharidin; Coleoptera; Humans; United States | 1987 |
Quantitation of specific proteins in blister fluid.
Topics: Basement Membrane; Blister; Cantharidin; Capillaries; Cell Membrane Permeability; Epithelium; Exudat | 1970 |
Protein concentration of cantharides blisters in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Blister; Blood Proteins; Cantharidin; Capillary Permeability; Electrop | 1966 |
Emergence of basophils at sites of local allergic reactions using a skin vesicle test.
Topics: Allergens; Asthma; Basophils; Blister; Blood Cell Count; Cantharidin; Dermatitis, Atopic; Eosinophil | 1974 |
[Fibrinolytic activity in cantharide blisters of urticaria patients].
Topics: Blister; Cantharidin; Chronic Disease; Female; Fibrin; Fibrinogen; Fibrinolysin; Fibrinolysis; Human | 1968 |
[Isomorphic structure of cantharidin-blisters in various bullous dermatoses].
Topics: Acantholysis; Adult; Blister; Cantharidin; Dermatitis Herpetiformis; Drug Eruptions; Epidermolysis B | 1970 |
Prostaglandin activity in human cutaneous inflammation: detection by radioimmunoassay.
Topics: Animals; Antibody Formation; Blister; Cantharidin; Cross Reactions; Dermatitis, Contact; Female; Hum | 1973 |
Studies on the distribution and excretion of Haemaccel in man.
Topics: Ascitic Fluid; Blister; Cantharidin; Capillary Permeability; Carbon Isotopes; Cyanates; Gelatin; Hum | 1969 |
The effects of capsaicin on human skin, liver and epidermal lysosomes.
Topics: Acid Phosphatase; Amides; Aminohydrolases; Animals; Blister; Cantharidin; Condiments; Erythema; Gluc | 1970 |
A dose of Spanish fly.
Topics: Adult; Blister; Cantharidin; Diarrhea; Hematuria; Humans; Infusions, Parenteral; Male; Poisoning; Su | 1970 |
[Fibrinolytic activity of the skin in psoriasis and various other dermatoses].
Topics: Alopecia Areata; Antifibrinolytic Agents; Benzoates; Blister; Cantharidin; Fibrinolysis; Humans; Mal | 1967 |
LDH isoenzymes in cantharidine blisters of the normal skin and psoriasis.
Topics: Blister; Cantharidin; Humans; Isoenzymes; L-Lactate Dehydrogenase; Psoriasis; Skin | 1968 |
[Alkaline phosphatase and glycogen in the leukocytes found in the fluid blisters due to cantharides plaster].
Topics: Alkaline Phosphatase; Blister; Cantharidin; Glycogen; Humans; Leukocytes | 1968 |
A study of the LDH level and the LDH isoenzyme pattern in cantharidin blister fluid in normal skin and in psoriasis.
Topics: Blister; Cantharidin; Histocytochemistry; Humans; Isoenzymes; L-Lactate Dehydrogenase; Psoriasis; Sk | 1968 |
[On the problem of energy producing metabolism and amino acid metabolism in older human epidermis. 3. Enzyme studies of the blister substance in cantharidin blisters].
Topics: Adult; Aged; Aging; Amino Acids; Blister; Cantharidin; Exudates and Transudates; Glucosephosphate De | 1969 |
[Study on the level of kinin in the experimental blister fluid].
Topics: Blister; Bradykinin; Cantharidin; Humans; Inflammation; Kinins; Time Factors | 1969 |
[Morphological and cytometric study of blister fluid in experimental conditions: action of barbiturates].
Topics: Barbiturates; Blister; Cantharidin; Humans; Inflammation | 1965 |
[Changes in cutaneous reactivity in relation to age. Study of cantharide blister fluid in young and old adults].
Topics: Adult; Aged; Aging; Blister; Cantharidin; Female; Humans; Immunity; Male; Middle Aged | 1965 |
Clot formation in fluid from spontaneous and induced blisters.
Topics: Blister; Blood Coagulation; Blood Coagulation Factors; Burns; Cantharidin; Erythema Multiforme; Exud | 1966 |
Basophil leukocytes in cantharidin blisters on patients with internal disorders.
Topics: Adolescent; Adult; Aged; Alcoholism; Arthritis, Rheumatoid; Basophils; Blister; Cantharidin; Colitis | 1966 |
Cantharidin-induced acantholysis. Dependence on epidermal respiration.
Topics: Animals; Blister; Cantharidin; Glycolysis; In Vitro Techniques; Mice; Oxygen; Skin | 1966 |
[Variations of leukocytic sudanophilia in the course of experimental phlogosis].
Topics: Blister; Cantharidin; Exudates and Transudates; Female; Humans; Lipid Metabolism; Male; Neutrophils | 1966 |
Phospholipids and cantharidin induced acantholysis in human epidermis.
Topics: Blister; Cantharidin; Humans; Phospholipids; Skin | 1966 |
[On the extravascular behavior of coagulation factors in hemophilia A, thrombocytopenia and conditions with increased vascular permeability].
Topics: Blister; Blood Coagulation; Blood Coagulation Factors; Cantharidin; Capillary Permeability; Factor V | 1966 |